BMC Musculoskeletal Disorders最新文献

{"title":"Accumulation of lipids after acute direct and indirect traumatic injuries in male and female mice.","authors":"Angela S Bruzina, Braydon A Crum, Christiana J Raymond-Pope, Jarrod A Call, Sarah M Greising","doi":"10.1186/s12891-025-09207-5","DOIUrl":"10.1186/s12891-025-09207-5","url":null,"abstract":"<p><strong>Background: </strong>Adipose infiltration and lipid droplet accumulation are implicated in metabolic diseases and are known to limit skeletal muscle repair and regeneration. However, their role in skeletal muscle injury, particularly volumetric muscle loss (VML), remains unclear. We aimed to characterize early lipid and adipokine responses following direct (i.e., VML) and indirect (i.e., denervation) traumatic injuries.</p><p><strong>Methods: </strong>Adult male and female C57Bl/6J mice (n = 36) were randomized to VML injury to the posterior hindlimb, tibial nerve denervation, or remained injury Naïve. Three days post, in vivo muscle function was assessed. Serum and gastrocnemius muscle tissue were assessed for histological and biochemical analyses.</p><p><strong>Results: </strong>A decrease in total myofiber number occurred post-VML with a reduction in force and increased fatigue. Lipid droplet-associated proteins displayed injury- and myofiber type-specific changes, with VML exhibiting accumulation of perilipin 5 localized to the injury site. Lipid droplets in the muscle remaining were significantly greater post-VML compared to denervation. The pro-inflammatory adipokine IL-6 and growth factor IGF-1 were markedly increased in the muscle remaining post-VML, while circulating metabolic regulators, adiponectin and leptin, were suppressed.</p><p><strong>Conclusions: </strong>These findings underscore lipid droplet dynamics and adipokine signaling disruptions following indirect and direct traumatic injuries in a preclinical model. Future work should be done to explore aspects of lipid droplet regulation temporally following skeletal muscle injuries, as early accumulation may suggest an additional etiology in the pathological sequelae of injury.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"932"},"PeriodicalIF":2.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of glutaminase 1 inhibitor on rotator cuff derived cells: a preliminary report in 12 patients.","authors":"Tatsuo Kato, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Shintaro Mukohara, Tomoya Yoshikawa, Issei Shinohara, Takahiro Furukawa, Shuya Tanaka, Masaya Kusunose, Yuichi Hoshino, Takehiko Matsushita, Tomoyuki Matsumoto, Ryosuke Kuroda","doi":"10.1186/s12891-025-09105-w","DOIUrl":"10.1186/s12891-025-09105-w","url":null,"abstract":"<p><strong>Background: </strong>Glutaminase 1 (GLS1) degrades glutamate into glutamine and ammonia, and is required for the survival of senescent human cells. GLS1 inhibitors contribute to the improvement of various pathological conditions associated with aging. Rotator cuff tears (RCT) increase with age, and recently the Stump classification has been proposed to evaluate the fragility of the torn rotator cuff site, with Type 3 being the most fragile and a high risk of re-tear after rotator cuff repair surgery. We hypothesized that GLS1 expression is upregulated in the degenerated rotator cuff and that GLS1 inhibitors would improve rotator cuff degeneration. In this study, we evaluated the effects of GLS1 inhibitors on human rotator cuff-derived cells.</p><p><strong>Methods: </strong>Twelve patients who underwent surgery for RCT were included in this study. Rotator cuff tissue was harvested during arthroscopic repair for tissue and cell evaluation. Tissue evaluation involved quantitative assessment of mRNA expression of GLS1 using real-time PCR (qPCR) and immunostaining. Rotator cuff-derived cells were isolated and cultured, divided into four groups: (1) Control group (without IL-1β and GLS1 inhibitor), (2) IL-1β(-)/GLS1 inhibitor(+), (3) IL-1β(+)/GLS1 inhibitor(-), (4) IL-1β(+)/GLS1 inhibitor(+). Cell viability was evaluated by WST assay and mRNA expression was evaluated by qPCR at 48 h after treatment. The expression of p16 and Scleraxis (SCX) was also evaluated by fluorescent immunostaining.</p><p><strong>Results: </strong>Tissue evaluation showed significantly higher expression of GLS1 in Stump classification Type 3. Cell viability was significantly decreased by IL-1β loading and increased by the GLS1 inhibitor. The mRNA expression levels of GLS1, IL-6, p16 and p21 were decreased by the GLS1 inhibitor. The mRNA expression of the tendon markers, type 1 collagen, Mohawk and SCX were increased by the GLS1 inhibitor. Immunostaining revealed that the GLS1 inhibitor decreased p16 expression and increased SCX expression.</p><p><strong>Conclusions: </strong>This study showed that GLS1 was upregulated in the degenerated rotator cuff, and that the administration of a GLS1 inhibitor decreased inflammation and aging markers while increasing cell viability and tendon markers in rotator cuff-derived cells. These results indicate that GLS1 inhibitors exert anti-inflammatory effects in rotator cuff tears, prevent age-related degeneration of the rotator cuff, and promote tendon repair.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"935"},"PeriodicalIF":2.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arthroscopic repair of the anterior talofibular ligament with retrograde drilling and allograft bone grafting for chronic lateral ankle instability with hepple stage V osteochondral lesions of the talus.","authors":"Shu Chen, Yaguang Han, Lei Zhang, Jinhui Peng, Shuai Yuan, Haobo Li, Qirong Qian, Jun Zhu, Yiqin Zhou","doi":"10.1186/s12891-025-09181-y","DOIUrl":"10.1186/s12891-025-09181-y","url":null,"abstract":"<p><strong>Background: </strong>Chronic lateral ankle instability (CLAI) often arises from inadequately managed injuries to the lateral collateral ligaments, potentially leading to osteochondral lesions of the talus (OLT) and subsequent osteoarthritis. Hepple Stage V OLT, characterized by subchondral cysts, presents a significant therapeutic challenge. This study aimed to evaluate the efficacy of arthroscopic anterior talofibular ligament (ATFL) repair combined with retrograde drilling and allograft bone grafting in patients with CLAI and Hepple Stage V OLT with an intact talar articular surface.</p><p><strong>Methods: </strong>This retrospective, small-sample exploratory study included 12 patients (ten men; median age: 35 years) who underwent arthroscopic treatment (between January 2020 and December 2022) for chronic lateral ankle instability with subchondral cysts, specifically Hepple Stage V OLT cases with an intact talar articular surface, after failing non-surgical interventions. The ATFL was repaired using the all-inside Internal Brace (IB) augmentation with the arthroscopic modified Broström operation. Treatment for OLT involved simultaneous retrograde drilling and allograft bone grafting. The median follow-up duration was 24 months (range: 20-35 months). The improvement of postoperative ankle pain was assessed using the Visual Analogue Scale (VAS), and the improvement of ankle function was evaluated using the American Orthopedic Foot ༆ Ankle Society (AOFAS) score and Foot༆Ankle Outcome Score (FAOS). Radiographic assessments were conducted at a minimum of 12 months postoperatively.</p><p><strong>Results: </strong>All 12 patients (12 ankles; 100%) returned for clinical and radiological follow-up at an average of 24 months (20-35 months) postoperatively. Subjective improvement was reported after arthroscopic surgery. The median AOFAS score demonstrated a substantial improvement from 67 preoperatively (range: 58-70) to 94 at the final follow-up (range: 90-98), with P < 0.05. Similarly, The FAOS score improved from 65 preoperatively (range: 58-75) to 91 at the final follow-up (range: 89-97), with P < 0.05. Radiographic follow-up results indicated satisfactory healing of the ATFL and favorable bone ingrowth post-subchondral cyst bone grafting.</p><p><strong>Conclusion: </strong>Arthroscopic ATFL repair combined with retrograde drilling and allograft bone grafting yields favorable clinical and radiographic outcomes in patients with CLAI and Hepple Stage V OLT. This integrated approach addresses both ligament instability and subchondral cyst pathology, potentially delaying the progression of osteoarthritis.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"930"},"PeriodicalIF":2.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of combined calcium and vitamin D supplementation on bone mineral density and fracture risk in postmenopausal women with osteoporosis: a systematic review and meta-analysis of randomized controlled trials.","authors":"Bo Cong, Haiguang Zhang","doi":"10.1186/s12891-025-09089-7","DOIUrl":"10.1186/s12891-025-09089-7","url":null,"abstract":"","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"928"},"PeriodicalIF":2.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical study of T lymphocyte subsets and several biological indicators in children with transient synovitis.","authors":"Yuchi Wang, Dezhao Liu, Lijia Pan, Yaoyao Guo, Shiyuan Hu, Da Ma, Xiaoxuan Zhang, Fengqi Gao","doi":"10.1186/s12891-025-09211-9","DOIUrl":"10.1186/s12891-025-09211-9","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to analyze T lymphocyte subsets and several biological indicators in children with transient synovitis (TS) to provide insights for subsequent diagnosis and treatment.</p><p><strong>Methods: </strong>We retrospectively studied 126 patients admitted to Changchun Children's Hospital from May 2020 to August 2023 with suspected acute TS or bone and joint infections (BJIs). The study comprised two parts: (1) description and analysis of clinical and laboratory features of all patients under 16 years old ; (2) comparison of laboratory data between children with TS and a control group of children undergoing elective surgery. Univariate analysis was used to determine the significant differences. Linear regression analysis was used to analyze the correlation between the variables in the study.</p><p><strong>Results: </strong>Among the 126 patients, 121 were diagnosed with TS and 5 with BJIs. We analyzed the clinical and laboratory features of these children. Most patients achieved remission after treatment. In children with transient synovitis of the hip (TSH), the amount of joint effusion was negatively correlated with the CD4 + T lymphocyte count. Median IL-6 levels were significantly higher in TSH children with a preceding upper respiratory infection (URI) compared to those without.</p><p><strong>Conclusions: </strong>Alterations in T lymphocyte subsets, particularly CD4 + count, may be associated with joint effusion volume in TSH. Detection of T lymphocyte subsets and several specific biomarkers (IL-6, TNF-α, IL-2) reflects the changes of immune status in children with TS, potentially aiding clinical assessment.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"936"},"PeriodicalIF":2.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limited effects of non-steroidal anti-inflammatory drugs (NSAIDs) on imaging outcomes in osteoarthritis: observational data from the osteoarthritis initiative (OAI).","authors":"Virginie Kreutzinger, Katharina Ziegeler, Johanna Luitjens, Gabby B Joseph, John Lynch, Nancy E Lane, Charles E McCulloch, Michael Nevitt, Thomas M Link","doi":"10.1186/s12891-025-09172-z","DOIUrl":"10.1186/s12891-025-09172-z","url":null,"abstract":"<p><strong>Background: </strong>Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed for pain relief in osteoarthritis (OA), and their anti-inflammatory effects may play a role in shaping the disease course. The aim of this investigation was to examine the relationship between new use of prescription NSAIDs and changes in imaging biomarkers of synovitis in the knee, and to evaluate the association of NSAID use with structural cartilage damage over a period of four years.</p><p><strong>Methods: </strong>Applying a new user design to identify treatment effects in observational data, we selected participants from the Osteoarthritis Initiative (OAI) who were prescribed regular, oral NSAID medication between baseline and 48 months follow-up and who had available 3T MRIs of the right knee with whole-organ magnetic resonance imaging score (WORMS) readings as well as semi-quantitative assessments of synovitis for both timepoints. These individuals were frequency-matched with non-NSAID users matching for age, gender, body mass index (BMI), baseline Kellgren & Lawrence (KL) grade, Western Ontario and McMaster Universities Osteoarthritis (WOMAC) scores, and for the presence of an inflammatory imaging phenotype at baseline. Ordinal regression analyses and marginal estimated means were used to determine the effect of NSAID use on structural imaging outcomes, controlling for age, gender, BMI, and non-prescription NSAID use.</p><p><strong>Results: </strong>In this longitudinal analysis over 48 months, 142 individuals met prespecified criteria for new NSAID exposure, and 707 matched controls were identified. Regression analyses did not show a significant association between new NSAID use and changes in effusion-synovitis, Hoffa's synovitis, or synovial proliferation scores over 4 years. However, NSAID users showed a significantly slower progression of cartilage lesions as measured by WORMS grading; this effect was marginally more pronounced in participants with an inflammatory imaging phenotype (beta - 0.92; p = 0.043) than in the population overall (beta - 0.48; p = 0.020).</p><p><strong>Conclusion: </strong>New NSAID use was not associated with MRI-detected synovitis over 4 years but had a modest association with reduced structural cartilage damage progression. This effect was more pronounced in individuals with an inflammatory imaging phenotype.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"939"},"PeriodicalIF":2.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of radial extracorporeal shock wave therapy (rESWT) in plantar fasciitis: a 12 months randomised controlled trial in a Tunisian rehabilitation department.","authors":"Loubiri Ines, Moncer Rihab, Bhiri Sana, Layouni Saoussen, Gaddour Mariem, Frigui Sinene, Jemni Sonia","doi":"10.1186/s12891-025-09103-y","DOIUrl":"10.1186/s12891-025-09103-y","url":null,"abstract":"<p><strong>Background: </strong>Current management strategies for plantar fasciitis primarily involve conservative treatments. However, the overall effectiveness of extracorporeal shock wave therapy (ESWT) as a specific intervention for this condition has been a subject of ongoing debate in the medical community and its long term efficacy remains controversial. This study's objective is to assess the effectiveness of extracorporeal radial shock wave therapy (rESWT) for treating plantar fasciitis treatment compared to physiotherapy combined with ultrasound sessions and to screen for foot disorders implementing baropodometry, in a Tunisian tertiary care rehabilitation department.</p><p><strong>Methods: </strong>Patients who presented to the rehabilitation department between November 2022 and November 2023 with Plantar Fasciitis were randomly assigned to the rESWT and the Physiotherapy combined to ultrasound groups. The diagnosis of PF was confirmed by physical examination. X-ray radiography was used to exclude a fracture of the calcaneus.</p><p><strong>Results: </strong>Our study included 129 patients diagnosed with plantar fasciitis (PF), who were randomly allocated into two groups: 66 participants received radial extracorporeal shockwave therapy (rESWT), and 63 received physiotherapy combined with ultrasound therapy. The average age of these patients was 50.33 years (SD 10). The majority of participants were female, accounting for 101 individuals (78%). The average Body Mass Index (BMI) across the study group was 29.2 kg/m2. Regarding lower limb conditions, pes cavus (high arches) was the most common, observed in 58 participants (45%), followed by pes planus (low arches) in 47 participants (36%).Both treatment groups showed a significant decrease in Visual Analogue Scale (VAS) scores across all follow-up periods (p<0.001). However, no significant difference was found in the mean VAS scores between the two groups at any point after treatment.</p><p><strong>Conclusion: </strong>Both protocols (rESWT and physiotherapy combined to ultrasound) were effective for improving morning pain at short term and midterm follow-up periods. Foot disorders should be initially evaluated and considered while treating.</p><p><strong>Trial registration: </strong>This trial is officially registered with the Pan African Clinical Trial Registry under the registration number PACTR202308802969500 first registered on (24/08/2023).</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"938"},"PeriodicalIF":2.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MR arthrographic analysis of labral and tendinous lesions in patients with shoulder avulsion injury.","authors":"Yusuf Yahsi, Hayri Ogul, Rodi Ertogrul, Zakir Sakci, Yusuf Sulek, Mecit Kantarci","doi":"10.1186/s12891-025-09217-3","DOIUrl":"10.1186/s12891-025-09217-3","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the frequency and characteristics of specific labral lesions (SLAP and Bankart) and associated tendinous injuries in patients with avulsion fractures of the shoulder using magnetic resonance (MR) arthrography and to investigate their potential clinical implications.</p><p><strong>Methods: </strong>A retrospective review was performed on 850 shoulder MR arthrograms retrieved from our institutional PACS database.The study comprised a total of 35 patients with confirmed avulsion fractures and 30 age- and sex-matched controls. . All patients received both conventional MR imaging and 3D volumetric MR arthrography sequences. The evaluation focused on labral lesions (SLAP, Bankart), rotator cuff injuries and biceps tendon pathology which were systematically evaluated by two experienced radiologists.</p><p><strong>Results: </strong>The avulsion fracture of the greater tuberosity was the most commonly observed, accounting for 60% of cases. Labral pathology was considerably more prevalent among the patient cohort (51.4%) compared to the control group (23.3%) (p=0.039). Superior labrum anterior to posterior (SLAP) lesions were the most frequently identified labral abnormalities, and were significantly more common than both Bankart lesions (17.1%) and Bankart variant lesions (2.9%) (p=0.015). Patients presenting with fractures of the lesser tuberosity demonstrated a notably higher incidence of combined rotator cuff and biceps tendon pathology (77.8%) in contrast to those with greater tuberosity fractures (14.3%) (p=0.002).</p><p><strong>Conclusions: </strong>The research underscores a robust link between avulsion fractures and superior labral injuries, especially SLAP lesions. Moreover, there was a significant correlation between lesser tuberosity fractures and extensive tendinous pathology, indicating a greater degree of biomechanical compromise. These results highlight the critical role of MR arthrography in identifying concurrent labral and tendinous injuries that could affect clinical decision-making.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"933"},"PeriodicalIF":2.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative analysis of the efficacy of modified double-bundle suspension fixation versus single-bundle suspension fixation for acromioclavicular joint dislocation treatment.","authors":"Dan Wen, Pei Zhang, Yaojia Lu, Sheng Meng, Wenyong Fei","doi":"10.1186/s12891-025-09214-6","DOIUrl":"10.1186/s12891-025-09214-6","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to compare clinical and radiologic outcomes between modified double-bundle suspension fixation and single-bundle suspension fixation for the treatment of acute acromioclavicular joint (ACJ) dislocation.</p><p><strong>Method: </strong>A retrospective analysis was performed on the clinical data of 68 patients with ACJ dislocation treated in the orthopedics department of our hospital between May 2020 and May 2024. Patients were categorized into two groups according to their surgical techniques: 30 patients received the modified double-bundle suspension fixation technique (MDB group), while 38 patients underwent the traditional single-bundle suspension fixation technique (SB group). The study statistically analyzed and compared clinical baseline characteristics, surgical parameters, Visual Analogue Scale (VAS); scores, Constant-Murley Shoulder Function Score (Constant-Murley score). On the plain radiograph, the coracoclavicular (CC) interval ratio (CCIR)was measured to evaluate maintenance of CC interval fixation. Postoperative complications, including reduction failure, titanium plate slippage, or bone resorption around the titanium plate, were also documented.</p><p><strong>Result: </strong>No statistically significant differences were observed in preoperative data between the two groups (P > 0.05). The MDB group showed longer average surgical duration compared to the SB group (P < 0.05), while no significant differences were found in incision length, intraoperative blood loss, or postoperative hospitalization duration (P > 0.05). Postoperatively, at day 2, 3 months, 6 months, and the final follow-up, the MDB group demonstrated significantly better VAS scores, Constant-Murley scores, and CCIR measurements than the SB group (P < 0.05). During the follow-up period, no complications were observed in the MDB group, whereas the SB group experienced 8 cases (8/38) of complications, including 6 cases of lost reduction, 1 case of titanium plate displacement, and 1 case of bone dissolution. According to the classification, one case was classified as type Ⅲ, while the remaining cases were classified as type IV/V.</p><p><strong>Conclusion: </strong>Compared with single-bundle fixation, the modified double-bundle fixation technique for ACJ dislocation demonstrates significant advantages in preventing postoperative loss of reduction, particularly in cases of high-grade ACJ. Additionally, it is associated with reduced postoperative pain and superior recovery of shoulder joint function. Moreover, compared with existing double- bundle fixation techniques, this surgical approach exhibits a diminished suture-bone abrasion between the suture and bone tunnel, which is worth further study.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"934"},"PeriodicalIF":2.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of muscle activation and proprioception during landing at different angles between individuals with chronic ankle instability and healthy controls.","authors":"Serkan Uzlasir, Beyza Tayfur, Erhan Işıkdemir, Abdulhamit Tayfur","doi":"10.1186/s12891-025-09212-8","DOIUrl":"10.1186/s12891-025-09212-8","url":null,"abstract":"<p><strong>Background: </strong>Chronic Ankle Instability (CAI) is associated with proprioceptive deficits and altered neuromuscular control, yet limited studies have examined these factors concurrently during functional tasks like jump-landing.</p><p><strong>Methods: </strong>A total of 44 participants, including 21 healthy individuals and 23 with CAI, participated in a crossover experimental study. An EMG system (Noraxon, USA) was used bilaterally to assess muscle activation of the key muscles involved in ankle movement during jump-landing activities. Specifically, medial gastrocnemius (MG) and tibialis anterior (TA) muscles were evaluated. To identify differences in The Ankle Inversion Discrimination Apparatus for Landing (AIDAL) parameters between groups, an independent samples t-test was conducted. Linear mixed modeling with repeated measures was performed to analyze muscle activation differences during jump-landing at different angles.</p><p><strong>Results: </strong>Individuals with CAI exhibited significantly lower AIDAL slope estimates compared to healthy controls, with a moderate effect size (p < 0.001, d = 0.78). In the EMG results, no statistically significant difference was observed between the CAI group and healthy controls (p = 0.431) for TA and (p = 0.699) for MG. Statistically significant differences were found in the activation of the MG muscle between 10^o and 14^o (p = 0.009), between 12^o and 16^o (p = 0.041) and between 14^o and 16^o (p = 0.005).</p><p><strong>Conclusion: </strong>This study indicates that individuals with CAI experience impaired proprioception compared to healthy individuals, while showing no notable differences in key muscle activation patterns. It highlights the necessity of rehabilitation strategies focused on proprioception.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"929"},"PeriodicalIF":2.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}