Brain injury最新文献

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Cathodal transcranial direct current stimulation for upper extremity functional rehabilitation in stroke survivors: a meta-analysis of parallel randomized controlled trials. 经颅阴极直流电刺激对中风幸存者上肢功能康复的影响:一项平行随机对照试验的荟萃分析。
IF 1.5 4区 医学
Brain injury Pub Date : 2026-09-01 Epub Date: 2026-08-18 DOI: 10.1080/02699052.2026.2720336
Jiangmei Chen, Liqiang Yu, Fang Liu, Qiaoling Chen, Shuang Jin
{"title":"Cathodal transcranial direct current stimulation for upper extremity functional rehabilitation in stroke survivors: a meta-analysis of parallel randomized controlled trials.","authors":"Jiangmei Chen, Liqiang Yu, Fang Liu, Qiaoling Chen, Shuang Jin","doi":"10.1080/02699052.2026.2720336","DOIUrl":"10.1080/02699052.2026.2720336","url":null,"abstract":"<p><strong>Background: </strong>Upper extremity motor dysfunction is common after stroke. Based on the inter-hemispheric inhibition model, cathodal transcranial direct current stimulation (c-tDCS) applied over the contralesional primary motor cortex (M1) is a promising adjuvant neuromodulation, but high-quality evidence for its efficacy, optimal parameters, and safety remains limited.</p><p><strong>Methods: </strong>We searched 10 databases through January 25, 2026, for parallel randomized controlled trials (RCTs). Methodological quality was assessed using Cochrane Risk of Bias 2.0, and meta-analyses were performed using RevMan 5.4 and Stata/SE 15.1.</p><p><strong>Results: </strong>Twenty-six RCTs (1038 patients) were included. Compared with controls, c-tDCS significantly improved upper extremity motor function, manual dexterity, and daily living activities, while also reducing elbow spasticity and overall neurological impairment (all <i>p</i> < 0.05). Resting motor threshold remained unchanged. Subgroup analyses showed stable efficacy at 1-2 mA, 20 min/session, 5 sessions/week, and ≥2 weeks of treatment. Short-term benefits were preserved, while long-term durability needs verification. Adverse events were mild and transient, mainly local tingling and itching.</p><p><strong>Conclusions: </strong>Adjuvant c-tDCS improves upper limb motor function, daily living activities, elbow spasticity, and global neurological status in stroke survivors, with favorable safety and short-term durability. A regimen of 1-2 mA for 20 min, 5 sessions/week for ≥2 weeks is recommended.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1054-1068"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A scoping review of therapies to support marriages and partnerships after acquired brain injury. 获得性脑损伤后支持婚姻和伙伴关系的治疗方法的范围审查。
IF 1.5 4区 医学
Brain injury Pub Date : 2026-09-01 Epub Date: 2026-08-06 DOI: 10.1080/02699052.2026.2713030
Gerard A Riley, Urszula Gajewska
{"title":"A scoping review of therapies to support marriages and partnerships after acquired brain injury.","authors":"Gerard A Riley, Urszula Gajewska","doi":"10.1080/02699052.2026.2713030","DOIUrl":"10.1080/02699052.2026.2713030","url":null,"abstract":"<p><strong>Background: </strong>Acquired brain injury (ABI) can undermine marriages/partnerships. Couples need access to relationship therapies proven to be effective in a brain injury context.</p><p><strong>Objective: </strong>To provide an overview of relationship therapies evaluated for use in ABI.</p><p><strong>Methods: </strong>Six databases were searched for studies that evaluated the impact on the relationship of interventions that were, at least partly, intended to improve the relationship.</p><p><strong>Results: </strong>Twenty-seven papers were included. Some reported the use of therapies widely used with other populations (family therapy, emotion-focused therapy, behavioral couples therapy). Others involved a structured curriculum specifically designed for use with couples living with ABI and focused on education and skills training. Most therapies also addressed non-relational issues. Couples tended to be middle-aged, White, and heterosexual. Studies generally used weak designs, and there were only six randomized controlled trials. Of 24 outcomes reported by these RCTs, all but three were classed as showing no effect or small improvement.</p><p><strong>Conclusions: </strong>Therapies would benefit from further development to ensure better outcomes, in part by ensuring that sufficient therapeutic time is allocated and that all the relational issues of concern to the couple are addressed. More inclusive samples and stronger designs would also help.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1019-1040"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Altered Temporal dynamics of resting-state EEG microstates as a neural signature of impaired consciousness: a high-density EEG analysis in chronic disorders of consciousness. 静息状态脑电图微态的时间动态变化作为意识受损的神经特征:慢性意识障碍的高密度脑电图分析。
IF 1.5 4区 医学
Brain injury Pub Date : 2026-09-01 Epub Date: 2026-08-05 DOI: 10.1080/02699052.2026.2707614
Xu Dong, Dan Wang, Jiajia Hou, Peipei Wang, Xue Jian, Tao Feng
{"title":"Altered Temporal dynamics of resting-state EEG microstates as a neural signature of impaired consciousness: a high-density EEG analysis in chronic disorders of consciousness.","authors":"Xu Dong, Dan Wang, Jiajia Hou, Peipei Wang, Xue Jian, Tao Feng","doi":"10.1080/02699052.2026.2707614","DOIUrl":"10.1080/02699052.2026.2707614","url":null,"abstract":"<p><strong>Primary objective: </strong>To differentiate Unresponsive Wakefulness Syndrome (UWS) from Minimally Conscious State (MCS) using EEG microstates.</p><p><strong>Research design: </strong>Retrospective analysis of high-density resting-state EEG.</p><p><strong>Methods and procedures: </strong>We analyzed EEG from 20 UWS, 22 MCS patients, and 20 controls. Microstate topographies were clustered into four canonical classes. To prevent machine learning data leakage, a fixed, label-independent template basis derived solely from healthy controls was utilized for back-fitting across all individuals. After optimizing template back-fitting and systematically controlling for group-dependent spatial map distortions via class-specific spatial correlation (SC) analysis, robust temporal parameters were extracted. A strictly contained Leave-One-Subject-Out Cross-Validation (LOOCV) multivariate logistic regression model was then applied.</p><p><strong>Main outcomes and results: </strong>Class D coverage progressively degraded (HC > MCS > UWS; <i>p</i> < 0.001) and correlated robustly with Coma Recovery Scale-Revised scores (ρ =0.84). Class C paradoxically increased in UWS. The multivariate LOOCV model accurately distinguished MCS from UWS (AUC = 0.97).</p><p><strong>Conclusions: </strong>The selective collapse of Class D alongside Class C retention signifies severe frontoparietal decoupling. Cross-validated microstate dynamics serve as specific bedside biomarkers for prognostic stratification, empirically supporting the Global Neuronal Workspace and Mesocircuit hypotheses.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1077-1086"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurostimulant use to facilitate recovery after traumatic brain injury in an adolescent patient with preexisting ADHD: a case report. 神经兴奋剂的使用,以促进恢复创伤性脑损伤后的青少年患者先前存在的注意力缺陷多动障碍:一个案例报告。
IF 1.5 4区 医学
Brain injury Pub Date : 2026-09-01 Epub Date: 2026-08-10 DOI: 10.1080/02699052.2026.2715504
Samantha N Koerber, Andrea Zuzarte, Neha Anand, Jaimie Hearn, Kilby Mann
{"title":"Neurostimulant use to facilitate recovery after traumatic brain injury in an adolescent patient with preexisting ADHD: a case report.","authors":"Samantha N Koerber, Andrea Zuzarte, Neha Anand, Jaimie Hearn, Kilby Mann","doi":"10.1080/02699052.2026.2715504","DOIUrl":"10.1080/02699052.2026.2715504","url":null,"abstract":"<p><strong>Background: </strong>Neurostimulants are commonly used after traumatic brain injury (TBI) to improve arousal, attention, and participation in rehabilitation. However, little is known about stimulant use among pediatric patients with preexisting attention-deficit/hyperactivity disorder (ADHD). We describe stimulant use to facilitate emergence from post-traumatic amnesia (PTA) in an adolescent with severe TBI and preexisting ADHD.</p><p><strong>Case presentation: </strong>A 14-year-old male with ADHD sustained a severe TBI with diffuse axonal injury following an electric scooter crash. He experienced prolonged PTA, severe agitation, and motor restlessness despite multimodal pharmacologic management and environmental interventions. On post-injury day 17, a trial of methylphenidate produced rapid improvements in attention and agitation. Agitated Behavior Scale scores subsequently decreased, and he emerged from PTA by post-injury day 23.</p><p><strong>Discussion: </strong>This case highlights a potential role for individualized neurostimulant therapy in facilitating recovery after severe TBI among adolescents with preexisting ADHD. To our knowledge, this is the first pediatric case in the literature describing stimulant use to facilitate emergence from PTA in a patient with preexisting ADHD. Further research is needed to establish evidence-based guidance for stimulant selection, dosing, and timing of re-initiation after pediatric TBI.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1125-1127"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential neuroprotective effects of resveratrol against traumatic brain injury in rodent models: a systematic review and meta-analysis. 白藜芦醇对啮齿动物创伤性脑损伤的潜在神经保护作用:一项系统综述和荟萃分析。
IF 1.5 4区 医学
Brain injury Pub Date : 2026-09-01 Epub Date: 2026-08-17 DOI: 10.1080/02699052.2026.2717720
Mahrokh Janmohamadi, Amirreza Peyrovinasab, Arash Sarveazad, Niyousha Rahimimovaghar, Vafa Rahimi-Movaghar, Mahmoud Yousefifard
{"title":"Potential neuroprotective effects of resveratrol against traumatic brain injury in rodent models: a systematic review and meta-analysis.","authors":"Mahrokh Janmohamadi, Amirreza Peyrovinasab, Arash Sarveazad, Niyousha Rahimimovaghar, Vafa Rahimi-Movaghar, Mahmoud Yousefifard","doi":"10.1080/02699052.2026.2717720","DOIUrl":"10.1080/02699052.2026.2717720","url":null,"abstract":"<p><strong>Background: </strong>Oxidative stress, inflammation, and apoptosis following traumatic brain injury (TBI) cause secondary damage that leads to long-term neurological impairments. Though its effectiveness in TBI remains largely underexplored, the natural polyphenol resveratrol (RES) shows neuroprotective effects. This meta-analysis assesses RES's therapeutic potential in rodent TBI models.</p><p><strong>Methods: </strong>Medline, Embase, Scopus, and Web of Science (up to April 2025) were searched for studies evaluating RES in rodent TBI using PRISMA recommendations. Inclusion criteria were satisfied by 10 studies. Outcomes included cerebral edema, autophagy, inflammation, apoptosis, neuronal density, and neurological status. With 95% confidence intervals, random-effects models computed standardized mean differences. We looked at publication bias (Egger's test) and heterogeneity (I<sup>2</sup>).</p><p><strong>Results: </strong>RES notably lowered autophagy markers (Beclin-1; LC3II) and cerebral edema. It decreased apoptosis (caspase-3) and inflammation (IL-1β; TNF-α). In CA1 and CA3 areas, hippocampal neuron density increased. With lower escape latency in the Morris water maze and Neurological Severity Score, memory and neurological status improved.</p><p><strong>Conclusion: </strong>By reducing edema, inflammation, and apoptosis, RES shows strong neuroprotection in rodent TBI models while maintaining neurons and improving recovery. RES is a reasonable contender for supplementary TBI treatment.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1041-1053"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of protocol-driven care with complication rates in severe traumatic brain injury: a two-hospital quasi-experimental study in a resource-limited setting. 重度创伤性脑损伤方案驱动型护理与并发症发生率的关联:一项资源有限环境下两家医院的准实验研究
IF 1.5 4区 医学
Brain injury Pub Date : 2026-09-01 Epub Date: 2026-08-02 DOI: 10.1080/02699052.2026.2710725
Jalil I Hussein, Younus Khudhur Baeez
{"title":"Association of protocol-driven care with complication rates in severe traumatic brain injury: a two-hospital quasi-experimental study in a resource-limited setting.","authors":"Jalil I Hussein, Younus Khudhur Baeez","doi":"10.1080/02699052.2026.2710725","DOIUrl":"10.1080/02699052.2026.2710725","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the impact of implementing Brain Trauma Foundation (BTF) guidelines on complication rates and clinical outcomes in severe traumatic brain injury (STBI) in a resource-limited setting.</p><p><strong>Methods: </strong>A quasi-experimental study (<i>n</i> = 70) was conducted in a resource-limited setting. Control group (<i>n</i> = 35) received routine care; study group (<i>n</i> = 35) was managed according to BTF guidelines. Complications (fever, pressure ulcers, hyperglycemia, infection, increased ICP) were collected daily. Outcomes included complication rates/severity, ventilation days, ICU stay, and Glasgow Outcome Scale Extended (GOSE).</p><p><strong>Results: </strong>The study group had significantly lower complication rates: fever (37.1% vs. 62.9%, <i>p</i> = 0.055), bed sores (5.7% vs. 31.4%, <i>p</i> = 0.0065), hyperglycemia (31.4% vs. 57.1%, <i>p</i> = 0.05), infection (20.0% vs. 51.4%, <i>p</i> = 0.01), and increased ICP (11.4% vs. 42.9%, <i>p</i> = 0.006). Mean complications per patient were lower (1.9 ± 1.2 vs. 2.8 ± 1.5, <i>p</i> = 0.006). Early surgery (48-72 h) was associated with lower complication rates. Complication occurrence strongly predicted unfavorable outcomes.</p><p><strong>Conclusions: </strong>Implementing BTF guidelines was associated with lower complication incidence and severity in STBI patients in a resource-limited setting. Protocol-driven care and early surgery were associated with fewer complications, which strongly predicted better functional outcomes.However, because the intervention and control groups were treated at different hospitals with differing resources, these findings should be interpreted as hypothesis-generating rather than causal.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1097-1106"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prospective validation of a non-invasive bedside protocol for tracheostomy decannulation in acquired brain injury with otolaryngologic concordance. 一种无创床边治疗合并耳鼻喉疾病的获得性脑损伤气管切开术的前瞻性验证。
IF 1.5 4区 医学
Brain injury Pub Date : 2026-09-01 Epub Date: 2026-08-26 DOI: 10.1080/02699052.2026.2720633
Sooraj Mavilakandy, Jacob George, Praveen Kumar Chinniah, Prashanth Chalageri, Madhavi Kandagaddala, Bindhu P Synthia
{"title":"Prospective validation of a non-invasive bedside protocol for tracheostomy decannulation in acquired brain injury with otolaryngologic concordance.","authors":"Sooraj Mavilakandy, Jacob George, Praveen Kumar Chinniah, Prashanth Chalageri, Madhavi Kandagaddala, Bindhu P Synthia","doi":"10.1080/02699052.2026.2720633","DOIUrl":"10.1080/02699052.2026.2720633","url":null,"abstract":"<p><strong>Background: </strong>Decannulation of tracheostomy in individuals with acquired brain injury (ABI) is challenging and often requires endoscopic airway assessment. A reliable noninvasive bedside protocol could support decision-making in neurorehabilitation settings.</p><p><strong>Methods: </strong>We conducted a prospective observational cohort study at a tertiary neurorehabilitation center between July 2021 and March 2025. Thirty-six adults with chronic ABI and tracheostomies were assessed using a structured bedside protocol comprising tracheostomy capping tolerance, suction requirement ≤2 episodes per 24 hours, modified Evans blue dye aspiration screening, and laryngeal ultrasonography. All participants subsequently underwent blinded nasopharyngolaryngoscopic (NPL) examination as the reference standard.</p><p><strong>Results: </strong>Twenty-six participants (72.2%) were protocol positive; 24 were suitable for decannulation on NPL and two were unsuitable. Among 10 protocol-negative participants, nine were unsuitable and one was suitable. Sensitivity was 96.0% (95% CI 79.6-99.9), specificity 81.8% (95% CI 48.2-97.7), and overall accuracy 91.7%. Agreement with NPL findings was strong (κ = 0.80). No aspiration pneumonia, respiratory deterioration, or recannulation occurred during four weeks of follow-up.</p><p><strong>Conclusions: </strong>The bedside protocol may serve as a screening tool to support decannulation assessment and guide the need for confirmatory endoscopic evaluation. Larger multicentre studies are warranted.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1115-1124"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148825219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-time measurement of daily participation in adults with TBI using EMA. 使用EMA实时测量成人TBI患者的日常参与情况。
IF 1.5 4区 医学
Brain injury Pub Date : 2026-09-01 Epub Date: 2026-07-28 DOI: 10.1080/02699052.2026.2708943
Rosalie Ellis, Allie J Tracey, Dennis Tirri, Amanda R Rabinowitz
{"title":"Real-time measurement of daily participation in adults with TBI using EMA.","authors":"Rosalie Ellis, Allie J Tracey, Dennis Tirri, Amanda R Rabinowitz","doi":"10.1080/02699052.2026.2708943","DOIUrl":"10.1080/02699052.2026.2708943","url":null,"abstract":"<p><strong>Purpose: </strong>Traumatic brain injury (TBI) reduces productivity, social participation, and life satisfaction. Ecological Momentary Assessment (EMA), which captures real-time experiences, may have advantages over traditional retrospective self-report measures.</p><p><strong>Methods: </strong>Thirty-four adults with moderate-to-severe TBI completed smartphone-based EMA surveys (5x/day for 4 weeks). EMA-derived variables indexed the proportion of prompts participants were home, alone, or engaged in productive or social activities. Retrospective measures (Participation Assessment with Recombined Tools-Objective [PART-O] and Satisfaction With Life Scale [SWLS]) were collected at baseline and 4 weeks later. We used Linear Mixed Effects Models to examine associations between EMA indicators and outcomes.</p><p><strong>Results: </strong>We did not observe a significant linear change in PART-O and SWLS scores; however, EMA-derived participation indicators demonstrated marked day-to-day variability, and were associated with PART-O scores-greater EMA-reported time engaged in productive activities with higher PART-O Summary, Productivity, and Social; greater EMA-reported time at home with lower PART-O Productivity; and greater EMA-reported time alone with lower PART-O Summary. No EMA indicators were significantly associated with SWLS.</p><p><strong>Conclusions: </strong>EMA-derived measures revealed substantial within and between-person variability, the latter of which was associated with scores on traditional participation measures, supporting the potential of EMA as a measure of participation patterns after TBI.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1087-1096"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of change during exposure therapy for persistent post-concussion symptoms: insights from session-level process data. 持续脑震荡后症状暴露治疗期间的改变机制:来自会话水平过程数据的见解。
IF 1.5 4区 医学
Brain injury Pub Date : 2026-09-01 Epub Date: 2026-07-22 DOI: 10.1080/02699052.2026.2705357
Skye King, Fenna Konings, Ieke Winkens, Joukje van der Naalt, Marleen Rijkeboer, Caroline van Heugten
{"title":"Mechanisms of change during exposure therapy for persistent post-concussion symptoms: insights from session-level process data.","authors":"Skye King, Fenna Konings, Ieke Winkens, Joukje van der Naalt, Marleen Rijkeboer, Caroline van Heugten","doi":"10.1080/02699052.2026.2705357","DOIUrl":"10.1080/02699052.2026.2705357","url":null,"abstract":"<p><strong>Background: </strong>Persistent post-concussion symptoms affect a substantial subgroup of individuals following mild traumatic brain injury. Intensive exposure therapy may be an effective intervention by directly targeting psychological mechanisms underlying symptom maintenance. This study provides insight into the clinical processes of this therapy.</p><p><strong>Materials and methods: </strong>Therapy session-level data from two single-case experimental design studies with a total of eight participants was analyzed using mixed-methods.</p><p><strong>Results: </strong>The most frequently targeted feared expectations included: cognitive failure, task breakdown, catastrophic consequences of physical symptoms; and exposure tasks: cognitive challenges, sensory rich environments, social interaction. Quantitative analyses demonstrated a significant within-session reduction in belief strength about expected outcomes (mean decrease = 38.49, <i>p</i> < 0.001), with notable individual differences. Belief reduction was consistent across the exposure sessions. Despite observed reductions, participants often retained some concerns after therapy, most commonly due to generalization doubts or uncertainty under higher task demands.</p><p><strong>Conclusions: </strong>Findings highlight the multidimensional and personalized nature of feared beliefs in persistent symptoms and underscores the clinical value of individualized behavioral experiments. The study provides process-level insights that may inform more confident and targeted implementation of (intensive) exposure therapy in mild traumatic brain injury treatment.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1069-1076"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148547887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What happens when an athlete suffers a concussion outside of sport? An in-depth analysis of non-sport-related concussion in adolescent athletes. 当运动员在运动之外遭受脑震荡时会发生什么?青少年运动员非运动相关脑震荡的深入分析。
IF 1.5 4区 医学
Brain injury Pub Date : 2026-09-01 Epub Date: 2026-09-14 DOI: 10.1080/02699052.2026.2720631
Avi N Albert, Jai Horsey, Jordan Vanleuven, Maryam Jawid, Natasha Hughes, Michael Zargari, Kristen Williams, Douglas P Terry, Scott L Zuckerman
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