{"title":"A longitudinal retrospective study on determinants of survival in chronic patients with severe acquired brain injuries and Disorders of Consciousness.","authors":"Camilla Ippoliti, Francesca Giulia Magnani, Arianna Fornari, Martina Cacciatore, Filippo Barbadoro, Cinzia Stellato, Matilde Leonardi","doi":"10.1080/02699052.2025.2558955","DOIUrl":"https://doi.org/10.1080/02699052.2025.2558955","url":null,"abstract":"<p><strong>Objective: </strong>To explore the survival time of adult chronic patients with Disorders of Consciousness (DOC).</p><p><strong>Methods: </strong>We retrospectively considered 244 chronic DOC patients in 14 long-term care (LTC) facilities from 2017 to 2020. We considered patients' demographics (age, sex) and clinical (etiology, Body Mass Index) variables to explore any difference in survival probabilities. For longitudinal descriptive purposes, time from acute events and total scores at different clinical scales addressing patients' level of consciousness and disability were also considered.</p><p><strong>Results: </strong>At the end of the 3-year follow-up period, 136 patients out of 244 died. The median overall survival was 67.6 months from the acute event, with significantly longer survival for younger patients and patients with traumatic etiology. However, almost all traumatic patients fall into the youngest patients' group.</p><p><strong>Conclusion: </strong>During LTC hospitalization, chronic DOC patients showed a high level of disability and their clinical profile remained stable unless comorbidities or clinical complications arose. Age at the acute event is the main factor explaining survival probability, while the role of etiology, an already-known relevant factor for prognosis in the acute and post-acute phases, might be secondary in the chronic phase.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-8"},"PeriodicalIF":1.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2025-09-18DOI: 10.1080/02699052.2025.2561795
Sarah Weström, Helena Hybbinette, Kajsa Gode, Jan Johansson
{"title":"The effect of colored overlays on reading in patients with acquired brain injury.","authors":"Sarah Weström, Helena Hybbinette, Kajsa Gode, Jan Johansson","doi":"10.1080/02699052.2025.2561795","DOIUrl":"https://doi.org/10.1080/02699052.2025.2561795","url":null,"abstract":"<p><strong>Objective: </strong>To investigate if colored overlays influences reading performance in adults with an acquired brain injury (ABI).</p><p><strong>Methods: </strong>An experimental cross-sectional study where patients with ABI and reading-related visual discomfort (<i>n</i> = 25) were recruited from an outpatient rehabilitation clinic. Reading speed with and without colored overlays was investigated using the Wilkins Rate of Reading Test (WRRT) and coherent text. Eye movements were recorded with the Readalyzer. The Visual Discomfort Scale (VDS) was used for symptom assessment.</p><p><strong>Results: </strong>Reading of WRRT was faster with an overlay (3.9%, <i>p</i> = 0.04). Participants with lower baseline reading speed (without overlay) showed greater improvements when reading the WRRT (median increase 10.9, 4.6-67.0%) and coherent text (median increase17.5, 5.5-93.2%). Improvements were reflected in significantly fewer progressive and regressive saccades, and shorter fixation durations. Improvements in reading speed correlated positively with VDS score (<i>p</i> = 0.05).</p><p><strong>Conclusions: </strong>The findings support the theory that colored overlays can facilitate reading in some patients. Possible mechanisms are discussed in relation to reading ability, visual, and cognitive functions. Further research will be needed to increase the understanding of sensory visual stress and the effect of colored overlays in the ABI population.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-9"},"PeriodicalIF":1.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2025-09-17DOI: 10.1080/02699052.2025.2559986
Reid A Syrydiuk, Chengyun Li, Allyssa K Memmini, Adrian J Boltz, Landon B Lempke, Jie Ren, Susan M Perkins, Jaroslaw Harezlak, Kelly M Mosesso, Paul F Pasquina, Thomas W McAllister, Michael A McCrea, Steven P Broglio
{"title":"The cumulative effects of a collegiate athletic career on general health measures: findings from the CARE Consortium.","authors":"Reid A Syrydiuk, Chengyun Li, Allyssa K Memmini, Adrian J Boltz, Landon B Lempke, Jie Ren, Susan M Perkins, Jaroslaw Harezlak, Kelly M Mosesso, Paul F Pasquina, Thomas W McAllister, Michael A McCrea, Steven P Broglio","doi":"10.1080/02699052.2025.2559986","DOIUrl":"https://doi.org/10.1080/02699052.2025.2559986","url":null,"abstract":"<p><strong>Objective: </strong>The acute effects of concussion and head impacts in collegiate student-athletes have been characterized, but not the effects at career end. We investigated how lifetime concussion history, sport contact exposure, and years of primary sport participation (YoP) associate with collegiate student-athlete health at institutional-exit.</p><p><strong>Methods: </strong>Collegiate student-athletes (<i>n</i> = 3,663) enrolled in the CARE Consortium cohort study completed eight assessments within 1 year of institutional-exit spanning physical/behavioral, mental and cognitive health, and neurobehavioral symptoms. Separate multivariable linear regressions assessed how sport contact exposure, concussion history (number), and YoP influence questionnaire scores, adjusting for sex, Race, and self-reported athlete-identity and resiliency scores.</p><p><strong>Results: </strong>Concussion history was associated with adverse scores within certain physical/behavioral, mental, and symptom health. Contact-exposed student-athletes reported improved scores on some cognitive, mental, and symptom health assessments. Greater YoP was associated with improved scores on two mental health questionnaires.</p><p><strong>Conclusions: </strong>Lifetime concussion history is associated with self-reported health outcomes at institutional-exit, though small effect sizes suggest limited clinical consequence. Higher contact-exposure sports and increased YoP were associated with improved scores on some clinical measures. Further longitudinal monitoring is encouraged to evaluate health-related changes over time, to support student-athletes as they transition out of collegiate sports.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-10"},"PeriodicalIF":1.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2025-09-10DOI: 10.1080/02699052.2025.2558954
Adam Mckay, Courtney Spiteri, Victoria Armao, Penny Analytis, James Stribling, Jennie Ponsford
{"title":"The experiences of nurses working with patients who are agitated following moderate-to-severe traumatic brain injury: a qualitative study.","authors":"Adam Mckay, Courtney Spiteri, Victoria Armao, Penny Analytis, James Stribling, Jennie Ponsford","doi":"10.1080/02699052.2025.2558954","DOIUrl":"https://doi.org/10.1080/02699052.2025.2558954","url":null,"abstract":"<p><strong>Background: </strong>Nurses are at the forefront of managing agitation after moderate-to-severe traumatic brain injury (msTBI), but little is known about their experiences. This study aimed to explore how nurses understand, experience, and manage agitation after msTBI in an inpatient rehabilitation setting.</p><p><strong>Methods: </strong>A qualitative descriptive study using semi-structured interviews was used to understand the experiences of agitation after msTBI for 15 nurses (aged 20-61 years, 80% female) on an inpatient brain injury rehabilitation unit. Reflexive thematic analysis was completed on interview transcripts.</p><p><strong>Results: </strong>Nursing experiences were characterized into four key themes relating to: 1) what nurses considered to be core features and causes of agitation; 2) factors they considered important in shaping agitation; 3) strategies they used to manage agitation; and 4) the challenges and rewards of working with patients at an early stage of recovery after TBI.</p><p><strong>Conclusions: </strong>Nurses had a detailed understanding of agitation after msTBI and its management. Managing agitation and PTA more broadly was experienced as physically, cognitively, and emotionally draining, yet it was seen as vital for supporting recovery and was personally meaningful for nurses. A lack of formal training and organizational support was a barrier to feeling competent and confident in the role.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-10"},"PeriodicalIF":1.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2025-09-01Epub Date: 2025-05-31DOI: 10.1080/02699052.2025.2513613
Yi-Hsuan Lin, Hsiao-Mei Chen, Bei-Yi Su
{"title":"Caregiving preparedness and depression as key predictors of quality of life in primary stroke caregivers: a cross-sectional study in Taiwan.","authors":"Yi-Hsuan Lin, Hsiao-Mei Chen, Bei-Yi Su","doi":"10.1080/02699052.2025.2513613","DOIUrl":"10.1080/02699052.2025.2513613","url":null,"abstract":"<p><strong>Purpose: </strong>This study examined how demographic factors, health status, and caregiving preparedness influence the quality of life (QoL) of primary caregivers of stroke patients in Taiwan.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted with 145 caregivers at a central Taiwan hospital. Data were collected using the Caregiving Preparedness Scale (PCS), an 8-item tool assessing readiness in general care, emergency management, and resource access (5-point Likert scale), and the WHOQOL-BREF Taiwan version, a 28-item measure of physical, psychological, social, and environmental QoL.</p><p><strong>Results: </strong>The average QoL score was 56.5 out of 80, assessed using WHOQOL-BREF. Stepwise regression analysis identified key predictors of QoL, with variance explained by CESD scores (34.9%), caregiving preparedness (19.3%), caregiver age (8.3%), marital status (0.9%), caregiving time (0.8%), employment status (0.7%), patient age (1.2%), and IADL score (2.6%). The reported percentages reflect each factor's contribution to QoL variance.</p><p><strong>Conclusions: </strong>Support should be prioritized for caregivers with high depression scores, low caregiving preparedness, and socioeconomic vulnerabilities such as unemployment or low household income, to enhance their quality of life. The reported percentages reflect the variance in QoL explained by each predictor in the regression analysis.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1024-1033"},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2025-09-01Epub Date: 2025-05-29DOI: 10.1080/02699052.2025.2512785
Eujene Jung, Jung-Ho Lee, Hyeng-Kyu Park
{"title":"Association between serum magnesium level and long-term prognosis of traumatic brain injury.","authors":"Eujene Jung, Jung-Ho Lee, Hyeng-Kyu Park","doi":"10.1080/02699052.2025.2512785","DOIUrl":"10.1080/02699052.2025.2512785","url":null,"abstract":"<p><strong>Purpose: </strong>Our study aimed to investigate the association between initial serum magnesium levels and long-term functional outcomes in patients with TBI, accounting for variations across different age groups.</p><p><strong>Methods: </strong>This retrospective study included adult patients with TBI and intracranial injury treated at a level-1 trauma hospital. The primary exposure was on serum magnesium levels within 6 hour of emergency department admission. Study outcomes included 6-month mortality and disability, assessed using the Glasgow Outcome Scale (scores 1-3). Multilevel multivariable logistic regression analysis was conducted to determine the relationship between serum magnesium levels and study outcomes, with stratified analysis employed to investigate potential variations based on age groups.</p><p><strong>Results: </strong>Low magnesium levels were significantly associated with an increased risk of 6-month disability (Odds ratio (OR) 1.80, 95% confidence interval (CI): 1.14-2.68) and 6-month mortality (OR: 1.82, 95% CI: 1.03-2.99). This association remained significant exclusively among younger patients, with ORs of 2.70 (95% CI: 1.21-5.14) for 6-month disability and 2.33 (95%, CI: 1.11-4.49) for 6-month mortality when stratified by age.</p><p><strong>Conclusion: </strong>Low serum magnesium levels are associated with poorer long-term outcomes in patients with TBI, and this effect is especially pronounced in younger adults (18-64 years). Specifically, younger patients exhibiting hypomagnesemia demonstrated a higher incidence of 6-month disability and mortality. These findings suggest a need to identify the causative links and explore whether correcting serum magnesium levels will improve TBI prognosis across different age groups.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1016-1023"},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2025-09-01Epub Date: 2025-07-01DOI: 10.1080/02699052.2025.2525102
Nick De Oliveira, Jai Horsey, Jordan Vanleuven, Kristen L Williams, Scott L Zuckerman, Douglas P Terry
{"title":"Does the presence of acute sleep initiation symptoms impact recovery from sport-related concussion?","authors":"Nick De Oliveira, Jai Horsey, Jordan Vanleuven, Kristen L Williams, Scott L Zuckerman, Douglas P Terry","doi":"10.1080/02699052.2025.2525102","DOIUrl":"10.1080/02699052.2025.2525102","url":null,"abstract":"<p><strong>Objective: </strong>Acute sleep disturbances after sport-related concussions (SRC) may affect recovery. This study assessed how sleep symptoms impact time to return-to-learn (RTL), symptom resolution (SR), and return-to-play (RTP).</p><p><strong>Methods: </strong>A retrospective cohort study was conducted at a regional sports concussion center (11/2017-04/2022) with adolescents presenting within 3 days of SRC. Participants were dichotomized based on the presence or absence of 'trouble falling asleep' per the Post-Concussion Symptom Scale (PCSS). Mann-Whitney U tests compared outcomes, and multivariable regressions adjusted for PCSS, sex, age, and migraine or psychological history.</p><p><strong>Results: </strong>Among 116 athletes, 29 (25%) reported sleep initiation symptoms. Median RTL was 4 days (IQR = 3-10) in those with sleep symptoms versus 3 days (IQR = 2-4, <i>p</i> = 0.005) without. Median SR and RTP times were longer for the sleep initiation symptoms group: 15 days (IQR = 7-27) vs. 8 days (IQR = 3-20, <i>p</i> = 0.024) for SR, and 16 days (IQR = 11-29) vs. 13 days (IQR = 6-21, <i>p</i> = 0.048) for RTP. Sleep initiation symptoms were not independent predictors of recovery, but migraine history predicted longer RTL, and prior concussions predicted longer RTP.</p><p><strong>Conclusions: </strong>Although not independent predictors, acute sleep initiation symptoms were linked to delayed recovery. Strategies to optimize sleep acutely post-concussion may help facilitate timely recovery and improve outcomes.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1052-1061"},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Psychiatric outcomes and quality of life in adolescents with moderate traumatic brain injury: a 6-month follow-up study.","authors":"Yekta Özkan, Masum Öztürk, Bülent Azman, Ismail Bozkurt","doi":"10.1080/02699052.2025.2549938","DOIUrl":"10.1080/02699052.2025.2549938","url":null,"abstract":"<p><strong>Introduction: </strong>There is limited evidence regarding the association between traumatic brain injury (TBI) and the emergence of new-onset psychiatric disorders in adolescents. This prospective study analysed psychiatric disorders, quality of life, and emotional and behavioral difficulties in adolescents with TBI and orthopedic trauma at a 6-month follow-up.</p><p><strong>Methods: </strong>Adolescents with TBI and a control orthopedic trauma group (without a history of psychiatric disorders) were evaluated using both the Strengths and Difficulties Questionnaire and the Paediatric Quality of Life Inventory.</p><p><strong>Results: </strong>Forty-one adolescents with TBI and 45 with orthopedic injuries were assessed. TBI patients had significantly lower quality of life and higher levels of emotional difficulties. The prevalence of psychiatric disorders was higher in the TBI group (41.5% vs 15.6%). TBI group had higher rates of post-traumatic stress disorder and depression after 6 months. Hospitalization length and GCS scores were correlated with quality of life outcomes. Regression analysis revealed the presence of psychiatric disorders at 6 months was a significant predictor of reduced quality of life.</p><p><strong>Conclusion: </strong>This study highlights a significant association between TBI and poorer quality of life and mental health outcomes in adolescents. Adolescents with TBI had higher rates of psychiatric disorder, more pronounced emotional difficulties, and a lower quality of life.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1062-1075"},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}