BMC Musculoskeletal Disorders最新文献

{"title":"Implant-free loop tenodesis compared to arthroscopic anchor tenodesis for the treatment of long head of biceps tendon disorders (LOOPTEN trial): study protocol for a multi-center non-inferiority randomized controlled trial.","authors":"Leopold Henssler, Florian Zeman, Doruk Akgün, Kathi Thiele, Stephan Pauly, Stefan Greiner, Andreas Voss, Christian Gerhardt, Lars-Johannes Lehmann, Gunnar Huppertz, Magdalena Elsner, Volker Alt, Michael Koller, Maximilian Kerschbaum","doi":"10.1186/s12891-025-08818-2","DOIUrl":"10.1186/s12891-025-08818-2","url":null,"abstract":"<p><strong>Background: </strong>Pathologies of the long head of the biceps (LHB) tendon are frequently seen as concomitant pathologies during arthroscopic surgery for rotator cuff injuries or the labroligamentous complex of the shoulder. Currently, there are two treatment options: Tenotomy is quick and easy to perform with low complications rates, but has limited functional results, especially in demanding patients; tenodesis of the tendon has shown beneficial cosmetic and functional results, but usually requires an implant for tendon-to-bone attachment and, therefore, carries the risk of implant-related complications. The implant-free loop tenodesis (LT) procedure was developed to combine the advantages of both treatment modalities and has shown promising functional and cosmetic results in a prospective pilot study. This study aims to establish the implant-free LT procedure versus arthroscopic anchor tenodesis (AAT) for the treatment of LHB pathologies during shoulder arthroscopy in terms of structural and functional outcome.</p><p><strong>Methods: </strong>A national multi-center, two-arm, parallel-group, randomized, controlled, non-inferiority trial will be conducted. Patients are eligible for trial participation if they are at least 18 years of age and present to one of the five enrolling centers with LHB tendon-associated complaints and MRI-confirmed LHB tendinopathy, instability due to SLAP or pulley lesions, or partial rupture. Patients with current or previous shoulder injury that would interfere with post-treatment rehabilitation or study assessment will be excluded from study participation. Participating patients will be randomized 1:1 to receive either LT or AAT and will be followed up for 24 months after surgery. The primary endpoint will be the functional and cosmetic outcome as assessed by the biceps-specific LHB score at 12 months after surgery. Secondary outcomes include assessment of surgery-related complications, overall shoulder and arm function, and structural outcome as evaluated by ultrasound and an additional MRI scan at the final study visit.</p><p><strong>Discussion: </strong>The study will evaluate whether the implant-free loop tenodesis procedure is non-inferior to arthroscopic implant-based tenodesis in terms of functional and cosmetic results at 12 months post-treatment.</p><p><strong>Trial registration: </strong>Trial was prospectively registered at the German Clinical Trials Register (DRKS) on 12^th June 2024, Registration-ID DRKS00034361, https://drks.de/search/de/trial/DRKS00034361 .</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"567"},"PeriodicalIF":2.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ideal pin length and interval in tension band wiring using ring pins for transverse olecranon fractures: a biomechanical study.","authors":"Seung Hoo Lee, Young Ho Lee","doi":"10.1186/s12891-025-08828-0","DOIUrl":"10.1186/s12891-025-08828-0","url":null,"abstract":"<p><strong>Background: </strong>Several clinical and biomechanical studies on tension band wiring (TBW) using a ring-pin system have been conducted, but no consensus has been reached on the ideal surgical technique. In this study, we aimed to determine the ideal interval and length of ring pins for the treatment of transverse olecranon fractures using TBW with a ring-pin system.</p><p><strong>Methods: </strong>A biomechanical study was performed using 32 fourth-generation composite ulnae and a ring-pin system specially designed for TBW. Four groups of eight sawbones were created based on the interval and length of the ring pins. A cyclic loading test was performed to measure stability during the active range of motion exercises. A load-to-failure test measured the maximal load until fixation loss.</p><p><strong>Results: </strong>All groups were stable, with a micromotion of < 1.0 mm, except for Group 3 (length: 50 mm, interval: 10 mm) during the cyclic loading test. The mean micromotion and displacement of Group 3 were significantly higher than those of Groups 2 and 4 (length: 90 mm, interval: 10 mm). The maximal load to failure in Group 3 was significantly lower than that of Groups 2 and 4.</p><p><strong>Conclusion: </strong>Inserting two ring pins in parallel at a 10-mm interval with a length of ≥ 70 mm for TBW in transverse olecranon fractures is recommended. Further widening of the pin interval provides no biomechanical benefit and may result in technical difficulties owing to the anatomical features of the ulna; in summary, 50-mm ring pins show significantly lower mechanical strength.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"568"},"PeriodicalIF":2.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and analgesic effect of local infiltration analgesia and femoral nerve block after anterior cruciate ligament reconstruction: a systematic review and meta-analysis.","authors":"Wenjuan Ma, Dongmei Zhao, Pengcheng Li, Li Liu, Mingpeng Yang, Jian Zhang, Jian Li","doi":"10.1186/s12891-025-08665-1","DOIUrl":"10.1186/s12891-025-08665-1","url":null,"abstract":"<p><strong>Background: </strong>Anterior cruciate ligament reconstruction (ACLR) is frequently associated with moderate to severe postoperative pain, necessitating effective analgesic strategies to enhance patient comfort and facilitate recovery. Identifying effective pain management methods after ACLR is crucial. This study aims to explore the best analgesia method with the local infiltration analgesia (LIA) and femoral nerve block (FNB) after ACLR.</p><p><strong>Methods: </strong>Cochrane Library databases, PubMed, MEDLINE and Embase were searched from inception to April 2024 with the following terms: \"anterior cruciate ligament\" AND \"reconstruction\" AND \"femoral nerve block\" AND \"local infiltration analgesia\" AND \"pain score\" AND \"morphine consumption\" AND \"analgesia duration\" AND \"complication\".</p><p><strong>Results: </strong>A total of 8 Level 1 randomized controlled trials (RCTs) were included in Meta analysis. The pain score of the FNB group was significantly lower than that of the LIA group at 8 to 12 h after the operation (MD = 1.78; 95% CI, [0.53, 3.03]; P = 0.005). There was no significant difference in pain scores between the two groups at 0 to 4, 4 to 8, and 12 to 24 h postoperatively. Within 24 h after surgery, there was no significant difference in intravenous morphine equivalent consumption between the two groups (MD = 3.76; 95% CI, [-0.82, 8.33]; P = 0.11). In terms of analgesic duration, there was also no significant difference between the two groups (MD = -3.03; 95% CI, [-7.34, 1.28]; P = 0.17). However, the incidence of nausea in the LIA group was higher than that in the FNB group (OR = 2.06; 95% CI, [1.03, 4.14]; P = 0.04).</p><p><strong>Conclusion: </strong>The FNB is superior to LIA for intraoperative control of postoperative pain in the first 8 to 12 h after ACLR. But there was no significant difference in pain control at other time points, morphine consumption, and analgesic duration between the two groups within 24 h after surgery. The LIA group had a higher incidence of nausea within 24 h after surgery.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"565"},"PeriodicalIF":2.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic assessment of sarcopenia in patients with fractures: a systematic review and meta-analysis.","authors":"Hejie Zheng, Tianhong Wang, Zhuoyang Li, Huimin Lu","doi":"10.1186/s12891-025-08775-w","DOIUrl":"10.1186/s12891-025-08775-w","url":null,"abstract":"<p><strong>Background: </strong>Currently, the prevalence of sarcopenia is on the rise. Sarcopenia may significantly affect the prognosis of fracture patients by increasing postoperative complications, diminishing quality of life, and raising mortality rates. This studyaims to investigate the impact of sarcopenia on the prognosis of fractures.</p><p><strong>Methods: </strong>A systematic search was carried out in PubMed, Embase, Cochrane Library, and Web of Science using the keywords \"sarcopenia\" and \"fracture\" from the inception of each database to January 14, 2025. The logarithm and its standard error of the odds ratio (OR) were calculated to assess the effect size. Sensitivity analysis was conducted using a one-by-one exclusion approach. Publication bias was evaluated through funnel plots, Egger's test, Begg's test, and the trim and fill method.</p><p><strong>Results: </strong>Our pooled analysis of data from 30 studies, comprising 32 datasets, demonstrated that sarcopenia significantly elevated the risk of poor prognosis in fracture patients (OR 1.51, 95% CI 1.24-1.85), particularly, the risk of refracture (OR 1.66, 95% CI 1.36-2.03). In hip fractures, sarcopenia similarly increased the risk of poor prognosis (OR 1.43, 95% CI 1.17-1.76), refracture (OR 1.54, 95% CI 1.21-1.96) and poor functional recovery (OR 2.13, 95% CI 1.41-3.21).</p><p><strong>Conclusion: </strong>Sarcopenia plays a crucial role as a risk factor for poor prognosis in patients with fractures, including both an elevated risk of mortality, refracture and poor functional recovery. This necessitates that clinical workers place greater emphasis on the identification and diagnosis of sarcopenia in practice, deliver enhanced clinical care tailored to fracture patients, conduct more prospective studies, and advocate for the global standardization of sarcopenia diagnostic criteria in the future.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"566"},"PeriodicalIF":2.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring heat shock protein-related biomarkers and subgroups in osteoarthritis using Gene Expression Omnibus data sets.","authors":"Weixin Cai, Boxin Yan, Hanbing Song, Jiaxing Liu, Geqiang Wang, Yichang Jiang","doi":"10.1186/s12891-025-08827-1","DOIUrl":"10.1186/s12891-025-08827-1","url":null,"abstract":"<p><p>Osteoarthritis (OA) is a degenerative joint disease marked by cartilage deterioration. Recent studies suggest that heat shock proteins (HSPs) may play a role in the pathophysiology of OA. This study explores the role of heat shock protein-related genes (HSRs) in OA using GEO datasets (GSE12021, GSE55457, GSE55235). Differential expression analysis identified 34 HSRs with significant changes in OA. Protein-protein interaction (PPI) network analysis highlighted central HSRs, including HSPA5, HSPA6, HSPA1L, HSPA12 A, and HSPH1, indicating their key roles in OA. Enrichment analysis revealed that HSRs are involved in protein folding, chaperone activities, and endoplasmic reticulum stress. A nomogram developed from HSR expression profiles demonstrated high accuracy in predicting OA risk. Clustering analysis identified two distinct HSR-related subgroups with unique gene expression and immune profiles. Variations in immune cell infiltration and immune pathway activities were observed between these subgroups. Overall, the study underscores the significance of HSRs in OA pathogenesis and suggests potential personalized therapeutic strategies based on distinct HSR-related subgroups.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"562"},"PeriodicalIF":2.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in the rotational alignment of the tibial component in total knee arthroplasty for varus osteoarthritis.","authors":"Guomin Li, Li Sun, Senlei Li, Kezhou Chen, Yankun Li, Rui Luo, Bo Li","doi":"10.1186/s12891-025-08808-4","DOIUrl":"10.1186/s12891-025-08808-4","url":null,"abstract":"<p><strong>Purposes: </strong>Currently, there is no gold standard for determining the rotational alignment of the tibial component in varus knee deformities. This study aims to identify an appropriate method for determining the rotational alignment of the tibial component in total knee arthroplasty (TKA) for varus osteoarthritis.</p><p><strong>Methods: </strong>This study explores the relationship between varus angles and various anatomical landmarks to identify the optimal landmark. A total of 174 patients with varus knee osteoarthritis (OA) were recruited between June 2019 and June 2022.</p><p><strong>Results: </strong>Statistical analysis and scatter plots revealed a significant negative correlation between the varus angle and the ATCC in all patients with knee OA. A significant positive correlation was observed between the varus angle and the patellar tendon (including PCL-PT and PCL-MSL) when the varus angle was ≤ 10°. However, the correlation between these parameters changed when the varus angle exceeded 10°.</p><p><strong>Conclusions: </strong>The study provides new insights into the rotational alignment of the tibial component in TKA for varus osteoarthritis, emphasizing the need for individualized alignment strategies based on anatomical landmarks and varus angle severity.</p><p><strong>Level of evidence: </strong>Level III, correlation study.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"559"},"PeriodicalIF":2.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between work-related musculoskeletal symptoms and burnout symptoms among preclinical and clinical dental students: a cross-sectional study.","authors":"Berkant Sezer, Duygu Sıddıkoğlu","doi":"10.1186/s12891-025-08796-5","DOIUrl":"10.1186/s12891-025-08796-5","url":null,"abstract":"","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"561"},"PeriodicalIF":2.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical evaluation of the H-Loop technique and single-row knotted technique for repairing upper third subscapularis tendon injuries.","authors":"Yi-Tao Yang, Yun Su, Zhuo Wang, Jin-Ming Zhang, Yi Long, Chen-Yang Meng, Xing-Hao Deng, Jing-Yi Hou, Rui Yang","doi":"10.1186/s12891-025-08743-4","DOIUrl":"10.1186/s12891-025-08743-4","url":null,"abstract":"<p><p>We evaluated the biomechanical performance of the new knotless H-Loop technique in repairing the upper third subscapularis (SSC) tendon tear, and compared these results with the single-row knotted technique. A total of 69 subscapularis tendons from sheep were collected, with 10 specimens randomly selected for comprehensive biomechanical testing after either complete tendon or upper third tear. An additional five specimens were dedicated to measuring the size and extent of the footprint area of the SSC tendon. The remaining 44 specimens were randomly and evenly divided into two groups: H-Loop(n = 11) and single-row knotted groups(n = 11). Contact area and pressure, ultimate tensile strength, stiffness, and elongation were assessed. Compared to the single-row knotted technique, the footprint contact pressure repaired by H-Loop technique was significantly larger (mean difference = 5.09 N, p = 0.004), but the footprint contact area (64.09 ± 10.37mm²) was similar to that of single-row knotted technique (58.27 ± 9.84mm²). The ultimate tensile strength and stiffness of the H-Loop technique were significantly greater than those of the single-row knotted technique (mean difference = 16.58 N, p = 0.003; mean difference = 0.82 N/mm, p = 0.002), while the peak-to-peak elongation was significantly lower (mean difference = 0.51 mm, p = 0.030). The primary failure mode for single-row knotted techniques is suture cut-through at the suture-tendon interface, while for the H-Loop technique, the main failure mode is related to the eyelet. The H-Loop technique provides higher tendon-bone contact pressure and mechanical strength with a smaller gap between the tendon and bone compared to the single-row knotted technique.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"558"},"PeriodicalIF":2.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and antibiotic sensitivity & resistance analysis of cases of orthopedic infections caused by Aeromonas hydrophila.","authors":"Yuyang Liu, Peisheng Chen, Fengfei Lin","doi":"10.1186/s12891-025-08806-6","DOIUrl":"10.1186/s12891-025-08806-6","url":null,"abstract":"<p><strong>Objective: </strong>This study was to elucidate the clinical characteristics and antibiotic susceptibility of orthopedic infections caused by Aeromonas hydrophila, thereby providing a suggestion for early clinical recognition and optimized managementof such infections in orthopedic clinical practice.</p><p><strong>Methods: </strong>A retrospective investigation was conducted by collecting general patient information, specimen sources, culture results, and antibiotic susceptibility data from 58 cases of Aeromonas hydrophila infections treated at our hospital between November 2020 and April 2024.</p><p><strong>Results: </strong>The 58 patients with Aeromonas hydrophila infections had a mean age of (50.05 ± 14.97) years, and the majority were workers. 56 cases were associated with traumatic open wounds, with injuries primarily caused by mechanical crushing or lacerations. The patients had an average hospital stay of approximately 33.97 days and underwent an average of 2.66 surgical procedures. In 5.17% of the cases, due to severe limb damage rendering replantation impossible, emergency amputations were performed shortly after admission. 23 cases eventually met the clinical cure criteria, and after improvement, were discharged; however, 5 cases experienced recurrences. 18 cases were monomicrobial A. hydrophila infections, while the remaining 40 cases showed polymicrobial involvement with at least one additional pathogen. Antibiotic susceptibility tests indicated low resistance rates of A. hydrophila to amikacin, aztreonam, cefpirome, and cefoperazone, whereas resistance rates to cefazolin and ampicillin were higher, with all specimens being resistant to ampicillin.</p><p><strong>Conclusion: </strong>Orthopedic infections caused by Aeromonas hydrophila predominantly affect middle-aged male industrial and agricultural workers, with the infection risk strongly associated with environmental exposure complexity during injury, particularly during mechanical operations and farming activities. Once infected, the disease progresses rapidly and severely, necessitating multiple surgical interventions. For antibiotic therapy, aminoglycosides and third- or fourth-generation cephalosporins are recommended treatment options, whereas first-generation cephalosporins should be avoided as first-line anti-infective agents.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"560"},"PeriodicalIF":2.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of risk factors for lower deep vein thrombosis (DVT) in patients over 60 years of age after total hip arthroplasty.","authors":"Maimaitiyibubaji Abudukadier, Tianyi Yuan, Hongjiang Liu, Zhiheng Zhou, Maimaitituersun Tuerdi, Abuduwupuer Haibier, Qing Lv, Yong Cui","doi":"10.1186/s12891-025-08820-8","DOIUrl":"10.1186/s12891-025-08820-8","url":null,"abstract":"<p><strong>Objective: </strong>To comprehensively analyze and evaluate risk factors for lower extremity deep vein thrombosis (DVT) in patients aged ≥ 60 years following total hip arthroplasty (THA), and to provide evidence-based recommendations for DVT prevention.</p><p><strong>Methods: </strong>A total of 462 patients who underwent THA at the our hospital from January 2019 to December 2023 were included in the study. Based on the occurrence of lower extremity deep vein thrombosis during follow-up, patients were divided into a DVT group (n = 65) and a non-DVT group (n = 397). The following variables were retrospectively analyzed for both groups: gender, age, body mass index, smoking status, alcohol consumption, medical history, operative time, anesthesia method, and preoperative and postoperative laboratory indicators (including triglycerides, TC, fibrinogen, hemoglobin, red cell distribution width, albumin, platelet count, D-dimer, INR, and FDP). Univariate analysis was conducted for these factors, with statistically significant variables subsequently included in a binary logistic regression model to examine their association with post-THA lower extremity deep vein thrombosis. ROC curve analysis was employed to evaluate the sensitivity and specificity of individual risk factors for DVT diagnosis, followed by development of a multivariate combined ROC curve model to assess its diagnostic value for DVT.</p><p><strong>Results: </strong>Binary logistic regression analysis revealed that preoperative hematocrit (P = 0.015, OR = 1.082), preoperative triglyceride levels (P = 0.030, OR = 1.275), preoperative platelet count (P = 0.008, OR = 1.005), preoperative D-dimer level (P < 0.001, OR = 3.407), diabetes mellitus (P = 0.004, OR = 2.735), smoking history (P = 0.003, OR = 2.733), and hypertension (P = 0.002, OR = 2.795) showed significant positive associations with lower extremity deep vein thrombosis following THA. These factors were identified as independent risk factors for post-THA DVT development.</p><p><strong>Conclusion: </strong>Preoperative hematocrit, triglycerides (TG), platelet count, D-dimer levels, smoking status, along with pre-existing hypertension and diabetes mellitus were all identified as significant risk factors for developing deep vein thrombosis following total hip arthroplasty. Surgeons should conduct comprehensive preoperative assessments of these risk factors and implement individualized prevention and treatment protocols to minimize the occurrence of lower extremity deep vein thrombosis.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"557"},"PeriodicalIF":2.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}