BMC Musculoskeletal Disorders最新文献

{"title":"Effect of aerobic exercise on cardiopulmonary fitness among people with knee osteoarthritis: a systematic review and meta-analysis.","authors":"Shan Su, Clare Chung-Wah Yu, Emma Feng-Ming Zhou, Jing-Yuan Liu, Siu-Ngor Fu","doi":"10.1186/s12891-025-08746-1","DOIUrl":"10.1186/s12891-025-08746-1","url":null,"abstract":"<p><strong>Background: </strong>Although aerobic exercise is widely recommended to enhance cardiopulmonary fitness and mitigate cardiovascular risk, the efficacy and effectiveness of aerobic exercise interventions have not been comprehensively evaluated among people with knee osteoarthritis (OA). This systematic review and meta-analysis aimed to synthesize the current evidence on the impact of aerobic exercise on cardiopulmonary fitness in people with knee OA.</p><p><strong>Methods: </strong>PubMed, Embase, Scopus, and Web of Science were searched from inception to March 1, 2024, for randomized controlled trials (RCTs). Eligible RCTs included those with an aerobic exercise intervention (e.g., aerobic walking, cycling, aquatic aerobics), a primary outcome of maximum oxygen consumption (VO₂ max), and participants with knee OA. The aerobic exercise programs were compared to control interventions (e.g., education, light-intensity exercise, usual activities, and routine care). Secondary outcomes included distance (m) walked during the six-minute walk test (6MWD), and Patient-Reported Outcome Measures (i.e., pain score and disability score). The overall level of evidence was assessed by the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.</p><p><strong>Results: </strong>Out of 988 studies, 5 RCTs with 459 people with knee OA were included in the analysis. Aerobic exercise programs included walking, cycling, jumping, stepping, and aquatic aerobics. Pooled mean differences and 95% confidence intervals (CIs) were 0.90 ml/kg/min (95% CI 0.43 to 1.38; moderate evidence), 46.97 m (95% CI 33.71 to 60.23; high evidence), 5.59 points (95% CI 2.93 to 8.25; low evidence), and 3.03 points (95% CI 1.05 to 5.01; moderate evidence) for VO₂ max, 6MWD, pain and disability, respectively.</p><p><strong>Conclusion: </strong>These results support the hypothesis that aerobic exercise can elicit improvements in cardiopulmonary fitness for people with knee OA. Future research should focus on optimizing current exercise regimens for people with knee OA and exploring how to improve adherence while minimizing symptom exacerbation by other exercise modalities, e.g., Nordic walking and inspiratory muscle training.</p><p><strong>Systematic review registration: </strong>CRD42022340966, 07/07/2022, PROSPERO.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"549"},"PeriodicalIF":2.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finite element fracture load analysis and dark-field X-ray imaging of osteoporotic and healthy vertebrae in human lumbar spine specimens.","authors":"N Hesse, D Strack, J F Rischewski, F T Gassert, A Kufner, T Urban, M E Lochschmidt, B J Schwaiger, C Braun, D P Mueller, D Pfeiffer, T Baum, K Subburaj, F Pfeiffer, A S Gersing","doi":"10.1186/s12891-025-08709-6","DOIUrl":"10.1186/s12891-025-08709-6","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the association of measurements from a clinical X-ray dark-field prototype system and CT-based finite element analysis (FEA) in lumbar spine specimens.</p><p><strong>Materials and methods: </strong>In this prospective study, human cadaveric spine specimens (L2 to L4) were examined using a clinical prototype for dark-field radiography, yielding both attenuation and dark-field images. Specimens were scanned in vertical and horizontal positions. Volumetric bone mineral density (BMD) values were derived from quantitative CT measurements. Bone segmentation masks derived from CT-images were used for FEA-estimated fracture load (FL) calculations. FEA-estimated FL, dark-field, and attenuation signals were compared between osteoporotic/osteopenic (BMD < 120 mg/cm³) and non-osteoporotic/osteopenic specimens using the paired t-test and the Wilcoxon Mann-Whitney U test. Associations were tested using Spearman correlation.</p><p><strong>Results: </strong>Fifty-nine vertebrae from 20 lumbar spine specimens (mean age, 73 years ± 13; 11 women) were studied. FEA-estimated FL correlated with BMD (r = 0.75, p < .001) and was significantly lower in osteoporotic/osteopenic vertebrae (1222 ± 566 vs. 2880 ± 1182, p < .001). Dark-field and attenuation signals were positively correlated with FEA-estimated FL, in both vertical (r_darkfield = 0.64, p < .001, r_attenuation = 0.82, p  < .001) and horizontal position (r_darkfield = 0.55, p < .001, r_attenuation = 0.81, p < .001).</p><p><strong>Conclusion: </strong>Dark-field and attenuation signals assessed using a clinical X-ray dark-field system significantly correlated with FEA-estimated FL in human spine specimens with and without osteoporosis/osteopenia. Dark-Field imaging may complement existing assessment methods for bone strength as a dose-efficient, accessible tool.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"545"},"PeriodicalIF":2.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative analysis of the effects of proprioception and virtual reality exercises on postural balance in athletes with anterior cruciate ligament reconstruction: a systematic review and meta-analysis.","authors":"Ali Shamsi Majelan, Omid Shahani, Mohammad Amin Safaei Ghaleh Zo, Mahla Arman Far","doi":"10.1186/s12891-025-08823-5","DOIUrl":"10.1186/s12891-025-08823-5","url":null,"abstract":"","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"550"},"PeriodicalIF":2.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of LCL finding after post-op ACLR with anterior tibial translation, femorotibial rotation, knee scores, and functional performance: a retrospective cohort study.","authors":"Ahmet Serhat Genç, Mirsad Yalçınkaya, Egemen Ermiş, Enes Akdemir, Berna Anıl, Esra Korkmaz Salkılıç, Eren Şahin, Ali Kerim Yılmaz","doi":"10.1186/s12891-025-08799-2","DOIUrl":"10.1186/s12891-025-08799-2","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to examine the relationships between anterior tibial translation (ATT) distance, femorotibial rotation (FTR) angle, coronal lateral collateral ligament (LCL) sign, and functional lower extremity results obtained from single leg hop tests (SLHT), which are indirect magnetic resonance imaging (MRI) findings used to assess knee instability following anterior cruciate ligament (ACL) tear detection and ACL reconstruction (ACLR).</p><p><strong>Methods: </strong>This study included a total of 28 patients, 12 females (43%) and 16 males (57%), aged 18-40 years with ACL tear. Pre-operative (pre-op) ATT distance, FTR angle and LCL sign were measured by MRI, and Lysholm Knee Scoring Scale (LKSS), International Knee Documentation Committee Score (IKDC) and Tegner Activity Score (TAS) were measured and recorded by patient self-assessment. At six months post-operatively (post-op), the SLHT test was conducted alongside the same measurements. Differences between pre-op and post-op results, as well as correlations between post-op test outcomes, were analyzed based on the presence of the LCL sign.</p><p><strong>Results: </strong>After ACLR, there was no significant difference in ATT distance (p = 0.061) or FTR angle (p = 0.470) compared to the pre-op period. The presence of the post-op LCL sign did not lead to significant differences in ATT distance, FTR angle, LKSS, TAS, or any SLHT results (p > 0.05). However, the presence of LCL sign was associated with a significant increase in the IKDC scale (p = 0.047, ES=-0.78). In analyzing the correlations between ATT, FTR results, their changes, knee scores, SLHT results on the operative side, and limb symmetry index (LSI) ratios, significant correlations were found in various parameters for the entire group and the group without the LCL sign. In contrast, no significant correlations were found between any parameters in the group with the LCL sign (p > 0.05).</p><p><strong>Conclusions: </strong>ACLR did not result in a significant change in indirect MRI findings (ATT distance, FTR angle, and LCL sign) at the 6-month post-op mark. Additionally, the LCL sign was not a distinguishing factor in knee scores or lower extremity functional performance at six months post-op. In order to understand the potential effects of the LCL finding, longer follow-up and studies evaluating various sub-parameters such as age, gender, different surgical techniques are needed.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"553"},"PeriodicalIF":2.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study protocol: the SPInal NAVigation (SPINAV) trial - comparison of augmented reality surgical navigation, conventional image-guided navigation, and free-hand technique for pedicle screw placement in spinal deformity surgery.","authors":"Victor Gabriel El-Hajj, Anastasios Charalampidis, Daniel Fell, Erik Edström, Adrian Elmi-Terander, Paul Gerdhem","doi":"10.1186/s12891-025-08817-3","DOIUrl":"10.1186/s12891-025-08817-3","url":null,"abstract":"<p><strong>Background and purpose: </strong>Although navigation is increasingly used in spinal surgery, the advantage of different navigation technologies is still a matter of debate. Conventional image-guided navigation is currently the gold standard. However, modern, Augmented reality-based navigation methods are increasingly gaining ground. Surgical navigation in deformity surgery allows placement of pedicle screws in small and deformed pedicles and may result in both a higher accuracy and density of pedicle screw placement. The aim of this trial is to compare AR and conventional surgical navigation to free-hand technique.</p><p><strong>Patients and methods: </strong>This is a single center, open label, parallel assignment, three arm, randomized, controlled trial, comparing: Augmented reality surgical navigation (ARSN), Infrared surgical navigation (IRSN) and Free-hand (FH) technique. Individuals scheduled for spinal deformity surgery are eligible for inclusion. The inclusion criteria are written informed consent, age ≥ 12 years and spinal deformity. Subjects will be randomized intraoperatively and strictly sequentially.</p><p><strong>Outcomes: </strong>The primary endpoint is accurately placed pedicle screws based on intraoperative verification cone beam computed tomography (CBCT) scan. All radiological image analyses, on both intra- and postoperative imaging will be performed postoperatively by blinded reviewers. Several secondary outcome measures including revision rate, radiation exposure, implant density and final accuracy will be analyzed. Patient reported outcomes will also be assessed. Finally, a cost-benefit analysis will be performed.</p><p><strong>Start of trial and estimated duration: </strong>The SPINAV trial started recruiting patients in January 2022 and will continue for approximately 2.5 years.</p><p><strong>Trial registration: </strong>The trial is registered at clinicaltrials.gov (NCT05107310) on 2021-11-03.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"543"},"PeriodicalIF":2.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of an interpretable nomogram for predicting the risk of the prolonged postoperative length of stay for tuberculous spondylitis: a novel approach for risk stratification.","authors":"Parhat Yasin, Haopeng Luan, Cong Peng, Xinghua Song","doi":"10.1186/s12891-025-08807-5","DOIUrl":"10.1186/s12891-025-08807-5","url":null,"abstract":"<p><strong>Background: </strong>Tuberculous spondylitis (TS) is a challenging health care condition requiring spine surgery, and predicting the probabilities of prolonged postoperative length of stay (PLOS) can aid in effective management, especially with the increasing number of aging patients. This study aimed to develop and validate an interpretable nomogram for risk stratification and prediction of prolonged PLOS for TS patients after surgery, utilizing SHapley Additive exPlanations (SHAP) for model interpretation.</p><p><strong>Methods: </strong>This retrospective analysis comprised data of 580 TS patients that were hospitalized between January 2016 and December 2022. Prolonged PLOS was defined as hospitalization exceeding the 75th percentile. Factors associated with an increased risk of prolonged PLOS were identified using the Least Absolute Shrinkage and Selection Operator (LASSO) method and incorporated into a multivariable logistic regression model. SHAP values were generated to explain the contribution of each variable in predicting prolonged PLOS. Based on the identified risk variables, a nomogram was constructed using the SHAP values to represent each factor's contribution to the final outcome. The nomogram's effectiveness was assessed using calibration plots, discrimination analysis, and decision curve analysis.</p><p><strong>Results: </strong>Among 580 patients, 127 had prolonged postoperative length of stay (PLOS > 11 days), while 453 had normal stays (≤ 11 days). The developed nomogram incorporated 7 significant risk factors along with their corresponding SHAP values, which are C-reactive protein (CRP), multiple sections, CT-vertebral destruction, MRI-epidural abscess, transfusions, blood loss and postoperative drainage (Drainage volume on the first day after surgery). The calibration graphs showed that the expected and observed probability of prolonged PLOS was in close agreement. Discrimination analysis yielded an area under the curve (AUC) of 0.867 (95% CI: 0.828-0.908) in the training set, indicating good predictive performance. Decision curve analysis confirmed the clinical utility of the nomogram in risk stratification and treatment decision-making.</p><p><strong>Conclusions: </strong>By utilizing SHAP for model interpretation, this study provides an interpretable nomogram for assessing the possibility of extended PLOS in TS patients. The inclusion of SHAP values allows clinicians to understand the contribution of each variable in the prediction, thereby increasing transparency and aiding in the decision-making process. This nomogram has the potential to contribute to improved patient management and optimization of resource allocation. Prospective validation studies are recommended to further evaluate its effectiveness in clinical practice.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"539"},"PeriodicalIF":2.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between temporomandibular disorders and kinematics of the sacroiliac joint: a 3D motion analysis study.","authors":"Leila Rahnama, Ahmad Bahramian Parchekouhi, Noureddin Karimi, Ali Barzegar","doi":"10.1186/s12891-025-08717-6","DOIUrl":"10.1186/s12891-025-08717-6","url":null,"abstract":"<p><strong>Background: </strong>Temporomandibular disorders (TMDs) have been the focus of many studies, but the relationship between TMDs and other body segments, such as the pelvis, remains controversial. This study aimed to investigate the relationship between TMD and kinematics of the sacroiliac joint.</p><p><strong>Method: </strong>Twenty participants with chronic TMD and 20 healthy individuals were included in this study. The temporomandibular joint range of motion, pain intensity, and TMD severity were documented. The three-dimensional kinematics of the sacroiliac joint were recorded during a trunk flexion task using a motion analysis system and MATLAB software.</p><p><strong>Results: </strong>The severity of TMD had a significant association with pain intensity in the patient group. At the starting position (before forward flexion of the trunk), we found significant differences in the linear and angular positions of the sacrum relative to the ilium in the sagittal plane and around the frontal axis on both sides between groups.</p><p><strong>Conclusion: </strong>Our results indicated significant differences in some parameters between the healthy and TMD groups, emphasizing altered sacroiliac joint kinematics associated with TMD. This study contributes to the ongoing discussion about the relationship between TMD and other areas of the body and highlights the importance of further research in this area.</p><p><strong>Trial registration: </strong>Clinical Trial number is not applicable.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"540"},"PeriodicalIF":2.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracing neurodevelopment and growth pattern in six-year-old children with idiopathic clubfoot: a national cohort study.","authors":"Sung Tan Cho, Ha-Na Yoo, Simho Jeong, Ju Hee Kim, Eun Kyo Ha, Bo Eun Han, Wongthawat Liawrungrueang, Man Yong Han, Soonchul Lee","doi":"10.1186/s12891-025-08810-w","DOIUrl":"10.1186/s12891-025-08810-w","url":null,"abstract":"<p><strong>Study design: </strong>Population-based retrospective cohort study.</p><p><strong>Objectives: </strong>The developmental impact of idiopathic clubfoot on children remains underexplored. This study investigates neurodevelopment and physical growth in children with idiopathic clubfoot up to age six.</p><p><strong>Methods: </strong>This population-based retrospective cohort study was conducted in South Korea (2009-2019) using linked data from National Health Insurance Service. The cohort included children diagnosed with idiopathic clubfoot and 1:10 exact match of healthy control children. Neurodevelopmental assessments were conducted using the validated Korean Developmental Screening Test, which covers six domains: gross motor skills, fine motor skills, cognition, language, social skills, and self-regulation, for children aged 42-71 months. Secondary outcomes measured were height and body mass index (BMI) Z-score during the same period.</p><p><strong>Results: </strong>The cohort comprised 484 children with idiopathic clubfoot and 4,840 matched healthy control children. Children with clubfoot had a higher rate of premature birth (7.44% vs. 3.66%, p < 0.0001) and lower birth weight (3.08 ± 0.59 kg vs. 3.20 ± 0.46 kg, p < 0.0001) compared to the healthy control children. In-depth evaluation of all six neurodevelopmental domains showed significant differences in children with clubfoot (overall aOR, 3.671; 95% CI, 2.463-5.471). Children with clubfoot showed a significant height delay (Z score, -1.63 below), but no BMI difference was noted.</p><p><strong>Conclusions: </strong>Children with idiopathic clubfoot demonstrated increased risk of neurodevelopmental delays and reduced height compared to their peers. These findings underscore the importance of early recognition and ongoing monitoring by parents and pediatricians.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"542"},"PeriodicalIF":2.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors for residual back pain after percutaneous vertebral augmentation in osteoporotic vertebral compression fracture patients: a systematic review and meta-analysis.","authors":"Bairu Chen, Jie He, Jingli Tang, Xiaoqin Liu","doi":"10.1186/s12891-025-08731-8","DOIUrl":"10.1186/s12891-025-08731-8","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to evaluate the occurrence and potential causes of residual back pain following percutaneous vertebral augmentation (percutaneous vertebroplasty/percutaneous kyphoplasty) in patients with osteoporotic vertebral compression fracture.</p><p><strong>Methods: </strong>To investigate the occurrence and risk factors of residual back pain, a comprehensive search was conducted in several databases including PubMed, Web of Science, Embase, Cochrane Library, China Knowledge Resource Integrated Database (CNKI), Chinese Biomedical Database (CBM), Wanfang Database, and Weipu Database (VIP) from the inception until October 10, 2023. After applying inclusion and exclusion criteria, the articles were filtered. The quality of the included studies was assessed independently by two investigators. Stata18.0 was used for the meta-analysis.</p><p><strong>Results: </strong>In total, 1900 articles were screened, and data from 13 studies was used in the meta-analysis. After percutaneous vertebral augmentation for patients with osteoporotic vertebral compression fracture, the occurrence of residual back pain was 19% (95% confidence interval 14-23%, I ² = 96.6%, P < 0.001). The risk of residual back pain was increased by lower bone mineral density (OR = 5.56, 95%CI 3.83-8.09, P < 0.001), presence of intravertebral vacuum cleft (OR = 3.52, 95% CI 2.07-6.01, P < 0.001), unsatisfactory distribution of bone cement (OR = 2.79, 95% CI 2.05-3.81, P < 0.001), occurrence of recurrent fracture (OR = 4.34, 95%CI 2.75-6.84, P < 0.001), thoracolumbar fascia injury (OR = 3.21, 95% CI 1.91-5.40, P < 0.001), inadequate volume of bone cement injection (OR = 5.58, 95% CI 1.97-15.84, P = 0.001), and nonunion of fracture (OR = 4.67, 95%CI 2.00-10.88, P < 0.001). Furthermore, the rate of recovery in vertebral height (OR = 0.52 (95%CI 0.32-0.85, P = 0.009) may serve as a protective element.</p><p><strong>Conclusion: </strong>There was a 19% prevalence of residual back pain among osteoporotic vertebral compression fracture patients with percutaneous vertebral augmentation. Patients with osteoporotic vertebral compression fracture may experience residual back pain after percutaneous vertebral augmentation due to a combination of intravertebral vacuum cleft, unsatisfactory bone cement distribution, recurrent fracture, thoracolumbar fascia injury, insufficient bone cement injection volume, fracture nonunion, bone mineral density, and vertebral height recovery rate.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"541"},"PeriodicalIF":2.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of intraarticular human umbilical cord mesenchymal stem cells transplantation on cartilage degradation and matrix metalloproteinases in OA rat model.","authors":"Yanqun Li, Qipeng Han, Yansha Chen, Wenlong Huang, Yanqing Chen, Zhihuang Wu, Fengming Tan, Muyun Liu, Jiangying Zou","doi":"10.1186/s12891-025-08797-4","DOIUrl":"10.1186/s12891-025-08797-4","url":null,"abstract":"<p><strong>Background: </strong>Osteoarthritis (OA) is a common cause of disability around the world, but the pathophysiology is still poorly understood. The study sought to investigate the effects of umbilical cord mesenchymal stem cells (UC-MSCs) injection in OA, with a focus on cartilage degradation.</p><p><strong>Methods: </strong>The serum matrix metalloproteinase (MMPs) and a disintegrin and metalloprotease domains with thrombospondins motifs (ADAMTS) levels in OA patients were examined using ELISA. The levels of MMPs and ADAMTS in peripheral blood mononuclear cells (PBMCs) following co-cultured with UC-MSC were determined by ELISA. The anterior cruciate ligament transection (ACLT) surgery was performed on the knee joints of a rat OA model, followed by intra-articular injection of UC-MSCs at 4 weeks and 8 weeks after surgery, and the changes of the severity of OA, tibiofemoral cartilage, and subchondral bone were observed by Safranin-O staining, hematoxylin and eosin (H&E) staining, and micro-CT imaging.</p><p><strong>Results: </strong>OA patients showed the higher protein levels of MMP2, 9, 13, ADAMTS4 and 5 than healthy controls. Furthermore, in vitro incubation of PBMC derived from OA patients with UC-MSCs down-regulated the protein expression of these proteases. Positive correlations were observed between serum MMP9 levels and high-sensitivity C-reactive protein (hsCRP) in OA patients, while a negative correlation between serum MMP13 and Alkaline phosphatase (ALKP) was observed in these patients. There was a negative correlation between OA patients' serum ADAMTS 4 and Lipoprotein (a)(Lp(a)). Western blotting and immunohistostaining were applied to assess the protein levels of matrix metalloproteinases and ADAMTSs in rat knee joints and these protein levels were significantly decreased in the UC-MSC intra-articular injection group. Micro-CT results showed in the OA rat model human UC-MSCs treatment alleviated the destruction of the tibial subchondral bone.</p><p><strong>Conclusion: </strong>UC-MSCs decreased the level of several matrix proteases, slowing the progression of OA formation in rats. Our findings suggested that matrix metalloproteinases and ADAMTSs play a role in OA progression, UC-MSC exerted beneficial therapeutic effects on OA rat model by reducing the levels of these matrix metalloproteinases and ADAMTSs.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"538"},"PeriodicalIF":2.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}