BMC Musculoskeletal Disorders最新文献

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Femoral inherent torsion is more accurate than femoral anteversion angle in evaluating femoral torsion to determine whether combine derotational distal femoral osteotomy or not.
IF 2.2 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-03-22 DOI: 10.1186/s12891-025-08522-1
Zhengyi Ni, Kehan Li, Xiaobo Chen, Yitong Hu, Jingting Zhang, Fei Wang
{"title":"Femoral inherent torsion is more accurate than femoral anteversion angle in evaluating femoral torsion to determine whether combine derotational distal femoral osteotomy or not.","authors":"Zhengyi Ni, Kehan Li, Xiaobo Chen, Yitong Hu, Jingting Zhang, Fei Wang","doi":"10.1186/s12891-025-08522-1","DOIUrl":"10.1186/s12891-025-08522-1","url":null,"abstract":"<p><strong>Background: </strong>Previous view is that femoral anteversion angle (FAA) is equivalent to femoral torsion (FT) and as an indication for derotational distal femoral osteotomy (DDFO) combined with medial patellofemoral ligament reconstruction (MPFLR), but posterior femoral condylar deformity affects FAA. Therefore, FAA is not accurate in assessing FT. Whether the femoral inherent torsion (FIT), which avoids the influence of the posterior condyle, can better reflect FT during surgery remains unknown. Meanwhile, the impact of the posterior femoral condyle on surgical outcomes remains unclear.</p><p><strong>Methods: </strong>Twenty-five patellar dislocation (PD) patients from 2017 to 2021 were conducted. All patients underwent both preoperative and postoperative computed tomography scans. Categorized by posterior condylar angle (PCA), they were divided into Group A (PCA ≤ 6.4°) and Group B (PCA > 6.4°). Radiographic measurements included FAA, femoral inherent torsion (FIT), patellar tilt angle, congruence angle and tibial tubercle-trochlear groove distance. For clinical outcomes, the Kujula score, Lysholm score, IKDC score to reflect the knee function. The Tegner activity score was used to assess the activity level. The VAS score was used to assess the pain control.</p><p><strong>Results: </strong>In both groups, the postoperative radiographic outcomes demonstrated a statistically significant improvement. Preoperatively, the FAA was similar in the two groups, but the FIT was greater in the Group A (21.7° ± 1.2° vs 18.4° ± 1 .3°, P < 0.001). However, there was no statistically significant difference between them in the postoperative period (7.4° ± 1.5° vs 7.1° ± 1.8°). In terms of clinical outcomes, both groups demonstrated a significant improvement in the postoperative period. However, the scores of the Group A significantly better (Kujula: 85.7 ± 5.0 vs 79.6 ± 4.8, P = 0.005; Lysholm: 86.8 ± 5.3 vs 80.2 ± 5.7, P = 0.006; IKDC: 86.1 ± 8.8 vs 75.5 ± 7.6, P = 0.004).</p><p><strong>Conclusion: </strong>FIT may be a more reliable indicator than FAA for evaluating FT in PD to determine whether combine DDFO or not, especially in the presence of posterior femoral condylar deformity. Posterior femoral condylar deformity appeared to result in a pseudo-increase in FAA. Simultaneous evaluation of FIT and FAA to identify true posterior condylar deformity offers the potential to prevent enlargement of DDFO and enable precision treatment.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"284"},"PeriodicalIF":2.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrent diffuse tenosynovial giant cell tumor of the posterior knee: a rare presentation with synovial herniation (Baker's cyst) in a young patient.
IF 2.2 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-03-22 DOI: 10.1186/s12891-025-08511-4
Khalid AlHarbi, Sultan AlHussain
{"title":"Recurrent diffuse tenosynovial giant cell tumor of the posterior knee: a rare presentation with synovial herniation (Baker's cyst) in a young patient.","authors":"Khalid AlHarbi, Sultan AlHussain","doi":"10.1186/s12891-025-08511-4","DOIUrl":"10.1186/s12891-025-08511-4","url":null,"abstract":"<p><strong>Introduction: </strong>Tenosynovial giant cell tumor (TGCT), previously referred to as pigmented villonodular synovitis (PVNS), is a rare, locally aggressive proliferative disorder of the synovium. It typically affects large joints, most commonly the knee. Posterior compartment involvement in the knee is less common compared to anterior or suprapatellar involvement, and it presents unique diagnostic and therapeutic challenges due to the complex anatomy and proximity to neurovascular structures. While popliteal (Baker's) cysts may coexist with intra-articular TGCT, they are considered synovial herniation cysts rather than true extra-articular involvement, which can be associated with diagnostic and therapeutic challenges.</p><p><strong>Case presentation: </strong>This case report describes a 24-year-old male with recurrent diffuse TGCT of the knee, predominantly involving the posterior compartment, along with a large Baker's cyst and synovial thickening adjacent to the medial femoral condyle. Magnetic resonance imaging (MRI) revealed extensive synovial proliferation with characteristic low T2 signal intensity, confirming the diagnosis and guiding surgical planning. The patient underwent arthroscopic-assisted synovectomy to address both the suprapatellar and posterior compartments while preserving critical neurovascular structures. Postoperatively, the patient had improved knee function and was referred for adjuvant therapy to minimize recurrence risk.</p><p><strong>Conclusion: </strong>This case highlights the importance of accurate imaging, meticulous surgical planning, and a multidisciplinary approach in managing rare presentations of TGCT. Long-term follow-up and consideration of adjuvant therapies such as radiotherapy or systemic therapies, including Pexidartinib, remain essential to minimize recurrence and optimize outcomes.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"281"},"PeriodicalIF":2.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioinformatics and machine learning approaches to explore key biomarkers in muscle aging linked to adipogenesis.
IF 2.2 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-03-22 DOI: 10.1186/s12891-025-08528-9
Yumin Zhang, Li Qin, Juan Liu
{"title":"Bioinformatics and machine learning approaches to explore key biomarkers in muscle aging linked to adipogenesis.","authors":"Yumin Zhang, Li Qin, Juan Liu","doi":"10.1186/s12891-025-08528-9","DOIUrl":"10.1186/s12891-025-08528-9","url":null,"abstract":"<p><p>Adipogenesis is intricately linked to the onset and progression of muscle aging; however, the relevant biomarkers remain unclear. This study sought to identify key genes associated with adipogenesis in the context of muscle aging. Firstly, gene expression profiles from biopsies of the vastus lateralis muscle in both young and elderly population were retrieved from the GEO database. After intersecting with the results of differential gene analysis, weighted gene co-expression network analysis, and sets of adipogenesis-related genes, 29 adipogenesis-related differential expressed genes (ARDEGs) were selected. Connectivity Map (cMAP) analysis identified tamsulosin, fraxidin, and alaproclate as key target compounds. In further, using three machine learning algorithms and the friends analysis, four hub ARDEGs, ESRRA, RXRG, GADD45A, and CEBPB were identified and verified in vivo aged mice muscles. Immune infiltration analysis showed a strong link between several immune cells and hub ARDEGs. In all, these findings suggested that ESRRA, RXRG, GADD45A, and CEBPB could serve as adipogenesis related biomarkers in muscle aging.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"285"},"PeriodicalIF":2.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arthroscopic Bankart repair using trans-glenoid double-loaded grand knots versus double-loaded suture anchors; is there a difference? a randomized controlled study. 关节镜下 Bankart 修复术中使用经蝶骨双加载大结节与双加载缝合锚是否有区别?
IF 2.2 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-03-21 DOI: 10.1186/s12891-025-08477-3
Amr Samir Rashwan, Al-Qassem Amin, Sherif Hamdy Zawam, Alaa Mohy-Eldin Soliman, Mahmoud El-Desouky
{"title":"Arthroscopic Bankart repair using trans-glenoid double-loaded grand knots versus double-loaded suture anchors; is there a difference? a randomized controlled study.","authors":"Amr Samir Rashwan, Al-Qassem Amin, Sherif Hamdy Zawam, Alaa Mohy-Eldin Soliman, Mahmoud El-Desouky","doi":"10.1186/s12891-025-08477-3","DOIUrl":"10.1186/s12891-025-08477-3","url":null,"abstract":"<p><strong>Background: </strong>Anatomical repair of Bankart lesions and restoring the tension of the antero-inferior capsulo-labral complex is the optimum method of surgical treatment with a variety of fixation methods including suture anchors and trans-glenoid sutures. Grand knot technique is a modification of the trans-glenoid sutures technique that can be an alternative to double-loaded suture anchors with a lower cost. We aimed to compare the outcomes and complications of both techniques.</p><p><strong>Methods: </strong>This is a randomized controlled study that was conducted on 200 patients with recurrent anterior glenohumeral dislocation, of whom 170 patients completed at least a three-year follow-up period. Arthroscopic Bankart repair using two double-loaded knotted suture anchors was performed in 78 cases (Group A) while repair was done using two trans-glenoid grand knots in other 92 cases (Group B). Patients were evaluated in terms of range of motion, functional scores (Constant, Rowe, and ASES), and complication rate.</p><p><strong>Results: </strong>The mean operative time was significantly longer in Group B (87.7 ± 24) minutes compared to Group A (61.2 ± 28.1) minutes (P = 0.002). No statistically significant difference was found between both groups regarding postoperative external rotation range of adducted arm, functional scores, and rate of recurrence. Only forward flexion and external rotation of abducted arm were significantly better in Group A (P = 0.005 and < 0.001 respectively).</p><p><strong>Conclusion: </strong>Trans-glenoid double-loaded grand knot technique is an alternative surgical option for the treatment of Bankart lesions with comparable results to double-loaded anchors regarding the functional outcomes and failure rates.</p><p><strong>Clinical trial registration (retrospectively registered): </strong>Registration number: NCT06394609 28-4-2024.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"280"},"PeriodicalIF":2.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the clinical efficacy of patellar lateral retraction and patellar eversion in total knee arthroplasty: a systematic review and meta-analysis.
IF 2.2 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-03-20 DOI: 10.1186/s12891-025-08532-z
Mingjie Dong, Xiaoyu Sun, Hao Fan, Weiping Ren, Yushan Wang, Yingjie Gao, Pengfei Shao, Yu Gao, Qiang Jiao, Yi Feng
{"title":"Comparison of the clinical efficacy of patellar lateral retraction and patellar eversion in total knee arthroplasty: a systematic review and meta-analysis.","authors":"Mingjie Dong, Xiaoyu Sun, Hao Fan, Weiping Ren, Yushan Wang, Yingjie Gao, Pengfei Shao, Yu Gao, Qiang Jiao, Yi Feng","doi":"10.1186/s12891-025-08532-z","DOIUrl":"10.1186/s12891-025-08532-z","url":null,"abstract":"<p><strong>Background: </strong>According to the mobilization technique of the intraoperative patella, total knee arthroplasty (TKA) can be categorized into patellar eversion (PE) and patellar lateral retraction (PLR). Comparisons between the two procedures are inconclusive; therefore, the study purpose was to assess the postoperative clinical efficacy to identify the most suitable procedure.</p><p><strong>Methods: </strong>Electronic databases were searched, including Web of Science, ScienceDirect, PubMed, Embase, OVID, the Cochrane Library, CINAHL, CNKI, and WANFANG, to identify clinical trials of PLR versus PE from inception to May 2023. The statistical software Stata 15.0 and Review Manager 5.4 were applied to the data analysis.</p><p><strong>Results: </strong>Fifteen studies evaluating a total of 1349 patients and 1409 knees were ultimately included. Statistically significant differences emerged between the PLR and PE groups with respect to blood loss (P = 0.02), incision length (P < 0.001), operation time (P = 0.01), straight leg raise (P < 0.001), knee range of motion (ROM; P < 0.05), the Knee Society Score (KSS) functional score (P = 0.0003), the visual analogue scale (VAS) score (1 and 3 months, both P < 0.05), and operative complications (P = 0.02). Furthermore, the PLR and PE groups had similar clinical efficacy in terms of quadriceps strength, VAS score (1 week and 1 year), Hospital for Special Surgery score, KSS pain score, Insall-Salvati ratio, and the occurrence of patella baja (all P ≥ 0.05).</p><p><strong>Conclusions: </strong>The PLR procedure is superior to PE in terms of blood loss, incision length, straight leg raise, knee ROM, VAS score (1 and 3 months), KSS functional score, and operative complications, although PE could decrease the operation time. PLR could achieve better postoperative clinical outcomes than could PE. Therefore, it is recommended that experienced surgeons prioritize PLR in TKA.</p><p><strong>Registration: </strong>This study was registered in the PROSPERO international registry (Registration ID: CRD42023440722).</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"279"},"PeriodicalIF":2.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The prevalence and surgical outcome of late diagnosed hip dysplasia in children with Prader-Willi syndrome: a retrospective study.
IF 2.2 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-03-20 DOI: 10.1186/s12891-025-08470-w
Yueqiang Mo, Chunxing Wu, Peng Huang, Dahui Wang, Yanhui Jing, Bo Ning
{"title":"The prevalence and surgical outcome of late diagnosed hip dysplasia in children with Prader-Willi syndrome: a retrospective study.","authors":"Yueqiang Mo, Chunxing Wu, Peng Huang, Dahui Wang, Yanhui Jing, Bo Ning","doi":"10.1186/s12891-025-08470-w","DOIUrl":"10.1186/s12891-025-08470-w","url":null,"abstract":"<p><strong>Background: </strong>Prader-Willi syndrome (PWS) is a rare disease. Hip dysplasia is an orthopedic-related disease of PWS. Limited literature exists on the prevalence, diagnosis, and surgical management of late diagnosed hip dysplasia in PWS. This study assessed the prevalence of hip dysplasia in children with PWS and evaluated the outcomes following surgical intervention of late diagnosed hip dysplasia.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on patients diagnosed with PWS at our institution from January 1, 2017 to December 31, 2021. Patient demographics were collected, the acetabular index (AI) and the central edge angle (CEA) were measured. A single fellowship-trained pediatric orthopedic surgeon determined the presence of hip dysplasia based on radiographic measurements.</p><p><strong>Results: </strong>The prevalence of hip dysplasia with PWS is 33.3%. There was no significant association between prevalence and sex or genetic subtype. The mean age at the time of diagnosis was 34.4 months (6 months to 109 months). Five patients (2 right side, 3 bilateral) underwent surgical intervention at an average age of 82.4 months. The acetabular index decreased from 42.8 ± 5.9 degrees preoperatively to 21.7 ± 7.7 degrees postoperatively. No serious postoperative complications were reported during the follow-up.</p><p><strong>Conclusions: </strong>The present study demonstrated a higher prevalence of hip dysplasia in patients with PWS than in the general population. The prevalence does not significantly differ across sexes or genetic subtypes. While preliminary findings suggest outcomes may be comparable to those of HD without PWS, further studies with larger cohorts are required to validate these observations.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"278"},"PeriodicalIF":2.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Muscle loading and endochondral ossification are involved in the regeneration of a fibrocartilaginous enthesis during tendon to bone healing in rabbits.
IF 2.2 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-03-19 DOI: 10.1186/s12891-025-08508-z
Xiaoke Shang, Can Chen, Jiefu Zhou, Yang Yang, Jin Qu
{"title":"Muscle loading and endochondral ossification are involved in the regeneration of a fibrocartilaginous enthesis during tendon to bone healing in rabbits.","authors":"Xiaoke Shang, Can Chen, Jiefu Zhou, Yang Yang, Jin Qu","doi":"10.1186/s12891-025-08508-z","DOIUrl":"10.1186/s12891-025-08508-z","url":null,"abstract":"<p><strong>Purpose: </strong>The purposes of the present study are to investigate the effects of reduced muscle loading by prolonged immobilization on the regeneration of fibrocartilaginous enthesis through endochondral ossification in rabbits.</p><p><strong>Methods: </strong>Forty-eight rabbits underwent standard partial patellectomy were randomly divided into the control group and the prolonged immobilization (PIM) group. The immobilized cast was only maintained for the first 4 weeks in the control group, while for the first 12 weeks or until euthanization in the PIM group. The Patella-patella tendon complexes were harvested for Micro-CT and histology at week 6, 12 and 18.</p><p><strong>Results: </strong>There was significantly lower bone volume in the PIM group than the control group at week 12, but not at week 6 and 18. At week 6, new bone was formed at the osteotomy site of the residual patella through endochondral ossification. At week 12, the chondrocytes in the tendon to bone interface were ordered and arranged in longitudinal rows separated by collagen fibres in the control group. While there were no visible fibers running continuously from tendon into bone in the PIM group. At week 18, a nearly normal fibrocartilaginous enthesis were regenerated in the control group. A similar fibrocartilaginous enthesis were also formed at the tendon to bone interface in the PIM group, but the four zones were not as distinct as that in the control group.</p><p><strong>Conclusion: </strong>Muscle loading and endochondral ossification are involved in the regeneration of a fibrocartilaginous enthesis during tendon to bone healing in this partial patellectomy model.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"277"},"PeriodicalIF":2.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepcidin knockout exacerbates hindlimb unloading-induced bone loss in mice through inhibiting osteoblastic differentiation.
IF 2.2 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-03-18 DOI: 10.1186/s12891-025-08515-0
Xin Chen, Jianping Wang, Chenxiao Zhen, Gejing Zhang, Zhouqi Yang, Youjia Xu, Peng Shang
{"title":"Hepcidin knockout exacerbates hindlimb unloading-induced bone loss in mice through inhibiting osteoblastic differentiation.","authors":"Xin Chen, Jianping Wang, Chenxiao Zhen, Gejing Zhang, Zhouqi Yang, Youjia Xu, Peng Shang","doi":"10.1186/s12891-025-08515-0","DOIUrl":"10.1186/s12891-025-08515-0","url":null,"abstract":"<p><strong>Background: </strong>An oligopeptide hepcidin is encoded by the human HAMP gene (Hamp in mice). Its deficiency can result in iron overload, while excess may lead to iron deficiency. Hepcidin knockout mice exhibited iron accumulation in multiple tissues, accompanied by degeneration of bone microarchitecture and reduced biomechanical properties. Astronauts who are exposed to weightlessness during prolonged spaceflight experience bone loss. After space missions, an interrelation exists between iron stores and bone mineral density (BMD). Bone loss in mice due to unloading is linked to iron excess and involves hepcidin. The potential role of hepcidin in unloading-induced bone loss remains unclear.</p><p><strong>Methods: </strong>Our study conducted relevant experiments using hepcidin knockout mice and their primary osteoblasts as the research subjects. We used the hindlimb unloading (HLU) model and the random positioning machine (RPM) system to simulate weightlessness in vivo and in vitro.</p><p><strong>Results: </strong>HLU mice exhibited reduced hepcidin levels in the serum and liver. Hepcidin knockout further diminished BMD and bone mineral content (BMC) in the femurs of HLU mice. Similarly, the bone volume fraction (BV/TV) and connectivity density (Conn.Dn) followed this downward trend, whereas trabecular separation (Tb.Sp) showed an inverse pattern. Moreover, hepcidin knockout decreased the ultimate load and elastic modulus in the tibias of HLU mice. Hepcidin knockout decreased PINP levels in the serum, a commonly used marker for bone formation, alongside elevated iron levels in the serum, liver, and bone of HLU mice. We also found higher serum MDA and SOD levels in these mice. In vitro, experimental data indicated that hepcidin knockout suppresses the osteoblastic differentiation capacity under RPM conditions. Additionally, this condition upregulates SOST protein levels and downregulates LRP6 and β-catenin protein levels in osteoblasts.</p><p><strong>Conclusion: </strong>Hepcidin knockout exacerbates bone loss in HLU mice, most likely due to reduced osteoblastic activity.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"276"},"PeriodicalIF":2.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11917043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the impact of movement representation techniques on recovery outcomes in post-orthopaedic surgery individuals: a systematic review and meta-analysis.
IF 2.2 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-03-18 DOI: 10.1186/s12891-025-08496-0
Xin Yu, Hu-Jun Wang, Xian-Feng Guo, Qian Pei, Xiao-Quan Wang, Wen-Qian Zhi, Jie Hao, Jing-Xuan Wang, Qiang Huang
{"title":"Evaluating the impact of movement representation techniques on recovery outcomes in post-orthopaedic surgery individuals: a systematic review and meta-analysis.","authors":"Xin Yu, Hu-Jun Wang, Xian-Feng Guo, Qian Pei, Xiao-Quan Wang, Wen-Qian Zhi, Jie Hao, Jing-Xuan Wang, Qiang Huang","doi":"10.1186/s12891-025-08496-0","DOIUrl":"10.1186/s12891-025-08496-0","url":null,"abstract":"<p><strong>Background: </strong>Although movement representation techniques has originally been used in neurological rehabilitation, growing researches suggests that it may also introduce advantageous effects to individuals with orthopaedic injuries. This systematic review and meta-analysis aimed to investigate the effects of these techniques on pain, range of motion, muscle strength, functional performance and fear of movement in individuals after orthopaedic surgeries.</p><p><strong>Method: </strong>Five electronic databases were searched until April 2024. Two reviewers independently conducted study selection and data extraction. Randomized controlled studies containing individuals after limb surgeries were identified. The quality of enrolled studies and the overall certainty of evidence was assessed by scales, respectively. Egger's test and funnel plot were used to assess publication bias. Subgroup analysis was also conducted to explore the source of heterogeneity.</p><p><strong>Results: </strong>Twenty-one randomized controlled trials involving 659 postsurgical participants were identified. The meta-analysis suggested moderate-quality evidence of a positive effect on pain intensity (SMD=-0.85; 95% CI -1.26, -0.43; p < 0.001). A low quality of evidence pointed toward a positive effect on functional scales (SMD=-0.84, 95% CI -1.27, -0.41, p < 0.001) and range of motion (SMD = 0.8, 95% CI 0.24, 1.35, p = 0.005). The very low quality of evidence suggested a significant effect on the functional test results (SMD=-0.8, 95% CI -1.01, -0.58, p < 0.001). The results remained nonsignificant for muscle strength and fear of movement. Intervention quantity, Disability of Arm, Shoulder, and Hand (DASH) score and intervention content were the sources of heterogeneity for pain intensity, functional scale score and range of motion, respectively.</p><p><strong>Conclusion: </strong>Compared with conventional rehabilitation, movement representation techniques increase pain relief, functional performance and range of motion. Our results support the use of mental practice techniques in individuals after orthopaedic surgeries, with moderate to very low-quality evidence.</p><p><strong>Review registration: </strong>This trial was registered on PROSPERO on 10 August, 2024 (CRD42024583380).</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"271"},"PeriodicalIF":2.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Stable elastic nail application with poller K-wire for Irreducible distal radius metaphyseal-diaphyseal Junction fractures in preadolescents: a new operative technique.
IF 2.2 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-03-18 DOI: 10.1186/s12891-025-08517-y
Levent Horoz, Mehmet Fevzi Cakmak, Cihan Kircil
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