Brain Imaging and Behavior最新文献_第8页

The Association of Upper Airway Anatomy with Brain Structure: The Multi-Ethnic Study of Atherosclerosis. 上气道解剖与大脑结构的关系：多种族动脉粥样硬化研究

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-06-01 Epub Date: 2024-01-09 DOI: 10.1007/s11682-023-00843-w

Robin M Nance, Alison E Fohner, Robyn L McClelland, Susan Redline, R Nick Bryan, Lisa Desiderio, Mohamad Habes, W T Longstreth, Richard J Schwab, Andrew S Wiemken, Susan R Heckbert

{"title":"The Association of Upper Airway Anatomy with Brain Structure: The Multi-Ethnic Study of Atherosclerosis.","authors":"Robin M Nance, Alison E Fohner, Robyn L McClelland, Susan Redline, R Nick Bryan, Lisa Desiderio, Mohamad Habes, W T Longstreth, Richard J Schwab, Andrew S Wiemken, Susan R Heckbert","doi":"10.1007/s11682-023-00843-w","DOIUrl":"10.1007/s11682-023-00843-w","url":null,"abstract":"Sleep apnea, affecting an estimated 1 in 4 American adults, has been reported to be associated with both brain structural abnormality and impaired cognitive function. Obstructive sleep apnea is known to be affected by upper airway anatomy. To better understand the contribution of upper airway anatomy to pathways linking sleep apnea with impaired cognitive function, we investigated the association of upper airway anatomy with structural brain abnormalities. Based in the Multi-Ethnic Study of Atherosclerosis, a longitudinal cohort study of community-dwelling adults, a comprehensive sleep study and an MRI of the upper airway and brain were performed on 578 participants. Machine learning models were used to select from 74 upper airway measures those measures most associated with selected regional brain volumes and white matter hyperintensity volume. Linear regression assessed associations between the selected upper airway measures, sleep measures, and brain structure. Maxillary divergence was positively associated with hippocampus volume, and mandible length was negatively associated with total white and gray matter volume. Both coefficients were small (coefficients per standard deviation 0.063 mL, p = 0.04, and - 7.0 mL, p < 0.001 respectively), and not affected by adjustment for sleep study measures. Self-reported snoring >2 times per week was associated with larger hippocampus volume (coefficient 0.164 mL, p = 0.007), and higher percentage of time in the N3 sleep stage was associated with larger total white and gray matter volume (4.8 mL, p = 0.004). Despite associations of two upper airway anatomy measures with brain volume, the evidence did not suggest that these upper airway and brain structure associations were acting primarily through the pathway of sleep disturbance.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139401860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct resting-state functional connectivity of the anterior cingulate cortex subregions in first-episode schizophrenia. 首发精神分裂症患者前扣带回皮层亚区不同的静息态功能连接。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-06-01 Epub Date: 2024-02-13 DOI: 10.1007/s11682-024-00863-0

Huan Huang, Cheng Chen, Bei Rong, Yuan Zhou, Wei Yuan, Yunlong Peng, Zhongchun Liu, Gaohua Wang, Huiling Wang

{"title":"Distinct resting-state functional connectivity of the anterior cingulate cortex subregions in first-episode schizophrenia.","authors":"Huan Huang, Cheng Chen, Bei Rong, Yuan Zhou, Wei Yuan, Yunlong Peng, Zhongchun Liu, Gaohua Wang, Huiling Wang","doi":"10.1007/s11682-024-00863-0","DOIUrl":"10.1007/s11682-024-00863-0","url":null,"abstract":"The anterior cingulate cortex (ACC) is a heterogeneous region of the brain's limbic system that regulates cognitive and emotional processing, and is frequently implicated in schizophrenia. This study aims to characterize resting-state functional connectivity (rsFC) profiles of three subregions of ACC in patients with first-episode schizophrenia and healthy controls. Resting-state functional magnetic resonance imaging (rs-fMRI) scans were collected from 60 first-episode schizophrenia (FES) patients and 60 healthy controls (HC), and the subgenual ACC (sgACC), pregenual ACC (pgACC), and dorsal ACC (dACC) were selected as seed regions from the newest automated anatomical labeling atlas 3 (AAL3). Seed-based rsFC maps for each ACC subregion were generated and compared between the two groups. The results revealed that compared to the HC group, the FES group showed higher rsFC between the pgACC and bilateral lateral orbitofrontal cortex (lOFC), and lower rsFC between the dACC and right posterior OFC (pOFC), the medial prefrontal gyrus (MPFC), and the precuneus cortex (PCu). These findings point to a selective functional dysconnectivity of pgACC and dACC in schizophrenia and provide more accurate information about the functional role of the ACC in this disorder.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attentional impairment and altered brain activity in healthcare workers after mild COVID-19. 轻度 COVID-19 后医护人员的注意力受损和大脑活动改变。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-06-01 Epub Date: 2024-02-01 DOI: 10.1007/s11682-024-00851-4

Keyi Lin, Yaotian Gao, Wei Ji, Yan Li, Wei Wang, Mengcheng Du, Jia Liu, Zhengyu Hong, Tao Jiang, Yuyang Wang

{"title":"Attentional impairment and altered brain activity in healthcare workers after mild COVID-19.","authors":"Keyi Lin, Yaotian Gao, Wei Ji, Yan Li, Wei Wang, Mengcheng Du, Jia Liu, Zhengyu Hong, Tao Jiang, Yuyang Wang","doi":"10.1007/s11682-024-00851-4","DOIUrl":"10.1007/s11682-024-00851-4","url":null,"abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is highly transmissible and pathogenic. Patients with mild cases account for the majority of those infected with coronavirus disease 2019 (COVID-19). Although there is evidence that many patients with COVID-19 have varying degrees of attentional impairment, little is known about how SARS-COV-2 affects attentional function. This study included a high-risk healthcare population divided into groups of healthcare workers (HCWs) with mild COVID-19 (patient group, n = 45) and matched healthy HCWs controls (HC group, n = 42), who completed general neuropsychological background tests and Attention Network Test (ANT), and underwent resting-state functional magnetic resonance imaging (rs-fMRI) using amplitude of low-frequency fluctuation (ALFF) to assess altered brain activity; Selective impairment occurred in orienting and executive control networks, but not in alert network, in the patient group, and widespread cognitive impairment encompassing general attention, memory, and executive dysfunction. Moreover, the patient group had significantly lower ALFF values in the left superior and left middle frontal gyri than the HC group. SARS-COV-2 infection may have led to reduced brain activity in the left superior and left middle frontal gyri, thus impairing attentional orienting and executive control networks, which may explain the development of attentional deficits after COVID-19.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139650218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered spontaneous regional brain activity in ventromedial prefrontal cortex and visual area of expert table tennis athletes. 乒乓球高手腹外侧前额叶皮层和视觉区的自发区域脑活动改变

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-06-01 Epub Date: 2024-01-22 DOI: 10.1007/s11682-023-00841-y

Yapeng Qi, Mengqi Zhao, Zhurui Yan, Xize Jia, Yingying Wang

{"title":"Altered spontaneous regional brain activity in ventromedial prefrontal cortex and visual area of expert table tennis athletes.","authors":"Yapeng Qi, Mengqi Zhao, Zhurui Yan, Xize Jia, Yingying Wang","doi":"10.1007/s11682-023-00841-y","DOIUrl":"10.1007/s11682-023-00841-y","url":null,"abstract":"Sports training may lead to functional changes in the brain, and different types of sports, including table tennis, have different influences on these changes. However, the effects of long-term table tennis practice on brain function in expert athletes are largely undefined. Here, we investigated spontaneous regional brain activity characteristics of expert table tennis athletes by using resting-state functional magnetic resonance imaging to compare differences between 25 athletes and 33 age- and sex-matched non-athletes. We analyzed four metrics-amplitude of low-frequency fluctuation (ALFF), fractional ALFF, regional homogeneity, and degree centrality-because together they identify functional changes in the brain with greater sensitivity than a single indicator and may more comprehensively describe regional functional changes. Additional statistical analysis was conducted to assess whether any correlation existed between brain activity and years of table tennis training for athletes. Results show that compared with non-athletes, table tennis athletes showed altered spontaneous regional brain activity in the ventromedial prefrontal cortex and the calcarine sulcus, a visual area. Furthermore, the functional changes in the calcarine sulcus showed a significant correlation with the number of years of expert sports training. Despite the relatively small sample size, these results indicated that the regional brain function of table tennis athletes was associated with sports training-related changes, providing insights for understanding the neural mechanisms underlying the expert performance of athletes.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139511817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spontaneous brain activity associated with individual differences in decisional and emotional forgiveness. 自发的大脑活动与决策和情感宽恕的个体差异有关。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-06-01 Epub Date: 2024-02-07 DOI: 10.1007/s11682-024-00856-z

Haijiang Li, Wenyuan Wang, Jingyu Li, Jiang Qiu, Yuedong Wu

{"title":"Spontaneous brain activity associated with individual differences in decisional and emotional forgiveness.","authors":"Haijiang Li, Wenyuan Wang, Jingyu Li, Jiang Qiu, Yuedong Wu","doi":"10.1007/s11682-024-00856-z","DOIUrl":"10.1007/s11682-024-00856-z","url":null,"abstract":"Previous studies have explored the neural bases of forgiveness, however, the neural associations of decisional and emotional forgiveness remain unclear. Regional homogeneity (ReHo) and functional connectivity (FC) measured by resting-state functional magnetic resonance imaging (fMRI) were used to investigate the neural associations of individual differences in decisional and emotional forgiveness among healthy volunteers (256 participants, 85 males). The results of the ReHo analysis showed that decisional forgiveness was positively correlated with the left inferior parietal lobule (IPL). Furthermore, emotional forgiveness was positively correlated with the dorsal anterior cingulate cortex (dACC) and left supramarginal gyrus (SMG). The results of the FC analysis showed that decisional forgiveness was positively associated with the FC strength between the left IPL and left middle frontal gyrus (MFG) and negatively correlated with the FC strength among the left IPL, right superior temporal gyrus (STG), and left SMG. Furthermore, there was a significant positive correlation between emotional forgiveness and FC strength between the left SMG and right IPL. These findings suggest an association between decisional and emotional forgiveness and spontaneous brain activity in brain regions related to empathy, emotion regulation, and cognitive control.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139696962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain network centrality and connectivity are associated with clinical subtypes and disease progression in Parkinson's disease. 大脑网络中心性和连通性与帕金森病的临床亚型和疾病进展有关。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-06-01 Epub Date: 2024-02-10 DOI: 10.1007/s11682-024-00862-1

Zhenzhen Chen, Chentao He, Piao Zhang, Xin Cai, Xiaohong Li, Wenlin Huang, Sifei Huang, Mengfei Cai, Lijuan Wang, Peiyan Zhan, Yuhu Zhang

{"title":"Brain network centrality and connectivity are associated with clinical subtypes and disease progression in Parkinson's disease.","authors":"Zhenzhen Chen, Chentao He, Piao Zhang, Xin Cai, Xiaohong Li, Wenlin Huang, Sifei Huang, Mengfei Cai, Lijuan Wang, Peiyan Zhan, Yuhu Zhang","doi":"10.1007/s11682-024-00862-1","DOIUrl":"10.1007/s11682-024-00862-1","url":null,"abstract":"To investigate brain network centrality and connectivity alterations in different Parkinson's disease (PD) clinical subtypes using resting-state functional magnetic resonance imaging (RS-fMRI), and to explore the correlation between baseline connectivity changes and the clinical progression. Ninety-two PD patients were enrolled at baseline, alongside 38 age- and sex-matched healthy controls. Of these, 85 PD patients underwent longitudinal assessments with a mean of 2.75 ± 0.59 years. Two-step cluster analysis integrating comprehensive motor and non-motor manifestations was performed to define PD subtypes. Degree centrality (DC) and secondary seed-based functional connectivity (FC) were applied to identify brain network centrality and connectivity changes among groups. Regression analysis was used to explore the correlation between baseline connectivity changes and clinical progression. Cluster analysis identified two main PD subtypes: mild PD and moderate PD. Two different subtypes within the mild PD were further identified: mild motor-predominant PD and mild-diffuse PD. Accordingly, the disrupted DC and seed-based FC in the left inferior frontal orbital gyrus and left superior occipital gyrus were severe in moderate PD. The DC and seed-based FC alterations in the right gyrus rectus and right postcentral gyrus were more severe in mild-diffuse PD than in mild motor-predominant PD. Moreover, disrupted DC were associated with clinical manifestations at baseline in patients with PD and predicted motor aspects progression over time. Our study suggested that brain network centrality and connectivity changes were different among PD subtypes. RS-fMRI holds promise to provide an objective assessment of subtype-related connectivity changes and predict disease progression in PD.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139711438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increasing variance of rich-club nodes distribution in early onset depression according to dynamic network. 根据动态网络，早期抑郁症患者富俱乐部节点分布的方差不断增大。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-06-01 Epub Date: 2024-02-13 DOI: 10.1007/s11682-023-00848-5

Naikeng Mai, Yujie Wu, Xiaomei Zhong, Ben Chen, Min Zhang, Qi Peng, Yuping Ning

{"title":"Increasing variance of rich-club nodes distribution in early onset depression according to dynamic network.","authors":"Naikeng Mai, Yujie Wu, Xiaomei Zhong, Ben Chen, Min Zhang, Qi Peng, Yuping Ning","doi":"10.1007/s11682-023-00848-5","DOIUrl":"10.1007/s11682-023-00848-5","url":null,"abstract":"Early onset depression (EOD) and late onset depression (LOD) are thought to have different pathogeneses, but lack of pathological evidence. In the current study we describe the dynamic rich-club properties of patients with EOD and LOD to address this question indirectly. We recruited 82 patients with late life depression (EOD 40, LOD 42) and 90 healthy controls. Memory, executive function and processing speed were measured, and resting-stage functional MRI was performed with all participants. We constructed a dynamic functional connectivity network and carried out rich-club and modularity analyses. Normalized mutual information (NMI) was applied to describe the variance in rich-club nodes distribution and partitioning. The NMI coefficient of rich club nodes distribution among the three groups was the lowest in the EOD patients (F = 4.298; P = 0.0151, FDR = 0.0231), which was positively correlated with rich-club connectivity (R = 0.886, P < 0.001) and negatively correlated with memory (R = -0.347, P = 0.038) in the EOD group. In the LOD patients, non-rich-club connectivity was positively correlated with memory (R = 0.353, P = 0.030 and R = 0.420, P = 0.009). Furthermore, local connectivity was positively correlated with processing speed in the LOD patients (R = 0.374, P = 0.021). The modular partition was different between the EOD patients and the HCs (P = 0.0013 < 0.05/3). The temporal instability of rich-club nodes was found in the EOD patients, but not the LOD patients, supporting the hypothesis that EOD and LOD result from different pathogenesis, and showing that the instability of the rich-club nodes across time might disrupt rich-club connectivity.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of childhood maltreatment and major depressive disorder on functional connectivity in hippocampal subregions. 童年虐待和重度抑郁障碍对海马亚区功能连接的影响

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-06-01 Epub Date: 2024-02-07 DOI: 10.1007/s11682-024-00859-w

Huiqin Nie, Tong Yu, Yurong Zou, Yuhong Li, Juran Chen, Jinrou Xia, Qianyi Luo, Hongjun Peng

{"title":"Effects of childhood maltreatment and major depressive disorder on functional connectivity in hippocampal subregions.","authors":"Huiqin Nie, Tong Yu, Yurong Zou, Yuhong Li, Juran Chen, Jinrou Xia, Qianyi Luo, Hongjun Peng","doi":"10.1007/s11682-024-00859-w","DOIUrl":"10.1007/s11682-024-00859-w","url":null,"abstract":"Major Depressive Disorder (MDD) with childhood maltreatment is a prevalent clinical phenotype. Prior studies have observed abnormal hippocampal activity in MDD patients, considering the hippocampus as a single nucleus. However, there is limited research investigating the static and dynamic changes in hippocampal subregion functional connectivity (FC) in MDD patients with childhood maltreatment. Therefore, we employed static and dynamic FC analyses using hippocampal subregions, including the anterior hippocampus and posterior hippocampus, as seed regions to investigate the neurobiological alterations associated with MDD resulting from childhood maltreatment. This study involved four groups: MDD with (n = 48) and without childhood maltreatment (n = 30), as well as healthy controls with (n = 57) and without (n = 46) childhood maltreatment. Compared to MDD patients without childhood maltreatment, those with childhood maltreatment exhibit altered FC between the hippocampal subregion and multiple brain regions, including the anterior cingulate gyrus, superior frontal gyrus, putamen, calcarine gyrus, superior temporal gyrus, angular gyrus, and supplementary motor area. Additionally, dynamic FC between the right medial-2 hippocampal head and the right calcarine gyrus shows a positive correlation with childhood maltreatment across all its subtypes. Moreover, dFC between the right hippocampal tail and the left angular gyrus moderates the relationship between childhood maltreatment and the depression severity. Our findings of distinct FC patterns within hippocampal subregions provide new clues for understanding the neurobiological basis of MDD with childhood maltreatment.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139696907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A short-interval longitudinal study of associations between psychological distress and hippocampal grey matter in early adolescence. 青少年早期心理困扰与海马灰质之间关系的短时纵向研究。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-06-01 Epub Date: 2024-01-13 DOI: 10.1007/s11682-023-00847-6

Amanda Boyes, Jacob M Levenstein, Larisa T McLoughlin, Christina Driver, Lia Mills, Jim Lagopoulos, Daniel F Hermens

{"title":"A short-interval longitudinal study of associations between psychological distress and hippocampal grey matter in early adolescence.","authors":"Amanda Boyes, Jacob M Levenstein, Larisa T McLoughlin, Christina Driver, Lia Mills, Jim Lagopoulos, Daniel F Hermens","doi":"10.1007/s11682-023-00847-6","DOIUrl":"10.1007/s11682-023-00847-6","url":null,"abstract":"This study of Australian adolescents (N = 88, 12-13-years-old) investigated the relationship between hippocampal grey matter volume (GMV) and self-reported psychological distress (K10) at four timepoints, across 12 months. Participants were divided into two groups; those who had K10 scores between 10 and 15 for all four timepoints were categorised as \"low distress\" (i.e., control group; n = 38), while participants who had K10 scores of 16 or higher at least once over the year were categorised as \"moderate-high distress\" (n = 50). Associations were tested by GEE fitting of GMV and K10 measures at the same time point, and in the preceding and subsequent timepoints. Analyses revealed smaller preceding left GMV and larger preceding right GMV were associated with higher subsequent K10 scores in the \"moderate-high distress\" group. This was not observed in the control group. In contrast, the control group showed significant co-occurring associations (i.e., at the same TP) between GMV and K10 scores. The \"moderate-high distress\" group experienced greater variability in distress. These results suggest that GMV development in early adolescence is differently associated with psychological distress for those who experience \"moderate-high distress\" at some point over the year, compared to controls. These findings offer a novel way to utilise short-interval, multiple time-point longitudinal data to explore changes in volume and experience of psychological distress in early adolescents. The results suggest hippocampal volume in early adolescence may be linked to fluctuations in psychological distress.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139431834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduced functional connectivity induced by longitudinal alterations of structure and perfusion may be associated with cognitive impairment in patients on maintenance hemodialysis. 结构和灌注的纵向改变所引起的功能连接性降低可能与维持性血液透析患者的认知障碍有关。

IF 3.2 3区医学

Brain Imaging and Behavior Pub Date : 2024-06-01 DOI: 10.1007/s11682-024-00897-4

Wenbo Yang, Mingan Li, Lijun Song, Boyan Xu, Qian Chen, Zhenghan Yang, Wenhu Liu, Aihua Zhang, Hao Wang, Zhen-Chang Wang

{"title":"Reduced functional connectivity induced by longitudinal alterations of structure and perfusion may be associated with cognitive impairment in patients on maintenance hemodialysis.","authors":"Wenbo Yang, Mingan Li, Lijun Song, Boyan Xu, Qian Chen, Zhenghan Yang, Wenhu Liu, Aihua Zhang, Hao Wang, Zhen-Chang Wang","doi":"10.1007/s11682-024-00897-4","DOIUrl":"https://doi.org/10.1007/s11682-024-00897-4","url":null,"abstract":"Hemodialysis (HD) leads to cognitive impairment; however, the pathophysiology of maintenance HD remains unclear. This study aimed to investigate the longitudinal alterations in gray matter volume (GMV) and cerebral blood flow (CBF) in patients on HD at follow-up compared with baseline, examine the alterations in functional connectivity (FC) by defining co-changed brain regions as seed points, and investigate the correlation between the co-changed brain regions and neuropsychological test scores. Twenty-seven patients with HD and 30 healthy controls were enrolled in this study. All participants underwent high-resolution T1-weighted imaging, arterial spin labeling, and functional MR imaging to measure GMV, CBF, and FC. The patients on HD were assessed at baseline and 3 years subsequently. The right and left medial superior frontal gyrus (SFGmed.L) exhibited significantly lower GMV and CBF in patients on HD at follow-up compared with baseline and lower FC between the SFGmed.L and left middle temporal gyrus (MTG.L). FC between the SFGmed.L and MTG.L was positively correlated with neuropsychological test scores in the HD group at follow-up. Reduced GMV and CBF may result in decreased FC between the SFGmed.L and MTG.L, which may be associated with cognitive impairment in patients on maintenance HD. Our findings provide unique insights into the pathological mechanisms of patients on maintenance HD with cognitive impairment.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141183436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0