Brain injury最新文献

Examining longitudinal changes in alexithymia and depressive symptoms following acquired brain injury. 后天性脑损伤后述情障碍和抑郁症状的纵向变化

IF 1.5 4区医学

Brain injury Pub Date : 2026-09-03 DOI: 10.1080/02699052.2026.2726455

Priscilla Prince, Kristin Naragon-Gainey, Rodrigo Becerra, Michael Weinborn, Carmela F Pestell

{"title":"Examining longitudinal changes in alexithymia and depressive symptoms following acquired brain injury.","authors":"Priscilla Prince, Kristin Naragon-Gainey, Rodrigo Becerra, Michael Weinborn, Carmela F Pestell","doi":"10.1080/02699052.2026.2726455","DOIUrl":"https://doi.org/10.1080/02699052.2026.2726455","url":null,"abstract":"Objective: Alexithymia and depressive symptoms are common following acquired brain injury (ABI). However, their longitudinal relationship remains unclear. This study examined trajectories of alexithymia and depressive symptoms over 24 months post-injury and tested their temporal associations.Methods: Adults with ABI (N = 116) (mean age = 44 years, 61% male, 82% moderate to severe ABI) were assessed at baseline (within two years post-injury), 3, 12, and 24 months using the Perth Alexithymia Questionnaire and the depression subscale of the Depression, Anxiety, Stress Scale. Bayesian latent growth models, and cross-lagged panel models were used to examine change, co-development, and directional relationships.Results: Mean alexithymia scores remained stable across timepoints, whereas depressive symptoms showed modest improvement. Both constructs exhibited moderate temporal stability, and were associated at baseline, demonstrating co-occurrence in early recovery. No consistent directional relationship was observed, and overall model fit was poor. Additionally, there was substantial missingness at 24 months (75%).Conclusion: These findings suggest that alexithymia is relatively stable in the first two years following ABI and commonly co-occurs with depressive symptoms early after injury. However, there is no clear longitudinal direction association. Early assessment of emotional processing and mood may help identify individuals at risk for ongoing psychological difficulties.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of transcranial Doppler and carotid ultrasound parameters with swallowing outcomes after endovascular thrombectomy for anterior circulation stroke. 经颅多普勒和颈动脉超声参数与前循环卒中血管内取栓术后吞咽结果的关系。

IF 1.5 4区医学

Brain injury Pub Date : 2026-09-02 DOI: 10.1080/02699052.2026.2725666

Hung-Hsi Lin, Shu-Mei Yang, Ting-Ju Lai, Yen-Heng Lin, Chueh-Hung Wu, Tyng-Guey Wang, Sung-Chun Tang, Meng-Ting Lin

{"title":"Association of transcranial Doppler and carotid ultrasound parameters with swallowing outcomes after endovascular thrombectomy for anterior circulation stroke.","authors":"Hung-Hsi Lin, Shu-Mei Yang, Ting-Ju Lai, Yen-Heng Lin, Chueh-Hung Wu, Tyng-Guey Wang, Sung-Chun Tang, Meng-Ting Lin","doi":"10.1080/02699052.2026.2725666","DOIUrl":"https://doi.org/10.1080/02699052.2026.2725666","url":null,"abstract":"Background: Post-stroke dysphagia (PSD) remains prevalent after anterior circulation stroke treated with endovascular thrombectomy (EVT). We evaluated associations between ultrasound-derived hemodynamic indices and swallowing outcomes and their incremental prognostic value beyond clinical factors.Methods: This retrospective cohort included 169 adults with anterior circulation stroke treated with EVT between November 2018 and November 2023. Transcranial Doppler and carotid ultrasonography measured intracranial pulsatility index (PI) and extracranial resistive index (RI). Outcomes included nasogastric (NG) tube dependence and Functional Oral Intake Scale (FOIS) at 4 and 12 weeks.Results: Several RI and PI measures were associated with swallowing outcomes in univariable analyses. Basilar artery (BA) PI showed a weak correlation with time to NG tube removal (r = 0.160, p = 0.044). After adjustment for age, initial National Institutes of Health Stroke Scale (NIHSS), and 3-step swallowing screening, BA PI was not significantly associated with NG tube dependence at 4 weeks or 12 weeks (p = 0.134 and p = 0.064) and did not improve model discrimination (DeLong p = 0.281 and p = 0.362).Conclusions: Ultrasound-derived hemodynamic parameters were associated with swallowing outcomes after EVT, but the incremental prognostic value of BA PI beyond clinical factors was limited and requires prospective validation.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-9"},"PeriodicalIF":1.5,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospective validation of a non-invasive bedside protocol for tracheostomy decannulation in acquired brain injury with otolaryngologic concordance. 一种无创床边治疗合并耳鼻喉疾病的获得性脑损伤气管切开术的前瞻性验证。

IF 1.5 4区医学

Brain injury Pub Date : 2026-08-26 DOI: 10.1080/02699052.2026.2720633

Sooraj Mavilakandy, Jacob George, Praveen Kumar Chinniah, Prashanth Chalageri, Madhavi Kandagaddala, Bindhu P Synthia

{"title":"Prospective validation of a non-invasive bedside protocol for tracheostomy decannulation in acquired brain injury with otolaryngologic concordance.","authors":"Sooraj Mavilakandy, Jacob George, Praveen Kumar Chinniah, Prashanth Chalageri, Madhavi Kandagaddala, Bindhu P Synthia","doi":"10.1080/02699052.2026.2720633","DOIUrl":"https://doi.org/10.1080/02699052.2026.2720633","url":null,"abstract":"Background: Decannulation of tracheostomy in individuals with acquired brain injury (ABI) is challenging and often requires endoscopic airway assessment. A reliable noninvasive bedside protocol could support decision-making in neurorehabilitation settings.Methods: We conducted a prospective observational cohort study at a tertiary neurorehabilitation center between July 2021 and March 2025. Thirty-six adults with chronic ABI and tracheostomies were assessed using a structured bedside protocol comprising tracheostomy capping tolerance, suction requirement ≤2 episodes per 24 hours, modified Evans blue dye aspiration screening, and laryngeal ultrasonography. All participants subsequently underwent blinded nasopharyngolaryngoscopic (NPL) examination as the reference standard.Results: Twenty-six participants (72.2%) were protocol positive; 24 were suitable for decannulation on NPL and two were unsuitable. Among 10 protocol-negative participants, nine were unsuitable and one was suitable. Sensitivity was 96.0% (95% CI 79.6-99.9), specificity 81.8% (95% CI 48.2-97.7), and overall accuracy 91.7%. Agreement with NPL findings was strong (κ = 0.80). No aspiration pneumonia, respiratory deterioration, or recannulation occurred during four weeks of follow-up.Conclusions: The bedside protocol may serve as a screening tool to support decannulation assessment and guide the need for confirmatory endoscopic evaluation. Larger multicentre studies are warranted.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148825219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resting-state EEG spectral power alterations following traumatic brain injury: a comprehensive systematic review and meta-analysis of clinical and injury-related moderators. 外伤性脑损伤后静息状态脑电图频谱功率改变：临床和损伤相关调节因子的综合系统回顾和荟萃分析。

IF 1.5 4区医学

Brain injury Pub Date : 2026-08-25 DOI: 10.1080/02699052.2026.2722231

Mark C Nwakamma, Emma M Tinney, Brooke M Ingemi, Charles H Hillman, Timothy P Morris

{"title":"Resting-state EEG spectral power alterations following traumatic brain injury: a comprehensive systematic review and meta-analysis of clinical and injury-related moderators.","authors":"Mark C Nwakamma, Emma M Tinney, Brooke M Ingemi, Charles H Hillman, Timothy P Morris","doi":"10.1080/02699052.2026.2722231","DOIUrl":"https://doi.org/10.1080/02699052.2026.2722231","url":null,"abstract":"Background: Traumatic brain injury (TBI) is a major global health concern associated with diverse neurophysiological alterations. Resting-state electroencephalography (rs-EEG) provides a noninvasive measure of post-injury neural oscillations, yet reported spectral power findings remain inconsistent, potentially due to differences in TBI etiology.Objective: We systematically reviewed and quantified rs-EEG spectral power changes following TBI and evaluated whether TBI etiology, time since injury, age, sex, and injury severity moderated these effects.Methods: Following PRISMA guidelines, we included case-control and longitudinal studies reporting rs-EEG spectral power metrics. Meta-regression models examined the influence of moderators.Results: Twenty-four studies (1,236 participants; 713 TBI, 523 controls) met inclusion criteria; 14 studies contributed 39 effect sizes to the meta-analysis. General TBI demonstrated more consistent slow-wave increases and fast-wave suppression than sport-related concussion (SRC). TBI was associated with increased theta power relative to controls (g = 0.50, p = 0.03), although substantial heterogeneity and publication bias were present. TBI etiology and sex moderated theta effects (p = 0.03, each), but neither remained significant after false discovery rate correction.Conclusion: TBI was associated with increased slow-wave activity, particularly theta power, although methodological heterogeneity warrants cautious interpretation. Standardized protocols and incorporation of aperiodic spectral metrics are needed to improve mechanistic understanding of post-injury brain dynamics.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-16"},"PeriodicalIF":1.5,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cathodal transcranial direct current stimulation for upper extremity functional rehabilitation in stroke survivors: a meta-analysis of parallel randomized controlled trials. 经颅阴极直流电刺激对中风幸存者上肢功能康复的影响：一项平行随机对照试验的荟萃分析。

IF 1.5 4区医学

Brain injury Pub Date : 2026-08-18 DOI: 10.1080/02699052.2026.2720336

Jiangmei Chen, Liqiang Yu, Fang Liu, Qiaoling Chen, Shuang Jin

{"title":"Cathodal transcranial direct current stimulation for upper extremity functional rehabilitation in stroke survivors: a meta-analysis of parallel randomized controlled trials.","authors":"Jiangmei Chen, Liqiang Yu, Fang Liu, Qiaoling Chen, Shuang Jin","doi":"10.1080/02699052.2026.2720336","DOIUrl":"https://doi.org/10.1080/02699052.2026.2720336","url":null,"abstract":"Background: Upper extremity motor dysfunction is common after stroke. Based on the inter-hemispheric inhibition model, cathodal transcranial direct current stimulation (c-tDCS) applied over the contralesional primary motor cortex (M1) is a promising adjuvant neuromodulation, but high-quality evidence for its efficacy, optimal parameters, and safety remains limited.Methods: We searched 10 databases through January 25, 2026, for parallel randomized controlled trials (RCTs). Methodological quality was assessed using Cochrane Risk of Bias 2.0, and meta-analyses were performed using RevMan 5.4 and Stata/SE 15.1.Results: Twenty-six RCTs (1038 patients) were included. Compared with controls, c-tDCS significantly improved upper extremity motor function, manual dexterity, and daily living activities, while also reducing elbow spasticity and overall neurological impairment (all p < 0.05). Resting motor threshold remained unchanged. Subgroup analyses showed stable efficacy at 1-2 mA, 20 min/session, 5 sessions/week, and ≥2 weeks of treatment. Short-term benefits were preserved, while long-term durability needs verification. Adverse events were mild and transient, mainly local tingling and itching.Conclusions: Adjuvant c-tDCS improves upper limb motor function, daily living activities, elbow spasticity, and global neurological status in stroke survivors, with favorable safety and short-term durability. A regimen of 1-2 mA for 20 min, 5 sessions/week for ≥2 weeks is recommended.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-15"},"PeriodicalIF":1.5,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential neuroprotective effects of resveratrol against traumatic brain injury in rodent models: a systematic review and meta-analysis. 白藜芦醇对啮齿动物创伤性脑损伤的潜在神经保护作用：一项系统综述和荟萃分析。

IF 1.5 4区医学

Brain injury Pub Date : 2026-08-17 DOI: 10.1080/02699052.2026.2717720

Mahrokh Janmohamadi, Amirreza Peyrovinasab, Arash Sarveazad, Niyousha Rahimimovaghar, Vafa Rahimi-Movaghar, Mahmoud Yousefifard

{"title":"Potential neuroprotective effects of resveratrol against traumatic brain injury in rodent models: a systematic review and meta-analysis.","authors":"Mahrokh Janmohamadi, Amirreza Peyrovinasab, Arash Sarveazad, Niyousha Rahimimovaghar, Vafa Rahimi-Movaghar, Mahmoud Yousefifard","doi":"10.1080/02699052.2026.2717720","DOIUrl":"https://doi.org/10.1080/02699052.2026.2717720","url":null,"abstract":"Background: Oxidative stress, inflammation, and apoptosis following traumatic brain injury (TBI) cause secondary damage that leads to long-term neurological impairments. Though its effectiveness in TBI remains largely underexplored, the natural polyphenol resveratrol (RES) shows neuroprotective effects. This meta-analysis assesses RES's therapeutic potential in rodent TBI models.Methods: Medline, Embase, Scopus, and Web of Science (up to April 2025) were searched for studies evaluating RES in rodent TBI using PRISMA recommendations. Inclusion criteria were satisfied by 10 studies. Outcomes included cerebral edema, autophagy, inflammation, apoptosis, neuronal density, and neurological status. With 95% confidence intervals, random-effects models computed standardized mean differences. We looked at publication bias (Egger's test) and heterogeneity (I2).Results: RES notably lowered autophagy markers (Beclin-1; LC3II) and cerebral edema. It decreased apoptosis (caspase-3) and inflammation (IL-1β; TNF-α). In CA1 and CA3 areas, hippocampal neuron density increased. With lower escape latency in the Morris water maze and Neurological Severity Score, memory and neurological status improved.Conclusion: By reducing edema, inflammation, and apoptosis, RES shows strong neuroprotection in rodent TBI models while maintaining neurons and improving recovery. RES is a reasonable contender for supplementary TBI treatment.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-13"},"PeriodicalIF":1.5,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurostimulant use to facilitate recovery after traumatic brain injury in an adolescent patient with preexisting ADHD: a case report. 神经兴奋剂的使用，以促进恢复创伤性脑损伤后的青少年患者先前存在的注意力缺陷多动障碍：一个案例报告。

IF 1.5 4区医学

Brain injury Pub Date : 2026-08-10 DOI: 10.1080/02699052.2026.2715504

Samantha N Koerber, Andrea Zuzarte, Neha Anand, Jaimie Hearn, Kilby Mann

{"title":"Neurostimulant use to facilitate recovery after traumatic brain injury in an adolescent patient with preexisting ADHD: a case report.","authors":"Samantha N Koerber, Andrea Zuzarte, Neha Anand, Jaimie Hearn, Kilby Mann","doi":"10.1080/02699052.2026.2715504","DOIUrl":"https://doi.org/10.1080/02699052.2026.2715504","url":null,"abstract":"Background: Neurostimulants are commonly used after traumatic brain injury (TBI) to improve arousal, attention, and participation in rehabilitation. However, little is known about stimulant use among pediatric patients with preexisting attention-deficit/hyperactivity disorder (ADHD). We describe stimulant use to facilitate emergence from post-traumatic amnesia (PTA) in an adolescent with severe TBI and preexisting ADHD.Case presentation: A 14-year-old male with ADHD sustained a severe TBI with diffuse axonal injury following an electric scooter crash. He experienced prolonged PTA, severe agitation, and motor restlessness despite multimodal pharmacologic management and environmental interventions. On post-injury day 17, a trial of methylphenidate produced rapid improvements in attention and agitation. Agitated Behavior Scale scores subsequently decreased, and he emerged from PTA by post-injury day 23.Discussion: This case highlights a potential role for individualized neurostimulant therapy in facilitating recovery after severe TBI among adolescents with preexisting ADHD. To our knowledge, this is the first pediatric case in the literature describing stimulant use to facilitate emergence from PTA in a patient with preexisting ADHD. Further research is needed to establish evidence-based guidance for stimulant selection, dosing, and timing of re-initiation after pediatric TBI.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-3"},"PeriodicalIF":1.5,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A scoping review of therapies to support marriages and partnerships after acquired brain injury. 获得性脑损伤后支持婚姻和伙伴关系的治疗方法的范围审查。

IF 1.5 4区医学

Brain injury Pub Date : 2026-08-06 DOI: 10.1080/02699052.2026.2713030

Gerard A Riley, Urszula Gajewska

{"title":"A scoping review of therapies to support marriages and partnerships after acquired brain injury.","authors":"Gerard A Riley, Urszula Gajewska","doi":"10.1080/02699052.2026.2713030","DOIUrl":"https://doi.org/10.1080/02699052.2026.2713030","url":null,"abstract":"Background: Acquired brain injury (ABI) can undermine marriages/partnerships. Couples need access to relationship therapies proven to be effective in a brain injury context.Objective: To provide an overview of relationship therapies evaluated for use in ABI.Methods: Six databases were searched for studies that evaluated the impact on the relationship of interventions that were, at least partly, intended to improve the relationship.Results: Twenty-seven papers were included. Some reported the use of therapies widely used with other populations (family therapy, emotion-focused therapy, behavioral couples therapy). Others involved a structured curriculum specifically designed for use with couples living with ABI and focused on education and skills training. Most therapies also addressed non-relational issues. Couples tended to be middle-aged, White, and heterosexual. Studies generally used weak designs, and there were only six randomized controlled trials. Of 24 outcomes reported by these RCTs, all but three were classed as showing no effect or small improvement.Conclusions: Therapies would benefit from further development to ensure better outcomes, in part by ensuring that sufficient therapeutic time is allocated and that all the relational issues of concern to the couple are addressed. More inclusive samples and stronger designs would also help.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-22"},"PeriodicalIF":1.5,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered Temporal dynamics of resting-state EEG microstates as a neural signature of impaired consciousness: a high-density EEG analysis in chronic disorders of consciousness. 静息状态脑电图微态的时间动态变化作为意识受损的神经特征：慢性意识障碍的高密度脑电图分析。

IF 1.5 4区医学

Brain injury Pub Date : 2026-08-05 DOI: 10.1080/02699052.2026.2707614

Xu Dong, Dan Wang, Jiajia Hou, Peipei Wang, Xue Jian, Tao Feng

{"title":"Altered Temporal dynamics of resting-state EEG microstates as a neural signature of impaired consciousness: a high-density EEG analysis in chronic disorders of consciousness.","authors":"Xu Dong, Dan Wang, Jiajia Hou, Peipei Wang, Xue Jian, Tao Feng","doi":"10.1080/02699052.2026.2707614","DOIUrl":"https://doi.org/10.1080/02699052.2026.2707614","url":null,"abstract":"Primary objective: To differentiate Unresponsive Wakefulness Syndrome (UWS) from Minimally Conscious State (MCS) using EEG microstates.Research design: Retrospective analysis of high-density resting-state EEG.Methods and procedures: We analyzed EEG from 20 UWS, 22 MCS patients, and 20 controls. Microstate topographies were clustered into four canonical classes. To prevent machine learning data leakage, a fixed, label-independent template basis derived solely from healthy controls was utilized for back-fitting across all individuals. After optimizing template back-fitting and systematically controlling for group-dependent spatial map distortions via class-specific spatial correlation (SC) analysis, robust temporal parameters were extracted. A strictly contained Leave-One-Subject-Out Cross-Validation (LOOCV) multivariate logistic regression model was then applied.Main outcomes and results: Class D coverage progressively degraded (HC > MCS > UWS; p < 0.001) and correlated robustly with Coma Recovery Scale-Revised scores (ρ =0.84). Class C paradoxically increased in UWS. The multivariate LOOCV model accurately distinguished MCS from UWS (AUC = 0.97).Conclusions: The selective collapse of Class D alongside Class C retention signifies severe frontoparietal decoupling. Cross-validated microstate dynamics serve as specific bedside biomarkers for prognostic stratification, empirically supporting the Global Neuronal Workspace and Mesocircuit hypotheses.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of protocol-driven care with complication rates in severe traumatic brain injury: a two-hospital quasi-experimental study in a resource-limited setting. 重度创伤性脑损伤方案驱动型护理与并发症发生率的关联：一项资源有限环境下两家医院的准实验研究

IF 1.5 4区医学

Brain injury Pub Date : 2026-08-02 DOI: 10.1080/02699052.2026.2710725

Jalil I Hussein, Younus Khudhur Baeez

{"title":"Association of protocol-driven care with complication rates in severe traumatic brain injury: a two-hospital quasi-experimental study in a resource-limited setting.","authors":"Jalil I Hussein, Younus Khudhur Baeez","doi":"10.1080/02699052.2026.2710725","DOIUrl":"https://doi.org/10.1080/02699052.2026.2710725","url":null,"abstract":"Objective: To evaluate the impact of implementing Brain Trauma Foundation (BTF) guidelines on complication rates and clinical outcomes in severe traumatic brain injury (STBI) in a resource-limited setting.Methods: A quasi-experimental study (n = 70) was conducted in a resource-limited setting. Control group (n = 35) received routine care; study group (n = 35) was managed according to BTF guidelines. Complications (fever, pressure ulcers, hyperglycemia, infection, increased ICP) were collected daily. Outcomes included complication rates/severity, ventilation days, ICU stay, and Glasgow Outcome Scale Extended (GOSE).Results: The study group had significantly lower complication rates: fever (37.1% vs. 62.9%, p = 0.055), bed sores (5.7% vs. 31.4%, p = 0.0065), hyperglycemia (31.4% vs. 57.1%, p = 0.05), infection (20.0% vs. 51.4%, p = 0.01), and increased ICP (11.4% vs. 42.9%, p = 0.006). Mean complications per patient were lower (1.9 ± 1.2 vs. 2.8 ± 1.5, p = 0.006). Early surgery (48-72 h) was associated with lower complication rates. Complication occurrence strongly predicted unfavorable outcomes.Conclusions: Implementing BTF guidelines was associated with lower complication incidence and severity in STBI patients in a resource-limited setting. Protocol-driven care and early surgery were associated with fewer complications, which strongly predicted better functional outcomes.However, because the intervention and control groups were treated at different hospitals with differing resources, these findings should be interpreted as hypothesis-generating rather than causal.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0