BMC Musculoskeletal Disorders最新文献

{"title":"Melatonin administration attenuates fibrosis progression in frozen shoulder syndrome: a rat model study.","authors":"Serhat Gürbüz, Süleyman Semih Dedeoğlu, Ahmet Keskin, Mustafa Buğra Ayaz, Yunus Imren, Cem Comunoğlu, Bulent Karslıoğlu, Buse Aki","doi":"10.1186/s12891-025-09198-3","DOIUrl":"10.1186/s12891-025-09198-3","url":null,"abstract":"<p><strong>Background: </strong>Frozen shoulder syndrome, or adhesive capsulitis, is characterized by pain and restricted joint mobility due to fibrotic changes within the shoulder joint capsule. Despite its potential for spontaneous resolution, persistent symptoms often necessitate further treatment. Melatonin, known for its anti-inflammatory and anti-fibrotic properties, has emerged as a promising therapeutic agent for this condition. This study aimed to investigate the impact of melatonin on adhesive capsulitis in a rat model, focusing on its potential to attenuate fibrosis progression and improve joint pathology.</p><p><strong>Methods: </strong>Thirty female Sprague-Dawley rats were utilized in this study. Frozen shoulder syndrome was surgically induced, and the rats were divided into three groups: G1 receiving a melatonin antagonist, G2 receiving daily melatonin supplementation, and G3 without intervention. Histopathological evaluations were conducted at weeks 8 and 16 post-simulation to assess fibrosis, synovial hypertrophy, inflammatory cell infiltration, and hypervascularity. Statistical analyses were performed to determine significant differences between the groups.</p><p><strong>Results: </strong>Histological evaluations revealed that melatonin administration significantly attenuated fibrosis progression in the shoulder joint, particularly in the G2 (p < 0.05). No significant differences were observed in synovial hypertrophy, inflammatory cell infiltration, or hypervascularity between the groups (p > 0.05). Survival rates indicated no fatalities in the group receiving daily melatonin supplementation. Statistical analysis showed significant differences in fibrosis levels at 8 weeks between groups, with G1 exhibiting higher rate of severe fibrosis (p = 0.038). However, at 16 weeks, no significant differences were observed between groups (p > 0.05). Temporal changes within groups indicated a significant decrease in fibrosis levels and synovial hypertrophy from 8 to 16 weeks in G1 and G3 (p < 0.05). A comparison between operated and non-operated sides revealed significant differences in fibrosis levels in both groups at 8 and 16 weeks (p < 0.05).</p><p><strong>Conclusion: </strong>Melatonin administration demonstrated potential therapeutic benefits in attenuating fibrosis progression and reducing synovial hypertrophy in adhesive capsulitis.</p><p><strong>Level of evidence: </strong>NA, Animal Study.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"969"},"PeriodicalIF":2.4,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidisciplinary consensus on the management of patients with osteopenia and fracture risk in Spain.","authors":"Jose Luis Baquero Úbeda, Silvia García Díaz, Jesús-Carlos Gómez Martínez, Nina Martínez Fernández, Rafael Manuel Micó Pérez, Ingrid Möller, José Luis Neyro Bilbao, Pilar Saez López, Manuel Santiñà Vila, Josep Vergés Milano","doi":"10.1186/s12891-025-08997-y","DOIUrl":"10.1186/s12891-025-08997-y","url":null,"abstract":"<p><strong>Background: </strong>In Spain, over 3.5 million individuals are diagnosed with osteoporosis, while an even greater number are affected by osteopenia, the precursor stage of this severe condition. Unfortunately, osteoporosis and osteopenia frequently remain undetected until a fracture occurs, potentially resulting in permanent damage or even death.</p><p><strong>Methods: </strong>To improve the management of osteopenia, a multidisciplinary task force was established, consisting of 45 experts, including patients, doctors, nurses, pharmacists, and managers from 20 scientific organisations related to this pathology. With the scientific endorsement of the Spanish Society of Healthcare Quality (SECA) and using the Delphi qualitative research method. Although there was consistent agreement across the 75 variables analysed, a clear and consolidated consensus was reached on 56 of them (75%) after two rounds of consultation.</p><p><strong>Results: </strong>This agreement encompassed 13 variables related to general considerations, 10 of the 18 concerning diagnosis (55%), and 33 of the 44 regarding treatment (75%). Consistent agreement was reached on all issues consulted, strong consensus (≥ 80% agreement) was achieved for 50/57 variables (88%). Key recommendations highlight the importance of lifestyle modifications for people with osteopenia, including proper nutrition, fall prevention, regular physical exercise, weight control, smoking cessation, and alcohol consumption control.</p><p><strong>Conclusions: </strong>The study concludes that the current clinical management focuses excessively on the diagnosis of osteoporosis, neglecting previous stages of low bone mineral density, such as osteopenia, bone quality, and bone tissue structure. There is limited monitoring of risk factors such as previous fractures, despite their severe consequences. Therefore, a set of general recommendations related to diagnosis and treatment is proposed to improve the management of patients with this condition.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"970"},"PeriodicalIF":2.4,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of an alternative implant to suturing in ACL reconstruction: a biomechanical in vitro study.","authors":"Seyed Amir Hossein Sajedi, Amir Nourani, Solmaz Mojadam Mofrad, Mahmoud Chizari","doi":"10.1186/s12891-025-09152-3","DOIUrl":"10.1186/s12891-025-09152-3","url":null,"abstract":"","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"966"},"PeriodicalIF":2.4,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No clinical differences between outside-in and all-inside techniques in medial meniscus repair: emphasizing Minimal Clinically Important Difference (MCID) -based outcomes.","authors":"Aytek Hüseyin Çeliksöz, Ceyhun Çağlar, Serhat Akçaalan, Kenan Şen, Cevaydin Güler, Ali Okan Tarlacık, Ali Engin Daştan, Arman Vahabi","doi":"10.1186/s12891-025-09145-2","DOIUrl":"10.1186/s12891-025-09145-2","url":null,"abstract":"<p><strong>Background: </strong>While the all-inside (AI) technique is widely preferred for its simplicity and efficiency, the outside-in (OI) method is less commonly used. Despite both techniques being effective, direct comparisons of their functional outcomes are limited. This study aims to compare the clinical efficacy of OI and AI repair techniques for zone-3 and zone-4 medial meniscus tears, emphasizing outcomes based on the Minimal Clinically Important Difference (MCID).We hypothesized that there would be no significant difference in outcomes between the two techniques.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on 93 patients (mean age: 37.6 ± 11.8 years) with isolated zone-3 or zone-4 medial meniscus tears treated between 2020 and 2023. Patients were divided into two groups: OI (n = 63) and AI (n = 30), with all surgeries performed by two experienced orthopedic surgeons. Clinical outcomes were assessed using the International Knee Documentation Committee (IKDC) score, Knee Injury and Osteoarthritis Outcome Score (KOOS), and Tegner-Lysholm Knee Scoring Scale (TLKS) at a minimum follow-up of 6 months. The MCID was calculated using the 0.5 standard deviation method. Statistical analyses included ANCOVA to adjust for age-related differences, with significance set at p < 0.05.</p><p><strong>Results: </strong>Both OI and AI techniques resulted in significant improvements in IKDC, KOOS, and TLKS scores, surpassing MCID thresholds for all measures (p < 0.001). No significant differences were observed between the two groups in terms of functional outcomes (p > 0.05). The OI group utilized significantly fewer sutures (median: 1 [1-4] vs. 2 [1-7]; p < 0.001) and had a higher, though not statistically significant, complication rate (11% vs. 0%; p = 0.092). All complications were observed in the OI group, including saphenous nerve palsy and septic arthritis.</p><p><strong>Conclusion: </strong>Both outside-in and all-inside techniques offer comparable clinical improvements in the repair of zone-3 and zone-4 medial meniscus tears, achieving success defined by MCID thresholds. The outside-in group used fewer sutures and exhibited a slightly higher complication rate, although this difference was not statistically significant. These findings support similar clinical outcomes for both techniques and may help guide surgical decision-making based on individual cases and surgeon experience.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"962"},"PeriodicalIF":2.4,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-rater and inter-rater reliability of a new arthrometer for measuring anterior tibial translation in healthy subjects.","authors":"Junqiao Li, Jiayao Zhang, Weiting Li, Xiaolong Yang, Mingke You, Zeyu Liu, Wenjing Ma, Qi Li, Yan Xiong, Jian Li","doi":"10.1186/s12891-025-09209-3","DOIUrl":"10.1186/s12891-025-09209-3","url":null,"abstract":"<p><strong>Background: </strong>As a recently available arthrometer, the Ligs arthrometer has been gradually used in clinical practice to assess knee stability. However, its reliability has not been fully established in this regard. The aim of this study was to assess the intra-rater and inter-rater reliability of the Ligs arthrometer for measuring anterior tibial translation (ATT) and the corresponding side-to-side difference (SSD) in healthy subjects.</p><p><strong>Methods: </strong>A total of 40 healthy male subjects were recruited for this study between June 2023 and September 2023. Three examiners with different levels of experience tested the subjects with the Ligs arthrometer for ATT and SSD measurements. ATT values for both knees and the corresponding SSD at 90 N, 120 N, and 150 N were recorded for analysis. Statistical significance was determined using Student's t test or one-way analysis of variance (ANOVA). The intraclass correlation coefficient (ICC) was used to assess the intra-rater and inter-rater reliability of the Ligs arthrometer for ATT and SSD measurements.</p><p><strong>Results: </strong>No subject asked to stop any test due to pain or discomfort. There was no significant difference among the three examiners in ATT measurements of the subjects' ipsilateral knees and SSD measurements at the same load (P > 0.05 for all). Furthermore, ATT measurements for the subjects' left and right knees measured by the same examiner were comparable (P > 0.05 for all). The Ligs arthrometer showed excellent intra-rater reliability (ICCs = 0.930-0.982) for ATT measurements and moderate to good intra-rater reliability (ICCs = 0.705-0.862) for SSD measurements. Similarly, its inter-rater reliability was excellent (ICCs = 0.911-0.930) for ATT measurements, but moderate (ICCs = 0.684-0.737) for SSD measurements.</p><p><strong>Conclusion: </strong>The Ligs arthrometer had moderate to excellent intra-rater and inter-rater reliability for ATT and SSD measurements in healthy knees. As compared with ATT measurements, SSD measurements showed lower intra-rater and inter-rater reliability at the same load. It is recommended that the tests be performed by the same examiner when using the Ligs arthrometer for SSD measurements.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"960"},"PeriodicalIF":2.4,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiographic evaluation of key anatomical markers in discoid lateral meniscus: a systematic review and meta-analysis.","authors":"Xixin Jin, Xujin Wu, Yongtao Mao, Zelong Yang, Haoyu Wang","doi":"10.1186/s12891-025-09175-w","DOIUrl":"10.1186/s12891-025-09175-w","url":null,"abstract":"<p><strong>Purpose: </strong>The lateral discoid meniscus (DLM), a common anatomical variant in Asian populations, is often linked to knee pain, restricted motion, and an increased risk of meniscal tears. Due to limitations of magnetic resonance imaging (MRI) in certain patients, this study aims to assess the efficacy of X-ray parameters in diagnosing DLM, focusing on key features: lateral tibial spine height (LTSH), lateral joint space distance (LJSD), fibular head height (FHH), lateral tibial plateau obliquity (LTPO), and the condylar cut-off sign.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted using studies from PubMed, Embase, and Web of Science (January 2004 - October 2024). Studies with observational designs, X-ray measurements, and data on DLM were included. Mean difference (MD) and 95% CI analyses were performed using Review Manager and Stata.</p><p><strong>Results: </strong>Nine studies involving 788 discoid menisci and 761 normal knees were included. LJSD and FHH were significantly larger in the DLM group (MD = 1.18 and - 3.03, P < 0.01), while LTPO was smaller (MD = -2.18, P < 0.01). LTSH did not show significant differences in children but was smaller in adults with DLM (MD = -0.65, P < 0.01). The condylar cut-off sign also showed significant correlation in both adults and children (MD = -0.10, P < 0.01).</p><p><strong>Conclusion: </strong>This meta-analysis identifies LJSD, FHH, LTPO, and the condylar cut-off sign as key radiographic markers for diagnosing DLM, with accuracy enhanced when combined, particularly in the absence of MRI. LTSH appears diagnostically relevant mainly in adults, with limited value in pediatric populations.</p><p><strong>Level of evidence: </strong>IV.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"958"},"PeriodicalIF":2.4,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12523112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bipartite trapezium - rare congenital accessory bone: a case report of two bilateral cases among related patients and description of new accessory bone - os scaphocapitatum anterius.","authors":"Kunc Vojtěch, Veigl David, Dráč Pavel","doi":"10.1186/s12891-025-09166-x","DOIUrl":"10.1186/s12891-025-09166-x","url":null,"abstract":"<p><strong>Background: </strong>Trapezium typically maintains consistent morphology, and its anatomical variants are rare. We present the first known familial cases of multiple accessory carpal bones, including bipartite trapezium, and a previously undescribed volar accessory carpal bone located between the scaphoid and capitate.</p><p><strong>Case presentation: </strong>A 69-year-old woman was evaluated for a distal radius fracture. Further X-ray and CT imaging revealed a bilateral bipartite trapezium, bilateral os styloideum, os hamuli proprium all having smooth margins and regular cortico-medullar ratio. Cystic changes in the capitate, alongside abnormal morphology of the scaphoid and capitate were also present. Conservative treatment led to full recovery. Upon follow-up, the patient's daughter, reporting wrist clicking but no pain, underwent X-ray and CT imaging, which showed bilateral bipartite trapezium and a right os styloideum. Notably, a novel accessory bone was identified volarly between the scaphoid and capitate in the left wrist. Both cases were congenital and asymptomatic apart from mechanical clicking. None of the patients had associated anomalies.</p><p><strong>Conclusion: </strong>These cases represent the first familial report of a bipartite trapezium and introduce a previously unreported volar accessory carpal bone, for which we propose the term os scaphocapitatum anterius. Awareness of such variants is crucial for accurate radiological interpretation and appropriate surgical planning, particularly in cases of trauma or CMC joint pathology, when such variants might be confused with fracture. Advanced imaging modalities such as CT are recommended to confirm morphology and distinguish congenital variants from post-traumatic changes.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"964"},"PeriodicalIF":2.4,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12523150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anthropometric evaluation of trunk parameters in chronic low back pain: a comparative study with age- and sex-matched controls.","authors":"Martin Stribrny, Monika Svejdova, Andrew Busch, Jakub Novak, Tomas Kavka, Alena Kobesova","doi":"10.1186/s12891-025-09171-0","DOIUrl":"10.1186/s12891-025-09171-0","url":null,"abstract":"","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"959"},"PeriodicalIF":2.4,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of preoperative psychological state on postoperative outcomes of anterior cervical approach in cervical spondylotic myelopathy: a retrospective case‒control study.","authors":"Chunzeng Wang, Youdi Xue, Zhifa Lun, Ma Chao, Guangwang Liu, Xuan Yue, Zhaochuan Zhang","doi":"10.1186/s12891-025-09168-9","DOIUrl":"10.1186/s12891-025-09168-9","url":null,"abstract":"<p><strong>Objective: </strong>To explore the impact of the preoperative psychological state on postoperative clinical outcomes in patients with cervical spondylotic myelopathy(CSM) treated surgically by the anterior cervical approach.</p><p><strong>Methods: </strong>A retrospective study of 158 CSM patients undergoing anterior cervical surgery analyzed the impact of preoperative psychological state, measured by the preoperative mental state quality of life score (SF-12 MCS score). Patients were split into distress and non-distress groups for comparison. General data and clinical scores such as the Japanese Orthopaedic Association (JOA) score, neck disability index (NDI) score, visual analog scale (VAS) score, as well as patient satisfaction were assessed preoperatively and at final follow-up. Logistic analysis identified factors influencing psychological improvement in the distress group.</p><p><strong>Results: </strong>Among of 158 patients, 49 (31%) presented with preoperative psychological distress. This cohort experienced longer hospital stays and demonstrated poorer preoperative scores for NDI, physical health (PCS), and mental health (MCS). Both groups achieved significant and equivalent improvement in physical outcomes (JOA, VAS, NDI). Although the distress group showed greater improvement in MCS scores, their postoperative satisfaction rate (81.6%) was numerically lower than that of the non-distressed group (89.9%), a difference that was not statistically significant. A higher final mental health score was associated with a better preoperative MCS, a longer follow-up period, and male sex.</p><p><strong>Conclusions: </strong>Patients with CSM exhibit a high incidence of psychological distress. Anterior cervical surgery effectively improves both physical symptoms and mental health outcomes in these patients. Key factors associated with poorer mental health recovery include a low preoperative MCS score, shorter follow-up duration, and female sex. Importantly, preoperative psychological distress does not negatively affect the improvement in neurological function or overall postoperative satisfaction.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"955"},"PeriodicalIF":2.4,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and risk factors for poor prognosis in children with complicated acute hematogenous osteomyelitis treated with vaccum sealing drainage.","authors":"Jiale Guo, Wei Feng, Baojian Song, Danjiang Zhu, Yuwei Wen, Qiang Wang","doi":"10.1186/s12891-025-09094-w","DOIUrl":"10.1186/s12891-025-09094-w","url":null,"abstract":"<p><strong>Background: </strong>This study aims to analyze the clinical characteristics of children with complicated acute hematogenous osteomyelitis treated with vacuum sealing drainage (VSD) in our institution, and to explore the risk factors for poor prognosis.</p><p><strong>Methods: </strong>A retrospective analysis was performed on the medical records of patients diagnosed with acute hematogenous Osteomyelitis from December 2015 to December 2022. The demographic profiles, treatment procedures, examination results, and follow-up information of the patients were meticulously recorded. Patients were categorized into two groups based on the occurrence of treatment failure, deformity, limb length discrepancy, growth arrest, osteonecrosis, chronic osteomyelitis, pathological fracture, chondrolysis, and recurrence: good prognosis group and poor prognosis group. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors associated with adverse prognosis. The performance of the regression model was assessed using the area under the receiver operating characteristic (ROC) curve.</p><p><strong>Results: </strong>A total of 150 patients who met the inclusion criteria were followed up for an average of 3.4 years (range: 1.0-7.0 years). There were 31 patients (21%) in the poor prognosis group. In all cases, after 7 days of continuous saline irrigation and 2 surgical debridement, 75% of the infections were completely controlled, and the local abscess disappeared in 86% of the patients. By regression analysis, leukocyte admission (adjusted odds ratio (aOR) 1.2; 95% confidence interval (CI) [1.0-1.4]; P = 0.04), first postoperative C-reactive protein level (aOR 1.04; 95% (CI), [1.0-1.07], P = 0.034), time to diagnosis of osteomyelitis (aOR 1.3; 95% (CI), [1.1-1.6], P = 0.012), and days of fever with antibiotics (aOR 1.5; 95% (CI), [1.1-2.2], P = 0.024) were independent risk factors for poor outcomes. The four variables combined to construct an efficient prediction model, with an area under the curve (AUC) of 0.85.</p><p><strong>Conclusion: </strong>The innovative application of vacuum sealing drainage technology in the management of complicated patients with substantially localized abscesses achieved significant efficacy, while one-third of children still had unfavorable outcomes. High-risk groups with recurrence and sequelae necessitate regular follow-up and even long-term orthopedic intervention.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"963"},"PeriodicalIF":2.4,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}