BMC Musculoskeletal Disorders最新文献

{"title":"Investigation of the efficiency of pulsed electromagnetic field treatment and stretching exercise in experimental skeletal muscle injury model.","authors":"Mesut Ergan, Tahir Keskіn, İbrahim Aydın Candan, Yalçın Erzurumlu, Halil Aşci, Selçuk Çömlekçı, Ferdi Başkurt","doi":"10.1186/s12891-025-08442-0","DOIUrl":"10.1186/s12891-025-08442-0","url":null,"abstract":"<p><strong>Objective: </strong>Pulsed electromagnetic fields (PEMF) and stretching exercises are safe and noninvasive methods that could have a therapeutic effect on tissue healing. This study aimed to assess the effectiveness of these methods in treatment of muscle injury (INJ).</p><p><strong>Method: </strong>Rats were divided into 5 groups (Control, INJ, INJ + Exercise, INJ + PEMF, INJ + Exercise + PEMF). At the end of the experiment, genetic, histopathological, and immunohistochemical evaluations were made in the muscle tissue.</p><p><strong>Results: </strong>Mononuclear cell infiltration, muscle degeneration, atrophy, and necrosis were found to be higher in the INJ group than in all groups (p < 0.001). On the 7th day, fibroblast growth factor (FGF) was found to be higher in the INJ group compared to both the control and the INJ + Exercise group (p < 0.05). On the 14th day, Vascular endothelial growth factor values were found to be higher in the injury group than the other groups except for the PEMF group (p < 0.05), and FGF values were higher in the injury group compared to all groups (p < 0.001). The expressions of transforming growth factor beta 1 (TGF-β1) and endothelial nitric oxide synthase (eNOS) on the 7th and 14th days showed a significant increase in the INJ group compared to the other groups (p < 0.001).</p><p><strong>Conclusion: </strong>In this study, it has been shown that PEMF and stretching exercise is effective in the treatment of muscle injuries as they balance the inflammatory process in the muscle, have a positive effect on muscle development, accelerate healing, prevent fibrosis development by reducing TGF-β1 signaling, and inhibit inflammatory-induced eNOS activity.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"289"},"PeriodicalIF":2.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To scan or not to scan? Comparing the effectiveness and cost differential of insoles manufactured from foam-box casts versus direct scans in treating musculoskeletal conditions of the foot and ankle: a double-blinded, randomised controlled trial.","authors":"Laura Barr, Jim Richards, Colette Dickson, Jillian Tawse, Nikki Munro, Hannah Scott, Aimie Holland, Graham J Chapman","doi":"10.1186/s12891-025-08513-2","DOIUrl":"10.1186/s12891-025-08513-2","url":null,"abstract":"<p><strong>Background: </strong>Foot orthoses produced using computer-aided-design and manufacture (CAD/CAM) are commonly used to treat musculoskeletal conditions of the foot and ankle, however minimal evidence exists as to the most effective method used to capture the patients foot shape. This trial aimed to determine the effectiveness and cost of insoles manufactured from a direct scan of the foot compared with those manufactured from foam-box casts.</p><p><strong>Methods: </strong>This double blinded clinical trial randomly assigned participants with lower limb musculoskeletal pathologies into two groups and provided them with custom CAD/CAM foot orthoses manufactured either from a direct scan of the participants' feet (direct scan group) or from foam-box casts of their feet (foam-box cast group). 114 participants were recruited and asked to wear their foot orthoses for 12-weeks. The Foot Health Status Questionnaire (FHSQ) was completed at baseline, 4, 8 and 12-weeks to evaluate the primary outcome measure of pain, as well as secondary outcomes for foot function, foot health and footwear, and the Orthotic and Prosthetic User Survey Client Satisfaction with Device module (OPUS-CSD) was completed at 12-weeks. Adherence was measured using a daily wear-diary recorded over 12-weeks. The number of manual insole adaptations was also recorded, and staff time, material and transportation costs were evaluated.</p><p><strong>Results: </strong>112 participants completed the trial. Despite no significant between-group differences, both groups reported significant improvements in pain, function and foot health from baseline to 4, 8 and 12-weeks, which all exceeded their respective minimum important differences. The direct scan group reported greater satisfaction at 12-weeks (p = 0.04), greater adherence (p < 0.001), and required less insole adaptations (n = 4) compared to the foam-box cast group (n = 15) (p = 0.006). Overall costs and staff time costs were higher in the foam-box cast group.</p><p><strong>Conclusions: </strong>CAD/CAM insoles are effective in reducing pain, and improving foot function and foot health after 4-weeks, and sustained at 12-weeks, however the method of shape capture does not affect these responses. Over 12-weeks participant satisfaction and adherence was greater when using the direct scan approach, which also required fewer manual insole adaptations. There was a greater overall cost associated with foam-box insoles. Clinicians are therefore recommended to use direct foot scanning over foam-box casting when prescribing CAD/CAM insoles for patients with musculoskeletal foot and ankle conditions.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov, trial number NCT05444192. Trial registration date 30th June 2022.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"282"},"PeriodicalIF":2.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondria derived from Stem cells modulated the biological behavior of monocyte-macrophages and inhibited inflammatory bone resorption.","authors":"Xingfu Li, Jingyue Su, Xiang Liu, Wei Lu, Zhenhan Deng","doi":"10.1186/s12891-025-08529-8","DOIUrl":"10.1186/s12891-025-08529-8","url":null,"abstract":"<p><strong>Background: </strong>The transfer of mitochondria from stem cells effectively attenuates the viability of inflammatory cells. However, there is a paucity of research supporting the inhibitory effect of stem cells on inflammatory bone resorption through mitochondrial transfer.</p><p><strong>Methods: </strong>Mouse bone resorption models were established to investigate the impact of stem cell-derived mitochondria. Stem cells, stem cell-derived mitochondria and exosomes were injected into the animal models for experimental research. Healthy mice and mice with bone resorption were included as the control groups. The mitochondrial transfer and bone resorption of mice calvaria were evaluated by immunofluorescence, gross morphology, micro-computed tomography (micro-CT), immunohistochemical staining. Monocyte-macrophages were incubated with stem cell-derived mitochondria as experimental group. Monocyte-macrophages and activated monocyte-macrophages cultured separately served as the control groups. The mitochondrial transfer and biological behavior of monocyte-macrophages were evaluated by immunofluorescence, enzyme-linked immunosorbent assay (ELISA), Multiskan FC, and histochemical staining.</p><p><strong>Results: </strong>Stem cell-derived mitochondria were successfully transferred to monocyte-macrophages. In vivo, local injection of stem cells, mitochondria, and exosomes effectively mitigated inflammatory cell infiltration, suppressed osteoclast maturation, and demonstrated a higher relative bone volume in mouse bone resorption models compared to the negative control group. In vitro, the co-incubation of mitochondria effectively suppressed the secretion of inflammatory cytokines, proliferation, fusion, and osteoclastogenesis in monocyte-macrophages compared to the control groups.</p><p><strong>Conclusions: </strong>The modulation of monocyte-macrophages biological behaviors by stem cells may occur through the transfer of mitochondria, thereby mitigating inflammatory bone resorption.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"286"},"PeriodicalIF":2.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive factors of distal pedicle screw loosening followed posterior corrective surgery for degenerative lumbar scoliosis.","authors":"Hongru Yuan, Yilei Liu, Chenjie Dai, Puxin Yang, Yachong Huo, Di Zhang, Hui Wang","doi":"10.1186/s12891-025-08519-w","DOIUrl":"10.1186/s12891-025-08519-w","url":null,"abstract":"<p><strong>Introduction: </strong>To explore incidence and predictive factors for distal pedicle screw loosening (DPSL) followed posterior corrective surgery for degenerative lumbar scoliosis (DLS).</p><p><strong>Methods: </strong>The diagnostic criteria for DPSL developed by X-ray including radiolucent area around screw and \"double halo\" sign. According to occurrence of DPSL at two-year follow-up, 153 patients were divided into two groups: study group (screw loosening) and control group (without screw loosening). To investigate predictive factors for DPSL, three categorized factors including general data, surgical data and radiological data were analyzed statistically.</p><p><strong>Results: </strong>DPSL was detected in 72 patients at two-year follow up (study group). Hounsfield unit (HU) value was lower in study group than that in control group. Fusion level was longer in study group than that in control group. Lower instrumented vertebrae on L5 was less in study group than that in control group. Posterolateral fusion was less in study group than that in control group. Preoperative Cobb angle, postoperative Cobb angle, Cobb angle correction, preoperative lumbosacral coronal angle (LSCA), LSCA correction, preoperative thoracolumbar junction (TL), postoperative TL were larger in study group than those in control group. Logistic regression analysis revealed that low Bone mineral density (BMD) (< 169 HU), posterolateral fusion, Cobb angle correction (> 16 degrees), LSCA correction (> 9 degrees) were independently associated with DPSL.</p><p><strong>Conclusions: </strong>The incidence of DPSL following posterior decompression and instrumented fusion for DLS is 47.1%. Low BMD, large correction of both main curve and fractional curve are predictive factors for DPSL, posterolateral fusion is a protective factor.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"283"},"PeriodicalIF":2.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-based radiomics using MRI to differentiate early-stage Duchenne and Becker muscular dystrophy in children.","authors":"Taiya Chen, Haoran Zhu, Yingyi Hu, Yang Huang, Wengan He, Yizhen Luo, Zeqi Wu, Diangang Fang, Longwei Sun, Hongwu Zeng, Zhiyong Li","doi":"10.1186/s12891-025-08538-7","DOIUrl":"10.1186/s12891-025-08538-7","url":null,"abstract":"<p><strong>Objectives: </strong>Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) present similar symptoms in the early stage, complicating their differentiation. This study aims to develop a classification model using radiomic features from MRI T2-weighted Dixon sequences to increase the accuracy of distinguishing DMD and BMD in the early disease stage.</p><p><strong>Methods: </strong>We retrospectively analysed MRI data from 62 patients aged 36-60 months with muscular dystrophy, including 41 with DMD and 21 with BMD. Radiomic features were extracted from in-phase, opposed-phase, water, fat, and postprocessed fat fraction images. We employed a deep learning segmentation method to segment regions of interest automatically. Feature selection included the Mann‒Whitney U test for identifying significant features, Pearson correlation analysis to remove collinear features, and the LASSO regression method to select features with nonzero coefficients. These selected features were then used in various machine learning algorithms to construct the classification model, and their diagnostic performance was compared.</p><p><strong>Results: </strong>Our proposed radiomic and machine learning methods effectively distinguished early DMD and BMD. The machine learning models significantly outperformed the radiologists in terms of accuracy (81.2-90.6% compared with 69.4%), specificity (71.0-86.0% compared with 19.0%), and F1 score (85.2-92.6% compared with 80.5%), while maintaining relatively high sensitivity (85.6-95.0% compared with 95.1%).</p><p><strong>Conclusion: </strong>Radiomics based on Dixon sequences combined with machine learning methods can effectively distinguish between DMD and BMD in the early stages, providing a new and effective tool for the early diagnosis of these muscular dystrophies.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"287"},"PeriodicalIF":2.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Femoral inherent torsion is more accurate than femoral anteversion angle in evaluating femoral torsion to determine whether combine derotational distal femoral osteotomy or not.","authors":"Zhengyi Ni, Kehan Li, Xiaobo Chen, Yitong Hu, Jingting Zhang, Fei Wang","doi":"10.1186/s12891-025-08522-1","DOIUrl":"10.1186/s12891-025-08522-1","url":null,"abstract":"<p><strong>Background: </strong>Previous view is that femoral anteversion angle (FAA) is equivalent to femoral torsion (FT) and as an indication for derotational distal femoral osteotomy (DDFO) combined with medial patellofemoral ligament reconstruction (MPFLR), but posterior femoral condylar deformity affects FAA. Therefore, FAA is not accurate in assessing FT. Whether the femoral inherent torsion (FIT), which avoids the influence of the posterior condyle, can better reflect FT during surgery remains unknown. Meanwhile, the impact of the posterior femoral condyle on surgical outcomes remains unclear.</p><p><strong>Methods: </strong>Twenty-five patellar dislocation (PD) patients from 2017 to 2021 were conducted. All patients underwent both preoperative and postoperative computed tomography scans. Categorized by posterior condylar angle (PCA), they were divided into Group A (PCA ≤ 6.4°) and Group B (PCA > 6.4°). Radiographic measurements included FAA, femoral inherent torsion (FIT), patellar tilt angle, congruence angle and tibial tubercle-trochlear groove distance. For clinical outcomes, the Kujula score, Lysholm score, IKDC score to reflect the knee function. The Tegner activity score was used to assess the activity level. The VAS score was used to assess the pain control.</p><p><strong>Results: </strong>In both groups, the postoperative radiographic outcomes demonstrated a statistically significant improvement. Preoperatively, the FAA was similar in the two groups, but the FIT was greater in the Group A (21.7° ± 1.2° vs 18.4° ± 1 .3°, P < 0.001). However, there was no statistically significant difference between them in the postoperative period (7.4° ± 1.5° vs 7.1° ± 1.8°). In terms of clinical outcomes, both groups demonstrated a significant improvement in the postoperative period. However, the scores of the Group A significantly better (Kujula: 85.7 ± 5.0 vs 79.6 ± 4.8, P = 0.005; Lysholm: 86.8 ± 5.3 vs 80.2 ± 5.7, P = 0.006; IKDC: 86.1 ± 8.8 vs 75.5 ± 7.6, P = 0.004).</p><p><strong>Conclusion: </strong>FIT may be a more reliable indicator than FAA for evaluating FT in PD to determine whether combine DDFO or not, especially in the presence of posterior femoral condylar deformity. Posterior femoral condylar deformity appeared to result in a pseudo-increase in FAA. Simultaneous evaluation of FIT and FAA to identify true posterior condylar deformity offers the potential to prevent enlargement of DDFO and enable precision treatment.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"284"},"PeriodicalIF":2.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent diffuse tenosynovial giant cell tumor of the posterior knee: a rare presentation with synovial herniation (Baker's cyst) in a young patient.","authors":"Khalid AlHarbi, Sultan AlHussain","doi":"10.1186/s12891-025-08511-4","DOIUrl":"10.1186/s12891-025-08511-4","url":null,"abstract":"<p><strong>Introduction: </strong>Tenosynovial giant cell tumor (TGCT), previously referred to as pigmented villonodular synovitis (PVNS), is a rare, locally aggressive proliferative disorder of the synovium. It typically affects large joints, most commonly the knee. Posterior compartment involvement in the knee is less common compared to anterior or suprapatellar involvement, and it presents unique diagnostic and therapeutic challenges due to the complex anatomy and proximity to neurovascular structures. While popliteal (Baker's) cysts may coexist with intra-articular TGCT, they are considered synovial herniation cysts rather than true extra-articular involvement, which can be associated with diagnostic and therapeutic challenges.</p><p><strong>Case presentation: </strong>This case report describes a 24-year-old male with recurrent diffuse TGCT of the knee, predominantly involving the posterior compartment, along with a large Baker's cyst and synovial thickening adjacent to the medial femoral condyle. Magnetic resonance imaging (MRI) revealed extensive synovial proliferation with characteristic low T2 signal intensity, confirming the diagnosis and guiding surgical planning. The patient underwent arthroscopic-assisted synovectomy to address both the suprapatellar and posterior compartments while preserving critical neurovascular structures. Postoperatively, the patient had improved knee function and was referred for adjuvant therapy to minimize recurrence risk.</p><p><strong>Conclusion: </strong>This case highlights the importance of accurate imaging, meticulous surgical planning, and a multidisciplinary approach in managing rare presentations of TGCT. Long-term follow-up and consideration of adjuvant therapies such as radiotherapy or systemic therapies, including Pexidartinib, remain essential to minimize recurrence and optimize outcomes.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"281"},"PeriodicalIF":2.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatics and machine learning approaches to explore key biomarkers in muscle aging linked to adipogenesis.","authors":"Yumin Zhang, Li Qin, Juan Liu","doi":"10.1186/s12891-025-08528-9","DOIUrl":"10.1186/s12891-025-08528-9","url":null,"abstract":"<p><p>Adipogenesis is intricately linked to the onset and progression of muscle aging; however, the relevant biomarkers remain unclear. This study sought to identify key genes associated with adipogenesis in the context of muscle aging. Firstly, gene expression profiles from biopsies of the vastus lateralis muscle in both young and elderly population were retrieved from the GEO database. After intersecting with the results of differential gene analysis, weighted gene co-expression network analysis, and sets of adipogenesis-related genes, 29 adipogenesis-related differential expressed genes (ARDEGs) were selected. Connectivity Map (cMAP) analysis identified tamsulosin, fraxidin, and alaproclate as key target compounds. In further, using three machine learning algorithms and the friends analysis, four hub ARDEGs, ESRRA, RXRG, GADD45A, and CEBPB were identified and verified in vivo aged mice muscles. Immune infiltration analysis showed a strong link between several immune cells and hub ARDEGs. In all, these findings suggested that ESRRA, RXRG, GADD45A, and CEBPB could serve as adipogenesis related biomarkers in muscle aging.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"285"},"PeriodicalIF":2.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arthroscopic Bankart repair using trans-glenoid double-loaded grand knots versus double-loaded suture anchors; is there a difference? a randomized controlled study.","authors":"Amr Samir Rashwan, Al-Qassem Amin, Sherif Hamdy Zawam, Alaa Mohy-Eldin Soliman, Mahmoud El-Desouky","doi":"10.1186/s12891-025-08477-3","DOIUrl":"10.1186/s12891-025-08477-3","url":null,"abstract":"<p><strong>Background: </strong>Anatomical repair of Bankart lesions and restoring the tension of the antero-inferior capsulo-labral complex is the optimum method of surgical treatment with a variety of fixation methods including suture anchors and trans-glenoid sutures. Grand knot technique is a modification of the trans-glenoid sutures technique that can be an alternative to double-loaded suture anchors with a lower cost. We aimed to compare the outcomes and complications of both techniques.</p><p><strong>Methods: </strong>This is a randomized controlled study that was conducted on 200 patients with recurrent anterior glenohumeral dislocation, of whom 170 patients completed at least a three-year follow-up period. Arthroscopic Bankart repair using two double-loaded knotted suture anchors was performed in 78 cases (Group A) while repair was done using two trans-glenoid grand knots in other 92 cases (Group B). Patients were evaluated in terms of range of motion, functional scores (Constant, Rowe, and ASES), and complication rate.</p><p><strong>Results: </strong>The mean operative time was significantly longer in Group B (87.7 ± 24) minutes compared to Group A (61.2 ± 28.1) minutes (P = 0.002). No statistically significant difference was found between both groups regarding postoperative external rotation range of adducted arm, functional scores, and rate of recurrence. Only forward flexion and external rotation of abducted arm were significantly better in Group A (P = 0.005 and < 0.001 respectively).</p><p><strong>Conclusion: </strong>Trans-glenoid double-loaded grand knot technique is an alternative surgical option for the treatment of Bankart lesions with comparable results to double-loaded anchors regarding the functional outcomes and failure rates.</p><p><strong>Clinical trial registration (retrospectively registered): </strong>Registration number: NCT06394609 28-4-2024.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"280"},"PeriodicalIF":2.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the clinical efficacy of patellar lateral retraction and patellar eversion in total knee arthroplasty: a systematic review and meta-analysis.","authors":"Mingjie Dong, Xiaoyu Sun, Hao Fan, Weiping Ren, Yushan Wang, Yingjie Gao, Pengfei Shao, Yu Gao, Qiang Jiao, Yi Feng","doi":"10.1186/s12891-025-08532-z","DOIUrl":"10.1186/s12891-025-08532-z","url":null,"abstract":"<p><strong>Background: </strong>According to the mobilization technique of the intraoperative patella, total knee arthroplasty (TKA) can be categorized into patellar eversion (PE) and patellar lateral retraction (PLR). Comparisons between the two procedures are inconclusive; therefore, the study purpose was to assess the postoperative clinical efficacy to identify the most suitable procedure.</p><p><strong>Methods: </strong>Electronic databases were searched, including Web of Science, ScienceDirect, PubMed, Embase, OVID, the Cochrane Library, CINAHL, CNKI, and WANFANG, to identify clinical trials of PLR versus PE from inception to May 2023. The statistical software Stata 15.0 and Review Manager 5.4 were applied to the data analysis.</p><p><strong>Results: </strong>Fifteen studies evaluating a total of 1349 patients and 1409 knees were ultimately included. Statistically significant differences emerged between the PLR and PE groups with respect to blood loss (P = 0.02), incision length (P < 0.001), operation time (P = 0.01), straight leg raise (P < 0.001), knee range of motion (ROM; P < 0.05), the Knee Society Score (KSS) functional score (P = 0.0003), the visual analogue scale (VAS) score (1 and 3 months, both P < 0.05), and operative complications (P = 0.02). Furthermore, the PLR and PE groups had similar clinical efficacy in terms of quadriceps strength, VAS score (1 week and 1 year), Hospital for Special Surgery score, KSS pain score, Insall-Salvati ratio, and the occurrence of patella baja (all P ≥ 0.05).</p><p><strong>Conclusions: </strong>The PLR procedure is superior to PE in terms of blood loss, incision length, straight leg raise, knee ROM, VAS score (1 and 3 months), KSS functional score, and operative complications, although PE could decrease the operation time. PLR could achieve better postoperative clinical outcomes than could PE. Therefore, it is recommended that experienced surgeons prioritize PLR in TKA.</p><p><strong>Registration: </strong>This study was registered in the PROSPERO international registry (Registration ID: CRD42023440722).</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"279"},"PeriodicalIF":2.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}