Finite element fracture load analysis and dark-field X-ray imaging of osteoporotic and healthy vertebrae in human lumbar spine specimens.

IF 2.2 3区医学 Q2 ORTHOPEDICS

BMC Musculoskeletal Disorders Pub Date : 2025-06-03 DOI:10.1186/s12891-025-08709-6

N Hesse, D Strack, J F Rischewski, F T Gassert, A Kufner, T Urban, M E Lochschmidt, B J Schwaiger, C Braun, D P Mueller, D Pfeiffer, T Baum, K Subburaj, F Pfeiffer, A S Gersing

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引用次数: 0

Abstract

Purpose: This study investigated the association of measurements from a clinical X-ray dark-field prototype system and CT-based finite element analysis (FEA) in lumbar spine specimens.

Materials and methods: In this prospective study, human cadaveric spine specimens (L2 to L4) were examined using a clinical prototype for dark-field radiography, yielding both attenuation and dark-field images. Specimens were scanned in vertical and horizontal positions. Volumetric bone mineral density (BMD) values were derived from quantitative CT measurements. Bone segmentation masks derived from CT-images were used for FEA-estimated fracture load (FL) calculations. FEA-estimated FL, dark-field, and attenuation signals were compared between osteoporotic/osteopenic (BMD < 120 mg/cm³) and non-osteoporotic/osteopenic specimens using the paired t-test and the Wilcoxon Mann-Whitney U test. Associations were tested using Spearman correlation.

Results: Fifty-nine vertebrae from 20 lumbar spine specimens (mean age, 73 years ± 13; 11 women) were studied. FEA-estimated FL correlated with BMD (r = 0.75, p < .001) and was significantly lower in osteoporotic/osteopenic vertebrae (1222 ± 566 vs. 2880 ± 1182, p < .001). Dark-field and attenuation signals were positively correlated with FEA-estimated FL, in both vertical (r_darkfield = 0.64, p < .001, r_attenuation = 0.82, p < .001) and horizontal position (r_darkfield = 0.55, p < .001, r_attenuation = 0.81, p < .001).

Conclusion: Dark-field and attenuation signals assessed using a clinical X-ray dark-field system significantly correlated with FEA-estimated FL in human spine specimens with and without osteoporosis/osteopenia. Dark-Field imaging may complement existing assessment methods for bone strength as a dose-efficient, accessible tool.

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人腰椎骨质疏松和健康椎体的有限元断裂载荷分析和暗场x线成像。

目的：本研究探讨了临床x射线暗场原型系统测量结果与基于ct的腰椎标本有限元分析（FEA）的关系。材料和方法：在这项前瞻性研究中，人类尸体脊柱标本（L2至L4）使用临床原型进行暗场x线摄影检查，产生衰减和暗场图像。标本在垂直和水平位置进行扫描。体积骨密度（BMD）值来源于定量CT测量。从ct图像中提取的骨分割掩模用于有限元估计骨折载荷（FL）的计算。使用配对t检验和Wilcoxon Mann-Whitney U检验比较骨质疏松/骨质减少（BMD 3）和非骨质疏松/骨质减少标本的fea估计的FL、暗场和衰减信号。使用Spearman相关检验关联。结果：20例腰椎标本59根椎骨(平均年龄73岁±13岁；11名女性)进行了研究。fea估计的FL与BMD相关（r = 0.75， p暗场= 0.64，p衰减= 0.82，p暗场= 0.55，p衰减= 0.81,p）结论：在有无骨质疏松/骨质减少的人脊柱标本中，使用临床x射线暗场系统评估的暗场和衰减信号与fea估计的FL显著相关。暗场成像作为一种剂量效率高、易于获取的工具，可以补充现有的骨强度评估方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Musculoskeletal Disorders 医学-风湿病学

CiteScore

3.80

自引率

8.70%

发文量

1017

审稿时长

3-6 weeks

期刊介绍： BMC Musculoskeletal Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of musculoskeletal disorders, as well as related molecular genetics, pathophysiology, and epidemiology. The scope of the Journal covers research into rheumatic diseases where the primary focus relates specifically to a component(s) of the musculoskeletal system.