Brain injury最新文献_第2页

Medical complications and advance medical decision-making in the minimally conscious state. 微意识状态下的医疗并发症和预先医疗决策。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-21 Epub Date: 2024-11-12 DOI: 10.1080/02699052.2024.2425737

Berno U H Overbeek, Willemijn S van Erp, Henk J Eilander, Raymond T C M Koopmans, Jan C M Lavrijsen

{"title":"Medical complications and advance medical decision-making in the minimally conscious state.","authors":"Berno U H Overbeek, Willemijn S van Erp, Henk J Eilander, Raymond T C M Koopmans, Jan C M Lavrijsen","doi":"10.1080/02699052.2024.2425737","DOIUrl":"10.1080/02699052.2024.2425737","url":null,"abstract":"Objectives: Medical complications occur frequently in MCS and influence advance medical decision-making. This study aimed to report on medical complications and advance medical decision-making in a nationwide group of MCS patients.Methods: In this descriptive cross-sectional study, clinical and advance medical decision-making characteristics were collected in a survey, completed by the treating physician.Results: The MCS population consisted of 32 patients: 65.6% traumatic etiology, 68.8% male. Patients had a median of five complications: hypertonia/spasticity (81.3%) and pneumonia (50.0%) occurred most frequently. Most patients had curative goals: three patients had a fully curative treatment scenarios, 29 a curative scenario with ≥ 1 treatment restrictions, two a palliative and two a symptomatic scenario. Conversations about advance medical decision-making were complicated by disputes with next of kin, inability to evaluate medical treatment because of medical instability, next of kin not being ready to discuss medical treatment, or a treatment scenario explicitly based on requests of next of kin.Conclusion: Medical complications are common in MCS patients and advance medical decision making was complicated. This legitimates realization of specialized care across acute, post-acute and long-term care. Further longitudinal research into advance medical decision-making is recommended.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"249-256"},"PeriodicalIF":1.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding 'quality' in adult traumatic brain injury rehabilitation from the perspectives of different stakeholders: a participatory mixed methods study. 从不同利益相关者的角度理解成人脑外伤康复的 "质量"：一项参与式混合方法研究。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-21 Epub Date: 2024-11-16 DOI: 10.1080/02699052.2024.2425743

Carolyn Murray, Anthea Worley, Julie Luker, Susan Hillier

{"title":"Understanding 'quality' in adult traumatic brain injury rehabilitation from the perspectives of different stakeholders: a participatory mixed methods study.","authors":"Carolyn Murray, Anthea Worley, Julie Luker, Susan Hillier","doi":"10.1080/02699052.2024.2425743","DOIUrl":"10.1080/02699052.2024.2425743","url":null,"abstract":"Primary objective: The purpose of this study was to explore how 'quality' is understood for traumatic brain injury (TBI) rehabilitation from the perspectives of the rehabilitation recipients, their families and the providing clinicians.Research design: A participatory study using a mixed-methods, triangulation design.Methods: The study involved 1. a systematic literature search; 2. Individual semi-structured interviews with people with TBI and/or their caregivers and TBI rehabilitation clinicians, and 3. an online consensus process.Outcomes and results: 22 participants (7 people with TBI, 8 caregivers, 7 clinicians) participated in individual interviews. Their transcribed data were coded into broad categories via in-depth reflexive, thematic analysis; these categories were then mapped to 13 quality domains extracted from the literature. The emergent themes were then presented to the individuals, via an electronic consensus tool in two rounds. This resulted in 12 prioritized domains of quality that encompass service features, staff qualities and effectiveness.Conclusion: These evidence-informed and consensus-agreed indicators for quality may help guide both the provision and evaluation of TBI rehabilitation, that is valued and meaningful.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"257-266"},"PeriodicalIF":1.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Responding to the ongoing pandemic-related challenges of individuals with brain injury through the perspective of community-service in Canada: A qualitative study. 通过加拿大社区服务的视角应对脑损伤患者当前面临的与大流行病相关的挑战：定性研究。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-21 Epub Date: 2024-11-16 DOI: 10.1080/02699052.2024.2426683

Ana Paula Salazar, Sophie Lecours, Lisa Engel, Monique A M Gignac, Shlomit Rotenberg, Sareh Zarshenas, Michelle McDonald, Emily Nalder, Carolina Bottari

{"title":"Responding to the ongoing pandemic-related challenges of individuals with brain injury through the perspective of community-service in Canada: A qualitative study.","authors":"Ana Paula Salazar, Sophie Lecours, Lisa Engel, Monique A M Gignac, Shlomit Rotenberg, Sareh Zarshenas, Michelle McDonald, Emily Nalder, Carolina Bottari","doi":"10.1080/02699052.2024.2426683","DOIUrl":"10.1080/02699052.2024.2426683","url":null,"abstract":"Objective: To investigate brain injury (BI) associations' perspectives regarding the impacts of the second year of the COVID-19 pandemic on individuals with BI and BI associations services across Canada.Methods: This qualitative descriptive study included 26 representatives of Canadian BI associations that participated in six online focus groups to discuss the effects of the second year of the pandemic on clients living with BI and on the provision of community services.Results: Findings revealed three main themes: 1) ongoing pandemic-related challenges faced by clients living with BI, including worsening mental health and basic needs insecurities, difficulties faced by clients in adhering to safety measures, and ongoing technological issues; 2) ongoing adaptations to accommodate clients' needs, including offering tailored services, ensuring consistent and transparent safety measures, and providing hybrid services; and 3) developing a sustainable 'new normal' aligned with association mandates and resources by expanding networks and building resilience.Conclusion: The unfolding of the pandemic has brought increased challenges for people with BI and reinforced the need for adapted, clear, and accessible public health information to ensure the safety of vulnerable populations in times of crisis. It is essential to bolster community-based associations that provide direct care to people with BI.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"267-276"},"PeriodicalIF":1.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of influencing factors for postoperative brain injury in patients with cardiac surgery. 心脏手术患者术后脑损伤影响因素分析。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-21 Epub Date: 2024-12-06 DOI: 10.1080/02699052.2024.2430386

Weifang Xu, Xiaolan Ma, Chen Zhang

{"title":"Analysis of influencing factors for postoperative brain injury in patients with cardiac surgery.","authors":"Weifang Xu, Xiaolan Ma, Chen Zhang","doi":"10.1080/02699052.2024.2430386","DOIUrl":"10.1080/02699052.2024.2430386","url":null,"abstract":"Objective: To identify risk factors in people with heart disease prior to undergoing cardiac surgery and to provide a prediction model.Methods: 106 patients who underwent cardiac surgery were selected by convenience sampling method. Case-control study design was used to divide them into control and observation groups according to whether there was postoperative brain injury. General demographic data, perioperative surgery, postoperative recovery, past medical history and preoperative conditions, laboratory test indicators were collected. Univariate and multivariate Logistic regression analyses were performed to select influencing factors. A nomogram model for predicting postoperative brain injury was established.Results: Univariate Logistic regression analysis showed that age, female, stroke, diabetes mellitus, perioperative administration of dexmedetomidine, intraoperative use of cardiopulmonary bypass were related factors for postoperative brain injury(p < 0.05). Multivariate Logistic regression analysis showed that females, history of stroke, and intraoperative use of cardiopulmonary bypass were risk factors, and perioperative administration of dexmedetomidine was protective factor(p < 0.05). Nomogram model was established with an AUC of 0.847 and accuracy of 84.7%.Conclusion: Preoperative stroke history and females are risk factors for brain injury after coronary artery bypass grafting under cardiopulmonary bypass, and perioperative use of dexmedetomidine is protective factor.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"320-329"},"PeriodicalIF":1.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cross-season analysis of S100B as a potential marker of concussion in professional rugby players. S100B作为职业橄榄球运动员脑震荡潜在标志的跨赛季分析。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-21 Epub Date: 2024-12-02 DOI: 10.1080/02699052.2024.2429700

Áine M Kelly, Clíodhna McHugh, James Hale, Joice Cunningham, Noreen Boyle, Oisín Joyce, Brendan O'Connell, Gareth Farrell, Fiona Wilson

{"title":"A cross-season analysis of S100B as a potential marker of concussion in professional rugby players.","authors":"Áine M Kelly, Clíodhna McHugh, James Hale, Joice Cunningham, Noreen Boyle, Oisín Joyce, Brendan O'Connell, Gareth Farrell, Fiona Wilson","doi":"10.1080/02699052.2024.2429700","DOIUrl":"10.1080/02699052.2024.2429700","url":null,"abstract":"Objectives: To investigate the effect of multiple seasons of play on serum S100B concentration in male professional rugby players, while also assessing the acute effects following a season of play and concussion.Methods: A prospective study of professional male rugby players over three seasons (2016/17 to 2018/19) was conducted. Serum sampling was carried out during pre-season, post-season and following a concussion; sustained during match play at a home game (between 2-24hrs), during each season. Serum S100B concentrations were determined by ELISA assay.Results: Fourteen players sustained 24 concussions over three seasons, of which 13 samples (54%) were collected. Pre- and post-season serum S100B remained stable across multiple seasons. S100B concentration increased significantly following concussion compared with pre-season (p = 0.002) and post-season (p = 0.009), reflective in a 3.23-fold-change post-concussion, with no difference found between pre- and post-season values. S100B concentration measured at post-season was not significantly different for players who had a concussion during a season and players who did not.Conclusion: S100B remains stable across multiple seasons of play in professional rugby players. As concussion results in a temporary increase in S100B concentration, returning to pre-season values by post-season, S100B may be a useful diagnostic marker for improving existing management protocols for sports-related concussions.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"312-319"},"PeriodicalIF":1.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dodecafluoropentane improves neuro-behavioral outcomes and return of spontaneous circulation rate in a swine model of cardiac arrest. 十二氟戊烷可改善猪心脏骤停模型的神经行为结果和自发性循环恢复率。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-21 Epub Date: 2024-11-21 DOI: 10.1080/02699052.2024.2427803

Travis W Murphy, Robert J Cueto, Jiepei Zhu, Jacob Milling, Justin Sauter, Muna Oli, Ian T Griffin, Gagan Midathala, J Adrian Tyndall, Bruce Spiess, Kevin K W Wang, Firas H Kobeissy, Torben K Becker

{"title":"Dodecafluoropentane improves neuro-behavioral outcomes and return of spontaneous circulation rate in a swine model of cardiac arrest.","authors":"Travis W Murphy, Robert J Cueto, Jiepei Zhu, Jacob Milling, Justin Sauter, Muna Oli, Ian T Griffin, Gagan Midathala, J Adrian Tyndall, Bruce Spiess, Kevin K W Wang, Firas H Kobeissy, Torben K Becker","doi":"10.1080/02699052.2024.2427803","DOIUrl":"10.1080/02699052.2024.2427803","url":null,"abstract":"Introduction: Dodecafluoropentane emulsion (DDFPe) administration has previously demonstrated improved gas exchange in single-organ perfusion models. This could translate to prevention of brain injury in cardiac arrest.Methods: We induced cardiac arrest in 12 pigs, performing CPR after 5-minute downtime. Pigs were randomly assigned to DDFPe (n = 7) or saline placebo (n = 5) groups. Neurologic injury biomarkers were measured at baseline, after return of spontaneous circulation (ROSC), and every 24 hours in survivors. Blinded Neurological Alertness Score, Neurological Dysfunction Score, and Overall Performance Score was performed in addition to histopathological scoring of parietal and hippocampal sections.Results: One placebo and four DDFPe pigs survived the 96-hour observation period. The odds ratio for ROSC was 7.2 (p = 0.22). Survival odds ratio was 4.6 (p = 0.29). All surviving animals had impaired motor responses that recovered by 72 hours. DDFPe animals showed better neuro-behavioral scores than placebo.Conclusion: The findings of this novel study provide a proof of concept and early signal toward efficacy of intravenous DDFPe in cardiac arrest. The trend toward improved ROSC and functional survival may reflect improved microcirculatory gas exchange in DDFPe animals. Improving gas exchange in brain microcirculation during resuscitation from cardiac arrest may provide a significant therapeutic benefit.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"277-285"},"PeriodicalIF":1.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality of life after brain injury in children and adolescents questionnaire - validation of the proxy version (QOLIBRI-KID/ADO-Proxy).

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-21 DOI: 10.1080/02699052.2025.2481435

Nicole von Steinbuechel, Marina Zeldovich, Ivana Holloway, Anna C Mayer, Philine Rojczyk, Ugne Krenz, Inga K Koerte, Michaela Veronika Bonfert, Steffen Berweck, Matthias Kieslich, Knut Brockmann, Maike Roediger, Michael Lendt, Michael Staebler, Christian Auer, Axel Neu, Alexander Kaiser, Joenna Driemeyer, Ulrike Wartemann, Daniel Pinggera, Claudius Thomé, Victoria Schoen, Philipp Geiger, Joachim Suss, Anna Buchheim, Holger Muehlan, Katrin Cunitz

{"title":"Quality of life after brain injury in children and adolescents questionnaire - validation of the proxy version (QOLIBRI-KID/ADO-Proxy).","authors":"Nicole von Steinbuechel, Marina Zeldovich, Ivana Holloway, Anna C Mayer, Philine Rojczyk, Ugne Krenz, Inga K Koerte, Michaela Veronika Bonfert, Steffen Berweck, Matthias Kieslich, Knut Brockmann, Maike Roediger, Michael Lendt, Michael Staebler, Christian Auer, Axel Neu, Alexander Kaiser, Joenna Driemeyer, Ulrike Wartemann, Daniel Pinggera, Claudius Thomé, Victoria Schoen, Philipp Geiger, Joachim Suss, Anna Buchheim, Holger Muehlan, Katrin Cunitz","doi":"10.1080/02699052.2025.2481435","DOIUrl":"https://doi.org/10.1080/02699052.2025.2481435","url":null,"abstract":"Background: The QOLIBRI-KID/ADO-Proxy is the first disease-specific health-related quality of life (HRQoL) proxy questionnaire developed for use in the field of pediatric traumatic brain injury (TBI), when children are unable to report their HRQoL themselves.Methods: Its psychometric properties in a German-speaking context are examined in two samples (development and validation). Dyads of 600 parents and their children (aged 8-17 years) were included.Results: The 35-item questionnaire covers six dimensions (Cognition, Self, Daily Life and Autonomy, Social Relationships, Emotions, and Physical Problems). Results showed good to excellent internal consistencies, acceptable test-retest reliability, and low to fair parent-child agreement. Confirmatory factor analyses supported the one-level six-factor structure. In terms of construct validity, there was an overlap between the disease-specific and the generic HRQoL. Lower parent-reported HRQoL in children was associated with lower parental education, lower functional recovery (Study I), more recent TBI, and more severe depressive, anxiety, and post-concussion symptoms. Findings differed between the two studies in terms of age, gender, and TBI severity. Study I found more severe TBI linked to lower HRQoL in adolescents, while Study II indicated lower HRQoL ratings in girls.Conclusion: The QOLIBRI-KID/ADO-Proxy is recommended when individuals are unable to self-report their HRQoL.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-16"},"PeriodicalIF":1.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding factors influencing exercise program adherence for youth with persistent post-concussive symptoms (PPCS). 了解影响有持续性脑震荡后症状（PPCS）的青少年坚持运动计划的因素。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-21 Epub Date: 2024-11-19 DOI: 10.1080/02699052.2024.2428404

Beth J Bollinger, Sara Pd Chrisman, Jordan Sahlberg, Jason A Mendoza, Tonya M Palermo, Chuan Zhou, M Alison Brooks, Frederick P Rivara, Payton Pedersen, Emily Prentice, Colby Hansen

{"title":"Understanding factors influencing exercise program adherence for youth with persistent post-concussive symptoms (PPCS).","authors":"Beth J Bollinger, Sara Pd Chrisman, Jordan Sahlberg, Jason A Mendoza, Tonya M Palermo, Chuan Zhou, M Alison Brooks, Frederick P Rivara, Payton Pedersen, Emily Prentice, Colby Hansen","doi":"10.1080/02699052.2024.2428404","DOIUrl":"10.1080/02699052.2024.2428404","url":null,"abstract":"Background: A significant portion of youth sustain a concussion every year, with around 30% experiencing persistent post-concussion symptoms (PPCS). Research has shown exercising just below the exertion level that provokes symptoms can lead to more rapid recovery. However, youth often struggle to adhere to exercise recommendations following concussion.Methods: We conducted structured qualitative interviews (n = 32) with concussed youth and their parents to examine factors influencing motivation to engage in exercise post-concussion. Questions were framed through the lens of Self-Determination Theory (SDT) and Thematic Analysis was used to code and analyze transcripts.Results: Four primary factors appeared to motivate youth to exercise after receiving a concussion: 1) social support, 2) accountability, 3) goal setting, and 4) structure. Utilizing the lens of SDT, one could theorize that including social support and accountability helped fulfill the need of relatedness, setting goals helped fulfill the need of autonomy, and providing program structure helped fulfill the need for competence.Conclusions: Our results suggest that Self-Determination Theory may be a useful frame for examining exercise adherence post-concussion. Incorporating social support, accountability, goal setting and structure could increase the effectiveness of exercise prescription post-concussion and should be the focus of further study.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"286-299"},"PeriodicalIF":1.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Significant initial hyperglycemia in young children with intracranial hemorrhage related to abuse.

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-14 DOI: 10.1080/02699052.2025.2478417

Melanie M Randall, Christine L S Lee, Colleen Walsh Lang, Luke R Sampson, Brian G Chen, Lance A Brown

{"title":"Significant initial hyperglycemia in young children with intracranial hemorrhage related to abuse.","authors":"Melanie M Randall, Christine L S Lee, Colleen Walsh Lang, Luke R Sampson, Brian G Chen, Lance A Brown","doi":"10.1080/02699052.2025.2478417","DOIUrl":"https://doi.org/10.1080/02699052.2025.2478417","url":null,"abstract":"Introduction: Abusive head injury is more common in younger children, with long lasting physical or neurologic impairments seen in many survivors. There is a close relationship between hyperglycemia and head injury, with hyperglycemia associated with worse outcomes. Our hypothesis is that abusive head injury patients are more likely to have significant hyperglycemia.Methods: This study is a retrospective review of pediatric emergency department patients less than three years with traumatic intracranial hemorrhage. Demographics, laboratory values, and imaging results were recorded.Results: In total, 179 patients were analyzed. The median initial glucose for abuse patients was 164 mg/dL. The median initial glucose for non-abuse patients was 99 mg/dL. Eight patients had glucose levels greater than 300 mg/dL. All of these patients were abuse victims. The initial glucose level was significant for the diagnosis of child abuse, ICU admission, need for neurosurgical intervention, and mortality.Discussion: Young children with intracranial hemorrhage and initial glucose levels greater than 300 mg/dL were all found to be abuse victims. A very high initial glucose can prompt a provider to evaluate for abusive head injury. In cases of a sick infant with glucose greater than 300 mg/dl, the consideration of abuse should play a prominent role in the differential.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-4"},"PeriodicalIF":1.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A child who suffered from HSV encephalitis and AE with positive anti-MOG results: a case report.

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-14 DOI: 10.1080/02699052.2025.2478431

Xilong Chen, Shixia Yue, Bin Yan, Taining Zhang, Bingying Zhou, Weikai Wang

{"title":"A child who suffered from HSV encephalitis and AE with positive anti-MOG results: a case report.","authors":"Xilong Chen, Shixia Yue, Bin Yan, Taining Zhang, Bingying Zhou, Weikai Wang","doi":"10.1080/02699052.2025.2478431","DOIUrl":"https://doi.org/10.1080/02699052.2025.2478431","url":null,"abstract":"Objective: To investigate the clinical manifestations of a pediatric case involving herpes simplex virus (HSV) encephalitis concurrent with autoimmune encephalitis (AE), which is characterized by a positive anti-myelin oligodendrocyte glycoprotein (MOG) antibody status.Results: A 12-year-old girl initially presented with symptoms of autoimmune encephalitis, including weakness and poor appetite, followed by headache, dizziness, and personality changes, which are indicative of disease progression. Cerebrospinal fluid routine biochemical tests demonstrated abnormal results. Cerebrospinal fluid mNGS results demonstrated human herpesvirus type I, and autoimmune encephalitis antibody tests suggested a positive result for anti-myelin oligodendrocyte glycoprotein (MOG) antibodies (1:100). Brain MRI revealed abnormal signals in the bilateral frontal lobes and dorsal thalamus. Therefore, diagnoses of herpes simplex virus encephalitis and autoimmune encephalitis were determined. After treatment with acyclovir, gamma globulin and hormones, the patient exhibited significant improvement in her symptoms.Conclusions: Children with herpes simplex virus encephalitis combined with autoimmune encephalitis may present with atypical clinical symptoms, and a positive anti-MOG antibody test is rarely observed, with no previous reports on this occurrence. The early detection of the relevant pathogens (in addition to timely reevaluation) can aid in accurate diagnosis. Moreover, antiviral and immunosuppressive therapy may significantly improve symptoms and patient prognosis.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-4"},"PeriodicalIF":1.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0