Brain Imaging and Behavior最新文献

{"title":"Comparison of the social gene expression network and social brain network: a resting-state functional magnetic resonance imaging study.","authors":"Yi-Jing Zhang, Hao-Yun Zhao, Peng Li, Xiao Lin, Lin Lu","doi":"10.1007/s11682-025-00993-z","DOIUrl":"10.1007/s11682-025-00993-z","url":null,"abstract":"<p><p>Numerous previous studies have classified brain regions related to social processing into the \"social brain\" regions. Recent genetic studies showed that gene expression has a crucial effect on both brain functions and behavioral social performance. However, studies still lack a clear understanding of the organization of the social gene expression (SocGene) network. This study aimed to distinguish the difference between the SocGene network and the social brain network (SBN) and further explored their deficits in schizophrenia (SCZ) patients. The SocGene network was constructed by generating the gene expression maps of six social neuropeptide receptors from the Allen Human Brain Atlas. Then, we recruited a general population sample of 37 participants and a clinical sample including 26 SCZ and 25 Healthy controls (HCs) successively to construct the resting-state SocGene and SBN at the individual level. The integration (global efficiency, GE) and segregation (local efficiency, LE) of these brain networks were calculated using the graphic analysis. Results showed that the GE and LE of the SocGene network were significantly higher than those of the SBN in both two cohorts. The SCZ patients showed significantly diminished LE of the two brain networks compared to HCs, especially in the SocGene network. These findings implied that the SocGene network strengthened the integration and segregation compared to the SBN. SCZ patients mainly exhibited deficits in the segregation of these two brain networks. The current findings provide a new perspective on combining genetic expression and brain function in understanding the psychopathology of social functioning.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"534-542"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional abnormalities of white and gray matter in youths with conduct problems.","authors":"Man Dong, Xiaodong Cheng, Yage Li, Shanling Ji, Hao Yu, Liangliang Ping, Chuanxin Liu, Cong Zhou","doi":"10.1007/s11682-025-00973-3","DOIUrl":"10.1007/s11682-025-00973-3","url":null,"abstract":"<p><p>Conduct problems (CP) encompass a wide array of behavioral difficulties in youths, including aggression, defiance, and rule-breaking, resulting in interpersonal conflicts. CP comprises various psychiatric conditions, constituting a significant public health burden. This study performed a whole-brain coordinate-based meta-analysis (CBMA) that synthesized findings from diffusion tensor imaging (DTI), voxel-based morphometry (VBM), and surface-based morphometry (SBM) studies to investigate consistent structural brain abnormalities in children and adolescents with CP. A total of 35 studies were eventually included. Altered white matter integrity in the right lenticular nucleus and the right inferior longitudinal fasciculus (ILF) were observed. Gray matter volume (GMV) alterations included increased volume in the right superior frontal gyrus, as well as reduced volume in the right supramarginal gyrus and left amygdala. Cortical thickness reductions were detected in the left precentral gyrus and right superior frontal gyrus. These findings underscored the intricate neurobiological basis of CP, and the meta-regression analysis revealed age-related variations in structural brain alterations, further highlighting the need for early and personalized interventions. This comprehensive study advanced our understanding of the neural underpinnings of CP, and future research and interdisciplinary collaboration to translate our findings into meaningful interventions for individuals with CP should be further explored.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"578-593"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered resting-state functional connectivity of amygdala subregions in adults with subthreshold depression after aerobic exercise.","authors":"Yihe Wang, Mengqi Zhao, Qin Li, Zeqi Hao, Jiaxi Zhang, Lina Huang, Qingguo Ding, Zhixiang Cheng, Jianxin Zhang, Huayun Li, Xize Jia","doi":"10.1007/s11682-025-00981-3","DOIUrl":"10.1007/s11682-025-00981-3","url":null,"abstract":"<p><p>Aerobic exercise has been proved to reduce the risk of major depression in subthreshold depression (StD) individuals effectively, yet previous studies ignored the different functions of amygdala subregions. In this study, 44 StD individuals and 34 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging before and after eight weeks of aerobic exercise respectively. Transverse and longitudinal analyses were conducted based on the seed-based functional connectivity (FC) analysis between amygdala subregions and the whole brain of the two groups. The transverse analyses showed that compared to HCs, StD individuals showed abnormal FC between the right dorsal amygdala (DA) and right superior frontal gyrus, the left medial amygdala (MA) and left gyrus rectus, right caudate, as well as the right ventrolateral amygdala (VA) and right angular gyrus before the exercise intervention, while increased FC between the right DA and left supramarginal gyrus after the exercise intervention. The longitudinal analysis showed decreased FC between the left DA and left caudate, left middle frontal gyrus, while increased FC between the right MA and posterior central gyrus in StD individuals after exercise intervention. As for HCs, the DA showed FC differences with the insula, frontal lobe, parietal lobe, temporal lobe and thalamus. The MA showed FC differences with the central posterior gyrus, occipital lobe and thalamus. The VA showed FC differences with the calcarine cortex and parietal lobe. The findings demonstrated the alleviative effect of aerobic exercise on depression from the perspective of brain function.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"468-484"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unique cortical morphology in young adults who are diagnosed with and medicated for attention-deficit/hyperactivity disorder.","authors":"Madeleine K Nowak, William G Kronenberger, Jiancheng Hou, Osamudiamen Ogbeide, Lillian M Klemsz, Hu Cheng, Sharlene D Newman, Keisuke Kawata","doi":"10.1007/s11682-025-00994-y","DOIUrl":"10.1007/s11682-025-00994-y","url":null,"abstract":"<p><p>Children diagnosed with attention-deficit/hyperactivity disorder (ADHD) often display reduced cortical volume and thickness, as well as changes in cortical folding. However, the impact of ADHD on cortical morphology in young adults remains elusive. This study aimed to characterize cortical thickness, gyrification, and sulcal depth profiles in adults aged 18-26 years old with ADHD. In this cross-sectional study, we employed multiparameter analyses between two groups: an ADHD group of individuals diagnosed with and medicated daily for ADHD (n = 30) and a non-ADHD group with age- and sex-matched individuals free from lifetime ADHD diagnosis (n = 30). The ADHD group exhibited significant cortical thinning in fronto-parieto-temporal regions, including the left superior parietal lobule, bilateral inferior temporal gyrus, and right lateral orbitofrontal gyrus, relative to the non-ADHD group. Greater gyrification and deeper sulcal depth were evident in various fronto-occipital-temporal regions in the ADHD group, although two regions (right postcentral and inferior temporal gyri) displayed shallower sulcal depth compared to the non-ADHD group. These data suggest that ADHD-related disparities persist into young adulthood, with alterations in brain morphology potentially serving as biomarkers for ADHD diagnosis in young adults.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"566-577"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma tryptophan levels are linked to hippocampal integrity and cognitive function in individuals with mild cognitive impairment.","authors":"Ali Azargoonjahromi","doi":"10.1007/s11682-025-00992-0","DOIUrl":"10.1007/s11682-025-00992-0","url":null,"abstract":"<p><p>Tryptophan has been shown to improve cognitive functions, but whether these benefits emanate from changes in hippocampal structure or other mechanisms like enhanced serotonin pathways remains unclear. This study aimed to examine the relationship between tryptophan levels and hippocampal volumes in individuals with mild cognitive impairment (MCI) and to determine if changes in hippocampal volume correlate with cognitive function. A total of 499 individuals with MCI were recruited based on ADNI's clinical criteria. Cognitive function was assessed using the ADAS-Cog scale, and hippocampal volumes were measured through MRI using semi-automated Medtronic Surgical Navigation Technologies (SNT). Tryptophan levels in plasma were analyzed using a nuclear magnetic resonance (NMR)-based assay. This study used two models: One unadjusted and another adjusted for covariates such as age, gender, handedness, and ApoE ɛ3 and ɛ4. In both models, higher tryptophan levels were significantly associated with increased bilateral hippocampal volumes, with a stronger effect in the left hippocampus. Furthermore, larger hippocampal volumes were linked to improved cognitive performance. Mediation analysis showed that hippocampal volumes mediated the relationship between plasma tryptophan levels and cognitive function. These findings suggested that elevated plasma tryptophan levels support cognitive health by maintaining hippocampal structural integrity, underscoring its potential role in preserving cognitive function in individuals with MCI.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"485-496"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations between postmortem quantitative MRI parameters and demyelination, axonal loss and gliosis in multiple sclerosis: A systematic review and meta-analysis.","authors":"Ting Shen, Samran Sheriff, Yanlin Qu, Vivek K Gupta, Stuart L Graham, Alexander Klistorner, Huixun Jia, Xiaodong Sun, Yuyi You","doi":"10.1007/s11682-025-00971-5","DOIUrl":"10.1007/s11682-025-00971-5","url":null,"abstract":"<p><p>Magnetic resonance imaging (MRI) is frequently used to monitor disease progression in multiple sclerosis (MS). This study aims to systematically evaluate the correlation between MRI measures and histopathological changes, including demyelination, axonal loss, and gliosis, in the central nervous system of MS patients. We systematically reviewed post-mortem histological studies evaluating myelin density, axonal loss, and gliosis using quantitative imaging in MS. Relevant studies were identified through searches in PubMed, EMBASE, and Web of Science. A total of 38 studies involving 1782 regions of interest from 229 subjects were included. Pooled random-effects models were used to calculate the correlation between demyelination, axonal loss, gliosis, and various MRI parameters, including magnetization transfer ratio (MTR), T1 and T2 relaxation times, myelin water fraction (MWF), proton density (PD), and diffusivities. Pair-wise analyses compared results between lesioned and non-lesioned tissues. Our results demonstrated moderate to strong correlations between MRI parameters and myelin density in MS, with correlation coefficients: T1 (0.72), T2 (0.72), MTR (-0.73), FA (-0.73), RD (0.70), MD (0.70), MWF (-0.82), and PD (0.73). Interestingly, stronger correlations were found in lesioned tissues compared to non-lesioned tissues (P < 0.001). Moderate correlations were found between MRI parameters and axonal loss and gliosis. Our study reveals significant correlations between MRI techniques and histological assessments of myelin, axonal damage, and gliosis in MS. MRI metrics exhibited a more robust association with demyelination in lesioned areas than in non-lesioned brain tissue, highlighting the pronounced degree of myelin degradation in MS lesions. Further investigation is warranted to corroborate these results and refine MRI-based monitoring of MS pathology.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"323-335"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced local functional connectivity correlates with atypical performances in children with autism spectrum disorder.","authors":"Fang Ye, Pianpian Hu, Aocai Yang, Lei Du, Xiaojing Xu, Jing Liu, Jixin Luan, Manxi Xu, Kuan Lv, Bing Liu, Kundi Wang, Yunfeng Wang, Ni Shu, Gaoxiang Ouyang, Hongwei Yu, Yuli Wang, Zhen Yuan, Amir Shmuel, Pengfei Xu, Qi Zhang, Guolin Ma","doi":"10.1007/s11682-025-00990-2","DOIUrl":"10.1007/s11682-025-00990-2","url":null,"abstract":"<p><p>To characterize local functional connectivity (FC) differences in children with autism spectrum disorder (ASD) compared to typically developed (TD) children, and to analyze the correlation between local FC and the atypical behavior in autistic children. Thirty children with ASD and 25 TD children were recruited. Participants underwent rs-fMRI scans, and regional homogeneity (ReHo) of specific brain regions was measured. Performance was assessed using the Autism Behavior Checklist (ABC) and the Gesell Development Diagnosis Scale (GDDS). Children with ASD demonstrated reduced ReHo in the right occipital lobe lingual, left postcentral, and left precuneus compared with TD children. Within the ASD group, the ABC total score was negatively related to ReHo values in both the left postcentral and left precuneus. The ReHo value in the left postcentral was negatively correlated with ABC scores related to sensory and body/object use, while the ReHo value in the left precuneus was negatively correlated with scores related to social skills and self-help. The mean Developmental Quotient (DQ) of GDDS was positively correlated with the ReHo value in the right occipital lobe lingual. Besides, the ReHo value in this region was positively correlated with the DQ of adaptive behavior. The ReHo value in the left postcentral was positively correlated with the DQ of fine motor skills (p < 0.05 for all). Children with ASD exhibit reduced local FC in specific brain regions, which are associated with specific performances in autism. These findings may provide a novel insight into the pathophysiological mechanisms of ASD.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"508-518"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11978534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-state connectivity enhancement in Aphasia patients post-speech therapy: a localization model.","authors":"Tao Feng, Chao Zhang, Weiwei Chen, Jie Zhou, Lu Chen, Lingmin Wang, Yanan Wang, Zhiyuan Xie, Siwei Xu, Jie Xiang","doi":"10.1007/s11682-025-00968-0","DOIUrl":"10.1007/s11682-025-00968-0","url":null,"abstract":"<p><p>Resting-state functional connectivity has become a valuable tool in studying post-stroke aphasia (PSA). However, the specific distribution of increased functional connectivity areas (IFCAs) in PSA patients after speech-language therapy (SLT) remains unclear, particularly compared with the intrinsic brain network (IBN) observed in healthy controls. This study aimed to explore the effects of SLT and spontaneous recovery on functional connectivity changes in the brain. We recruited twenty healthy controls and twelve PSA patients, each of whom underwent one month of SLT. The Chinese version of the Western Aphasia Battery (WAB) was administered to assess language function recovery. The Dice coefficients were calculated between each patient's lesion and the reference lesion, which showed moderate to high intensity. The results revealed a close association between the spatial distribution of IFCAs and improvements in specific language functions. Our findings indicate that the distribution pattern of IFCAs may serve as a significant marker of recovery in PSA patients.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"365-378"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential mechanism of impaired perceptual reasoning in children with obstructive sleep apnea syndrome: topological analysis of brain white matter network employing graph theory.","authors":"Weiting Tan, Shaojun Zhang, Xiaoyu Wang, Guisen Lin, Wenhong Ye, Hongwu Zeng","doi":"10.1007/s11682-025-00988-w","DOIUrl":"10.1007/s11682-025-00988-w","url":null,"abstract":"<p><p>Childhood obstructive sleep apnea syndrome (OSAS) disrupts normal ventilation and sleep structure and affects cognitive functions. However, the neurophysiological mechanisms underlying cognitive impairment are unclear. This study investigates the topological connectivity of white matter networks in children with moderate to severe OSAS and explores the underlying mechanisms of cognitive impairment. We collected clinical data of patients with moderate to severe OSAS (n = 43) and non-OSAS (n = 30). Intelligence testing was conducted using the China Wechsler Intelligence Scale for Children-Fourth Edition (C-WISC IV), including Processing speed, Working memory, Verbal comprehension, Perceptual reasoning, and Full-scale intelligence quotient (FSIQ). DTI data were collected using 3.0T MRI scanner (Ingenia, Philips, Netherlands). White matter network topology connections were analyzed using FSL and DSI Studio and inter group differences were statistically assessed. The difference of clinical and intelligence test was calculated by two sample t-test. Pearson correlation analysis was employed to examine the correlation between the abnormal white matter network metrics and cognitive function in OSAS patients. Clustering coefficient (Cp) and global efficiency (Eg), nodal degree (Dc), and nodal efficiency (Ne) were lower in the OSAS group (p < 0.05). Correlations between white matter network metrics and cognitive function: The Cp and Eg were positively correlated with Perceptual reasoning, and the shortest path length (Lp) was negatively correlated with Perceptual reasoning. The results indicate that there was impairment of cognitive function and abnormality of topological structural connectivity in white matter networks for children with OSAS. The Cp, Eg, and Lp correlate with Perceptual reasoning, indicating that abnormal topological structural connectivity of the white matter network might be neurofunctional basis for impaired perceptual reasoning.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"543-555"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural correlates of communication modes in medical students using fMRI.","authors":"Raluca Corina Oprea, Frederic Andersson, Valerie Gissot, Thomas Desmidt, Marta Siragusa, Laurent Barantin, Patrice Dubourg, Wissam El-Hage","doi":"10.1007/s11682-025-00985-z","DOIUrl":"10.1007/s11682-025-00985-z","url":null,"abstract":"<p><p>This study aims to determine if the six different types of communication (Directive, Imaginative, Reflective, Persuasive, Harmonizing, Promoting), as presented in the Process Communication Model, correlate with a respective neural pathway. Participants were 30 medical students with no past medical history. They underwent functional magnetic resonance imaging (fMRI) while watching videos typical of each communication type. By comparing each of the six experimental conditions with all the other ones, common activations were detected in the core memory network. Assertive communication styles (Directive, Imaginative) generated activations in conflict detection and resolution related areas, with a predominance in the frontal lobe. Emotive communication (Harmonizing, Promoting) highlighted activations associated with the interpretation of social and emotional cues, with a temporo-occipital predominance. There were no significant activations for the Reflective and Persuasive channel, the two channels that were most coherent with the subjects' base patterns and communication. This study indicated that out of the six communication types that were analyzed, four have a specific and congruous underlying cerebral process. This shows that neural response patterns vary across different communication styles, reflecting differences in cognitive and emotional processing.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"446-455"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}