BMC Musculoskeletal Disorders最新文献

{"title":"Importance of osteoporosis screening in the perimenopausal age.","authors":"Kholoud Alzain, Hana Alqahtani, Hatun Alnami, Nourah Bin Klaib, Enas Bedaiwi, Ghaida Alshehri, Faiha Ayoub, Zenat Khired","doi":"10.1186/s12891-025-09116-7","DOIUrl":"10.1186/s12891-025-09116-7","url":null,"abstract":"<p><strong>Objectives: </strong>The level of awareness of Saudi perimenopausal women regarding the importance of osteoporosis screening should be determined, and obstacles that prevent/delay them from doing so should be identified.</p><p><strong>Methods: </strong>This was a national-level cross-sectional study conducted during the months of September and October 2021. A total of 1716 respondents were women, after men and any woman younger than 40 years were excluded.</p><p><strong>Results: </strong>Participants' awareness was identified by five questions, dividing the cohort into three groups. Only 22 (1.3%) participants were completely aware, 12 (0.7%) participants had no idea about screening, and the remaining 1682 (98%) participants were partially aware. The aware group was significantly associated with only being older and already diagnosed with osteoporosis (p < 0.001). The obstacles that prevented participants from performing screening were significantly associated with a lack of doctor advice and requests (p < 0.001) and with participants being worried about other diseases (p < 0.001), age (p < 0.001), level of education (p = 0.013) and monthly income (p < 0.001).</p><p><strong>Conclusion: </strong>Although osteoporosis is a preventable disease, unfortunately, only 22 (1.3%) participants were fully aware of the importance of osteoporosis screening. Therefore, more efforts are needed from all doctors dealing with perimenopausal women to discuss and screen them.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"941"},"PeriodicalIF":2.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autograft bone grafting via surgical hip dislocation for collapsed necrotic femoral head: a mid-term retrospective study.","authors":"Min-Cong He, Bang-Ning Gu, Peng Peng, Qing-Wen Zhang, Qiu-Shi Wei, Wei He","doi":"10.1186/s12891-025-09176-9","DOIUrl":"10.1186/s12891-025-09176-9","url":null,"abstract":"","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"943"},"PeriodicalIF":2.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of denosumab in treatment of osteoporosis in patients with rheumatoid arthritis: a meta-analysis and systematic review.","authors":"Runyao Zhang, Nannan Kou, Feifei Liu, Hongliang Zhou, Lirong Ren","doi":"10.1186/s12891-025-09206-6","DOIUrl":"10.1186/s12891-025-09206-6","url":null,"abstract":"","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"942"},"PeriodicalIF":2.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduction quality and hip function after internal fixation of acetabular double column fractures combined with posterior wall fractures with Stoppa approach in comparison to ilioinguinal approach.","authors":"Weicheng Lin, Chao Zhang, Xi Yang, Ming Gao","doi":"10.1186/s12891-025-09148-z","DOIUrl":"10.1186/s12891-025-09148-z","url":null,"abstract":"","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"940"},"PeriodicalIF":2.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stability characteristics of medial meniscus tear in mild varus knee: a finite element analysis.","authors":"Chengyue Yu, Wenjun Zhao, Kexin Liu, Xiaoyuan Duan, Xiaokang Gao, Lupeng Wang, Jinwei Liu, Jiahe Xu, Jiashi Zeng, Guangdong Chen, Desheng Chen, Guosheng Xing, Weiguo Xu","doi":"10.1186/s12891-025-09046-4","DOIUrl":"10.1186/s12891-025-09046-4","url":null,"abstract":"<p><strong>Background: </strong>Recent studies have pointed out that varus alignment is a potential risk factor for medial overload and the development of osteoarthritis, which may influence the healing of meniscus tears. This study aimed to analyze the stress distribution of radial and longitudinal meniscal tears in mild varus knee and use it to explore the effects of varus alignment, tear type and length on the healing potential of medial meniscal tears.</p><p><strong>Methods: </strong>A healthy volunteer was recruited, and computed tomography (CT) and magnetic resonance imaging (MRI) scans of the right knee were performed to develop a subject-specific three-dimensional finite element model at a neutral position of 0° and with tibial varus angles of 3°, 6°, and 9°. The model contained bone structures (femur, tibia, fibula) and soft tissues (menisci, cartilage, ligaments). Stable and unstable radial tears and stable and unstable longitudinal tears (located in the white, red-white, or red zones) were introduced in the posterior medial meniscus, followed by finite element analysis.</p><p><strong>Results: </strong>The peak contact pressure in the medial compartment increased linearly with increasing varus angle (Slope = 1.3599, R² = 0.99223). When the varus increases by 1°, the corresponding peak contact pressure increased by an average of 0.46 MPa. In the case of varus knee, the maximum stress in radial tears was localized at the tear apex. Additionally, the stress of unstable radial tears was higher than that of stable radial tears. The stress distribution on the inner and outer surfaces of longitudinal tears depended on the varus alignment and the tear position. With increasing varus angle, stable longitudinal tears in the red-white and white zones showed a gradual decrease in favourable stress differences(White zone: 0.39 MPa→0.20 MPa; Red-white zone: 0.53 MPa→0.36 MPa), while unfavourable stress differences emerged (White zone: 0.20 MPa→-0.40 MPa, while unfavourable stress differences emerged (White zone: 0.20 MPa→-0.40 MPa; Red-white zone: 0.36 MPa→-0.43 MPa). Unstable longitudinal tears in the white zone exhibited increased unfavourable stress differences(-0.18 MPa→-0.52 MPa). Notably, unstable longitudinal tears consistently demonstrated unfavourable stress differences even under mild varus conditions.</p><p><strong>Conclusion: </strong>To our knowledge, this study is among the first to investigate the influence of varus alignment on stress distribution in meniscal tears using finite element analysis. This study investigates two types of radial tears and two types of longitudinal tear prototypes in three zones simultaneously. This study provides novel insights into how varus alignment influences stress distribution in meniscal tears, suggesting its potential role in guiding treatment decisions. Future studies incorporating clinical data are warranted to validate these findings.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"944"},"PeriodicalIF":2.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arthroscopic transition from suture anchors to transosseous suture technique for treating rotator cuff tear with osteoporosis- a case report.","authors":"Kairui Zhang, Zheng Yan, Zhefeng Jin, Guoqing Cui, Liguo Zhu, Jie Yu, Yinzhe Cui, Minshan Feng, Jiawen Zhan, Jia Ma","doi":"10.1186/s12891-025-09078-w","DOIUrl":"10.1186/s12891-025-09078-w","url":null,"abstract":"<p><strong>Background: </strong>Rotator cuff repair using suture anchors (SA) is the current standard; however, in osteoporotic patients, anchor pullout can compromise surgical outcomes. Transosseous rotator cuff repair (TO-RCR), especially the Open-Box (OBOX) technique, has emerged as a viable anchorless alternative offering superior biomechanical advantages.</p><p><strong>Case presentation: </strong>A 73-year-old woman with a full-thickness rotator cuff tear and osteoporosis underwent arthroscopic SA repair. During surgery, anchor pullout occurred due to poor bone quality. The surgical team immediately transitioned to the OBOX technique, involving vertically crossed bone tunnels and eight-point tendon fixation using six high-strength sutures. Postoperative recovery was uneventful, with substantial improvements in range of motion and functional scores (Constant-Murley score: 93、UCLA score: 33 at 8 months). MRI confirmed successful tendon healing, demonstrating features of Sugaya type II classification.</p><p><strong>Conclusion: </strong>This case demonstrates that the OBOX transosseous suture method may be a viable option when anchor failure occurs during rotator cuff repair, especially in osteoporotic patients. Further research is warranted to assess long-term outcomes and broader clinical applications.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"927"},"PeriodicalIF":2.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electromyography does not show adequate effectiveness in diagnosis of suprascapular nerve lesions caused by rotator cuff tear in rat model.","authors":"Yawen Guo, Zhongwei Qian, Haoliang Wang, Hongfang Xu, Su Liu, Yucheng Sun, Zhenjie Zhu","doi":"10.1186/s12891-025-09195-6","DOIUrl":"10.1186/s12891-025-09195-6","url":null,"abstract":"<p><strong>Background: </strong>Suprascapular nerve lesions caused by rotator cuff tears have been widely reported. However, the accuracy of electromyography as a definitive diagnostic method for nerve lesions is controversial. This study aims to evaluate the diagnostic effectiveness of electromyography for nerve lesions following varying degrees of rotator cuff tears in rat models.</p><p><strong>Methods: </strong>Twenty rats underwent bilateral rotator cuff tenotomy and were divided into four groups to simulate clinically relevant rotator cuff tears of different sizes. The supraspinatus tendon free ends in three groups were sutured at the tendon insertion site, the humeral head midpoint, and the coracoid process base. The fourth group underwent free retraction following supraspinatus and infraspinatus tendon transection. Nerve lesion incidence was assessed using in vivo electromyography under anesthesia and Neurofilament-Heavy immunofluorescence staining of the suprascapular nerve after sacrifice at 2 weeks postoperatively.</p><p><strong>Result: </strong>The area under the receiver operating characteristic curve (AUC) for both single and combined electromyography indicators of nerve entrapment was < 0.7, indicating low diagnostic effectiveness. Immunofluorescence staining revealed a statistically significant positive correlation between nerve lesion incidence and tear size.</p><p><strong>Discussion: </strong>Although widely used clinically, electromyography lacks sufficient diagnostic accuracy for suprascapular nerve lesions following rotator cuff tears. This underscores the need for surgeons to carefully evaluate suprascapular nerve integrity in such cases.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"931"},"PeriodicalIF":2.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A straightforward tendon transfer technique for extensor pollicis longus tendon rupture.","authors":"ChungTing Liu","doi":"10.1186/s12891-025-09220-8","DOIUrl":"10.1186/s12891-025-09220-8","url":null,"abstract":"","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"937"},"PeriodicalIF":2.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accumulation of lipids after acute direct and indirect traumatic injuries in male and female mice.","authors":"Angela S Bruzina, Braydon A Crum, Christiana J Raymond-Pope, Jarrod A Call, Sarah M Greising","doi":"10.1186/s12891-025-09207-5","DOIUrl":"10.1186/s12891-025-09207-5","url":null,"abstract":"<p><strong>Background: </strong>Adipose infiltration and lipid droplet accumulation are implicated in metabolic diseases and are known to limit skeletal muscle repair and regeneration. However, their role in skeletal muscle injury, particularly volumetric muscle loss (VML), remains unclear. We aimed to characterize early lipid and adipokine responses following direct (i.e., VML) and indirect (i.e., denervation) traumatic injuries.</p><p><strong>Methods: </strong>Adult male and female C57Bl/6J mice (n = 36) were randomized to VML injury to the posterior hindlimb, tibial nerve denervation, or remained injury Naïve. Three days post, in vivo muscle function was assessed. Serum and gastrocnemius muscle tissue were assessed for histological and biochemical analyses.</p><p><strong>Results: </strong>A decrease in total myofiber number occurred post-VML with a reduction in force and increased fatigue. Lipid droplet-associated proteins displayed injury- and myofiber type-specific changes, with VML exhibiting accumulation of perilipin 5 localized to the injury site. Lipid droplets in the muscle remaining were significantly greater post-VML compared to denervation. The pro-inflammatory adipokine IL-6 and growth factor IGF-1 were markedly increased in the muscle remaining post-VML, while circulating metabolic regulators, adiponectin and leptin, were suppressed.</p><p><strong>Conclusions: </strong>These findings underscore lipid droplet dynamics and adipokine signaling disruptions following indirect and direct traumatic injuries in a preclinical model. Future work should be done to explore aspects of lipid droplet regulation temporally following skeletal muscle injuries, as early accumulation may suggest an additional etiology in the pathological sequelae of injury.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"932"},"PeriodicalIF":2.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of glutaminase 1 inhibitor on rotator cuff derived cells: a preliminary report in 12 patients.","authors":"Tatsuo Kato, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Shintaro Mukohara, Tomoya Yoshikawa, Issei Shinohara, Takahiro Furukawa, Shuya Tanaka, Masaya Kusunose, Yuichi Hoshino, Takehiko Matsushita, Tomoyuki Matsumoto, Ryosuke Kuroda","doi":"10.1186/s12891-025-09105-w","DOIUrl":"10.1186/s12891-025-09105-w","url":null,"abstract":"<p><strong>Background: </strong>Glutaminase 1 (GLS1) degrades glutamate into glutamine and ammonia, and is required for the survival of senescent human cells. GLS1 inhibitors contribute to the improvement of various pathological conditions associated with aging. Rotator cuff tears (RCT) increase with age, and recently the Stump classification has been proposed to evaluate the fragility of the torn rotator cuff site, with Type 3 being the most fragile and a high risk of re-tear after rotator cuff repair surgery. We hypothesized that GLS1 expression is upregulated in the degenerated rotator cuff and that GLS1 inhibitors would improve rotator cuff degeneration. In this study, we evaluated the effects of GLS1 inhibitors on human rotator cuff-derived cells.</p><p><strong>Methods: </strong>Twelve patients who underwent surgery for RCT were included in this study. Rotator cuff tissue was harvested during arthroscopic repair for tissue and cell evaluation. Tissue evaluation involved quantitative assessment of mRNA expression of GLS1 using real-time PCR (qPCR) and immunostaining. Rotator cuff-derived cells were isolated and cultured, divided into four groups: (1) Control group (without IL-1β and GLS1 inhibitor), (2) IL-1β(-)/GLS1 inhibitor(+), (3) IL-1β(+)/GLS1 inhibitor(-), (4) IL-1β(+)/GLS1 inhibitor(+). Cell viability was evaluated by WST assay and mRNA expression was evaluated by qPCR at 48 h after treatment. The expression of p16 and Scleraxis (SCX) was also evaluated by fluorescent immunostaining.</p><p><strong>Results: </strong>Tissue evaluation showed significantly higher expression of GLS1 in Stump classification Type 3. Cell viability was significantly decreased by IL-1β loading and increased by the GLS1 inhibitor. The mRNA expression levels of GLS1, IL-6, p16 and p21 were decreased by the GLS1 inhibitor. The mRNA expression of the tendon markers, type 1 collagen, Mohawk and SCX were increased by the GLS1 inhibitor. Immunostaining revealed that the GLS1 inhibitor decreased p16 expression and increased SCX expression.</p><p><strong>Conclusions: </strong>This study showed that GLS1 was upregulated in the degenerated rotator cuff, and that the administration of a GLS1 inhibitor decreased inflammation and aging markers while increasing cell viability and tendon markers in rotator cuff-derived cells. These results indicate that GLS1 inhibitors exert anti-inflammatory effects in rotator cuff tears, prevent age-related degeneration of the rotator cuff, and promote tendon repair.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"935"},"PeriodicalIF":2.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}