Brain injuryPub Date : 2025-05-06DOI: 10.1080/02699052.2025.2499488
Mark Pedrotty, Emily C Grossner, Elisabeth A Wilde, Madison M Mackenzie, Tiffanie S Wong
{"title":"Applying the ICRP model to writing recommendations in a neuropsychological evaluation for brain injury populations.","authors":"Mark Pedrotty, Emily C Grossner, Elisabeth A Wilde, Madison M Mackenzie, Tiffanie S Wong","doi":"10.1080/02699052.2025.2499488","DOIUrl":"https://doi.org/10.1080/02699052.2025.2499488","url":null,"abstract":"<p><strong>Objective: </strong>This manuscript aims to describe how to use the Integrative Cognitive Rehabilitation Psychotherapy (ICRP) model to formulate neuropsychological recommendations following brain injury that are comprehensive, individually tailored, empirically based, and culturally appropriate.</p><p><strong>Background: </strong>The ICRP model utilizes a developmental metacognitive approach to increase self awareness after brain injury by first addressing basic cognitive abilities before focusing on higher-level cognitive domains. Detailed within this model are assessments of stages of recovery (e.g. surviving, healing, thriving, and maintaining) and readiness to change (e.g. precontemplation, contemplation, preparation, action, and maintenance) to help determine appropriate recommendations and interventions for management of brain injury sequelae and concomitant issues.</p><p><strong>Conclusion: </strong>This unique approach to creating recommendations and treatment plans for brain injury recovery may be more time intensive than a traditional outpatient neuropsychological evaluation, but includes the added benefit of collaborating with the patient, family/caregivers, and treatment team to maximize rehabilitation success and improve quality of life.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-12"},"PeriodicalIF":1.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2025-05-05DOI: 10.1080/02699052.2025.2490285
Vibeke Wagner, Jakob Rud Sørensen, Christina Kruuse, Ingrid Poulsen, Fin Biering-Sørensen, Christian Gunge Riberholt
{"title":"Robot-assisted gait training for individuals with severe acquired brain injury: a scoping review.","authors":"Vibeke Wagner, Jakob Rud Sørensen, Christina Kruuse, Ingrid Poulsen, Fin Biering-Sørensen, Christian Gunge Riberholt","doi":"10.1080/02699052.2025.2490285","DOIUrl":"https://doi.org/10.1080/02699052.2025.2490285","url":null,"abstract":"<p><strong>Introduction: </strong>Early out-of-bed mobilization is recommended for individuals with severe acquired brain injury and impaired consciousness to promote recovery. Robot-assisted gait training (RAGT) utilizes robotic assistance to facilitate neuroplastic changes through repetitive training and feedback. We aimed to map the evidence of RAGT in non-ambulatory individuals with impaired consciousness or cognitive functioning, focusing on the rationales underpinning its use and the assessment methods employed.</p><p><strong>Method: </strong>Following the Joanna Briggs Institute and PRISMA scoping review guidelines, we systematically searched for studies involving adults with severe acquired brain injury. Source selection, data extraction, and charting were performed in duplicate.</p><p><strong>Results: </strong>Out of 10 444 records screened, seven were included, involving 162 participants. The studies included one randomized and two non-randomized clinical trials, two retrospective studies, and two case reports. RAGT aimed to improve physical recovery (<i>n</i> = 6), arousal stimulation (<i>n</i> = 4), and safety (<i>n</i> = 4). Twenty-six outcome measures were reported.</p><p><strong>Conclusion: </strong>Our review highlights a research gap in RAGT for individuals with severe brain injury and cognitive impairments. Specifically, the underlying rationales need investigation, and standardized outcome measures must be established. RAGT shows potential in improving functional recovery and consciousness, but future studies must address safety, and feasibility while navigating ethical challenges.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-11"},"PeriodicalIF":1.5,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2025-05-05DOI: 10.1080/02699052.2025.2492752
Gilad Sorek, Arianne Racine, Miriam H Beauchamp, Isabelle Gagnon
{"title":"Is injury-related parental stress in the acute phase following early childhood concussion associated with symptoms and recovery?","authors":"Gilad Sorek, Arianne Racine, Miriam H Beauchamp, Isabelle Gagnon","doi":"10.1080/02699052.2025.2492752","DOIUrl":"https://doi.org/10.1080/02699052.2025.2492752","url":null,"abstract":"<p><strong>Objective: </strong>To examine the association between injury-related parental-stress during the acute phase following early-childhood concussion on post-concussion-symptoms (PCS) severity and recovery.</p><p><strong>Methods: </strong>Thirty-eight children aged 0.1-5.7 years (median 1.3) following concussion, within 72-h post-injury, were included. Injury-related parental-stress was screened using three questions from the Revised-Illness-Perception questionnaire, regarding the child's 1) well-being, 2) injury-outcomes, and 3) recovery. PCS were assessed using the Post-Concussion-Symptoms-Inventory-Parent form (PCSI-P). Since not all symptoms were suitable for all ages, individualized percentage scores for both the PCSI-P number-of-symptoms (number-PCSI-P) and PCSI-P symptom-severity (severity-PCSI-P) were calculated. Parents completed the stress questionnaire and PCSI-P in the emergency-department (T0), and two-weeks post-injury (T1). The PCSI-P was also completed 1-month post-injury (T2).</p><p><strong>Results: </strong>Parental-stress did not change significantly between T0 and T1. However, the number and severity of PCSI-P significantly decreased over this period (<i>p</i> < 0.001). A significant moderate positive correlation was found between T0 and T1 parental-stress and T0 number-PCSI-P (r<sub>s</sub> = 0.39;<i>p</i> = 0.015 and r<sub>s</sub> = 0.49;<i>p</i> = 0.002, respectively) and severity-PCSI-P (r<sub>s</sub> = 0.42;<i>p</i> = 0.008 and r<sub>s</sub> = 0.58;<i>p</i> < 0.001, respectively). At T2, 26 children were fully recovered; they presented lower T0 PCSI-P scores (<i>p</i> < 0.049), but showed no difference in parental-stress scores.</p><p><strong>Conclusion: </strong>Higher injury-related parental-stress following early childhood concussion is associated with PCS in the first 72-h post-injury, but not with symptom recovery.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-5"},"PeriodicalIF":1.5,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2025-04-21DOI: 10.1080/02699052.2025.2493352
V P Lakshmi Priya, M Devi
{"title":"Potential of integrating phytochemicals with standard treatments for enhanced outcomes in TBI.","authors":"V P Lakshmi Priya, M Devi","doi":"10.1080/02699052.2025.2493352","DOIUrl":"https://doi.org/10.1080/02699052.2025.2493352","url":null,"abstract":"<p><strong>Objective: </strong>TBI's intricate pathophysiology, which includes oxidative stress, neuroinflammation, apoptosis, and mechanical injury, makes it a serious public health concern. Although stabilization and secondary damage management are the main goals of current treatments, their efficacy is still restricted. The potential for improving patient outcomes by combining phytochemicals with traditional medicines is examined in this review.</p><p><strong>Methods: </strong>The study examined the neuroprotective qualities of ginsenosides, ginkgolides, resveratrol, and curcumin as well as their antioxidant and anti-inflammatory activities. Analysis was done on molecular pathways and medication delivery techniques to improve translational outcomes and drug availability for clinical practice.</p><p><strong>Results: </strong>Phytochemical substances directly influence TBI-related neurogenic pathways and functional restoration while also affecting subsequent neural damage processes. Particle-based medicine delivery platforms enhance therapeutic drug efficacy, emerging as innovative solutions for targeted drug delivery. When traditional medical therapies integrate with phytochemicals, it becomes possible to achieve better patient results through enhanced synergy.</p><p><strong>Conclusion: </strong>This review uniquely integrates phytochemicals with standard TBI treatments, emphasizing advanced drug delivery strategies and their translational potential to enhance neuroprotection and clinical outcomes. Unlike previous studies, it explores novel drug delivery platforms, such as nanoparticle-based systems, and highlights the synergy between phytochemicals and conventional therapies to improve patient recovery.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-17"},"PeriodicalIF":1.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2025-04-21DOI: 10.1080/02699052.2025.2492746
Keith L Main, Andrei A Vakhtin, Jiachen Zhuo, Donald Marion, Maheen M Adamson, J Wesson Ashford, Rao Gullapalli, Ansgar J Furst
{"title":"An iterative ROC procedure identifies white matter tracts diagnostic for traumatic brain injury: an exploratory analysis in U.S. Veterans.","authors":"Keith L Main, Andrei A Vakhtin, Jiachen Zhuo, Donald Marion, Maheen M Adamson, J Wesson Ashford, Rao Gullapalli, Ansgar J Furst","doi":"10.1080/02699052.2025.2492746","DOIUrl":"https://doi.org/10.1080/02699052.2025.2492746","url":null,"abstract":"<p><strong>Objective: </strong>Understanding the pathophysiology of traumatic brain injury (TBI) is crucial for effectively managing care. Diffusion tensor imaging (DTI) is an MRI technology that evaluates TBI pathology in brain white matter. However, DTI analysis generates numerous measures. Choosing between them remains an obstacle to clinical translation. In this study, we leveraged an iterative receiver operating characteristic (ROC) analysis to examine white matter tracts in a group of 380 Veterans, consisting of TBI (<i>n</i> = 243) and non-TBI patients (<i>n</i> = 137).</p><p><strong>Method: </strong>For each participant, we obtained a whole brain tractography and extracted DTI measures from 50 tracts. The ROC analyzed these variables and produced decision trees of tracts diagnostic for TBI. We expanded our findings by applying jackknife resampling. This procedure removed potential outliers and yielded tracts not observed in the initial ROCs. Finally, we used logistic regression to confirm the tracts predicted TBI status.</p><p><strong>Results: </strong>Our results indicate ROC can identify tracts diagnostic for TBI. We also found that groups of tracts are more predictive than any single one.</p><p><strong>Conclusions: </strong>These analyses show that ROC is a useful tool for exploring large, multivariate datasets and may inform the design of clinical algorithms.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-19"},"PeriodicalIF":1.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2025-04-21DOI: 10.1080/02699052.2025.2489599
Jeffrey S Garofano, Claire H Pak
{"title":"Traumatic brain injury in adolescents: the relationship between high school exiting status and future productivity.","authors":"Jeffrey S Garofano, Claire H Pak","doi":"10.1080/02699052.2025.2489599","DOIUrl":"https://doi.org/10.1080/02699052.2025.2489599","url":null,"abstract":"<p><strong>Objective: </strong>Investigate the relationship between high school exiting type and productivity in post-secondary education and employment among students who suffered a moderate-to-severe traumatic brain injury (TBI) while in high school.</p><p><strong>Methods: </strong>This retrospective cohort study included 225 16-18-year-old students who attended neurorehabilitation after a moderate-to-severe TBI. All injuries occurred while attending high school; all youth attended neurorehabilitation at a TBI Model Systems Hospital. We measured productivity as mean weekly hours in post-secondary education and employment 5 years post-injury. We examined the unique contribution of high school exiting type to long-term productivity with hierarchical linear regressions, controlling for patient demographics, pre-injury factors, and injury/disability severity.</p><p><strong>Results: </strong>Most participants (82%) graduated high school with a diploma. Graduates reported more weekly productivity hours (23.61) than those who exited with a General Educational Development (GED) (12.85) or non-completers (5.97). All control variables contributed significantly to 5-year productivity and a diploma or GED was uniquely related to productivity.</p><p><strong>Conclusions: </strong>Graduating high school is attainable for most youth who experience a TBI during high school. Graduating with a diploma or GED was uniquely related to 5-year productivity, providing a clear incentive for collaboration between neurorehabilitation services and schools.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-7"},"PeriodicalIF":1.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2025-04-20DOI: 10.1080/02699052.2025.2493354
Alexandra E Rose, Breda Cullen, Sarah Crawford, Jonathan J Evans
{"title":"The assessment of mood in people with severe cognitive and communication impairments following brain injury: a survey of UK-based professionals.","authors":"Alexandra E Rose, Breda Cullen, Sarah Crawford, Jonathan J Evans","doi":"10.1080/02699052.2025.2493354","DOIUrl":"https://doi.org/10.1080/02699052.2025.2493354","url":null,"abstract":"<p><strong>Aim: </strong>Assessing mood via standardized measures and clinical interviews is challenging in people with ongoing cognitive and receptive communication impairments after a severe brain injury. This study examined how healthcare professionals in the United Kingdom assess this population via two online surveys, one of clinical psychologists (CPs) and one of medical professionals (MPs).</p><p><strong>Method: </strong>Recruitment was completed via social media and invitational e-mails to identified services, professional bodies and special interest groups. Survey responses were via multiple choice and free text. Responses were analyzed using descriptive statistics and content analysis.</p><p><strong>Results: </strong>55 CPs and 29 MPs responded. All respondents reported asking others about the patient's mood, and the majority of both groups interview and observe the patient. 86% of CPs and 45% of MPs use standardized measures. Most of the CPs made adaptations to the measures, as did more than a third of MPs. The majority of both groups made adaptations to the scores.</p><p><strong>Conclusions: </strong>Most clinicians assessing mood in this population ask others about the person. Mood measures are used, but the administration and score interpretation are frequently adapted, bringing the validity of the use of measures in this population into question. Although there was overlap regarding methods used by surveyed clinicians, there was no clear consensus on how mood should be assessed in this population.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-16"},"PeriodicalIF":1.5,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2025-04-18DOI: 10.1080/02699052.2025.2493785
Pei-Hao Chen, Hsin-Hui Wang, Yi-Hsuan Tang, Chien-Hung Lin, Wei-Sheng Lin
{"title":"Ictal-interictal spectrum: an EEG warning sign of hypertensive encephalopathy.","authors":"Pei-Hao Chen, Hsin-Hui Wang, Yi-Hsuan Tang, Chien-Hung Lin, Wei-Sheng Lin","doi":"10.1080/02699052.2025.2493785","DOIUrl":"https://doi.org/10.1080/02699052.2025.2493785","url":null,"abstract":"<p><strong>Objective: </strong>Hypertensive encephalopathy may complicate the course of pediatric nephrotic syndrome, and the resulting brain injury is not always reversible. Subclinical electroencephalographic activities may play a role in this context, as demonstrated by the case vignette.</p><p><strong>Method: </strong>We report on a girl with IgA nephropathy and secondary hypertension, leading to posterior reversible encephalopathy syndrome (PRES). The correlated neuroimaging and electroencephalographic findings are examined, and their clinical implications are discussed.</p><p><strong>Results: </strong>PRES could be associated with lateralized periodic discharges on electroencephalogram, which was topographically concordant with neuroimaging findings in this patient. Despite being clinically silent, the lateralized periodic discharges may potentially increase cerebral metabolic demand and adversely impact the neurological outcomes.</p><p><strong>Conclusion: </strong>Electroencephalographic monitoring should be considered in the context of PRES, as it may help detect subclinical electrical activities in the brain, which is of potential therapeutic relevance.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-3"},"PeriodicalIF":1.5,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}