Can the neuroprotective effects of memantine prevent the complications of brain injuries? A systematic review of animal models.

IF 1.8 4区医学 Q4 NEUROSCIENCES

Brain injury Pub Date : 2025-09-30 DOI:10.1080/02699052.2025.2561785

Mojtaba Mojtahedzadeh, Rezvan Hassanpour, Omid Moradi Moghaddam, Reza Bahman, Ehsan Emami, Elham Pourheidar

{"title":"Can the neuroprotective effects of memantine prevent the complications of brain injuries? A systematic review of animal models.","authors":"Mojtaba Mojtahedzadeh, Rezvan Hassanpour, Omid Moradi Moghaddam, Reza Bahman, Ehsan Emami, Elham Pourheidar","doi":"10.1080/02699052.2025.2561785","DOIUrl":null,"url":null,"abstract":"Background: Memantine is thought to function as a neuroprotective agent because of its impact on the progression of various neurodegenerative diseases. This study examines memantine's neuroprotective effects in reducing complications resulting from brain injuries.Methods: The keywords were searched in the PubMed, Scopus, and Web of Science databases. Human studies were excluded. SYRCLE's RoB was utilized to assess the quality of the studies.Results: Of 1543 articles reviewed up to November 20, 2024, 51 met the established inclusion and exclusion criteria. The results indicated a strong association between memantine administration and: 1) decreased infarct size, reduced number of apoptotic cells, less brain edema, lower oxidative stress index, and diminished inflammatory responses, alongside improved neurobehavioral outcomes in ischemic stroke models; 2) less hematoma expansion, reduced brain edema and damage, decreased inflammation, and notable enhancement in neurobehavioral function and survival in hemorrhagic stroke models, coupled with the prevention of delayed cerebral vasospasm in subarachnoid hemorrhage cases; and 3) diminished brain injury, reduced infarct volume, less oxidative stress, and marked improvement in neurofunctional recovery in traumatic brain injury models.Conclusions: Memantine's potential neuroprotective properties could improve neurofunctional outcomes for patients with acute brain injuries.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-13"},"PeriodicalIF":1.8000,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain injury","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/02699052.2025.2561785","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Memantine is thought to function as a neuroprotective agent because of its impact on the progression of various neurodegenerative diseases. This study examines memantine's neuroprotective effects in reducing complications resulting from brain injuries.

Methods: The keywords were searched in the PubMed, Scopus, and Web of Science databases. Human studies were excluded. SYRCLE's RoB was utilized to assess the quality of the studies.

Results: Of 1543 articles reviewed up to November 20, 2024, 51 met the established inclusion and exclusion criteria. The results indicated a strong association between memantine administration and: 1) decreased infarct size, reduced number of apoptotic cells, less brain edema, lower oxidative stress index, and diminished inflammatory responses, alongside improved neurobehavioral outcomes in ischemic stroke models; 2) less hematoma expansion, reduced brain edema and damage, decreased inflammation, and notable enhancement in neurobehavioral function and survival in hemorrhagic stroke models, coupled with the prevention of delayed cerebral vasospasm in subarachnoid hemorrhage cases; and 3) diminished brain injury, reduced infarct volume, less oxidative stress, and marked improvement in neurofunctional recovery in traumatic brain injury models.

Conclusions: Memantine's potential neuroprotective properties could improve neurofunctional outcomes for patients with acute brain injuries.

查看原文本刊更多论文

美金刚的神经保护作用能否预防脑损伤并发症？动物模型的系统综述。

背景：美金刚被认为是一种神经保护剂，因为它对各种神经退行性疾病的进展有影响。本研究探讨美金刚在减少脑损伤并发症方面的神经保护作用。方法：检索PubMed、Scopus和Web of Science数据库中的关键词。排除了人体研究。使用sycle的RoB来评估研究的质量。结果：截至2024年11月20日，在1543篇文献中，51篇符合纳入和排除标准。结果表明，美金刚给药与：1)缺血性卒中模型中梗死面积减小、凋亡细胞数量减少、脑水肿减轻、氧化应激指数降低、炎症反应减轻以及神经行为预后改善之间存在密切关联；2)出血性脑卒中模型血肿扩张少，脑水肿和脑损伤减轻，炎症减轻，神经行为功能和生存率显著提高，蛛网膜下腔出血患者迟发性脑血管痉挛的预防作用显著；3)创伤性脑损伤模型脑损伤减轻，梗死体积减小，氧化应激减轻，神经功能恢复明显改善。结论：美金刚的潜在神经保护特性可以改善急性脑损伤患者的神经功能预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Brain injury 医学-康复医学

CiteScore

3.50

自引率

5.30%

发文量

148

审稿时长

12 months

期刊介绍： Brain Injury publishes critical information relating to research and clinical practice, adult and pediatric populations. The journal covers a full range of relevant topics relating to clinical, translational, and basic science research. Manuscripts address emergency and acute medical care, acute and post-acute rehabilitation, family and vocational issues, and long-term supports. Coverage includes assessment and interventions for functional, communication, neurological and psychological disorders.