Biophysical reviews最新文献_第9页

Calcium and magnesium phosphates bone cements for biovisualization and theranostic applications. 磷酸钙镁骨水泥的生物可视化和治疗应用。

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Biophysical reviews Pub Date : 2025-10-23 eCollection Date: 2025-10-01 DOI: 10.1007/s12551-025-01369-9

Margarita A Goldberg, Polina A Krokhicheva, Margarita A Sadovnikova, Marat R Gafurov, Vladimir S Komlev

{"title":"Calcium and magnesium phosphates bone cements for biovisualization and theranostic applications.","authors":"Margarita A Goldberg, Polina A Krokhicheva, Margarita A Sadovnikova, Marat R Gafurov, Vladimir S Komlev","doi":"10.1007/s12551-025-01369-9","DOIUrl":"10.1007/s12551-025-01369-9","url":null,"abstract":"The extensive bone defects caused by trauma or different diseases should be filled with materials that stimulate the formation of new bone tissue. The main advantages of inorganic calcium and magnesium phosphate cement materials, including injectable bone cements, are their ability to fill complex bone defects, provide appropriate mechanical properties and resorption kinetics with further new bone formation, and also provide theranostic special functional properties. These bone cements are also used in minimally invasive surgical techniques, such as vertebroplasty and kyphoplasty, as well as in oncology and dentistry. Monitoring dentistry procedures and assessing recovery during new bone formation requires observation using non-invasive methods for biovisualisation. The development of cement materials with theranostic effects could suggest a novel opportunity for treatment strategies for primary and metastatic bone tumors. This review illustrates the state of the art in modern bioimaging of bone cements based on calcium and magnesium phosphates, which refers to the use of several imaging techniques and also provides therapeutic effects, including cancer cleaning, antibacterial properties, and osteogenic differentiation.","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"17 5","pages":"1319-1332"},"PeriodicalIF":5.0,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12847614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NMR metabolomics in genetically engineered mouse models. 核磁共振代谢组学在基因工程小鼠模型。

IF 5

Biophysical reviews Pub Date : 2025-10-20 eCollection Date: 2025-10-01 DOI: 10.1007/s12551-025-01378-8

Kamil N Aysin, Alexander Yu Rudenko, Sofia S Mariasina, Vladimir I Polshakov

{"title":"NMR metabolomics in genetically engineered mouse models.","authors":"Kamil N Aysin, Alexander Yu Rudenko, Sofia S Mariasina, Vladimir I Polshakov","doi":"10.1007/s12551-025-01378-8","DOIUrl":"10.1007/s12551-025-01378-8","url":null,"abstract":"Metabolomics has become a central approach for elucidating metabolic alterations associated with disease pathogenesis, therapeutic responses, and genetic perturbations. Among the dominant analytical platforms, nuclear magnetic resonance (NMR) spectroscopy is particularly valued for its reproducibility, quantitative accuracy, and minimal sample preparation. These strengths make NMR especially powerful for studies employing genetically engineered mouse models (GEMMs), which remain indispensable for investigating the molecular basis of human disease. This review examines key methodological aspects of NMR metabolomics, including data analysis platforms, the choice of pulse sequences, and strategies to enhance sensitivity and resolution. We summarize applications across major disease areas such as cancer, diabetes, and neurological disorders, with particular emphasis on stable isotope-resolved metabolomics, a powerful approach for dynamic pathway analysis and metabolic flux modeling in intact systems. We also highlight how NMR studies of knockout models have uncovered subtle metabolic perturbations and clarified gene-metabolism relationships. A recurring theme is the evaluation of reproducibility across GEMMs and the challenge of translating metabolic findings from mouse models to human pathophysiology. Finally, we outline current limitations and future directions for advancing the role of NMR metabolomics in preclinical and biomedical research.","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"17 5","pages":"1373-1400"},"PeriodicalIF":5.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12847615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cholesterol in model membranes. 模型膜中的胆固醇。

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Biophysical reviews Pub Date : 2025-10-18 eCollection Date: 2025-12-01 DOI: 10.1007/s12551-025-01377-9

James H Davis

引用次数: 0

Biophysics in Great Britain and Ireland. 英国和爱尔兰的生物物理学。

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Biophysical reviews Pub Date : 2025-10-07 eCollection Date: 2025-08-01 DOI: 10.1007/s12551-025-01367-x

Stephen Harding, Anthony Watts

引用次数: 0

Second harmonic generation for brain imaging: pathology-related studies. 脑成像的二次谐波产生：病理相关研究。

IF 5

Biophysical reviews Pub Date : 2025-09-27 DOI: 10.1007/s12551-025-01370-2

Mikhail Paveliev, Anastasiia Melnikova, Dmitry V Samigullin, Anton A Egorchev, Angelina A Titova, Andrey P Kiyasov, Irina Yu Popova, Vladimir Parpura, Albert V Aganov

{"title":"Second harmonic generation for brain imaging: pathology-related studies.","authors":"Mikhail Paveliev, Anastasiia Melnikova, Dmitry V Samigullin, Anton A Egorchev, Angelina A Titova, Andrey P Kiyasov, Irina Yu Popova, Vladimir Parpura, Albert V Aganov","doi":"10.1007/s12551-025-01370-2","DOIUrl":"10.1007/s12551-025-01370-2","url":null,"abstract":"Microscopy of the brain has been facing problems of contrast and thick tissue imaging. Second harmonic generation (SHG) is a non-linear effect of the light interaction with the imaged material, resulting in photon emission at half the wavelength of the absorbed light. SHG microscopy provides an unprecedented opportunity for imaging collagen and other noncentrosymmetric protein fibrils in unstained thick tissue samples and in the live brain via a regular multiphoton setup. This opens a remarkable methodological window for imaging pathological processes of high importance, including brain trauma, fibrosis, tumorigenesis, and neuroimplant-induced foreign body response. Moreover, SHG is a valuable tool for imaging astrocytes and nerve fiber microtubules. Third harmonic generation enhanced by three-photon resonance with the Soret band of hemoglobin is combined with SHG to resolve the microstructure of blood vessel walls and astrocyte-process endfeet on gliovascular interfaces. Here, we review current state-of-the-art methods in the field of brain imaging applications of SHG, including research on brain and spinal cord injury, glioma, ischemia, Alzheimer's disease, neuroimplantation, and brain meninges. We then address the method development perspective in the broader context of other tissue pathologies. Finally, we account for recent progress in artificial intelligence applications for SHG microscopy data analysis.","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12685055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The neuronal imaging in cardiology: 123I-mIBG in clinical practice. 神经影像学在心脏病学中的应用：123I-mIBG在临床中的应用。

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Biophysical reviews Pub Date : 2025-09-26 eCollection Date: 2025-10-01 DOI: 10.1007/s12551-025-01368-w

L E Samoilenko, S A Ryzhkin, V B Sergienko

引用次数: 0

The COVID-19 pandemic and its consequences on men's reproductive health. COVID-19大流行及其对男性生殖健康的影响。

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Biophysical reviews Pub Date : 2025-09-22 eCollection Date: 2025-10-01 DOI: 10.1007/s12551-025-01364-0

T M Rozhnova, Daria V Starynina, A M Bubnova, Yuriy Yu Vinnik, Alexandra V Moiseeva, Svetlana V Kostyuk, Kseniya S Rozhnova, Vladimir N Nikolenko, Yuriy L Orlov

{"title":"The COVID-19 pandemic and its consequences on men's reproductive health.","authors":"T M Rozhnova, Daria V Starynina, A M Bubnova, Yuriy Yu Vinnik, Alexandra V Moiseeva, Svetlana V Kostyuk, Kseniya S Rozhnova, Vladimir N Nikolenko, Yuriy L Orlov","doi":"10.1007/s12551-025-01364-0","DOIUrl":"10.1007/s12551-025-01364-0","url":null,"abstract":"The COVID-19 pandemic has significantly impacted global health; key questions remain regarding its effects on male reproductive function. Male infertility represents both a biomedical challenge and a societal concern. Our review considers COVID-19's biophysical mechanisms affecting the male reproductive system and focuses on the prognostic implication. Current evidence highlights two primary pathways of SARS-CoV-2 impact: hyperthermia and oxidative stress. The first pathway, as reported, significantly increases sperm aneuploidy and, as a result, has adverse effects on spermatogenesis and causes sperm DNA breaks. The second pathway of coronavirus impact on infertility is oxidative stress. During it, the level of formation of reactive oxygen species (ROS) increases and damages sperm membrane by lipid peroxidation. These mechanisms are interrelated, as fever-induced oxidative stress may alter redox-active metal homeostasis, further exacerbating cellular damage. Understanding these pathogenic processes enables targeted therapeutic development and preventive strategies for COVID-19-related male reproductive dysfunction.","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"17 5","pages":"1643-1650"},"PeriodicalIF":5.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12847545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biophysical perspectives of the spatiotemporal dynamics of plasma coagulation under flow. 流动条件下血浆凝固时空动力学的生物物理视角。

IF 5

Biophysical reviews Pub Date : 2025-09-10 eCollection Date: 2025-10-01 DOI: 10.1007/s12551-025-01365-z

Andrei D Megalinskii, Yury D Nechipurenko, Mikhail A Panteleev, Dmitry Yu Nechipurenko

{"title":"Biophysical perspectives of the spatiotemporal dynamics of plasma coagulation under flow.","authors":"Andrei D Megalinskii, Yury D Nechipurenko, Mikhail A Panteleev, Dmitry Yu Nechipurenko","doi":"10.1007/s12551-025-01365-z","DOIUrl":"10.1007/s12551-025-01365-z","url":null,"abstract":"Gelation of blood plasma is key to normal hemostasis. The regulation of coagulation in blood flow has been studied for several decades, but the key problems in the field remain unresolved. Understanding the major mechanisms governing coagulation under flow conditions is important for the development of new diagnostic tools, therapeutic agents, and novel strategies addressing pathological states associated with both hypo- and hypercoagulation. In this review, we highlight the general features of plasma coagulation under flow conditions, including its spatiotemporal dynamics and threshold dependence on the key parameters. A short overview of in vitro and in silico models and important breakthroughs that became possible with their combination is followed by a brief introduction into the analysis of the balance between convection, diffusion, and reactions using Peclet and Damköhler numbers. We highlight the major unresolved challenges in the field and share an overall perspective of the future directions that might help to clarify the important questions that emerged during the last decade of intensive research.","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"17 5","pages":"1529-1541"},"PeriodicalIF":5.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12847499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Capillary microfluidics aided single-cell manipulation for optical detection of bacterial pathogens. 毛细管微流体辅助单细胞操作用于细菌病原体的光学检测。

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Biophysical reviews Pub Date : 2025-09-05 eCollection Date: 2026-04-01 DOI: 10.1007/s12551-025-01363-1

Sulaxna Pandey, Navya Sethu, Madhusudan B Kulkarni, Renu Vyas

{"title":"Capillary microfluidics aided single-cell manipulation for optical detection of bacterial pathogens.","authors":"Sulaxna Pandey, Navya Sethu, Madhusudan B Kulkarni, Renu Vyas","doi":"10.1007/s12551-025-01363-1","DOIUrl":"10.1007/s12551-025-01363-1","url":null,"abstract":"The detection of bacterial pathogens at the single-cell level is critical for early diagnosis, understanding microbial behavior, and monitoring treatment efficacy. Capillary microfluidics, with its precise fluid control and ability to manipulate single cells, has emerged as a powerful tool in this field. This review explores recent advancements in capillary microfluidics techniques for single-cell manipulation and their integration with optical detection methods to identify bacterial pathogens. Various microfluidic designs, such as capillary-based traps and sieves that enable the isolation and analysis of individual bacterial cells are presented in the review. Additionally, microfluidic-based single-cell detection techniques and optical detection modalities, such as fluorescence microscopy and Raman spectroscopy, that provide highly sensitive and specific pathogen identification are highlighted. The review also addresses the challenges in scaling up these technologies for clinical applications and offers insights into future trends in capillary microfluidics for pathogen detection. Capillary microfluidics-aided single-cell analysis represents a promising frontier in the rapid, accurate, and low-cost detection of bacterial pathogens, with significant implications for public health and disease management.Supplementary information: The online version contains supplementary material available at 10.1007/s12551-025-01363-1.","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"18 2","pages":"459-475"},"PeriodicalIF":5.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13272692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-throughput investigation of macromolecular interactions for drug development using spectral shift technology. 利用光谱移位技术对药物开发中的大分子相互作用进行高通量研究。

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Biophysical reviews Pub Date : 2025-09-03 eCollection Date: 2025-08-01 DOI: 10.1007/s12551-025-01359-x

Charlotte E Hunter, Ehmke Pohl, Stefanie Freitag-Pohl

引用次数: 0