BMC Musculoskeletal Disorders最新文献

{"title":"Magnesium versus titanium headless compression screws for fixation of a Hoffa-type fracture - a biomechanical in-vitro study.","authors":"Larissa Felten, Filippo Migliorini, Frank Hildebrand, Christian David Weber","doi":"10.1186/s12891-025-08559-2","DOIUrl":"10.1186/s12891-025-08559-2","url":null,"abstract":"<p><strong>Background: </strong>Intraarticular (e.g., Hoffa-type) fractures are usually stabilized with titanium screws, which may necessitate later implant removal. The aim of this study was to compare the biomechanical strength and stability of magnesium and titanium screws.</p><p><strong>Methods: </strong>18 double-layer bone blocks were fixed with 18 one-layer bone blocks and divided into 2 groups based on the fixation method: magnesium screw fixation (Magnesium group, n = 9) and traditional titanium screw (Titanium group, n = 9). Compressive force was applied to the specimens orthogonally to the screw axis. First, axial stiffness was measured, and a cyclic loading test was performed, after 10, 100, 1000 and 10,000 cycles respectively, and the axial displacements were recorded. Finally, the specimens were loaded to failure.</p><p><strong>Results: </strong>There were significant differences between the groups with respect to axial stiffness and cyclic loading. The ultimate failure load was comparable. The average axial stiffness for the magnesium group was 326 ± 67 N/mm and for the titanium group 266 ± 72 N/mm (p = 0.031). The axial displacement relative to 100 N preload after 10,000 cycles in the magnesium group was 1.7319 ± 0.2261 mm and in the titanium group 2.6932 ± 0.5921 mm (p < 0.001). The average ultimate failure in the magnesium group was 920 ± 55 N and in the titanium group 944 ± 40 N (p = 0.293).</p><p><strong>Conclusions: </strong>Based on the results magnesium screws show at least a comparable strength and stability as titanium screws in this setting. This study provides support from a biomechanical perspective for the use of magnesium screws in Hoffa fractures.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"321"},"PeriodicalIF":2.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the antimicrobial and anti-inflammatory mechanisms of dexmedetomidine in managing bone infection: a laboratory perspective.","authors":"Merve Hayriye Kocaoğlu, Günseli Çubukçuoğlu Deniz, Duru Aras-Tosun, Evrim Güneş Altuntaş, Erkan Tuncay","doi":"10.1186/s12891-025-08555-6","DOIUrl":"10.1186/s12891-025-08555-6","url":null,"abstract":"<p><strong>Background: </strong>Osteomyelitis involves bone destruction, impaired bone formation, and systemic inflammation. Dexmedetomidine (DXMT) possesses antioxidant, anti-inflammatory, and anti-apoptotic properties alongside sedative and analgesic effects. This study evaluates DXMT's effects on markers of infection and bone healing using osteocyte-like cells infected by Staphylococcus aureus (S. aureus).</p><p><strong>Methods: </strong>Human osteosarcoma-derived SAOS-2 cells were differentiated to an osteocyte-like phenotype over 28 days using potassium dihydrogen phosphate. Differentiation was verified via qPCR for osteogenic markers. Cytotoxicity of DXMT (0.1-10 µM) was tested using WST-1 assay and Reactive Oxygen Species (ROS) production analysis. Cells infected with S. aureus were treated with DXMT to assess its antimicrobial, anti-inflammatory (via ELISA for cytokines IL1-ß, TNF-⍺, IL-17, and IL-6), and osteogenesis-promoting effects.</p><p><strong>Results: </strong>DXMT ≤ 1 µM did not affect cell viability, while 2, 5, and 10 µM DXMT administration reduced cell counts. A 5 µM dose slightly reduced intracellular bacterial load (6.2 log in controls vs. 6.1 log with DXMT), while neither less nor more DXMT was effective on reducing the S. aureus load. Doses ≥ 5 µM effectively reduced ROS production and inflammation post-infection in a time-dependent manner. S. aureus infection decreased osteogenic markers, but DXMT mitigated cellular stress and inflammation with a positive impact on osteogenesis at therapeutic doses.</p><p><strong>Conclusion: </strong>DXMT at 5 µM is an optimal dose to reduce infection-induced cellular stress and promote bone healing in osteomyelitis in vitro, balancing antimicrobial effects and cytotoxicity.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"319"},"PeriodicalIF":2.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome and complication following single-staged posterior minimally invasive surgery in adult spinal deformity.","authors":"Chun Yeh, Pang-Hsuan Hsiao, Michael Jian-Wen Chen, Yuan-Shun Lo, Chun Tseng, Chia-Yu Lin, Ling-Yi Li, Chien-Ying Lai, Chien-Chun Chang, Hsien-Te Chen","doi":"10.1186/s12891-025-08550-x","DOIUrl":"10.1186/s12891-025-08550-x","url":null,"abstract":"<p><strong>Background: </strong>The aging population is experiencing a rising incidence of musculoskeletal problems and degenerative spinal deformities. Adult spinal deformity (ASD) presents challenges, with associated risks in open surgery. Minimally invasive surgery (MIS) is becoming increasingly popular due to its positive outcomes and potential benefits. This study aims to explore the clinical outcome and complications of posterior approach MIS in patients with ASD.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of patients with adult spinal deformity who underwent posterior minimally invasive surgery. 46 patients meeting the criteria were identified between June 2017 and September 2023. Comprehensive data were collected, including demographic details, surgical information, full-length radiographic measurements, and visual analog scale (VAS) pain scores. These data were obtained preoperatively, postoperatively, and at the final follow-up.</p><p><strong>Results: </strong>A total of 46 patients were included in the study, with a mean age of 68.58 years and a minimum follow-up period of 6 months. The mean operative time was 327 min, and the mean blood loss was 307 ml. Preoperative radiographic measurements were as follows: Coronal Cobb angle, 18.60 ± 11.35°; lumbar lordosis (LL), 22.79 ± 21.87°; pelvic incidence (PI), 53.05 ± 14.13°; PI-LL mismatch, 30.26 ± 23.48°; pelvic tilt (PT), 32.53 ± 10.38°; T1 pelvic angle (TPA), 31.91 ± 12.39°; and sagittal vertical axis (SVA), 77.77 ± 60.47 mm. At the final follow-up, coronal Cobb angle was 10.08 ± 6.47° (P <0.0001), LL was 26.16 ± 16.92° (P = 0.4293), PI was 54.17 ± 12.13° (P = 0.6965), PI-LL mismatch was 28.00 ± 17.03° (P = 0.6144), PT was 27.74 ± 10.24° (P = 0.0345), TPA was 25.10 ± 10.95 (P = 0.0090) and SVA was 47.91 ± 46.94 mm (P = 0.0129). Functional outcomes improved as well, with the mean Oswestry Disability Index (ODI) decreasing from 34.9 to 23.6 and the Visual Analog Scale (VAS) score for back pain reducing from 8.4 to 3.4. Surgical complications occurred in 39.1% of cases, with a low reoperation rate of 4.3%.</p><p><strong>Conclusion: </strong>Single-staged posterior MIS effectively corrects global alignment in adult spinal deformities, satisfying patient demand and yielding positive clinical outcome with low re-operation rate.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"318"},"PeriodicalIF":2.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing surgical rate of clavicle fractures and acromioclavicular dislocations in Chile: analysis over the last 15 years reveals disparities in access according to insurance type.","authors":"Catalina Vidal, Rodrigo de Marinis, Rodrigo Liendo, Isadora Silva, María Jesús Lira, Julio J Contreras","doi":"10.1186/s12891-024-07769-4","DOIUrl":"10.1186/s12891-024-07769-4","url":null,"abstract":"<p><strong>Background: </strong>In recent years, an increase in surgeries to treat clavicle injuries has been reported. It has been hypothesized that the studies regarding the beneficial effect of surgery in patients with displaced clavicle fractures may have contributed to raise the surgical rates for injuries around the clavicle. To our knowledge, there is a lack of data from Latin American countries on surgical rates of clavicle-related surgeries. The aim of this study is to describe the rate of clavicle surgeries, including clavicle fracture and acromioclavicular dislocation, in the last 15 years and to analyze the possible effect of sex, age, and health insurance in those rates.</p><p><strong>Methods: </strong>An observational cross-sectional study was carried out. Patients over 18 years old diagnosed with the following ICD-10 codes were selected: S420 \"Clavicle fracture\", S431 \"Dislocation of the acromioclavicular joint\", and S435 \"Sprains and strains of the acromioclavicular joint\". We collected information on the year of surgery, sex, age and type of insurance. The annual rate of surgeries and the rate for the period studied per 100,000 people were calculated. The rate was compared through negative binomial regression, reporting Incidence Rate Ratios (IRR) with 95% confidence interval (95% CI).</p><p><strong>Results: </strong>During a 15 years period of observation, 24,570 surgeries were performed. For clavicle fractures an 8.0 × 100,000 surgical rate was observed, and a 4.7 × 100,000 rate was found for acromioclavicular dislocations. The surgical rate for clavicular injuries increased from 2.8 in 2005 to 19.1 in 2019. Rates were higher in men, and ages between 20 and 35 years. The surgical rate for clavicular injuries in the public system was 11.1 × 100,000 and 30.9 × 100,000 in the private system, which represents a difference of 2.8 times between those healthcare systems.</p><p><strong>Conclusion: </strong>There has been a significant increase in clavicle and acromioclavicular dislocation surgeries in Chile, with disparities influenced by age, gender, and type of health insurance.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"316"},"PeriodicalIF":2.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthopedic surgical treatment of osteomalacia induced by culprit soft tissue tumor in the hip region: a single-center retrospective study.","authors":"Shuzhong Liu, Xi Zhou, Jinyi Xing, Annan Liang, Yong Liu, Weibo Xia","doi":"10.1186/s12891-025-08557-4","DOIUrl":"10.1186/s12891-025-08557-4","url":null,"abstract":"<p><strong>Background: </strong>Due to its occult position, complex anatomical structure, and spatial relationships, the causative tumor of Tumor-Induced Osteomalacia (TIO) in the hip region is quite difficult to detect and qualitatively diagnose in clinical practice. In this regard, clinicians often lack sufficient knowledge about such tumors, leading to frequent missed diagnoses, misdiagnoses, and unreasonable treatment.</p><p><strong>Objective: </strong>This study aimed to investigate the clinical characteristics of TIO patients with culprit soft tissue tumors in the hip region and evaluate the effect of surgical treatment on these individuals to improve clinicians' understanding of the rare phenomenon.</p><p><strong>Methods: </strong>The clinical data of all patients, from January 2013 to January 2023, who underwent surgical treatment for hip located culprit soft tissue tumors by the subspecialty group on bone and soft tissue tumors at our institution, were retrospectively analysed. Specifically, the clinical characteristics and therapeutic effects were examined and the patients' clinical experience was summarized.</p><p><strong>Results: </strong>Twenty-two patients, who met the inclusion criteria, were included. All patients experienced varying degrees of bone pain, commonly accompanied by weakness (16/22) and limited mobility (21/22), and 10 patients (45.5%) experienced a significant reduction in body height during the course of the disease. All patients underwent orthopedic surgery in the hip region, as hypophosphatemia occurred in all of them. Pathological diagnosis was confirmed to be consistent with causative tumors of TIO. All patients experienced a gradual increase in serum phosphorus postoperatively during short-term follow-up. The follow-up period was between 1 and 10 years, and the postoperative serum phosphorus levels were monitored at our hospital or other facilities close to the patients.</p><p><strong>Conclusions: </strong>Oncogenic soft tissue tumors for TIO in the hip region are occult, making clinical misdiagnoses or missed diagnoses highly likely. Therefore, enhancing the clinician's understanding of this rare condition is imperative. Notably, for TIO patient whose culprit tumor can be located, complete surgical resection of the causative tumor is the best treatment option. Furthermore, close postoperative monitoring of serum phosphorus is necessary, and patients should be subjected to long-term follow-up for prompt detection of recurrent conditions.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"324"},"PeriodicalIF":2.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of gas-containing lumbar disc cysts via a combination of posterior and extraforaminal approaches in arthroscopic-assisted uni-portal spine surgery: a case report and literature review.","authors":"Guijun Zhang, Lei Ren, En Song, Shengjun Shen","doi":"10.1186/s12891-025-08551-w","DOIUrl":"10.1186/s12891-025-08551-w","url":null,"abstract":"<p><strong>Background: </strong>Gas-containing lumbar disc cysts (LDCs) are a rare spinal pathology that frequently manifest as sciatica and exhibit clinical features akin to those observed in lumbar disc herniation. Their radiological presentation closely resembles that of synovial cysts, which can result in misdiagnosis, and their development is hypothesized to be associated with the 'vacuum phenomenon' observed in degenerative discs. Previous literature has documented various treatment modalities for disc cysts. In this report, we successfully excised the lesion using a combination of a posterior approach and an extraforaminal approach, facilitated by arthroscopy-assisted uniportal spinal surgery.</p><p><strong>Case presentation: </strong>An 85-year-old male patient developed persistent low back pain one month prior, accompanied by radiating discomfort in both lower extremities, predominantly on the right. Lumbar magnetic resonance imaging (MRI) and computed tomography (CT) scans revealed hypertrophy of the ligamentum flavum at the posterior margin of the L4/5 level, accompanied by spinal canal stenosis, and a gas-containing cyst on the right side extending into the extraforaminal region, which resulted in neural compression and functional impairment. The patient was treated using the AUSS technique. During the procedure, a unilateral posterior approach was initially employed to achieve unilateral laminotomy for bilateral decompression (ULBD) and excision of the intracanal cyst, followed by resection of the cysts in the foraminal and extraforaminal regions via an extraforaminal approach.</p><p><strong>Conclusion: </strong>Although gas-containing lumbar disc cysts are rare, the combined dual-approach AUSS technique has yielded favorable clinical outcomes. Postoperatively, the patient experienced marked improvement in lower limb pain and numbness; CT imaging confirmed complete cyst resection and adequate decompression of the dural sac and nerve roots.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"314"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social media as a source of information for patients with knee osteoarthritis.","authors":"Anas Dekhissi, Fatima Zahrae Taik, Fatima Zahra Aharrane, Anass Adnine, Nihad Takhrifa, Maryam Fourtassi, Fatima Ezzahra Abourazzak","doi":"10.1186/s12891-025-08552-9","DOIUrl":"10.1186/s12891-025-08552-9","url":null,"abstract":"<p><strong>Background: </strong>Knee osteoarthritis (KOA) is a chronic, disabling condition without a definitive cure, and current management strategies prioritize symptom relief and slowing disease progression rather than addressing the underlying cause. Therefore, KOA patients turn to social media (SM) in the hope of finding a solution or a treatment to relieve their pain. The main goal of this study was to explore the prevalence of information sought by KOA patients on SM and to determine factors associated with its use.</p><p><strong>Methods: </strong>This cross-sectional study included adult patients followed in our rheumatology department for KOA according to the American College of Rheumatology criteria for > 3 months. All patients underwent a standardized questionnaire-based interview covering their sociodemographic and clinical data, including age, level of education, body mass index, disease duration, and the presence of comorbidities. Pain intensity was measured using the Visual Analog Scale (VAS). We used the Lequesne index for KOA to assess functional impairment, and the Kellgren and Lawrence classification to assess the severity of KOA. We utilized the Trust in Physician Scale (TPS) to measure patients' trust in their physicians. In contrast, the Beliefs about Medicines Questionnaire (BMQ)-Specific Concerns subscale assessed patients' concerns about prescribed medication. Psychosocial risk factors were assessed using the Pain Catastrophizing Scale (PCS), the Generalized Anxiety Disorder (GAD-7), and the Patient Health Questionnaire for depression (PHQ-9).</p><p><strong>Results: </strong>A total of 178 patients were included, with an average age of 58 ± 9,915 years and a female predominance (88,2%). The average progression period of KOA was around 3 years [1; 8,5] and the median pain score on the VAS was 4,79 ± 2,214. A third of KOA patients turned to SM for health information, mainly YouTube. While 17% trusted the content, a comparable 10% shared it with their doctors. The main factors associated with SM use were younger age, higher level of education, and higher pain catastrophizing.</p><p><strong>Conclusion: </strong>These findings highlight the significant potential of SM platforms for KOA patients, whether it's enhancing their education and awareness, fostering peer support and community connections, or enabling better communication and remote monitoring with healthcare providers.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"315"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin use and risk of total joint replacement in patients with diabetes: a longitudinal cohort study of Alberta's Tomorrow Project.","authors":"Ming Ye, Jennifer E Vena, Grace Shen-Tu, Jeffrey A Johnson, Dean T Eurich","doi":"10.1186/s12891-025-08562-7","DOIUrl":"10.1186/s12891-025-08562-7","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize the association between metformin use and risk of total joint replacement in patients with diabetes using data from Alberta's Tomorrow Project (ATP), a population-based cohort study of chronic diseases in Alberta, Canada.</p><p><strong>Methods: </strong>The ATP participants with incidence of diabetes after enrollment were included and followed up to March 31, 2021. Metformin use, including daily doses, was measured by a time-varying approach during the follow-up. A multivariable Cox regression model was used to characterize the association between metformin use and risk of total joint replacement, after controlling for time-related variation in drug use, clinical status, BMI, lifestyles and concurrent medications.</p><p><strong>Results: </strong>Among 3,001 incident cases of diabetes (52% females, age at diagnosis 61.3 ± 9.5 years, average follow-up of 7.3 ± 4.7 years), the rate of total joint replacement was 7.57 per 1,000 person-year (PY) for metformin users and 9.31 per 1,000 PY for non-metformin users, with rate ratio = 0.81 (95% CI = 0.59-1.11, p-value = 0.09). In multivariable Cox regression analysis, metformin use was not significantly associated with risk of total joint replacement, with hazard ratio of 0.74 (95% CI = 0.52-1.03, p-value = 0.07) for patients with metformin medication, HR = 0.75 (95% CI = 0.46-1.22) for 0-1.0 g/day metformin use, and HR = 0.73 (95% CI = 0.49-1.08) for 1.0 + g/day use ('no metformin use' as the reference group).</p><p><strong>Conclusions: </strong>Although our findings are not statistically significant, our study suggests clinically a potential benefit of metformin use in reducing risk of total joint replacement in patients with diabetes.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"312"},"PeriodicalIF":2.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The neutrophil extracellular trap-related gene FPR1 (formyl peptide receptor 1) as a potential prognostic and therapeutic target in osteosarcoma.","authors":"Shihao Li, Qiong Yuan, Yuanyuan Zhang, Haiyang Zhang","doi":"10.1186/s12891-024-08231-1","DOIUrl":"10.1186/s12891-024-08231-1","url":null,"abstract":"<p><strong>Background: </strong>Neutrophil extracellular trap (NET) has been implicated in cancer progression and metastasis. Nevertheless, the role of the NET-related gene, formyl peptide receptor 1 (FPR1), in osteosarcoma (OS) remains largely unexplored. This study aimed to investigate the prognostic significance and biological function of FPR1 in OS.</p><p><strong>Methods: </strong>The least absolute shrinkage and selection operator (LASSO) algorithm was employed to construct a NET-related prognostic model utilizing OS datasets from TARGET and GEO (GSE21257) databases. The scRNA-seq dataset GSE162454 was then used for verifying the role of NET-related model in OS at single-cell resolution. Next, survival analysis and multivariate cox regression analysis were performed to evaluate the prognostic value of FPR1 in OS patients. The CIBERSORT algorithm was conducted to evaluate the relationship between FPR1 levels and immune cell abundance. Subsequently, the biological role of FPR1 was explored through CCK-8, and transwell assays in OS cell lines.</p><p><strong>Results: </strong>A signature NET score, comprising four NET-related genes (TNFRSF10C, FPR1, BST1 and SELPLG), was constructed to predict the prognosis of OS. The survival outcomes for patients in high-NET score group were markedly worse than that in the low-NET score group. Meanwhile, at single cell resolution, OS cells progressively evolved into tumors with elevated NET scores. Furthermore, FPR1 levels were markedly reduced in OS cells when compared to normal osteoblast cells, and the overexpression of FPR1 notably suppressed OS cell viability, migration and invasion. Additionally, OS patients exhibiting high levels of FPR1 demonstrated a favorable overall survival. Moreover, these patients also had a higher proportion of M1 macrophages and a lower proportion of M0 macrophages.</p><p><strong>Conclusion: </strong>Collectively, our study indicates that the NET-related gene FPR1 is closely related to tumor progression, prognosis and immune infiltration in OS.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"309"},"PeriodicalIF":2.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological readiness for return to sport following distal femoral osteotomy in patients with recurrent patellar instability.","authors":"Maximilian Hinz, Peter Rab, Moritz Brunner, Marco-Christopher Rupp, Armin Runer, Luca Grüning, Lisa Rahn, Sebastian Siebenlist, Andrea Achtnich","doi":"10.1186/s12891-025-08348-x","DOIUrl":"10.1186/s12891-025-08348-x","url":null,"abstract":"<p><strong>Background: </strong>There exists a paucity of data on the relationship between psychological factors and return to sport in patients who undergo surgery for complex patellofemoral instability (PFI). The purpose of this study was to investigate the influence of psychological factors on the return to the preoperative level of sports and knee function in patients with complex PFI who were treated with distal femoral osteotomy (DFO).</p><p><strong>Methods: </strong>Patients who underwent DFO for recurrent PFI associated with increased femoral antetorsion and/or valgus malalignment were included. Psychological readiness to resume sporting activities was assessed at a minimum of 12 months postoperatively using the PFI-Return to Sport after Injury (PFI-RSI) scale. A receiver operating curve (ROC) analysis was performed for the PFI-RSI scale and its ability to discriminate between patients who returned to the preoperative level of sport and those who did not. Spearman's rank-order correlation was used to test for correlations between the PFI-RSI scale and patient-reported outcome measures (PROM), including Banff Patella Instability Instrument 2.0 (BPII 2.0), Kujala score, Tegner Activity Scale (TAS) and Visual Analog Scale (VAS) for pain.</p><p><strong>Results: </strong>Sixty-five patients (70.8% female) were included at a median of 61.0 months (40.0-78.5 months) postoperatively. Patients who returned to their preoperative level of sports scored significantly higher on the PFI-RSI scale than patients who did not (75.8 [64.4-84.2] vs. 40.8 [23.4-60.9], p < 0.001). Reaching a threshold value of 55 on the PFI-RSI scale could predict whether or not patients returned to the preoperative level of sport with a sensitivity of 90.9% and a specificity of 70.6% (area under the curve = 0.834; Youden index = 0.615). The PFI-RSI scale showed moderate to strong correlations with PROM.</p><p><strong>Conclusion: </strong>Psychological readiness to resume sporting activities correlated with knee function and was significantly higher in patients who achieved the preoperative level of sport than in patients who did not.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"310"},"PeriodicalIF":2.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}