BMC Endocrine Disorders最新文献

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Insular thyroid carcinoma: epidemiological pattern, factors contributing to recurrence and distant metastasis. 岛状甲状腺癌:流行病学特征、复发及远处转移因素。
IF 2.8 3区 医学
BMC Endocrine Disorders Pub Date : 2025-05-07 DOI: 10.1186/s12902-025-01877-5
Omar Hamdy, Shadi Awny, Mohamed H Sous, Mohamed A Abdelfattah, Ahmed E Eladl, Amr F Elalfy
{"title":"Insular thyroid carcinoma: epidemiological pattern, factors contributing to recurrence and distant metastasis.","authors":"Omar Hamdy, Shadi Awny, Mohamed H Sous, Mohamed A Abdelfattah, Ahmed E Eladl, Amr F Elalfy","doi":"10.1186/s12902-025-01877-5","DOIUrl":"10.1186/s12902-025-01877-5","url":null,"abstract":"<p><strong>Background: </strong>Insular thyroid carcinoma is a rare subtype of thyroid cancer that constitutes an intermediate entity between differentiated (papillary & follicular) and undifferentiated (anaplastic) thyroid cancer.</p><p><strong>Methods: </strong>This is a retrospective study that included all the patients with insular carcinoma of the thyroid gland who underwent surgical treatment in our department from January 2009 to December 2023. The epidemiological, clinical, and oncological data of the included patients were analyzed.</p><p><strong>Results: </strong>A total of 1690 patients with thyroid cancer were screened. Twenty-four patients were included in the final analysis. The median time to recurrence (95% CI) was 24 months while the Restricted Mean Survival Time (RMST) at time point 24 months (95% CI) was 16.95. The median time to distant metastasis is 60 months while RMST at time point 24 months was 17.1. The median time to death was 55 months. There was a statistically significant difference in the RMST at 24 months for overall survival (OS) as regards older age, presence of comorbidity, multifocality, and lack of adjuvant RAI, but not sex. Male sex and lack of adjuvant RAI therapy were statistically significant independent predictors of the time to locoregional recurrence. There was no statistically significant difference in the time to distant metastasis as regards all the variables.</p><p><strong>Conclusions: </strong>From our results, we can conclude that male sex, multifocality, and lack of RAI affect survival in patients with insular thyroid carcinoma. Adequate surgical resection of the thyroid gland and draining lymph nodes in addition to radioactive iodine remains the mainstay of treatment.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"123"},"PeriodicalIF":2.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neonatal graves' disease complicated with cholestatic jaundice: a case report. 新生儿graves病合并胆汁淤积性黄疸1例。
IF 2.8 3区 医学
BMC Endocrine Disorders Pub Date : 2025-05-07 DOI: 10.1186/s12902-025-01938-9
Ya-Ping Tian, Bei Luo, Hui Wang, Hong Jing, Xue-Feng Zhang
{"title":"Neonatal graves' disease complicated with cholestatic jaundice: a case report.","authors":"Ya-Ping Tian, Bei Luo, Hui Wang, Hong Jing, Xue-Feng Zhang","doi":"10.1186/s12902-025-01938-9","DOIUrl":"10.1186/s12902-025-01938-9","url":null,"abstract":"<p><strong>Background: </strong>Neonatal cholestatic jaundice and elevated liver enzymes can result from various etiologies, including anatomical, infectious, endocrine, and metabolic abnormalities. Unlike hypothyroidism, hyperthyroidism is rarely associated with neonatal cholestasis. This study presents a unique case of neonatal Graves' disease complicated by cholestatic jaundice and discusses the challenges in diagnosis, treatment, and management.</p><p><strong>Case presentation: </strong>We report a 30-day-old male infant, born by vaginal delivery at 36.4 weeks gestational age, born weight was 2550 g, to a mother with a history of hypothyroidism during pregnancy, undiagnosed thyroid disease before. The infant developed manifestations of hyperthyroidism, poor weight gain, and cholestatic jaundice shortly after his inception. A variety of tests were used to confirm the diagnosis of neonatal Graves' disease. After 6 weeks of propylthiouracil and hepatoprotective choleretic therapy, thyroid-thyrotropic hormonal metabolism returned to normal, cholestatic jaundice disappeared after 2 months, and liver enzymes returned to normal after 3 months. In addition, the child's weight and length growth returned to the normal range during the follow-up period.</p><p><strong>Conclusions: </strong>Neonatal Graves' disease can be associated with cholestatic jaundice and may have long-term health consequences for the newborn. Early diagnosis and appropriate treatment are crucial for improving the prognosis. This case emphasizes the importance of monitoring pregnant women for thyroid dysfunction and its potential impact on the newborn.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"121"},"PeriodicalIF":2.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Positive impact of mobile educational platforms on blood glucose control in patients with nephrotic syndrome and steroid-induced diabetes mellitus: a randomized controlled study. 移动教育平台对肾病综合征合并类固醇性糖尿病患者血糖控制的积极影响:一项随机对照研究
IF 2.8 3区 医学
BMC Endocrine Disorders Pub Date : 2025-04-27 DOI: 10.1186/s12902-024-01802-2
Zhimin Yang, Zhicheng Tan, Minna Sun, Jing Zhang, Haizhu Hou, Xin Li
{"title":"Positive impact of mobile educational platforms on blood glucose control in patients with nephrotic syndrome and steroid-induced diabetes mellitus: a randomized controlled study.","authors":"Zhimin Yang, Zhicheng Tan, Minna Sun, Jing Zhang, Haizhu Hou, Xin Li","doi":"10.1186/s12902-024-01802-2","DOIUrl":"https://doi.org/10.1186/s12902-024-01802-2","url":null,"abstract":"<p><strong>Objective: </strong>Steroid-induced diabetes mellitus (SDM) is a common complication in patients with nephrotic syndrome (NS) undergoing steroid therapy. Effective blood glucose control is critical for improving outcomes in these patients. This study evaluates the impact of mobile educational platforms on blood glucose control and patient adherence in patients with NS combined with SDM.</p><p><strong>Methods: </strong>A randomised controlled study was conducted involving 56 patients with NS and SDM at Shanxi People's Hospital between April 2019 and December 2020. Participants were recruited using convenient sampling and were randomly assigned to either the intervention group (n = 28) or the control group (n = 28). The control group received routine health management, whereas the experimental group was provided with health management via a mobile educational platform. Blood glucose levels (fasting glucose and postprandial blood glucose), self-management efficacy and patient adherence to treatment were assessed over a 6-month period.</p><p><strong>Results: </strong>The 56 participants included in the study had a mean age of 69.0 ± 10.5 years and an average diabetes duration of 7.2 ± 3.5 years. At the end of 6 months, the intervention group showed significant reductions in fasting blood glucose and postprandial blood glucose levels (P < 0.001). Self-management efficacy, assessed using the Diabetes Self-Efficacy Scale, improved significantly post-intervention (4.42 ± 0.53 vs. 4.15 ± 0.56, P = 0.020). Additionally, patient adherence to treatment improved by 25% in the intervention group compared with the control group.</p><p><strong>Conclusion: </strong>The use of mobile educational platforms significantly resulted in better glycemic control and treatment adherence in the patients with NS and SDM compared to the control group. These findings suggest that integrating mobile health technologies into routine care can enhance disease management and optimise outcomes.</p><p><strong>Trial registration: </strong>The study was retrospectively registered \"ISRCTN23135945\" on 05/11/2024.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"118"},"PeriodicalIF":2.8,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The diagnostic role of FNA based on clinicopathological features in thyroid malignancy. 基于临床病理特征的FNA在甲状腺恶性肿瘤中的诊断作用。
IF 2.8 3区 医学
BMC Endocrine Disorders Pub Date : 2025-04-27 DOI: 10.1186/s12902-025-01945-w
Mohammad Mehdi Fallahi, Sepehr Koulaian, Parviz Mardani, Seyed Ali Malekhosseini, Reza Shahriarirad
{"title":"The diagnostic role of FNA based on clinicopathological features in thyroid malignancy.","authors":"Mohammad Mehdi Fallahi, Sepehr Koulaian, Parviz Mardani, Seyed Ali Malekhosseini, Reza Shahriarirad","doi":"10.1186/s12902-025-01945-w","DOIUrl":"https://doi.org/10.1186/s12902-025-01945-w","url":null,"abstract":"<p><strong>Background: </strong>Thyroid nodules are mostly benign lesions within the thyroid, with a small percentage being malignant. The decision for surgery is mainly based on the fine needle aspiration (FNA) cytology report, which is categorized into six categories from non-diagnostic to malignant. The accuracy of FNA is of utmost importance to minimize the complications due to misdiagnosis.</p><p><strong>Methods: </strong>In a retrospective study, we analyzed 310 patients who underwent thyroidectomy due to suspicious thyroid nodules with both FNA and histopathological results. We reviewed patient files, extracting demographic data, FNA results, and final histopathology reports and grouped them based on the size of the nodules. Sensitivity, specificity, and predictive values were calculated.</p><p><strong>Results: </strong>The average age of the patients was 42.9 ± 13.2 years, and the average size of the largest nodule diameter was 2.1 ± 1.89 cm. Histopathological evaluation of specimens obtained during surgery showed that 184 (59.4%) samples were malignant and 126 (40.6%) were non-malignant. The overall specificity was 96.8%, and the sensitivity was 89.6%, and the accuracy of FNA in diagnosing malignancy was 92.2%. Logistic regression analysis revealed that Bethesda classification (OR: 2.34; 95%CI: 1.73-3.16; P < 0.001), and also tumor size (OR: 2.02; 95%CI: 1.32-3.10; P = 0.001) exhibited a significant direct correlation with the capability of FNA in accurately diagnosing malignancy. The highest FNA accuracy of malignancy detection was among nodules above 3 cm (97.1%) while in nodules smaller than 1 cm the accuracy was 73.2%.</p><p><strong>Conclusion: </strong>FNA is a suitable diagnostic tool for detecting malignant nodules, while diagnostic capability varies with approaches to indeterminate FNA results. False positive and negative rates are crucial, with challenges in diagnosing malignancy in the context of multinodular goiter cases and smaller nodules.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"119"},"PeriodicalIF":2.8,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neutrophil-lymphocyte ratio (NLR); an accurate inflammatory marker to predict diabetic foot ulcer amputation: a matched case-control study. 中性粒细胞-淋巴细胞比值;预测糖尿病足溃疡截肢的准确炎症标志物:一项匹配的病例对照研究。
IF 2.8 3区 医学
BMC Endocrine Disorders Pub Date : 2025-04-27 DOI: 10.1186/s12902-025-01941-0
Faeze Afshar, Morteza Daraie, Fatemeh Mohammadi, Kiana Seifouri, Samira Amin Afshari, Soheil Heidari Some'eh, Amirhossein Yadegar, Parnian Naghavi, Alireza Esteghamati, Soghra Rabizadeh, Mahsa Abbaszadeh, Manouchehr Nakhjavani, Sahar Karimpour Reyhan
{"title":"Neutrophil-lymphocyte ratio (NLR); an accurate inflammatory marker to predict diabetic foot ulcer amputation: a matched case-control study.","authors":"Faeze Afshar, Morteza Daraie, Fatemeh Mohammadi, Kiana Seifouri, Samira Amin Afshari, Soheil Heidari Some'eh, Amirhossein Yadegar, Parnian Naghavi, Alireza Esteghamati, Soghra Rabizadeh, Mahsa Abbaszadeh, Manouchehr Nakhjavani, Sahar Karimpour Reyhan","doi":"10.1186/s12902-025-01941-0","DOIUrl":"https://doi.org/10.1186/s12902-025-01941-0","url":null,"abstract":"<p><strong>Background: </strong>Diabetic foot ulcer (DFU) is a well-known complication of diabetes. The main therapeutic options for treating DFU include surgical debridement. However, conditions such as sensory loss and insufficient blood supply can lead to lower extremity amputations. Inflammatory biomarkers, including the neutrophil‒lymphocyte ratio (NLR) and platelet‒lymphocyte ratio (PLR), have shown promise in predicting the development of diabetes complications.</p><p><strong>Methods: </strong>This study included 126 individuals with known DFUs who underwent amputation or debridement surgery during hospitalization between January 2017 and December 2022. The participants were divided into two groups, each containing 63 patients, based on the treatment they received. Analyses were conducted via univariate and multivariate regression models. The linearity of the relationship between each inflammatory index and the risk of amputation was further examined via restricted cubic spline (RCS) curves with four knots.</p><p><strong>Results: </strong>Categorical regression analysis showed an elevated risk of amputation in patients with an NLR greater than 6.08, with an OR of 13.090 (95% CI: 5.143-33.320, P < 0.001), compared with those with an NLR less than 6.08. Additionally, patients with a PLR greater than 210 demonstrated a similarly elevated risk of amputation with an OR of 2.31 (95% CI: 1.066‒4.669, P = 0.033); however, those with lymphocyte‒white blood cell ratio (LWR) levels of greater than 0.1265 exhibited reduced likelihood of having amputation (OR: 0.092 (95% CI: 0.038‒0.226, P < 0.001)).</p><p><strong>Conclusions: </strong>This study supports that NLR, PLR and LWR may have value as a predictive marker for amputation in patients with DFUs.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"120"},"PeriodicalIF":2.8,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new perspective of blood routine test for the prediction and diagnosis of hyperglycemia. 血常规检查预测和诊断高血糖的新视角。
IF 2.8 3区 医学
BMC Endocrine Disorders Pub Date : 2025-04-25 DOI: 10.1186/s12902-025-01940-1
Wei Wang, Yanjun Zhu, Guangchao Zhao, Xiaojun Kong, Cai Chen, Binbin Chen
{"title":"A new perspective of blood routine test for the prediction and diagnosis of hyperglycemia.","authors":"Wei Wang, Yanjun Zhu, Guangchao Zhao, Xiaojun Kong, Cai Chen, Binbin Chen","doi":"10.1186/s12902-025-01940-1","DOIUrl":"https://doi.org/10.1186/s12902-025-01940-1","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background and aims: &lt;/strong&gt;The presence of hyperglycemia induces alterations in the blood cell microenvironment. However, further investigations are warranted to comprehend the regulation of physiological parameter changes within the hyperglycemic cohort and validate their correlation. This study aims to investigate the correlation between hyperglycemia and peripheral blood physiological parameters, providing valuable insights for the screening and treatment of hyperglycemia.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective study was conducted to analyze the demographic characteristics and blood routine test (blood RT) results of both the normal population and individuals with hyperglycemia. The distribution of abnormal blood RT results was compared between the hyperglycemic groups and the normal group. Univariate and multivariate logistic regression analyses were employed to investigate the correlation between blood RT results and levels of hyperglycemia. In addition, the stored red blood cells (RBCs) were placed in high glucose concentration and low glucose concentration environment, and the changes of physiological parameters of RBCs were observed after 35 days of storage.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The study included a total of 413 participants, with 202 individuals representing the normal population. Among these, there were 95 males (47.03%) and 107 females (52.97%). The hyperglycemia group consisted of individuals with impaired glucose tolerance (IGT) and diabetes mellitus (DM). Out of the total sample, 61 participants with IGT, consisting of 45 males (73.77%) and 16 females (26.23%). Additionally, there were 150 participants with DM, including 107 males (71.33%) and 43 females (28.67%). The prevalence of hyperglycemia showed a significant increase among males aged over 45 years (p &lt; 0.05). The levels of white blood cell count (WBC), red blood cell count (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC) in the hyperglycemia group were significantly higher than those in the normal group (p &lt; 0.05). The distribution of abnormal blood RT results revealed that the DM group had the highest proportion of abnormal WBC, while the IGT group exhibited the highest proportions of abnormal RBC, HGB, and HCT (p &lt; 0.05). Univariate logistic regression analysis showed that WBC (odds ratio [OR], 1.422; 95% CI, 1.249-1.631), RBC (OR, 2.163; 95% CI, 1.449-3.270), HGB (OR, 1.033; 95% CI, 1.020-1.047), HCT (OR, 4.549; 95% CI, 0.569-8.591), MCH (OR, 1.175; 95% CI, 1.057-1.319), MCHC (OR, 1.071; 95% CI, 1.047-1.098) were the predictor indices for hyperglycemia (p &lt; 0.05). Multivariate logistic regression analysis showed that WBC (OR, 1.434; 95% CI, 1.193-1.742) and MCHC (OR, 4.448; 95% CI, 0.084-237.9) were predictor indices for hyperglycemia (p &lt; 0.05). The results of in vitro experiments demonstrated that the high glucose concentration significantly decreased MCV, while c","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"115"},"PeriodicalIF":2.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction of cardiac autonomic dysfunction using heart rate response to deep breathing test among type 2 diabetes mellitus. 利用心率对深呼吸试验的反应预测2型糖尿病患者心脏自主神经功能障碍。
IF 2.8 3区 医学
BMC Endocrine Disorders Pub Date : 2025-04-25 DOI: 10.1186/s12902-025-01939-8
Sohini Raje, G Arun Maiya, Padmakumar R, Mukund A Prabhu, Krishnananda Nayak, K N Shivashankara, B A Shastry, Megha Nataraj, Shreemathi S Mayya
{"title":"Prediction of cardiac autonomic dysfunction using heart rate response to deep breathing test among type 2 diabetes mellitus.","authors":"Sohini Raje, G Arun Maiya, Padmakumar R, Mukund A Prabhu, Krishnananda Nayak, K N Shivashankara, B A Shastry, Megha Nataraj, Shreemathi S Mayya","doi":"10.1186/s12902-025-01939-8","DOIUrl":"https://doi.org/10.1186/s12902-025-01939-8","url":null,"abstract":"<p><strong>Background: </strong>Cardiac autonomic neuropathy (CAN) is an underdiagnosed complication of type 2 diabetes mellitus (T2DM) and a predictor of mortality and cardiovascular morbidity. Hence, CAN screening is essential. The objective of the study was to examine whether cardiac autonomic dysfunction can be predicted using the heart rate response to deep breathing test of cardiac autonomic reflex tests (CARTs) among type 2 diabetes mellitus.</p><p><strong>Methods: </strong>The study was a cross-sectional study of T2DM individuals between 40 and 65 years. Each participant underwent a heart rate (HR) response to deep breathing test (CARTs) as per standard guidelines. ANOVA F-test was used to check the difference between the CAN severity and the heart rate response to deep breathing parameters. A post-hoc (Tukey's) test was used to check which groups showed the difference.</p><p><strong>Results: </strong>Eighty-four participants were screened, of which forty-one were included in the present study. The mean age of the participants was 58.8 ± 4.0 years. The Fisher's test showed a statistically significant difference between groups for the average deep breathing difference (F(3,27) = 16.09, p < 0.001) and the respiratory sinus arrhythmia index (F(3,27) = 7.35, p < 0.001).</p><p><strong>Conclusion: </strong>HR response to deep breathing can be used as a preliminary tool to screen CAN in T2DM to differentiate between normal and the other stages of CAN, which can then be followed by the gold standard tests. Further studies are required to establish HR response to deep breathing as a singular tool using regression analysis.</p><p><strong>Clinical trials registration: </strong>The study was registered prospectively in the Clinical Trials Registry- India (CTRI/2023/11/060077) on 21st November 2023.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"117"},"PeriodicalIF":2.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of intraoperative intact PTH monitoring on reoperation rates and surgical success in primary hyperparathyroidism. 术中完整甲状旁腺素监测对原发性甲状旁腺功能亢进患者再手术率及手术成功率的影响。
IF 2.8 3区 医学
BMC Endocrine Disorders Pub Date : 2025-04-25 DOI: 10.1186/s12902-025-01942-z
Farshad Noori, Erdal Güceoğlu, Yunushan Furkan Aydoğdu, Çağrı Büyükkasap, Ramazan Kozan, Kürşat Dikmen, Özlem Gülbahar, Murat Akın, Ömer Şakrak
{"title":"Impact of intraoperative intact PTH monitoring on reoperation rates and surgical success in primary hyperparathyroidism.","authors":"Farshad Noori, Erdal Güceoğlu, Yunushan Furkan Aydoğdu, Çağrı Büyükkasap, Ramazan Kozan, Kürşat Dikmen, Özlem Gülbahar, Murat Akın, Ömer Şakrak","doi":"10.1186/s12902-025-01942-z","DOIUrl":"https://doi.org/10.1186/s12902-025-01942-z","url":null,"abstract":"<p><strong>Background: </strong>Primary hyperparathyroidism (PHPT) is caused by excessive parathormone secretion from one or more parathyroid glands. The primary treatment for PHPT is surgery. Due to anatomical variations in the parathyroid glands, preoperative localization, surgical approaches, and success rates can vary. With the development of advanced imaging techniques and the introduction of intraoperative intact PTH (i-PTH) measurement, traditional extended surgical approaches have increasingly been replaced by focused surgeries.</p><p><strong>Objective: </strong>Intraoperative i-PTH measurement has been applied by different surgeons using various criteria. This study aims to evaluate the effectiveness of intraoperative i-PTH measurement in improving surgical success, particularly in cases with inconclusive preoperative imaging results.</p><p><strong>Methods: </strong>Between January 2010 and September 2020, 203 adult patients who underwent surgery for PHPT in our clinic were included in the study. Patients were categorized into two groups: Group A (with intraoperative i-PTH measurement) and Group B (without i-PTH measurement). Persistent hyperparathyroidism was defined as elevated calcium levels occurring shortly after surgery, whereas recurrence was defined as calcium elevation after the 6th postoperative month. The absence of recurrence or persistent hypercalcemia was considered an indicator of surgical success.</p><p><strong>Results: </strong>The mean age of the patients was 54.6 ± 12.7 years. Of the 203 patients, 40 (19.7%) were male and 163 (80.3%) were female. No correlation was found between recurrence or persistence and patient age. The overall success rate was 93.6%. Surgical success was achieved in 97.8% of patients in Group A and 90% in Group B, indicating a statistically significant difference between the groups (p = 0.023).</p><p><strong>Conclusion: </strong>Intraoperative i-PTH measurement significantly increases the success rate of PHPT surgery, reducing the incidence of recurrent or persistent cases and the need for secondary operations. Consequently, it helps prevent complications associated with reoperations. These findings highlight the pivotal role of intraoperative i-PTH monitoring in optimizing surgical outcomes, especially in complex PHPT cases.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"116"},"PeriodicalIF":2.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mediating effect of TyG index on the association between glucose-lipid metabolism-related dietary pattern and T2DM: a propensity score-matched analysis. TyG指数在糖脂代谢相关饮食模式与T2DM之间的中介作用:倾向评分匹配分析
IF 2.8 3区 医学
BMC Endocrine Disorders Pub Date : 2025-04-24 DOI: 10.1186/s12902-025-01892-6
ShuShu Li, Rong Xia, Xing Gong, Chao Wang, Hechun Liu, Huibin Dong, Zhangyao Su, Yucheng Liang, Shoulin Wang, Tao Yang
{"title":"Mediating effect of TyG index on the association between glucose-lipid metabolism-related dietary pattern and T2DM: a propensity score-matched analysis.","authors":"ShuShu Li, Rong Xia, Xing Gong, Chao Wang, Hechun Liu, Huibin Dong, Zhangyao Su, Yucheng Liang, Shoulin Wang, Tao Yang","doi":"10.1186/s12902-025-01892-6","DOIUrl":"https://doi.org/10.1186/s12902-025-01892-6","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the association of dietary patterns (DPs) with risk of T2DM, emphasizing the intermediary role of HOMA or TyG indices among a Chinese adult population.</p><p><strong>Research design and methods: </strong>Directed acyclic graphs combined with propensity score matching were used to minimize confounding, resulting in 1330 subjects for final analysis. Principal component analysis and reduced rank regression, applied to eleven food groups. Multivariable logistic regression and restricted cubic spline regression models were used to assess associations between there DPs with prevalent T2DM, as well as insulin resistance and β-cell function (HOMA-TyG). Mediation analyses were conducted to evaluate whether the HOMA-TyG index mediated the relationship between DPs and T2DM.</p><p><strong>Results: </strong>The DP1, characterized by high intakes of poultry, meat, and preserved foods, was associated with elevated body mass index, triglycerides, and hemoglobin A1c. Both PCA-DP1(OR<sub>Q4VsQ1</sub> = 2.15, 95% CI: 1.53-3.03) and RRR-DP1 (OR<sub>Q4VsQ1</sub> = 1.69, 95% CI: 1.82-3.58) were significantly positively correlated with T2DM. RRR-DP1 additionally demonstrated a dose-dependent relationship with HOMA-insulin resistance and TyG. Furthermore, the TyG index mediated approximately 19.51% of the relationship between RRR-DP1 and T2DM.</p><p><strong>Conclusions: </strong>These findings indicate that glucose-lipid metabolism-related dietary pattern, notably high in animal fat, exacerbates insulin resistance and heightens T2DM risk. Tailoring dietary interventions to modify this pattern may be an effective strategy for preventing and managing T2DM.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"114"},"PeriodicalIF":2.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between glucose time-in-range and the severity of metabolic dysfunction-associated steatotic liver disease in Chinese adults with type 2 diabetes mellitus. 中国成人2型糖尿病患者血糖时间范围与代谢功能障碍相关脂肪变性肝病严重程度的关系
IF 2.8 3区 医学
BMC Endocrine Disorders Pub Date : 2025-04-23 DOI: 10.1186/s12902-025-01937-w
Chun-Hua Wang, Xuan-Yao Ji, Nian Ji, Qing-Feng Yan, Hong-Qing Xu, Xue-Qin Wang, Xiang-Fan Chen, Chun-Feng Lu
{"title":"Association between glucose time-in-range and the severity of metabolic dysfunction-associated steatotic liver disease in Chinese adults with type 2 diabetes mellitus.","authors":"Chun-Hua Wang, Xuan-Yao Ji, Nian Ji, Qing-Feng Yan, Hong-Qing Xu, Xue-Qin Wang, Xiang-Fan Chen, Chun-Feng Lu","doi":"10.1186/s12902-025-01937-w","DOIUrl":"10.1186/s12902-025-01937-w","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the correlation between glucose time-in-range (TIR) and hepatic steatosis severity or liver fibrosis risk in Chinese adults with type 2 diabetes mellitus (T2DM) comorbid with metabolic dysfunction-associated steatotic liver disease (MASLD).</p><p><strong>Methods: </strong>Participants with T2DM were evaluated for hepatic steatosis and fibrosis using vibration-controlled transient elastography. TIR was calculated based on data from a retrospective continuous glucose monitoring system.</p><p><strong>Results: </strong>A total of 184 T2DM patients with MASLD were enrolled. The controlled attenuation parameter (CAP) and liver stiffness measurement (LSM) decreased with increasing TIR (p < 0.05). Spearman correlation showed negative correlations between CAP, LSM, and TIR (r = -0.824 and - 0.842, p < 0.05) and positive correlations with basal insulin resistance (HOMA-IR) (r = 0.205 and 0.208, p < 0.01). Multiple linear regression revealed TIR and HOMA-IR independently correlated with CAP (std. regression coefficients = -0.695 and 0.103, p < 0.05) and LSM (std. regression coefficients = -0.735 and 0.083, p < 0.05), wit0.34 h TIR having a stronger impact. Binary logistic regression showed TIR Groups 3 (70% ≥ TIR < 85%) and 4 (TIR ≥ 85%) were protective for MASLD (OR = 0.26 and 0.11, 95% CI 0.10-0.66 and 0.04-0.29, P = 0.005 and < 0.001) and liver fibrosis (OR = 0.29 and 0.13, 95% CI 0.12-0.74 and 0.05-0.36, P = 0.010 and < 0.001) compared to TIR Group 1 (lowest quartile).</p><p><strong>Conclusion: </strong>In T2DM patients with coexisting MASLD, a significant and independent association existed between TIR and the severity of hepatic steatosis.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"113"},"PeriodicalIF":2.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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