N Hesse, D Strack, J F Rischewski, F T Gassert, A Kufner, T Urban, M E Lochschmidt, B J Schwaiger, C Braun, D P Mueller, D Pfeiffer, T Baum, K Subburaj, F Pfeiffer, A S Gersing
{"title":"人腰椎骨质疏松和健康椎体的有限元断裂载荷分析和暗场x线成像。","authors":"N Hesse, D Strack, J F Rischewski, F T Gassert, A Kufner, T Urban, M E Lochschmidt, B J Schwaiger, C Braun, D P Mueller, D Pfeiffer, T Baum, K Subburaj, F Pfeiffer, A S Gersing","doi":"10.1186/s12891-025-08709-6","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the association of measurements from a clinical X-ray dark-field prototype system and CT-based finite element analysis (FEA) in lumbar spine specimens.</p><p><strong>Materials and methods: </strong>In this prospective study, human cadaveric spine specimens (L2 to L4) were examined using a clinical prototype for dark-field radiography, yielding both attenuation and dark-field images. Specimens were scanned in vertical and horizontal positions. Volumetric bone mineral density (BMD) values were derived from quantitative CT measurements. Bone segmentation masks derived from CT-images were used for FEA-estimated fracture load (FL) calculations. FEA-estimated FL, dark-field, and attenuation signals were compared between osteoporotic/osteopenic (BMD < 120 mg/cm<sup>3</sup>) and non-osteoporotic/osteopenic specimens using the paired t-test and the Wilcoxon Mann-Whitney U test. Associations were tested using Spearman correlation.</p><p><strong>Results: </strong>Fifty-nine vertebrae from 20 lumbar spine specimens (mean age, 73 years ± 13; 11 women) were studied. FEA-estimated FL correlated with BMD (r = 0.75, p < .001) and was significantly lower in osteoporotic/osteopenic vertebrae (1222 ± 566 vs. 2880 ± 1182, p < .001). Dark-field and attenuation signals were positively correlated with FEA-estimated FL, in both vertical (r<sub>darkfield</sub> = 0.64, p < .001, r<sub>attenuation</sub> = 0.82, p < .001) and horizontal position (r<sub>darkfield</sub> = 0.55, p < .001, r<sub>attenuation</sub> = 0.81, p < .001).</p><p><strong>Conclusion: </strong>Dark-field and attenuation signals assessed using a clinical X-ray dark-field system significantly correlated with FEA-estimated FL in human spine specimens with and without osteoporosis/osteopenia. Dark-Field imaging may complement existing assessment methods for bone strength as a dose-efficient, accessible tool.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":"26 1","pages":"545"},"PeriodicalIF":2.2000,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131393/pdf/","citationCount":"0","resultStr":"{\"title\":\"Finite element fracture load analysis and dark-field X-ray imaging of osteoporotic and healthy vertebrae in human lumbar spine specimens.\",\"authors\":\"N Hesse, D Strack, J F Rischewski, F T Gassert, A Kufner, T Urban, M E Lochschmidt, B J Schwaiger, C Braun, D P Mueller, D Pfeiffer, T Baum, K Subburaj, F Pfeiffer, A S Gersing\",\"doi\":\"10.1186/s12891-025-08709-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>This study investigated the association of measurements from a clinical X-ray dark-field prototype system and CT-based finite element analysis (FEA) in lumbar spine specimens.</p><p><strong>Materials and methods: </strong>In this prospective study, human cadaveric spine specimens (L2 to L4) were examined using a clinical prototype for dark-field radiography, yielding both attenuation and dark-field images. Specimens were scanned in vertical and horizontal positions. Volumetric bone mineral density (BMD) values were derived from quantitative CT measurements. Bone segmentation masks derived from CT-images were used for FEA-estimated fracture load (FL) calculations. FEA-estimated FL, dark-field, and attenuation signals were compared between osteoporotic/osteopenic (BMD < 120 mg/cm<sup>3</sup>) and non-osteoporotic/osteopenic specimens using the paired t-test and the Wilcoxon Mann-Whitney U test. Associations were tested using Spearman correlation.</p><p><strong>Results: </strong>Fifty-nine vertebrae from 20 lumbar spine specimens (mean age, 73 years ± 13; 11 women) were studied. FEA-estimated FL correlated with BMD (r = 0.75, p < .001) and was significantly lower in osteoporotic/osteopenic vertebrae (1222 ± 566 vs. 2880 ± 1182, p < .001). Dark-field and attenuation signals were positively correlated with FEA-estimated FL, in both vertical (r<sub>darkfield</sub> = 0.64, p < .001, r<sub>attenuation</sub> = 0.82, p < .001) and horizontal position (r<sub>darkfield</sub> = 0.55, p < .001, r<sub>attenuation</sub> = 0.81, p < .001).</p><p><strong>Conclusion: </strong>Dark-field and attenuation signals assessed using a clinical X-ray dark-field system significantly correlated with FEA-estimated FL in human spine specimens with and without osteoporosis/osteopenia. Dark-Field imaging may complement existing assessment methods for bone strength as a dose-efficient, accessible tool.</p>\",\"PeriodicalId\":9189,\"journal\":{\"name\":\"BMC Musculoskeletal Disorders\",\"volume\":\"26 1\",\"pages\":\"545\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-06-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131393/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMC Musculoskeletal Disorders\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12891-025-08709-6\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ORTHOPEDICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Musculoskeletal Disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12891-025-08709-6","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ORTHOPEDICS","Score":null,"Total":0}
Finite element fracture load analysis and dark-field X-ray imaging of osteoporotic and healthy vertebrae in human lumbar spine specimens.
Purpose: This study investigated the association of measurements from a clinical X-ray dark-field prototype system and CT-based finite element analysis (FEA) in lumbar spine specimens.
Materials and methods: In this prospective study, human cadaveric spine specimens (L2 to L4) were examined using a clinical prototype for dark-field radiography, yielding both attenuation and dark-field images. Specimens were scanned in vertical and horizontal positions. Volumetric bone mineral density (BMD) values were derived from quantitative CT measurements. Bone segmentation masks derived from CT-images were used for FEA-estimated fracture load (FL) calculations. FEA-estimated FL, dark-field, and attenuation signals were compared between osteoporotic/osteopenic (BMD < 120 mg/cm3) and non-osteoporotic/osteopenic specimens using the paired t-test and the Wilcoxon Mann-Whitney U test. Associations were tested using Spearman correlation.
Results: Fifty-nine vertebrae from 20 lumbar spine specimens (mean age, 73 years ± 13; 11 women) were studied. FEA-estimated FL correlated with BMD (r = 0.75, p < .001) and was significantly lower in osteoporotic/osteopenic vertebrae (1222 ± 566 vs. 2880 ± 1182, p < .001). Dark-field and attenuation signals were positively correlated with FEA-estimated FL, in both vertical (rdarkfield = 0.64, p < .001, rattenuation = 0.82, p < .001) and horizontal position (rdarkfield = 0.55, p < .001, rattenuation = 0.81, p < .001).
Conclusion: Dark-field and attenuation signals assessed using a clinical X-ray dark-field system significantly correlated with FEA-estimated FL in human spine specimens with and without osteoporosis/osteopenia. Dark-Field imaging may complement existing assessment methods for bone strength as a dose-efficient, accessible tool.
期刊介绍：
BMC Musculoskeletal Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of musculoskeletal disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
The scope of the Journal covers research into rheumatic diseases where the primary focus relates specifically to a component(s) of the musculoskeletal system.
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