Brain Imaging and Behavior最新文献

{"title":"Mindful young brains and minds: a systematic review of the neural correlates of mindfulness-based interventions in youth.","authors":"Jovan Jande, Isaac N Treves, Samantha L Ely, Leah C Gowatch, Carmen Carpenter, MacKenna Shampine, Christian A Webb, Matthew D Sacchet, John D E Gabrielli, Hilary A Marusak","doi":"10.1007/s11682-025-00989-9","DOIUrl":"10.1007/s11682-025-00989-9","url":null,"abstract":"<p><p>This systematic narrative review examines neuroimaging studies that investigated the neural correlates of mindfulness-based interventions in youth (ages 0-18). We extracted 13 studies with a total of 467 participants aged 5-18 years from the MEDLINE database on February 21st, 2024. These studies included both typically developing youth and those at risk of developing or recovering from neuropsychiatric disorders. Most studies (76.9%) utilized a pre-post intervention design, with resting-state functional magnetic resonance imaging (fMRI) being the most common imaging modality (46.1%), followed by task-based fMRI (38.4%), diffusion-weighted imaging (15.4%), and structural MRI (7.7%). Despite substantial heterogeneity across study designs and findings, several consistent patterns emerged. Resting-state fMRI studies generally reported increased functional connectivity within and between networks, notably involving the salience network, frontoparietal network, and default mode network. Studies using diffusion-weighted imaging indicated enhancements in white matter microstructural properties, supporting overall connectivity improvements. Several task-based fMRI studies identified decreased activation of the default mode network and heightened reactivity of the salience network during or after mindfulness practice, with real-time neurofeedback further amplifying these effects. While preliminary, the reviewed studies suggest that mindfulness interventions may alter both functional and structural connectivity and activity in youth, potentially bolstering self-regulation and cognitive control. Nonetheless, the variability in methodologies and small sample sizes restricts the generalizability of these results. Future research should prioritize larger and more diverse samples, and standardized mindfulness-based interventions to deepen our understanding of the neural mechanisms underlying mindfulness-based interventions in youth and to optimize their efficacy.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"609-625"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated vascular endothelial growth factor a is associated with disruption of default network connectivity in older adults.","authors":"Arunima Kapoor, Jung Yun Jang, Allison C Engstrom, Trevor Lohman, Shubir Dutt, John Paul M Alitin, Isabel J Sible, Anisa Marshall, Fatemah Shenasa, Aimee Gaubert, Amy Nguyen, David Robert Bradford, Kathleen Rodgers, S Duke Han, Daniel A Nation","doi":"10.1007/s11682-025-00969-z","DOIUrl":"10.1007/s11682-025-00969-z","url":null,"abstract":"<p><p>Vascular Endothelial Growth Factor A (VEGF-A) is an angiogenic signaling protein involved in the maintenance of the cerebral vasculature. No prior study has explored whether plasma VEGF-A levels may be associated with brain functional connectivity changes, such as disruption of the default mode network (DMN), which often precedes the development of cognitive changes in aging. Seventy-six independently living older adults (mean age = 70.3 years; SD = 7.5; 31.6% male) free of dementia or clinical stroke underwent venipuncture and brain MRI. Plasma was assayed for VEGF-A. Using resting state functional MRI, region of interest (ROI) to ROI connectivity and graph theory analysis were conducted to determine average connectivity and global efficiency between each of the following ROIs comprising the DMN: medial prefrontal cortex, lateral parietal cortex and precuneus cortex. Multiple linear regression analysis revealed a significant negative association between VEGF-A levels and DMN connectivity (B = - 0.14, 95% CI (-0.26, - 0.01), p =.038), accounting for age, sex, education, and vascular risk factors. Graph theory analysis similarly revealed that VEGF-A levels are associated with global efficiency of the entire network (B = - 0.18, p =.004). These findings suggest that VEGF-A may be elevated early in the progression of neurocognitive disorders. Whether higher levels of VEGF-A contribute to the pathogenesis of neurocognitive disorders or play a protective role in preserving cognitive function warrants further investigation. Clinical Trial Number: N/A; None.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"379-383"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11978527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered brain glucose metabolism in COVID-19 disease: an activation likelihood estimation meta-analysis of PET studies.","authors":"Dongju Kang, Hyunji Jung, Kyoungjune Pak","doi":"10.1007/s11682-025-00966-2","DOIUrl":"10.1007/s11682-025-00966-2","url":null,"abstract":"<p><p>COVID-19 disease, caused by the SARS-CoV-2 virus, has significantly altered modern society and lifestyles. We investigated its impact on brain glucose metabolism by meta-analyzing existing studies that utilized 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) scans of the brain. We conducted a systematic search of MEDLINE and EMBASE databases from inception to August 2024 for English-language publications using the keywords \"positron emission tomography\", and \"COVID-19\". We included original research articles that reported changes in brain glucose metabolism following COVID-19 disease. ALE values from these studies were aggregated and tested against a null hypothesis that anticipated a random distribution of ALE values, which proved to be significantly higher than chance. We identified nine papers that met our inclusion criteria. Significant increases in brain glucose metabolism were noted in the left anterior cingulate gyrus, right thalamus, and brainstem. In children with COVID-19 disease, decreased glucose metabolism was observed in the right and left cerebellum, left amygdala/hippocampus, left anterior cingulate gyrus, and right amygdala. In adults with COVID-19 disease, decreased metabolism was seen in the right temporal lobe, brainstem (acute phase), left occipital lobe, left and right temporal lobe (chronic phase). In conclusion, COVID-19 disease impacts brain glucose metabolism, typically manifesting as areas of decreased metabolism in ¹⁸F-FDG PET scans, though increases are also observed. These changes in metabolism vary with the patient's age and the time elapsed between the diagnosis of COVID-19 disease and the PET scan.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"313-322"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring neuroanatomy and neuropsychology in digital financial decision-making: betrayal aversion and risk behavior.","authors":"Santiago Carbó-Valverde, Raquel Martín-Ríos, Francisco Rodríguez-Fernández","doi":"10.1007/s11682-025-00967-1","DOIUrl":"10.1007/s11682-025-00967-1","url":null,"abstract":"<p><p>Detecting the factors associated with financial decision-making is an unresolved challenge when trying to predict digital financial behavior. This paper reports experimental results on both neuropsychological and neuronal correlates of risk-taking and betrayal aversion among 121 healthy participants (X_age=21.7; SD = 2.8). A questionnaire on financial habits was administered, followed by neuropsychological tests and a magnetic resonance imaging session while participants viewed videos depicting both traditional and digital economic transactions. Participants also completed a computerized version of trust and risk games. Results reveal that Sensitivity to Punishment and Negative Urgency significantly predict risk behavior. High betrayal aversion was associated with greater sensitivity to punishment as well as lower volume in temporal areas. Cluster analysis identified two distinct psychological profiles based on betrayal aversion scores, highlighting differences in sensitivity to punishment, negative urgency, positive urgency, and trust game score. Furthermore, cortical thickness comparisons revealed differences between low and high-aversion groups, particularly in the temporal, parietal, and insular areas. White matter analysis indicated less integration in specific tracts among individuals with high betrayal aversion. These findings suggest the influence of neuropsychological factors on the adoption of risky financial behaviors and emotional response to betrayal.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"357-364"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11978724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampal network connectivity and episodic memory in individuals aging with traumatic brain injury.","authors":"Catherine M Carpenter, Hollie A Mullin, Andrew Cwiek, Emily Carter, Samantha Vervoordt, Xinhui Lan, Nancy A Dennis, Amanda Rabinowitz, Umesh M Venkatesan, Frank G Hillary","doi":"10.1007/s11682-025-00979-x","DOIUrl":"10.1007/s11682-025-00979-x","url":null,"abstract":"<p><p>Aging is associated with marked declines in episodic memory corresponding with decreased volume in studies of morphology and reduced network response in studies of functional connectomics. Furthermore, recent research has demonstrated that reductions in resting state network connectivity are related to declines in episodic memory, specifically in the default mode and frontoparietal cortical networks. Additionally, the interactive effects of aging and traumatic brain injury (TBI) are associated with increased risk for neurodegeneration and episodic memory impairments. However, there is a gap in the literature examining episodic memory and hippocampal-subcortical resting state connectivity differences related to aging with and without TBI. The current work aims to investigate episodic memory differences between older adults with TBI (N = 45) and older adults with no history of TBI (N = 28) and how that relates to hippocampal-subcortical network differences at rest. We demonstrate a positive relationship between default mode and frontoparietal network connectivity and memory performance differentially between those aging with and without moderate-severe TBI (msTBI). Additionally, we demonstrate that reliability in the strength of resting state functional connectivity between parcellations is weakest among connections to the hippocampus compared to other cortical connections but is generally reliable across other connections.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"433-445"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional connectivity and white matter microstructural alterations in patients with left basal ganglia acute ischemic stroke.","authors":"Meizhong Chen, Yufan Wu, Yuntao Wang, Zhongming Li","doi":"10.1007/s11682-025-00982-2","DOIUrl":"10.1007/s11682-025-00982-2","url":null,"abstract":"<p><p>Lesions in the basal ganglia present different neuroimaging manifestations compared to other regions. The functional connectivity and white matter (WM) microstructural alterations in patients with left basal ganglia acute ischemic stroke (AIS) remain unknown. This study aimed to explore the alterations of functional connectivity and WM microstructure, as well as their relationship with cognitive performance in patients with left basal ganglia AIS. We acquired resting-state functional MRI (rs-fMRI) and diffusion kurtosis imaging (DKI) data from 41 individuals with left basal ganglia AIS and 41 healthy controls (HC). The degree centrality (DC) method was applied to calculate the functional connectivity and Tract-Based Spatial Statistics was employed to evaluate the voxel-based group differences of diffusion metrics for the values of fractional anisotropy (FA), mean diffusivity, axial diffusivity (AD), radial diffusivity, mean kurtosis (MK), axial kurtosis, and radial kurtosis (RK). AIS showed attenuated DC in the bilateral precuneus and enhanced DC in the left caudate nucleus, compared with HC. In AIS, DC in the left caudate nucleus correlated positively with the Montreal Cognitive Assessment (MoCA) score (r = 0.681, p < 0.05). AIS had significantly decreased FA, AD, MK, and RK in WM tracts, including the internal capsule (IC), genu of corpus callosum (CC), body of CC, left superior longitudinal fasciculus (SLF), left cerebral peduncle, left corticospinal tract, anterior corona radiata (ACR), and left cingulum gyrus (CG). The MK in a cluster including the body of CC, right IC, left cingulate, SLF, ACR, and left CG was also significantly negatively correlated with MoCA scores (r = -0.508, p < 0.05). This study revealed that left basal ganglia AIS not only disrupted the functional connectivity of the whole brain but also had a pervasive impact on the WM microstructure of the whole brain. These findings provide novel insights into the underlying neural mechanisms of early cognitive decline in patients after AIS.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"421-432"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal network homogeneity in patients with bipolar disorder in attention network.","authors":"Mengling Tan, Yunxiao Guo, Sijun Liu, Wei Liu, Liang Cheng, Yujun Gao, Zhihong Ren","doi":"10.1007/s11682-025-00974-2","DOIUrl":"10.1007/s11682-025-00974-2","url":null,"abstract":"<p><p>Bipolar disorder (BD) is a complex psychiatric condition marked by significant mood fluctuations that deeply affect quality of life. Understanding the neural mechanisms underlying BD is critical for improving diagnostic accuracy and developing more effective treatments. This study utilized resting-state functional magnetic resonance imaging (rs-fMRI) to investigate functional connectivity within the ventral and dorsal attention networks in 52 patients with BD and 51 healthy controls. Independent Component Analysis (ICA) was employed to establish network templates, while Network Homogeneity (NH) analysis facilitated the comparison of NH values across various brain regions. We examined the association of NH values with clinical measures, including the Hamilton Depression Scale, Perceptual Deficit Questionnaire, and Young Mania Scale. Results indicated that BD patients exhibited lower NH values in the right inferior temporal gyrus of the dorsal attention network and the right middle temporal gyrus of the ventral attention network compared to controls. Notably, NH values in the right superior marginal gyrus of the ventral network were higher in the BD group. Although no significant correlations were found between NH values and clinical symptoms, Support Vector Machine (SVM) analysis demonstrated over 60% accuracy in differentiating BD patients based on NH values. These findings highlight the potential of NH measures as biomarkers for BD, underscore the importance of advanced neuroimaging in uncovering the disorder's complex neural dynamics, and point to the challenges and need for further research to improve predictive accuracy.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"336-345"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network dynamics in post-stroke cognitive impairment: insights from effective connectivity analysis.","authors":"Zhao Ruan, Xiaoli Zhou, Bo Rao, Yidan Li, Wenbo Sun, Tianliang Li, Lei Gao, Haibo Xu","doi":"10.1007/s11682-025-00972-4","DOIUrl":"10.1007/s11682-025-00972-4","url":null,"abstract":"<p><p>This study investigates post-stroke cognitive impairment (PSCI) by utilizing spectral dynamic causal modeling (spDCM) to examine changes in effective connectivity (EC) within the default mode, executive control, dorsal attention, and salience networks. Forty-one PSCI patients and 41 demographically matched healthy controls underwent 3D-T1WI and resting-state functional magnetic resonance imaging on a 3.0T MRI. The study compared EC among eight representative regions of interest using spDCM and analyzed the correlation between altered EC and cognitive test scores. Subgroup analysis was conducted based on lesion location. The study found a significant increase in EC in the PSCI group, specifically from the posterior cingulate cortex (PCC) to the left and right dorsolateral prefrontal cortex (L_DLPFC and R_DLPFC, respectively), and from the right insula to R_DLPFC (p < 0.05). These changes were significantly negatively correlated with cognitive scores. Subgroup analysis showed increased executive control in PSCI patients with left anterior circulation lesions. Validation through low-order functional connectivity analysis indicated abnormalities dominated by large-scale intra- and inter-network functional connectivity increases in patients with PSCI. The study suggests an increase in effective connectivity between networks, particularly within the triple network model. The findings implicate the PCC and R_DLPFC in the pathophysiology of PSCI, shedding light on its cognitive implications. This study emphasizes the importance of understanding network changes in PSCI from various perspectives, enhancing our understanding of the neural mechanisms underlying PSCI, and establishing a foundation for future research.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"346-356"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional high iron deposition on brain quantitative susceptibility mapping correlates with cognitive decline in chronic kidney disease patients.","authors":"Yuan Li, Yuhan Jiang, Bingbing Gao, Na Liu, Yukun Zhang, Huiling Zhou, Qingwei Song, Nan Wang, Yanwei Miao","doi":"10.1007/s11682-025-00976-0","DOIUrl":"10.1007/s11682-025-00976-0","url":null,"abstract":"<p><p>This study aimed to evaluate changes in gray matter nuclei iron deposition in chronic kidney disease (CKD) patients using the quantitative susceptibility mapping (QSM) threshold method, and analyze the relationship between brain iron levels and cognitive function. A total of fifty-three CKD patients were prospectively recruited, comprising 35 hemodialysis (HD, 57.54 ± 10.42 years, 21 males) and 18 non-hemodialysis (NHD, 55.06 ± 11.47 years, 10 males ), and were compared to 43 healthy controls (HC, 55.67 ± 7.79 years, 18 males). All participants underwent clinical assessments, neuropsychological tests, and QSM scans. The mean magnetic susceptibility value (MSV) and volume of the whole nuclei (MSV_M, V_M) and high iron region (MSV_RII, V_RII) were measured. Correlations between QSM data, neuropsychological scores, and clinical variables in HD group were analyzed. Linear regression analysis was performed to explore the effect of iron deposition on cognition and emotional well-being in HD group. A statistically significant P-value was set at 0.05. HD patients exhibited higher MSV_M in the right red nucleus (RN) compared to HCs (P = 0.006). Additionally, significant differences in the MSV_RII were observed in the left caudate nucleus (CN), bilateral putamen (Put), and right RN among the three groups (all P = 0.027, FDR-corrected). MSV_RII of the left Put was positively correlated with creatinine and uric acid levels, while the MSV_RII of the right Put was negatively correlated with mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration. Regression analysis revealed that iron deposition in left CN was independently associated with depression, while iron deposition in left Put and right RN were independently positively associated with delayed recall performance. Conversely, iron deposition in bilateral Put and right RN were negatively associated with orientation ability, after controlling for age, sex, years of education and duration of dialysis. Brain iron deposition is often excessive and uneven in CKD patients, particularly those undergoing hemodialysis. Assessing regional high-iron deposition can provide valuable insights into the distribution of iron, which is associated with cognitive dysfunction and emotional disorders.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"395-406"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11978685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aberrant functional connectivity patterns in the pregenual anterior cingulate cortex and anterior midcingulate cortex of patients with irritable bowel syndrome accompanied by depressive symptoms.","authors":"Ruoyu Tang, Yihan Jin, Kuanghui Xu, Liqiang Wu, Xiaofei Chen, Yun Guo, Guodong Li, Jie Li","doi":"10.1007/s11682-024-00964-w","DOIUrl":"10.1007/s11682-024-00964-w","url":null,"abstract":"<p><p>Irritable bowel syndrome (IBS) is a common brain-gut disorder often accompanied by depressive symptoms, with atrophy and hyperactivity of the anterior cingulate gyrus (ACC) being key drivers of both IBS and its psychiatric comorbidities. This study aimed to investigate the functional connectivity (FC) patterns of pregenual ACC (pgACC) and anterior midcingulate cortex (aMCC) in IBS patients with depressive symptoms (DEP-IBS). A whole-brain FC analysis was conducted using pgACC and aMCC as regions of interest in three groups: 28 DEP-IBS patients, 21 IBS patients without depressive symptoms (nDEP-IBS), and 36 matched healthy controls (HCs). Partial correlation and mediation analyses were performed between abnormal FC and clinical symptoms. The ability of aberrant FC to identify IBS and its psychiatric comorbidity was evaluated using receiver operating characteristic (ROC) curve. DEP-IBS patients exhibited increased pgACC-related FC in the left medial prefrontal cortex (mPFC) and aMCC-related FC in the right middle frontal gyrus, angular gyrus and cerebellum, while showing decreased aMCC-related FC in the right precentral gyrus, superior parietal gyrus and precuneus. Both patient groups demonstrated increased FC between aMCC and left dorsolateral prefrontal cortex (dlPFC), effectively distinguishing them from HCs (AUC = 0.755). The FC between pgACC and left mPFC partially mediated the relationship between gastrointestinal and depressive symptoms, effectively distinguishing DEP-IBS from nDEP-IBS patients (AUC = 0.808). Aberrant FC within the emotional arousal network may serve as a neurobiological marker for IBS with comorbid depression. Furthermore, abnormal FC between the aMCC and the dlPFC may underlie the neural mechanism of IBS.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"279-290"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}