BMC Musculoskeletal Disorders最新文献

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Comparative analysis of intraoperative fluoroscopic vs. Anatomical landmark positioning methods in MPFL reconstruction for recurrent patellar dislocation. 术中透视与解剖标记定位方法在复发性髌骨脱位MPFL重建中的比较分析。
IF 2.4 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-09-30 DOI: 10.1186/s12891-025-09156-z
Ruke Lin, Ping Fu, Xinfu Zhang, Yajie Wu, Xibei Lin, Daohong Zhao
{"title":"Comparative analysis of intraoperative fluoroscopic vs. Anatomical landmark positioning methods in MPFL reconstruction for recurrent patellar dislocation.","authors":"Ruke Lin, Ping Fu, Xinfu Zhang, Yajie Wu, Xibei Lin, Daohong Zhao","doi":"10.1186/s12891-025-09156-z","DOIUrl":"10.1186/s12891-025-09156-z","url":null,"abstract":"<p><strong>Objective: </strong>A retrospective analysis was conducted to evaluate the application of the intraoperative fluoroscopic positioning and anatomical landmark positioning methods in medial patellofemoral ligament (MPFL) reconstruction for recurrent patellar dislocation. The aim was to summarize the positioning accuracy and clinical efficacy of each method, to serve as a reference for femoral positioning.</p><p><strong>Method: </strong>We conducted a retrospective analysis of a cohort comprising 75 patients who underwent treatment for recurrent patellar dislocation at our institution between January 2014 and September 2020.Based on the different positioning methodologies utilized for identifying the MPFL femoral footprint, the included patients were systematically allocated to either the fluoroscopy group or the palpation group.Preoperative evaluations and assessments at the latest follow-up encompassed the International Knee Documentation Committee (IKDC) score, Lysholm score, and Kujala score for both groups.We utilized immediate postoperative CT scans for our evaluations. A total of 48 knee 3D-CT scans were acquired using Mimics Medical 21.0 for both groups. From these scans, we constructed a standard lateral Schottle point on a 3D-CT image. To assess the relative positions between the actual and standard location points in both groups, we established a coordinate system based on a simplified, constructed standard point baseline (as illustrated in Chart e). Subsequently, the relative positions of the actual points were evaluated.</p><p><strong>Result: </strong>All 75 patients were followed up for a period ranging from 36 to 96 months( mean: 62.27 ± 21.36 months). Significant improvements were observed in the IKDC score, Lysholm score, and Kujala score from preoperative to the latest follow-up (p < 0.05) (Table 2), indicating statistical significance.Furthermore, the latest follow-up revealed no significant differences in knee function scores between the two groups (P > 0.05) (Table 3). Similarly, the latest evaluation showed no significant differences in knee function scores between patients undergoing MPFLR and MPFLR + TTO In their respective groups (P > 0.05) (Table 4).CT-3D reconstruction was conducted on 48 postoperative patients (24 in the fluoroscopy group and 24 in the palpation group). Evaluation of the positioning revealed that most cases in the palpation group were located in quadrants 1 and 3, whereas those in the fluoroscopy group were primarily distributed across quadrants 1, 3, and 4 (p < 0.05), indicating statistical significance.In the palpation group, the isometric distance was 3.90 ± 2.17 mm, with an isometric rate of 75%. In the fluoroscopy group, the isometric distance was 7.55 ± 3.94 mm, with an isometric rate of 29.2%.The femoral tunnel isometric rate was significantly higher in the palpation group, at 75%, compared to 29.2% in the fluoroscopy group. among the two positioning methods, there was no statistical dif","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"872"},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and validation of a nomogram model for predicting postoperative nonunion in femoral shaft fractures. 预测股骨干骨折术后骨不连的nomogram模型的建立与验证。
IF 2.4 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-09-30 DOI: 10.1186/s12891-025-09064-2
Zhilong Hao, Yefan Zhang, Jiahao Zeng, Chao Yang, Haifeng Dang, Donglin Li, Junjun Fan
{"title":"Development and validation of a nomogram model for predicting postoperative nonunion in femoral shaft fractures.","authors":"Zhilong Hao, Yefan Zhang, Jiahao Zeng, Chao Yang, Haifeng Dang, Donglin Li, Junjun Fan","doi":"10.1186/s12891-025-09064-2","DOIUrl":"10.1186/s12891-025-09064-2","url":null,"abstract":"<p><strong>Objective: </strong>To identify independent risk factors for nonunion following femoral shaft fracture surgery and develop a clinically applicable nomogram model for personalized risk prediction.</p><p><strong>Methods: </strong>A retrospective cohort study included 804 patients with femoral shaft fractures treated at Xijing Hospital (2014-2020). Patients were divided into development (n = 561) and validation (n = 243) cohorts. Variables were screened via LASSO regression, and a nomogram was constructed using multivariate logistic regression. Model performance was assessed using ROC curves, calibration plots, Hosmer-Lemeshow tests, and decision curve analysis (DCA).</p><p><strong>Results: </strong>Five independent predictors of nonunion were identified: smoking. (OR = 3.094, 95% CI:1.790-5.350), high-energy injury (OR = 2.454, 95% CI:1.167-5.159), multiple injuries (OR = 2.897, 95% CI:1.580-5.312), internal fixation method (OR = 1), and fixation failure (OR = 3.437, 95% CI:1.51'. 9-7.778). The nomogram demonstrated excellent discrimination. (AUC = 0.828 in development, 0.835 in validation cohorts) and calibration (Hosmer-Lemeshow P = 0.463 and P = 0.858, respectively). DCA confirmed clinical utility at threshold probabilities > 15%.</p><p><strong>Conclusion: </strong>This nomogram provides a practical tool for predicting nonunion risk in femoral shaft fractures, enabling early intervention for high-risk patients.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"874"},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Collaborative model of care between orthopaedics and allied health professionals in knee osteoarthritis (CONNACT): process evaluation of an effectiveness-implementation hybrid randomized control trial. 膝关节骨性关节炎骨科和联合卫生专业人员之间的协作治疗模式(connect):一项有效性-实施混合随机对照试验的过程评估。
IF 2.4 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-09-30 DOI: 10.1186/s12891-025-08925-0
Bryan Yijia Tan, Eugene Yong Sheng Woon, Su-Yin Yang, Konstadina Griva, Soren T Skou, David Hunter, Andrew M Briggs, Julian Thumboo, Josip Car
{"title":"Collaborative model of care between orthopaedics and allied health professionals in knee osteoarthritis (CONNACT): process evaluation of an effectiveness-implementation hybrid randomized control trial.","authors":"Bryan Yijia Tan, Eugene Yong Sheng Woon, Su-Yin Yang, Konstadina Griva, Soren T Skou, David Hunter, Andrew M Briggs, Julian Thumboo, Josip Car","doi":"10.1186/s12891-025-08925-0","DOIUrl":"10.1186/s12891-025-08925-0","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the implementation process of a community-based, multidisciplinary intervention (CONNACT) through a randomized controlled trial (RCT) in order to contextualize the RCT outcomes and inform implementation opportunities.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study is an embedded qualitative process evaluation of the CONNACT effective-implementation hybrid RCT. Semi-structured interviews with 22 intervention patients and 14 healthcare professionals were conducted. Interviews were audio-recorded, transcribed and translated using framework analysis. Data was analysed thematically and the emergent themes were organised into the conceptual domains of RE-AIM. An explanatory sequential methods approach was used to discuss the Reach and Effectiveness domains of RE-AIM, whereby quantitative data (i.e. recruitment logs and published quantitative results) was discussed in relation to this study's qualitative data.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Reach: 55.4% of the patients who met the inclusion criteria participated, while work or family commitments and disinterest in physiotherapy are the primary reasons for declining participation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Effectiveness: &lt;/strong&gt;CONNACT intervention is not superior to control hospital-based usual care in terms of pain, function, and quality of life, but superior in physical performance, knee satisfaction, global perceived effect and positive dietary change. The results and effectiveness of CONNACT are presented and discussed in a related publication. Adoption: Healthcare professionals proposed changes for long-term sustainability (transdisciplinary approach, expert patients) despite their strong support for CONNACT. Implementation (context): A spectrum of passive-resigned and impatient-unrealistic mindsets, pain beliefs, and expectations was elucidated. Implementation (mechanism of impact): Focus on patient education and empowerment encouraged patients to actively accept their condition and practice self-efficacy. Although group classes are a source of support, motivation, and positive peer pressure, several patients preferred personalized treatments. CONNACT's synergistic nature benefitted patients who are more complex. Maintenance (patient-level): Patients highlighted the importance of incorporating exercise into their regular routines, but lack of time and inertia remain as significant barriers.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The themes have allowed a better understanding of the RCT primary and secondary outcomes and informed the next phase of implementation. CONNACT and similar interventions should identify and address reasons for refusing participation [Reach]; improve group classes with initial evaluations, equal attention paid to patients, tailored exercises, and acknowledge progress [Effectiveness, Implementation]; and adopt a streamlined resource-efficient transdisciplinary design [Maintenance].&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Trial registration: &lt;/strong&gt;This study, which primari","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"876"},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tongue myositis in dermatomyositis with anti-PM-Scl 75 antibody: two case reports. 皮肌炎伴抗pm - scl75抗体并发舌肌炎2例报告。
IF 2.4 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-09-30 DOI: 10.1186/s12891-025-09114-9
Chao Sun, Xiaolan Tian, Shanshan Li, Guochun Wang, Xin Lu
{"title":"Tongue myositis in dermatomyositis with anti-PM-Scl 75 antibody: two case reports.","authors":"Chao Sun, Xiaolan Tian, Shanshan Li, Guochun Wang, Xin Lu","doi":"10.1186/s12891-025-09114-9","DOIUrl":"10.1186/s12891-025-09114-9","url":null,"abstract":"<p><strong>Background: </strong>Dermatomyositis (DM) is a heterogeneous disease characterized by skin rash and muscle weakness. Although tongue disorders have been documented in idiopathic inflammatory myopathies (IIM), biopsy-confirmed tongue myositis remains exceedingly rare, and no reports have been published in patients with DM.</p><p><strong>Case presentation: </strong>This study describes two rare cases of anti-PM-Scl 75 antibody-positive dermatomyositis with tongue involvement and dysphagia. In case 1, muscle weakness and skin rash improved after the initial therapy. However, the patient developed tongue atrophy, severe pharyngeal dysphagia (Functional Oral Intake Scale (FOIS) level = 3) and dysarthria (Frenchay Dysarthria Assessment scale (FDA) score = 13) during the tapering of glucocorticoid. Escalating glucocorticoids and adding rituximab improved her swallowing (FOIS level = 6) and speech (FDA score = 23) function, though a limited improvement of tongue atrophy. Case 2 presented with severe skin rash, muscle weakness and elevated CK levels, accompanied by tongue redness and swelling, mild pharyngeal dysphagia (FOIS level = 5) and dysarthria (FDA score = 20) at disease onset. With the treatment of glucocorticoid, tacrolimus and intravenous immunoglobulin (IVIG), the patient achieved complete remission.</p><p><strong>Conclusion: </strong>Tongue myositis may occur in DM and could serve as a potential indicator of disease activity. Early recognition may be beneficial and biological agents warrant further investigation in refractory cases.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"868"},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical factors associated with radiographic severity of progressive temporomandibular joint osteoarthritis: a retrospective CBCT study. 与进行性颞下颌关节骨关节炎放射学严重程度相关的临床因素:回顾性CBCT研究。
IF 2.4 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-09-30 DOI: 10.1186/s12891-025-09149-y
Rüdiger Emshoff, Ansgar Rudisch, Stefan Bertram
{"title":"Clinical factors associated with radiographic severity of progressive temporomandibular joint osteoarthritis: a retrospective CBCT study.","authors":"Rüdiger Emshoff, Ansgar Rudisch, Stefan Bertram","doi":"10.1186/s12891-025-09149-y","DOIUrl":"10.1186/s12891-025-09149-y","url":null,"abstract":"<p><strong>Background: </strong>Temporomandibular joint (TMJ) osteoarthritis (OA) is a progressive deteriorative joint disorder characterized by loss of cartilage and alterations in subchondral bone architecture. The study aimed to identify clinical baseline parameters most closely associated with radiographic indicators of deteriorative OA severity.</p><p><strong>Methods: </strong>The study consisted of 233 patients with unilateral TMJ arthralgia (204 females, 29 males; mean age 41.9 ± 18.1 years) meeting the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) Axis I. Following clinical examination, each patient underwent cone beam computed tomography (CBCT) evaluation of both TMJs. A composite subchondral bone alteration (SBA) grading score of progressive deteriorative OA changes was used including the following items: erosion, resorption, cyst, sclerosis, osteophyte, and flattening; the maximum possible score was 4.</p><p><strong>Results: </strong>Multivariate ordinal regression analysis identified the following factors significantly associated with the severity of condylar SBAs: older age (> 45 years) (odds ratio [OR], 4.53; p < 0.001), having concomitant arthralgia (OR, 1.85; p = 0.035), and higher number of condylar side-related missing posterior teeth (> 4) (OR, 1.80; p = 0.039).</p><p><strong>Conclusions: </strong>The data Suggest that patients older than 45 years who have a concurrent arthralgia, and missing more than 4 posterior teeth may have an increased risk of developing progressive SBAs. By focusing on these clinical factors, patients should be advised of their heightened risk of developing deteriorative SBAs to avoid delayed diagnosis and treatment. Ongoing research is warranted to improve the model, and prove the validity and reliability of the model.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"880"},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multistage surgical strategy combining bone transport and antibiotic cement in a complex lower extremity crush injury: achieving limb salvage and infection control. 结合骨运输和抗生素水泥治疗复杂下肢挤压伤的多阶段手术策略:实现肢体保留和感染控制。
IF 2.4 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-09-30 DOI: 10.1186/s12891-025-09138-1
Weishuai Zhang, Xuchao Lu, Nannan Yang, Xianyou Zhu, Jian Cheng
{"title":"Multistage surgical strategy combining bone transport and antibiotic cement in a complex lower extremity crush injury: achieving limb salvage and infection control.","authors":"Weishuai Zhang, Xuchao Lu, Nannan Yang, Xianyou Zhu, Jian Cheng","doi":"10.1186/s12891-025-09138-1","DOIUrl":"10.1186/s12891-025-09138-1","url":null,"abstract":"<p><strong>Background: </strong>High-energy lower extremity crush injuries with concurrent infection and segmental bone defects present significant therapeutic challenges, often complicated by recalcitrant osteomyelitis and compromised bone healing. Traditional approaches frequently fail to achieve simultaneous infection eradication and structural reconstruction. This case demonstrates how a staged surgical protocol combining bone transport and antibiotic cement spacer technology addresses these dual challenges.</p><p><strong>Case report: </strong>A 45-year-old male sustained an open tibiofibular fracture of the left lower extremity with extensive soft tissue loss after a traffic accident. He initial underwent open reduction and internal fixation (ORIF) with titanium plates and external fixation. Subsequently, he developed chronic osteomyelitis caused by Escherichia coli. A multidisciplinary team implemented a four-phase protocol: Phase I (Feb-Jun 2020): Radical debridement, removal of infected titanium plate, split-thickness skin grafting, and triangular external fixation. Phase II (Jun-Jul 2020): Ilizarov circular frame application and vancomycin/tobramycin-impregnated bone cement implantation after further debridement. Phase III (Jul 2020-Mar 2021): Bone transport initiated at 1 mm/day to reconstruct a 20 cm tibial defect using a hybrid Ilizarov-U frame. Phase IV (Mar 2021-Feb 2022): External fixator removal after radiographic consolidation, followed by fibular titanium plate extraction. Postoperative follow-up at 26 months demonstrated complete bony union, resolved infection, and restored ambulatory capacity, with minor limitations in knee/ankle range of motion.</p><p><strong>Conclusion: </strong>This case validates the efficacy of a staged, multidisciplinary approach. It combines aggressive infection control (antibiotic cement spacers and serial debridement) with bone transport techniques for limb salvage in complex crush injuries. The protocol achieved synchronous soft tissue repair and segmental defect reconstruction. This approach emphasizes the critical role of patient compliance, dynamic mechanical stabilization, and incremental soft tissue optimization. This strategy offers a reproducible framework for managing high-energy trauma complicated byosteomyelitis and critical bone loss.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"865"},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-surgical treatment of anterior cruciate ligament tears with percutaneous bone marrow concentrate and platelet products versus exercise therapy: a randomized-controlled, crossover trial with 2-year follow-up. 非手术治疗前交叉韧带撕裂经皮骨髓浓缩液和血小板产品与运动治疗:一项2年随访的随机对照交叉试验
IF 2.4 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-09-30 DOI: 10.1186/s12891-025-09153-2
Christopher J Centeno, Dustin R Berger, John Pitts, Jason Markle, Andrew J Pelle, Matthew Murphy, Ehren Dodson
{"title":"Non-surgical treatment of anterior cruciate ligament tears with percutaneous bone marrow concentrate and platelet products versus exercise therapy: a randomized-controlled, crossover trial with 2-year follow-up.","authors":"Christopher J Centeno, Dustin R Berger, John Pitts, Jason Markle, Andrew J Pelle, Matthew Murphy, Ehren Dodson","doi":"10.1186/s12891-025-09153-2","DOIUrl":"10.1186/s12891-025-09153-2","url":null,"abstract":"<p><strong>Background: </strong>Anterior cruciate ligament (ACL) reconstruction (ACLR) surgery remains the prevailing standard of care for complete ACL ruptures but is not without risk. The aim of this study was to compare non-surgical, autologous bone marrow concentrate (BMC) with platelet products compared to exercise therapy for partial and complete, non-retracted ACL tears without meniscus injuries.</p><p><strong>Methods: </strong>In this randomized-controlled, crossover trial, patients received either exercise therapy or an injection of BMC with platelet products to treat ACL tears. After 3 months, if patients randomized to the exercise group were not satisfied with their improvement, they could crossover to receive the BMC treatment. Patients reported outcomes were completed at pre-treatment, 1-, 3, 6-, 12-, and 24-months of the Numeric Pain Scale (NPS), the International Knee Documentation Committee (IKDC) subjective knee form, Lower Extremity Function Scale (LEFS), and a modified Single Assessment Numeric Evaluation (SANE). MRIs at pre- and post-treatment were assessed using ImageJ software analysis. Complications and surgeries were assessed at each time point.</p><p><strong>Results: </strong>Patients in the BMC group reported significantly greater change scores (from pre-treatment) on LEFS (P = 0.027), and SANE (P = 0.007) at 3 months compared to the exercise group. No significant differences were found between baseline and/or 1- month and 3-month follow-ups for any outcome measure (P > 0.05) in the exercise therapy group. When followed through 2 years, patients who received BMC treatment demonstrated sustained improvements in function and decreases in pain, with patients reporting a median of subjective improvement (SANE) of 90% at the final follow-up. Significant negative correlations were found between age of injury and ΔIKDC ΔLEFS, and SANE (P < 0.05) at the 24-month follow-up with lower ΔPROMs reported by those with older tears the age of tear (> 12 months). Post-treatment MRI provided evidence of significant improvements in ACL integrity. No serious adverse events were reported. Four patients did not respond to BMC treatment and underwent ACL reconstruction without any new reports of knee injuries.</p><p><strong>Conclusions: </strong>The significant improvements in function, pain, and overall improvement in patients receiving BMC and platelets provide evidence of a viable alternative treatment option for patients with ACL tears.</p><p><strong>Trial registration: </strong>NCT01850758; A Randomized Controlled Trial of Regenexx-SD Versus Exercise therapy for Treatment of Partial and Complete, Non-retracted Anterior Cruciate Ligament Tears. Registered May 7, 2013.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"882"},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of mental and physical workload on work function in office workers with musculoskeletal disorders. 身心负荷对肌肉骨骼疾病上班族工作功能的影响。
IF 2.4 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-09-30 DOI: 10.1186/s12891-025-09147-0
Safora Arefian, Marzieh Izadi Laybidi, Mohsen Vahedi, Markus Melloh, Hamid Reza Mokhtarinia
{"title":"Impact of mental and physical workload on work function in office workers with musculoskeletal disorders.","authors":"Safora Arefian, Marzieh Izadi Laybidi, Mohsen Vahedi, Markus Melloh, Hamid Reza Mokhtarinia","doi":"10.1186/s12891-025-09147-0","DOIUrl":"10.1186/s12891-025-09147-0","url":null,"abstract":"<p><strong>Background: </strong>Occupational risk factors, including personal, physical, and psychosocial elements, cumulatively impact impairments and job performance, especially in the presence of pain. This study investigates how demographic characteristics, as well as mental and physical workloads, influence the work function of office workers with musculoskeletal disorders (MSDs).</p><p><strong>Methods: </strong>In this cross-sectional study conducted in Iran, 260 office workers (72% female, mean age 42.6 ± 6.7) participated. Among them, 225 individuals with MSDs in at least two body regions were included in the second phase. Demographic information was self-reported. The prevalence of MSDs, work function, mental and physical workloads were assessed using the Extended Nordic Musculoskeletal Questionnaire (NMQ-E), Work Role Functioning Questionnaire (WRFQ-2), NASA Task Load Index (TLX) questionnaire, and Rapid Office Strain Assessment (ROSA), respectively. Linear and multiple regression analyses were performed to identify significant risk factors.</p><p><strong>Results: </strong>Of the participants, 86.53% reported experiencing pain in at least two body regions during the last year and were included in the second phase. The lower back (57.3%) and neck (50.7%) were the most affected regions during the last year. Regression analysis revealed significant associations between work function and mental workload, physical workload, as well as specific subscales of NASA-TLX (physical and frustration subscales) and ROSA (Chair score, Monitor, and Telephone scores).</p><p><strong>Conclusion: </strong>Both mental and physical workloads were significant independent predictors of poorer work function in office workers with MSDs. These findings underscore the need to address both domains concurrently in ergonomics and occupational health programs.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"867"},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early diagnosis of knee osteoarthritis severity using vision transformer. 视力变换器在膝关节骨关节炎严重程度早期诊断中的应用。
IF 2.4 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-09-30 DOI: 10.1186/s12891-025-09137-2
Punita Panwar, Sandeep Chaurasia, Jayesh Gangrade, Ashwani Bilandi
{"title":"Early diagnosis of knee osteoarthritis severity using vision transformer.","authors":"Punita Panwar, Sandeep Chaurasia, Jayesh Gangrade, Ashwani Bilandi","doi":"10.1186/s12891-025-09137-2","DOIUrl":"10.1186/s12891-025-09137-2","url":null,"abstract":"<p><p>Knee Osteoarthritis (K-OA) is characterized as a progressive joint condition with global prevalence, exhibiting deterioration over time and impacting a significant portion of the population. It happens because joints wear out slowly. The main reason for osteoarthritis is the wearing away of the cushion in the joints, which makes the bones rub together. This causes feelings of stiffness, unease, and difficulty moving. Persons with osteoarthritis find it hard to do simple things like walking, standing, or going up stairs. Besides that, it can also make people feel sad or worried because of the ongoing pain and trouble it causes. Knee osteoarthritis exerts a sustained impact on both the economy and society. Typically, radiologists assess knee health through MRI or X-ray images, assigning KL-grades. MRI excels in visualizing soft tissues like cartilage, menisci, and ligaments, directly revealing cartilage degeneration and joint inflammation crucial for osteoarthritis (OA) diagnosis. In contrast, X-rays primarily show bone, only inferring cartilage loss through joint space narrowing-a late indicator of OA. This makes MRI superior for detecting early changes and subtle lesions often missed by X-rays. However, manual diagnosis of Knee osteoarthritis is laborious and time-consuming. In response, deep learning methodologies such as vision transformer (ViT) has been implemented to enhance efficiency and streamline workflows in clinical settings. This research leverages ViT for Knee Osteoarthritis KL grading, achieving an accuracy of 88%. It illustrates that employing a simple transfer learning technique with this model yields superior performance compared to more intricate architectures.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"884"},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcome of infantile septic arthritis of the hip joint: A two-children medical center's experience. 婴儿感染性髋关节关节炎的结局:一个儿童医疗中心的经验。
IF 2.4 3区 医学
BMC Musculoskeletal Disorders Pub Date : 2025-09-30 DOI: 10.1186/s12891-025-09159-w
Kainan Lin, Yihua Ge, Yufeng Wang, Yunlan Xu, Bingqiang Han
{"title":"Outcome of infantile septic arthritis of the hip joint: A two-children medical center's experience.","authors":"Kainan Lin, Yihua Ge, Yufeng Wang, Yunlan Xu, Bingqiang Han","doi":"10.1186/s12891-025-09159-w","DOIUrl":"10.1186/s12891-025-09159-w","url":null,"abstract":"","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"871"},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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