Biophysical reviews最新文献_第7页

Phthalocyanine aggregates in the photodynamic therapy: dogmas, controversies, and future prospects 光动力疗法中的酞菁聚集体:教条、争议和未来展望

Biophysical reviews Pub Date : 2023-09-15 DOI: 10.1007/s12551-023-01129-7

Dmitry A. Bunin, Alexander G. Martynov, Daniil A. Gvozdev, Yulia G. Gorbunova

引用次数: 1

Mechanisms of UV-induced human lymphocyte apoptosis 紫外线诱导人淋巴细胞凋亡的机制

Biophysical reviews Pub Date : 2023-09-14 DOI: 10.1007/s12551-023-01142-w

M.A. Nakvasina, M.G. Holyavka, V.G. Artyukhov, M.S. Radchenko, O.V. Lidokhova

引用次数: 1

Review on brain-computer interface technologies in healthcare 医疗卫生领域脑机接口技术研究进展

Biophysical reviews Pub Date : 2023-09-14 DOI: 10.1007/s12551-023-01138-6

Evelyn Karikari, Konstantin A. Koshechkin

引用次数: 1

The critical role of mitochondrial lipid peroxidation in ferroptosis: insights from recent studies 线粒体脂质过氧化在铁下垂中的关键作用:来自最近研究的见解

Biophysical reviews Pub Date : 2023-09-13 DOI: 10.1007/s12551-023-01126-w

Konstantin G. Lyamzaev, Alisa A. Panteleeva, Ruben A. Simonyan, Armine V. Avetisyan, Boris V. Chernyak

引用次数: 1

The multi-faceted roles of R2TP complex span across regulation of gene expression, translation, and protein functional assembly R2TP复合体在基因表达、翻译和蛋白质功能组装方面发挥着多方面的作用

Biophysical reviews Pub Date : 2023-09-12 DOI: 10.1007/s12551-023-01127-9

Sifiso Duncan Luthuli, Addmore Shonhai

{"title":"The multi-faceted roles of R2TP complex span across regulation of gene expression, translation, and protein functional assembly","authors":"Sifiso Duncan Luthuli, Addmore Shonhai","doi":"10.1007/s12551-023-01127-9","DOIUrl":"https://doi.org/10.1007/s12551-023-01127-9","url":null,"abstract":"Abstract Macromolecular complexes play essential roles in various cellular processes. The assembly of macromolecular assemblies within the cell must overcome barriers imposed by a crowded cellular environment which is characterized by an estimated concentration of biological macromolecules amounting to 100–450 g/L that take up approximately 5–40% of the cytoplasmic volume. The formation of the macromolecular assemblies is facilitated by molecular chaperones in cooperation with their co-chaperones. The R2TP protein complex has emerged as a co-chaperone of Hsp90 that plays an important role in macromolecular assembly. The R2TP complex is composed of a heterodimer of RPAP3:P1H1DI that is in turn complexed to members of the ATPase associated with diverse cellular activities (AAA +), RUVBL1 and RUVBL2 (R1 and R2) families. What makes the R2TP co-chaperone complex particularly important is that it is involved in a wide variety of cellular processes including gene expression, translation, co-translational complex assembly, and posttranslational protein complex formation. The functional versatility of the R2TP co-chaperone complex makes it central to cellular development; hence, it is implicated in various human diseases. In addition, their roles in the development of infectious disease agents has become of interest. In the current review, we discuss the roles of these proteins as co-chaperones regulating Hsp90 and its partnership with Hsp70. Furthermore, we highlight the structure–function features of the individual proteins within the R2TP complex and describe their roles in various cellular processes.","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135878326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of DNA architecture of bacteria under various types of stress, methodological approaches, problems, and solutions. 在各种压力下细菌DNA结构的测定、方法、问题和解决方案

IF 4.9

Biophysical reviews Pub Date : 2023-09-08 eCollection Date: 2023-10-01 DOI: 10.1007/s12551-023-01122-0

Yu F Krupyanskii

{"title":"Determination of DNA architecture of bacteria under various types of stress, methodological approaches, problems, and solutions.","authors":"Yu F Krupyanskii","doi":"10.1007/s12551-023-01122-0","DOIUrl":"10.1007/s12551-023-01122-0","url":null,"abstract":"Actively growing cells maintain a dynamic, far from equilibrium order through metabolism. Under starvation stress or under stress of exposure to the analog of the anabiosis autoinducer (4-hexylresorcinol), cells go into a dormant state (almost complete lack of metabolism) or even into a mummified state. In a dormant state, cells are forced to use the physical mechanisms of DNA protection. The architecture of DNA in the dormant and mummified state of cells was studied by x-ray diffraction of synchrotron radiation and transmission electron microscopy (TEM). Diffraction experiments indicate the appearance of an ordered organization of DNA. TEM made it possible to visualize the type of DNA ordering. Intracellular nanocrystalline, liquid-crystalline, and folded nucleosome-like structures of DNA have been found. The structure of DNA within a cell in an anabiotic dormant state and dormant state (starvation stress) coincides (forms nanocrystalline structures). Data suggest the universality of DNA condensation by a protein Dps for a dormant state, regardless of the type of stress. The mummified state is very different in structure from the dormant state (has no ordering within a cell). It turned out that it is possible to visualize DNA conformation in toroidal and liquid crystal structures in which there is either no or a very small amount of the Dps protein. Observation of the DNA conformation in nanocrystals and folded nucleosome-like structures so far has been inconclusive. The methodological advances described will facilitate high-resolution visualization of the DNA conformation in the near future.","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44752412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primitive membraneless compartments as a window into the earliest cells. 原始的无膜隔室是进入最早细胞的窗口

IF 4.9

Biophysical reviews Pub Date : 2023-09-08 eCollection Date: 2023-12-01 DOI: 10.1007/s12551-023-01135-9

Tony Z Jia

引用次数: 0

Tools for microbial single-cell genomics for obtaining uncultured microbial genomes. 用于获得未培养微生物基因组的微生物单细胞基因组学工具

Biophysical reviews Pub Date : 2023-09-08 eCollection Date: 2024-02-01 DOI: 10.1007/s12551-023-01124-y

Masahito Hosokawa, Yohei Nishikawa

{"title":"Tools for microbial single-cell genomics for obtaining uncultured microbial genomes.","authors":"Masahito Hosokawa, Yohei Nishikawa","doi":"10.1007/s12551-023-01124-y","DOIUrl":"10.1007/s12551-023-01124-y","url":null,"abstract":"The advent of next-generation sequencing technologies has facilitated the acquisition of large amounts of DNA sequence data at a relatively low cost, leading to numerous breakthroughs in decoding microbial genomes. Among the various genome sequencing activities, metagenomic analysis, which entails the direct analysis of uncultured microbial DNA, has had a profound impact on microbiome research and has emerged as an indispensable technology in this field. Despite its valuable contributions, metagenomic analysis is a \"bulk analysis\" technique that analyzes samples containing a wide diversity of microbes, such as bacteria, yielding information that is averaged across the entire microbial population. In order to gain a deeper understanding of the heterogeneous nature of the microbial world, there is a growing need for single-cell analysis, similar to its use in human cell biology. With this paradigm shift in mind, comprehensive single-cell genomics technology has become a much-anticipated innovation that is now poised to revolutionize microbiome research. It has the potential to enable the discovery of differences at the strain level and to facilitate a more comprehensive examination of microbial ecosystems. In this review, we summarize the current state-of-the-art in microbial single-cell genomics, highlighting the potential impact of this technology on our understanding of the microbial world. The successful implementation of this technology is expected to have a profound impact in the field, leading to new discoveries and insights into the diversity and evolution of microbes.","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10937852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48393548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein-DNA recognition mechanisms and specificity. 蛋白质- dna识别机制和特异性

IF 4.9

Biophysical reviews Pub Date : 2023-09-07 eCollection Date: 2023-10-01 DOI: 10.1007/s12551-023-01137-7

Anastasia A Anashkina

引用次数: 0

Water as a sensor of weak impacts on biological systems. 水作为对生物系统影响微弱的传感器

IF 4.9

Biophysical reviews Pub Date : 2023-09-07 eCollection Date: 2023-10-01 DOI: 10.1007/s12551-023-01120-2

Valentin I Lobyshev

{"title":"Water as a sensor of weak impacts on biological systems.","authors":"Valentin I Lobyshev","doi":"10.1007/s12551-023-01120-2","DOIUrl":"10.1007/s12551-023-01120-2","url":null,"abstract":"A characteristic feature of weak impacts is the non-monotonic response of living organisms and model biological systems to monotonically decreasing impacts. The qualitative similarity of the effects caused by the different acting factors makes one think about the common cause of the observed effects, which is water. A comprehensive analysis of the actual composition of water indicates that water under normal conditions is a multicomponent open non-equilibrium system. Nanobubbles that are always present in water play a significant role in the properties of dilute aqueous solutions. When collapsed, they can produce active oxygen and nitrogen species that have a strong effect on biological systems. Significant non-monotonic changes in electrical conductivity found in a series of sequentially diluted solutions subjected to vigorous shaking after each dilution convincingly demonstrate the presence of chemical changes in the composition of aqueous solutions explained by mechanochemical processes. Similar changes were observed in water samples prepared in the same manner with vigorous shaking and dilution without the addition of any chemical compounds. The long-term evolution of the conductivity of such solutions depends on the chemical structure of the solutes.","PeriodicalId":9094,"journal":{"name":"Biophysical reviews","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42625949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0