Brain injuryPub Date : 2024-06-06Epub Date: 2024-03-12DOI: 10.1080/02699052.2024.2328807
Claudia Niño, Darwin Cohen, José D Guerra
{"title":"Hyperosmolar therapies for neurological deterioration in mild and moderate traumatic brain injury: towards new research.","authors":"Claudia Niño, Darwin Cohen, José D Guerra","doi":"10.1080/02699052.2024.2328807","DOIUrl":"10.1080/02699052.2024.2328807","url":null,"abstract":"<p><p>The scoping review by Nicolò Marchesini and colleagues about the use of hyperosmolar therapies (HTs) in patients with traumatic brain injury (TBI) points out a significant gap in scientific literature regarding this topic. Although there are few high-quality recommendations, it is important to provide care under certain physiologic parameters. Through this letter we comment on the importance of guidelines to administer and monitor the use of HTs in the Neuro-ICU.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"583-584"},"PeriodicalIF":1.9,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140101044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2024-06-06Epub Date: 2024-03-13DOI: 10.1080/02699052.2024.2328307
S A Balart-Sánchez, M Bittencourt, J van der Naalt, N M Maurits
{"title":"Lower cognitive reserve is related to worse working memory performance in older adults after mTBI. An ERP study.","authors":"S A Balart-Sánchez, M Bittencourt, J van der Naalt, N M Maurits","doi":"10.1080/02699052.2024.2328307","DOIUrl":"10.1080/02699052.2024.2328307","url":null,"abstract":"<p><strong>Objective: </strong>Older adults (OA) after mild traumatic brain injury (mTBI) have a high risk of developing persistent post-injury cognitive impairments. Lower pre-morbid cognitive reserve (CR) is increasingly investigated as a risk factor for cognitive dysfunction in OA. However, how CR protects against effects of mTBI at the brain level remains largely understudied.</p><p><strong>Methods: </strong>We examined 22 OA who sustained mTBI (mean 67.69 years, SD 5.11) in the sub-acute phase and 15 age- and CR-matched healthy OA (mean 68 years, SD 5.55) performing a three-level visual N-back task using electroencephalography. We calculated inverse efficiency scores of performance from accuracy and reaction times. Event-related potentials served as neurocognitive correlates of attentional (P2) and working memory (P3) processing.</p><p><strong>Results: </strong>Overall, mTBI OA performed worse than healthy OA (<i>p</i> = 0.031). Lower CR generally decreased performance (<i>p</i> < 0.001). Furthermore, with increasing task difficulty, task performance was more affected by CR (<i>p</i> = 0.004). At the brain level, P2 amplitude was lower in mTBI OA than in healthy OA (<i>p</i> = 0.05). There was no clear effect of CR on P2 or P3 measures.</p><p><strong>Conclusion: </strong>As mTBI OA with lower CR performed worse on a working-memory task, lower CR may be a risk factor for worse recovery after mTBI in this group.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"550-558"},"PeriodicalIF":1.9,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140118757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2024-06-06Epub Date: 2024-03-21DOI: 10.1080/02699052.2024.2332770
Mathew J Wingerson, Baylie Schmitz, Katherine L Smulligan, Gregory A Walker, Samantha Magliato, Julie C Wilson, David R Howell
{"title":"Concussion symptom presentation and clinical recovery among pediatric athletes: comparing concussions sustained during school and summer months.","authors":"Mathew J Wingerson, Baylie Schmitz, Katherine L Smulligan, Gregory A Walker, Samantha Magliato, Julie C Wilson, David R Howell","doi":"10.1080/02699052.2024.2332770","DOIUrl":"10.1080/02699052.2024.2332770","url":null,"abstract":"<p><strong>Objective: </strong>We examined post-concussion symptom presentation, exercise, and sleep among pediatric athletes who sustained concussion during the school year vs. summer months.</p><p><strong>Methods: </strong>We evaluated athletes 6-18 years old within 21-days of concussion. They reported symptoms (Health and Behavior Inventory), with cognitive/somatic domain sub-scores calculated, and indicated if they had exercised or experienced sleep problems since injury. We grouped patients by injury season: summer months (June-August) vs. school year (September-May).</p><p><strong>Results: </strong>350 patients (14.4 ± 2.4 years old; 37% female; initial visit 8.8 ± 5.3 days post-concussion) were seen for care: 24% sustained a concussion during summer months, 76% during the school year. Lower cognitive (median = 7 [IQR = 1, 15] vs. 9.5 [4, 17]; <i>p</i> = 0.01), but not somatic (7 [2.5, 11] vs. 8 [4, 13]; <i>p</i> = 0.06), HBI scores were observed for patients injured during the summer. Groups were similar in proportion exercising (16% vs 17%) and endorsing sleep problems (29% vs 31%). After adjustments, sustaining a concussion during the summer predicted total (β=-3.43; 95%CI = -6.50, -0.36; <i>p</i> = 0.029) and cognitive (β = -2.29; 95%CI = -4.22, -0.36; <i>p</i> = 0.02), but not somatic (β=-1.46; 95%CI = -2.84, -0.08; <i>p</i> = 0.04), symptom severity.</p><p><strong>Conclusion: </strong>Pediatric patients with concussion may present with greater cognitive symptoms during the school year, compared to summer months.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"574-582"},"PeriodicalIF":1.9,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2024-06-06Epub Date: 2024-03-05DOI: 10.1080/02699052.2024.2326054
Kathy S Chiou, Jessica Stump, Peggy Reisher, Lance Trexler
{"title":"Community resource facilitation use by ethnic minority groups with traumatic brain injury in the Midwestern United States.","authors":"Kathy S Chiou, Jessica Stump, Peggy Reisher, Lance Trexler","doi":"10.1080/02699052.2024.2326054","DOIUrl":"10.1080/02699052.2024.2326054","url":null,"abstract":"<p><strong>Objective: </strong>This study surveyed the use of community-based resource facilitation (RF) services by ethnic minority survivors of traumatic brain injury (TBI) living in the Midwestern United States.</p><p><strong>Method: </strong>Past records of RF use by survivors of TBI were reviewed. Demographics and patterns of RF use across 3 ethnic groups were documented. Reported barriers to community integration related to ethnic identity were identified using Chi-square test of independence.</p><p><strong>Results: </strong>Ethnic minority survivors were less likely to use RF services than white survivors. Caucasian women and men utilized RF services at similar rates, whereas more African American men and Latina women used RF services. Caucasians received information about RF from a greater variety of sources than ethnic minority survivors. Ethnic identity was significantly associated with greater reported needs for TBI awareness.</p><p><strong>Conclusions: </strong>A pattern of differential RF use by survivors from ethnic minority groups was noted, suggesting potential socio-cultural influences on help-seeking behavior after TBI. These factors should be considered to develop more accessible and equitable strategies of RF service referral and support. Future investigations of cultural perspectives of TBI and injury-related services may improve understanding of the likelihood and necessity of community-based RF service use by diverse populations.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"531-538"},"PeriodicalIF":1.5,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140038751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Modification of heart rate variability induced by focal muscle vibration in patients with severe acquired brain injury.","authors":"Costanza Pazzaglia, Cristina Cuccagna, Dario Mattia Gatto, Silvia Giovannini, Augusto Fusco, Letizia Castelli, Luca Padua","doi":"10.1080/02699052.2024.2311335","DOIUrl":"10.1080/02699052.2024.2311335","url":null,"abstract":"<p><strong>Background/purpose: </strong>Heart rate variability (HRV) is a biomarker of autonomic nervous system (ANS) reaction in persons with severe acquired brain injury (sABI) who undergo a rehabilitation treatment, such as focal muscle vibration (FMV).This study aims to evaluate if and how FMV can modulate HRV and to compare potential differences in FMV modulation in HRV between patients with sABI and healthy controls.</p><p><strong>Methods: </strong>Ten patients with sABI and seven healthy controls have been recruited. Each individual underwent the same stimulation protocol (four consecutive trains of vibration of 5 minutes each with a 1-minute pause). HRV was analyzed through the ratio of frequency domain heart-rate variability (LF/HF).</p><p><strong>Results: </strong>In the control group, after performing FMV, a significant LF/HF difference was observed in the in the second vibration session compared to the POST phase. Patients with SABI treated on the affected side showed a statistically significant LF/HF difference in the PRE compared to the first vibration session.</p><p><strong>Conclusion: </strong>These preliminary results suggest that FMV may modify the cardiac ANS activity in patients with sABI.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"436-442"},"PeriodicalIF":1.9,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139995587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2024-05-11Epub Date: 2024-03-05DOI: 10.1080/02699052.2024.2318595
Emily Kroshus, Mary Kathleen Steiner, Sara P D Chrisman, K Casey Lion, Frederick Rivara, Sarah J Lowry, Bonnie Strelitz, Eileen J Klein
{"title":"Improving post-concussion discharge education for families seeking emergency department care: intervention development.","authors":"Emily Kroshus, Mary Kathleen Steiner, Sara P D Chrisman, K Casey Lion, Frederick Rivara, Sarah J Lowry, Bonnie Strelitz, Eileen J Klein","doi":"10.1080/02699052.2024.2318595","DOIUrl":"10.1080/02699052.2024.2318595","url":null,"abstract":"<p><strong>Background: </strong>Pediatric emergency departments (ED) are where many families receive post-concussion medical care and thus an important context for helping parents build skills to support their child after discharge.</p><p><strong>Objective: </strong>Develop a strategy for increasing parent provision of emotional and instrumental support to their child after discharge and conduct a pilot test of this strategy's acceptability.</p><p><strong>Methods: </strong>In a large pediatric ED in the United States, we partnered with parents (<i>n</i> = 15) and clinicians (<i>n</i> = 15) to understand needs and constraints related to discharge education and to operationalize a strategy to feasibly address these needs. This produced a brief daily text message intervention for parents for 10 days post-discharge. We used a sequential cohort design to assess the acceptability this intervention and its efficacy in changing parenting practices in the 2-weeks post-discharge (<i>n</i> = 98 parents).</p><p><strong>Results: </strong>Parents who received the messaging intervention rated it as highly acceptable and had meaningfully higher scores for emotionally supportive communication with their child in the two weeks post-discharge than parents in the control condition (Cohen's d = 0.65, <i>p</i> = 0.021).</p><p><strong>Conclusions: </strong>This brief messaging intervention is a promising strategy for enhancing discharge education post-concussion that warrants further evaluation.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"479-488"},"PeriodicalIF":1.5,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11283255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2024-05-11Epub Date: 2024-02-20DOI: 10.1080/02699052.2024.2318588
Gregorio Sorrentino, Eléonore Bayen, Hugo Câmara-Costa, Leila Francillette, Hanna Toure, Anne Laurent-Vannier, Philippe Meyer, Georges Dellatolas, Mathilde Chevignard
{"title":"Long-term burden of informal caregiver 7-years after severe childhood traumatic brain injury in the traumatisme grave de l'Enfant (TGE) study.","authors":"Gregorio Sorrentino, Eléonore Bayen, Hugo Câmara-Costa, Leila Francillette, Hanna Toure, Anne Laurent-Vannier, Philippe Meyer, Georges Dellatolas, Mathilde Chevignard","doi":"10.1080/02699052.2024.2318588","DOIUrl":"10.1080/02699052.2024.2318588","url":null,"abstract":"<p><strong>Objective: </strong>To investigate reported burden by the Primary Family Caregiver (PFC) 7-years after severe pediatric traumatic brain injury in the TGE (Traumatisme Grave de l'Enfant) longitudinal study.</p><p><strong>Methods: </strong>Subjective burden was estimated with the Zarit Burden Inventory (ZBI) in 36 PFC (parents), who rated their own health status (Medical Outcome Study Short Form-12), family functioning and their child's level of care and needs (Pediatric/Adult Care And Needs Scale [PCANS/CANS]). Data collection included: child and PFC sociodemographic characteristics, injury-related factors, 'objective' (e.g. overall level of disability: Glasgow Outcome Scale - Extended, GOS-E/GOS-E-Peds) and 'subjective' outcomes (e.g. participation, behavior, executive functions, quality of life and fatigue).</p><p><strong>Results: </strong>25% of PFC reported mild-moderate burden, and 19% moderate-severe burden. Higher burden correlated with worse outcomes in all 'subjective' PFC-rated outcomes, and with self-reported participation. The ZBI correlated strongly with CANS/PCANS and GOS-E/GOS-E-Peds. Overall level of disability and PFC-reported executive functioning explained 62% of the ZBI variance. For equal levels of disability, burden was higher when PFC reported a 'negative' picture of their child.</p><p><strong>Conclusion: </strong>Significant PFC-reported burden 7-years post-injury was associated with overall disability and 'subjective' PFC-rated outcomes. Factors influencing parental burden in the long term should be identified and psychological support implemented over time.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"467-478"},"PeriodicalIF":1.9,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2024-05-11Epub Date: 2024-02-25DOI: 10.1080/02699052.2024.2318599
Charles Gervais, Danny Hjeij, Laura Fernández-Puerta, Caroline Arbour
{"title":"Non-pharmacological interventions for sleep disruptions and fatigue after traumatic brain injury: a scoping review.","authors":"Charles Gervais, Danny Hjeij, Laura Fernández-Puerta, Caroline Arbour","doi":"10.1080/02699052.2024.2318599","DOIUrl":"10.1080/02699052.2024.2318599","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to conduct a scoping review to determine the nature, variety, and volume of empirical evidence on nonpharmacological interventions for sleep disturbances with potential implications for fatigue in adults sustaining a traumatic brain injury (TBI).</p><p><strong>Methods: </strong>A systematic literature search was conducted across four databases to identify primary studies testing a single non-pharmacological intervention or a combination of non-pharmacological interventions for sleep disturbances and fatigue in community-dwelling adults with TBI.</p><p><strong>Results: </strong>Sixteen studies were reviewed addressing six non-pharmacological interventions for sleep disruptions and fatigue after TBI including light therapy, cognitive-behavioral therapy, warm footbath application, shiatsu, and sleep hygiene protocol. Non-pharmacological interventions involving light or cognitive-behavioral therapy were reported in 75% of the studies. Actigraphy-based estimation of total sleep time and subjective level of fatigue were frequent outcomes.</p><p><strong>Conclusion: </strong>While this scoping review has utility in describing existing non-pharmacological approaches to manage sleep and fatigue after TBI, the findings suggest that interventions are often developed without considering TBI individuals' source of motivation and the need for support in self-administration. Future studies may achieve greater sustainability by considering the evolving needs of TBI patients and their families and the drivers and barriers that might influence non-pharmacological intervention use at home.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"403-416"},"PeriodicalIF":1.9,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139970938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2024-05-11Epub Date: 2024-02-08DOI: 10.1080/02699052.2024.2309258
Justin E Karr, Grant L Iverson, Nancy Boudreau, Ross Zafonte
{"title":"Treatment of chronic symptoms following mild traumatic brain injury with transcranial LED: a sham run-in pilot study of photobiomodulation therapy.","authors":"Justin E Karr, Grant L Iverson, Nancy Boudreau, Ross Zafonte","doi":"10.1080/02699052.2024.2309258","DOIUrl":"10.1080/02699052.2024.2309258","url":null,"abstract":"<p><strong>Primary objective: </strong>We evaluated whether photobiomodulation with red/near infrared light applied transcranially via light emitting diodes (LED) was associated with reduced symptoms and improved cognitive functioning in patients with chronic symptoms following mild traumatic brain injury.</p><p><strong>Research design: </strong>Participants (3 men, 6 women; 22-61 years-old) underwent a 6-week intervention involving 18 40-minute transcranial LED treatment sessions.</p><p><strong>Methods and procedures: </strong>Reliable change indices were calculated for 10 neuropsychological test scores and 3 self-report questionnaires of subjective cognition, post-concussion symptoms, and depression at baseline and following treatment. Questionnaires were also administered after 2-week sham and at 1-month and 2-month follow-ups.</p><p><strong>Main outcome and results: </strong>Only 2 participants improved on neuropsychological testing. On questionnaires, 4 reported improved cognition, 5 reported improved post-concussion symptoms, and 3 reported improved depression. Significant improvement in 2 or more domains was reported by 4 participants and mostly maintained at both follow-ups.</p><p><strong>Conclusions: </strong>Most participants did not improve on neuropsychological testing. A minority self-reported improvement in symptoms, potentially explained by the intervention, psychiatric medication changes, placebo effects, or other factors. Selecting participants with different clinical characteristics, and dosing and delivery system changes, may produce different results. A study design accounting for placebo effects appears warranted in future trials.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"425-435"},"PeriodicalIF":1.9,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139701724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2024-05-11Epub Date: 2024-02-07DOI: 10.1080/02699052.2024.2311346
Ela Lazeron-Savu, Bert Lenaert, Jeanette Dijkstra, Rudolf Ponds, Caroline van Heugten
{"title":"Feasibility of a novel blended-care intervention for fatigue after acquired brain injury: a pilot study of the Tied by Tiredness intervention.","authors":"Ela Lazeron-Savu, Bert Lenaert, Jeanette Dijkstra, Rudolf Ponds, Caroline van Heugten","doi":"10.1080/02699052.2024.2311346","DOIUrl":"10.1080/02699052.2024.2311346","url":null,"abstract":"<p><strong>Purpose: </strong>Evidence-based treatments for fatigue after brain injury are scarce and often not personalized. An approach to foster personalization is Experience Sampling Methodology (ESM), consisting of repeated daily measurements of fatigue and related factors in daily life. We investigated the feasibility and usability of a novel six-week ESM-based intervention for fatigue after brain injury.</p><p><strong>Materials and methods: </strong>Ten individuals with acquired brain injury (six men; four women) aged between 36-70 years (<i>M</i> = 53.3, SD = 12.9) used a mHealth application for three days each week during six-weeks; seven completed the intervention. Momentary fatigue, activities, mood, worrying, and social context were assessed with ESM and participants received weekly personalized feedback by a therapist..</p><p><strong>Results: </strong>56% of ESM-questionnaires (568/1008) were completed, providing detailed insights into individual fatigue patterns. No statistically significant decrease in response rate was found over the course of treatment. Qualitative feedback from participants revealed increased insight into factors underlying fatigue, and no problems with treatment duration or difficulties using the app. Five participants showed a decline in fatigue level during treatment.</p><p><strong>Conclusions: </strong>This pilot study provides initial support for the feasibility and usability of this novel blended-care intervention, aimed at alleviating fatigue through personalized feedback and treatment strategies.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"448-458"},"PeriodicalIF":1.9,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139701797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}