BMC Musculoskeletal Disorders最新文献

{"title":"Integrating bioinformatics and machine learning to identify biomarkers of branched chain amino acid related genes in osteoarthritis.","authors":"Xiao-Zhi ZhaYang, Yan-Xiong Chen, Wen-Da Hua, Zheng-Lin Bai, Yun-Peng Jin, Xing-Wen Zhao, Quan-Fu Liu, Zeng-Dong Meng","doi":"10.1186/s12891-025-08779-6","DOIUrl":"https://doi.org/10.1186/s12891-025-08779-6","url":null,"abstract":"<p><strong>Background: </strong>Branched-chain amino acids (BCAA) metabolism is significantly associated with osteoarthritis (OA), but the specific mechanism of BCAA related genes (BCAA-RGs) in OA is still unclear. Therefore, this research intended to identify potential biomarkers and mechanisms of action of BCAA-RGs in OA tissues.</p><p><strong>Methods: </strong>Differential genes were obtained from the Gene Expression Omnibus (GEO) database and intersections were taken with BCAA-RGs to identify candidate genes. The underlying mechanisms were revealed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Subsequently, by combining three machine learning algorithms to identify genes with highly correlated OA features. In addition, created diagnostic maps and subject Receiver operating characteristic curves (ROCs) to assess the ability of the signature genes to diagnose OA and to predict their possible roles in molecular regulatory network axes and molecular signaling pathways.</p><p><strong>Results: </strong>Eight candidate genes were acquired by intersecting 4,178 DEGs and 14 BCAA-RGs. Subsequently, five candidate biomarkers were obtained, namely SLC3A2, SLC7A5, SLC43A2, SLC43A1, and SLC7A7. Importantly, SLC3A2 and SLC7A5 were validated by validation set and qRT-PCR. Furthermore, the nomogram constructed by SLC3A2 and SLC7A5 exhibited excellent accuracy in predicting the incidence of OA. The enrichment results demonstrated that SLC3A2 and SLC7A5 were significantly enriched in ribosome, insulin signaling pathway, olfactory transduction, etc. Meanwhile, we also found XIST regulated SLC7A5 through hsa-miR-30e-5p, and regulated SLC3A2 through hsa-miR-7-5p.OIP5-AS1 regulated SLC7A5 and SLC3A2 through hsa-miR-7-5p. By the way, 150 drugs were identified, including Acetaminophen and Acrylamide, which exhibited simultaneous targeting of these two biomarkers.</p><p><strong>Conclusion: </strong>Based on bioinformatics, SLC3A2 and SLC7A5 were identified as biomarkers related to BCAA in OA, which may provide a new reference for the treatment and diagnosis of OA patients.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"517"},"PeriodicalIF":2.2,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiotherapy approaches for coccydynia: evaluating effectiveness and clinical outcomes.","authors":"Maria Blanco-Diaz, Laura Ruiz Palacios, Maria Del Rosario Martinez-Cerón, Borja Perez-Dominguez, Esther Diaz-Mohedo","doi":"10.1186/s12891-025-08744-3","DOIUrl":"https://doi.org/10.1186/s12891-025-08744-3","url":null,"abstract":"<p><strong>Background: </strong>Coccydynia, or tailbone pain, significantly impairs patients' quality of life, affecting daily activities such as sitting and transitioning between positions. It can arise from trauma, childbirth, repetitive strain, or idiopathic causes. Although conservative treatments like physiotherapy are widely employed, their clinical effectiveness remains uncertain due to inconsistent methodologies and varied outcomes reported in the literature.</p><p><strong>Objective: </strong>To evaluate the effectiveness of physiotherapy interventions, in reducing pain and improving functional outcomes in patients with coccydynia.</p><p><strong>Methods: </strong>A comprehensive search was conducted in PubMed, PEDro, Scopus, and Web of Science databases, including randomized controlled trials (RCTs) published between 1963 and 2024. The methodological quality was assessed using the PEDro scale and the Cochrane risk-of-bias tool. Inclusion criteria focused on studies evaluating conservative physiotherapy interventions in patients with coccydynia.</p><p><strong>Results: </strong>Nine RCTs comprising 532 participants were included. The Cochrane risk-of-bias assessment indicated a moderate to high risk in several domains, particularly in allocation concealment and blinding. ESWT demonstrated significant reductions in pain and improvements in functional outcomes, with benefits sustained up to six months in some cases. Manual therapy was particularly effective in recent-onset coccydynia, although its efficacy diminished over time. kinesiotaping (KT) improved pain perception but showed limited impact on disability measures. Six studies were rated as moderate to high quality (PEDro scores 6-7), while three were low quality (scores ≤ 4). Despite promising results, heterogeneity in interventions, small sample sizes, and short follow-up periods limited definitive conclusions.</p><p><strong>Conclusion: </strong>Physiotherapy interventions, particularly ESWT, are promising conservative treatment options for coccydynia. However, methodological variability and limited long-term follow-up hinder definitive conclusions. Future research should prioritize standardized protocols, larger sample sizes, and extended follow-up to strengthen the evidence base for clinical recommendations.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"514"},"PeriodicalIF":2.2,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-short stem intercalary prosthetic reconstruction for joint preservation in metaphyseal tumor management: a retrospective review of twenty-five cases.","authors":"Leming Mou, Dayong Liu, Wanping Zhu, Dengxing Lun, Shilong Zhu, Jingyu Zhang, Yancheng Liu, Yongcheng Hu","doi":"10.1186/s12891-025-08780-z","DOIUrl":"https://doi.org/10.1186/s12891-025-08780-z","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluates the outcomes, survival, and ASL incidence of ultra-short stem intercalary prosthetic reconstruction for tumors involving the metaphysis of bone.</p><p><strong>Methods: </strong>A retrospective analysis of 25 patients treated at two centers with wide resection for primary or metastatic bone tumors (femur, tibia, humerus) followed by reconstruction using ultra-short stem intercalary prostheses combined extracortical plates. Clinical outcomes were assessed using the Visual Analogue Scale (VAS) and Musculoskeletal Tumor Society (MSTS) score. Survival rates were calculated using the Kaplan-Meier method, and complications were classified according to the Henderson system.</p><p><strong>Results: </strong>The mean follow-up was 20.2 months (range, 3-101 months). The average length of the ultra-short stems was 41.3 ± 9.6 mm. Mean operative time was 164 ± 61.3 min, blood loss averaged 646.4 ± 375.5 ml and the mean defect size was 122 ± 52.1 mm. Postoperative VAS scores were significantly lower than preoperative levels (P < 0.05). The mean MSTS score was 24.2 ± 3.5 (range, 15-29). Kaplan-Meier analysis revealed prosthesis survival rates at 1, 2, 3, and 5 years of 91.7%, compared to patient survival rates of 74.5%, 52.7%, 52.7%, and 52.7%. Postoperative complications occurred in 12% of patients (3/25), including one case of aseptic loosening (ASL), and two patients required reoperation.</p><p><strong>Conclusions: </strong>Ultra-short stem intercalary prostheses with extracortical plates provide a viable, effective option for reconstruction of short bone stumps after tumor resection, offering improved functional outcomes and acceptable prosthesis failure rates.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"513"},"PeriodicalIF":2.2,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of nuchal ligament ossification resection on cervical stability after modified laminoplasty: a long-term follow-up study.","authors":"Chong Chen, Wenlin Ye, Tao Yu, Xing Cheng, Lutong Wang, Xingchen Zhao, Xiang Long, Jun Ouyang, Yunbing Chang, Xiaoqing Zheng","doi":"10.1186/s12891-025-08729-2","DOIUrl":"https://doi.org/10.1186/s12891-025-08729-2","url":null,"abstract":"<p><strong>Study design: </strong>A retrospective study.</p><p><strong>Objectives: </strong>This study aims to investigate the relationship between the resection of ossification of the nuchal ligament (ONL), its morphological features, and cervical stability following modified laminoplasty.</p><p><strong>Methods: </strong>We retrospectively reviewed the data of patients diagnosed as degenerative cervical myelopathy (DCM) who underwent modified laminoplasty with muscle-ligament complex (MLC) reconstruction in our hospital between July 2018 and October 2022. Demographic information (e.g., age, gender), cervical sagittal parameters, cervical angular displacement (AD), cervical horizontal displacement (HD), range of motion and patient-reported outcomes were compared between patients with and without ONL.</p><p><strong>Results: </strong>The cervical AD at C4-C5, C5-C6 and cervical HD at C5-6 were significantly higher in ONL (+) group than ONL (-) group before surgery and at the 24-month follow-up time (p < 0.05, all). The AD and HD at C4-C5 and C5-C6 were higher in ONL (+) segments before surgery and at the 24-month follow-up (p < 0.05, all). But the values of AD or HD were lower in ONL (+) segments at 3- or 6-month follow-up (p < 0.05, all). ONL (+) group with two or more consecutive segments demonstrate significantly increased cervical AD and HD at the C4-C5 level after a 24-month follow-up period (p < 0.01, both).</p><p><strong>Conclusion: </strong>Resection of the ONL, particularly involving ≥ 2 cervical segments, is moderately associated with an increased likelihood of cervical instability and abnormal sagittal alignment in long-term follow-up after laminoplasty. Reconstruction of the MLC during laminoplasty may enhance cervical stability in the early follow-up period. For DCM patients with long segmental ONL, more attention should be paid to protecting the MLC structure during posterior cervical surgery.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"511"},"PeriodicalIF":2.2,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden and projections of malignant neoplasm of bone and articular cartilage in China: an analysis for the global burden of disease study 2021.","authors":"Weiqiang Zeng, Wenlong Yang, Ge Yu, Pan Shen, Zhijun Zheng, Fengyun Yang","doi":"10.1186/s12891-025-08760-3","DOIUrl":"https://doi.org/10.1186/s12891-025-08760-3","url":null,"abstract":"<p><strong>Background: </strong>Malignant neoplasm of bone and articular cartilage (MNBAC) represents one of the most prevalent malignant tumours among adolescents. Assessing its disease burden trends is critical for formulating prevention strategies. This study aims to evaluate the temporal trends of MNBAC burden in China, project future trajectories over the next 15 years, and compare these patterns with global benchmarks.</p><p><strong>Methods: </strong>Data on incidence, prevalence, deaths, and disability-adjusted life years (DALYs) were extracted from the Global Burden of Disease (GBD) database 2021. Joinpoint regression analysed temporal trends, while decomposition analysis was used to investigate the impact of aging, population growth, and epidemiological factors on the deaths and DALYs rates of MNBAC. Additionally, we conducted BPAC model to project future trends to 2036. Spearman correlation assessed associations between the burden of MNBAC and the socio-demographic Index (SDI).</p><p><strong>Results: </strong>In 2021, China's age-standardised incidence rate (ASIR), age-standardised prevalence rate (ASPR), age-standardised mortality rate (ASMR) and age-standardised DALYs rate (ASDR) for MNBAC were 1.42, 9.16, 0.93, and 29.52 per 100,000 population, respectively. Compared to 1990, these metrics increased by 118.46%, 125.62%, 60.34%, and 46.43%. Age-specific analyses revealed a bimodal burden pattern globally, peaking in adolescent and elderly populations. Joinpoint regression identified fluctuating trends in China (initial declining, subsequent rise, and then in decline), contrasting with global pattern. Decomposition analysis indicated that the increasing MNBAC burden in China was primarily driven by population aging and epidemiological changes, whereas globally, population growth played a more significant role. Projections indicated modest declines in MNBAC burden for China and globally by 2036. Spearman correlation analysis showed that the ASIR and ASPR of MNBAC in China and globally were significantly positively correlated with SDI (P < 0.05), and the ASMR and ASDR of MNBAC were also positively correlated with SDI, but not significantly.</p><p><strong>Conclusions: </strong>This analysis underscores the substantial burden of MNBAC in China, surpassing global trends. While projections suggest gradual declines, the persistent high disability burden in youth and elderly populations necessitates strengthened screening protocols and prevention strategies. These findings provide critical epidemiological evidence for optimizing MNBAC management policies.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"512"},"PeriodicalIF":2.2,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for venous thrombosis after hip arthroplasty: a meta-analysis.","authors":"Wang Huang, Weiwei Hu, Bangguo Lei, Weichen Huang","doi":"10.1186/s12891-025-08764-z","DOIUrl":"10.1186/s12891-025-08764-z","url":null,"abstract":"<p><strong>Background: </strong>Venous thrombosis is a common complication after hip arthroplasty.</p><p><strong>Methods: </strong>PubMed, Embase, the Cochrane Library, and Web of Science were searched for case-control studies on risk factors for venous thrombosis after hip arthroplasty up to September 14, 2023. Data analysis was performed using Stata15.0.</p><p><strong>Results: </strong>This meta-analysis included 15 case-control studies, comprising 17,909 participants, including 1149 patients with venous thrombosis and 16,760 patients without venous thrombosis. The univariate meta-analysis results revealed that age over 70 years old, hypertension, BMI ≥ 25, operation time, stroke, and use of mechanical prophylaxis alone were risk factors for venous thrombosis after hip arthroplasty. Multivariate analysis showed that female, age > 70 years, BMI ≥ 25, cemented prosthesis, and a history of venous thrombosis were the risk factors for venous thrombosis after hip arthroplasty.</p><p><strong>Conclusions: </strong>This study suggests that female sex, age over 70 years, hypertension, a BMI of 25 or higher, duration of operation, stroke, mechanical prevention only, use of a cemented prosthesis, and a history of venous thrombosis are risk factors for venous thrombosis following hip arthroplasty.</p><p><strong>Clinical trial number: </strong>not applicable.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"508"},"PeriodicalIF":2.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and accuracy evaluation of novel 2D instant navigation system on spinal surgery - a preclinical study.","authors":"Wen Xia, Zhengyang Wu, Rui Zuo, Jiang Wu, Jing Ling, Linfeng Mo, Zegang Shi, Yue Zhou, Changqing Li, Wenjie Zheng, Chao Zhang","doi":"10.1186/s12891-025-08769-8","DOIUrl":"10.1186/s12891-025-08769-8","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Intraoperative navigation has significantly facilitated spinal surgery and enhanced surgical accuracy. Nevertheless, it is often encumbered by the need for expensive equipment, a complex workflow, and frequently exhibits inefficiencies. Leveraging permanent calibration technology, we have developed a novel two-dimensional fluoroscopic image navigation system with the aim of streamlining and expediting the navigation process. In this study, we comprehensively evaluated its feasibility and accuracy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The accuracy of the 2D-navigation system was rigorously assessed using a standardized high-precision mold. To validate the feasibility and accuracy of the novel navigation system for spinal surgery, the bare-bones of the pig lumbar spine are employed for evaluation. Subsequently, 2D navigation-assisted pedicle penetrations were meticulously carried out on the spine (L1-L5) of live animals. The navigation accuracy was quantified by comparing the visualized position of the surgical tool in the actual fluoroscopic image with the virtual position pre-planned by the navigation system.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;During the experimental process, an excellent correlation between the virtual fluoroscopic images and actual fluoroscopic images was prominently observed. The navigation positioning accuracy, as evaluated by the standardized high-precision mold, was determined to be 0.54±0.16mm (AP view) and 0.57±0.14mm (lateral view). Specifically, in the bare-bones of the pig lumbar spine, the average distance errors between the virtual and actual fluoroscopic images under anteroposterior and lateral views were 0.99±0.48mm and 0.87±0.60mm, respectively. Meanwhile, the average angle errors were 0.41±0.29 &lt;math&gt;&lt;mmultiscripts&gt;&lt;mrow&gt;&lt;/mrow&gt; &lt;mrow&gt;&lt;/mrow&gt; &lt;mo&gt;∘&lt;/mo&gt;&lt;/mmultiscripts&gt; &lt;/math&gt; and 0.37±0.11 &lt;math&gt;&lt;mmultiscripts&gt;&lt;mrow&gt;&lt;/mrow&gt; &lt;mrow&gt;&lt;/mrow&gt; &lt;mo&gt;∘&lt;/mo&gt;&lt;/mmultiscripts&gt; &lt;/math&gt; , respectively. In the surgical procedure on normal adult pigs (L1-L5), the average distance errors were 1.14±0.58mm(95% CI [0.50-0.59]) and 1.54±0.79mm(95% CI [0.11-0.12]), respectively. The corresponding average angle errors were 0.61±0.49 &lt;math&gt;&lt;mmultiscripts&gt;&lt;mrow&gt;&lt;/mrow&gt; &lt;mrow&gt;&lt;/mrow&gt; &lt;mo&gt;∘&lt;/mo&gt;&lt;/mmultiscripts&gt; &lt;/math&gt; (95% CI [0.33-0.35]) and 0.40±0.31 &lt;math&gt;&lt;mmultiscripts&gt;&lt;mrow&gt;&lt;/mrow&gt; &lt;mrow&gt;&lt;/mrow&gt; &lt;mo&gt;∘&lt;/mo&gt;&lt;/mmultiscripts&gt; &lt;/math&gt; (95% CI [0.33-0.47]), respectively. Throughout a single navigation registration and the entire surgical procedure, the navigation accuracy across the L1 to L5 segments remained consistently high, with no statistically significant differences detected among the segments (p&gt;0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The two-dimensional fluoroscopic image navigation system based on permanent calibration technology is characterized by a rapid and convenient workflow. It demonstrates high-level navigation accuracy, thereby meeting the stringent requirements for spinal navigation in live sur","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"510"},"PeriodicalIF":2.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of traumatic intervertebral disc injury on loss of correction following pedicle screw fixation for thoracolumbar fractures.","authors":"Tongfei Ge, Wenbo Li, Jiayang Wu, Qingyuan Wang, Cong Li, Siming Wang, Wu Xiong, Jin Fan","doi":"10.1186/s12891-025-08759-w","DOIUrl":"10.1186/s12891-025-08759-w","url":null,"abstract":"<p><strong>Background: </strong>Traumatic intervertebral disc injury, while frequently observed in thoracolumbar fractures, is often overlooked in clinical management. This research aimed to investigate how traumatic intervertebral disc injury influences spinal stability and to analyze the risk factors for correction loss after posterior pedicle screw fixation for thoracolumbar fractures.</p><p><strong>Methods: </strong>A retrospective analysis was performed on 194 thoracolumbar fracture patients who received pedicle screw fixation. The assessment of disc injury was conducted using magnetic resonance imaging (MRI). Patients were categorized into intervertebral disc injury (IDI) and non-IDI (nIDI) groups. The clinical variables included visual analog scale (VAS) score, and American Spinal Injury Association score. The radiological data, comprising the vertebral wedge angle (VWA), Cobb angle (CA), disc angle, disc height, anterior (AVBHr), midline (MVBHr), and posterior vertebral body height ratio (PVBHr), were compared before surgery, one week after the operation, and at final follow-up. The mean follow-up duration was 12.7 ± 7.0 months.</p><p><strong>Results: </strong>The mean VAS score showed significant improvement postoperatively. 22.6% of patients with IDI developed the intervertebral vacuum phenomenon. The IDI group exhibited significantly greater CA and VWA, as well as lower disc height, AVBHr and MVBHr than the non-IDI group at the last follow-up. Age (odds ratio [OR] = 1.038, 95% confidence interval [CI] = 1.011-1.066, P = 0.005), male (OR = 2.201, 95% CI = 1.107-4.377, P = 0.025), and IDI (OR = 2.463, 95% CI = 1.105-5.489, P = 0.028) were statistically significant risk factors for kyphosis correction loss according to multivariate logistic regression analysis.</p><p><strong>Conclusion: </strong>Traumatic IDI contributes to loss of correction following thoracolumbar fractures and is closely associated with accelerated disc degeneration. Age, male, and IDI are independent risk factors for postoperative kyphosis recurrence in patients with thoracolumbar fractures.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"507"},"PeriodicalIF":2.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptation of the Upper Limb Functional Index (ULFI) to a Polish version and validation in patients with upper limb musculoskeletal disorders.","authors":"Agnieszka Bejer, Jędrzej Płocki, Marek Kulczyk, Markus Melloh","doi":"10.1186/s12891-025-08758-x","DOIUrl":"10.1186/s12891-025-08758-x","url":null,"abstract":"<p><strong>Background: </strong>The Upper Limb Functional Index (ULFI) is a robust, widely used tool for assessing the functional status of the upper limbs (ULs) and the effectiveness of interventions in patients with musculoskeletal disorders (MSDs). This study aimed to translate and culturally adapt the ULFI into Polish (ULFI-PL) and evaluate its psychometric properties and practical characteristics.</p><p><strong>Methods: </strong>A total of 127 patients (54% female, <math><mover><mi>x</mi> <mo>¯</mo></mover> </math>  = 45.07 ± 14.97 years) with various ULMSDs and symptom durations completed the ULFI-PL, the shortened Disabilities of the Arm, Shoulder, and Hand questionnaire-Polish version (QuickDASH-PL), the Polish version of the World Health Organization Quality of Life-BREF (WHOQOL-BREF-PL), Numeric Pain Rating Scale (NPRS), and the seven-point Global Rating of Change (GRC) scale. The internal consistency, construct validity, and factor structure were assessed in all the participants; the test-retest reliability and measurement error were evaluated in a subgroup (n = 112, 2-3-day interval); and the responsiveness and interpretability were evaluated in another subgroup (n = 56, 8-week interval, after physiotherapy).</p><p><strong>Results: </strong>The ULFI-PL demonstrated a good internal consistency (α = 0.77) and high construct validity, supported by the confirmation of five out of six a priori hypotheses (83.33%). A confirmatory factor analysis (CFA) revealed a unidimensional structure. It also demonstrated a high test-retest reliability (r = 0.85). The measurement error was calculated using the standard error of measurement (SEM = 4.75%) and the minimal detectable change (MDC₉₅ = 13.17%). The ULFI-PL showed a high responsiveness after physiotherapy, which was confirmed by the effect size (ES = 2.08) and the standardized response mean (SRM = 1.88). The minimal clinically important difference (MCID) for the ULFI-PL was 28.29% (95% CI: 24.96-31.63).</p><p><strong>Conclusions: </strong>The ULFI-PL is a reliable, valid, and responsive tool for assessing the upper limb function in Polish-speaking patients with ULMSDs and is suitable for use in both clinical and research contexts. The results are consistent with previous studies on the original English version and other language adaptations.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"506"},"PeriodicalIF":2.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title of the study: finite element analysis of five internal fixation modalities for Schatzker type IV‒C tibial plateau fractures.","authors":"Zulong Zhou, Run Fang, Yulong Liu, Mingxiang Liu, Lingchao Kong, Rende Ning","doi":"10.1186/s12891-025-08770-1","DOIUrl":"10.1186/s12891-025-08770-1","url":null,"abstract":"<p><strong>Background: </strong>This study aims to evaluate the biomechanical performance of five different internal fixation strategies for Schatzker type IV-C tibial plateau fractures using three-dimensional finite element analysis. By analyzing stress distribution and displacement patterns under physiological load, we seek to identify optimal fixation modalities for clinical application.</p><p><strong>Methods: </strong>We established a three-dimensional finite element model of Schatzker IV-C tibial plateau fractures and evaluated five internal fixation modalities via finite element analysis. These modalities included a medial plate (Model 1), a medial plate with two posterior tension screws (Model 2), a medial plate with two lateral tension screws (Model 3), a posterior medial double plate (Model 4), and a medial lateral double plate (Model 5). To simulate the biomechanics of unilateral knee axial compression during normal adult gait, an axial force of 1,200 newtons (N) was applied, with 60% of the force distributed to the medial plate. We comprehensively analyzed equivalent von Mises stresses, displacements, and equivalent stress-displacement plots for each fixation.</p><p><strong>Results: </strong>Model 5 demonstrated the best overall performance in terms of internal fixation stress (91.46 MPa) and fracture block stress (10.826 MPa), suggesting optimal stress distribution and fracture block protection. Model 3 performed best in terms of internal fixation displacement (4.391 mm), suggesting an advantage in fracture block stability. While the models performed well in several areas, the double plate fixation scheme was superior in terms of stress distribution and fracture stability. It is ideal for managing complex fractures.</p><p><strong>Conclusions: </strong>A single medial plate (Model 1) provides adequate fixation and stability for fractures without the lateral intercondylar ridge. Lag screws with the medial plate (Models 2 and 3) effectively reduce stress and minimize trauma. Double plate on the posterior medial side (Model 4) significantly enhances fixation and prevents displacement for complex fractures. Medial-lateral double plate fixation (Model 5) provides the most favorable biomechanical stability for fractures with extensive lateral plateau comminution. However, balance the benefits against increased complexity, particularly in patients with compromised soft tissue or high functional demands. Selecting internal fixation based on the fracture line can optimize outcomes and speed recovery.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"509"},"PeriodicalIF":2.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}