BMC Musculoskeletal Disorders最新文献

{"title":"Experimental study on the biomechanical loading of a four-dimensional plate for the fixation of femoral shaft fractures.","authors":"Meiling Song, Jian Wen, Zhe Wang, Yu Zeng, Jun Lu, Wei Lu, Changsheng Chen, Xieping Dong","doi":"10.1186/s12891-025-08756-z","DOIUrl":"10.1186/s12891-025-08756-z","url":null,"abstract":"<p><strong>Objective: </strong>To explore the biomechanical properties of a four-dimensional structure locking osteosynthesis plate that can alter its structure and functionality over time.</p><p><strong>Methods: </strong>According to the AO classification (AO-A2) standard, 18 artificial femoral shaft oblique fracture models with the same position and shape were generated and subsequently randomly divided into 2 groups (n = 9). In the experimental group, the four-dimensional locking plate was fixed, and in the control group, the locking plate was fixed. In vitro loading experiments were carried out under three conditions: 1400 N axial compression, 500 N internal and external four-point bending, and 15 N·m torsion. The average compression stiffness, average bending stiffness, average torsional stiffness, and displacement were compared between the two groups.</p><p><strong>Results: </strong>Under vertical loading, the average compression stiffness of the experimental group (558.7 ± 39.1) N/mm was greater than that of the control group (548.8 ± 24.5) N/mm, (P = 0.73); and the average displacement of the fracture end of the experimental group (3.3 ± 0.2) mm was lower than that of the control group (3.4 ± 0.3) mm, (P = 0.47). The differences were not statistically significant. Under four-point bending loading, the average bending stiffness of the experimental group (466.6 ± 85.8) N/mm was lower than that of the control group (542.5 ± 43.2) N/mm, and the difference was not statistically significant (P = 0.24). The average displacement of the fracture ends in the experimental group (1.6 ± 0.2)mm was greater than that in the control group (1.2 ± 0.1)mm, and the difference was statistically significant (P = 0.02). Under torsional loading, the average torsional stiffness of the experimental group (1.0 ± 0.1) N·m/deg was lower than that of the control group (1.1 ± 0.1) N·m/deg, (P = 0.27); and the average angular displacement of the fracture end of the experimental group (15.9 ± 1.3) deg was greater than that of the control group (14.6 ± 1.3) deg, (P = 0.26). There was no significant difference between the two groups.</p><p><strong>Conclusion: </strong>The anti-compression, anti-bending and anti-torsion properties of four-dimensional locking plates are similar to those of conventional locking plates and can meet the mechanical requirements of internal fracture fixation.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"535"},"PeriodicalIF":2.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computer-simulated mirror osteotomy in the treatment of post-traumatic cubitus varus deformity in children.","authors":"WenQiang Xu, YongFei Fan, XiuLin Ma, JianQiang Zhang, WenZhi Bi, ChaoYu Liu, Wei Wang","doi":"10.1186/s12891-025-08795-6","DOIUrl":"10.1186/s12891-025-08795-6","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;To explore the feasibility and early clinical efficacy of computer-based mirroring technology in simulating osteotomy for the treatment of post-traumatic cubitus varus deformity in children.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective analysis was conducted on the data of 26 patients with cubitus varus deformity who were admitted between June 2019 and June 2024. Among them, there were 19 males and 7 females, with an average age of 8.12 ± 2.83 years (ranging from 5 to 15 years). The time from injury to surgery ranged from 13 to 84 months, averaging at 27.85 ± 21.91 months. The carrying angle and anteversion measured on full-length anteroposterior radiographs of both upper extremities and lateral radiographs of the elbow joint were used as osteotomy parameters. Low-dose CT scans of both upper extremities of the pediatric patients were performed to reconstruct three-dimensional (3D) models of the affected limb for computer-simulated osteotomy. The 3D mirror-imaging technique of the unaffected side was applied for overlay comparison, and the osteotomy parameters were adjusted accordingly. Surgeries were performed based on the final parameters obtained. Intraoperative data such as surgical duration and blood loss were recorded, and regular postoperative follow-ups were conducted with X-ray examinations to observe bone callus formation in the osteotomy area. At the final follow-up, the carrying angle, anteversion, and range of motion (flexion and extension) of the elbow joints on both the affected and unaffected sides were measured, and elbow function was assessed using the Mayo score.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The surgical duration for the 26 patients ranged from 35 to 55 min, averaging at 44.23 ± 7.83 min, with an average blood loss of 32.12 ± 6.35 ml (ranging from 20 to 40 ml). The mean follow-up duration was 31.12 ± 15.81 months (ranging from 6 to 60 months). Kirschner wires (K-wires) were removed 8-12 weeks postoperatively, and plates were taken out 4-6 months later. During the follow-up period, two patients experienced pin tract irritation symptoms after K-wire fixation, which improved after dressing changes; one patient had poor plate adherence causing skin irritation and recovered after early removal of the internal fixation. No complications such as fracture or loosening of the internal fixation devices occurred. At the final follow-up, the carrying angle of the affected elbow joint was (13.48 ± 4.19) °, the anteversion was (44.08 ± 3.80) °, the flexion was (143.27 ± 1.51) °, and the extension was (-7.23 ± 1.63) °. These values were significantly improved compared to those before surgery and showed no significant difference compared to the unaffected side. According to the Mayo Elbow Performance Score, 24 patients were rated as excellent and 2 as good.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Using computer-based mirroring technology for osteotomy simulation enables precise bone resection, which not only shorte","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"537"},"PeriodicalIF":2.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular clues in joint degeneration: a cross-sectional study on the association between aortic knob width, aortic arch calcification, and the severity of hand and knee osteoarthritis.","authors":"Yakup Erden, Mustafa Sağlam, Mustafa Hüseyin Temel","doi":"10.1186/s12891-025-08774-x","DOIUrl":"10.1186/s12891-025-08774-x","url":null,"abstract":"","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"534"},"PeriodicalIF":2.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of patellofemoral instability by quantitative ultrasound elastography device: a feasibility study.","authors":"Lan Zeng, Li Zhang, Jiuyi Ma, Jianqiu Huang, Yang Sun","doi":"10.1186/s12891-025-08778-7","DOIUrl":"10.1186/s12891-025-08778-7","url":null,"abstract":"<p><strong>Background: </strong>This study evaluated the reproducibility of shear modulus (SM) measurements of the quadriceps muscle in straight and bent knee positions using a quantitative ultrasound elastography device and explored its potential in predicting patellofemoral instability (PFI).</p><p><strong>Methods: </strong>The study included 13 healthy subjects and 34 patients with anterior knee pain. Among the 68 legs of 34 patients, 23 had lateral patellar tilt and 9 had patella alta. The SM of the lateral femoral muscle (LFM), medial femoral muscle (MFM), and rectus femoris muscle (RFM) was measured in both knee straight and bent positions using a quantitative ultrasound device. Intra-observer and inter-observer reliability were assessed by intraclass correlation coefficient (ICC), and the performance of SM values in predicting lateral patellar tilt and patella alta was analyzed using receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>SM measurements of the LFM, MFM, and RFM showed good to excellent intra- and inter-observer reliability (ICC = 0.770-0.993, all P < 0.001). The group with lateral patellar tilt showed significantly higher SM(LFM)_bent, SM(L/M)_bent, and SM(LFM)_{bent-straight} compared to the group without lateral patellar tilt. Similarly, SM(RFM)_bent and SM(RFM)_{bent-straight} of the group with patella alta were significantly higher than those of the group without patella alta. ROC analysis showed that SM(LFM)_bent and SM(LFM)_{bent-straight} were highly effective in predicting lateral patellar tilt, while SM(RFM)_bent and SM(RFM)_{bent-straight} were effective for predicting patella alta.</p><p><strong>Conclusions: </strong>Quantitative elastography ultrasound for measuring quadriceps muscle SM offers a reliable, noninvasive method for assessing mechanical stress around the knee, providing high predictive accuracy for PFI.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"532"},"PeriodicalIF":2.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wnt/β-catenin regulates Gli1 + osteogenic progenitors in condylar subchondral bone development and osteoarthritis.","authors":"Jie Wang, Lin Sun, Yi Zhang, Shuo Chen, Yang He","doi":"10.1186/s12891-025-08765-y","DOIUrl":"10.1186/s12891-025-08765-y","url":null,"abstract":"<p><strong>Background: </strong>Gli1 has been identified as a marker of osteogenic progenitors in the condylar subchondral bone. The Wnt/β-catenin signaling pathway is known to regulate stem cell proliferation and differentiation in bone. Whether Wnt/β-catenin signaling pathway could influence Gli1 + osteogenic progenitors remains unclear. Here, we aimed to investigate the role and related mechanisms of Wnt/β-catenin signaling in the regulation of Gli1 + osteogenic progenitors in condylar development and temporomandibular joint osteoarthritis (TMJOA).</p><p><strong>Methods: </strong>We generated Gli1-Cre^ERT2;tdTomato mice to perform lineage tracing; We generated Gli1-Cre^ERT2; β-catenin^fl/fl mice, in which β-catenin was lost in the Gli1 + lineage to examine the role of Wnt/β-catenin signaling pathway in regulating the proliferation and differentiation of Gli1 + cells. The β-catenin CKO mice and their wild-type (WT) littermates were induced at 3 days and were euthanized 1, 2 or 4 weeks after induction; We induced a TMJOA model through a unilateral partial discectomy (UPD) of the temporomandibular joint disc in 6-week-old tamoxifen-treated Gli1-Cre^ERT2;β-catenin^fl/fl;tdTomato mice and control group (Gli1-Cre^ERT2;tdTomato mice). We harvested the mandibles at 4 weeks post-surgery.</p><p><strong>Results: </strong>Conditional knockout of β-catenin inhibited the osteogenic activity of Gli1 + progenitor cells during condylar subchondral bone development. In discectomy-induced TMJOA, the overactivation of Gli1 in subchondral bone drove pathological osteogenesis and aberrant subchondral bone remodeling. Deletion of β-catenin in Gli1 + cells mitigated excessive Gli1 + cells activation and ectopic mineralization.</p><p><strong>Conclusion: </strong>Our findings establish Wnt/β-catenin signaling as a key regulator of Gli1 + progenitor cell fate determination in both bone development and TMJOA pathogenesis.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"533"},"PeriodicalIF":2.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between systemic Immune-inflammation index, systemic inflammation response index and adult osteoarthritis: national health and nutrition examination survey.","authors":"Xiao-Jun Chen, Shu-Fen Liao, Qiu-Yi Ouyang, Ping Wang, Gui-Lan Huang, Shu-Yan Zeng, Qin Guo, Jin-Yan Li, Yang-Xi Shen, Na Li, Liu-Fang Huang, Feng-Qiu Gong","doi":"10.1186/s12891-025-08792-9","DOIUrl":"10.1186/s12891-025-08792-9","url":null,"abstract":"<p><strong>Background: </strong>Osteoarthritis (OA) is a degenerative and inflammatory joint disease caused by multiple factors, the underlying mechanisms of which are not fully understood. The systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) are both novel biomarkers and predictors of inflammation. Thus, this study aimed to evaluate the relationship between SII, SIRI and OA in adult.</p><p><strong>Objective: </strong>The ultimate goal is to gain a deeper understanding of how SII, SIRI influences OA and the implications of this relationship.</p><p><strong>Materials and methods: </strong>We analyzed data from 7204 participants aged 20 and older from the NHANES surveys conducted in 1999-2020, all of whom provided comprehensive data for this study. Standardized surveys assessed the presence of osteoarthritis and SII, SIRI. To thoroughly understand their relationship, we employed statistical techniques including multivariable logistic regression, stratified analysis with interaction, restricted cubic splines (RCS), and threshold effect analysis.</p><p><strong>Results: </strong>A total of 7204 adult participants were enrolled, composing of 2830 (39.3%) male and 4374 (60.7%) female with a median age of 62.2 ± 13.9 years, 2955 (41.0%) were diagnosed with OA. Accordingly, A linear relationship between SII and OA was discovered after adjusting for underlying confounders, (p > 0.05) in RCS, and the association between the SIRI and OA exhibited a nonlinear relationship (p = 0. 042) in RCS. In the threshold analysis, the OR of developing OA was 1.648 (95% CI: 1.144 ~ 2.374, p < 0.05) in participants with SIRI of < 0.99 10³ cells/ml. There was no significantly association between the SIRI and OA when the SIRI was ≥ 0.99 10³ cells/ml. Further sensitivity analyses provided confidence that the results are robust and not likely to be substantially influenced by unmeasured confounding factors.</p><p><strong>Conclusions: </strong>This cross-sectional study demonstrated that a linear relationship between SII and OA, and the association between the SIRI and OA was found to be nonlinear.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"529"},"PeriodicalIF":2.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between cardiovascular health and osteoarthritis in middle-aged and elderly U.S. population: a cross-sectional NHANES study.","authors":"Dui Mou, Yuhang Liu, Siyao Gao, Peng Zhao","doi":"10.1186/s12891-025-08781-y","DOIUrl":"10.1186/s12891-025-08781-y","url":null,"abstract":"","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"528"},"PeriodicalIF":2.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative cross-sectional study of optimal screw positioning in the talus during arthroscopic ankle arthrodesis: a computed tomography-based analysis of talar bone density.","authors":"Satoshi Kamijo, Tsukasa Kumai, Yasuhito Tanaka","doi":"10.1186/s12891-025-08798-3","DOIUrl":"10.1186/s12891-025-08798-3","url":null,"abstract":"<p><strong>Background: </strong>To achieve successful osteosynthesis during arthroscopic ankle arthrodesis, increased stability and compression pressure during fixation are needed. Screw threads must be anchored within the talus, however, the bone mineral density of the talus has not been reported. This study used computed tomographic values to determine whether bone mineral density of the talus is lower in patients with ankle osteoarthritis than in healthy individuals and to determine the part of the talar cancellous bone with the highest bone mineral density.</p><p><strong>Methods: </strong>We studied the talus in 10 feet with and 10 without end-stage ankle osteoarthritis. Each talar cancellous bone was divided into the lateral process, head and neck, middle body, and medial body. Computed tomographic values of each segment were measured to calculate the relative bone mineral density difference between regions.</p><p><strong>Results: </strong>Mean (± standard deviations) computed tomographic values in the healthy talus group were 638.329 ± 139.765, 465.960 ± 74.254, 537.109 ± 82.443, and 469.016 ± 84.490 for the four segments. Mean computed tomographic values in the end-stage ankle osteoarthritis talus group were 360.994 ± 117.403, 284.397 ± 101.142, 327.814 ± 114.772, and 297.524 ± 105.667 for the same segments. The bone mineral density of the lateral process of the talus was significantly higher in both the healthy and osteoarthritis talus groups, and the bone mineral density of the talus in the osteoarthritis talus group was significantly lower than that in the healthy talus group.</p><p><strong>Conclusions: </strong>The bone mineral density of the talus in end-stage ankle osteoarthritis was significantly lower than that of a healthy talus. The highest relative bone mineral density was inferred to be from the middle body to the lateral process.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"530"},"PeriodicalIF":2.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical properties of extrinsic foot muscles, Achilles tendon, and plantar fascia in patients with a history of diabetic foot ulcers.","authors":"Fatmagül Varol, Ali Ilez, Yavuz Aslan","doi":"10.1186/s12891-025-08791-w","DOIUrl":"10.1186/s12891-025-08791-w","url":null,"abstract":"<p><strong>Background: </strong>Diabetic foot ulcers (DFU) are a major complication of diabetes, often leading to impaired mobility and increased risk of recurrence due to persistent biomechanical alterations. Understanding the mechanical properties of foot muscles, tendons, and fascia may provide insight into ulcer development, prevention and rehabilitation strategies. This study aimed to assess the biomechanical properties of the extrinsic foot muscles, Achilles tendon (AT), and plantar fascia (PF) in individuals with a history of DFU using myotonometry.</p><p><strong>Methods: </strong>A total of 38 diabetic feet with a history of DFU (Wagner Grade 0-1) and 40 healthy controls (HC) were evaluated. The MyotonPRO device was used to measure muscle tone (Natural Oscillation Frequency, F), stiffness, and elasticity in the tibialis anterior (TA), gastrocnemius medialis (GM), gastrocnemius lateralis (GL), AT, and PF. Measurements were performed in standardized positions, with statistical comparisons made between groups using independent t-tests.</p><p><strong>Results: </strong>TA and GM showed significantly increased muscle tone and stiffness in the DFU group compared to HC (p < 0.05), whereas GL did not exhibit significant differences. Similarly, PF and AT stiffness were higher in the DFU group (p < 0.05), suggesting alterations in tissue load distribution. No significant differences in elasticity were observed between groups.</p><p><strong>Conclusions: </strong>This study highlights persistent mechanical alterations in the TA, GM, AT, and PF in individuals with a history of DFU, despite ulcer healing. The increased stiffness and tone in these structures may contribute to abnormal foot loading patterns, potentially increasing the risk of ulcer recurrence. The findings emphasize the importance of early biomechanical assessment and targeted rehabilitation strategies, such as neuromuscular training, load redistribution, Achilles tendon stretching and custom orthotic interventions to mitigate mechanical dysfunction in diabetic foot patients.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"531"},"PeriodicalIF":2.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral biportal endoscopic lumbar interbody fusion (ULIF) versus minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) for the treatment of degenerative lumbar spondylolisthesis: a retrospective analysis.","authors":"Zhicheng Zhu, Banglin He, Jifu Sun, Liqun Lin, Chen Meng, Yan Sun, Chao Jiang, Yonghui Huang","doi":"10.1186/s12891-025-08777-8","DOIUrl":"10.1186/s12891-025-08777-8","url":null,"abstract":"<p><strong>Objective: </strong>This study retrospectively compared the early clinical and imaging outcomes of the single-level Meyerding Grade I degenerative lumbar spondylolisthesis (DLS) between unilateral biportal endoscopic lumbar interbody fusion (ULIF) and minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) using an expandable tubular retractor system under a surgical loupe.</p><p><strong>Methods: </strong>This was a retrospective study. This study included fifty-five patients, with twenty-eight underwent ULIF and twenty-seven who underwent MI-TLIF at the Affiliated Hospital of Jiangsu University from June 2020 to July 2021. Demographic characteristic, surgical parameters, laboratory results, and clinical and imaging outcomes were collected and compared between the two groups.</p><p><strong>Results: </strong>In our retrospective study, the ULIF group was superior in terms of the mean total blood loss, intraoperative blood loss than MI-TLIF (P < 0.05). However, there was no statistically significant difference in hidden blood loss between the two groups (P > 0.05). Moreover, the mean operative time was significantly longer than in the ULIF group in the MI-TLIF group (P < 0.05). The mean CK and CRP levels on the first postoperative day were significantly lower in the ULIF group (P < 0.001). All clinical scores improved significantly after the operation in both groups. The VAS back score for pain at two weeks and 1 month postoperatively was significantly lower in the ULIF group (P < 0.05). There was no significant difference between the two groups in the change in the dural sac cross-sectional area preoperatively or at the final postoperative follow-up. The fusion rate was significantly greater in ULIF at 6 months after the operation (P < 0.05).</p><p><strong>Conclusion: </strong>Compared to MI-TLIF, the ULIF technique has the advantages of less hemorrhage, less inflammation, and earlier fusion. However, this approach has a limited operation time. However, further clinical outcomes need to be followed up in the longer term.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"526"},"PeriodicalIF":2.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}