流体流动的生物传感-来自PIEZO1的教训。

IF 4.9 Q1 BIOPHYSICS

Biophysical reviews Pub Date : 2024-10-04 eCollection Date: 2024-12-01 DOI:10.1007/s12551-024-01246-x

David J Beech, Charline Fagnen, Antreas C Kalli

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引用次数: 0

摘要

血液和淋巴管的内皮细胞是脊椎动物必不可少的。虽然机制在许多方面仍然是神秘的，但通过分子生物学研究，几个关键成分变得明显。在本文中，我们将重点放在PIEZO1上，它形成了不寻常的力传感离子通道，能够将力快速转导为生物效应。我们描述当前的知识和新出现的挑战。我们建议使用计算来构建内皮细胞的流量传感机制，以促进理解，发展可测试的假设，并有可能设计新的治疗策略和合成流量传感装置。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biological sensing of fluid flow-lessons from PIEZO1.

The flow sensing endothelial cell lining of blood and lymphatic vessels is essential in vertebrates. While the mechanisms are still mysterious in many regards, several critical components became apparent through molecular biology studies. In this article, we focus on PIEZO1, which forms unusual force-sensing ion channels capable of rapid transduction of force into biological effect. We describe current knowledge and emerging challenges. We suggest the idea of using computation to construct the flow sensing mechanism of endothelium to advance understanding, develop testable hypotheses and potentially design novel therapeutic strategies and synthetic flow sensing devices.

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来源期刊

Biophysical reviews Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

8.90

自引率

0.00%

发文量

期刊介绍： Biophysical Reviews aims to publish critical and timely reviews from key figures in the field of biophysics. The bulk of the reviews that are currently published are from invited authors, but the journal is also open for non-solicited reviews. Interested authors are encouraged to discuss the possibility of contributing a review with the Editor-in-Chief prior to submission. Through publishing reviews on biophysics, the editors of the journal hope to illustrate the great power and potential of physical techniques in the biological sciences, they aim to stimulate the discussion and promote further research and would like to educate and enthuse basic researcher scientists and students of biophysics. Biophysical Reviews covers the entire field of biophysics, generally defined as the science of describing and defining biological phenomenon using the concepts and the techniques of physics. This includes but is not limited by such areas as: - Bioinformatics - Biophysical methods and instrumentation - Medical biophysics - Biosystems - Cell biophysics and organization - Macromolecules: dynamics, structures and interactions - Single molecule biophysics - Membrane biophysics, channels and transportation