Biophysical reviews最新文献_第8页

Nonthermal fluctuations accelerate biomolecular motors. 非热波动加速生物分子马达。

IF 4.9

Biophysical reviews Pub Date : 2024-10-02 eCollection Date: 2024-10-01 DOI: 10.1007/s12551-024-01238-x

Takayuki Ariga

{"title":"Nonthermal fluctuations accelerate biomolecular motors.","authors":"Takayuki Ariga","doi":"10.1007/s12551-024-01238-x","DOIUrl":"https://doi.org/10.1007/s12551-024-01238-x","url":null,"abstract":"Intracellular transport is essential for maintaining cellular function. This process is driven by different mechanisms in prokaryotic and eukaryotic cells. In small prokaryotic cells, diffusion is the primary means of transport, while larger eukaryotic cells also rely on active transport by molecular motors such as kinesin and dynein. Recently, it has become evident that, in addition to diffusion based on thermal fluctuations (Brownian motion), which was conventionally considered a diffusion mechanism within living cells, nonthermal fluctuations generated by metabolic activities play a crucial role in intracellular diffusion. Similarly, while molecular motors have been proposed to exploit thermal fluctuations in the environment following the direct observation and manipulation of single molecules, they have also been reported to utilize nonthermal fluctuations in recent years. This review begins with a brief overview of the historical knowledge of diffusive intracellular transport, which has been extended from the thermal fluctuations to the nonthermal fluctuations generated by metabolic activity. It then introduces recent findings on how nonthermal fluctuations accelerate the motion of molecular motors and discusses future perspectives on the general effects of these fluctuations on molecules in living cells.","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"16 5","pages":"605-612"},"PeriodicalIF":4.9,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extreme-value analysis in nano-biological systems: applications and implications. 纳米生物系统中的极值分析：应用和意义。

IF 4.9

Biophysical reviews Pub Date : 2024-10-02 eCollection Date: 2024-10-01 DOI: 10.1007/s12551-024-01239-w

Kumiko Hayashi, Nobumichi Takamatsu, Shunki Takaramoto

{"title":"Extreme-value analysis in nano-biological systems: applications and implications.","authors":"Kumiko Hayashi, Nobumichi Takamatsu, Shunki Takaramoto","doi":"10.1007/s12551-024-01239-w","DOIUrl":"https://doi.org/10.1007/s12551-024-01239-w","url":null,"abstract":"Extreme value analysis (EVA) is a statistical method that studies the properties of extreme values of datasets, crucial for fields like engineering, meteorology, finance, insurance, and environmental science. EVA models extreme events using distributions such as Fréchet, Weibull, or Gumbel, aiding in risk prediction and management. This review explores EVA's application to nanoscale biological systems. Traditionally, biological research focuses on average values from repeated experiments. However, EVA offers insights into molecular mechanisms by examining extreme data points. We introduce EVA's concepts with simulations and review its use in studying motor protein movements within cells, highlighting the importance of in vivo analysis due to the complex intracellular environment. We suggest EVA as a tool for extracting motor proteins' physical properties in vivo and discuss its potential in other biological systems. While there have been only a few applications of EVA to biological systems, it holds promise for uncovering hidden properties in extreme data, promoting its broader application in life sciences.","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"16 5","pages":"571-579"},"PeriodicalIF":4.9,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dimensional reduction and adaptation-development-evolution relation in evolved biological systems. 进化生物系统的降维与适应-发展-进化关系。

IF 4.9

Biophysical reviews Pub Date : 2024-09-30 eCollection Date: 2024-10-01 DOI: 10.1007/s12551-024-01233-2

Kunihiko Kaneko

{"title":"Dimensional reduction and adaptation-development-evolution relation in evolved biological systems.","authors":"Kunihiko Kaneko","doi":"10.1007/s12551-024-01233-2","DOIUrl":"10.1007/s12551-024-01233-2","url":null,"abstract":"Living systems are complex and hierarchical, with diverse components at different scales, yet they sustain themselves, grow, and evolve over time. How can a theory of such complex biological states be developed? Here we note that for a hierarchical biological system to be robust, it must achieve consistency between micro-scale (e.g., molecular) and macro-scale (e.g., cellular) phenomena. This allows for a universal theory of adaptive change in cells based on biological robustness and consistency between cellular growth and molecular replication. Here, we show how adaptive changes in high-dimensional phenotypes (biological states) are constrained to low-dimensional space, leading to the derivation of a macroscopic law for cellular states. The theory is then extended to evolution, leading to proportionality between evolutionary and environmental responses, as well as proportionality between phenotypic variances due to noise and due to genetic changes. The universality of the results across several models and experiments is demonstrated. Then, by further extending the theory of evolutionary dimensional reduction to multicellular systems, the relationship between multicellular development and evolution, in particular, the developmental hourglass, is demonstrated. Finally, the possibility of collapse of dimensional reduction under nutrient limitation is discussed.","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"16 5","pages":"639-649"},"PeriodicalIF":4.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microtubule choreography: spindle self-organization during cell division. 微管编排：细胞分裂过程中的纺锤体自组织。

IF 4.9

Biophysical reviews Pub Date : 2024-09-30 eCollection Date: 2024-10-01 DOI: 10.1007/s12551-024-01236-z

Amruta Sridhara, Yuta Shimamoto

引用次数: 0

Unveiling the multifaceted potential of amyloid fibrils: from pathogenic myths to biotechnological marvels. 揭示淀粉样蛋白原纤维的多方面潜力：从致病神话到生物技术奇迹。

IF 4.9

Biophysical reviews Pub Date : 2024-09-30 eCollection Date: 2024-12-01 DOI: 10.1007/s12551-024-01232-3

Gauri Tyagi, Shinjinee Sengupta

{"title":"Unveiling the multifaceted potential of amyloid fibrils: from pathogenic myths to biotechnological marvels.","authors":"Gauri Tyagi, Shinjinee Sengupta","doi":"10.1007/s12551-024-01232-3","DOIUrl":"10.1007/s12551-024-01232-3","url":null,"abstract":"Amyloid fibrils, historically stigmatized due to their association with diseases like Alzheimer's and Parkinson's, are now recognized as a distinct class of functional proteins with extraordinary potential. These highly ordered, cross-β-sheet protein aggregates are found across all domains of life, playing crucial physiological roles. In bacteria, functional amyloids like curli fibers are essential for surface adhesion, biofilm formation, and viral DNA packaging. Fungal prions exploit amyloid conformations to regulate translation, metabolism, and virulence, while mammalian amyloids are integral to melanin synthesis, hormone storage, and antimicrobial defense. The stability and hydrophobic nature of amyloid scaffolds underpin these diverse biological functions. Beyond their natural roles, amyloid fibrils offer unique capabilities in biomedicine, nanotechnology, and materials science. Their exceptional mechanical strength and biocompatibility make them ideal for controlled drug delivery, tissue engineering scaffolds, and enzyme immobilization. The intrinsic fluorescence and optical properties of certain amyloids open up innovative applications in biosensors, molecular probes, and optoelectronic devices. Furthermore, amyloid fibrils can template metal nanowires, enhance conducting materials, and form nanocomposites by integrating with polymers. This newfound appreciation for the functional diversity of amyloids has ignited intense research efforts to elucidate their molecular mechanisms, stability, and tunable properties. By unraveling the structural intricacies of functional amyloids, researchers aim to harness their remarkable attributes for groundbreaking biomedical therapies, advanced nanomaterials, and sustainable biotechnological innovations. This review explores the transformative journey of amyloids from pathological entities to biotechnological marvels, highlighting their vast potential across agriculture, environmental remediation, and industrial processes.","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"16 6","pages":"737-751"},"PeriodicalIF":4.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Force generation and resistance in human mitosis. 人类有丝分裂中的力产生和阻力。

IF 4.9

Biophysical reviews Pub Date : 2024-09-28 eCollection Date: 2024-10-01 DOI: 10.1007/s12551-024-01235-0

Colleen C Caldwell, Tinka V M Clement, Gijs J L Wuite

{"title":"Force generation and resistance in human mitosis.","authors":"Colleen C Caldwell, Tinka V M Clement, Gijs J L Wuite","doi":"10.1007/s12551-024-01235-0","DOIUrl":"https://doi.org/10.1007/s12551-024-01235-0","url":null,"abstract":"Since the first observations of chromosome segregation over 150 years ago, efforts to observe the forces that drive mitosis have evolved alongside advances in microscopy. The mitotic spindle acts as the major generator of force through the highly regulated polymerization and depolymerization of microtubules as well as associated motor proteins. Centromeric chromatin, along with associated proteins including cohesin and condensin, is organized to resist these forces and ensure accurate chromosome segregation. Microtubules and centromeric chromatin join at the kinetochore, a complex protein superstructure. Ongoing research into the forces generated at the kinetochore-microtubule interface has resulted in a range of estimates for forces necessary to separate chromosomes, from tens to hundreds of piconewtons. Still, the exact magnitude and regulation of these forces remain areas of continuing investigation. Determining the precise forces involved in chromosome segregation is hindered by limitations of current measurement techniques, but advances such as optical tweezers combined with fluorescence microscopy are promising for future research.","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"16 5","pages":"551-562"},"PeriodicalIF":4.9,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in label-free imaging techniques based on nonlinear optical microscopy to reveal the heterogeneity of the tumor microenvironment. 基于非线性光学显微镜的无标记成像技术的最新进展揭示肿瘤微环境的异质性。

IF 4.9

Biophysical reviews Pub Date : 2024-09-28 eCollection Date: 2024-10-01 DOI: 10.1007/s12551-024-01229-y

Ishita Chakraborty, Nirmal Mazumder, Ankur Gogoi, Ming-Chi Chen, Guan Yu Zhuo

{"title":"Recent advances in label-free imaging techniques based on nonlinear optical microscopy to reveal the heterogeneity of the tumor microenvironment.","authors":"Ishita Chakraborty, Nirmal Mazumder, Ankur Gogoi, Ming-Chi Chen, Guan Yu Zhuo","doi":"10.1007/s12551-024-01229-y","DOIUrl":"https://doi.org/10.1007/s12551-024-01229-y","url":null,"abstract":"The tumor microenvironment (TME) is a complex and dynamic network that significantly influences cancer progression. Understanding its intricate components, including the extracellular matrix (ECM), stromal cells, immune cells, and vascular endothelial cells, is crucial for developing effective cancer therapies. Conventional diagnostic methods, while essential, have limitations in sensitivity, specificity, and invasiveness. Label-free multimodal nonlinear optical (MNLO) microscopy offers a promising alternative, enabling detailed imaging without external labels. Techniques such as second harmonic generation (SHG), third harmonic generation (THG), coherent anti-Stokes Raman scattering (CARS), and two-photon fluorescence (TPF) provide complementary insights into the TME. SHG is particularly effective for imaging collagen fibers, while CARS highlights lipid-rich structures, and THG and TPF offer high-resolution imaging of cellular and subcellular structures. These modalities reveal crucial information about tumor progression, including changes in collagen organization and lipid metabolism, and allow for the study of cellular interactions and ECM remodeling. Multimodal setups, combining SHG, CARS, THG, and TPF, enable comprehensive analysis of the TME, facilitating the identification of early-stage cancerous changes and tracking of tumor progression. Despite the advantages of MNLO microscopy, such as reduced photodamage and the ability to image live tissues, challenges remain, including the complexity and cost of the setups. Addressing these challenges through technological advancements and optimization can enhance the applicability of MNLO microscopy in clinical diagnostics and cancer research, ultimately contributing to improved cancer diagnosis, prognosis, and treatment strategies.","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"16 5","pages":"581-590"},"PeriodicalIF":4.9,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of SDF-1 (CXCL12) gene in health and disease: a review of literature. SDF-1 （CXCL12）基因在健康和疾病中的影响：文献综述。

IF 4.9

Biophysical reviews Pub Date : 2024-09-27 eCollection Date: 2025-02-01 DOI: 10.1007/s12551-024-01230-5

Shruti Biyani, Amol Patil, Vinit Swami

{"title":"The influence of SDF-1 (CXCL12) gene in health and disease: a review of literature.","authors":"Shruti Biyani, Amol Patil, Vinit Swami","doi":"10.1007/s12551-024-01230-5","DOIUrl":"10.1007/s12551-024-01230-5","url":null,"abstract":"C-X-C motif chemokine ligand 12 (CXCL12), often referred to as stromal cell-derived factor 1 (SDF-1), is a crucial factor for musculoskeletal biology. SDF-1 is a powerful chemokine that has been shown to have a significant impact on a variety of physiological functions, including tissue repair, homeostasis maintenance, and embryonic development. SDF-1 plays a dominant role in bone and cartilage metabolism. It directs mesenchymal stem cell migration, controls osteogenesis and chondrogenesis, promotes angiogenesis, and modifies the inflammatory environment. SDF-1 also acts as an inflammatory chemokine during joint inflammation, recruiting inflammatory mediators to act and cause bone and cartilage degradation, thus causing osteoarthritis. Age-related bone loss and osteoporosis is exacerbated by SDF-1, which is elevated in the peripheral circulation due to a phenomenon known as \"senescence associated secretory phenotype\" of SDF-1. SDF-1 is also implicated in cancer metastasis causing the spread of secondary malignancies. Thus, the aim of this review is to explore the complex methods by which SDF-1 affects the fine equilibrium of bone and cartilage metabolism, providing insight into its importance in both healthy and diseased conditions.","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":"17 1","pages":"127-138"},"PeriodicalIF":4.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A commentary on the 21st IUPAB/62ND BSJ Congress at Kyoto June 24-28, 2024. 第二十一届IUPAB/第六十二届BSJ大会评论，于2024年6月24日至28日在京都举行。

IF 4.9

Biophysical reviews Pub Date : 2024-09-26 eCollection Date: 2024-10-01 DOI: 10.1007/s12551-024-01237-y

Manuel Prieto

引用次数: 0

Efforts for younger generations: the Biophysical Society of Japan and IUPAB2024. 为年轻一代的努力：日本生物物理学会和IUPAB2024。

IF 4.9

Biophysical reviews Pub Date : 2024-09-26 eCollection Date: 2024-10-01 DOI: 10.1007/s12551-024-01227-0

Satoshi Takahashi

引用次数: 0