BMC Musculoskeletal Disorders最新文献

筛选
英文 中文
Previous knee surgery increases risks of revision, infection, pain and stiffness after knee replacement arthroplasty: a systematic review and meta-analysis. 既往膝关节手术增加膝关节置换术后翻修、感染、疼痛和僵硬的风险:一项系统回顾和荟萃分析。
IF 2.4 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-09-30 DOI: 10.1186/s12891-025-09060-6
Yanlun Li, Asha Ajia, Zhongna Wu, Jianhui Fan, Min Wu, Pengyu Mao, Feng Yang, Qin He, Pingxi Wang
{"title":"Previous knee surgery increases risks of revision, infection, pain and stiffness after knee replacement arthroplasty: a systematic review and meta-analysis.","authors":"Yanlun Li, Asha Ajia, Zhongna Wu, Jianhui Fan, Min Wu, Pengyu Mao, Feng Yang, Qin He, Pingxi Wang","doi":"10.1186/s12891-025-09060-6","DOIUrl":"10.1186/s12891-025-09060-6","url":null,"abstract":"<p><strong>Background: </strong>Knee replacement arthroplasty(KRA), including Total knee arthroplasty (TKA) and Unicompartmental knee arthroplasty (UKA), is the primary method for treating end-stage knee osteoarthritis (KOA). However, a history of previous knee surgeries (such as knee arthroscopy, ligament reconstruction, meniscectomy, high tibial osteotomy, etc.) may potentially affect functional recovery and complication risks after knee replacement. Although some studies have proposed such associations, the existing evidence remains controversial, and there is a lack of systematic quantitative analysis. This study aims to assess the impact of previous knee surgery on functional outcomes and complications following KRA.</p><p><strong>Methods: </strong>Following the PRISMA Guidelines, a systematic search was conducted in PubMed, Embase, Cochrane Library, and Web of Science databases up to August 4, 2024, for relevant studies. Demographic data, postoperative complications, and functional changes after primary KRA were evaluated in patients with and without a history of previous knee surgery. Statistical analysis of the included studies was performed using Stata 15.1 software. The Newcastle-Ottawa Scale (NOS) was used to assess the quality of the studies.</p><p><strong>Results: </strong>This meta-analysis included 28 studies with 703,103 patients (35,535 with a history of previous knee surgery and 667,568 primary KRA patients). Compared to the primary knee surgery group, the previous knee surgery group had significantly higher rates of prosthetic aseptic revision (RR(95%CI) = 1.45 (1.18-1.78)) (relative risk, RR; Confidence Interval, CI), infection (RR(95%CI) = 1.36 (1.11-1.67)), knee stiffness (RR(95%CI) = 1.73 (1.02-2.96)), and knee pain (RR(95%CI) = 1.21 (1.08-1.34)). However, there were no significant differences in changes in Knee Society Score (KSS) function (WMD(95%CI) = -0.51 (-1.73 to 0.72)) (weighted mean difference, WMD), KSS pain score (WMD(95%CI) = 0.41 (-2.97 to 3.79)), or other knee function scores.</p><p><strong>Conclusion: </strong>Patients with a history of previous knee surgery have a higher likelihood of prosthetic revision, a greater risk of surgical site infections or periprosthetic infections, and a significantly higher incidence of knee stiffness and knee pain following KRA.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"869"},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel fat infiltration combined with muscle parameters for predicting postoperative complications following total knee arthroplasty: a retrospective study. 新的脂肪浸润结合肌肉参数预测全膝关节置换术后并发症:一项回顾性研究。
IF 2.4 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-09-29 DOI: 10.1186/s12891-025-09144-3
Jian Chen, Siqi Zhang, Chunhui Ma, Zeze Fu
{"title":"Novel fat infiltration combined with muscle parameters for predicting postoperative complications following total knee arthroplasty: a retrospective study.","authors":"Jian Chen, Siqi Zhang, Chunhui Ma, Zeze Fu","doi":"10.1186/s12891-025-09144-3","DOIUrl":"10.1186/s12891-025-09144-3","url":null,"abstract":"","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"862"},"PeriodicalIF":2.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aortic dissection disguised as musculoskeletal condition: a case report and review of literature. 伪装成肌肉骨骼疾病的主动脉夹层一例报告及文献复习。
IF 2.4 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-09-29 DOI: 10.1186/s12891-025-09135-4
Xiao-Dan Li, Ze-Jian Chen
{"title":"Aortic dissection disguised as musculoskeletal condition: a case report and review of literature.","authors":"Xiao-Dan Li, Ze-Jian Chen","doi":"10.1186/s12891-025-09135-4","DOIUrl":"10.1186/s12891-025-09135-4","url":null,"abstract":"<p><strong>Background: </strong>Acute aortic dissection (AAD) is a life-threatening cardiovascular emergency frequently associated with misdiagnosis and delayed treatment. This paper aims to illustrate the diagnostic challenges of AAD in rehabilitation settings by presenting a case with atypical musculoskeletal symptoms and emphasize the importance of considering vascular emergencies with literature review.</p><p><strong>Methods: </strong>A 46-year-old male presented to a rehabilitation center with migrating right shoulder pain and proximal weakness. Initial complaint suggested a musculoskeletal disorder; however, further evaluation revealed hypertension, tachycardia, and migratory, intensifying pain. A subsequent computed tomography angiography confirmed AAD. The patient underwent urgent Sun's procedure, including ascending aorta and total arch replacement with stented elephant trunk implantation, which was followed by multidisciplinary rehabilitation due to the secondary ischemic stroke.</p><p><strong>Results: </strong>The patient's early symptoms closely mimicked musculoskeletal disorders, which delayed his prioritization of seeking medical service. After cardiovascular evaluation and successful aortic repair, the AAD was stabilized. However, he later developed right-sided hemiplegia as a secondary complication and was referred back for neurological rehabilitation, which included repetitive task training, robot-assisted therapy, and functional electrical stimulation. Three months post-surgery, he demonstrated significant functional recovery, with Fugl-Meyer Assessment scores improving from 12/66 to 58/66 for the upper extremity and from 17/34 to 32/34 for the lower extremity.</p><p><strong>Conclusion: </strong>This case and literature review highlight the diagnostic challenges of AAD presenting as musculoskeletal pain and underscores the need for rehabilitation specialists to maintain a broad differential diagnosis. A high index of suspicion is essential for early recognition and timely referral, especially in patients with overlapping symptoms and vascular risk factors.</p><p><strong>Impact: </strong>This case adds to the limited body of evidence on AAD presenting with musculoskeletal complaints and may serve to raise clinical awareness. Further studies, including case series and systematic investigations, are needed to better characterize such atypical presentations and guide diagnostic pathways in rehabilitation settings.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"863"},"PeriodicalIF":2.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How the curve morphology differs between curve types in patients with adolescent idiopathic scoliosis during brace treatment? 青少年特发性脊柱侧凸患者在支架治疗期间不同曲线类型的曲线形态有何不同?
IF 2.4 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-09-25 DOI: 10.1186/s12891-025-08732-7
Wing Ki Cheung, Prudence Wing Hang Cheung, Jason Pui Yin Cheung
{"title":"How the curve morphology differs between curve types in patients with adolescent idiopathic scoliosis during brace treatment?","authors":"Wing Ki Cheung, Prudence Wing Hang Cheung, Jason Pui Yin Cheung","doi":"10.1186/s12891-025-08732-7","DOIUrl":"10.1186/s12891-025-08732-7","url":null,"abstract":"<p><strong>Background: </strong>Changes in coronal curve type and curve span may be linked to spinal and rib cage deformities. Therefore, it is crucial to comprehend the potential impact of these changes on brace treatment. This study aims to investigate the relationship between curve progression and change in coronal curve type and curve span in braced patients, and to compare the coronal balance and change in apical vertebral between patients with and without curve pattern change.</p><p><strong>Methods: </strong>Two hundred seventeen patients who fulfilled the Scoliosis Research Society brace referral criteria were recruited. Radiographs at prebrace and brace weaning were assessed. Patients were classified into three groups based on the curve pattern at prebrace: major thoracic (MT), major lumbar (ML) and double major (DM). Change in coronal curve referred to curve of the greatest magnitude changes from thoracic to lumbar or vice versa. Change in curve span defined as change of at least two vertebral levels in the end vertebra of the curve. Change in apical vertebrae referred to change of at least one vertebral level. The association between coronal imbalance, major curve progression and regression, change in coronal curve type, change in curve span, change in apical vertebrae, and curve type were studied using Chi-square test. Multivariable logistic regression was used to predict curve progression at brace wean in each curve type.</p><p><strong>Results: </strong>The major lumbar group exhibited a higher risk of coronal imbalance (Listing-MT: 5.6% vs ML: 37.7% vs DM: 23.5%, p < 0.001 and truncal shift-MT: 6.9% vs ML: 27.3% vs DM: 2.9%, p < 0.001) and changes in apical vertebrae (MT: 30.6% vs ML: 58.4% vs DM: 45.6%, p = 0.003). The double major group had a greater likelihood of experiencing changes in the coronal curve type (MT: 0% vs ML: 15.6% vs DM: 25%, p < 0.001) and major curve progression (MT: 23.6% vs ML: 22.1% vs DM: 52.9%, p < 0.001). In the major thoracic group, predictive factors for curve progression included being female, having poor brace compliance, and no change in curve span. However, no significant relationships were found for the major lumbar group. Patients with a larger prebrace major Cobb angle, larger thoracic kyphosis and poor brace compliance from double major group were more likely to experience curve progression.</p><p><strong>Conclusions: </strong>This study suggests that each curve type undergoes distinct changes during bracing. Future studies should consider the influence of curve type in study design and address the challenges associated with each type.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"858"},"PeriodicalIF":2.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship of total and regional lean body mass with knee pain and function in patients with knee osteoarthritis: a cross-sectional study. 膝关节骨性关节炎患者总瘦体重和局部瘦体重与膝关节疼痛和功能的关系:一项横断面研究。
IF 2.4 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-09-25 DOI: 10.1186/s12891-025-08739-0
Beibei Tong, Yetian Liang, Peiyuan Liu, Mengqi Wang, Dan Li, Wen Zeng, Disha Zhu, Tao Liu, Hongbo Chen, Shaomei Shang
{"title":"Relationship of total and regional lean body mass with knee pain and function in patients with knee osteoarthritis: a cross-sectional study.","authors":"Beibei Tong, Yetian Liang, Peiyuan Liu, Mengqi Wang, Dan Li, Wen Zeng, Disha Zhu, Tao Liu, Hongbo Chen, Shaomei Shang","doi":"10.1186/s12891-025-08739-0","DOIUrl":"10.1186/s12891-025-08739-0","url":null,"abstract":"<p><strong>Background: </strong>Lean body mass is crucial for maintaining muscle strength, particularly in patients with knee osteoarthritis. While it provides a protective effect against knee pain and functional decline, the specific relationship between total and regional lean body mass and knee pain and function in these patients remains unclear. This study aimed to investigate the relationship between total and regional lean body mass, and knee pain and function in patients with knee osteoarthritis, with subgroup analyses conducted based on BMI and sex.</p><p><strong>Methods: </strong>A total of 337 patients were included in the analyses. Clinical information and participant demographics were described descriptively. Linear regression analyses were conducted to investigate the relationship between total and regional lean body mass, and knee pain and function in patients with knee osteoarthritis, with subgroup analyses performed based on BMI and sex.</p><p><strong>Results: </strong>The average age of 337 subjects was 63.8 ± 8.1 years, with 260 women (77.2%). Based on BMI, 279 subjects were classified as overweight or obese, and 58 were classified as having normal weight. In subjects who were overweight or obese, a weak negative correlation was found between trunk lean body mass and self-reported knee function decline (β = -0.28, 95% CI: -1.81, -0.15), and knee pain (β = -0.28, 95% CI: -0.58, -0.04). This negative association was more pronounced in male subjects who were overweight or obese (self-reported decreased knee function (β = -0.75, 95% CI: -4.95, -1.50) and knee pain (β = -0.64, 95% CI: -1.43, -0.32)).</p><p><strong>Conclusion: </strong>Trunk lean body mass had the largest positively association with improved self-reported knee function and reduced knee pain compared with other regions, which was most pronounced in male subjects with overweight or obese.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"859"},"PeriodicalIF":2.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative evaluation of long-term spinopelvic morphology after salter and pemberton osteotomies in DDH patients: follow-up of 8 years. DDH患者salter和pemberton截骨术后长期骨盆形态的比较评价:随访8年。
IF 2.4 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-09-25 DOI: 10.1186/s12891-025-09097-7
Basri Pür, Sinan Yılar, İbrahim Dağ, Kamber Kaşali, Ahmed Arif Uzun, Eyüp Şenocak, Mehmet Demir
{"title":"Comparative evaluation of long-term spinopelvic morphology after salter and pemberton osteotomies in DDH patients: follow-up of 8 years.","authors":"Basri Pür, Sinan Yılar, İbrahim Dağ, Kamber Kaşali, Ahmed Arif Uzun, Eyüp Şenocak, Mehmet Demir","doi":"10.1186/s12891-025-09097-7","DOIUrl":"10.1186/s12891-025-09097-7","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to compare the long-term effects of Salter and Pemberton osteotomies on spinopelvic alignment and the development of scoliosis in patients with developmental dysplasia of the hip (DDH).</p><p><strong>Methods: </strong>This retrospective study included 127 patients who underwent unilateral Salter or Pemberton osteotomy between 2004 and 2012 at 1-3 years of age. Fifty-five patients treated non-surgically using a Pavlik harness or casting served as the control group. Patients were grouped into unilateral Pemberton osteotomy (Group 1), unilateral Salter osteotomy (Group 2), and controls (Group 3). Long-term radiographic outcomes were assessed using Cobb angle (CA), lumbar lordosis (LL), iliac tilt (IT), sacral tilt (ST), pelvic obliquity (PO), sacral slope (SS), and leg length discrepancy (LLD). Propensity Score Matching (PSM) technique was used to balance the demographic differences between groups, including age, sex, and follow-up duration.</p><p><strong>Results: </strong>The incidence of scoliosis was significantly higher in the Salter group compared to the Pemberton and control groups (p < 0.05). Significant deviations in iliac tilt and sacral tilt were also noted in the Salter group (p < 0.01). Spinopelvic parameters in the Pemberton group were more comparable to those of the non-operated control group. Logistic regression analysis revealed that increased sacral tilt, iliac tilt, and pelvic obliquity were independent risk factors for scoliosis (p < 0.01, p < 0.05, and p < 0.05, respectively).</p><p><strong>Conclusions: </strong>Salter osteotomy may increase the risk of long-term spinopelvic misalignment and scoliosis in patients with DDH. In contrast, Pemberton osteotomy appears to better preserve spinopelvic alignment. These findings suggest that long-term axial alignment should be considered during surgical planning in DDH management.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"860"},"PeriodicalIF":2.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An analysis of radiologic and anatomical parameters associated with traumatic isolated medial meniscus tear patterns in Ligament-Intact knees. 韧带完整膝关节外伤性孤立的内侧半月板撕裂模式的放射学和解剖学参数分析。
IF 2.4 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-09-25 DOI: 10.1186/s12891-025-09122-9
Fatih Golgelioglu, Sinan Oguzkaya, Mehmet Fatih Uzun, Anıl Aydın, Barıs Korkmaz, Erdal Uzun
{"title":"An analysis of radiologic and anatomical parameters associated with traumatic isolated medial meniscus tear patterns in Ligament-Intact knees.","authors":"Fatih Golgelioglu, Sinan Oguzkaya, Mehmet Fatih Uzun, Anıl Aydın, Barıs Korkmaz, Erdal Uzun","doi":"10.1186/s12891-025-09122-9","DOIUrl":"10.1186/s12891-025-09122-9","url":null,"abstract":"<p><strong>Background: </strong>The purpose of the study was to analyze the radiologic and anatomical parameters associated with traumatic isolated medial meniscus tear patterns in ligament-intact knees.</p><p><strong>Methods: </strong>This retrospective case-control study included 195 patients aged 18-45 years who experienced traumatic knee pain and were diagnosed with isolated medial meniscal tears via magnetic resonance imaging (MRI) between 2014 and 2021. Patients were categorized according to tear patterns into longitudinal, bucket-handle, radial, and complex tear groups. The control group consisted of 61 healthy individuals aged 18-45 years who underwent knee MRI for unrelated symptoms and had no detectable intra- or extra-articular knee abnormalities. Radiologic and anatomical parameters were measured on MRI scans, and statistical analyses were performed using Kruskal-Wallis tests, multinomial logistic regression analysis, and Spearman's correlation tests.</p><p><strong>Results: </strong>No significant differences were observed between the groups in terms of age, gender, and BMI (P < 0.05). Study results indicated that increased tibial tubercle-to-trochlear groove (TT-TG) distance (P < 0.001) and medial tibial slope (P < 0.001) are risk factors for developing longitudinal, bucket-handle, and complex medial meniscus tears. Additionally, low medial meniscal bone angle (MBA) (P = 0.019) and medial meniscal cartilage angle (MCA) (P = 0.004) values were linked to an increased risk of radial tears. These findings suggest that specific anatomical and radiological factors predispose individuals to certain types of medial meniscus tears.</p><p><strong>Conclusion: </strong>In ligament-intact knees, increased TT-TG distance and increased medial tibial slope were associated with longitudinal, bucket-handle, and complex tear patterns in the medial meniscus, while low MBA and MCA values were associated with radial tears. Findings of this study offer valuable insights for orthopedics and traumatology specialists in enhancing prevention and management strategies for medial meniscal tears, laying a foundational basis for further research.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"861"},"PeriodicalIF":2.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction Note: Translation and psychometric evaluation of the Persian version of Knee Outcome Survey-Activities of Daily Living Scale (KOS-ADLS). 撤稿注:波斯语版膝关节预后调查-日常生活活动量表(KOS-ADLS)的翻译和心理测量学评估。
IF 2.4 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-09-24 DOI: 10.1186/s12891-025-09200-y
Hooman Minoonejad, Mohammad Amin Henteh, Roshanak Keshavarz, Mehdi Safarzadeh, Ali Montazeri
{"title":"Retraction Note: Translation and psychometric evaluation of the Persian version of Knee Outcome Survey-Activities of Daily Living Scale (KOS-ADLS).","authors":"Hooman Minoonejad, Mohammad Amin Henteh, Roshanak Keshavarz, Mehdi Safarzadeh, Ali Montazeri","doi":"10.1186/s12891-025-09200-y","DOIUrl":"10.1186/s12891-025-09200-y","url":null,"abstract":"","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"856"},"PeriodicalIF":2.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12459046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the therapeutic efficacy of leukocyte-poor and leukocyte-rich platelet-rich plasma in rabbit knee osteoarthritis and the study of autophagy mechanism. 贫白细胞与富白细胞富血小板血浆治疗兔膝骨性关节炎的疗效比较及自噬机制的研究。
IF 2.4 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-09-24 DOI: 10.1186/s12891-025-08906-3
Li Sun, Yaomin Wang, Kefan Zhang, Xinlong Chen, Hui Shi
{"title":"Comparison of the therapeutic efficacy of leukocyte-poor and leukocyte-rich platelet-rich plasma in rabbit knee osteoarthritis and the study of autophagy mechanism.","authors":"Li Sun, Yaomin Wang, Kefan Zhang, Xinlong Chen, Hui Shi","doi":"10.1186/s12891-025-08906-3","DOIUrl":"10.1186/s12891-025-08906-3","url":null,"abstract":"<p><p>Osteoarthritis of the knee (KOA) is a degenerative disease characterized by the deterioration, destruction, and proliferation of articular cartilage and synovium. Autophagy, a crucial intracellular homeostatic mechanism, significantly contributes to the pathogenesis of OA. Platelet-rich plasma (PRP), derived from autologous blood, contains a high concentration of platelets that secrete various growth factors, promoting the regeneration and repair of joint structures. In this experiment, we compared leukocyte-rich platelet-rich plasma (LR-PRP) with leukocyte-poor platelet-rich plasma (LP-PRP) in a rabbit osteoarthritis model induced by papain to investigate the therapeutic efficacy and mechanism of action of platelet-rich plasma on osteoarthritis. Additionally, we analyzed whether different leukocyte concentrations in platelet-rich plasma would affect the treatment outcomes. Papain was injected into the knee joints of 32 rabbits to induce osteoarthritis, and the animals were cultured until bone maturity. LP-PRP and LR-PRP were prepared using different centrifugation methods and injected into the knee joint cavity. Eight weeks after the injection, various analyses were performed on the rabbit knee joint synovium and cartilage. These included HE staining, immunohistochemistry for PI3K, AKT, mTOR, LC3-II, MMP-13, toluidine blue staining, and ELISA for IL-1β and TNF-α in joint fluid. The synovial membrane was scored using the Krenn score, and cartilage was evaluated with the Mankin pathology score. Quantitative analysis of immunohistochemistry was conducted using ImageJ image processing software. The rabbit osteoarthritis model was successfully established by injecting papain into the knee joint cavity. All indices showed significant differences between the model group and the control group (P < 0.05). Both LP-PRP and LR-PRP exhibited therapeutic effects compared to the model group (P < 0.05). The concentrations of IL-1β and TNF-α in the LP-PRP group were significantly lower than those in the LR-PRP group (P < 0.05). However, no significant differences were observed in the morphology of the synovial membrane, cartilage, and other indices between the LR-PRP and LP-PRP groups (P > 0.05).</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"857"},"PeriodicalIF":2.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12461960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Video-based physiotherapy assessment of knee osteoarthritis in patients with knee pain: a validity and reliability pilot study. 基于视频的膝骨关节炎膝痛患者物理治疗评估:有效性和可靠性的初步研究。
IF 2.4 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-09-23 DOI: 10.1186/s12891-025-09201-x
Christin Heina, Susanne Beischer, Chan-Mei Ho-Henriksson, Elvira Lange
{"title":"Video-based physiotherapy assessment of knee osteoarthritis in patients with knee pain: a validity and reliability pilot study.","authors":"Christin Heina, Susanne Beischer, Chan-Mei Ho-Henriksson, Elvira Lange","doi":"10.1186/s12891-025-09201-x","DOIUrl":"10.1186/s12891-025-09201-x","url":null,"abstract":"<p><strong>Background: </strong>Digital health technologies are advancing rapidly, with an increasing number of physiotherapists favoring real-time, video-based platforms over telephone-based modalities. Osteoarthritis affects an estimated 595 million individuals worldwide, with approximately 62% of cases involving the knee joint. However, evidence regarding the validity and reliability of video-based assessments for knee osteoarthritis (KOA) remains scarce. The purpose of this pilot study was to explore the feasibility of video-based physiotherapy assessment of KOA in patients with knee pain. Additionally, we aimed to provide preliminary data on its concurrent validity and interrater reliability compared with conventional face-to-face assessment.</p><p><strong>Methods: </strong>A cross-sectional validity and reliability pilot study was conducted in June 2024. Participants were recruited through public advertisements. Eligible individuals were aged 45 years or older and reported knee pain. Each participant underwent both a real-time video-based physiotherapy assessment and a conventional, face-to-face assessment. The video-based assessments were recorded for later analysis. Concurrent validity was examined by determining the exact or potential agreement between the video-based and face-to-face assessments. Interrater reliability was evaluated by comparing the live video-based assessments with those obtained from the recorded video-based assessments.</p><p><strong>Results: </strong>For concurrent validity, exact agreement was observed in 28 of 35 cases (80%; κ = 0.35), indicating fair agreement. Potential agreement was achieved in 33 of 35 cases (94%; κ = 0.64), indicating substantial agreement. Interrater reliability demonstrated exact agreement in 25 of 29 cases (86%; κ = 0.52), corresponding to moderate agreement. Potential agreement for interrater reliability was observed in 27 of 29 cases (93%; κ = 0.63), corresponding to substantial agreement.</p><p><strong>Conclusions: </strong>Video-based physiotherapy assessment appears feasible and may provide preliminary indications of validity for diagnosing KOA in individuals with nontraumatic knee pain. The results suggest acceptable interrater agreement and highlight the need for more standardized digital assessment protocols to ensure consistent and reliable use in clinical practice.</p><p><strong>Trial registration: </strong>ISRCTN Registry (ISRCTN41057250), 09/05/2025. Retrospectively registered. Prospectively registered in FoU in VGR (researchweb.org) 282608, Date of registration 26/03/2024.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"853"},"PeriodicalIF":2.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信