Brain injury最新文献

Intranasal administration of enalapril confers acute neuroprotection by mitigating mitochondrial dysfunction and apoptosis in a rat model of ischemic stroke. 在缺血性脑卒中大鼠模型中，鼻内给药依那普利可通过减轻线粒体功能障碍和细胞凋亡提供急性神经保护。

IF 1.5 4区医学

Brain injury Pub Date : 2026-10-20 DOI: 10.1080/02699052.2026.2750459

Nooshin Sadeghian, Saied Salimpour Azar, Javad Shadman, Ali Abedi, Ahmad Salimi, Mohammad Reza Alipour, Hamdollah Panahpour

{"title":"Intranasal administration of enalapril confers acute neuroprotection by mitigating mitochondrial dysfunction and apoptosis in a rat model of ischemic stroke.","authors":"Nooshin Sadeghian, Saied Salimpour Azar, Javad Shadman, Ali Abedi, Ahmad Salimi, Mohammad Reza Alipour, Hamdollah Panahpour","doi":"10.1080/02699052.2026.2750459","DOIUrl":"https://doi.org/10.1080/02699052.2026.2750459","url":null,"abstract":"Background: Stroke remains a leading cause of mortality and long-term disability worldwide, with effective treatments hindered by its complex pathophysiology. This study is the first to explore the neuroprotective potential of intranasal enalapril, in mitigating ischemic stroke outcomes through its influence on mitochondrial function.Methods: Male Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO), followed by the intranasal administration of enalapril (0.03 mg/kg) post-ischemia. Neurological function was evaluated after 24 hours of reperfusion through the modified neurological severity score (mNSS), grip strength, and hot plate tests. Brain infarct volume was quantified via Triphenyltetrazolium chloride staining. Blood- brain barrier (BBB) integrity was evaluated via the Evans Blue extravasation assay. Additionally, we employed immunofluorescence techniques to assess apoptosis through TUNEL staining and evaluated mitochondrial function by examining mitochondrial swelling, succinate dehydrogenase activity, mitochondrial membrane potential and reactive oxygen species production.Results: Intranasal administration of enalapril significantly reduced the infarct volume, preserved BBB integrity, and attenuated sensorimotor deficits in MCAO rats. These protective effects were closely associated with enhanced regional cerebral blood flow, a significant reduction in neuronal apoptosis, and improved mitochondrial function.Conclusion: Intranasal enalapril may provide a novel approach to neuroprotection in ischemic stroke, potentially through mechanisms that enhance mitochondrial function and reduce neuronal apoptosis.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-15"},"PeriodicalIF":1.5,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistent Choice reaction-time slowing in collegiate athletes with a history of concussion. 有脑震荡史的大学生运动员的持续性选择反应时间减慢。

IF 1.5 4区医学

Brain injury Pub Date : 2026-10-16 DOI: 10.1080/02699052.2026.2750466

Amin Mohammadi, Joshua T Lawton, Eric Schussler, Thomas R Campbell

{"title":"Persistent Choice reaction-time slowing in collegiate athletes with a history of concussion.","authors":"Amin Mohammadi, Joshua T Lawton, Eric Schussler, Thomas R Campbell","doi":"10.1080/02699052.2026.2750466","DOIUrl":"https://doi.org/10.1080/02699052.2026.2750466","url":null,"abstract":"Objective: To determine whether collegiate athletes with a history of concussion exhibit persistent reaction-time deficits after accounting for SCAT6-based memory/concentration measures and computerized neurocognitive domain scores.Methods: 547 NCAA Division I athletes completed computerized neurocognitive testing, SCAT6-based symptom and cognitive assessments, and balance evaluations. Propensity-score matching produced 138 athletes with concussion history matched to 138 controls. Four RT outcomes were analyzed: Choice RT, Simple RT, Stroop RT, and Shifting-Attention RT. Multivariate analyses of covariance (MANCOVA) examined group differences controlling for SCAT6-based memory and concentration measures and CNS Vital Signs cognitive domain scores.Results: Athletes with a prior concussion demonstrated significantly slower Choice RT both before adjustment (p = 0.019) and after controlling for all covariates (p = 0.006). No significant group differences emerged for Simple RT, Stroop RT, or Shifting-Attention RT (all p 0 > .53). Executive function, cognitive flexibility, and visual memory showed consistent associations with RT performance across outcomes.Conclusion: History of concussion is selectively associated with persistent slowing in Choice RT, independent of SCAT6-based memory and concentration measures and CNS Vital Signs cognitive domain scores. Choice RT may be a sensitive marker of subtle neurocognitive slowing and may help inform both post-concussion assessment and rehabilitation planning.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-8"},"PeriodicalIF":1.5,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Living status and multidomain clinical outcomes in adults following acute mild traumatic brain injury. 急性轻度创伤性脑损伤后成人的生活状态和多领域临床结果。

IF 1.5 4区医学

Brain injury Pub Date : 2026-10-13 DOI: 10.1080/02699052.2026.2748371

Aaron J Zynda, Anthony P Kontos, Ryan Marra, Natalee Gallo, Marisa Hirsh, Jessa Darwin, John Maczuzak, Maria Pacella-LaBarbara, David J Barton, Amy K Wagner

{"title":"Living status and multidomain clinical outcomes in adults following acute mild traumatic brain injury.","authors":"Aaron J Zynda, Anthony P Kontos, Ryan Marra, Natalee Gallo, Marisa Hirsh, Jessa Darwin, John Maczuzak, Maria Pacella-LaBarbara, David J Barton, Amy K Wagner","doi":"10.1080/02699052.2026.2748371","DOIUrl":"https://doi.org/10.1080/02699052.2026.2748371","url":null,"abstract":"Background: The objective of this study was to evaluate the role of living status in multidomain clinical outcomes in adults following acute mild traumatic brain injury (mTBI).Methods: Adults presenting to emergency departments or a specialty concussion clinic within < 72 hours (h) of mTBI were enrolled. Multidomain clinical measures (e.g. Concussion Clinical Profile Screen [CP Screen], Patient Health Questionnaire 9 [PHQ-9], Post-Traumatic Stress Disorder Checklist [PCL-5], Perceived Stress Scale [PSS]) were collected at <72 h and 10 days (d) post-injury. Participants were grouped by living status: alone (Alone), with a spouse/significant other/roommate (Cohabitant), or with a partner and children/extended family (Family). Two-way mixed-effects models evaluated the interaction of group and time on clinical outcomes.Results: One hundred fourteen participants (age = 33.2 ± 13.8 years; 63F) were enrolled: 27 (24%) in the Alone group, 41 (36%) Cohabitant, and 46 (40%) Family. A significant interaction was observed for the CP Screen Cognitive/Fatigue (F[2,51] = 5.5, p = 0.007), PHQ-9 (F[2,49] = 4.3, p = 0.020), PCL-5 (F[2,51] = 3.3, p = 0.044), and PSS (F[2,50] = 3.9 , p = 0.027). The Alone group exhibited significant increases in Cognitive/Fatigue problems (Δ3.1, p < 0.001), depression symptoms (Δ5.4, p < 0.001), and PTSD (Δ10.1, p = 0.006), but a significant decrease in perceived stress (Δ-4.5, p = 0.012) over time compared to the Cohabitant and Family groups (p > 0.05).Conclusions: Adults living alone demonstrated a significant increase in cognitive/fatigue, depression, and stress-related symptoms from <72 h to 10d post-mTBI compared to those living with a cohabitant/family.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Venlafaxine modulates white matter integrity in dorsal and ventral language pathways after subcortical stroke: a longitudinal TBSS study. 文拉法辛调节皮层下脑卒中后背侧和腹侧语言通路白质完整性：一项纵向TBSS研究。

IF 1.5 4区医学

Brain injury Pub Date : 2026-10-12 DOI: 10.1080/02699052.2026.2748375

Chunyong Li, Leiyuan Liu, Lingjie Wang, Wei Zhang, Liu Liu, Qi Xie, Yan Liu

{"title":"Venlafaxine modulates white matter integrity in dorsal and ventral language pathways after subcortical stroke: a longitudinal TBSS study.","authors":"Chunyong Li, Leiyuan Liu, Lingjie Wang, Wei Zhang, Liu Liu, Qi Xie, Yan Liu","doi":"10.1080/02699052.2026.2748375","DOIUrl":"https://doi.org/10.1080/02699052.2026.2748375","url":null,"abstract":"Background: Subcortical aphasia results from disrupted cortico-subcortical language networks after left-hemispheric infarction. Venlafaxine, an SNRI, may accelerate language recovery, but its effects on white matter plasticity remain unclear. We used diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS) to assess early venlafaxine effects on dorsal and ventral language pathways in subacute stroke.Methods: Thirty-two patients with first-ever left subcortical infarction and mild-to-moderate aphasia were randomized to venlafaxine (n=16; 75 mg/day, day 7-week 4) or control (n=16). DTI was acquired at 30±7 and 90±7 days post-stroke. TBSS compared fractional anisotropy (FA) in language-related tracts using permutation testing with TFCE (corrected p<0.05). .Results: At Visit 2, venlafaxine recipients had higher FA in right superior longitudinal fasciculus/arcuate fasciculus (SLF/AF), bilateral inferior fronto-occipital fasciculi (IFOF), and left inferior longitudinal fasciculus (ILF), but lower FA in left SLF and uncinate fasciculus (UF). At Visit 3, FA increases extended to SLF/AF and UF, yielding bilateral dorsal and ventral enhancement; only right ILF FA decreased. FA changes positively correlated with aphasia quotient, spontaneous language fluency, and picture-naming improvements. .Conclusion: Early venlafaxine induces biphasic white matter remodeling: initial contralesional and bilateral ventral enhancement, followed by bilateral integration, suggesting optimized language network reorganization.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-9"},"PeriodicalIF":1.5,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149163608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virtual reality and VR-like technologies for the assessment and rehabilitation of concussion-related vestibular and oculomotor dysfunction: a systematic review. 虚拟现实和vr技术用于脑震荡相关前庭和动眼肌功能障碍的评估和康复：系统综述。

IF 1.5 4区医学

Brain injury Pub Date : 2026-10-11 DOI: 10.1080/02699052.2026.2744773

Dhirenbhai Kalal, Syeda Maryam Hassny

{"title":"Virtual reality and VR-like technologies for the assessment and rehabilitation of concussion-related vestibular and oculomotor dysfunction: a systematic review.","authors":"Dhirenbhai Kalal, Syeda Maryam Hassny","doi":"10.1080/02699052.2026.2744773","DOIUrl":"https://doi.org/10.1080/02699052.2026.2744773","url":null,"abstract":"Background: Vestibular and oculomotor dysfunction after concussion may cause persistent dizziness, imbalance, visual motion sensitivity, and functional limitation. Virtual reality (VR) and technologies are used for assessment and rehabilitation, but applications, devices, and outcomes remain heterogeneous. This review evaluated VR and VR-like technologies for concussion-related vestibular and oculomotor dysfunction.Methods: Following PRISMA 2020 and PROSPERO registration, CENTRAL, MEDLINE, PsycINFO, PubMed, and Scopus were searched from inception to 21 March 2026. Of 1,197 records, 997 remained after deduplication; 55 full texts were assessed and 10 studies included. Two reviewers independently screened studies and extracted data. Owing to heterogeneity, findings were synthesized narratively.Results: One study evaluated VR-based rehabilitation and nine examined assessment, validation, or symptom provocation. Rehabilitation outcomes improved across conventional, VR-based, and hybrid therapy groups, without consistent superiority of VR. Assessment studies suggested that standardized visual-motion environments may reveal postural, sensory-integration, or symptom-provocation responses not evident during static testing. However, findings varied by technology, recovery stage, task, and outcome. Eye-tracking showed poor diagnostic discrimination, and visual perturbation did not consistently demonstrate concussion-related impairment.Conclusion: VR may be a useful adjunct for standardized, repeatable, ecologically relevant assessment and rehabilitation, but evidence does not support stand-alone use or superiority over conventional therapy.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-16"},"PeriodicalIF":1.5,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of dexmedetomidine use with stroke-heart syndrome in critically ill patients with ischemic stroke: a MIMIC-IV study. 缺血性卒中危重患者右美托咪定与卒中-心脏综合征的相关性：一项MIMIC-IV研究

IF 1.5 4区医学

Brain injury Pub Date : 2026-10-10 DOI: 10.1080/02699052.2026.2739953

Chen Liu, Wei Wu, Xi Chen, Yanzhen Wang

{"title":"Association of dexmedetomidine use with stroke-heart syndrome in critically ill patients with ischemic stroke: a MIMIC-IV study.","authors":"Chen Liu, Wei Wu, Xi Chen, Yanzhen Wang","doi":"10.1080/02699052.2026.2739953","DOIUrl":"https://doi.org/10.1080/02699052.2026.2739953","url":null,"abstract":"Background: Stroke-heart syndrome (SHS) is associated with poor outcomes after ischemic stroke (IS), but the relationship between dexmedetomidine (DEX) use and SHS remains unclear.Objective: To evaluate the association between DEX use and SHS in critically ill patients with IS.Methods: This retrospective cohort study used MIMIC-IV v2.2. Patients with IS receiving mechanical ventilation were included. DEX exposure was defined as use within 72 hours after ICU admission. Multivariate logistic regression, inverse probability of treatment weighting (IPTW), restricted cubic splines, and subgroup analyses were performed.Results: Among 953 patients, 146 (15.3%) received DEX. In the fully adjusted model, DEX use was associated with lower odds of SHS (OR = 0.611, 95% CI: 0.398-0.929, p = 0.023). The associations of cumulative DEX dose (p-nonlinearity = 0.018) and treatment duration (p-anonlinearity = 0.011) with SHS were nonlinear. Antiplatelet therapy significantly modified the DEX-SHS association (p-interaction = 0.042).Conclusion: DEX use was associated with lower odds of SHS in critically ill patients with IS. Antiplatelet therapy may modify this association. Prospective studies are needed to confirm these findings.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-9"},"PeriodicalIF":1.5,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traumatic brain injury mechanism of injury in adults: analysis by injury severity and sex in the National Trauma Databank. 成人创伤性脑损伤机制：国家创伤数据库损伤严重程度和性别分析。

IF 1.5 4区医学

Brain injury Pub Date : 2026-10-09 DOI: 10.1080/02699052.2026.2736703

Nicole Hiebert, Janice Bell, Stephen Cavanagh, Christina Drake

{"title":"Traumatic brain injury mechanism of injury in adults: analysis by injury severity and sex in the National Trauma Databank.","authors":"Nicole Hiebert, Janice Bell, Stephen Cavanagh, Christina Drake","doi":"10.1080/02699052.2026.2736703","DOIUrl":"https://doi.org/10.1080/02699052.2026.2736703","url":null,"abstract":"Background: Traumatic brain injuries (TBIs) are a global health issue, causing significant morbidity, mortality, and healthcare costs. Despite their prevalence, research gaps remain, particularly regarding adults aged 18-64, sex disparities, mechanisms of injury (MOI), and moderate TBI severity.Methods: This cross-sectional study analyzed data from the National Trauma Data Bank (NTDB), comprising 747 trauma-designated hospitals (N = 299,856). The study examined sociodemographic characteristics associated with TBI severity overall and by sex, and tested for effect modification between TBI severity and MOI by sex. Multinomial logistic regression was used to assess associations between MOI and TBI severity, adjusting for covariates.Results: Significant effect modification was found between TBI severity and MOI by sex. Transportation-related TBIs were the most common MOI across all severities and sexes, emphasizing the need for targeted prevention strategies. Disparities were identified, with fewer severe TBI cases treated at level I trauma centers and larger hospitals, indicating barriers to optimal care. Females exhibited higher TBI severity compared to males.Conclusion: The study highlights the significant burden of transportation-related TBIs and sex disparities in injury outcomes, particularly the higher severity among females. These findings call for sex-specific prevention strategies and further research into post-injury outcomes and healthcare access for severe TBI cases.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-11"},"PeriodicalIF":1.5,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reconnecting the disconnected forebrain: multimodal resting-state bold dynamics underlying zolpidem-induced arousal in incomplete Locked-in syndrome. 重新连接断开的前脑：不完全闭锁综合征中唑吡坦诱导觉醒的多模态静息态大胆动力学。

IF 1.5 4区医学

Brain injury Pub Date : 2026-10-06 DOI: 10.1080/02699052.2026.2743021

Calixto Machado, Rafael Rodriguez-Rojas, Jose Jesus Sanchez, Raed Mualem

{"title":"Reconnecting the disconnected forebrain: multimodal resting-state bold dynamics underlying zolpidem-induced arousal in incomplete Locked-in syndrome.","authors":"Calixto Machado, Rafael Rodriguez-Rojas, Jose Jesus Sanchez, Raed Mualem","doi":"10.1080/02699052.2026.2743021","DOIUrl":"https://doi.org/10.1080/02699052.2026.2743021","url":null,"abstract":"Primary objective: Zolpidem paradoxically restores behavioral responsiveness and communication in select patients with severe disorders of consciousness and profound motor deafferentation. While the anterior forebrain mesocircuit hypothesis attributes this awakening to central thalamic disinhibition, macroscopic network dynamics and lower brainstem gating remain under-characterized in locked-in syndrome (LIS).Methods and procedures: A 45-year-old male with ventral pontine necrosis initially misdiagnosed as vegetative state/unresponsive wakefulness syndrome (VS/UWS) was formally identified with incomplete LIS through systematic ocular testing. Multimodal high-resolution MRI, deterministic diffusion tensor imaging (DTI) tractography, resting-state fMRI (before vs. after 10 mg oral zolpidem), dynamic sliding-window graph theory (45 s), infraslow BOLD spectral analysis (Slow-5: 0.010-0.027 Hz; Slow-4: 0.027-0.073 Hz), and seed-based thalamocortical coupling were acquired.Main outcomes and results: DTI confirmed focal basis pontis transection with extensive preservation of supratentorial projection architecture. Baseline fMRI exhibited aberrant, unsegregated cross-network hyperconnectivity. Zolpidem restored canonical modular boundaries, pruned noisy long-range edges, induced focal BOLD reactivation in primary motor (M1) and precuneal cores, shifted power into the infraslow Slow-5 domain, and markedly augmented thalamocortical coupling (thalamo-precuneus: r = 0.18 to 0.61; striato-thalamus: r = 0.33 to 0.75).Conclusions: Paradoxical awakening in incomplete LIS is underpinned by structural preservation of the supratentorial mantle. Beyond classical mesocircuit release, zolpidem engages brainstem gating structures, restoring modular segregation, infraslow frequency tuning, and cognitive-motor coupling.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-11"},"PeriodicalIF":1.5,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of recommendations for initial adult traumatic brain injury management across clinical practice guidelines and consensus statements: a scoping review. 初步成人创伤性脑损伤管理的临床实践指南和共识声明的建议比较：范围审查。

IF 1.5 4区医学

Brain injury Pub Date : 2026-10-01 DOI: 10.1080/02699052.2026.2733594

Ashly Arias-Obando, Saray Casanova-Cadavid, Santiago Cardona-Collazos, Mónica Gabriela Delgado-Caicedo, Lina Gabriela Piragauta-Barrera, Julian Santaella-Tenorio, Andrés Villarreal-Mondragón, Andres Mariano Rubiano-Escobar

{"title":"Comparison of recommendations for initial adult traumatic brain injury management across clinical practice guidelines and consensus statements: a scoping review.","authors":"Ashly Arias-Obando, Saray Casanova-Cadavid, Santiago Cardona-Collazos, Mónica Gabriela Delgado-Caicedo, Lina Gabriela Piragauta-Barrera, Julian Santaella-Tenorio, Andrés Villarreal-Mondragón, Andres Mariano Rubiano-Escobar","doi":"10.1080/02699052.2026.2733594","DOIUrl":"https://doi.org/10.1080/02699052.2026.2733594","url":null,"abstract":"Objective: Traumatic brain injury (TBI) is a leading cause of mortality and disability worldwide. We conducted a scoping review to identify, map, and compare recommendations for the initial medical management of adult TBI.Methods: Following Joanna Briggs Institute methodology and PRISMA-ScR, we searched PubMed/MEDLINE, Embase, Scopus, guideline repositories, and gray literature for English or Spanish language documents published from 2010 to 2026. Two reviewers independently screened records, charted recommendations across domains, and rated agreement using a priori categories; discrepancies were resolved by consensus or third reviewer.Results: Sixteen documents met inclusion criteria, including guidelines, consensus statements, and best-practice recommendations. Broad agreement existed for early neurological assessment, airway protection, avoidance of hypotension and hypoxemia, and timely neuroimaging. Heterogeneity remained in blood pressure and cerebral perfusion pressure targets, repeat imaging, definitions of neurological deterioration, escalation criteria, observation protocols, and discharge processes. Anticonvulsant prophylaxis and venous thromboembolism prevention were inconsistently addressed. Blood-based biomarkers appeared in only three documents and were limited to computed tomography decision-making.Conclusions: Although the fundamental principles of care were largely consistent, important differences remain in their operational implementation. Greater harmonization of clinical definitions and management pathways may facilitate more consistent application of evidence-based recommendations across healthcare settings.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-12"},"PeriodicalIF":1.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequency and diagnostic yield of CRPS-I in TBI: a 12-year retrospective cohort study at a Level I trauma center. TBI中CRPS-I的频率和诊断率：一项在一级创伤中心进行的12年回顾性队列研究。

IF 1.5 4区医学

Brain injury Pub Date : 2026-10-01 DOI: 10.1080/02699052.2026.2739948

Seon Jun Yoon, Jun Won Lee, Da Been Yun, Tae Sung Park, Jae Hyun Lee, Sang Hun Kim, Byeong-Ju Lee, Jin A Yoon, Yong Beom Shin, Myung-Jun Shin, Myung Hun Jang

{"title":"Frequency and diagnostic yield of CRPS-I in TBI: a 12-year retrospective cohort study at a Level I trauma center.","authors":"Seon Jun Yoon, Jun Won Lee, Da Been Yun, Tae Sung Park, Jae Hyun Lee, Sang Hun Kim, Byeong-Ju Lee, Jin A Yoon, Yong Beom Shin, Myung-Jun Shin, Myung Hun Jang","doi":"10.1080/02699052.2026.2739948","DOIUrl":"https://doi.org/10.1080/02699052.2026.2739948","url":null,"abstract":"Objective: To investigate the frequency and diagnostic yield of Complex Regional Pain Syndrome Type I (CRPS-I) among traumatic brain injury (TBI) patients and to identify objective clinical triggers and associated factors.Design: A 12-year retrospective cohort study.Setting: A Level I trauma center in South Korea.Participants: 5,773 TBI patients admitted between January 2011 and December 2022.Main outcome measures: CRPS-I was diagnosed using Budapest research criteria supported by three-phase bone scintigraphy (TPBS) in clinically suspected patients. We evaluated CRPS-I frequency, diagnostic yield, and associated factors via univariate analysis.Results: Of 5,773 patients, 123 underwent TPBS for clinical suspicion, confirming 24 CRPS-I cases. The observed frequency was 0.42%, with a 19.5% (24/123) diagnostic yield among suspected patients. Edema and motor limitation were present in confirmed cases. Among clinically suspected patients, those with confirmed CRPS-I were older than those without confirmed CRPS-I (63.3 vs. 53.9 years, p = 0.028), whereas global injury severity (GCS, ISS) showed no association.Conclusions: The 0.42% frequency underestimates true CRPS-I prevalence due to selective testing. However, a 19.5% diagnostic yield reveals significant under-recognition in cognitively impaired patients when relying on symptom-based criteria. Edema and motor limitation may serve as practical triggers for adjunctive TPBS evaluation in non-communicative survivors.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-6"},"PeriodicalIF":1.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0