BMC Musculoskeletal Disorders最新文献

{"title":"Intra-thoracic displacement of scapular lateral margin: a case report and literature review.","authors":"Lin Zhang, Jiaze Peng, Yang Yu, Xianpeng Huang, Fuyin Yang, Chengbing Yang, Caopei Guo, Jiachen Peng","doi":"10.1186/s12891-025-08750-5","DOIUrl":"10.1186/s12891-025-08750-5","url":null,"abstract":"<p><strong>Background: </strong>Cases of scapular fractures with fragments displacing into the thoracic cavity via intercostal spaces are exceedingly rare in clinical practice. According to the literature, there have been no prior reports of distal lateral margin fractures of the scapula that displace into the thoracic cavity.</p><p><strong>Case presentation: </strong>We reported a case of a patient who presented with right shoulder pain and limited mobility after a fall. Examination revealed fractures of the medial and lateral margins of the right scapula, with the distal end of the lateral margin having detached from the inferior angle of the scapula and penetrating the thoracic cavity through the second intercostal space. Therefore, there existed the possibility of a pleural breach. We opted to perform an operation of open reduction and internal fixation via the Judet approach, during which it was confirmed that the fracture fragments were in contact but didn't perforate the pleura, thereby avoiding complications such as pneumothorax. The use of plates on both the medial and lateral columns, together with the sturdy scapular spine, formed a triangular structure that stabilized the fracture. At the six-month postoperative follow-up, the patient demonstrated favorable clinical outcomes.</p><p><strong>Conclusion: </strong>Surgical approaches are increasingly becoming minimally invasive. In this complex case of scapular fracture, we chose a sufficiently exposed large incision surgical approach to provide a clear view of the fracture fragment that was directed toward the pleura. The non-thoracotomy approach, avoiding the complication of pneumothorax and ensuring rigid fracture fixation, represented an alternative form of \"minimally invasive\" surgery.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"495"},"PeriodicalIF":2.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparation of the perioperative clinical characteristics during total hip arthroplasty of patients with rheumatoid arthritis and ankylosing spondylitis.","authors":"Jiangyu Nan, Hengxin Chen, Hu Qian, Ting Lei, Yihe Hu","doi":"10.1186/s12891-025-08752-3","DOIUrl":"10.1186/s12891-025-08752-3","url":null,"abstract":"<p><strong>Objective: </strong>Total hip arthroplasty (THA) has been applied as a successful treatment for repairing the impaired hip joints of patients with advanced inflammatory arthritis. Few studies compared the inpatient clinical characteristics of these patients receiving THA due to inflammatory arthritis. This study aims to compare the perioperative clinical outcome of patients receiving THA due to rheumatoid arthritis (RA) or ankylosing spondylitis (AS).</p><p><strong>Methods: </strong>We retrospectively included 60 patients receiving THA due to RA or AS, and compared their inpatient clinical characteristics. The collected data comprised baseline data including gender, age, body mass index (BMI), blood pressure, Barthel index and clinical outcomes including operative time, perioperative blood loss, perioperative inflammatory indicators, length of hospitalization, inpatient medicine cost and perioperative complications.</p><p><strong>Results: </strong>AS patients showed increased operative blood loss and autologous transfusion rate than the RA patients. In addition, RA patients showed increased serum level of erythrocyte sedimentation rate (ESR) and interleukin-6 (IL-6), while no significant difference was found between the two groups in length of hospitalization, medicine cost and perioperative complications.</p><p><strong>Conclusion: </strong>We suggested that more attention should be paid to the blood loss management of AS patients during perioperative stage, since AS patients were more susceptible to blood loss during THA with the potential reason to remove large amounts of osteophyte.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"496"},"PeriodicalIF":2.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: The link between osteoporosis and frozen shoulder: exploring the therapeutic effect of TAK715 on reversing fibrosis and protecting against osteoporosis via the p38 MAPK signaling pathway.","authors":"Xinhao Li, Yan Yan, Zhuo Wang, Jingyi Hou, Yuhan Meng, Dedong Cui, Yi Long, Ming Li, Rui Yang","doi":"10.1186/s12891-025-08662-4","DOIUrl":"10.1186/s12891-025-08662-4","url":null,"abstract":"","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"497"},"PeriodicalIF":2.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of arthroscopy combined with continuous irrigation, arthroscopic debridement alone, and open arthrotomy for the treatment of septic arthritis of the native knee.","authors":"Jie Xiao, WenTing Wu, Shun Lin, Yun Zheng, KaiFeng Lin, Tao You, QiPing Wu, Feng Shen, Xiu Yang, XueSong Han","doi":"10.1186/s12891-025-08724-7","DOIUrl":"10.1186/s12891-025-08724-7","url":null,"abstract":"<p><strong>Background: </strong>The optimal surgical treatment for septic arthritis of the knee remains debatable, with few studies comparing different arthroscopic techniques. Furthermore, no study has simultaneously compared arthroscopy combined with continuous irrigation, arthroscopic debridement alone, and open arthrotomy. This study compared the efficacy and success rates of these three surgical methods and analyzed the risk factors for failure following initial surgery.</p><p><strong>Methods: </strong>Data were collected from patients who underwent surgery for native knee septic arthritis at the 900th Hospital of Joint Logistic Support Force in China between 2013 and 2023. A retrospective comparison of demographics, comorbidities, auxiliary examination results, causes, microorganisms, and efficacy outcomes was made among the three surgical groups.</p><p><strong>Results: </strong>A total of 65 patients (65 knees) were included in the study. All three groups had similar baseline characteristics. Postoperative C-reactive protein levels recovered faster in the continuous irrigation group than in the open group (p < 0.001). Both arthroscopic procedures showed a lower rate of hemoglobin decrease compared with open arthrotomy (p = 0.005 for the continuous irrigation group vs. open group; p = 0.023 for the debridement alone group vs. open group). The initial surgical success rate was higher in the continuous irrigation group (93.3%) than in the open group (65.2%) (p = 0.025). After adjusting for confounding factors through multivariate analysis, this advantage remained, with the risk of initial surgical failure in the open group being 11.31 times that in the continuous irrigation group (odds ratio = 11.31, 95% confidence interval: 1.7-75.24, p = 0.012). No significant differences were observed in postoperative range of motion, pain, or functional scores among the three groups.</p><p><strong>Conclusion: </strong>No significant long-term functional differences were observed among the three surgical methods used to treat septic arthritis of the knee. The continuous irrigation group had an advantage in the early postoperative normalization of CRP levels and a higher initial surgical success rate than the open group.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"494"},"PeriodicalIF":2.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of clinical efficacy between Percutaneous Endoscopic Large channels nerve decompression through Translaminar approach and Percutaneous Endoscopy Conventional channels nerve decompression through Transforaminal approach for the treatment of degenerative L4/5 spinal stenosis: a retrospective study.","authors":"Junlin Liu, Qingquan Kong, Junsong Ma, Pin Feng, Bin Zhang","doi":"10.1186/s12891-025-08623-x","DOIUrl":"10.1186/s12891-025-08623-x","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objecytive: &lt;/strong&gt;Percutaneous endoscopic surgery via the interlaminar approach and transforaminal approach are commonly used for the treatment of degenerative lumbar spinal stenosis, and in order to compare the clinical efficacy of Percutaneous Endoscopic Large channel Translaminar approach (PEL-TL) and Percutaneous Endoscopy Conventional channels Transforaminal approach (PEC-TF) in the treatment of degenerative L4/5 spinal stenosis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Method: &lt;/strong&gt;A retrospective analysis was conducted on 124 patients who underwent percutaneous endoscopic single segment unilateral decompression surgery for degenerative L4/5 spinal stenosis in our hospital from January 2020 to January 2023. They were divided into PEL-TL group and PEC-TF group according to different surgical methods. Recording general information of two groups of patients, including age, gender, course of disease, and length of hospital stay. Recording the surgical time, C-arm fluoroscopy frequency, incidence and type of complications for two groups of patients. CT was used to measure the Lateral Recess Angle (LRA), and MRI was used to measure the Dural Sac Cross sectional Area (DSCA) to evaluate the degree of lateral recess stenosis and compare the neurological decompression between the two groups. Using the White Panjabi scoring system (WP) to evaluate local stability before and 3 months after surgery. Recording the Visual Analog Scale (VAS) and Oswestry Disability Index (ODI) for preoperative and postoperative hip and lower limb pain in two groups of patients. Evaluateing the efficacy using the modified Macnab criteria one year after surgery.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;There was no statistically significant difference in general information between the two groups of patients (P &gt; 0.05). The surgery time in the PEL-TL group was shorter than that in the PEC-TF group (P &lt; 0.05). The number of C-arm fluoroscopy in the PEL-TL group was significantly lower than that in the PEC-TF group (P &lt; 0.05). There was no statistically significant difference in the incidence of complications between the two groups of patients (11.1% in the PEL-TL group and 14.3% in the PEC-TF group) (P &gt; 0.05). The postoperative recurrence rate of PEL-TL is lower than that of PEC-TF (P &lt; 0.05). All enrolled patients were followed up regularly for 1 year. There was no significant difference in preoperative LRA and DSCA between the two groups of patients (P &gt; 0.05). After 1 year of surgery, LRA and DSCA in both groups were significantly larger than before (P &lt; 0.05). There was no statistically significant difference in postoperative DSCA between the two groups, but LRA in the PEL-TL group was more significantly larger than that in the PEC-TF group (P &lt; 0.05). There was no statistically significant difference in preoperative and postoperative WP between the two groups of patients, and there was no significant difference in WP in two groups. The ODI scores and the VAS scores of buttock and lower l","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"493"},"PeriodicalIF":2.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative computed tomography assessment of peri-hip muscles in patients with femoral neck fracture and its impact on postoperative walking function.","authors":"Katsuya Yokoyama, Taku Ukai, Makoto Ogawa, Masahiko Watanabe","doi":"10.1186/s12891-025-08668-y","DOIUrl":"10.1186/s12891-025-08668-y","url":null,"abstract":"<p><strong>Background: </strong>The role of preoperative peri-hip muscles in postoperative walking ability for patients with femoral neck fractures is unclear. This study investigated the influence of these muscles on postoperative walking function using computed tomography (CT).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 58 patients (12 male, 46 female) who underwent bipolar hemiarthroplasty for femoral neck fractures between January 2018 and July 2021. Patients were followed up for at least six months postoperatively and categorized into two groups: the independent walking group (41 patients) and the non-walking group (17 patients). Patient data, including sex, age at surgery, body mass index (BMI), and preoperative walking status, were compared. Additionally, preoperative CT scans assessed the cross-sectional areas and CT values of the gluteus medius, gluteus maximus, and rectus femoris muscles on the unaffected side. These measurements were compared between the two groups.</p><p><strong>Results: </strong>No significant differences were observed between the groups regarding sex, age, BMI, or preoperative walking status. The CT values of the gluteus medius and gluteus maximus were significantly lower in the non-walking group compared with the walking group (gluteus medius: 39.3 ± 7.5 Hounsfield units (HU) vs. 28.6 ± 6.9 HU; P < 0.01; gluteus maximus: 33.0 ± 8.1 HU vs. 23.3 ± 10.7 HU; P < 0.01), whereas no significant differences were found for the rectus femoris. Cross-sectional areas of all muscles did not show significant differences between the two groups. Receiver operating characteristic curve analysis revealed that the gluteus medius had an area under the curve (AUC) of 0.86, with a sensitivity of 0.78 and specificity of 0.82, using a cut-off of 33.1 HU. The gluteus maximus had an AUC of 0.77, with a sensitivity of 0.63 and specificity of 0.77, using a cut-off of 31.6 HU.</p><p><strong>Conclusions: </strong>Preoperative CT values of the gluteus medius and gluteus maximus were lower in the non-walking group, suggesting that these muscles influence postoperative walking ability. Preoperative CT evaluation of these muscles can be a useful predictor of postoperative walking outcomes.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"490"},"PeriodicalIF":2.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of customized orthoses on foot morphology and pressure in patients with accessory navicular syndrome.","authors":"Xiaopeng Pu, Wenwen Xing, Zishen Cheng, Yantao Wang, Yuqing Wang, Yaxing Zhang, Liangliang Jiang, Bin Liu, Qiangjun Kang","doi":"10.1186/s12891-025-08689-7","DOIUrl":"10.1186/s12891-025-08689-7","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the effects of customized orthoses on foot morphology and plantar pressure in professional athletes with accessory navicular syndrome (ANS) over a 12-month period, compared to conventional insoles.</p><p><strong>Methods: </strong>In this randomized controlled study, 54 pro athletes with medial foot pain, diagnosed with ANS, joined after 3-month training. Split into two groups: custom orthotics (intervention) or regular insoles (control). Evaluated at 3, 6, 12 months on foot structure (arch, navicular, etc.) and function (pressure, force-time integral, VAS pain). Found significant improvements in intervention group's foot shape, pressure distribution, and pain reduction compared to controls.</p><p><strong>Results: </strong>Compared to the control group, the intervention group showed significant increases in arch angle and arch height across all assessment intervals (P < 0.05). Additionally, heel eversion angle and navicular prominence distance significantly decreased in the intervention group compared to controls (P < 0.05). Pressure and force-time integral values at the first metatarsal head, medial arch, and medial heel significantly decreased, while lateral arch loading increased in the intervention group (P < 0.05). VAS scores for foot pain significantly decreased in the intervention group compared to controls (P < 0.05).</p><p><strong>Conclusion: </strong>Customized orthoses effectively improved foot morphology and reduced plantar pressure in professional athletes with ANS compared to conventional insoles. These findings suggest that customized orthotic intervention provides faster and more significant pain relief for patients with ANS-related medial arch collapse.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Registry (ChiCTR2500100238; Retrospectively registered on 04/07/2025).</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"491"},"PeriodicalIF":2.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing low femoral neck BMD in Qatar Biobank participants using machine learning models.","authors":"Nedhal Al-Husaini, Rozaimi Razali, Amal Al-Haidose, Mohammed Al-Hamdani, Atiyeh M Abdallah","doi":"10.1186/s12891-025-08726-5","DOIUrl":"10.1186/s12891-025-08726-5","url":null,"abstract":"<p><strong>Background: </strong>Identifying determinants of low bone mineral density (BMD) is crucial for understanding the underlying pathobiology and developing effective prevention and management strategies. Here we applied machine learning (ML) algorithms to predict low femoral neck BMD using standard demographic and laboratory parameters.</p><p><strong>Methods: </strong>Data from 4829 healthy individuals enrolled in the Qatar Biobank were studied. The cohort was split 60% and 40% for training and validation, respectively. Logistic regression algorithms were implemented to predict femoral neck BMD, and the area under the curve (AUC) was used to evaluate model performance. Features associated with low femoral neck BMD were subjected the statistical analysis to establish associated risk.</p><p><strong>Results: </strong>The final predictive model had an AUC of 86.4% (accuracy 79%, 95%CI: 77.98-80.65%) for the training set and 85.9% (accuracy 78%, 95% CI: 75.92-80.61%) for the validation set. Sex, body mass index, age, creatinine, alkaline phosphatase, total cholesterol, and magnesium were identified as informative features for predicting femoral neck BMD. Age (odds ratio (OR) 0.945, 95%CI: 0.945-0.963, p < 0.001), alkaline phosphatase (OR 0.990, 95%CI: 0.986-0.995, p < 0.001), total cholesterol (OR 0.845, 95%CI: 0.767-0.931, p < 0.001), and magnesium (OR 0.136, 95%CI: 0.034-0.571, p < 0.001) were inversely associated with BMD, while BMI and creatinine were positively associated with BMD (OR 1.116, 95%CI: 1.140-1.192, p < 0.001 and OR 1.031, 95%CI: 1.022-1.039, p < 0.001, respectively).</p><p><strong>Conclusion: </strong>Several biological determinants were found to have a significant global effect on BMD with a reasonable effect size. By combining standard demographic and laboratory variables, our model provides proof-of-concept for predicting low BMD. This approach suggests that, with further validation, an ML-driven model could complement or potentially reduce the need for imaging when assessing individuals at risk for low BMD, which is an important component of fracture risk prediction.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"492"},"PeriodicalIF":2.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare cause for osteonecrosis of femoral head and peripheral nerve damage of a child with depression.","authors":"Ke Wang, Yun Chen, Hao Zhou","doi":"10.1186/s12891-025-08682-0","DOIUrl":"10.1186/s12891-025-08682-0","url":null,"abstract":"<p><strong>Background: </strong>Avascular necrosis of the femoral head (ANFH) that is due to the use of carbamazepine (CBZ) in children whose condition requires long-term oral CBZ is relatively rare, and there are no clinical reports on this topic. Herein, we present a rare case of femoral head necrosis and peripheral nerve damage due to long-term use of CBZ in a child with depression.</p><p><strong>Patient presentation: </strong>A 12-year-old boy who was taking oral CBZ for depression presented to the hospital with a sudden onset of impaired consciousness. On admission, the blood CBZ concentration was 32.6 µg/mL, an electromyogram (EMG) revealed severe partial injury to the left common peroneal and tibial nerves, and magnetic resonance imaging (MRI) of the hip revealed necrosis of the left femoral head. On predischarge evaluation, the CBZ blood level was < 0.2 µg/mL. The long-term use of CBZ is thought to have resulted in femoral head necrosis and peripheral nerve damage.</p><p><strong>Conclusions: </strong>To our knowledge, this is the first literature report of femoral head necrosis with peripheral nerve damage due to long-term CBZ use. For patients receiving long-term treatment with CBZ, careful monitoring for osteoarthritis, bone pain, and decreased sensation and range of motion of the extremities, as well as detailed medical history-taking and complete imaging, electromyography, and neurosonography of the hip joint, are needed.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"485"},"PeriodicalIF":2.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-fat diet-induced osteoporosis in mice under hypoxic conditions.","authors":"Yajun Qiao, Huimin Zheng, Ruiying Cheng, Juan Guo, Li Ji, Zhibin Liu, Lixin Wei, Hongtao Bi, Zhongshu Shan","doi":"10.1186/s12891-025-08725-6","DOIUrl":"10.1186/s12891-025-08725-6","url":null,"abstract":"<p><p>In the context of global aging, osteoporosis has emerged as a significant public health concern, with a relatively high prevalence observed in plateau regions. This study aimed to investigate the effects and underlying mechanisms of high-fat diet (HFD) and hypoxic conditions on bone metabolism in mice. The mice were subjected to different dietary regimens (a HFD versus a normal diet) and placed in a hypoxic environment. This study explored relevant mechanisms through comprehensive assessments, including body and bone morphological indices, pathological examinations, biochemical analyses, evaluation of gut microbiota diversity, and metabolomics approaches. The results indicated that, compared with those in the control group, the body weight, Lee's index, body mass index (BMI), and body fat percentage of the HFD-fed group were significantly greater. Additionally, the femoral microstructure was compromised, bone metabolic markers were disrupted, inflammatory responses were heightened, gut microbiota diversity was altered, and specific intestinal metabolites such as Anserine were downregulated, whereas L-carnosine was upregulated. Spearman correlation analysis and network visualization elucidated the multifactorial influence mechanism of a HFD on bone metabolism under hypoxic conditions. These factors interconnect to form a complex network that drives osteoporosis development. Notably, L-carnosine occupies a central position within this network, serving as a key hub for interactions among various factors. Under the dual stressors of hypoxia and a HFD, this network becomes imbalanced, leading to bone metabolic disorders and osteoporosis. This study provides insights into the multifactorial mechanisms of osteoporosis induced by a HFD and hypoxia in mice, offering a foundation for subsequent research and preventive strategies for osteoporosis in plateau areas.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"487"},"PeriodicalIF":2.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}