White matter microstructural abnormalities related to emotional dysfunction and childhood trauma characterize adolescents with borderline personality disorder.

IF 2.4 3区医学 Q2 NEUROIMAGING

Brain Imaging and Behavior Pub Date : 2025-08-11 DOI:10.1007/s11682-025-01046-1

Xiaoping Yi, Xueying Wang, Liying Shen, Yan Fu, Qian Xiao, Jinfan Zhang, Jun Ding, Furong Jiang, Zhejia Zhang, Alessandro Grecucci, Bihong T Chen

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引用次数: 0

Abstract

Background: The neurobiological mechanism underlying adolescent borderline personality disorder (BPD) remains unclear. This study aimed to assess white matter (WM) microstructural abnormalities associated with emotional dysfunction and childhood trauma in adolescents with BPD.

Methods: This study enrolled 53 adolescents aged 12-17 years with BPD and 39 healthy controls (HC). Radial diffusivity (RD) and axial diffusivity (AD) were generated using Tract-Based Spatial Statistics (TBSS) analysis of the diffusion tensor imaging (DTI) data. Correlation analysis was conducted to assess the relationship of the DTI parameters with non-suicidal self-injurious behavior (NSSI) and childhood trauma in adolescents with BPD.

Results: Adolescents with BPD had lower AD values in the splenium of the corpus callosum, left anterior corona radiata and left external capsule, but higher RD values in the genu of the corpus callosum, body of the corpus callosum, right anterior corona radiata, and right uncinate fasciculus as compared to the HC group (p < 0.05, 5000 permutations). Increased RD values in the body of corpus callosum and right uncinate fasciculus were positively correlated with the NSSI score (p < 0.05). Increased RD value in the right anterior corona radiata was positively correlated with childhood trauma (p < 0.05).

Conclusions: This study identified alterations within the cortical-limbic system in adolescents with BPD, which was correlated with NSSI and childhood trauma. WM diffusivity parameters may serve as potential neuroimaging biomarkers in adolescents with BPD.

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与情绪障碍和童年创伤相关的白质微结构异常是边缘型人格障碍青少年的特征。

背景：青少年边缘型人格障碍（BPD）的神经生物学机制尚不清楚。本研究旨在评估青少年BPD患者与情绪功能障碍和童年创伤相关的白质（WM）微结构异常。方法：本研究招募了53名12-17岁的BPD青少年和39名健康对照（HC）。径向扩散系数（RD）和轴向扩散系数（AD）采用基于tractbased Spatial Statistics （TBSS）的方法对扩散张量成像（DTI）数据进行分析。通过相关分析评估DTI参数与青少年BPD非自杀自伤行为（NSSI）和童年创伤的关系。结果：与HC组相比，青少年BPD患者胼胝体脾脏、左侧前放射冠和左侧外囊的AD值较低，但胼胝体膝、胼胝体体、右侧前放射冠和右侧扣带束的RD值较高(p)。结论：本研究发现青少年BPD患者皮质边缘系统的改变与自伤和童年创伤有关。WM扩散参数可能作为青少年BPD的潜在神经成像生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Imaging and Behavior 医学-神经成像

CiteScore

7.20

自引率

0.00%

发文量

154

审稿时长

3 months

期刊介绍： Brain Imaging and Behavior is a bi-monthly, peer-reviewed journal, that publishes clinically relevant research using neuroimaging approaches to enhance our understanding of disorders of higher brain function. The journal is targeted at clinicians and researchers in fields concerned with human brain-behavior relationships, such as neuropsychology, psychiatry, neurology, neurosurgery, rehabilitation, and cognitive neuroscience.