Brain injury最新文献

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Development and validation of an electronic health record-based algorithm for identifying TBI in the VA: A VA Million Veteran Program study. 开发和验证基于电子健康记录的算法,用于识别退伍军人事务部的创伤性脑损伤:退伍军人事务部百万退伍军人计划研究。
IF 1.5 4区 医学
Brain injury Pub Date : 2024-11-09 Epub Date: 2024-07-14 DOI: 10.1080/02699052.2024.2373920
Victoria C Merritt, Alicia W Chen, Clara-Lea Bonzel, Chuan Hong, Rahul Sangar, Sara Morini Sweet, Scott F Sorg, Catherine Chanfreau-Coffinier
{"title":"Development and validation of an electronic health record-based algorithm for identifying TBI in the VA: A VA Million Veteran Program study.","authors":"Victoria C Merritt, Alicia W Chen, Clara-Lea Bonzel, Chuan Hong, Rahul Sangar, Sara Morini Sweet, Scott F Sorg, Catherine Chanfreau-Coffinier","doi":"10.1080/02699052.2024.2373920","DOIUrl":"10.1080/02699052.2024.2373920","url":null,"abstract":"<p><p>The purpose of this study was to develop and validate an algorithm for identifying Veterans with a history of traumatic brain injury (TBI) in the Veterans Affairs (VA) electronic health record using VA Million Veteran Program (MVP) data. Manual chart review (<i>n</i> = 200) was first used to establish 'gold standard' diagnosis labels for TBI ('Yes TBI' vs. 'No TBI'). To develop our algorithm, we used PheCAP, a semi-supervised pipeline that relied on the chart review diagnosis labels to train and create a prediction model for TBI. Cross-validation was used to train and evaluate the proposed algorithm, 'TBI-PheCAP.' TBI-PheCAP performance was compared to existing TBI algorithms and phenotyping methods, and the final algorithm was run on all MVP participants (<i>n</i> = 702,740) to assign a predicted probability for TBI and a binary classification status choosing specificity = 90%. The TBI-PheCAP algorithm had an area under the receiver operating characteristic curve of 0.92, sensitivity of 84%, and positive predictive value (PPV) of 98% at specificity = 90%. TBI-PheCAP generally performed better than other classification methods, with equivalent or higher sensitivity and PPV than existing rules-based TBI algorithms and MVP TBI-related survey data. Given its strong classification metrics, the TBI-PheCAP algorithm is recommended for use in future population-based TBI research.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1084-1092"},"PeriodicalIF":1.5,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141615806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On-road driving remediation following acquired brain injury: a randomized controlled trial. 后天性脑损伤后的道路驾驶补救:随机对照试验。
IF 1.5 4区 医学
Brain injury Pub Date : 2024-11-09 Epub Date: 2024-07-12 DOI: 10.1080/02699052.2024.2376763
Louise Bassingthwaighte, Louise Gustafsson, Matthew Molineux, Ryan Bell, William Pinzon Perez, Darshan Shah
{"title":"On-road driving remediation following acquired brain injury: a randomized controlled trial.","authors":"Louise Bassingthwaighte, Louise Gustafsson, Matthew Molineux, Ryan Bell, William Pinzon Perez, Darshan Shah","doi":"10.1080/02699052.2024.2376763","DOIUrl":"10.1080/02699052.2024.2376763","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between on-road driving remediation and achieving fitness to drive following acquired brain injury.</p><p><strong>Design: </strong>Randomized controlled trial.</p><p><strong>Setting: </strong>Tertiary hospital outpatient driver assessment and rehabilitation service, Australia.</p><p><strong>Participants: </strong>Thirty-five participants (54.3% male), aged 18-65 years, 41 days-20 years post-acquired brain injury (including stroke, aneurysm, traumatic brain injury) recommended for on-road driving remediation following occupational therapy driver assessment were randomly assigned to intervention (<i>n</i> = 18) and waitlist control (<i>n</i> = 17) groups.</p><p><strong>Intervention: </strong>Intervention group received on-road driving remediation delivered by a qualified driving instructor in a dual-control vehicle. The waitlist control group completed a 6 week period of no driving-related remediation.</p><p><strong>Main measure: </strong>Fitness to drive rated following the conduct of an on-road occupational therapy driver assessment with a qualified driving instructor where outcome assessors were blinded to group allocation.</p><p><strong>Results: </strong>The intervention group were significantly more likely to achieve a fit to drive recommendation than no driving specific intervention (<i>p</i> = 0.003).</p><p><strong>Conclusion: </strong>Following comprehensive assessment, individualized on-road driving remediation programs devised by an occupational therapist with advanced training in driver assessment and rehabilitation and delivered by a qualified driving instructor are significantly associated with achieving fitness to drive after acquired brain injury.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1113-1124"},"PeriodicalIF":1.5,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141589601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conscious care: a proposed model to improve interprofessional care of patients with disorders of consciousness in the acute hospital setting. 意识护理:改善急症医院意识障碍患者跨专业护理的建议模式。
IF 1.5 4区 医学
Brain injury Pub Date : 2024-11-09 Epub Date: 2024-07-17 DOI: 10.1080/02699052.2024.2376767
Kristen Keech, Jessica Asiello
{"title":"Conscious care: a proposed model to improve interprofessional care of patients with disorders of consciousness in the acute hospital setting.","authors":"Kristen Keech, Jessica Asiello","doi":"10.1080/02699052.2024.2376767","DOIUrl":"10.1080/02699052.2024.2376767","url":null,"abstract":"<p><strong>Background: </strong>Forty percent of individuals within the Disorders of Consciousness (DoC) spectrum are misdiagnosed as in a vegetative state/unresponsive wakefulness syndrome (VS/UWS) when in fact they are minimally conscious or emerged, underscoring a need to optimize evaluation techniques and interprofessional care management.</p><p><strong>Primary objective: </strong>Conscious Care is a proposed care model that aims to improve interprofessional care of patients with DoC in the hospital setting. The aim of this paper is to describe this model's key ingredients and various components.</p><p><strong>Conclusions: </strong>This care model will advance clinician and caregiver preparedness to manage the complexities of this population and advocate for equal access to post-hospital medical and rehabilitative services. Evaluation and treatment of survivors of DoC should incorporate current evidence which drives continuous quality improvement and education to clinicians across the continuum of care. Immediate action must be taken to decrease the vulnerability and neglect of this marginalized population. Conscious Care is an innovative, sustainable solution that will improve interprofessional awareness of best practices and available science, strengthen care, and advocate for the right to quality of life that this population is so often denied.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1125-1132"},"PeriodicalIF":1.5,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141625945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors related to social inferencing performance in moderate-severe, chronic TBI. 中重度慢性创伤性脑损伤患者社会推理能力的相关因素。
IF 1.5 4区 医学
Brain injury Pub Date : 2024-10-14 Epub Date: 2024-06-04 DOI: 10.1080/02699052.2024.2361634
Eleanor S Birch, Brielle C Stark, Dawn Neumann
{"title":"Factors related to social inferencing performance in moderate-severe, chronic TBI.","authors":"Eleanor S Birch, Brielle C Stark, Dawn Neumann","doi":"10.1080/02699052.2024.2361634","DOIUrl":"10.1080/02699052.2024.2361634","url":null,"abstract":"<p><strong>Objective: </strong>Following traumatic brain injury (TBI), deficits in social cognition are common. Social inferencing is a crucial component of social cognition that enables an individual to understand the thoughts, feelings, and intentions of a communication partner when this information is not explicitly stated. Existing literature suggests a variety of factors contribute to social inferencing success (e.g. biological sex, executive functioning), yet findings are not conclusive, largely because these factors have been examined in isolation.</p><p><strong>Method: </strong>In this cross-sectional study, stepwise regression with cross validation was used to examine the extent that several theoretically motivated factors were associated with social inferencing (measured by performance on The Awareness of Social Inference Test [TASIT]) in adult participants with TBI (<i>n</i> = 105). Demographic information, executive functioning, aggression, emotional functioning measures, and participation in society were all examined in relation to social inferencing performance.</p><p><strong>Results: </strong>The findings confirm the importance of higher-level cognitive skills (i.e. executive functioning) in social inferencing, and advance the literature by underlining the potential importance of productive participation in social inferencing performance.</p><p><strong>Conclusion: </strong>This study innovatively highlights factors linked with social inferencing skills and, in doing so, how deficits in social inferencing might manifest in the lives of individuals with TBI.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"992-1003"},"PeriodicalIF":1.5,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141236700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology and outcomes of brain trauma in rural and urban populations: a systematic review and meta-analysis. 农村和城市人口脑外伤的流行病学和后果:系统回顾和荟萃分析。
IF 1.5 4区 医学
Brain injury Pub Date : 2024-10-14 Epub Date: 2024-06-05 DOI: 10.1080/02699052.2024.2361641
Julia Chequer de Souza, Geoffrey P Dobson, Celine J Lee, Hayley L Letson
{"title":"Epidemiology and outcomes of brain trauma in rural and urban populations: a systematic review and meta-analysis.","authors":"Julia Chequer de Souza, Geoffrey P Dobson, Celine J Lee, Hayley L Letson","doi":"10.1080/02699052.2024.2361641","DOIUrl":"10.1080/02699052.2024.2361641","url":null,"abstract":"<p><strong>Objective: </strong>To identify and describe differences in demographics, injury characteristics, and outcomes between rural and urban patients suffering brain injury.</p><p><strong>Data sources: </strong>CINAHL, Emcare, MEDLINE, and Scopus.</p><p><strong>Review methods: </strong>A systematic review and meta-analysis of studies comparing epidemiology and outcomes of rural and urban brain trauma was conducted in accordance with PRISMA and MOOSE guidelines.</p><p><strong>Results: </strong>36 studies with ~ 2.5-million patients were included. Incidence of brain injury was higher in males, regardless of location. Rates of transport-related brain injuries, particularly involving motorized vehicles other than cars, were significantly higher in rural populations (OR:3.63, 95% CI[1.58,8.35], <i>p</i> = 0.002), whereas urban residents had more fall-induced brain trauma (OR:0.73, 95% CI[0.66,0.81], <i>p</i> < 0.00001). Rural patients were 28% more likely to suffer severe injury, indicated by Glasgow Coma Scale (GCS)≤8 (OR:1.28, 95% CI[1.04,1.58], <i>p</i> = 0.02). There was no difference in mortality (OR:1.09, 95% CI[0.73,1.61], <i>p</i> = 0.067), however, urban patients were twice as likely to be discharged with a good outcome (OR:0.52, 95% CI[0.41,0.67], <i>p</i> < 0.00001).</p><p><strong>Conclusions: </strong>Rurality is associated with greater severity and poorer outcomes of traumatic brain injury. Transport accidents disproportionally affect those traveling on rural roads. Future research recommendations include addition of prehospital data, adequate follow-up, standardized measures, and sub-group analyses of high-risk groups, e.g. Indigenous populations.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"953-976"},"PeriodicalIF":1.5,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141247161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of hypertonic saline infusion in management of traumatic brain injury: an updated systematic review and meta-analysis of randomized controlled trials. 输注高渗盐水治疗脑外伤的效果:随机对照试验的最新系统回顾和荟萃分析。
IF 1.5 4区 医学
Brain injury Pub Date : 2024-10-14 Epub Date: 2024-06-10 DOI: 10.1080/02699052.2024.2363340
Lixin Cai, Wei He
{"title":"Effectiveness of hypertonic saline infusion in management of traumatic brain injury: an updated systematic review and meta-analysis of randomized controlled trials.","authors":"Lixin Cai, Wei He","doi":"10.1080/02699052.2024.2363340","DOIUrl":"10.1080/02699052.2024.2363340","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to find out the efficacy of using Hypertonic saline solution (HSS) over mannitol in the management of TBI by comparing their performance in improving different outcomes.</p><p><strong>Methods: </strong>Electronic databases were searched for randomized controlled trials (RCTs) assessing the impact of HSS vs. mannitol on ICP in patients who suffered TBI. Outcomes of interest were mortality, neurologic functional outcomes, risk ratio (RR) of successful ICP treatment, reduction in ICP after 30-60 and 90-120 min, improvement in cerebral perfusion pressure (CPP) at 30-60 and 90-120 min, and also treatment failure. Evaluations were reported as RR or mean difference (MD) with 95% confidence intervals (CIs) using weighted random-effects models.</p><p><strong>Results: </strong>The analysis included 624 patients from 15 RCTs. HSS infusion had a significant impact on the improvement of CPP at 30-60 min [MD = 5.54, 95% CI (3.04, 8.03),<i>p</i> < 0.001] compared to mannitol. However, results yielded no significant difference between HSS and mannitol in terms of mortality, neurologic functional outcomes, successful ICP treatment, reduction in ICP after 30-60 min and 90-120 min, improvement in CPP at 90-120 min, and treatment failure.</p><p><strong>Conclusion: </strong>HSS and mannitol are both effective treatments for elevated ICP due to TBI. However, further research is required to derive a better comparison.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"977-984"},"PeriodicalIF":1.5,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141295568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does early exercise intolerance effect time to return to play, symptom burden, neurocognition, Vestibular-Ocular-Motor (VOM) function and academic ability in acutely concussed student-athletes? 早期运动不耐受是否会影响急性脑震荡学生运动员重返赛场的时间、症状负担、神经认知、前庭-眼球-运动(VOM)功能和学习能力?
IF 1.5 4区 医学
Brain injury Pub Date : 2024-10-14 Epub Date: 2024-06-23 DOI: 10.1080/02699052.2024.2367477
K Glendon, G Blenkinsop, A Belli, M T G Pain
{"title":"Does early exercise intolerance effect time to return to play, symptom burden, neurocognition, Vestibular-Ocular-Motor (VOM) function and academic ability in acutely concussed student-athletes?","authors":"K Glendon, G Blenkinsop, A Belli, M T G Pain","doi":"10.1080/02699052.2024.2367477","DOIUrl":"10.1080/02699052.2024.2367477","url":null,"abstract":"<p><strong>Introduction: </strong>Early Exercise Intolerance (EEI) is associated with delayed recovery and longer time to Return To Play (RTP), but this has not been established.Participants; (<i>n</i> = 52, male <i>n</i> = 30) UK university-aged rugby-union student-athletes.</p><p><strong>Methods: </strong>Student-athletes completed baseline screening (July-October 2021 and 2022). The test battery was repeated within 48 h, 4, 8 and 14 days after a Sports-Related Concussion (SRC) with the Buffalo Concussion Bike or Treadmill Test to set sub-symptom heart rate threshold. Student-athletes then completed a controlled early exercise protocol in-between reassessment (days 3, 5-7 and 9-13). Those with EEI were compared to those with early-exercise tolerance.</p><p><strong>Outcome measures: </strong>Post-Concussion Symptom Scale, Immediate Post-Concussion and Cognitive Test, Vestibular-Ocular Motor Screening Tool and the Revised Perceived Academic Impact Tool.</p><p><strong>Results: </strong>EEI was seen throughout the initial 14-days post-SRC (23.8%, 22.4%, 25.5%. 25.0%). EEI was associated with a slower reaction time within 48 h (-0.01 (-0.030-0.043) Vs 0.06 (0.033-0.24), <i>p</i> = 0.004) and greater VOMS scores within 48 h; (0.00 (0.00-4.00) Vs 5.50 (2.75-9.00), <i>p</i> = 0.016) and 4 days (0.00 (0.00-2.00) Vs 5.00 (0.00-6.00), <i>p</i> = 0.044). RTP was 12.5 days longer in those with EEI at 14-days post-SRC.</p><p><strong>Conclusion: </strong>EEI is prevalent following an SRC in university-aged student-athletes and was associated with delayed recovery and RTP.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1004-1014"},"PeriodicalIF":1.5,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rare case of herpes simplex virus encephalitis from viral reactivation following surgically treated traumatic brain injury. 一例罕见的脑外伤手术治疗后病毒再激活引起的单纯疱疹病毒脑炎。
IF 1.5 4区 医学
Brain injury Pub Date : 2024-10-14 Epub Date: 2024-07-04 DOI: 10.1080/02699052.2024.2370834
Abhiraj D Bhimani, Daniel D Cummins, Roshini Kalagara, Sumanth Chennareddy, Zachary L Hickman
{"title":"A rare case of herpes simplex virus encephalitis from viral reactivation following surgically treated traumatic brain injury.","authors":"Abhiraj D Bhimani, Daniel D Cummins, Roshini Kalagara, Sumanth Chennareddy, Zachary L Hickman","doi":"10.1080/02699052.2024.2370834","DOIUrl":"10.1080/02699052.2024.2370834","url":null,"abstract":"<p><strong>Objective: </strong>Herpes simplex virus encephalitis (HSVE) is associated with significant morbidity and mortality. Here, we present the occurrence of HSVE in a 36-year-old immunocompetent patient following craniotomy for a traumatic acute subdural hematoma (ASDH).</p><p><strong>Methods: </strong>Imaging after four days of progressive headache following a fall with head-strike demonstrated a 1 cm thick left holohemispheric ASDH with significant cerebral compression, edema, and 8 mm of left-to-right midline shift, and an emergent craniotomy and ASDH evacuation were performed, with additional treatment needed for reaccumulation. Postoperatively, the patient developed a worsening leukocytosis, became febrile, and was hypotensive requiring vasopressor support.</p><p><strong>Results: </strong>Despite empiric antibiotics, the patient remained persistently febrile with significant leukocytosis. Repeat head CT showed a new left insular hypodensity and a subsequent viral encephalitis panel was positive for HSV-1. The patient was then started on intravenous acyclovir, with progressive neurological exam improvement. Of note, the patient was noted to have a positive serum HSV-1 IgG antibody titer, indicative of prior infection.</p><p><strong>Conclusions: </strong>Given the known systemic immunosuppression in brain injury and the high prevalence of HSV seropositivity, clinicians should consider the possibility of HSVE from HSV reactivation in TBI patients with persistent fever, leukocytosis, and/or neurological deficits without an obvious etiology.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1046-1051"},"PeriodicalIF":1.5,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141497096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing traumatic brain injury emergency care: the impact of grading and zoning nursing management. 加强脑外伤急救护理:分级和分区护理管理的影响。
IF 1.5 4区 医学
Brain injury Pub Date : 2024-10-14 Epub Date: 2024-06-06 DOI: 10.1080/02699052.2024.2361631
Yan-Qian Ge, Si-Yuan Ma, Hui Yu, Xing Lu, Li Ding, Jia-Yan Zhang
{"title":"Enhancing traumatic brain injury emergency care: the impact of grading and zoning nursing management.","authors":"Yan-Qian Ge, Si-Yuan Ma, Hui Yu, Xing Lu, Li Ding, Jia-Yan Zhang","doi":"10.1080/02699052.2024.2361631","DOIUrl":"10.1080/02699052.2024.2361631","url":null,"abstract":"<p><strong>Objective: </strong>This research aimed to evaluate the impact of grading and zoning nursing management on traumatic brain injury (TBI) patients' emergency treatment outcomes.</p><p><strong>Methods: </strong>This randomized controlled trial included 200 TBI patients. They were treated with a conventional care (control group, <i>n</i> = 100) and a novel grading and zoning approach (study group, <i>n</i> = 100), respectively. This innovative model organized care into levels based on urgency and complexity, facilitating targeted medical response and resource allocation. Key metrics compared included demographic profiles, consultation efficiency (time metrics and emergency treatment rates), physiological parameters (HR, RR, MAP, SpO<sub>2</sub>, RBS), and patient outcomes (hospital and ICU stays, complication rates, and emergency outcomes).</p><p><strong>Results: </strong>The study group demonstrated significantly improved consultation efficiency, with reduced times for physician visits, examinations, emergency stays, and specialist referrals (all <i>p</i> < 0.001), alongside a higher emergency treatment rate (93% vs. 79%, <i>p</i> = 0.004), notably better physiological stability, improved HR, RR, MAP, SpO<sub>2</sub> and RBS (<i>p</i> < 0.001), shorter hospital and ICU stays, fewer complications, and superior emergency outcomes.</p><p><strong>Conclusion: </strong>Grading and zoning nursing management substantially enhances TBI patients' emergency care efficiency and clinical outcomes, suggesting a viable model for improving emergency treatment protocols.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"985-991"},"PeriodicalIF":1.5,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141282945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Personalized, parcel-guided non-invasive transcranial magnetic stimulation for the treatment of post-concussive syndrome: safety and proof of concept. 个性化、包裹引导的非侵入性经颅磁刺激治疗脑震荡后综合征:安全性和概念验证。
IF 1.5 4区 医学
Brain injury Pub Date : 2024-10-14 Epub Date: 2024-07-04 DOI: 10.1080/02699052.2024.2371975
Si Jie Tang, Jonas Holle, Nicholas B Dadario, Mark Ryan, Olivia Lesslar, Charles Teo, Michael Sughrue, Jacky Yeung
{"title":"Personalized, parcel-guided non-invasive transcranial magnetic stimulation for the treatment of post-concussive syndrome: safety and proof of concept.","authors":"Si Jie Tang, Jonas Holle, Nicholas B Dadario, Mark Ryan, Olivia Lesslar, Charles Teo, Michael Sughrue, Jacky Yeung","doi":"10.1080/02699052.2024.2371975","DOIUrl":"10.1080/02699052.2024.2371975","url":null,"abstract":"<p><strong>Objective: </strong>To determine the safety and proof of concept of a parcel-guided, repetitive Transcranial Magnetic Stimulation (rTMS) in patients who develop a heterogeneous array of symptoms, known collectively as post-concussive syndrome (PCS), following traumatic brain injury (TBI).</p><p><strong>Methods: </strong>We performed a retrospective review of off-label, individualized, parcel-guided rTMS in 19 patients from December 2020 to May 2023. Patients had at least one instance of mild, moderate, or severe TBI and developed symptoms not present prior to injury. rTMS targets were identified based on machine learning connectomic software using functional connectivity anomaly matrices compared to healthy controls. EuroQol (EQ-5D), as a measurement of quality of life, and additional questionnaires dependent on individual's symptoms were submitted prior to, after, and during follow-up from rTMS.</p><p><strong>Results: </strong>Nineteen patients showed improvement in EQ-5D and Rivermead Post Concussion Symptoms Questionnaires - 3 after treatment and follow-up. For nine patients who developed depression, five (55%) attained response and remission based on the Beck Depression Inventory after treatment. Eight of ten patients with anxiety had a clinically significant reduction in Generalized Anxiety Disorder-7 scores during follow-up.</p><p><strong>Conclusion: </strong>Parcel-guided rTMS is safe and may be effective in reducing PCS symptoms following TBI and should incite further controlled studies.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1015-1025"},"PeriodicalIF":1.5,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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