Brain injury最新文献_第10页

Looking beyond body structure and function: a scoping review of non-impairment impacts of stroke on adolescents 超越身体结构和功能：中风对青少年非损伤性影响的范围界定研究

IF 1.9 4区医学

Brain injury Pub Date : 2024-09-15 DOI: 10.1080/02699052.2024.2390858

Davina Lo, Monique Waite, Tanya A. Rose

引用次数: 0

Effectiveness of a psychoeducational program for caregivers of persons with acquired brain injury: a randomized controlled trial (EDUCA-V) 后天性脑损伤患者护理人员心理教育计划的效果：随机对照试验（EDUCA-V）

IF 1.9 4区医学

Brain injury Pub Date : 2024-09-12 DOI: 10.1080/02699052.2024.2401014

Eduardo González-Fraile, Ana I. Domínguez-Panchón, José Ignacio Quemada, Noemí Álvarez, Marga Pascual, Pilar Berzosa-Grande, Raymond Salvador, Edith Pomarol-Clotet, Manuel Martín-Carrasco

引用次数: 0

The diagnostic and prognostic utility of oxidative stress circulatory biomarkers in traumatic brain injury patients: a systematic review. 脑外伤患者氧化应激循环生物标志物的诊断和预后作用：系统综述。

IF 1.9 4区医学

Brain injury Pub Date : 2024-09-11 DOI: 10.1080/02699052.2024.2396017

Jake McDonnell,Kielan Wilson,Andrew R Stevens,David J Davies,Antonio Belli,Philip J O'Halloran

{"title":"The diagnostic and prognostic utility of oxidative stress circulatory biomarkers in traumatic brain injury patients: a systematic review.","authors":"Jake McDonnell,Kielan Wilson,Andrew R Stevens,David J Davies,Antonio Belli,Philip J O'Halloran","doi":"10.1080/02699052.2024.2396017","DOIUrl":"https://doi.org/10.1080/02699052.2024.2396017","url":null,"abstract":"OBJECTIVEThe objective of this review is to qualitatively appraise the available literature to evaluate the efficacy of circulatory systemic oxidative stress markers (OSMx) in determining the diagnosis and outcome of TBI.METHODSA systematic review was conducted of PubMed/Medline, Embase and Google Scholar databases per the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) for studies which employed serum or plasma OSMx analysis for diagnostic or prognostic purposes in patients with TBI.RESULTSEight studies were included. There were 654 patients across the eight studies, of which 518 (79.2%) patients had sustained a TBI. The heterogeneity between studies in terms of OSMxs analyzed ultimately made collective analysis inappropriate. Nevertheless, several studies highlighted the potential role of circulatory OSMx levels in determining the diagnosis (presence and severity) and prognosis (functional outcome and mortality) of TBI.CONCLUSIONThe care for patients with TBI remains a complex clinical challenge with a high morbidity and mortality profile. Evidenced by this review, circulatory OSMxs appear to have the potential to supplement current diagnostic measures, in addition to identifying new treatment strategies and monitoring recovery. Despite early promise, the evidence for such markers remains in its infancy and robust prospective studies are needed.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":"14 1","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142209950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TRPV4 modulation participates in paraoxon-induced brain injury via NMDA and NLRP3 regulation. TRPV4调节通过NMDA和NLRP3调控参与帕劳逊诱导的脑损伤

IF 1.5 4区医学

Brain injury Pub Date : 2024-08-23 Epub Date: 2024-05-07 DOI: 10.1080/02699052.2024.2351104

Shuai Wang, Huanhuan He, Yu Chen, Yaru Wang, Tingting Cui, Ninghong Ma

{"title":"TRPV4 modulation participates in paraoxon-induced brain injury via NMDA and NLRP3 regulation.","authors":"Shuai Wang, Huanhuan He, Yu Chen, Yaru Wang, Tingting Cui, Ninghong Ma","doi":"10.1080/02699052.2024.2351104","DOIUrl":"10.1080/02699052.2024.2351104","url":null,"abstract":"Background: Organophosphorus pesticide poisoning can lead to severe brain damage, but the specific mechanisms involved are not fully understood. Our research aims to elucidate the function of the TRPV4 ion channel in the development of brain injury induced by paraoxon (POX).Methods: In vivo, we examined the survival rate, behavioral seizures, histopathological alterations, NMDA receptor phosphorylation, as well as the expression of the NLRP3-ASC-caspase-1 complex and downstream inflammatory factors in the POX poisoning model following intervention with the TRPV4 antagonist GSK2193874. In vitro, we investigated the effects of GSK2193874 on NMDA-induced inward current, cell viability, cell death rate, and Ca2+ accumulation in primary hippocampal neurons.Results: The treatment with the TRPV4 antagonist increased the survival rate, suppressed the status epilepticus, improved pathological damage, and reduced the phosphorylation level of NMDA receptors after POX exposure. Additionally, it inhibited the upregulation of NLRP3 inflammasome and inflammatory cytokines expression after POX exposure. Moreover, the TRPV4 antagonist corrected the NMDA-induced increase in inward current and cell death rate, decrease in cell viability, and Ca2+ accumulation.Conclusion: TRPV4 participates in the mechanisms of brain injury induced by POX exposure through NMDA-mediated excitotoxicity and NLRP3-mediated inflammatory response.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"848-857"},"PeriodicalIF":1.5,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AMPK deficiency inhibits fatty acid oxidation in endothelial progenitor cells to aggravate impaired angiogenesis after ischemic stroke in hyperlipidemic mice. AMPK 缺乏会抑制内皮祖细胞的脂肪酸氧化，从而加重高脂血症小鼠缺血性中风后血管生成受损的情况。

IF 1.5 4区医学

Brain injury Pub Date : 2024-08-23 Epub Date: 2024-05-08 DOI: 10.1080/02699052.2024.2349776

Jian Zhu, Qiaojuan Shi, Xue Han, Mengyang Wang, Lu Zhang, Huazhong Ying, Bing Yu

{"title":"AMPK deficiency inhibits fatty acid oxidation in endothelial progenitor cells to aggravate impaired angiogenesis after ischemic stroke in hyperlipidemic mice.","authors":"Jian Zhu, Qiaojuan Shi, Xue Han, Mengyang Wang, Lu Zhang, Huazhong Ying, Bing Yu","doi":"10.1080/02699052.2024.2349776","DOIUrl":"10.1080/02699052.2024.2349776","url":null,"abstract":"Background: Hyperlipidemia is a risk factor for stroke, and worsens neurological outcome after stroke. Endothelial progenitor cells (EPCs), which become dysfunctional in cerebral ischemia, hold capacity to promote revascularization.Objective: We investigated the role of dyslipidemia in impairment of EPC-mediated angiogenesis in cerebral ischemic mice.Methods and results: The high fat diet (HFD)-fed mice following by ischemic stroke exhibited increased infarct volumes and neurological severity scores, and poorer angiogenesis. Bone marrow-EPCs treated with palmitic acid (PA) showed impaired functions and inhibited activity of AMP-activated protein kinase (AMPK). Notably, AMPK deficiency aggravated EPC dysfunction, further decreased mitochondrial membrane potential, and increased reactive oxygen species level in EPCs with PA treatment. Furthermore, the expression of fatty acid oxidation (FAO)-related genes was remarkably reduced, and carnitine palmitoyltransferase 1A (CPT1A) protein expression was downregulated in AMPK-deficient EPCs. AMPK deficiency aggravated neurological severity scores and angiogenesis in ischemic brain of HFD-fed mice, accompanied by suppressed protein level of CPT1A. EPC transplantation corrected impaired neurological severity scores and angiogenesis in AMPK-deficient mice.Conclusion: Our findings suggest that AMPK deficiency aggravates poor angiogenesis in ischemic brain by mediating FAO and oxidative stress thereby inducing EPC dysfunction in hyperlipidemic mice.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"835-847"},"PeriodicalIF":1.5,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140875813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal neurocognitive trajectories and risk factors in the first three months following pediatric concussion. 小儿脑震荡后头三个月的纵向神经认知轨迹和风险因素。

IF 1.5 4区医学

Brain injury Pub Date : 2024-08-23 Epub Date: 2024-05-05 DOI: 10.1080/02699052.2024.2347553

Daniel A P Geraghty, Vicki Anderson, Katherine Bray, Stephen J C Hearps, Fabian Fabiano, Franz E Babl, Gavin A Davis, Georgia M Parkin, Vanessa C Rausa, Nick Anderson, Vera Ignjatovic, Marc Seal, Michael Takagi

{"title":"Longitudinal neurocognitive trajectories and risk factors in the first three months following pediatric concussion.","authors":"Daniel A P Geraghty, Vicki Anderson, Katherine Bray, Stephen J C Hearps, Fabian Fabiano, Franz E Babl, Gavin A Davis, Georgia M Parkin, Vanessa C Rausa, Nick Anderson, Vera Ignjatovic, Marc Seal, Michael Takagi","doi":"10.1080/02699052.2024.2347553","DOIUrl":"10.1080/02699052.2024.2347553","url":null,"abstract":"Objective: To identify differential trajectories of neurocognitive outcomes following pediatric concussion and investigate predictors associated with patterns of recovery up to 3 months.Methods: 74 participants aged 8-17 years completed attention/working memory, processing speed, and executive function measures at 2 weeks, 1 month, and 3 months post-injury. We used principal component analysis to generate a composite of information processing. Group-based trajectory modeling identified latent trajectories. Multinominal logistic regression was used to examine associations between risk factors and trajectory groups.Results: We identified three trajectories of neurocognitive outcomes. The medium (54.6%) and high improving groups (35.8%) showed ongoing increase in information processing, while the low persistent group showed limited change 3 months post-injury. This group recorded below average scores on Digit Span Forward and Backward at 3 months. History of pre-injury headache was significantly associated with the persistent low scoring group, relative to the medium improving (p = 0.03) but not the high improving group (p = 0.09).Conclusions: This study indicates variability in neurocognitive outcomes according to three differential trajectories, with groups partially distinguished by preexisting child factors (history of frequent headaches). Modelling that accounts for heterogeneity in individual outcomes is essential to identify clinically meaningful indices that are indicative of children requiring intervention.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"764-772"},"PeriodicalIF":1.5,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-term behavioral and histological findings following a single concussive and repeated subconcussive brain injury in a rodent model. 在啮齿动物模型中进行单次脑震荡和反复亚脑震荡脑损伤后的短期行为和组织学研究结果。

IF 1.5 4区医学

Brain injury Pub Date : 2024-08-23 Epub Date: 2024-05-05 DOI: 10.1080/02699052.2024.2349144

Anna Marie Clay, Russell L Carr, Janice L DuBien, Filip To

{"title":"Short-term behavioral and histological findings following a single concussive and repeated subconcussive brain injury in a rodent model.","authors":"Anna Marie Clay, Russell L Carr, Janice L DuBien, Filip To","doi":"10.1080/02699052.2024.2349144","DOIUrl":"10.1080/02699052.2024.2349144","url":null,"abstract":"Primary objective: It is unclear of the correlation between a mild traumatic brain injury (mTBI) and repeated subconcussive (RSC) impacts with respect to injury biomechanics. Thus, the present study was designed to determine the behavioral and histological differences between a single mTBI impact and RSC impacts with subdivided cumulative kinetic energies of the single mTBI impact.Research design: Adult male Sprague-Dawley rats were randomly assigned to a single mTBI impact, RSC impact, sham, or repeated sham groups.Methods and procedures: Following a weight drop injury, anxiety-like behavior and general locomotive activity and were assessed using the open field test, while motor coordination was evaluated using a rotarod unit. Neuronal loss, astrogliosis, and microgliosis were assessed using NeuN, GFAP and Iba-1 immunohistochemistry. All assessments were undertaken at 3- and 7-days post impact.Main outcomes and results: No behavioral disturbances were observed in injury groups, however, both injury groups did lead to microgliosis following 3-days post-impact.Conclusions: No pathophysiological differences were observed between a single mTBI impact and RSC impacts of the same energy input. Even though a cumulative injury threshold for RSC impacts was not determined, a threshold still may exist where no pathodynamic shift occurs.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"827-834"},"PeriodicalIF":1.5,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hip displacement in children with post-neonatal cerebral palsy and acquired brain injury: a systematic review. 新生儿脑瘫和后天性脑损伤患儿的髋关节移位：系统综述。

IF 1.5 4区医学

Brain injury Pub Date : 2024-08-23 Epub Date: 2024-05-26 DOI: 10.1080/02699052.2024.2350049

Errolyn Boettcher-Hunt, Roslyn N Boyd, Noula Gibson

{"title":"Hip displacement in children with post-neonatal cerebral palsy and acquired brain injury: a systematic review.","authors":"Errolyn Boettcher-Hunt, Roslyn N Boyd, Noula Gibson","doi":"10.1080/02699052.2024.2350049","DOIUrl":"10.1080/02699052.2024.2350049","url":null,"abstract":"Aim: To systematically review the prevalence, risk factors and timing of onset of hip displacement in children with a post-neonatal (PNN) brain injury with regards to hip surveillance recommendations.Method: A search of PubMed, MEDLINE, Embase, CINAHL and Web of Science was conducted on 22nd February 2022. Studies were included if they reported presence of, and risk factors for, hip displacement in children with PNN brain injury. Data was extracted on patient characteristics, and analyzed in terms of risk factors of interest and timing of development of hip displacement.Results: Six studies met the inclusion criteria (n = 408 participants). All were cohort studies: five retrospective and one prospective. Rates of hip displacement ranged from 1% to 100%, and were higher in children with diffuse brain injury at an early age, who were non-ambulant and had spastic quadriplegia. Hip displacement and hip dislocation were first identified at one and three months respectively following PNN brain injury.Interpretation: Evidence on hip displacement in children with PNN brain injury is sparse and low quality. Children who remain non-ambulant after diffuse PNN brain injury before five years of age appear most at risk of developing progressive hip displacement and earlier hip surveillance is recommended.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"751-763"},"PeriodicalIF":1.5,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementation of the strengths model of case management for people with a traumatic brain injury: a qualitative pre-implementation study. 为脑外伤患者实施个案管理的优势模式：实施前定性研究。

IF 1.5 4区医学

Brain injury Pub Date : 2024-07-28 Epub Date: 2024-05-05 DOI: 10.1080/02699052.2024.2347548

Pascale Simard, Samuel Turcotte, Catherine Vallée, Marie-Eve Lamontagne

{"title":"Implementation of the strengths model of case management for people with a traumatic brain injury: a qualitative pre-implementation study.","authors":"Pascale Simard, Samuel Turcotte, Catherine Vallée, Marie-Eve Lamontagne","doi":"10.1080/02699052.2024.2347548","DOIUrl":"10.1080/02699052.2024.2347548","url":null,"abstract":"Introduction: People who sustain a traumatic brain injury (TBI) may have to live with permanent sequelae such as mental health problems, cognitive impairments, and poor social participation. The strengths-based approach (SBA) of case management has a number of positive impacts such as greater community integration but it has never been implemented for persons with TBI. To support its successful implementation with this population, it is essential to gain understanding of how the key components of the intervention are perceived within the organization applying the approach.Objectives: Documenting the barriers and facilitators in the implementation of the SBA as perceived by potential adopters.Methods: A qualitative pre-implementation study was conducted using semi-structured interviews with community workers and managers of the community organization where the SBA is to be implemented. Data were analyzed using a deductive approach based on the Consolidated Framework for Implementation Research (CFIR).Results: The major barriers are associated with the intervention (e.g. adaptability of the intervention) and the external context (e.g. the impact of the pandemic). Perceived facilitators are mainly associated with the internal context (e.g. compatibility with current values).Conclusion: The barriers and facilitators identified will inform the research team's actions to maximize the likelihood of successful implementation.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"734-741"},"PeriodicalIF":1.5,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-velocity penetrating brain injury: a review of the literature and illustrative case. 低速穿透性脑损伤：文献综述和案例说明。

IF 1.9 4区医学

Brain injury Pub Date : 2024-07-02 Epub Date: 2024-03-31 DOI: 10.1080/02699052.2024.2336067

Richard Cook, Laura Zima, Jawad Khazaal, John Williams

{"title":"Low-velocity penetrating brain injury: a review of the literature and illustrative case.","authors":"Richard Cook, Laura Zima, Jawad Khazaal, John Williams","doi":"10.1080/02699052.2024.2336067","DOIUrl":"10.1080/02699052.2024.2336067","url":null,"abstract":"Introduction: Low-velocity penetrating brain injury (LVPBI) is a class of brain injury where a foreign object violates the skull and damages the brain. Such injuries are rare and consequently understudied.Case: As such, we report an illustrative case of a 29-year-old female with a dense, plastic spike penetrating her right orbit and into her midbrain. After assessment with a CT scan and angiography, the object was removed with careful attention to possible vascular injury. The patient had an uncomplicated post-operative course and received antibiotic and antiepileptic prophylaxis. She was discharged on post-operative day 5, experiencing only mild left-sided weakness.Discussion: Common concerns regarding LVPBI include infection, post-traumatic epilepsy, and vascular injury. A review of published LVPBI cases over the past 20 years demonstrated that most cases (55.2%) are due to accidents. Of patients undergoing surgery, 43.4% underwent a craniotomy, and 22.8% underwent a craniectomy. Despite the grave nature of LVPBI, only 13.5% of the patients died. Additionally, 6.5% of patients developed an infection over their clinical course.Conclusion: In all, more reported cases further paint a picture of the current state of management and outcomes regarding LVPBI, paving the way for more cohesive guidelines to ensure the best possible patient outcomes.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"668-674"},"PeriodicalIF":1.9,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140329566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0