BMC Musculoskeletal Disorders最新文献

{"title":"The impact of aging on achilles tendon ossification in mice.","authors":"Hanhua Cai, Yujian Lan, Huan Liu, Qi Hao","doi":"10.1186/s12891-025-08788-5","DOIUrl":"10.1186/s12891-025-08788-5","url":null,"abstract":"<p><strong>Background: </strong>Heterotopic ossification is a frequent complication of soft tissue injuries, particularly in tendons. Although ossification in tendon tissue has been reported in a range of aging and disease models, the underlying biomarkers and mechanisms remain unknown. And the characterisation and sensitivity of previous diagnostic biomarkers for tendon ectopic ossification do not meet the demands of clinical use. The aim of this study was to characterise the effects of aging on ossification in the mouse Achilles tendon and to identify characteristic genes and therapeutic targets for tendon ossification in mice by using a machine learning approach.</p><p><strong>Methods: </strong>We retrieved the transcriptome profile of GSE126118 from the Gene Expression Omnibus (GEO) database. Following background correction and normalization using the transcripts per million (TPM) method, differentially expressed genes (DEGs) were identified with the limma R package (p < 0.05, |log2FC| > 1). Subsequently, 468 senescence genes were downloaded from the Aging Atlas database, and senescence-associated DEGs (HO senescence genes) were identified. Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, and protein-protein interaction (PPI) network analyses were conducted on the identified DEGs. To further refine the HO aging signature, support vector machine (SVM) regression was employed. Additionally, we predicted transcription factors, miRNAs, and small molecule drugs potentially associated with the characterized genes.</p><p><strong>Results: </strong>Three characterised genes were identified as biomarkers associated with ectopic ossification and aging in the mouse Achilles tendon, Atp5o, Mmp2 and Mmp13. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses revealed significant enrichment in processes related to cartilage endochondral ossification, metalloendopeptidase activity, and mitochondrial proton transport ATP synthase complex. Additionally, HIF-1 and GnRH signaling pathways were prominently represented among the differentially expressed genes.</p><p><strong>Conclusion: </strong>Atp5o, Mmp2 and Mmp13 were identified as relevant signature genes for the effects of aging on Achilles tendon ossification in mice. Atp5o, Mmp2, and Mmp13 may influence tendon ossification by affecting mitochondrial function as well as extracellular matrix degradation to regulate senescence. This finding suggests a potential link between these processes, opening new avenues for research into diagnostic markers and therapeutic targets. These genes hold promise for the development of novel treatments for tendon ossification, a debilitating condition currently lacking effective therapeutic options.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"527"},"PeriodicalIF":2.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of metacarpal shortening on finger strength following non-surgical treatment of spiral and oblique metacarpal shaft fractures.","authors":"Martina Nöbel, Daniel Muder","doi":"10.1186/s12891-025-08776-9","DOIUrl":"10.1186/s12891-025-08776-9","url":null,"abstract":"<p><strong>Background: </strong>Treatment options for spiral/oblique metacarpal shaft fractures (MSFs) include both operative and non-operative approaches. Non-operative treatment with early mobilization has been shown to reduce treatment costs and sick leave, while maintaining grip strength despite metacarpal shortening. However, the impact of metacarpal shortening on strength at the metacarpophalangeal (MCP) or proximal interphalangeal (PIP) joints remains unclear. This study aimed to evaluate whether a shortening of more than 2 mm in spiral/oblique MSFs affects the strength of a single finger.</p><p><strong>Methods: </strong>A total of 23 patients with metacarpal shortening greater than 2 mm following a spiral/oblique MSF were included. The primary outcomes were flexion and extension strength in the MCP and PIP joints, compared to the uninjured hand. Secondary outcomes included range of motion, grip strength, metacarpal shortening, DASH score, patient satisfaction, pain levels, and return to work.</p><p><strong>Results: </strong>There were no differences observed in grip strength, range of motion, or MCP joint extension. However, PIP joint flexion and extension, as well as MCP joint flexion, were significantly reduced. The DASH scores were generally low (mean 4, range 0-23), with patients reporting no pain and high satisfaction.</p><p><strong>Conclusions: </strong>In conclusion, finger strength was statistically significantly reduced, but its clinical relevance remains unclear. Despite these findings, the low DASH scores and high patient satisfaction suggest that the functional impact of these changes may be minimal for most patients. We recommend discussing these findings with individuals who heavily rely on dexterity, such as professional musicians or other precision skill workers.</p><p><strong>Level of evidence: </strong>IV.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"525"},"PeriodicalIF":2.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic assessment of lower limb deformities using high-resolution X-ray images.","authors":"Reyhaneh Rostamian, Masoud Shariat Panahi, Morad Karimpour, Alireza Almasi Nokiani, Ramin Jafarzadeh Khaledi, Hadi Ghattan Kashani","doi":"10.1186/s12891-025-08784-9","DOIUrl":"10.1186/s12891-025-08784-9","url":null,"abstract":"<p><strong>Background: </strong>Planning an osteotomy or arthroplasty surgery on a lower limb requires prior classification/identification of its deformities. The detection of skeletal landmarks and the calculation of angles required to identify the deformities are traditionally done manually, with measurement accuracy relying considerably on the experience of the individual doing the measurements. We propose a novel, image pyramid-based approach to skeletal landmark detection.</p><p><strong>Methods: </strong>The proposed approach uses a Convolutional Neural Network (CNN) that receives the raw X-ray image as input and produces the coordinates of the landmarks. The landmark estimations are modified iteratively via the error feedback method to come closer to the target. Our clinically produced full-leg X-Rays dataset is made publically available and used to train and test the network. Angular quantities are calculated based on detected landmarks. Angles are then classified as lower than normal, normal or higher than normal according to predefined ranges for a normal condition.</p><p><strong>Results: </strong>The performance of our approach is evaluated at several levels: landmark coordinates accuracy, angles' measurement accuracy, and classification accuracy. The average absolute error (difference between automatically and manually determined coordinates) for landmarks was 0.79 ± 0.57 mm on test data, and the average absolute error (difference between automatically and manually calculated angles) for angles was 0.45 ± 0.42°.</p><p><strong>Conclusions: </strong>Results from multiple case studies involving high-resolution images show that the proposed approach outperforms previous deep learning-based approaches in terms of accuracy and computational cost. It also enables the automatic detection of the lower limb misalignments in full-leg x-ray images.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"521"},"PeriodicalIF":2.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential effect of Irisin on sarcopenia: a systematic review.","authors":"Yixiao Chen, Min Qian, Feng Gao, Guoqing Li, Kangzu Peng, Qingnan Sun, Yifei Sun, Gang Liu, Yufeng Ge, Minghui Yang, Xinbao Wu","doi":"10.1186/s12891-025-08767-w","DOIUrl":"10.1186/s12891-025-08767-w","url":null,"abstract":"<p><strong>Objective: </strong>Sarcopenia, a progressive musculoskeletal disorder associated with aging, is characterized by the deterioration of muscle mass, strength, and physical performance. This condition significantly increases the risk of debilitating consequences including functional impairment, diminished life quality, and increased mortality. With the progress of aging, it will affect a large number of people in the world and bring many problems. Despite its clinical significance, there are no medicine used to treatment sarcopenia by FDA approval in clinical. This systematic review synthesizes current evidence on the diagnostic and therapeutic potential of irisin-a myokine induced by exercise-in sarcopenia, aiming to address two key questions: (1) Can irisin serve as a reliable biomarker for sarcopenia diagnosis? (2) Does irisin hold promise as a therapeutic agent for sarcopenia management?</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across multiple databases (Web of Science, PubMed, Cochrane Library, and Embase) to examine the relationship between irisin and sarcopenia. Eligible studies meeting our inclusion criteria underwent rigorous quality assessment.</p><p><strong>Result: </strong>364 studies were identified, of which only 21 met the inclusion criteria-12 involving human studies and 9 involving animal and cell experiments. In human studies, irisin may serve as a potential diagnostic marker for sarcopenia in the elderly and postmenopausal women. In addition, as a myokine of exercise induced, increased circulating levels of irisin may enhanced skeletal muscle mass. Moreover, animal and cellular experiments suggest that increased levels of irisin help improve muscle mass.</p><p><strong>Conclusion: </strong>In conclusion, this review indicates that irisin has potential therapeutic effects for sarcopenia and may become a promising treatment for sarcopenia in the future. However, there is currently a lack of high-quality studies on the use of irisin in treating sarcopenia, and the relevant mechanisms of action are not yet clear. Therefore, more studies are needed to clarify the relationship between irisin and sarcopenia in the future.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"520"},"PeriodicalIF":2.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficiency of tactile discrimination training and oculomotor exercises in people with chronic neck pain: a randomized controlled trial.","authors":"Kübra Canlı, Gökhan Demirkıran, Filiz Can","doi":"10.1186/s12891-025-08755-0","DOIUrl":"10.1186/s12891-025-08755-0","url":null,"abstract":"<p><strong>Background: </strong>Tactile discrimination training (TDT) and oculomotor exercises (OEs) have been widely used somatosensory-based interventions for a wide range of chronic pain conditions. There is, however, little evidence for the effectiveness of these approaches in people with chronic neck pain. This study aimed to determine the superiority of one intervention over another on pain outcomes in people with chronic neck pain.</p><p><strong>Methods: </strong>Fifty seven participants were randomly divided into three groups: TDT, OEs, and a control group who received no intervention. TDT, OEs groups received either TDT or OEs, respectively, three times per week for four weeks. The control group received no intervention. Pain intensity, neck pain-related disability, pressure pain thresholds (PPTs), mechanical pain of temporal summation (mTSP), and conditioned pain modulation were assessed as pain outcomes. Depending on the normality, a repeated measures ANOVA or F1-LD-F1 design was used to analyse the data.</p><p><strong>Results: </strong>A significant group*time interaction and main effects for time were found for pain intensity (p: 0.001, p: 0.001, respectively) and pain-related disability (p < 0.019, p < 0.009; respectively). There was a significant main effect for time for mTSP at the painful side of the neck (p: 0.022). TDT and OEs resulted in a significantly higher improvement in pain intensity (p: 0.005, p < 0.001; respectively) and neck pain-related disability (p: 0.005, p: 0.007; respectively). There was a higher improvement in pain intensity in OEs group compared to TDT group (p: 0.010). A significantly higher improvement in PPT at the painful site after OEs was found (p: 0.038). The control group demonstrated a significantly higher improvement in mTSP in the painful area of the neck (p: 0.048). There were no other significant within- or between-group changes.</p><p><strong>Conclusion: </strong>OEs and TDT are effective somatosensory-based interventions for improving pain intensity and pain-related disability.</p><p><strong>Impact: </strong>This study demonstrated that sensory retraining interventions improves the subjective pain perception.</p><p><strong>Trial registration: </strong>Trial Registration Number: NCT05605132, Date of trial registration: 10/29/2022, Name of trial registry: Neck Pain.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"519"},"PeriodicalIF":2.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone filler and adhesive at the same time: in-vitro analysis in a porcine fracture model.","authors":"Stefanie Hoelscher-Doht, Nicola Zufall, Maximilian Heilig, Philipp Heilig, Martin Cornelius Jordan, Rainer Heribert Meffert, Uwe Gbureck, Lea Hüls","doi":"10.1186/s12891-025-08773-y","DOIUrl":"10.1186/s12891-025-08773-y","url":null,"abstract":"<p><strong>Background: </strong>Bone defects in the context of fracture treatment or tumor surgery represent a major challenge regarding their treatment. Sticky and drillable magnesium phosphate cements could revolutionize the intraoperative reconstruction of complex fractures close to the joint due to their properties as bone adhesive and filler at the same time, enabling the technique of first reduction of the fracture fragments by bonding with the cement and then applying stabilization with screws and/or plates.</p><p><strong>Methods: </strong>Lateral split-depression fractures of the proximal tibia were generated in 27 porcine specimens, which were then randomized into 3 groups of 9 each. In group A, a new operative technique was applied by reducing the fracture using a newly formulated magnesium phosphate cement (MgP cement) and then applying stabilization by plate osteosynthesis. In the other two groups, plate osteosynthesis was performed first, as in the current standard operative procedure, followed by the injection of a bone graft substitute through a gap in the fracture area of the tibia, group B with MgP cement, group C with hydroxyapatite cement. The following parameters were determined during the cyclic testing phase of 3000 test cycles: The total displacement and the optical displacement of the lateral plateau [mm]. During load-to-failure tests, the stiffness [N/mm], the maximum load [N] and the normalized maximum load [%] were determined.</p><p><strong>Results: </strong>The results revealed a comparable stability for all groups with no significant differences in all forms of displacement, with group A demonstrating the lowest values for displacement. Maximum load was highest for group C (group B; C [p = 0.04]; group A; C [p < 0.01]), however considering normalized maximum load, no significant difference between the three groups could be found.</p><p><strong>Conclusions: </strong>This study presents a breakthrough approach using a bone cement as both a bone adhesive and a filler at the same time. The adhesive and drillable magnesium phosphate cement proved to be a versatile solution featuring a new surgical method in which the fracture was anatomically reduced using only the cement. Furthermore, with this new technique, the cement demonstrated comparable, if not slightly superior, biomechanical stability in the porcine tibial split depression fracture model compared to the current standard of surgical treatment using primary plate osteosynthesis and a commercial hydroxyapatite cement.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"524"},"PeriodicalIF":2.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the presence of adjacent septic arthritis in children with acute hematogenous osteomyelitis.","authors":"Shuting Lin, Donghao Gu, Peng Ning, Jingyu Wu, Zhixin Yang, Tianjing Liu","doi":"10.1186/s12891-025-08671-3","DOIUrl":"10.1186/s12891-025-08671-3","url":null,"abstract":"<p><strong>Introduction: </strong>This study conducted statistical analysis of clinical data from cases of acute hematogenous osteomyelitis (AHO) with or without concomitant septic arthritis, with the objective of identifying factors that are indicative of concomitant septic arthritis. Predictive models will be developed to predict coexisting infections, with one that is independent of MR findings and another that incorporates MRI data.</p><p><strong>Methods: </strong>A retrospective review of 127 children (132 cases of AHO) treated for AHO was performed. All patients underwent MRI. The data encompassed various demographic, clinical, and diagnostic factors. Graphical and logistical regression analysis was used to determine variables independently predictive of adjacent infection. Optimal cutoff values were determined for each variable and a prediction model was created. Finally, the model was applied to our patient database and each patient with isolated AHO, or concomitant infection was stratified based upon the number of positive predictive factors.</p><p><strong>Results: </strong>The overall incidence of coexisting septic arthritis in patients with AHO was 52.2% (69/132). Four risk factors (age below 4 years, a history of preceding infection, platelet count > 390.5 × 10^9/L, and absolute neutrophil count < 5.45 × 10^3 cells/ml) were found to be predictive of concomitant infection and were included in the algorithm. Patients with ≥ 2 risk factors were classified as high risk for AHO with concomitant infection (Sensitivity: 79.41% (95% CI: [64.10%, 94.71%]), Specificity: 76.56% (95% CI: [58.61%, 94.51%]), Positive Predictive Value (PPV): 78.26% (95% CI: [63.43%, 93.09%]), and Negative Predictive Value (NPV): 77.78% (95% CI: [61.02%, 94.54%]). In MRI, joint effusion was the primary indicator of concomitant septic arthritis in patients with AHO, followed by the absence of subperiosteal abscess. The presence of subperiosteal abscess in the absence of joint effusion was highly correlated with isolated AHO, showing a 100% occurrence rate (39/39).</p><p><strong>Conclusions: </strong>Our study successfully identified several risk factors and radiologic signs associated with concomitant septic arthritis in patients with AHO. These findings can assist clinicians in early recognition and management of coexisting infections, especially in situations where MRI is not readily available or when its findings are inconclusive. Timely identification of these factors is crucial for appropriate treatment planning and improved patient outcomes.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"523"},"PeriodicalIF":2.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of osteoarthritis and clinical outcomes in patients with fractures of the tibial plateau - medium- and long-term analysis.","authors":"Jon Klasér, Lisa Kotake, Marcus Lindberg, Simon Wigge, Robert Lundqvist, Grzegorz Szczęsny, Przemysław T Paradowski","doi":"10.1186/s12891-025-08786-7","DOIUrl":"10.1186/s12891-025-08786-7","url":null,"abstract":"<p><strong>Background: </strong>The incidence of post-traumatic osteoarthritis (OA) following intraarticular knee fractures has been estimated to be relatively high but it varies substantially between different reports. In this study we sought to assess the prevalence of radiographic knee OA secondary to tibial plateau fractures (TPF). The second aim was to report medium- and long-term functional outcomes and investigate whether there were any risk factors associated with these outcomes.</p><p><strong>Methods: </strong>We retrospectively reviewed documentation of patients who had TPF between 2001 and 2015. The radiographs, clinical characteristics and patient-reported outcome measures (PROMs) scores were evaluated. Presence of radiographic OA was the primary endpoint. The other endpoints were the relationship between OA and different potential predictors as well as the scores in PROMs.</p><p><strong>Results: </strong>The study involved a total of 130 patients including 114 who were radiographically examined at mean follow-up time of 10 years (range 4.6-19.3 years). Radiographic OA was present in 50% of patients (34% in the injured knee and 16% in both knees). Having OA in the contralateral knee increased the odds to develop OA in the index knee (OR = 4.8; 95%CI 1.6-4.1 in the crude model and OR = 6.6; 95%CI 1.8-23.5 in the model adjusted for age, sex, BMI, fracture type and treatment method). The occurrence of OA was associated stronger with medial or bicondylar TPF than with lateral condyle TPF (OR = 2.8; 95%CI 1.2-6.1 in the crude model and OR = 3.4; 95%CI 1.4-8.6 in the adjusted model). The KOOS scores were significantly lower in patients with OA than in those without OA in the index knee in all the KOOS subscales (p < 0.007), except for the KOOS Symptoms (p = 0.362). The EQ-5D-5L index score was significantly higher in patients without OA in the index knee compared to those with OA (p = 0.015).</p><p><strong>Conclusion: </strong>Radiographic OA following TPF occurred in 50% of knee joints. The odds for knee OA were highest after medial or bicondylar fractures. Patients with OA in the index knee had lower scores in both condition-specific and generic PROMs than subjects without OA, which indicates that TPF may contribute to the development of both OA disease and illness.</p><p><strong>Trial registration: </strong>The trial was registered retrospectively on June 4, 2024 on ClinicalTrials.gov (registration number: NCT06451510).</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"522"},"PeriodicalIF":2.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and microbiological profile of spondylodiscitis: a retrospective analysis.","authors":"Ghazaleh Golchoub, Ida Hosseini, Amirali Alamdari, Shabboo Ansari, Farid Javandoust Gharehbagh, Mahboobeh Taheri, Ilad Alavi Darazam","doi":"10.1186/s12891-025-08748-z","DOIUrl":"10.1186/s12891-025-08748-z","url":null,"abstract":"<p><strong>Background: </strong>Spondylodiscitis is a rare infectious disease with rising incidence in recent years. From 2005 till 2021 the incidence of Spondylodiscitis rose by 104%. Given its potential to cause complications and mortality, it demands greater attention. Epidemiological data and predisposing factors can vary significantly across different geographical regions, suggesting that data from Iran may differ from those in other parts of the world. This study aims to evaluate the demographic, clinical, laboratory, and imaging characteristics of spondylodiscitis patients treated at Loghman Hakim Hospital in Tehran. Additionally, it seeks to analyze the treatment outcomes and complications associated with the disease.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 65 adult patients diagnosed with spondylodiscitis over the past decade (2012-2022). The data collected encompassed demographic characteristics, underlying diseases, clinical presentations, laboratory and radiological findings, microbiological results, treatment approaches, and outcomes.</p><p><strong>Results: </strong>The study included 65 adult patients with a mean age of 55.12 years, showing a slight male predominance (58.5%). Spondylodiscitis was community-acquired in 49.2% of cases and hospital-acquired postoperatively in 50.8%. The lumbosacral spine was the most affected region (47.4%). Staphylococcus aureus was the most frequently isolated microorganism (28.2%), followed by Mycobacterium tuberculosis. Complications included abscess formation in 49.2% of patients and multiorgan failure in 6.2%, resulting in death. Treatment primarily involved antibiotic therapy, with surgical intervention in select cases. Poor outcomes were observed in patients with unidentified microorganisms and those with longer delays in diagnosis.</p><p><strong>Conclusions: </strong>Spondylodiscitis is associated with significant morbidity and a high rate of complications, particularly in cases with delayed diagnosis. Early diagnosis, appropriate antimicrobial therapy, and surgical intervention when necessary are crucial for improving patient outcomes. This study highlights the need for ongoing research to optimize diagnostic pathways and develop long-term management strategies for spondylodiscitis.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"515"},"PeriodicalIF":2.2,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal parameters and Biomechanical analysis of the lightbulb technique for osteonecrosis of the femoral head: a finite element analysis.","authors":"Yuhu Zhou, Long Yang, Daizhu Yuan, Zhanyu Wu, Shunen Xu, Chuan Ye","doi":"10.1186/s12891-025-08763-0","DOIUrl":"10.1186/s12891-025-08763-0","url":null,"abstract":"<p><strong>Background: </strong>The lightbulb technique (LBT) is a common surgical procedure for treating peri-collapse osteonecrosis of the femoral head (ONFH). However, the drilling parameters and biomechanics of the technique have not been analyzed. The aim of this study was to optimize the biomechanical stability of the LBT by finite element (FE) analysis to guide intraoperative and postoperative schemes.</p><p><strong>Methods: </strong>FE models were established based on computed tomography images of a healthy adult, including three different degrees of necrotic lesion (60°, 100°, 115°), drilling locations (points C and L) and diameters (1.0 cm, 1.5 cm). The stress of the drilling entrance area, superior and inferior edges of the femoral neck, and bone flap was evaluated under three different loads at 0.5 times body weight (0.5 BW, standing on two feet), 2.75 BW (standing on one foot), and 4 BW (walking with the middle foot on the ground).</p><p><strong>Results: </strong>The stress of the superior and inferior edges of femoral neck, entrance, and bone flap increased as drilling diameter increased. The maximum Von Mises stress of proximal femur does not exceed its yield strength with diameter of 1.0 cm, except for diameter of 1.5 cm. The stress of entrance area and bone flap cortex at point L were higher than those at point C with same diameter. Moreover, the stress of femoral neck and entrance area decreased as the range of lesions increased, except for bone flap cortex. Furthermore, the maximum Von Mises stress of proximal femur did not exceed its yield strength with patients standing on one or both feet and walking process (4BW) with drilling diameter of 1.0 cm at points C or L after surgery, except for diameter of 1.5 cm. Meanwhile, the angles reaching to the coronal plane and transverse plane of weight-bearing area through point L with diameter of 1.0 cm were smaller than those through point C.</p><p><strong>Conclusions: </strong>The optimal parameters of LBT can be selected with a diameter of 1.0 cm at point L. Patients can load partial weight to stimulate the healing of the necrotic area after surgery, but avoid beyond middle foot weight during walking.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"516"},"PeriodicalIF":2.2,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}