Brain Imaging and Behavior最新文献_第8页

Abnormal percent amplitude of fluctuation in patients with lifelong premature ejaculation is associated with neurotransmitter profiles. 终生早泄患者异常的百分比波动幅度与神经递质特征有关。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-02-01 Epub Date: 2024-10-25 DOI: 10.1007/s11682-024-00920-8

Jiarui Yuan, Pinxiao Wang, Dingxin Nie, Wanxiang Zheng, Kepu Liu, Jianyong Feng, Yuntao Zhang, Yanzhu Wang, Junjun Gao, Ming Gao

{"title":"Abnormal percent amplitude of fluctuation in patients with lifelong premature ejaculation is associated with neurotransmitter profiles.","authors":"Jiarui Yuan, Pinxiao Wang, Dingxin Nie, Wanxiang Zheng, Kepu Liu, Jianyong Feng, Yuntao Zhang, Yanzhu Wang, Junjun Gao, Ming Gao","doi":"10.1007/s11682-024-00920-8","DOIUrl":"10.1007/s11682-024-00920-8","url":null,"abstract":"Identifying additional imaging biomarkers of lifelong premature ejaculation (LPE) may provide valuable insights into understanding the underlying neural mechanisms of this disorder. Forty-six LPE patients and thirty-five healthy controls (HCs) were enrolled in this study. The Percent Amplitude of Fluctuation (PerAF) method was used to assess differences in brain function in LPE patients compared to HCs during the resting-state. Receiver operating characteristic (ROC) analysis was used to investigate the potential biomarkers based on the imaging findings. Correlation analysis was then applied to examine the relationships between the neuroimaging findings and clinical symptoms. We also investigated whether PerAF alterations in LPE patients were associated with specific neurotransmitter systems. Compared to HCs, LPE patients showed increased PerAF in the middle cingulate cortex (MCC), supramarginal gyrus, Rolandic operculum, parahippocampus/hippocampus (ParaHIPP/HIPP) as well as insula; and decreased PerAF in the precuneus, inferior temporal cortex plus occipital cortex. The MCC and ParaHIPP/HIPP exhibited higher classification performance on ROC analysis. Positive correlations were found between the Premature Ejaculation Diagnostic Tool score and PerAF in the insula, and the International Index of Erectile Function score and PerAF in the precuneus. Additionally, altered PerAF in LPE patients correlated significantly with the spatial distribution of dopamine, acetylcholine and epinephrine pathways. Our findings indicate that LPE patients have PerAF-related changes in certain brain regions associated with visual, sensory and/or emotional processing, and reveal that the abnormal control of ejaculatory function may be related to the combined dysregulation of neurotransmitter systems in LPE patients.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"41-49"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between precuneus cortex thickness and mild behavioral impairment in patients with mild stroke. 轻度脑卒中患者楔前皮层厚度与轻度行为障碍之间的关系。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-02-01 Epub Date: 2024-11-12 DOI: 10.1007/s11682-024-00955-x

Zhengxin Liu, Ziwei Xu, Aijuan Yan, Panpan Zhang, Wenshi Wei

{"title":"The association between precuneus cortex thickness and mild behavioral impairment in patients with mild stroke.","authors":"Zhengxin Liu, Ziwei Xu, Aijuan Yan, Panpan Zhang, Wenshi Wei","doi":"10.1007/s11682-024-00955-x","DOIUrl":"10.1007/s11682-024-00955-x","url":null,"abstract":"The objective of this research was to examine the association between precuneus cortex thickness and mild behavioral impairment (MBI) in patients with mild stroke. Seventy-two patients were evaluated by high-resolution 3 T magnetic resonance and the mild behavioral impairment checklist (MBI-C). To determine the association between precuneus cortex thickness and MBI, we adjusted for demographics, vascular risk factors, and laboratory examination indicators in logistic regression analysis. In addition, we used mendelian randomization to further study the association through genetic databases. Of the 72 mild stroke patients in this study, 26 had MBI. We found a strong negative connection between precuneus cortex thickness and MBI after adjusting for any confounding variables. In patients with an initial mild stroke, the thinner the precuneus cortex, the higher the risk of MBI (OR: 0.02; 95% CI: 0.00-0.39; P < 0.05). Our study has uncovered a significant negative association between the thickness of the precuneus cortex and MBI. This finding provides a novel viewpoint for the radiological diagnosis of MBI, thereby augmenting the contribution of imaging to the diagnostic process of MBI and advancing the prediction of dementia. Specifically, in patients who have suffered mild stroke, a reduction in the cortical thickness of the precuneus has been pinpointed as crucial radiographic evidence of preclinical cognitive impairment. This insight could potentially facilitate earlier detection and intervention strategies for cognitive decline.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"99-110"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large-scale structural covariance networks changes relate to executive function deficit in betel quid-dependent chewers. 大规模结构协方差网络变化与槟榔依赖咀嚼者的执行功能缺陷有关。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-02-01 Epub Date: 2024-10-19 DOI: 10.1007/s11682-024-00950-2

Yihao Guo, Tao Liu, Xiaoling Xu, Tiansheng Li, Xiaoli Xiong, Huijuan Chen, Weiyuan Huang, Xianchang Zhang, Feng Chen

{"title":"Large-scale structural covariance networks changes relate to executive function deficit in betel quid-dependent chewers.","authors":"Yihao Guo, Tao Liu, Xiaoling Xu, Tiansheng Li, Xiaoli Xiong, Huijuan Chen, Weiyuan Huang, Xianchang Zhang, Feng Chen","doi":"10.1007/s11682-024-00950-2","DOIUrl":"10.1007/s11682-024-00950-2","url":null,"abstract":"Previous studies demonstrate deficits in executive function for betel quid-dependent (BQD) patients. Large-scale structural covariance network (SCN) based on gray matter (GM) morphometry may be able to explore the neural mechanism of executive dysfunction in BQD individuals. This study aims to identify spatial covariance patterns of GM volume and to investigate their association with executive dysfunction in BQD individuals. Sixty-four BQD individuals and 48 sex- and age-matched healthy controls (HCs) underwent T1-weighted structural MRI examination and executive function assessments, including the Backward Digit Span (BDS) test and Stroop Color and Word (SCW) test. Seventy SCNs based on GM volume covariance patterns were defined using independent component analysis. An SCN-based classifier was constructed to differentiate between BQD and HC individuals. Receiver operating characteristic (ROC) curves were applied to evaluate the performance of the SCN-based classifier. Linear regression analyses were performed to investigate the association between SCN network indices and executive function indices. Six SCNs had higher classifications for differentiating between BQD and HC individuals. The area under the ROC curve of the SCN-based classifier was 0.812 in the training set and 0.771 in the testing set. Furthermore, linear regression analyses demonstrated that the network indices in the thalamus were associated with BDS scores adjusted for age, sex, and education. Large-scale SCNs could provide potential imaging markers for differentiating BQD and HC groups. The loss of network index in the thalamus was associated with working memory, indicating that SCNs could reveal executive dysfunction in BQD individuals.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"32-40"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of depression severity on interhemispheric functional integration: an analysis from the REST-meta-MDD database. 抑郁症严重程度对大脑半球间功能整合的影响：来自REST-meta-MDD数据库的分析

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-02-01 Epub Date: 2024-11-30 DOI: 10.1007/s11682-024-00960-0

Jie Ding, Junfeng Peng, Qian Zhang

{"title":"Influence of depression severity on interhemispheric functional integration: an analysis from the REST-meta-MDD database.","authors":"Jie Ding, Junfeng Peng, Qian Zhang","doi":"10.1007/s11682-024-00960-0","DOIUrl":"10.1007/s11682-024-00960-0","url":null,"abstract":"Major depressive disorder (MDD) is a pervasive mental disorder that significantly impairs functional capabilities, underscoring the necessity for precise stratification of its severity to facilitate tailored treatment. This study investigated the utility of voxel-mirrored homotopic connectivity (VMHC) derived from resting-state functional magnetic resonance imaging (fMRI) data as a neuroimaging biomarker to differentiate varying severities of MDD in a sample drawn from the REST-meta-MDD project, which included 392 first-episode MDD patients and 440 healthy controls (HC) from 9 sites. Patients were classified into mild to moderate and severe depression groups according to the 17-item Hamilton Depression Scale (HAMD) scores. VMHC differences between these subgroups and their associations with HAMD scores were further examined. The results revealed significant reductions in VMHC within the fusiform gyrus for patients with mild to moderate depression compared to HCs, alongside more extensive reductions across the insula, postcentral gyrus, and angular gyrus in severe depression. Notably, increased VMHC in the middle cingulate cortex was identified in severe MDD patients relative to those with mild to moderate depression, with this increase showed a significant positive correlation with the HAMD scores. Additionally, receiver operating characteristic (ROC) curve analysis demonstrated that VMHC values in these regions effectively differentiate patients from HCs and across varying severities of MDD. These findings suggest that VMHC could serve as a valuable metric for clinical diagnosis and the stratification of depression severity, providing insights into the underlying neurobiological mechanisms associated with the disorder.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"148-158"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain connectomes in youth at risk for serious mental illness: a longitudinal perspective. 严重精神疾病高危青少年的大脑连接体：纵向视角。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-02-01 Epub Date: 2024-11-08 DOI: 10.1007/s11682-024-00953-z

Mohammed K Shakeel, Paul D Metzak, Mike Lasby, Xiangyu Long, Roberto Souza, Signe Bray, Benjamin I Goldstein, Glenda MacQueen, JianLi Wang, Sidney H Kennedy, Jean Addington, Catherine Lebel

{"title":"Brain connectomes in youth at risk for serious mental illness: a longitudinal perspective.","authors":"Mohammed K Shakeel, Paul D Metzak, Mike Lasby, Xiangyu Long, Roberto Souza, Signe Bray, Benjamin I Goldstein, Glenda MacQueen, JianLi Wang, Sidney H Kennedy, Jean Addington, Catherine Lebel","doi":"10.1007/s11682-024-00953-z","DOIUrl":"10.1007/s11682-024-00953-z","url":null,"abstract":"Identifying biomarkers for serious mental illnesses (SMI) has significant implications for prevention and early intervention. In the current study, changes in whole brain structural and functional connectomes were investigated in youth at transdiagnostic risk over a one-year period. Based on clinical assessments, participants were assigned to one of 5 groups: healthy controls (HC; n = 33), familial risk for serious mental illness (stage 0; n = 31), mild symptoms (stage 1a; n = 37), attenuated syndromes (stage 1b; n = 61), or discrete disorder (transition; n = 9). Constrained spherical deconvolution was used to generate whole brain tractography maps, which were then used to calculate connectivity matrices for graph theory analysis. Graph theory was also used to analyze correlations of functional magnetic resonance imaging (fMRI) signal between pairs of brain regions. Linear mixed models revealed structural and functional abnormalities in global metrics of small world lambda, and resting state networks involving the fronto-parietal, default mode, and deep grey matter networks, along with the visual and dorsal attention networks. Machine learning analysis additionally identified changes in nodal metrics of betweenness centrality in the angular gyrus and bilateral temporal gyri as potential features which can discriminate between the groups. Our findings further support the view that abnormalities in large scale networks (particularly those involving fronto-parietal, temporal, default mode, and deep grey matter networks) may underlie transdiagnostic risk for SMIs.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"82-98"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuromelanin-MRI identifies locus coeruleus and substantia nigra degeneration as key differentiators in isolated rapid eye movement sleep behavior disorder. 神经黑素-核磁共振成像（Neuromelanin-MRI）确定黑质和黑质变性是孤立性快速眼动睡眠行为障碍的关键分化因素。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-02-01 Epub Date: 2024-10-30 DOI: 10.1007/s11682-024-00926-2

Junyan Fu, Ye Tang, Lei Pan, Kun Lv, Xin Cao, Siting Xu, Daoying Geng, Huan Yu, Jun Zhang

{"title":"Neuromelanin-MRI identifies locus coeruleus and substantia nigra degeneration as key differentiators in isolated rapid eye movement sleep behavior disorder.","authors":"Junyan Fu, Ye Tang, Lei Pan, Kun Lv, Xin Cao, Siting Xu, Daoying Geng, Huan Yu, Jun Zhang","doi":"10.1007/s11682-024-00926-2","DOIUrl":"10.1007/s11682-024-00926-2","url":null,"abstract":"To explore the neuromelanin depigmentation of locus coeruleus (LC) and substantia nigra pars compacta (SNc) in the isolated rapid eye movement sleep behavior disorder (iRBD) using neuromelanin-sensitive MRI (NM-MRI), and to evaluate its utility for iRBD diagnosis. A total of 25 iRBD patients and 25 healthy controls were recruited and underwent NM-MRI. The contrast-to-noise ratio (CNR) of SNc and LC, and the volume of SNc were compared between groups and evaluated visually. The power of NM measures in discriminating iRBD patients from healthy controls were performed with receiver operating characteristic (ROC) curves and the area under curve (AUC) was calculated. The CNR of SNc and LC, the volume of SNc, the SNc/midbrain volume ratio as well as the visual scores of SNc and LC in iRBD patients were significantly decreased than those in controls (all P < 0.05). For quantitative analysis, the LC CNR acquired the highest accuracy in predicting iRBD (AUC 0.95, sensitivity 80%, specificity 100%), followed by SNc volume (AUC 0.93, sensitivity 88%, specificity 96%) and SNc CNR (AUC 0.74, sensitivity 92%, specificity 44%). For visual analysis, the accuracy of the visual score for SNc and LC were 78% (sensitivity 68%, specificity 88%) and 86% (sensitivity 88%, specificity 84%), respectively. The NM in the SNc and LC regions were significantly reduced in iRBD patients. NM measures showed good capability in discriminating iRBD from controls, suggesting that NM-MRI may be a valuable screening tool for iRBD.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"72-81"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered degree centrality and functional connectivity in girls with central precocious puberty. 中枢性性早熟女孩的度中心性和功能连通性发生改变。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-02-01 Epub Date: 2024-11-27 DOI: 10.1007/s11682-024-00954-y

Zhaoxia Qin, Hang Qu, Wenlong Zou, Xiaoxia Du, Yuefeng Li, Wei Wang

{"title":"Altered degree centrality and functional connectivity in girls with central precocious puberty.","authors":"Zhaoxia Qin, Hang Qu, Wenlong Zou, Xiaoxia Du, Yuefeng Li, Wei Wang","doi":"10.1007/s11682-024-00954-y","DOIUrl":"10.1007/s11682-024-00954-y","url":null,"abstract":"Girls who suffer from central precocious puberty (CPP) are at risk of experiencing detrimental psychological and behavioural consequences, along with impaired brain development. However, the mechanism by which puberty hormones affect patients with CPP remains unclear. This study aimed to use degree centrality (DC) analysis to explore the impact of premature activation of the hypothalamic-pituitary-gonadal (HPG) axis on brain functional development in girls with CPP. In this cross-sectional study, thirty-four girls (mean ± SD, 7.89 ± 0.81 years) with CPP and 25 age-matched girls without CPP (mean ± SD, 7.58 ± 0.73 years) underwent resting-state functional magnetic resonance imaging. We used DC analysis to explore brain network properties in CPP girls compared to non-CPP girls. Seed-based FC analysis was performed to identify the connections responsible for the observed differences. Our findings showed that female CPP patients had increased DC in the posterior lobe of the cerebellum and prefrontal areas and increased functional connectivity (FC) between the posterior lobe of the cerebellum and default mode network (DMN) regions relative to age-matched non-CPP girls. Additionally, compared with non-CPP patients, female CPP patients exhibited decreased DC in the bilateral superior parietal gyri and left superior occipital gyrus and reduced FC between the left superior occipital gyrus and right calcarine. A negative correlation was found between basal follicle-stimulating hormone level and DC of the bilateral superior parietal gyri in girls with CPP. The current research provides evidence that premature activation of the HPG axis is associated with the development of cortical function, particularly involving the posterior lobe of the cerebellum, DMN, and prefrontal, parietal, and occipital cortices. Our findings suggest that girls with CPP require attention and early treatment for cognitive and emotional problems as well as brain development in clinical practice.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"138-147"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142726066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The altered resting-state functional connectivity of thalamic subregions in patients with globus pharyngeus. 咽球患者丘脑亚区静息态功能连接的改变

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-02-01 Epub Date: 2024-10-17 DOI: 10.1007/s11682-024-00940-4

Yuanyuan Hu, Jingjie Zhao, Yuening Jin, Yi Du, Qian Zhao, Shuai Xu, Li Li, Yuan Zhou

{"title":"The altered resting-state functional connectivity of thalamic subregions in patients with globus pharyngeus.","authors":"Yuanyuan Hu, Jingjie Zhao, Yuening Jin, Yi Du, Qian Zhao, Shuai Xu, Li Li, Yuan Zhou","doi":"10.1007/s11682-024-00940-4","DOIUrl":"10.1007/s11682-024-00940-4","url":null,"abstract":"Globus Pharyngeus (GP) is a somatic symptom that accompanies mood distress. Although the etiology of GP remains unclear, its specific symptom of a false lump sensation in the throat without physical obstruction raises the possibility of alterations in brain networks responsible for somatosensory and emotion processing in patients with GP. To address this possibility, we investigated resting-state functional connectivity (rsFC) in 31 patients with GP and 24 healthy individuals using resting-state functional magnetic resonance imaging. Considering its significance in somatosensory and emotional functions, we focused on rsFC in the subregions of the thalamus. We found significantly decreased rsFC between the right caudal temporal thalamus (rcTtha) and the midcingulate cortex (MCC) as well as significantly decreased rsFC between the right rostral temporal thalamus (rrTtha) and the left cerebellum in the patients with GP. Additionally, within the patient group, the abnormalities in rsFC between the rcTtha and the MCC were correlated with the severity of somatization symptoms but not with depression and anxiety. These findings suggest alterations in the rsFC of thalamic subregions in patients with GP, shedding light on the pathogenesis of GP and potentially leading to improved diagnosis and treatment approaches for the condition.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"23-31"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microstructural correlates of olfactory dysfunction in Parkinson's Disease: a systematic review of diffusion MRI studies. 帕金森病嗅觉功能障碍的微观结构相关性：弥散核磁共振成像研究的系统回顾。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-02-01 Epub Date: 2024-10-10 DOI: 10.1007/s11682-024-00934-2

Homa Seyedmirzaei, Pegah Rasoulian, Mohammadamin Parsaei, Majid Hamidi, Amin Ghanbari, Alireza Soltani Khaboushan, Farzad Fatehi, Arash Kamali, Houman Sotoudeh

{"title":"Microstructural correlates of olfactory dysfunction in Parkinson's Disease: a systematic review of diffusion MRI studies.","authors":"Homa Seyedmirzaei, Pegah Rasoulian, Mohammadamin Parsaei, Majid Hamidi, Amin Ghanbari, Alireza Soltani Khaboushan, Farzad Fatehi, Arash Kamali, Houman Sotoudeh","doi":"10.1007/s11682-024-00934-2","DOIUrl":"10.1007/s11682-024-00934-2","url":null,"abstract":"Olfactory dysfunction (OD) is a non-motor symptom of Parkinson's Disease, affecting 75-95% of the patients. This symptom usually emerges before the clinical diagnosis, and patients with OD present with more severe forms of PD and need higher doses of therapy. It remains unknown whether OD is just a mere non-motor symptom or if it is a part of a series of pathological changes in different brain regions of the affected patients. We performed a systematic review to find the microstructural correlates of OD in people with PD. The systematic search in PubMed, Scopus, Embase, and Web of Science yielded ten eligible studies. Assessments in most included studies were inconclusive. However, we found variable brain regions and tracts associated with OD. The most repeated areas included the primary olfactory cortex, gyrus rectus, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, corticospinal tract, uncinate fasciculus, cingulum, and cerebellar peduncle. Despite some limitations, we pointed out the microstructural correlates of OD, which were also present in areas other than the olfactory system. These findings imply that OD might be a manifestation of an unknown, greater pathology in the brain of patients with PD.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"240-252"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of resting-state brain activity between insomnia and generalized anxiety disorder: A coordinate-based meta-analysis. 失眠症与广泛性焦虑症静息状态大脑活动的比较：基于坐标的荟萃分析。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-02-01 Epub Date: 2024-10-10 DOI: 10.1007/s11682-024-00949-9

Tongfei Jiang, Xuejiao Yin, Liying Zhu, Guiling Wang, Fan Zhang, Jing Guo

{"title":"Comparison of resting-state brain activity between insomnia and generalized anxiety disorder: A coordinate-based meta-analysis.","authors":"Tongfei Jiang, Xuejiao Yin, Liying Zhu, Guiling Wang, Fan Zhang, Jing Guo","doi":"10.1007/s11682-024-00949-9","DOIUrl":"10.1007/s11682-024-00949-9","url":null,"abstract":"Patients with insomnia disorder (ID) usually experience a greater burden of comorbid anxiety symptoms. However, the neural mechanism under the mutual relationship between ID and anxiety remains largely unclear. The meta-analysis aimed to explore the concordance and distinction of regional brain functional activity in patients with ID and those with generalized anxiety disorder (GAD) using coordinate-based activation likelihood estimation approach. Studies using resting-state regional homogeneity, amplitude of low-frequency fluctuations (ALFF), or fractional ALFF in patients with ID or GAD were included by searching multiple databases up to May 24, 2024. Using meta-analytic approach, 21 studies of ID vs. healthy controls (HC) and 16 studies of GAD vs. HC were included to illuminate the common and distinct patterns between the two disorders. Results showed that ID and GAD shared increased brain activities in the left posterior cingulate cortex and left precuneus, as well as decreased brain activity in the left medial prefrontal cortex. Additionally, compared with ID, GAD showed greater increased activities in the left superior frontal gyrus. Our study reveals both common and different activation patterns between ID and GAD, which may provide novel insights for understanding the neural basis of the two disorders and enlighten the possibility of the development of more targeted treatment strategies for ID and GAD.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"218-239"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0