Brain Imaging and Behavior最新文献

{"title":"Universal or contextual? Rethinking brain structure-function links in autism through cross-cultural lenses.","authors":"Riza Amalia, Henny Indreswari, Ajeng Ayu Widiastuti","doi":"10.1007/s11682-025-01042-5","DOIUrl":"https://doi.org/10.1007/s11682-025-01042-5","url":null,"abstract":"","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling anomalies in visual processing regions in obsessive-compulsive disorder: evidence from gray matter volume and functional connectivity analyses.","authors":"Rui Liu, Fengxia Zhang, Pengchong Wang, Jia Luo, Yue Liu, Kaiyin Huang, Xiangyun Yang, Aihong Yu, Zhanjiang Li","doi":"10.1007/s11682-025-01039-0","DOIUrl":"https://doi.org/10.1007/s11682-025-01039-0","url":null,"abstract":"<p><p>Obsessive-compulsive disorder (OCD) is a prevalent neurological condition characterized by recurring obsessive thoughts and compulsive behaviors. The underlying mechanisms of the disorder remain poorly understood due to its considerable heterogeneity. Given the extensive brain impairments observed in OCD, this study aimed to investigate gray matter volume and functional connectivity in individuals with OCD using a multimodal neuroimaging approach, while also exploring the relationship between these neural changes and clinical symptom severity. Structural and resting-state functional magnetic resonance imaging data were collected from 56 OCD patients and 41 healthy controls. Voxel-based morphometry analysis was employed to identify gray matter volume differences between the patient and control groups. Compared to healthy controls, patients exhibited reduced gray matter volume in visual processing regions, including the cuneus, left calcarine, and middle occipital gyrus. Furthermore, whole-brain functional connectivity analysis was conducted on these regions with abnormal gray matter volume, showing increased connectivity between the visual processing areas and subcortical and prefrontal regions. Additionally, gray matter volume reductions in the left calcarine and middle temporal gyrus were significantly correlated with higher scores on the Yale-Brown Obsessive Compulsive Scale, suggesting a link between visual processing abnormalities and the severity of clinical symptoms. These findings highlight structural and functional alterations in visual-related brain regions as key contributors to the pathophysiology of OCD, providing valuable insights into its neural basis and potential avenues for therapeutic intervention.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural and pragmatic language skills in school-age children relate to resting state functional connectivity.","authors":"Julia C Hoyda, Hannah J Stewart, Jennifer Vannest, Karla N Washington, David R Moore","doi":"10.1007/s11682-025-01040-7","DOIUrl":"https://doi.org/10.1007/s11682-025-01040-7","url":null,"abstract":"<p><p>Language difficulties are common in school-age children but their etiology is often unknown. Although neural underpinnings of language have been well-studied in neurotypical individuals, functional connectivity differences between children with language difficulties and their typically-developing peers have not. There is little evidence regarding patterns of neural connectivity for children with language difficulties. Differences in neural networks related to degree of language difficulties and subtype of language skills (structural or pragmatic) are unclear. We examined expressive and receptive language networks, and an executive function network, in school-age children (8-12 years, n = 81) relative to their caregiver-reported language skills. We hypothesized that children with poorer structural and pragmatic language skills would have decreased connectivity in these networks. Participants were separated into groups by structural and pragmatic language scores: those with structural language difficulties (SLD), pragmatic language difficulties (PLD), and combined language difficulties (CLD, consisting of some participants in both SLD and PLD). The remainder of participants were in the typical language (TL) group. Results showed trends toward increased cross-hemispheric connectivity in age-matched controls relative to those with poorer language skills. Specifically, connectivity between bilateral inferior frontal gyri and areas including bilateral supplementary motor areas, cerebellar regions, and bilateral frontal gyri was associated with higher structural and pragmatic language scores. Connectivity among additional regions including bilateral superior temporal gyri and Heschl's gyrus showed both positive and negative correlation with both language scores. This suggests that reduced connectivity between regions involved in language processing may contribute to language difficulties in school-age children.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional connectivity of sensory and executive function networks during a story listening task is related to parent/child interaction during joint reading: a functional MRI diffusion map study.","authors":"Tzipi Horowitz Kraus, Marwan Bebar, Adi Jacobson, John Hutton","doi":"10.1007/s11682-025-01037-2","DOIUrl":"https://doi.org/10.1007/s11682-025-01037-2","url":null,"abstract":"<p><p>The quality of parent-child interaction during shared reading (\"shared reading quality\") is strongly linked to cognitive and relational benefits. However, the relationship between shared reading quality and activation and synchronization of reading-related brain networks has not yet been characterized. The current study involved 22 4-year-old girls who completed functional MRI including a validated stories listening task, and a primary parent. Prior to MRI, video observation of the parent and child reading together was conducted and later coded using a standardized scoring form quantifying parent-child verbal and nonverbal interaction. Behavioral measures included demographics and a maternal depression scale. To achieve this goal, fMRI stories-listening data was utilized to create a diffusion maps algorithm and then to classify the level of parent-child interaction during the shared reading observation. The algorithm clustered children with higher parent-child engagement scores with fMRI diffusion patterns in regions of the brain known to support reading. This study establishes proof-of-concept that applying this diffusion maps algorithm to brain functional connectivity data can reliably predict parent-child interaction during shared book reading. It also suggests that an algorithmic approach may be a novel, data-driven means to quantify parent-child interaction in different contexts (e.g., reading, play) and populations.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between social network size and brain structure in older adults living with HIV.","authors":"Vinaya Hari, Nancy E Mayo, Marie-Josee Brouillette, MaryAnn Noonan, Lesley K Fellows","doi":"10.1007/s11682-025-00995-x","DOIUrl":"10.1007/s11682-025-00995-x","url":null,"abstract":"<p><p>The social brain hypothesis suggests that primate brains evolved to manage social group complexities. While chronic HIV infection is associated with both structural brain changes and social exclusion, the possibility that social experience may contribute to brain changes has not been studied in this population. Here, we aimed to estimate the direction and strength of the relationship between gray matter volume and social network size in older people living with HIV in Canada. Fifty-eight HIV + participants (3 women) from the Positive Brain Health Now cohort underwent structural brain imaging and reported the size of their social network. We tested the relationship between social network size and gray matter volume in key brain regions previously identified in healthy older adults. Negative correlations were observed between social network size and gray matter volume in all regions of interest, adjusting for age, education, and total intracranial volume. The strongest correlation was in the left anterior cingulate cortex. We found evidence that social network size is related to gray matter volume in brain regions involved in social behavior among older people, mostly men, with longstanding HIV infection. However, the direction of this effect was opposite to that predicted. This echoes some previous work in healthy male samples. These findings suggest the need to consider social as well as biological variables in studying the brain impacts of living with HIV. Further work is needed to clarify which social variables have the greatest influence, and how they affect the brain.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"647-654"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disruptions of resting-state functional connectivity in post-stroke motor dysfunctions: a meta-analysis.","authors":"Tingting Zhu, Jing Chen, Yanting Du, Tongyue Li, Xize Jia, Yating Lv","doi":"10.1007/s11682-025-00977-z","DOIUrl":"10.1007/s11682-025-00977-z","url":null,"abstract":"<p><p>This study aims to unravel the consistent abnormalities in functional connectivity (FC) with the primary motor cortex (M1) for post-stroke motor dysfunctions and the dynamic shifts of FC across distinct phases (acute/subacute/chronic) following stroke onset. Eleven studies with 269 stroke patients and 257 healthy controls (HCs) were included after screening articles in PubMed, Web of Science, and Embase. Voxel-wise meta-analysis and subgroup analysis on three phases after stroke onset were applied using the anisotropic effect size-signed differential mapping toolbox. Additionally, a M1-seeded FC analysis from an independent dataset with 29 stroke patients and 40 HCs was applied to validate the results of the meta-analyses. The abnormal connectivity with M1 in patients with post-stroke motor dysfunctions extended beyond motor-related regions to non-motor domains. A consistent interhemispheric connectivity reduction between M1 and motor-related regions emerged as a hallmark, persisting across different phases after stroke onset. These alterations were largely replicable through validation analysis. Our findings indicated the imbalance of connectivity in patients with post-stroke motor dysfunctions.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"771-784"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered cerebellar subregion functional connectivity and structure in patients with pediatric bipolar depression.","authors":"Yongming Tan, Hao Wang, Huifang Du, Yongjie Zhou, Mengqian Li, Laichang He","doi":"10.1007/s11682-025-00997-9","DOIUrl":"10.1007/s11682-025-00997-9","url":null,"abstract":"<p><p>To explore the structural and functional changes of Cerebellar Subregion in patients with pediatric bipolar disorder (PBD) patients and its clinical significance by using multimodal magnetic resonance imaging, so as to further explore the specific role of the cerebellum in PBD. This study included 48 pediatric patients with bipolar disorder (PBD) in the depressive phase from the outpatient clinic of the Department of Psychosomatic Medicine of the First Affiliated Hospital of Nanchang University. 22 healthy controls (HCs) matched for gender, age, handedness and education level were chosen from the community as the control group. All subjects underwent 3.0T resting-state functional magnetic resonance imaging (rs-fMRI) scans and completed clinical scales, including the Hamilton Depression Scale (HAMD) and Young Mania Rating Scale (YMRS). The cerebellum was categorized into 34 distinct subregions (R17, L17) based on SUIT and designated as seed points to perform whole-brain functional connectivity (FC). Group differences in categorical variables were assessed using the chi-square test, while continuous variables were compared employing the two-sample t-test. Correlations between FC and clinical parameters were analyzed for differential brain intervals. Compared with HCs, PBD patients in the depressive phase showed reduced FC between the left cerebellar lobules I-IV and the occipital inferior lobe (Occipital_Inf_L), cerebellar vermis VIIIa, and VIIIb; decreased FC between cerebellar cerebellar vermis VI and the frontal inferior orbital gyrus (Frontal_Inf_Orb_L), as well as the right cerebellar Crus 1; reduced FC between the left cerebellar Crus I and the dentate nucleus; decreased FC between cerebellar vermis VIIIa and the left superior frontal gyrus; reduced FC between the right cerebellar lobule IX and the right lingual gyrus; lowered FC between the left dentate and the dorsolateral prefrontal cortex, and the left lingual gyrus; FC between the left fastigial nucleus and the right cerebellar X decreased. Depressive phase of PBD patients exhibit altered functional connectivity within various subregions of the cerebellum, suggesting that the cerebellum is involved in central neural reorganization in PBD, which may be instructive for the understanding of central mechanisms and its future diagnostic and therapeutic target development.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"655-665"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biographical information influences on facial attractiveness judgment.","authors":"Sajina Rodríguez, Estefanía Hernández-Martín, Julio Plata-Bello","doi":"10.1007/s11682-025-01005-w","DOIUrl":"10.1007/s11682-025-01005-w","url":null,"abstract":"<p><p>In the realm of social cognition, facial perception is crucial, particularly in assessing facial attractiveness. This study investigated how biographical information impacts such evaluations. Two experiments were conducted: the first had participants rate 108 faces with and without biographical details, including occupation, psychiatric history, and politics. The second used fMRI to identify brain regions reacting differently with biographical information. Results showed that 31.48% of cases exhibited significant variations in facial evaluations when biographical information was introduced. The fMRI experiment highlighted heightened activity in the left Inferior Frontal Gyrus (IFG) and the left Middle Temporal Gyrus (MTG) when assessing facial attractiveness with biographical information, especially related to occupation or psychiatric history as opposed to politics. In summary, incorporating biographical information can substantially alter perceptions of facial attractiveness, engaging specific brain regions like the left IFG and left MTG. The results of this study could have significant implications for the understanding of social cognition and, among other aspects, for the destigmatization of personal histories in the field of mental health.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"746-758"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered functional connectivity within and between resting-state networks in ulcerative colitis.","authors":"Yanjun Ren, Kaizhong Xue, Huijuan Xu, Lijie Hao, Quchuan Zhao, Tianyu Chi, Hongwei Yang, Xiaojing Zhao, Defeng Tian, Huihong Zhai, Jie Lu","doi":"10.1007/s11682-025-01001-0","DOIUrl":"10.1007/s11682-025-01001-0","url":null,"abstract":"<p><p>Patients with ulcerative colitis (UC) often exhibit affective disorders, such as depression and anxiety. The underlying neurological mechanisms of these symptoms, however, remain poorly understood. This study aimed to explore alterations in functional connectivity (FC) both within and between resting-state networks (RSNs) in individuals with ulcerative colitis. Twelve meaningful RSNs were identified from 22 ulcerative colitis patients and 23 healthy controls using independent component analysis of functional magnetic resonance imaging data. Correlation analyses were performed between clinical indices, neuropsychological assessments and neuroimaging data. Compared with healthy controls, UC patients showed increased intranetwork FC, mainly located in the right temporal pole, orbitofrontal cortex, and left superior temporal and Rolandic opercular cortices within the auditory network. Increased intranetwork FC in the Rolandic opercular cortex was also observed in UC patients during remission phase, while no significant alterations were detected in patients with active-phase UC. In addition, UC patients exhibited increased connectivity between the dorsal attention and the left frontoparietal network, as well as between the anterior default mode network and the posterior default mode network, with distinct patterns of internetwork connectivity observed across different clinical phases. No significant correlations were found between altered brain regions and psychological scales in UC patients. These findings imply that UC patients may undergo functional network alterations, affecting both intranetwork connectivity within RSNs and internetwork connectivity between RSNs.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"702-712"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The neurobiology of motivational anhedonia in patients with depression.","authors":"Sigrid Breit, Niklaus Denier, Nicolas Mertse, Sebastian Walther, Leila M Soravia, Andrea Federspiel, Roland Wiest, Tobias Bracht","doi":"10.1007/s11682-025-00999-7","DOIUrl":"10.1007/s11682-025-00999-7","url":null,"abstract":"<p><p>Anhedonia is a core feature of depression. It contains a consummatory and a motivational aspect. Whilst much neuroimaging research in patients with depression focused on the consummatory aspect of anhedonia, less is known about its motivational aspect. This study aimed to explore the neurobiology of networks related to motivational anhedonia. Thirty-eight patients with major depressive disorder (MDD) and 19 healthy controls underwent diffusion-weighted and resting state functional magnetic resonance imaging (rs-fMRI). For assessment of motivational anhedonia, we summed the values of the CORE non-interactiveness score, and the items 1 (hopelessness) and 7 (work and activities) of the Hamilton Depression Rating Scale. Whole-brain voxel-wise statistical analysis of fractional anisotropy (FA) data was performed using Tract-Based Spatial Statistics (TBSS). Additionally, we performed a whole-brain comparison of integrated local correlation of rs-fMRI signal (LCOR), to investigate regional functional differences between patients and healthy controls. Whole brain correlations between motivational anhedonia and measures of structural and functional connectivity (FA, and LCOR) were calculated. TBSS-analyses revealed reduced FA in the left superior longitudinal fasciculus (SLF) in patients with MDD. LCOR was reduced in patients with depression in an adjacent cluster localized in bilateral precunei. Within patients, there was a positive correlation between motivational anhedonia and LCOR in the precunei and a negative correlation in bilateral sensorimotor areas. FA-values did not show significant correlations. These findings suggest that motivational anhedonia in depression is linked to alterations of functional connectivity within bilateral precunei. Observed white matter microstructural alterations in the SLF do not show such an association.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"690-701"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}