Brain injury最新文献

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Timing matters in acute on-pitch concussion assessment. 在急性场上脑震荡评估中,时机很重要。
IF 1.5 4区 医学
Brain injury Pub Date : 2026-10-01 DOI: 10.1080/02699052.2026.2743024
André Polli Fujita
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引用次数: 0
Health anxiety following subarachnoid hemorrhage: preliminary insights from a neuropsychology care pathway. 蛛网膜下腔出血后的健康焦虑:来自神经心理学护理途径的初步见解。
IF 1.5 4区 医学
Brain injury Pub Date : 2026-09-29 DOI: 10.1080/02699052.2026.2735355
Kealan Forristal, Caroline M van Heugten, David C Gillespie
{"title":"Health anxiety following subarachnoid hemorrhage: preliminary insights from a neuropsychology care pathway.","authors":"Kealan Forristal, Caroline M van Heugten, David C Gillespie","doi":"10.1080/02699052.2026.2735355","DOIUrl":"https://doi.org/10.1080/02699052.2026.2735355","url":null,"abstract":"<p><strong>Background: </strong>Psychological distress is common following subarachnoid hemorrhage (SAH). Although anxiety is frequently reported, specific subtypes have not been examined in this population. This study describes health anxiety and its association with psychosocial outcomes among individuals with SAH.</p><p><strong>Methods: </strong>A secondary analysis was conducted using routine follow-up data from a neuropsychology care pathway. Data from individuals with SAH (71 observations from 60 individuals; mean age = 63.46; 25% male; 72% aneurysmal SAH) were analyzed. Health anxiety was measured with the Short Health Anxiety Inventory (SHAI), alongside other psychosocial measurements. Descriptive statistics summarized SHAI scores, and hierarchical regressions examined psychosocial associations.</p><p><strong>Results: </strong>Twenty-eight percent scored ≥18 on the SHAI, 24% ≥20, and 10% ≥27. Demographic and clinical variables accounted for 5% of variance in SHAI scores; inclusion of somatic and psychosocial variables increased this to 88%. Only psychological distress was significantly associated with SHAI scores (<i>r</i> = .39, <i>p</i> < 0.01).</p><p><strong>Conclusions: </strong>Around one in four individuals reported elevated health anxiety, with 10% meeting the threshold for clinically significant symptoms. The strongest association was with psychological distress, suggesting health anxiety may represent a target for intervention. Further prospective studies are needed to replicate findings and better understand the role of health anxiety in this population.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-9"},"PeriodicalIF":1.5,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feasibility and preliminary validation of the LIBRA model among those with mild TBI. LIBRA模型在轻度TBI患者中的可行性及初步验证。
IF 1.5 4区 医学
Brain injury Pub Date : 2026-09-29 DOI: 10.1080/02699052.2026.2728032
Susan M Mingils, Christopher E Stamper, Molly E Penzenik, Jason B Gibbons, Matthew J Igo, Kelly A Stearns-Yoder, Kevin Beck, Christopher A Lowry, Andrew J Hoisington, Lisa A Brenner
{"title":"Feasibility and preliminary validation of the LIBRA model among those with mild TBI.","authors":"Susan M Mingils, Christopher E Stamper, Molly E Penzenik, Jason B Gibbons, Matthew J Igo, Kelly A Stearns-Yoder, Kevin Beck, Christopher A Lowry, Andrew J Hoisington, Lisa A Brenner","doi":"10.1080/02699052.2026.2728032","DOIUrl":"https://doi.org/10.1080/02699052.2026.2728032","url":null,"abstract":"<p><strong>Purpose/objective: </strong>Methods are needed to evaluate the influence of risk factors on post-injury brain health among those with mild traumatic brain injury (mTBI). We employed an existing model, the LIfestyle for BRAin Health (LIBRA), to demonstrate feasibility and establish initial validation with mTBI cohorts.</p><p><strong>Research method/design: </strong>Analyses of data from 17 civilians with acute mTBI (longitudinal) and 92 male United States Veterans with historical mTBI (cross-sectional). LIBRA scores were constructed; a higher score indicates greater risk to brain health. We also evaluated score distributions, the prevalence of LIBRA factors, and associations with non-LIBRA risk factors (initial validation).</p><p><strong>Results: </strong>Among those with acute mTBI (longitudinal), the mean ± standard deviation LIBRA score across all time points was 2.34 ± 3.19 (range -1.0 to +11.1). Individual scores were relatively stable across time, with some variability in physical activity and alcohol use. In Veterans with historical mTBI (cross-sectional), the mean LIBRA score was 3.92 ± 2.64 (range -1.0 to +10.3). The most prevalent risk factors were obesity and lifetime history of smoking followed by current depression. Initial validation findings were mixed.</p><p><strong>Conclusions/implications: </strong>Differences in LIBRA scores and other drivers of risk (non-LIBRA) across two mTBI cohorts (acute, historical) support the feasibility of implementation among those with a history of mTBI.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic role of hemoglobin-to-RDW ratio for clinical outcomes in traumatic brain injury patients admitted to the intensive care unit: a retrospective analysis. 血红蛋白与rdw比值对入住重症监护室的创伤性脑损伤患者临床结果的预后作用:回顾性分析。
IF 1.5 4区 医学
Brain injury Pub Date : 2026-09-22 DOI: 10.1080/02699052.2026.2735358
Kuan-Kai Lai, Chun-Man Kuo, Ching-Lin Chen
{"title":"Prognostic role of hemoglobin-to-RDW ratio for clinical outcomes in traumatic brain injury patients admitted to the intensive care unit: a retrospective analysis.","authors":"Kuan-Kai Lai, Chun-Man Kuo, Ching-Lin Chen","doi":"10.1080/02699052.2026.2735358","DOIUrl":"https://doi.org/10.1080/02699052.2026.2735358","url":null,"abstract":"<p><strong>Purpose: </strong>The hemoglobin-to-red cell distribution width ratio (HRR) has emerged as a potential biomarker in various clinical contexts, but its role in Traumatic brain injury (TBI) is unclear.</p><p><strong>Materials and methods: </strong>The records of adult patients with traffic-related TBI admitted to the ICU of a Level-I Trauma Center in Taiwan between 2016 and 2017 were retrospectively reviewed. Included patients had a Head and Neck Abbreviated Injury Scale (AIS) score ≥ 3. The primary outcomes were in-hospital mortality and prolonged hospital length of stay (LOS). Using the median HRR value of 1.057 as the cutoff, patients were categorized into the low HRR group and high HRR group.</p><p><strong>Results: </strong>A total of 105 patients were included in the analysis. Patients in the low HRR group were older, more likely to be female, and had a higher prevalence of diabetes. After adjusting for clinical variables, In the dichotomized analysis, the high HRR group had significantly lower odds of prolonged hospital LOS than the low HRR group after adjustment.</p><p><strong>Conclusions: </strong>A higher HRR was independently associated with a lower likelihood of prolonged hospital stay among patients with TBI admitted to the ICU. However, HRR was not significantly associated with in-hospital mortality after adjustment.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-7"},"PeriodicalIF":1.5,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychiatric comorbidities in people with and without post-traumatic epilepsy: a systematic review and meta-analysis. 创伤后癫痫患者和非创伤后癫痫患者的精神合并症:一项系统回顾和荟萃分析。
IF 1.5 4区 医学
Brain injury Pub Date : 2026-09-21 DOI: 10.1080/02699052.2026.2736707
Ali Rafati, Aditya Mittal, Churl-Su Kwon
{"title":"Psychiatric comorbidities in people with and without post-traumatic epilepsy: a systematic review and meta-analysis.","authors":"Ali Rafati, Aditya Mittal, Churl-Su Kwon","doi":"10.1080/02699052.2026.2736707","DOIUrl":"https://doi.org/10.1080/02699052.2026.2736707","url":null,"abstract":"<p><strong>Introduction: </strong>While both traumatic brain injury (TBI) and epilepsy are independently associated with psychiatric comorbidities, population-based evidence on the association between post-traumatic epilepsy (PTE) and psychiatric comorbidities is limited. We systematically reviewed psychiatric comorbidities in people with vs. without PTE.</p><p><strong>Methods: </strong>We followed PRISMA reporting standards. Records were searched until August 2026 from MEDLINE, Embase, and PsycINFO, and were included if reported psychiatric comorbidities among people with PTE compared to control groups of i) epilepsy, ii) TBI-no-epilepsy, and/or iii) no-TBI-no-epilepsy.</p><p><strong>Results: </strong>Of 1275 records identified, 6 were included. Sufficient data for meta-analysis was available only for depression. A pooled analysis of 2 studies on 81 people with PTE and 515 people with TBI-no-epilepsy showed no significantly different incidence proportion of depression between PTE and TBI-no-epilepsy (24/81[29.6%] vs. 121/515[23.4%]; RR:1.20 95%CI:0.83-1.74).</p><p><strong>Conclusion: </strong>Previous evidence is sparse. We observed no significant difference in depression incidence in PTE vs. TBI-no-epilepsy. Future research should explore psychiatric comorbidities in PTE vs. TBI-no-epilepsy, epilepsy-only, and healthy controls.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-7"},"PeriodicalIF":1.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Caspase-3 dependent, induction of barrier dysfunction and hyperpermeability in blood-brain barrier endothelial cells. Caspase-3依赖性,诱导血脑屏障内皮细胞屏障功能障碍和高通透性。
IF 1.5 4区 医学
Brain injury Pub Date : 2026-09-18 DOI: 10.1080/02699052.2026.2733592
Himakarnika Alluri, Rickesha L Wilson, Morgan Merriman, Chinchusha Anasooya Shaji, Chen Chen, Gabriela Seplovich, Devendra A Sawant, Chander Peddaboina, Jason H Huang, Binu Tharakan
{"title":"Caspase-3 dependent, induction of barrier dysfunction and hyperpermeability in blood-brain barrier endothelial cells.","authors":"Himakarnika Alluri, Rickesha L Wilson, Morgan Merriman, Chinchusha Anasooya Shaji, Chen Chen, Gabriela Seplovich, Devendra A Sawant, Chander Peddaboina, Jason H Huang, Binu Tharakan","doi":"10.1080/02699052.2026.2733592","DOIUrl":"https://doi.org/10.1080/02699052.2026.2733592","url":null,"abstract":"<p><strong>Background: </strong>Blood-brain barrier (BBB) dysfunction and associated microvascular hyperpermeability lead to brain edema and elevation of intracranial pressure in traumatic and ischemic brain injuries. Pro-inflammatory cytokines, interleukin (IL-1β) and tumor necrosis factor (TNF-α), are up-regulated in such conditions and serve as endogenous activators of caspase-3 and apoptosis. The objective of this study was to comparatively test how these cytokines regulate caspase-3-mediated BBB breakdown/hyperpermeability, and understand if these effects were cell death dependent.</p><p><strong>Methods: </strong>Rat brain microvascular endothelial cells were exposed to IL-1β, TNF-α, or caspase-3 activator, staurosporine (STS). Blood-brain barrier integrity and functions were determined by monolayer permeability, tight junction integrity, and cytoskeletal integrity. The changes in mitochondrial reactive oxygen species (ROS) and caspase-3 activity were evaluated microscopically and fluorometrically, respectively.</p><p><strong>Results: </strong>IL-1β, TNF-α, and STS induced caspase-3 activation, tight junction/cytoskeletal disorganization, and monolayer hyperpermeability. These effects were inhibited by a caspase-3 inhibitor, Z-DEVD-fmk. Treatments had no effect on ROS formation.</p><p><strong>Discussion: </strong>This comparative study shows that, in BBB endothelial cells, IL-1β, TNF-α, and STS induce tight junction/cytoskeletal disorganization and hyperpermeability via Caspase-3 mediated breakdown of the tight junction proteins. Effects are independent of ROS formation, one of the significant factors that promote blood-brain barrier dysfunctions in neurological disorders.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-9"},"PeriodicalIF":1.5,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148987965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developmental eye movement test performance and oculomotor dysfunction in adults with chronic mild traumatic brain injury. 成人慢性轻度创伤性脑损伤的发育性眼动测试表现和动眼肌功能障碍。
IF 1.5 4区 医学
Brain injury Pub Date : 2026-09-08 DOI: 10.1080/02699052.2026.2730261
Chuan Hu, Geeta Girdher, Thomas J DeGraba, Kimberly Meier
{"title":"Developmental eye movement test performance and oculomotor dysfunction in adults with chronic mild traumatic brain injury.","authors":"Chuan Hu, Geeta Girdher, Thomas J DeGraba, Kimberly Meier","doi":"10.1080/02699052.2026.2730261","DOIUrl":"https://doi.org/10.1080/02699052.2026.2730261","url":null,"abstract":"<p><strong>Purpose: </strong>Oculomotor dysfunction is common after mild traumatic brain injury (mTBI) and contributes to persistent visual symptoms. Comprehensive binocular vision and ocular motor assessments remain the diagnostic standard but may not be readily available. This study examined the association between DEM test performance and clinically diagnosed oculomotor dysfunction in active-duty military personnel with chronic mTBI.</p><p><strong>Methods: </strong>This retrospective cross-sectional study included military personnel enrolled in a 4-week Intensive Outpatient Program at the National Intrepid Center of Excellence between August 2024 and January 2025. Participants underwent a comprehensive vision assessment. DEM vertical time (VT), adjusted horizontal time (AHT), and Ratio were analyzed using age-adjusted regression models. Bootstrap-corrected ROC analysis was used to evaluate screening performance.</p><p><strong>Results: </strong>Analyses included 85 participants, of whom 30 (35%) had oculomotor dysfunction. Participants with oculomotor dysfunction had significantly longer AHT and VT, whereas the Ratio did not differ between groups. Age-adjusted total DEM time (AHT + VT) provided the best discrimination (optimism-corrected AUC = 0.70).</p><p><strong>Conclusions: </strong>Longer DEM completion times, but not the DEM Ratio, were associated with clinically diagnosed oculomotor dysfunction in adults with chronic mTBI. Total DEM time demonstrated moderate screening performance and may help identify individuals who warrant a comprehensive evaluation.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-8"},"PeriodicalIF":1.5,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex differences in concussion incidence before and during the COVID-19 pandemic: a population-based study (2017-2022). 2019冠状病毒病大流行之前和期间脑震荡发病率的性别差异:一项基于人群的研究(2017-2022)。
IF 1.5 4区 医学
Brain injury Pub Date : 2026-09-07 DOI: 10.1080/02699052.2026.2728033
Samaneh Chaychi, Mohsen Hadian, Charles Haskell Tator, Maria Carmela Tartaglia
{"title":"Sex differences in concussion incidence before and during the COVID-19 pandemic: a population-based study (2017-2022).","authors":"Samaneh Chaychi, Mohsen Hadian, Charles Haskell Tator, Maria Carmela Tartaglia","doi":"10.1080/02699052.2026.2728033","DOIUrl":"https://doi.org/10.1080/02699052.2026.2728033","url":null,"abstract":"<p><strong>Objectives: </strong>This population-based retrospective study investigated the impact of sex on annual case counts and incidence rates of concussions before and during COVID-19 pandemic.</p><p><strong>Methods: </strong>Using administrative data from ICES, we identified 393,397 individuals with concussion between April 2017 and March 2022 in the Province of Ontario, Canada. A one-year washout period (no concussion/head injury diagnosis in the prior 365 days) was employed to ensure new cases. Data were stratified by sex, age groups, and rurality comparing 2019 as the pre-pandemic period to 2020 a the pandemic period.</p><p><strong>Results: </strong>The pandemic led to a sharp decline in concussion rates for both sexes across all age groups. Annual case counts dropped from over 99,000 cases in pre-pandemic years to 33,693 in 2020 with the most significant reductions in school-aged children and adolescents. Despite the overall decline, the female share of diagnosed concussions increased modestly during the pandemic, with age-stratified analyses showing that sex-specific patterns varied across age groups. Poisson regression analysis revealed that females had a 16.8% higher concussion rate than males after adjusting for age and rurality.</p><p><strong>Conclusion: </strong>The pandemic significantly altered healthcare-recorded concussion patterns, likely reflecting both reduced exposure to injury risk and pandemic-related changes in healthcare-seeking and case capture. Our findings underscore the need to incorporate sex as a key variable in future concussion research and prevention strategies.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-9"},"PeriodicalIF":1.5,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examining longitudinal changes in alexithymia and depressive symptoms following acquired brain injury. 后天性脑损伤后述情障碍和抑郁症状的纵向变化
IF 1.5 4区 医学
Brain injury Pub Date : 2026-09-03 DOI: 10.1080/02699052.2026.2726455
Priscilla Prince, Kristin Naragon-Gainey, Rodrigo Becerra, Michael Weinborn, Carmela F Pestell
{"title":"Examining longitudinal changes in alexithymia and depressive symptoms following acquired brain injury.","authors":"Priscilla Prince, Kristin Naragon-Gainey, Rodrigo Becerra, Michael Weinborn, Carmela F Pestell","doi":"10.1080/02699052.2026.2726455","DOIUrl":"https://doi.org/10.1080/02699052.2026.2726455","url":null,"abstract":"<p><strong>Objective: </strong>Alexithymia and depressive symptoms are common following acquired brain injury (ABI). However, their longitudinal relationship remains unclear. This study examined trajectories of alexithymia and depressive symptoms over 24 months post-injury and tested their temporal associations.</p><p><strong>Methods: </strong>Adults with ABI (<i>N</i> = 116) (mean age = 44 years, 61% male, 82% moderate to severe ABI) were assessed at baseline (within two years post-injury), 3, 12, and 24 months using the Perth Alexithymia Questionnaire and the depression subscale of the Depression, Anxiety, Stress Scale. Bayesian latent growth models, and cross-lagged panel models were used to examine change, co-development, and directional relationships.</p><p><strong>Results: </strong>Mean alexithymia scores remained stable across timepoints, whereas depressive symptoms showed modest improvement. Both constructs exhibited moderate temporal stability, and were associated at baseline, demonstrating co-occurrence in early recovery. No consistent directional relationship was observed, and overall model fit was poor. Additionally, there was substantial missingness at 24 months (75%).</p><p><strong>Conclusion: </strong>These findings suggest that alexithymia is relatively stable in the first two years following ABI and commonly co-occurs with depressive symptoms early after injury. However, there is no clear longitudinal direction association. Early assessment of emotional processing and mood may help identify individuals at risk for ongoing psychological difficulties.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of transcranial Doppler and carotid ultrasound parameters with swallowing outcomes after endovascular thrombectomy for anterior circulation stroke. 经颅多普勒和颈动脉超声参数与前循环卒中血管内取栓术后吞咽结果的关系。
IF 1.5 4区 医学
Brain injury Pub Date : 2026-09-02 DOI: 10.1080/02699052.2026.2725666
Hung-Hsi Lin, Shu-Mei Yang, Ting-Ju Lai, Yen-Heng Lin, Chueh-Hung Wu, Tyng-Guey Wang, Sung-Chun Tang, Meng-Ting Lin
{"title":"Association of transcranial Doppler and carotid ultrasound parameters with swallowing outcomes after endovascular thrombectomy for anterior circulation stroke.","authors":"Hung-Hsi Lin, Shu-Mei Yang, Ting-Ju Lai, Yen-Heng Lin, Chueh-Hung Wu, Tyng-Guey Wang, Sung-Chun Tang, Meng-Ting Lin","doi":"10.1080/02699052.2026.2725666","DOIUrl":"https://doi.org/10.1080/02699052.2026.2725666","url":null,"abstract":"<p><strong>Background: </strong>Post-stroke dysphagia (PSD) remains prevalent after anterior circulation stroke treated with endovascular thrombectomy (EVT). We evaluated associations between ultrasound-derived hemodynamic indices and swallowing outcomes and their incremental prognostic value beyond clinical factors.</p><p><strong>Methods: </strong>This retrospective cohort included 169 adults with anterior circulation stroke treated with EVT between November 2018 and November 2023. Transcranial Doppler and carotid ultrasonography measured intracranial pulsatility index (PI) and extracranial resistive index (RI). Outcomes included nasogastric (NG) tube dependence and Functional Oral Intake Scale (FOIS) at 4 and 12 weeks.</p><p><strong>Results: </strong>Several RI and PI measures were associated with swallowing outcomes in univariable analyses. Basilar artery (BA) PI showed a weak correlation with time to NG tube removal (<i>r</i> = 0.160, <i>p</i> = 0.044). After adjustment for age, initial National Institutes of Health Stroke Scale (NIHSS), and 3-step swallowing screening, BA PI was not significantly associated with NG tube dependence at 4 weeks or 12 weeks (<i>p</i> = 0.134 and <i>p</i> = 0.064) and did not improve model discrimination (DeLong <i>p</i> = 0.281 and <i>p</i> = 0.362).</p><p><strong>Conclusions: </strong>Ultrasound-derived hemodynamic parameters were associated with swallowing outcomes after EVT, but the incremental prognostic value of BA PI beyond clinical factors was limited and requires prospective validation.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-9"},"PeriodicalIF":1.5,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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