Brain injury最新文献

Effect of tactile stimulation in disorders of consciousness: a systematic review. 触觉刺激在意识障碍中的作用：系统综述。

IF 1.8 4区医学

Brain injury Pub Date : 2026-05-08 DOI: 10.1080/02699052.2026.2668111

Simona Abagnale, Alfonso Magliacano, Francesco Panico, Laura Sagliano, Konstantina Kilteni, Anna Estraneo, Olivia Gosseries, Luigi Trojano

{"title":"Effect of tactile stimulation in disorders of consciousness: a systematic review.","authors":"Simona Abagnale, Alfonso Magliacano, Francesco Panico, Laura Sagliano, Konstantina Kilteni, Anna Estraneo, Olivia Gosseries, Luigi Trojano","doi":"10.1080/02699052.2026.2668111","DOIUrl":"https://doi.org/10.1080/02699052.2026.2668111","url":null,"abstract":"Background: Disorders of consciousness (DoC) represent a major challenge in neurorehabilitation. Sensory stimulation, particularly tactile stimulation, has been proposed as a therapeutic intervention to enhance arousal and awareness in these patients.Objective: This systematic review aimed to evaluate the effectiveness of tactile stimulation interventions in patients with DoC.Methods: A systematic search of the literature identified 25 studies published between 1989 and 2025 investigating tactile stimulation in these patients. Data were extracted on the types of tactile interventions, methodologies, frequency, duration, and outcomes.Results: Tactile stimulation was most commonly delivered through massage, brushing, or textured contact, targeting areas, such as the hands, arms, and face. Interventions were typically brief, administered daily over short periods, and often embedded within multimodal rehabilitation programmes. Across studies, tactile stimulation was associated with short-term improvements in behavioral indicators of consciousness and physiological responses, including heart rate and electroencephalographic activity. Interventions administered by family members appeared to yield particularly robust effects, highlighting the affective dimension of touch.Conclusions: Current evidence supports the short-term benefits of tactile stimulation in DoC, while long-term effects remain insufficiently investigated. Future research should prioritize standardized, patient-centered protocols, with systematic follow-up and evaluation of single versus multimodal approaches, including family involvement.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-16"},"PeriodicalIF":1.8,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physiotherapy-based concussion management outcomes are similar for children whether care is provided in-person or via telehealth. 基于物理治疗的脑震荡管理结果对于儿童来说是相似的，无论护理是亲自提供还是通过远程医疗提供。

IF 1.8 4区医学

Brain injury Pub Date : 2026-05-07 DOI: 10.1080/02699052.2026.2669601

Camille Doucet, Isabelle J Gagnon, Christine Beaulieu, Lisa Grilli, Elizabeth F Teel

{"title":"Physiotherapy-based concussion management outcomes are similar for children whether care is provided in-person or via telehealth.","authors":"Camille Doucet, Isabelle J Gagnon, Christine Beaulieu, Lisa Grilli, Elizabeth F Teel","doi":"10.1080/02699052.2026.2669601","DOIUrl":"https://doi.org/10.1080/02699052.2026.2669601","url":null,"abstract":"Objective: To determine if physiotherapy outcomes differ in children with concussion treated in-clinic versus virtually.Methods: Licensed physiotherapists assessed and treated 23 children with concussion using telehealth delivery during COVID-19. These patients were matched to children assessed and treated in-clinic before (n = 23) and during (n = 23) the COVID-19 pandemic (total sample mean age = 13.5 ± 3.0 years, 65.2% girls). Physiotherapy examination findings, rehabilitation prescription outcomes, and total recovery time were analyzed using Cochran's Q test, Friedman's tests, linear mixed-effects models, or frailty models.Results: Missed balance (p < 0.001) and vestibular/visual (p = 0.008) assessments were more frequent in the telehealth group, but no differences were observed for completed assessments (p > 0.05). All participants were given low-to-moderate intensity aerobic exercise recommendations, with coordination (n = 42), vestibular/visual (n = 31), and cervical spine (n = 11) therapies also prescribed. For recovery outcomes, neither the in-clinic (COVID, HR: 0.88, 95% CI: 0.41-1.88, p = 0.74) or telehealth (HR: 0.60, 95% CI: 0.27-1.31, p = 0.20) groups differed from the in-clinic (pre) reference group.Conclusion: Telehealth delivery produces largely similar outcomes as in-person care, although select assessments cannot be delivered virtually. Telehealth care, particularly hybrid formats, should be further explored for pediatric concussion management.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-9"},"PeriodicalIF":1.8,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment-seeking and perceived helpfulness among individuals with persistent post-concussion symptoms. 持续性脑震荡后症状患者的治疗寻求和感知帮助

IF 1.8 4区医学

Brain injury Pub Date : 2026-04-20 DOI: 10.1080/02699052.2026.2657930

Amanda Rabinowitz, Lauren Krasucki, McKenzie Buszkiewic, Allie J Tracey

{"title":"Treatment-seeking and perceived helpfulness among individuals with persistent post-concussion symptoms.","authors":"Amanda Rabinowitz, Lauren Krasucki, McKenzie Buszkiewic, Allie J Tracey","doi":"10.1080/02699052.2026.2657930","DOIUrl":"10.1080/02699052.2026.2657930","url":null,"abstract":"Objective: To characterize treatment utilization and perceived helpfulness among individuals with persistent post-concussion symptoms (PPCS) during the first year post-injury and explore whether treatment engagement was associated with symptom change over time.Materials & methods: We enrolled 40 individuals (62.5% female; mean age = 43.0 ± 11.5 years) in our prospective observational study. Participants completed an initial visit and 3-month follow-up. At each visit, participants reported symptoms via the Post-Concussion Symptom Scale (PCSS) and the number and type of treatments they received, and rated the helpfulness of each treatment. One participant was lost to follow-up.Results: Most (83%) participants received one or more treatments, most commonly medication and psychotherapy. Across all treatments reported, many participants endorsed them as helpful (range: 71.4%-100%). Participants reported high initial visit symptom burden, regardless of treatment involvement (M = 57.4 ± 23.7), with a significant mean improvement of 13.8 points at follow-up (t(38) = 4.53, p < 0.001). Symptom change over time (i.e., from the initial visit to follow-up) was not significantly associated with whether participants were involved in treatment (β = 4.23, t(41.42) = 0.53, p = 0.598) or with the number of treatments participants received (β = 0.71, t(39.82) = 0.43, p = 0.671).Conclusions: Individuals with PPCS pursue diverse, often multimodal treatments and perceive them as helpful, yet many continue to experience substantial symptoms. Findings underscore the need for coordinated, evidence-informed care and greater precision in specifying active treatment components in PPCS rehabilitation.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-6"},"PeriodicalIF":1.8,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of cognitive-vocational rehabilitation on post-concussion symptoms and emotional distress: a secondary RCT analysis. 认知-职业康复对脑震荡后症状和情绪困扰的影响：一项二次RCT分析。

IF 1.8 4区医学

Brain injury Pub Date : 2026-04-19 DOI: 10.1080/02699052.2026.2654829

Nada Andelic, Juan Lu, Silje C R Fure, Cathrine Brunborg, Marianne Løvstad, Cecilie Røe, Emilie Isager Howe

{"title":"Effects of cognitive-vocational rehabilitation on post-concussion symptoms and emotional distress: a secondary RCT analysis.","authors":"Nada Andelic, Juan Lu, Silje C R Fure, Cathrine Brunborg, Marianne Løvstad, Cecilie Røe, Emilie Isager Howe","doi":"10.1080/02699052.2026.2654829","DOIUrl":"https://doi.org/10.1080/02699052.2026.2654829","url":null,"abstract":"Objective: To examine the long-term effects of a combined Compensatory Cognitive Training and Supported Employment (CCT-SE) intervention on post-concussion symptoms (PCS) and emotional distress in individuals with mild-to-moderate traumatic brain injury (TBI) on sick leave 8-12 weeks post-injury.Methods: In this secondary analysis of a randomized controlled trial at Oslo University Hospital, 116 working-age adults were randomized to CCT-SE or treatment as usual (TAU). CCT-SE consisted of a 10-week cognitive rehabilitation program and up to 6 months of individualized vocational support. Outcomes included PCS (Rivermead Post-Concussion Symptoms Questionnaire, RPQ), depression (PHQ-9), and anxiety (GAD-7), assessed at 3, 6, and 12 months. Linear mixed-effects models evaluated group differences over time.Results: At baseline, participants reported a moderate-to-severe PCS burden (mean RPQ 28, SD 11); 38% had moderate-to-severe depressive symptoms and 17% moderate-to-severe anxiety. The CCT-SE group showed significantly greater improvement in RPQ cognitive scores at 12 months versus TAU. No between-group differences were found for PHQ-9, GAD-7, or RPQ somatic and emotional subscales, though both groups demonstrated significant within-group improvement across all outcomes.Conclusions: Early cognitive and vocational rehabilitation may benefit individuals with persistent cognitive symptoms after mild-to-moderate TBI. Given the prevalence of emotional distress, integrating psychological interventions may strengthen CCT-SE.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-8"},"PeriodicalIF":1.8,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Individual placement and support for people with acquired brain injury: feasibility and initial results. 获得性脑损伤患者的个体安置和支持：可行性和初步结果。

IF 1.8 4区医学

Brain injury Pub Date : 2026-04-14 DOI: 10.1080/02699052.2026.2654830

Judith M van Velzen, Judith M Mollet, Coen A M van Bennekom, Angela G E M de Boer

{"title":"Individual placement and support for people with acquired brain injury: feasibility and initial results.","authors":"Judith M van Velzen, Judith M Mollet, Coen A M van Bennekom, Angela G E M de Boer","doi":"10.1080/02699052.2026.2654830","DOIUrl":"https://doi.org/10.1080/02699052.2026.2654830","url":null,"abstract":"Purpose: To examine the feasibility of the Individual Placement and Support (IPS-)intervention for people with acquired brain injury (ABI) in the chronic phase without an employer and explore initial outcomes.Methods: A feasibility study was conducted in three Dutch institutions specialized in post-ABI work participation. Participants included five IPS employment specialists (IPS-ES), 15 clients with ABI, 13 relatives, and eight employers. Clients' IPS-counseling lasted 1 year. Data were collected through questionnaires, IPS-ES administration, and researcher-administered home assessments. Feasibility was evaluated in terms of acceptability, implementation, practicality, adaptation, and limited-efficacy testing using descriptive analyses.Results: Acceptability analyses showed median scores of 7, 8, 7, and 7 points across groups for counseling, and 8, 7, 6, and 7 points for counseling outcomes (scale 1 (not) - 10 (very satisfied)). Implementation showed reasonable model fidelity, with strengths in IPS-ES guidance and expertise, and challenges in competitive employment focus, rapid job search and placement, and integration of health and employment services. Practicality was sufficient. Several adaptations were suggested. Limited-efficacy testing showed eight of 15 clients (53%) obtaining paid work.Conclusion: IPS appeared feasible: Implementation was reasonably model-faithful, stakeholders were satisfied, and >50% achieved paid employment. Broader implementation is recommended, addressing identified challenges and continuing evaluation.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-12"},"PeriodicalIF":1.8,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A closed-head, rotational traumatic brain injury model demonstrates deficits in righting reflex, neurological function, and auditory brainstem responses in rats. 闭头、旋转创伤性脑损伤模型显示了大鼠的翻正反射、神经功能和听觉脑干反应的缺陷。

IF 1.8 4区医学

Brain injury Pub Date : 2026-04-10 DOI: 10.1080/02699052.2026.2654216

Michelle L Bordas, Grant D Broeckel, Katherine Sherman, Alok Shah, Matthew D Budde, Christina L Runge, Brian D Stemper, Christopher J Roberts

{"title":"A closed-head, rotational traumatic brain injury model demonstrates deficits in righting reflex, neurological function, and auditory brainstem responses in rats.","authors":"Michelle L Bordas, Grant D Broeckel, Katherine Sherman, Alok Shah, Matthew D Budde, Christina L Runge, Brian D Stemper, Christopher J Roberts","doi":"10.1080/02699052.2026.2654216","DOIUrl":"10.1080/02699052.2026.2654216","url":null,"abstract":"Aims: The pathophysiology of traumatic brain injury (TBI) is incompletely understood and warrants further investigation with preclinical models that recapitulate aspects of the human condition. Therefore, our goal was to quantify the initial presentation of deficits in a closed-head rotational TBI model in male and female rats in return of righting reflex (RORR) and global neurological function including gross sound reflex scores as a measure of acoustic startle.Methods: A total of 116 rats (43 female) were included in this study that underwent TBI (n = 53), Sham (n = 42), or No Anesthesia control (n = 21) procedures to assess RORR, the Revised Neurobehavioral Severity Scale (NSS-R), or Auditory Brainstem Responses (ABR).Results: TBI rats had a trend toward a prolonged RORR, which was significantly increased in the TBI compared to control group when normalized to the duration of anesthesia. Gross neurological function was impaired in TBI rats, such that descriptively the largest component was due to acoustic startle deficits. These deficits were not explained by worse (higher) hearing thresholds in auditory brainstem responses, although TBI rats had increased thresholds at 16 and 20 kHz, and a trend at 10 kHz compared to Shams on post-TBI day 1 that was not different by day 8.Conclusions: This model reproduces acoustic startle, and hearing impairment aspects of human TBI that influence quality of life. Additional studies are necessary to integrate variables from new clinical classification systems including blood-based and imaging biomarkers to aid in the translation to improve patient-oriented outcomes.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-13"},"PeriodicalIF":1.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progranulin alleviates cerebral ischemia-reperfusion-induced neuronal ferroptosis via regulating p-STAT3/HSPA5 signaling. 前颗粒蛋白通过调节p-STAT3/HSPA5信号通路减轻脑缺血再灌注诱导的神经元铁下垂。

IF 1.8 4区医学

Brain injury Pub Date : 2026-04-10 DOI: 10.1080/02699052.2026.2638957

Guilong Su, Binru Li, Wanxing Lu, Zhengxiang Huang, Weidong Nong, Chun Luo

{"title":"Progranulin alleviates cerebral ischemia-reperfusion-induced neuronal ferroptosis via regulating p-STAT3/HSPA5 signaling.","authors":"Guilong Su, Binru Li, Wanxing Lu, Zhengxiang Huang, Weidong Nong, Chun Luo","doi":"10.1080/02699052.2026.2638957","DOIUrl":"https://doi.org/10.1080/02699052.2026.2638957","url":null,"abstract":"Introduction: Progranulin (PGRN) exerts neuroprotective effects. However, the roles of PGRN in cerebral ischemia/reperfusion (I/R) injury have not been reported.Objective: This study aimed to investigate the potentials of PGRN in cerebral ischemia injury.Methods: Middle cerebral artery occlusion/reperfusion (MCAO/R) surgery was used to establish mouse cerebral ischemia/reperfusion (I/R) injury model. Neuronal loss was detected using terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay. HT22 cells were exposed to oxygen-glucose deprivation/reoxygenation to establish an in vitro cerebral I/R model. Gene expression was detected using reverse transcription-quantitative PCR, immunofluorescence, and Western blot. Oxidative stress was detected using reactive oxygen species and malondialdehyde assays. Iron metabolism was detected using ferrous iron assay. Neuronal functions were determined using Cell Counting Kit-8 and propidium iodide staining assay. Signal transducer and activator of transcription 3 (STAT3) and heat shock protein family A member 5 (HSPA5) interaction was determined using dual-luciferase reporter and chromatin immunoprecipitation assays.Results: Cerebral I/R injury contributed to neuronal ferroptosis. PGRN was downregulated in cerebral I/R injury in vivo and in vitro, the overexpression of which inhibited oxidative stress and neuronal ferroptosis. PGRN promoted the hyperactivation of STAT3, which transcriptionally upregulated HSPA5 signaling. However, STAT3 knockdown abolished the effects of PGRN overexpression and promoted oxidative stress and neuronal ferroptosis.Conclusions: In summary, PGRN protected neurons from the cerebral I/R injury-induced ferroptosis via activating p-STAT3/HSPA5 signaling. Therefore, PGRN may be a therapeutic target for cerebral I/R injury.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-12"},"PeriodicalIF":1.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traumatic brain injury-related stigma among intimate partner violence survivors. 亲密伴侣暴力幸存者中与创伤性脑损伤相关的污名。

IF 1.8 4区医学

Brain injury Pub Date : 2026-04-06 DOI: 10.1080/02699052.2026.2649542

Sofia Fauza, Margarita Velasco, Eve Valera, Altaf Saadi

{"title":"Traumatic brain injury-related stigma among intimate partner violence survivors.","authors":"Sofia Fauza, Margarita Velasco, Eve Valera, Altaf Saadi","doi":"10.1080/02699052.2026.2649542","DOIUrl":"10.1080/02699052.2026.2649542","url":null,"abstract":"Objective: Traumatic brain injury (TBI) is common among survivors of intimate partner violence (IPV), yet little is known about TBI-related stigma in this population. This qualitative study explores how such stigma affects IPV survivors, building on broader research showing its impact on recovery.Methods: We conducted individual interviews with IPV survivors with TBI. We analyzed the data using hybrid inductive-deductive thematic analysis.Results: We interviewed 20 women (mean age = 44 years, SD: 8.7, range 31-60), including 14 English speakers and 6 Spanish speakers. The largest subgroup (n = 7, 35%) had sustained four TBI's. We identified seven themes spanning three levels: A) Societal, B) Interpersonal, and C) Intrapersonal. At the societal level, the themes were: 1) Stigma across sectors, not limited to healthcare, and 2) Overlapping stigmas with mental health challenges. At the interpersonal level: 3) Interpersonal conflict due to negative attitudes and behaviors, and 4) Lack of understanding about TBI and symptoms. At the intrapersonal level: 5) TBI-related symptoms contributing to shame and self-discrepancy, and 6) Challenges with acceptance of TBI. The final theme cut across all levels: 7) Validation of experience as critical to post-TBI recovery.Conclusion: To support IPV survivors with TBI, practitioners must address and reduce stigma.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-10"},"PeriodicalIF":1.8,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinician perspectives on determinants for assessing and treating intimate partner violence-related traumatic brain injury: a mixed methods content analysis. 临床医生对评估和治疗亲密伴侣暴力相关创伤性脑损伤的决定因素的观点：混合方法内容分析。

IF 1.8 4区医学

Brain injury Pub Date : 2026-04-01 Epub Date: 2026-02-18 DOI: 10.1080/02699052.2026.2626015

Librada Callender, Christa Ochoa, Alexandria Suhalka, Simon Driver, Paul J Rowan, Jose-Miguel Yamal, Bridget Cotner, Enrico Quilico, Randi Dubiel, Katelyn Jetelina

{"title":"Clinician perspectives on determinants for assessing and treating intimate partner violence-related traumatic brain injury: a mixed methods content analysis.","authors":"Librada Callender, Christa Ochoa, Alexandria Suhalka, Simon Driver, Paul J Rowan, Jose-Miguel Yamal, Bridget Cotner, Enrico Quilico, Randi Dubiel, Katelyn Jetelina","doi":"10.1080/02699052.2026.2626015","DOIUrl":"10.1080/02699052.2026.2626015","url":null,"abstract":"Introduction: Intimate partner violence (IPV)-related traumatic brain injury (TBI) is understudied and underrecognized. Missed opportunities for managing IPV-TBI in the clinical setting leave survivors at risk for repeated injury and reduced access to care for cognitive and psychosocial repercussions. The objective of this study was to describe clinician perspectives with screening and managing IPV-related TBI in the clinical setting.Materials and methods: Clinicians across the United States completed an online, cross-sectional survey regarding their perspectives on IPV-related TBI. Likert-scale questions were summarized, and open-text responses were analyzed using qualitative content analysis.Results: Respondents (n = 60) were primarily physicians (38%) or nurses (42%) working in emergency (52%), trauma (52%), and rehabilitation (30%). Most (73%) agreed that IPV-related TBI was difficult to diagnose, reported no training/education on identification (63%) or treatment (67%), and were not aware of organizational (53%) or state/federal policies (48%). Content analysis revealed challenges, facilitators, and recommendations with the following higher order themes: 'Education and Training,' 'Clinical Practice,' and 'Policy.'Discussion: Standardizing education and training across clinical disciplines and specialties may improve routine screening for IPV-related TBI, resulting in improved access to care pathways and enhanced treatment approaches.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"493-513"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic ability of salivary S100B in predicting unfavorable outcomes in patients with moderate and severe traumatic brain injury. 唾液S100B在预测中重度颅脑损伤患者不良结局中的预后能力。

IF 1.8 4区医学

Brain injury Pub Date : 2026-04-01 Epub Date: 2026-02-07 DOI: 10.1080/02699052.2026.2625373

Lillian Caroline Fernandes, Dyenily Alessi Sloboda, Lilia de Souza Nogueira, Wellingson Silva Paiva, Leda Leme Talib, Cicero Augusto Costa Pereira, Augusto Magno Tranquezi Cordeiro, Regina Marcia Cardoso de Sousa

{"title":"Prognostic ability of salivary S100B in predicting unfavorable outcomes in patients with moderate and severe traumatic brain injury.","authors":"Lillian Caroline Fernandes, Dyenily Alessi Sloboda, Lilia de Souza Nogueira, Wellingson Silva Paiva, Leda Leme Talib, Cicero Augusto Costa Pereira, Augusto Magno Tranquezi Cordeiro, Regina Marcia Cardoso de Sousa","doi":"10.1080/02699052.2026.2625373","DOIUrl":"10.1080/02699052.2026.2625373","url":null,"abstract":"Introduction: S100B is the most studied biomarker for prognosis of traumatic brain injury (TBI), and saliva is a promising matrix. This study evaluated the prognostic value of S100B in saliva and plasma after moderate to severe traumatic brain injury (TBI).Methods: A prospective cohort included 25 adult patients (18-60 years) admitted to three hospitals with a Glasgow Coma Scale score of 3 to 12 within four hours post-trauma. Saliva and plasma samples were collected three hours after the trauma, with an additional saliva sample collected at six hours. Outcomes were assessed using the Glasgow Outcome Scale at discharge and its extended version.Results: Plasma S100B levels were higher than salivary (p = 0.0113) and decreased significantly between 3 and 6 hours (p < 0.0001). Salivary S100B at 6 hours was significantly higher in patients with unfavorable outcomes (p = 0.0248). Among all measures, salivary S100B at 6 hours demonstrated the highest prognostic accuracy, with an area under the curve (AUC). AUC for salivary S100B was 0.71 at 3 hours and 0.62 at 3 months, compared to 0.66 for plasma.Conclusion: Salivary S100B at 6 hours post-TBI showed superior prognostic performance compared to plasma and earlier saliva samples, highlighting its potential as a noninvasive biomarker for TBI prognosis.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"480-492"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0