BMC Musculoskeletal Disorders最新文献

{"title":"Construction and evaluation of a prognostic model based on the expression of the metabolism-related signatures in patients with osteosarcoma.","authors":"Tieli Wu, Xingyi Wu","doi":"10.1186/s12891-025-08439-9","DOIUrl":"10.1186/s12891-025-08439-9","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to screen three major substance metabolism-related genes and establish a prognostic model for osteosarcoma.</p><p><strong>Methods: </strong>RNA-seq expression data for osteosarcoma were downloaded from The Cancer Genome Atlas (TCGA) and GEO databases. Differentially expressed (DE) RNAs were selected, followed by the selection of metabolic-related DE mRNAs. Using Cox regression analysis, prognostic DE RNAs were identified to construct a prognostic model. Subsequently, independent prognostic clinical factors were screened, and the functions of the long non-coding RNAs (lncRNAs) were analyzed. Finally, the expression of signature genes was further tested in osteosarcoma cells using quantitative reverse transcription quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting.</p><p><strong>Results: </strong>A total of 432 DE RNAs, comprising 79 DE lncRNAs and 353 DE mRNAs were obtained, and then 107 metabolic-related DE mRNAs. Afterwards signature genes (LINC00545, LINC01537, FOXC2-AS1, CYP27B1, PFKFB4, PHKG1, PHYKPL, PXMP2, and XYLB) served as optimal combinations, and a prognostic score model was successfully proposed. Three verification datasets (GSE16091, GSE21257, and GSE39055) showed that the model had high specificity and sensitivity. In addition, two independent prognostic clinical factors (age and tumor metastasis) were identified. Finally, the concordance rate between the in silico analysis, qRT-PCR, and western blotting analysis was 88.89% (8/9), suggesting the robustness of our analysis.</p><p><strong>Conclusions: </strong>The prognostic model based on the nine signature genes accurately predicted the prognosis of patients with osteosarcoma; CYP27B1, PFKFB4, PHKG1, PHYKPL, PXMP2, and XYLB may serve as metabolism-related biomarkers in osteosarcoma.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"303"},"PeriodicalIF":2.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finite element analysis of the stability of tibiofibular fractures treated with various combinations of external fixators.","authors":"Xubiao Ye, Jinling Luo, Pu Chen, Xiaohua Wei, Shifeng Liu","doi":"10.1186/s12891-025-08530-1","DOIUrl":"10.1186/s12891-025-08530-1","url":null,"abstract":"<p><strong>Background: </strong>External fixators have been extensively applied in the treatment of open tibiofibular fractures and have yielded positive outcomes. The stability of an external fixator primarily hinges on its structure. Employing additional external fixation components can undoubtedly enhance stability. However, there is scant research on the topic of achieving superior stability with fewer external fixation components.</p><p><strong>Methods: </strong>Utilizing 3D modeling software, constructed three different external fixation models in middle tibial fractures in Group A, constructed four external fixation models in proximal tibial fractures in Group B, and constructed four external fixation models in distal tibial fractures in Group C.Simulate the load under the assistance of a walker to stand up, obtain the displacement of fractures and the stress of the external fixator for each group. Analyze and compare the results of each model.</p><p><strong>Results: </strong>In a mid-tibial fracture, the stability of the crossbar increases by 21% with each 2 cm closer to the tibia. Model B3 achieves superior stability with the use of more fixed clamps and connecting rods in the \"H\" shaped model. Although the triangular cross-bar structure used in Model B4 is less stable than that of Model B3, it has achieved 83.2% of the stability of Model B3, despite using fewer components. The stability of Model C4 has increased by 73.44% compared to Model C3.</p><p><strong>Conclusions: </strong>The external fixator should be configured to keep the crossbar as close to the skin as possible. For proximal tibial fractures, to minimize the use of external fixation components, the triangular cross-bar structure of Model B4 can be employed. In the case of distal tibial fractures, while the triangular cross-bar structure of Model C4 offers good stability, the risk of displacement is greater. Therefore, it is advisable to use an H-shaped fixation method with additional external fixation components, such as those found in Model C3.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"304"},"PeriodicalIF":2.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How do different standing positions affect trunk muscle activation in LBP-developers during prolonged standing?","authors":"Saeedeh Abbasi, Hooman Minoonejad, Hamed Abbasi, Seyed Hamed Mousavi","doi":"10.1186/s12891-025-08525-y","DOIUrl":"10.1186/s12891-025-08525-y","url":null,"abstract":"<p><strong>Background: </strong>Low back pain developers (PDs) are individuals at a high risk of developing low back pain (LBP), especially during prolonged standing. Understanding their characteristics is essential for devising effective preventive strategies. Prolonged standing has been associated with increased co-contraction of trunk muscles and elevated activity of the trunk extensor muscles. This study aims to examine the effects of using a normalized footrest height and altering arm positions on muscle activity in PDs.</p><p><strong>Methods: </strong>Twenty-four female PDs, identified by a > 10 mm increase on the visual analog scale (VAS) during prolonged standing, were recruited. They were randomly divided into two groups: Group A used a footrest intermittently, while Group B used a footrest combined with changes in arm positions (shoulder flexion and hands crossed on the clavicles). Muscle activity was monitored using electromyography (EMG) over a one-hour standing protocol.</p><p><strong>Results: </strong>Both interventions significantly reduced lumbar erector spinae (LES) muscle activity, as well as co-contraction of the trunk flexor and extensor muscles (p < 0.05). The group that adjusted their arm positions (Group B) experienced a greater reduction in muscle activity (p = 0.05). Additionally, transversus abdominis (TrA) muscle activity slightly increased in both groups, with a more notable increase in Group B (p > 0.05). Although lumbar spine muscle activity decreased, thoracic spine extensor (TES) activity increased in Group B. This increase is attributed to the engagement of the thoracic spine during upper limb movement, compensating for the reduced lumbar muscle activity, which may help alleviate back pain.</p><p><strong>Conclusions: </strong>Using footrests cyclically and adjusting arm positions can help prevent back pain during prolonged standing by promoting muscle relaxation, reducing fatigue, and improving posture. These findings offer practical strategies for enhancing workplace ergonomics, particularly for occupations involving prolonged standing.</p><p><strong>Trial registration: </strong>This study is registered in the Clinical Trial Registry ( http://www.irct.ir/ ) with Trial ID 71,648 and IRCT ID IRCT20230628058610N1, dated January 20, 2024.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"299"},"PeriodicalIF":2.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is screw position a greater contributor to adjacent segment disease than plate-to-disc distance following anterior cervical discectomy and fusion?","authors":"Feng Wang, Jiawei Lu, Bijun Wang, Ziqi Zhu, Beiduo Shen, Kai Guo, Zhaoyu Ba, Yufeng Huang, Desheng Wu","doi":"10.1186/s12891-025-08285-9","DOIUrl":"10.1186/s12891-025-08285-9","url":null,"abstract":"<p><strong>Background: </strong>To investigate the risk factors for radiographic adjacent segment disease (RASD), with a focus on the impact of screw position, following anterior cervical discectomy and fusion with plate fixation (ACDF-P).</p><p><strong>Methods: </strong>We conducted a comprehensive analysis on 126 patients who underwent ACDF-P for degenerative cervical spinal disease, evaluating various factors such as demographics, cervical sagittal parameters, the number of fused segments, sagittal screw angle, plate to disc distance (PDD), and screw position score (SPS). Based on MRI findings, we classified patients into ASD and Non-ASD groups. Logistic regression analysis was used to evaluate risk factors, and the model's discrimination was assessed using the receiver operating characteristic (ROC) curve. Additionally, we evaluated the predictive value of SPS for RASD using ROC curves. To further investigate the relationship between screw position and RASD, we reanalyzed the data of patients with PDD of less than 5 mm to eliminate the effect of PDD.</p><p><strong>Results: </strong>Among the 126 patients, 57 developed RASD after a minimum follow-up period of 5 years. No significant differences were observed in demographics, cervical sagittal parameters, number of fused segments, or sagittal screw angle between the two groups (p > 0.05). However, PDD and SPS showed significant differences between the two groups (p < 0.05). Multivariate binary logistic models revealed that PDD (OR: 3.238; 95% CI:1.191-8.807; p < 0.021) and SPS (OR: 1.309 95% CI: 1.092-1.568; p = 0.004) were risk factor for RASD. The models exhibited excellent discrimination and calibration. The area under the curve (AUC) for RASD identified by SPS were 0.674. Among patients with PDD less than 5 mm, SPS was significantly higher in the ASD group compared to the Non-ASD group (p < 0.05). After grouping by screw position, it was determined that both the incidence of RASD (70.5% vs. 34.6%, p < 0.05) and the percentage of long-segment fusion (3-4 levels) (38.6% vs. 7.7%, p < 0.05) were significantly higher in the group with a score greater than 6 compared to the group with a score of 6 or lower.</p><p><strong>Conclusions: </strong>Our findings indicate that a PDD of less than 5 mm and a higher SPS are related with RASD following ACDF-P. Secondary analysis indicates that screw position, as indicated by the SPS, may be a primary contributor to ASD, rather than PDD.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"297"},"PeriodicalIF":2.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between estimated glucose disposal rate and osteoarthritis risk in US adults: a cross-sectional study.","authors":"Zhiqiang Que, Dingqiang Chen, Huirong Cai, Weibin Lan, Yuxuan Huang, Gang Rui","doi":"10.1186/s12891-025-08568-1","DOIUrl":"10.1186/s12891-025-08568-1","url":null,"abstract":"<p><strong>Background: </strong>Estimated glucose disposal rate (eGDR) is a novel insulin resistance (IR) assessment surrogate. Although it has shown promising potential in other metabolic disease studies, no research has yet explored its relationship with osteoarthritis (OA). Therefore, this study aims to investigate the association between eGDR and OA in a cross-sectional observational cohort.</p><p><strong>Method: </strong>Data utilized in this cross-sectional study were drawn from the National Health and Nutrition Examination Survey (NHANES). Logistic regression models were used to evaluate the association between eGDR and OA, stratified analysis was applied to assess the stability of the results.</p><p><strong>Result: </strong>A total of 19,040 participants were included in the study, including 2,001 OA patients and 17,039 non-OA participants with an age distribution ranging from 20 to 85 years. The fully adjusted logistic regression model shows that eGDR were less likely associated with OA compared to those with non-OA (OR = 0.879, 95% CI = 0.846-0.914, P < 0.001). By dispersing the eGDR into quartiles, the correlation between eGDR and OA remained significant (P for trend < 0.0001).</p><p><strong>Conclusion: </strong>This study suggests that eGDR is independently associated with OA, with lower eGDR values being linked to a higher risk of OA.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"302"},"PeriodicalIF":2.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between serum insulin level and low muscle mass in older individuals: evidence from the China Health and Nutrition Survey.","authors":"Guofang Sun, Jianjun Liang, Dechao Chen, Kongjun Zhao, Wangmi Liu","doi":"10.1186/s12891-025-08542-x","DOIUrl":"10.1186/s12891-025-08542-x","url":null,"abstract":"<p><strong>Background: </strong>The link between serum insulin level and low muscle mass among older adults is not yet fully understood. This study seeks to investigate this association using data from a nationally representative large-scale survey.</p><p><strong>Methods: </strong>The study utilized data from two waves of the China Health and Nutrition Survey (CHNS) conducted in 2009 and 2015. Subjects meeting the inclusion criteria were classified according to the Asia Working Group for Sarcopenia 2019 criteria. The study employed ordinary least squares (OLS) regression models to analyze the cross-sectional association between appendicular skeletal muscle mass (ASM) and serum insulin level. Additionally, based on the median insulin level in the population without low muscle mass in 2009, these individuals were divided into high insulin and low insulin groups. Logistic regression models were utilized to examine the longitudinal association between low muscle mass and serum insulin level.</p><p><strong>Results: </strong>In 2009, a cross-sectional association study enrolled a total of 2329 participants aged over 60 years, with 53.1% women and a median age of 68.00 years. The prevalence of low muscle mass in the study population was 30.83%, with females accounting for 60.03%. In the adjusted OLS regression model based on blood biomarker, serum insulin level was positively associated with ASM (β = 0.075, 95% confidence interval (95% CI): 0.034-0.117, P < 0.01). A total of 944 individuals from the 2009 population without low muscle mass were divided into high insulin and low insulin groups based on the median insulin level, and were followed up until 2015. It was found that there was a significant difference in the incidence of low muscle mass between the two groups. (12.44% vs. 7.45%, P = 0.01). The adjusted logistic regression models indicated that higher serum insulin levels were associated with a reduced incidence of low muscle mass (Hazard ratio = 0.958, 95% CI: 0.925-0.989, P = 0.01).</p><p><strong>Conclusions: </strong>Adequate serum insulin level could potentially serve as a protective factor in preserving healthy muscle mass among Chinese adults aged 60 and above.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"300"},"PeriodicalIF":2.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the clinical outcomes and radiological parameters between the greater tuberosity strengthened proximal humeral plate and the proximal humeral internal locking system plate in the minimally invasive plate osteosynthesis treatment of proximal humeral fractures involving the greater tuberosity: a retrospective cohort study.","authors":"Jiadi Le, Jianpeng Lu, Jianxiong Zhang, Zhenghao Wu, Long Chen","doi":"10.1186/s12891-025-08543-w","DOIUrl":"10.1186/s12891-025-08543-w","url":null,"abstract":"<p><strong>Background: </strong>With the gradual promotion of minimally invasive plate osteosynthesis (MIPO) in the treatment of proximal humeral fractures, some patients using the proximal humeral internal locking system (PHILOS) plate experience significant displacement of the fixed greater tuberosity. However, this is rarely seen in patients using a new plate named the greater tuberosity strengthened proximal humeral plate (GTSPHP). Notably, a comparison of these two plates is lacking. Therefore, we aimed to retrospectively compare the clinical outcomes and radiological parameters of MIPO using the GTSPHP and PHILOS plates.</p><p><strong>Methods: </strong>The data of 40 patients with proximal humeral fractures involving the greater tuberosity who underwent MIPO performed by the same physician between 1 April 2019 and 31 December 2022 were retrospectively analysed. Sixteen and 24 patients were included in the GTSPHP and PHILOS plate groups, respectively and followed up for at least 1 year postoperatively. General clinical characteristics, perioperative data, postoperative follow-up clinical outcomes, complications, and reduction loss of the greater tuberosity were compared between the two groups.</p><p><strong>Results: </strong>No significant differences were found in age, sex, affected side, injury mechanism, fracture type, injury to surgery time, operative time, postoperative hospital stay, the shortened version of the Disabilities of the Arm, Shoulder, and Hand questionnaire (QuickDASH) score, and Constant score between the two groups. However, the GTSPHP group was superior to the PHILOS plate group regarding surgical incision length, intraoperative blood loss, and the 11-point numerical rating scale score on the first, second and third postoperative days. In the PHILOS plate group, three patients had fracture malunion; both groups showed no signs of incision infection, fracture non-union, screw cut-out, or subacromial impingement syndrome. Both groups showed no significant differences in complication rates. The risk of reduction loss of greater tuberosity was lower in the GTSPHP group than in the PHILOS plate group.</p><p><strong>Conclusions: </strong>Our study showed that in MIPO treatment of proximal humeral fractures involving the greater tuberosity, the GTSPHP outperformed the PHILOS plate in terms of intraoperative blood loss, surgical incision length, short-term postoperative pain, and fixation capability of the greater tuberosity. However, further research is needed to confirm these findings.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"301"},"PeriodicalIF":2.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the quality of care for knee osteoarthritis in Singapore: a cross-sectional study.","authors":"Ren Hao Linus Tan, Anthony J Goff, Chien Joo Lim, Yijia Bryan Tan","doi":"10.1186/s12891-025-08524-z","DOIUrl":"10.1186/s12891-025-08524-z","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to assess the self-reported quality of care for people with knee osteoarthritis in Singapore and to investigate the associations between participant characteristics and functional outcomes at 1 year in relation to the reported quality of care.</p><p><strong>Methods: </strong>Patients with knee osteoarthritis completed the osteoarthritis quality indicator (OA-QI) questionnaire, a validated patient-reported measure that assesses the clinician's adherence to evidence-based guidelines for non-surgical knee osteoarthritis education and patient education. The OA-QI includes 17 indicators, with \"achievement\" defined as a 'Yes' response for each. We calculated individual per-item, overall per-item mean, and per-person achievement rates (%) and examined associations between participant characteristics, achievement rates, and function at 1 year.</p><p><strong>Results: </strong>A total of 314 participants completed the OA-QI. Referral for physical activity (87.5%) and referral for daily activity aid assessment (15.7%) had the highest and lowest per-item achievement rates, respectively. The overall mean per-item and per-person achievement rates were both 62.2%. Participants educated about steroid injections (adjusted coefficient [95% CI]: 7.23 [1.42-13.04]; p = 0.015) or surgery (adjusted coefficient [95% CI]: 12.65 [5.89-19.40]; p < 0.001) had worse functional outcomes at one year than those who were eligible but not informed. Those not assessed for walking aids and indicating walking issues had poorer outcomes one year later (adjusted coefficient [95% CI]: -9.89 (-19.63, -0.15); p = 0.0470). However, no significant associations were found between per-person achievement rates and 1-year functional outcomes.</p><p><strong>Conclusions: </strong>The quality of care in Singapore for people with knee osteoarthritis is suboptimal, especially for those needing walking aids and weight loss assistance. However, the quality of care alone does not fully account for long-term outcomes, suggesting that other factors need to be considered.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"298"},"PeriodicalIF":2.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy analysis of extrapedicular unilateral percutaneous vertebroplasty via the upper edge of the transverse process for lumbar osteoporotic vertebral compression fractures.","authors":"Junru Zheng, Haopeng Luan, Ying He, Lei Hong, Pengyuan Han, Xiaonan Wang, Xing Wang, Qiaojuan Wang, Qisong Shang","doi":"10.1186/s12891-025-08534-x","DOIUrl":"10.1186/s12891-025-08534-x","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical effect of vertebroplasty through unilateral upper edge of transverse process in the treatment of lumbar osteoporotic vertebral compression fracture (OVCF), and to explore the surgical indications and operation points of this technique.</p><p><strong>Methods: </strong>Ninety patients with osteoporotic vertebral compression fractures of the lumbar spine treated in our hospital from June 2020 to June 2021 were retrospectively analyzed and divided into the experimental group and the control group for vertebroplasty according to the principle of randomization; the experimental group was treated with a lateral pedicle approach through the upper edge of the unilateral transverse process, and the control group was treated with a unilateral pedicle approach. After more than 1 year of follow-up, the operation time, intraoperative fluoroscopy times, bone cement injection volume, Oswestry disability index (ODI), Visual analogue scale (VAS) were compared between the two groups to assess the functional recovery of the patients.</p><p><strong>Results: </strong>There was no significant difference in the general data (age, gender, location and number of fractured vertebral bodies, and follow-up time) between the two groups before surgery. In the experimental group, there were 42 OVCF patients (15 males and 27 females), and the operated segments were L1 vertebral body in 17 cases, L2 vertebral body in 13 cases, L3 vertebral body in 8 cases, L4 vertebral body in 3 cases, and L5 vertebral body in 1 case. The control group consisted of 48 OVCF patients (16 males and 32 females), and the operated segments were L1 vertebral body in 21 cases, L2 vertebral body in 15 cases, L3 vertebral body in 8 cases, L4 vertebral body in 2 cases, and L5 vertebral body in 2 cases. In terms of operation time and intraoperative fluoroscopy times, the experimental group was less than the control group, and the difference had statistical significance (P < 0.05); in terms of bone cement injection volume, the difference between the two groups had no statistical significance (P > 0.05); in terms of pain VAS score and dysfunction index ODI score, the scores of the two groups were improved with the extension of follow-up time compared with those before surgery, but the difference between the two groups had no statistical significance (P > 0.05).</p><p><strong>Conclusion: </strong>Compared with the traditional approach, PVP via the unilateral extrapedicular approach at the upper edge of the transverse process has the advantages of less operation time and fluoroscopy times, uniform diffusion of bone cement, and is comparable to the traditional surgical approach in relieving pain and improving patient function, but due to the limitation of the length of the puncture needle, careful operation is required during the operation.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"293"},"PeriodicalIF":2.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A reflexive thematic analysis of existential losses in men with osteoporosis: \"I'm not the person I was somehow … although I am\".","authors":"Francine Toye, Karen Louise Barker, Sarah Drew, Tanzeela Y Khalid, Emma M Clark","doi":"10.1186/s12891-025-08486-2","DOIUrl":"10.1186/s12891-025-08486-2","url":null,"abstract":"<p><strong>Background: </strong>Osteoporosis is a global health concern that is likely to increase with a rapidly ageing world population. It affects one in three women and one in five men over the age of 50. Although there is a large body of qualitative research exploring the experience of living with osteoporosis, far fewer studies have focused on men. We aimed to explore the experiences of men with osteoporotic vertebral fracture.</p><p><strong>Methods: </strong>We interviewed 13 White British men aged 63 to 94 with an osteoporotic vertebral fracture. We used the six stages of reflexive thematic analysis: familiarisation with the data; coding; generating initial themes; developing and reviewing themes through discussion; refining and naming themes; writing up.</p><p><strong>Results: </strong>We developed six themes giving insight into the existential losses of men with osteoporosis: I have felt a step change coming; I regret that I am no longer the person I once was; it is demeaning (but others are worse off than me); I need to know where I am heading; I need to understand why me; I need to feel like I am in someone's hands. We describe moral narratives used in defence of self.</p><p><strong>Conclusions: </strong>Our findings highlight the challenge of deciphering the symptoms of osteoporosis and age-related changes. We also see the impact on self and a struggle to repair self. Healthcare providers are in a unique and privileged position to accompany their patients at points of existential crisis. As such, they attend to the repair of both identity and body. This comes with an ethical responsibility and has implications for clinical education. Health professionals should feel equipped to be alongside people facing existential losses. Qualitative research can give valuable insight into the phenomenology of illness and contribute to improvements in care pathways.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"294"},"PeriodicalIF":2.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}