Relationship between level of serum VIT D and insulin resistance in patients with MAFLD.

Background: Non-alcoholic fatty liver disease has been recognized as the most common metabolic liver disease in Western countries, and its prevalence is increasing all over the world. Metabolic syndrome and diabetes mellitus (DM) are closely linked to non-alcoholic fatty liver disease. Because of the close relationship between fatty liver and metabolic illnesses, NAFLD has lately been renamed as Metabolic Associated Fatty Liver Disease. HOMA-IR is thought to be the best indicator of the progression of fatty liver to advanced cirrhosis and fibrosis.

Aim: to assess the relation between level of serum VIT D and insulin resistance in patients with MAFLD.

Patients & methods: This cross sectional observational study included 120 subjects (60 control & 60 MAFLD patients), where clinical examination including anthropometric measurements, laboratory tests (CBC, liver and renal function, metabolic profile, serum VIT D, HOMA-IR), ultrasonography and shear wave elastography were performed on all the subjects.

Results: In MAFLD patients, serum vitamin D levels were statistically significant lower (55%) than in the non-MAFLD group (15%), and they also significantly decreased as steatosis and fibrosis grades increased (P < 0.001). In addition, there is an inverse correlation between serum vitamin D levels and IR in MAFLD patients, but it is not statistically significant.

Conclusion: Vitamin D supplementation may be helpful in the treatment of MAFLD since people with the condition have lower serum vitamin D levels than those without it, and these levels drastically decreased with increasing grades of fatty liver.