Brain injury最新文献

Exosomes beyond stem cells during traumatic brain injury: hype or hope? 外伤性脑损伤中干细胞外泌体：炒作还是希望？

IF 1.5 4区医学

Brain injury Pub Date : 2025-06-10 DOI: 10.1080/02699052.2025.2489592

Mehrdad Hajinejad, Mahsa Abedi, Sajad Sahab Negah

{"title":"Exosomes beyond stem cells during traumatic brain injury: hype or hope?","authors":"Mehrdad Hajinejad, Mahsa Abedi, Sajad Sahab Negah","doi":"10.1080/02699052.2025.2489592","DOIUrl":"https://doi.org/10.1080/02699052.2025.2489592","url":null,"abstract":"Background: Based on the available data, stem cell therapy is a hopeful cure option for neurotrauma, especially traumatic brain injury. Stem cells can improve neurological outcomes and promote neuroregeneration after an injury through mechanisms such as bystander effects, cell replacement, and the activation of endogenous pathways. However, several uncertainties and limitations exist in achieving appropriate results and applying stem cell therapy at the clinical level. This study performed an extensive review of a pertinent database, utilizing targeted keywords to extract information regarding the application of stem cells and their exosomes in the context of brain injury. It also examined the distinctions between these two modalities in therapeutic strategies.Results: Recent research has demonstrated that exosomes, which are small extracellular vesicles, can overwhelm boundaries associated with stem cell therapy, such as issues with bioavailability and immune responses. A comprehensive review article is needed to discuss the benefits and drawbacks of using stem cell products, including exosomes, for treating traumatic brain injury (TBI).Conclusion: Therefore, exosome therapy has garnered significant attention in stem cell-based therapy for brain injuries. However, further research is needed to explore its mechanisms.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-12"},"PeriodicalIF":1.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

15th world congress on brain injury abstracts. 第十五届世界脑损伤大会摘要。

IF 1.5 4区医学

Brain injury Pub Date : 2025-06-07 DOI: 10.1080/02699052.2025.2509453

引用次数: 0

Progress in hyperbaric oxygen therapy for neonatal hypoxic-ischemic encephalopathy: mechanisms and combination therapies. 高压氧治疗新生儿缺氧缺血性脑病的进展：机制和联合治疗。

IF 1.5 4区医学

Brain injury Pub Date : 2025-06-05 DOI: 10.1080/02699052.2025.2514158

Xinyi Liu, Shuyue Deng, Lan Kang

{"title":"Progress in hyperbaric oxygen therapy for neonatal hypoxic-ischemic encephalopathy: mechanisms and combination therapies.","authors":"Xinyi Liu, Shuyue Deng, Lan Kang","doi":"10.1080/02699052.2025.2514158","DOIUrl":"https://doi.org/10.1080/02699052.2025.2514158","url":null,"abstract":"Purpose of research: This review explores the therapeutic potential of hyperbaric oxygen therapy (HBOT) in treating neonatal hypoxic-ischemic encephalopathy (HIE), focusing on its mechanisms of action, combination strategies, and current research gaps.Principal results: HBOT enhances neuroprotection by increasing arterial oxygen content, promoting neural tissue repair, modulating gene expression, and reducing oxidative stress. When combined with therapies such as therapeutic hypothermia, neurotrophic agents, antioxidants, or phenobarbital, HBOT exhibits synergistic effects. Clinical studies have demonstrated superior outcomes with HBOT-hypothermia combinations versus monotherapies. However, current literature lacks stratified analyses based on HIE severity, head-to-head comparisons of combination strategies, and long-term follow-up data. Moreover, most existing reviews focus solely on mechanisms, underrepresenting clinical applications.Conclusions: HBOT holds promise as a non-invasive adjunct therapy for neonatal HIE, especially in combination with established treatments. Its safety has improved with advances in neonatal care, allowing broader clinical use. Nonetheless, standardized protocols, stratified clinical trials, and molecular-level studies are needed to optimize therapeutic strategies and enhance outcomes in affected infants.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-9"},"PeriodicalIF":1.5,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive functioning following mild stroke in adults aged 18 to 64 years: association with participation. 18至64岁成人轻度中风后的认知功能：与参与的关系

IF 1.5 4区医学

Brain injury Pub Date : 2025-06-03 DOI: 10.1080/02699052.2025.2513616

Laurie Dubois, Bénédicte Dussault, Alexandra Ribon-Demars, Valérie Poulin, Marie-Christine Ouellet, Simon Beaulieu-Bonneau

{"title":"Cognitive functioning following mild stroke in adults aged 18 to 64 years: association with participation.","authors":"Laurie Dubois, Bénédicte Dussault, Alexandra Ribon-Demars, Valérie Poulin, Marie-Christine Ouellet, Simon Beaulieu-Bonneau","doi":"10.1080/02699052.2025.2513616","DOIUrl":"https://doi.org/10.1080/02699052.2025.2513616","url":null,"abstract":"Objectives: This cross-sectional study aims to describe objective and subjective cognitive functioning and to explore the relationship between cognition, participation, fatigue, and psychological symptoms, in adults aged 18-64 with mild stroke.Methods: Fifty-seven adults (mean age = 52 years; 51% women) who were hospitalized after a mild stroke were recruited. They completed a short telephone cognitive assessment and online questionnaires on average six months after stroke (range: 3-13).Results: Results suggest that mean scores of cognitive tests fell within the average normative range, although an underestimation of cognitive impairment cannot be ruled out. Moreover, compared to a normal distribution, a greater proportion of participants had average or below average cognitive performances. The most common subjective cognitive complaints were mental slowness (54% of sample), memory difficulties (51%), concentration difficulties 51%), and multitasking (47%). Objective cognitive performance was not associated with subjective cognitive complaints. Subjective cognitive complaints, performance on a cognitive flexibility test, and symptoms of anxiety, depression, post-traumatic stress, and fatigue significantly correlated with participation. Subjective cognitive functioning was the most significantly associated factor with participation according to regression analyses.Conclusion: These results raise the importance of implementing rehabilitation services that target cognitive complaints to promote better participation in this population.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Caregiving preparedness and depression as key predictors of quality of life in primary stroke caregivers: a cross-sectional study in Taiwan. 照护准备与抑郁是主要脑卒中照护者生活品质的预测因子：台湾的横断面研究。

IF 1.5 4区医学

Brain injury Pub Date : 2025-05-31 DOI: 10.1080/02699052.2025.2513613

Yi-Hsuan Lin, Hsiao-Mei Chen, Bei-Yi Su

{"title":"Caregiving preparedness and depression as key predictors of quality of life in primary stroke caregivers: a cross-sectional study in Taiwan.","authors":"Yi-Hsuan Lin, Hsiao-Mei Chen, Bei-Yi Su","doi":"10.1080/02699052.2025.2513613","DOIUrl":"https://doi.org/10.1080/02699052.2025.2513613","url":null,"abstract":"Purpose: This study examined how demographic factors, health status, and caregiving preparedness influence the quality of life (QoL) of primary caregivers of stroke patients in Taiwan.Methods: A cross-sectional survey was conducted with 145 caregivers at a central Taiwan hospital. Data were collected using the Caregiving Preparedness Scale (PCS), an 8-item tool assessing readiness in general care, emergency management, and resource access (5-point Likert scale), and the WHOQOL-BREF Taiwan version, a 28-item measure of physical, psychological, social, and environmental QoL.Results: The average QoL score was 56.5 out of 80, assessed using WHOQOL-BREF. Stepwise regression analysis identified key predictors of QoL, with variance explained by CESD scores (34.9%), caregiving preparedness (19.3%), caregiver age (8.3%), marital status (0.9%), caregiving time (0.8%), employment status (0.7%), patient age (1.2%), and IADL score (2.6%). The reported percentages reflect each factor's contribution to QoL variance.Conclusions: Support should be prioritized for caregivers with high depression scores, low caregiving preparedness, and socioeconomic vulnerabilities such as unemployment or low household income, to enhance their quality of life. The reported percentages reflect the variance in QoL explained by each predictor in the regression analysis.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling key determinants of cranial decompression in isolated severe traumatic brain injury: insights from a national trauma database. 揭示孤立的严重创伤性脑损伤颅骨减压的关键决定因素：来自国家创伤数据库的见解。

IF 1.5 4区医学

Brain injury Pub Date : 2025-05-31 DOI: 10.1080/02699052.2025.2513615

Stavros Matsoukas, Sean Inzerillo, Raymond V Wedderburn, Eric L Legome, Konstantinos Margetis, Divaldo Camara

{"title":"Unraveling key determinants of cranial decompression in isolated severe traumatic brain injury: insights from a national trauma database.","authors":"Stavros Matsoukas, Sean Inzerillo, Raymond V Wedderburn, Eric L Legome, Konstantinos Margetis, Divaldo Camara","doi":"10.1080/02699052.2025.2513615","DOIUrl":"https://doi.org/10.1080/02699052.2025.2513615","url":null,"abstract":"Background: Severe isolated traumatic brain injury (TBI) represents a complex and understudied population. Limited evidence exists on predictors of cranial decompression. This study aims to quantify the rate and identify factors associated with cranial decompression in severe isolated TBI using a large national database.Methods: Data from the 2019-2021 American College of Surgeons Trauma Quality Program was analyzed. Severe TBI was defined as a head Abbreviated Injury Scale (AIS) score ≥ 3. Demographics, vitals, comorbidities, and in-hospital complications were assessed using multivariable models to identify predictors of cranial decompression.Results: A total of 303,766 adults with severe isolated TBI were included (mean age 59.8; 64.2% male; 75.0% white). Cranial decompression was performed in 13.5% (n = 41,045). Univariate analysis showed significant differences in demographics, mechanism of injury, ICU admission, CT findings, midline shift, cerebral monitoring, blood product use, and complications. Multivariable analysis revealed that males, younger age, falls as the mechanism of injury, higher GCS, ICU admission, CT findings, need for cerebral monitoring, presence of midline shift, thromboembolism prophylaxis, and requirement for blood product transfusions, were strong predictors of cranial decompression.Conclusion: This study provides valuable insights into the independent predictors for the need of cranial decompression in severe isolated TBI patients.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-8"},"PeriodicalIF":1.5,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurophysiological and visual effects of cannabis, nicotine, and e-cigarettes on patients with TBI: a literature review. 大麻、尼古丁和电子烟对脑外伤患者的神经生理和视觉影响：文献综述。

IF 1.5 4区医学

Brain injury Pub Date : 2025-05-30 DOI: 10.1080/02699052.2025.2509162

Mohini Vadalia, Naveen K Yadav

{"title":"Neurophysiological and visual effects of cannabis, nicotine, and e-cigarettes on patients with TBI: a literature review.","authors":"Mohini Vadalia, Naveen K Yadav","doi":"10.1080/02699052.2025.2509162","DOIUrl":"https://doi.org/10.1080/02699052.2025.2509162","url":null,"abstract":"Purpose: The purpose of this literature review was to assess and evaluate the neurophysiological and visual effects of cannabis, nicotine, and e-cigarettes on patients with traumatic brain injury (TBI).Methods: In this review, a literature search was performed using PubMed and Google Scholar resources. In addition, a literature search within cited references was also performed for this review. A total of seventy-two(72) publications as referenced were used for this review.Discussion: This literature review is intended to address the neurophysiological and visual impairments of patients with TBI through a systematic review to identify the side effects of substance abuse disorders (SUDs) and specifically describe the impacts of cannabis, nicotine, and e-cigarettes on TBI patients, and conclude the current findings.Conclusion: This systematic evaluation is beneficial for the healthcare community and provides the potential to better assess the effects of these different harmful substances on patients who have suffered trauma to their brains.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-11"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between serum magnesium level and long-term prognosis of traumatic brain injury. 创伤性脑损伤患者血清镁水平与远期预后的关系。

IF 1.5 4区医学

Brain injury Pub Date : 2025-05-29 DOI: 10.1080/02699052.2025.2512785

Eujene Jung, Jung-Ho Lee, Hyeng-Kyu Park

{"title":"Association between serum magnesium level and long-term prognosis of traumatic brain injury.","authors":"Eujene Jung, Jung-Ho Lee, Hyeng-Kyu Park","doi":"10.1080/02699052.2025.2512785","DOIUrl":"10.1080/02699052.2025.2512785","url":null,"abstract":"Purpose: Our study aimed to investigate the association between initial serum magnesium levels and long-term functional outcomes in patients with TBI, accounting for variations across different age groups.Methods: This retrospective study included adult patients with TBI and intracranial injury treated at a level-1 trauma hospital. The primary exposure was on serum magnesium levels within 6 hour of emergency department admission. Study outcomes included 6-month mortality and disability, assessed using the Glasgow Outcome Scale (scores 1-3). Multilevel multivariable logistic regression analysis was conducted to determine the relationship between serum magnesium levels and study outcomes, with stratified analysis employed to investigate potential variations based on age groups.Results: Low magnesium levels were significantly associated with an increased risk of 6-month disability (Odds ratio (OR) 1.80, 95% confidence interval (CI): 1.14-2.68) and 6-month mortality (OR: 1.82, 95% CI: 1.03-2.99). This association remained significant exclusively among younger patients, with ORs of 2.70 (95% CI: 1.21-5.14) for 6-month disability and 2.33 (95%, CI: 1.11-4.49) for 6-month mortality when stratified by age.Conclusion: Low serum magnesium levels are associated with poorer long-term outcomes in patients with TBI, and this effect is especially pronounced in younger adults (18-64 years). Specifically, younger patients exhibiting hypomagnesemia demonstrated a higher incidence of 6-month disability and mortality. These findings suggest a need to identify the causative links and explore whether correcting serum magnesium levels will improve TBI prognosis across different age groups.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-8"},"PeriodicalIF":1.5,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge, familiarity and discrimination toward acquired brain injury in Chile: findings from the public, general practitioners and neurorehabilitation professionals. 智利对获得性脑损伤的认识、熟悉和歧视：来自公众、全科医生和神经康复专业人员的调查结果

IF 1.5 4区医学

Brain injury Pub Date : 2025-05-29 DOI: 10.1080/02699052.2025.2512782

María-José Bracho, Darinka Radovic, Héctor Ureta, Christian Salas

{"title":"Knowledge, familiarity and discrimination toward acquired brain injury in Chile: findings from the public, general practitioners and neurorehabilitation professionals.","authors":"María-José Bracho, Darinka Radovic, Héctor Ureta, Christian Salas","doi":"10.1080/02699052.2025.2512782","DOIUrl":"https://doi.org/10.1080/02699052.2025.2512782","url":null,"abstract":"Background: Stigma toward acquired brain injury (ABI) is often driven by a lack of knowledge and familiarity, which may reduce willingness to interact with survivors, affecting their well-being and recovery.Methods: This study explored the relationship between ABI knowledge, familiarity, and willingness to interact among the general public (n = 308), general practitioners (n = 105), and neurorehabilitation professionals (n = 123). A cross-sectional survey of 536 participants assessed knowledge (Common Misconceptions About Traumatic Brain Injury Questionnaire), familiarity (Familiarity Scale), and willingness to interact (Social Interaction Scale). Data were analyzed using Rasch modeling, principal component analysis, non-parametric tests, and a multivariate linear model.Results: Knowledge and familiarity explained a small yet significant portion of the variance in willingness to interact. Misconceptions were most common in the general public, yet general practitioners and rehabilitation professionals also showed gaps in understanding invisible impairments, and recovery. Rehabilitation professionals had the highest work-related familiarity, while general practitioners showed the highest willingness to interact.Discussion: Findings highlight the need for psychoeducation and contact-based interventions to reduce misconceptions and improve attitudes toward ABI survivors. Enhancing knowledge and familiarity may help reduce stigma, emphasizing the importance of further research and targeted interventions.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-16"},"PeriodicalIF":1.5,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modafinil/armodafinil for excessive daytime sleepiness after traumatic brain injury: a systematic review and meta-analysis. 莫达非尼/阿莫达非尼治疗创伤性脑损伤后白天嗜睡：系统回顾和荟萃分析。

IF 1.5 4区医学

Brain injury Pub Date : 2025-05-19 DOI: 10.1080/02699052.2025.2502424

Rafael Batista João, Niels Pacheco-Barrios, Marianna Leite, Ygor Roberto Ramos Gonçalves Soares, Zeynep Eylül Bakir, Maria Eduarda Veiga, Julyana Medeiros Dantas

{"title":"Modafinil/armodafinil for excessive daytime sleepiness after traumatic brain injury: a systematic review and meta-analysis.","authors":"Rafael Batista João, Niels Pacheco-Barrios, Marianna Leite, Ygor Roberto Ramos Gonçalves Soares, Zeynep Eylül Bakir, Maria Eduarda Veiga, Julyana Medeiros Dantas","doi":"10.1080/02699052.2025.2502424","DOIUrl":"https://doi.org/10.1080/02699052.2025.2502424","url":null,"abstract":"Objectives: Previous studies investigated pharmacological options for reducing excessive daytime sleepiness (EDS) after traumatic brain injury (TBI), with mixed results. This meta-analysis aimed to assess the efficacy and safety of modafinil or armodafinil in post-TBI persons experiencing EDS.Methods: We systematically searched PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov and identified studies comparing modafinil/armodafinil versus placebo for treating EDS after TBI. We computed pooled risk ratios (RR) or mean differences (MD) for binary and continuous outcomes, respectively. EDS was assessed using the Epworth Sleepiness Scale (ESS).Results: We included data from 158 individuals (mean age 34.28 years; 62.64% male) from three randomized controlled trials. In those treated with modafinil (dose range: 100-400 mg) or armodafinil (dose range: 150-250 mg), the mean ESS score was decreased in comparison with placebo (MD -1.65; 95% CI -3.26 to -0.04; p = 0.04). The risk of insomnia was higher in the modafinil/armodafinil group compared with the placebo group (RR 3.73; 95% CI 1.11 to 12.54; p = 0.03). There was no significant difference between groups in the risk of other adverse events (e.g., nausea, headache, dizziness, and nasopharyngitis).Conclusion: Modafinil/armodafinil effectively improved EDS after TBI, as compared with placebo, albeit with an increased risk of insomnia.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-9"},"PeriodicalIF":1.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0