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Cofactor recycling strategies for secondary metabolite production in cell-free protein expression systems. 无细胞蛋白表达系统中次生代谢物产生的辅因子回收策略。
IF 4.9
Biophysical reviews Pub Date : 2024-09-26 eCollection Date: 2024-10-01 DOI: 10.1007/s12551-024-01234-1
Yutong Zou, Constance B Bailey
{"title":"Cofactor recycling strategies for secondary metabolite production in cell-free protein expression systems.","authors":"Yutong Zou, Constance B Bailey","doi":"10.1007/s12551-024-01234-1","DOIUrl":"https://doi.org/10.1007/s12551-024-01234-1","url":null,"abstract":"<p><p>Cell-free protein synthesis (CFPS) has emerged as an attractive platform for biotechnology and synthetic biology due to its numerous advantages to cell-based technologies for specific applications. CFPS can be faster, less sensitive to metabolite toxicity, and amenable to systems that are not easily genetically manipulated. Due to these advantages, a promising application of CFPS is to characterize biosynthetic gene clusters, particularly those harbored within the genomes of microorganisms that generate secondary metabolites, otherwise known as natural products. In the postgenomic era, genome sequencing has revealed an incredible wealth of metabolic diversity. However, far more of these pathways are termed \"cryptic,\" i.e., unable to be produced under standard laboratory conditions than have been characterized. A major barrier to characterizing these cryptic natural products using CFPS is that many of these pathways require utilization of complex cofactors, many of which to date are not recycled efficiently or in an economically viable fashion. In this perspective, we outline strategies to regenerate cofactors relevant to secondary metabolite production in CFPS. This includes adenosine 5'-triphosphate, coenzyme A, redox cofactors (iron-sulfur clusters, nicotinamide adenine dinucleotide phosphate, flavin adenine dinucleotide), all of which play a crucial role in important biosynthetic enzymes. Such advances in cofactor recycling enable continuous production of complex metabolites in CFPS and expand the utility of this emergent platform.</p>","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"16 5","pages":"591-603"},"PeriodicalIF":4.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prebiotic chemistry and protocells during the faint young sun event. 生命前化学和原始细胞在微弱的年轻太阳事件。
IF 4.9
Biophysical reviews Pub Date : 2024-09-26 eCollection Date: 2024-10-01 DOI: 10.1007/s12551-024-01223-4
Navaniswaran Tharumen, Mahendran Sithamparam, Tony Z Jia, Kuhan Chandru
{"title":"Prebiotic chemistry and protocells during the faint young sun event.","authors":"Navaniswaran Tharumen, Mahendran Sithamparam, Tony Z Jia, Kuhan Chandru","doi":"10.1007/s12551-024-01223-4","DOIUrl":"https://doi.org/10.1007/s12551-024-01223-4","url":null,"abstract":"<p><p>The sun generates light and heat for life on Earth to flourish. However, during the late Hadean-early Archean epoch on Earth, the \"faint young sun\" (FYS) was less luminous, influencing prebiotic chemistry and, by extension, the origins of life (OoL). However, higher levels of ultraviolet (UV) radiation from the FYS, especially UV-C, due to the lack of an ozone layer, would likely have impacted the assembly, stability, persistence, and functions of prebiotic cellular precursors, i.e., protocells. Consequently, it is essential to study how such UV-C radiation would have affected the synthesis and stability of prebiotically relevant molecules and protocells to better understand the plausibility of the OoL during the FYS period. In this letter, we introduce unanswered questions surrounding the structure and stability of protocells under UV-C radiation. Such a perspective may be vital to exoplanetary systems orbiting other stars, enhancing our understanding of life's potential beyond our solar system.</p>","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"16 5","pages":"651-654"},"PeriodicalIF":4.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overview of the super-resolution and advanced microscopy imaging session at the 21st IUPAB and the 62nd Biophysics Society of Japan joint congress. 第21届IUPAB和第62届日本生物物理学会联合大会超分辨率和高级显微成像会议概述。
IF 4.9
Biophysical reviews Pub Date : 2024-09-24 eCollection Date: 2024-10-01 DOI: 10.1007/s12551-024-01228-z
Takanobu A Katoh, Elizabeth Hinde
{"title":"Overview of the super-resolution and advanced microscopy imaging session at the 21st IUPAB and the 62nd Biophysics Society of Japan joint congress.","authors":"Takanobu A Katoh, Elizabeth Hinde","doi":"10.1007/s12551-024-01228-z","DOIUrl":"https://doi.org/10.1007/s12551-024-01228-z","url":null,"abstract":"<p><p>Recent advancements in microscopic techniques have significantly progressed, with improvements in fundamental parameters such as resolution, as well as the emergence of novel imaging techniques for measuring cellular information. In this session, six invited speakers introduced recent advancements in super-resolution and advanced microscopy imaging, covering both the development of novel microscopy techniques and their biological applications.</p>","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"16 5","pages":"547-550"},"PeriodicalIF":4.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commentary: Biophysics and Physicobiology, the official international journal of the Biophysical Society of Japan. 评论：生物物理学和物理生物学，日本生物物理学会的官方国际期刊。
IF 4.9
Biophysical reviews Pub Date : 2024-09-20 eCollection Date: 2024-10-01 DOI: 10.1007/s12551-024-01225-2
Haruki Nakamura
{"title":"Commentary: <i>Biophysics and Physicobiology</i>, the official international journal of the Biophysical Society of Japan.","authors":"Haruki Nakamura","doi":"10.1007/s12551-024-01225-2","DOIUrl":"https://doi.org/10.1007/s12551-024-01225-2","url":null,"abstract":"<p><p>This Commentary outlines recent advances of <i>Biophysics and Physicobiology</i> (<i>BPPB</i>), the official international peer-reviewed journal published by the Biophysical Society of Japan (BSJ), a member of the International Union of Pure and Applied Biophysics (IUPAB). In June 2024, BSJ hosted the 21st IUPAB Congress in Kyoto, which was attended by over 1900 participants from 52 countries and regions. The role of <i>BPPB</i> as an open-access (OA) journal within the framework of the future Japanese governmental OA policy is also discussed.</p>","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"16 5","pages":"505-507"},"PeriodicalIF":4.9,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the dynamics of allostery through multi-dimensional crystallography. 通过多维晶体学探索变构动力学。
IF 4.9
Biophysical reviews Pub Date : 2024-09-19 eCollection Date: 2024-10-01 DOI: 10.1007/s12551-024-01224-3
C E Hatton, P Mehrabi
{"title":"Exploring the dynamics of allostery through multi-dimensional crystallography.","authors":"C E Hatton, P Mehrabi","doi":"10.1007/s12551-024-01224-3","DOIUrl":"https://doi.org/10.1007/s12551-024-01224-3","url":null,"abstract":"<p><p>By delving into the applications, methodologies, and case studies of multi-dimensional crystallography, whereby time and temperature are varied in the context of allostery, this review aims to elucidate the intricate interplay between structure, dynamics, and function in allosteric proteins. As the field of structural biology continues to advance, integrating multi-dimensional approaches promises to unlock new frontiers in our quest to decipher the molecular mechanisms governing life.</p>","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"16 5","pages":"563-570"},"PeriodicalIF":4.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Data Science for Integrated Dynamic Structural Biology-the 21st IUPAB Congress session summary commentary. 集成动态结构生物学的数据科学-第21届IUPAB大会总结评论。
IF 4.9
Biophysical reviews Pub Date : 2024-09-02 eCollection Date: 2024-10-01 DOI: 10.1007/s12551-024-01222-5
Florence Tama, Jianhan Chen
{"title":"Data Science for Integrated Dynamic Structural Biology-the 21st IUPAB Congress session summary commentary.","authors":"Florence Tama, Jianhan Chen","doi":"10.1007/s12551-024-01222-5","DOIUrl":"10.1007/s12551-024-01222-5","url":null,"abstract":"<p><p>The session \"Data Science for Integrated Dynamic Structural Biology\" was a notable success at the joint congress of the 21st IUPAB and the 62nd BSJ (Biophysics Society of Japan). This session included four invited talks and one contributed talk, which together delved into recent advancements in computational methods integrating physics, experimental data, and bioinformatics to study the structure and dynamic properties of molecular assemblies and their interactions.</p>","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"16 5","pages":"529-531"},"PeriodicalIF":4.9,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photopolymerizable robust lipids towards reliability and their applications. 面向可靠性的光聚合坚固脂质及其应用。
IF 4.9
Biophysical reviews Pub Date : 2024-08-31 eCollection Date: 2024-12-01 DOI: 10.1007/s12551-024-01221-6
Ariana Bujan, Silvia Del Valle Alonso, Nadia S Chiaramoni
{"title":"Photopolymerizable robust lipids towards reliability and their applications.","authors":"Ariana Bujan, Silvia Del Valle Alonso, Nadia S Chiaramoni","doi":"10.1007/s12551-024-01221-6","DOIUrl":"10.1007/s12551-024-01221-6","url":null,"abstract":"<p><p>Synthetic lipids have been studied as components in membrane models and drug delivery systems. Polymerizable phospholipids, especially photosensitive ones, can form new bilayer bonds when UV light irradiates. These phospholipids have been known since the 1980s, but in the last few years, new applications have been highlighted. Its use in drug delivery systems is interesting since the photopolymerization reaction produces highly stable vesicles. Additionally, the rearrangement of the acyl chains during the photopolymerization process can be applied in the generation of pores, resulting in systems that serve for drug-controlled release. In this article, our goal was to envision earlier photopolymers' publications towards the implications of these versatile phospholipids that led to proposed systems for drug delivery and controlled release of drugs at specific sites. This review offers a broad background towards a simple, reliable, and robust platform to make its application available.</p>","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"16 6","pages":"773-782"},"PeriodicalIF":4.9,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biophysical Reviews' "Meet the Editors Series"-a profile of Anthony Watts. 生物物理评论》的 "编辑见面系列"--Anthony Watts 的简介。
IF 4.9
Biophysical reviews Pub Date : 2024-08-31 eCollection Date: 2024-08-01 DOI: 10.1007/s12551-024-01214-5
Anthony Watts
{"title":"<i>Biophysical Reviews</i>' \"Meet the Editors Series\"-a profile of Anthony Watts.","authors":"Anthony Watts","doi":"10.1007/s12551-024-01214-5","DOIUrl":"10.1007/s12551-024-01214-5","url":null,"abstract":"<p><p>Soon after Biophysical Reviews was established as a Journal with Springer Verlag in 2009, I was asked to join the editorial board. I have juggled various editorial board responsibilities for several Journals over more than three decades, viewing this as a service to the ever-growing biophysics community. How I got to be involved with biophysics is a long story, but here are a few relevant explanations, with much omitted. Anthony Watts.</p>","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"16 4","pages":"387-396"},"PeriodicalIF":4.9,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell motility, cytoskeleton, and motor proteins-21st IUPAB Congress session commentary. 细胞运动，细胞骨架和运动蛋白-第21届IUPAB大会评论。
IF 4.9
Biophysical reviews Pub Date : 2024-08-27 eCollection Date: 2024-10-01 DOI: 10.1007/s12551-024-01218-1
Ikuko Fujiwara, Sarah Köster
{"title":"Cell motility, cytoskeleton, and motor proteins-21st IUPAB Congress session commentary.","authors":"Ikuko Fujiwara, Sarah Köster","doi":"10.1007/s12551-024-01218-1","DOIUrl":"https://doi.org/10.1007/s12551-024-01218-1","url":null,"abstract":"<p><p>The cytoskeleton is the major mechanical unit of the cell and is essential for cellular processes such as motility, division, and contraction. It consists of three types of biopolymers-actin filaments, microtubules, and intermediate filaments-along with passive cross-linkers and active motor proteins. This composite biological material determines the enormous viscoelastic adaptability of cells to varying mechanical demands. In the session entitled \"Cell Motility, Cytoskeleton, and Motor Proteins\" at the IUPAB 2024 Congress in Kyoto, Japan, we elucidated specific examples of cell mechanics and dynamics from a physical point of view, including different length scales from molecular to cellular, as well as in vitro reconstituted systems and cellular systems.</p>","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"16 5","pages":"521-523"},"PeriodicalIF":4.9,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biophysical Reviews: the official journal of the International Union for Pure and Applied Biophysics. 生物物理评论》：国际纯粹与应用生物物理学联合会的官方期刊。
IF 4.9
Biophysical reviews Pub Date : 2024-08-27 eCollection Date: 2024-08-01 DOI: 10.1007/s12551-024-01216-3
Wilma K Olson
{"title":"<i>Biophysical Reviews</i>: the official journal of the International Union for Pure and Applied Biophysics.","authors":"Wilma K Olson","doi":"10.1007/s12551-024-01216-3","DOIUrl":"10.1007/s12551-024-01216-3","url":null,"abstract":"<p><p>This editorial for Volume 16, Issue 4 of <i>Biophysical Reviews</i> highlights recent contributions to biophysics from many parts of the world. <i>Biophysical Reviews</i> is the official journal of the International Union for Pure and Applied Biophysics (IUPAB 2024). The international scope of the articles in the issue exemplifies the goals of IUPAB to organize worldwide advancements, co-operation, communication, and education in biophysics. The articles in the Issue are illustrative of the wide array of topics and quantitative approaches used by scientists from many fields to explore and understand how biology-indeed, all life-works.</p>","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"16 4","pages":"383-385"},"PeriodicalIF":4.9,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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