Brain injury最新文献

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Understanding factors influencing exercise program adherence for youth with persistent post-concussive symptoms (PPCS). 了解影响有持续性脑震荡后症状(PPCS)的青少年坚持运动计划的因素。
IF 1.5 4区 医学
Brain injury Pub Date : 2025-03-21 Epub Date: 2024-11-19 DOI: 10.1080/02699052.2024.2428404
Beth J Bollinger, Sara Pd Chrisman, Jordan Sahlberg, Jason A Mendoza, Tonya M Palermo, Chuan Zhou, M Alison Brooks, Frederick P Rivara, Payton Pedersen, Emily Prentice, Colby Hansen
{"title":"Understanding factors influencing exercise program adherence for youth with persistent post-concussive symptoms (PPCS).","authors":"Beth J Bollinger, Sara Pd Chrisman, Jordan Sahlberg, Jason A Mendoza, Tonya M Palermo, Chuan Zhou, M Alison Brooks, Frederick P Rivara, Payton Pedersen, Emily Prentice, Colby Hansen","doi":"10.1080/02699052.2024.2428404","DOIUrl":"10.1080/02699052.2024.2428404","url":null,"abstract":"<p><strong>Background: </strong>A significant portion of youth sustain a concussion every year, with around 30% experiencing persistent post-concussion symptoms (PPCS). Research has shown exercising just below the exertion level that provokes symptoms can lead to more rapid recovery. However, youth often struggle to adhere to exercise recommendations following concussion.</p><p><strong>Methods: </strong>We conducted structured qualitative interviews (<i>n</i> = 32) with concussed youth and their parents to examine factors influencing motivation to engage in exercise post-concussion. Questions were framed through the lens of Self-Determination Theory (SDT) and Thematic Analysis was used to code and analyze transcripts.</p><p><strong>Results: </strong>Four primary factors appeared to motivate youth to exercise after receiving a concussion: 1) social support, 2) accountability, 3) goal setting, and 4) structure. Utilizing the lens of SDT, one could theorize that including social support and accountability helped fulfill the need of relatedness, setting goals helped fulfill the need of autonomy, and providing program structure helped fulfill the need for competence.</p><p><strong>Conclusions: </strong>Our results suggest that Self-Determination Theory may be a useful frame for examining exercise adherence post-concussion. Incorporating social support, accountability, goal setting and structure could increase the effectiveness of exercise prescription post-concussion and should be the focus of further study.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"286-299"},"PeriodicalIF":1.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case management for acquired brain injury: a systematic review of the evidence base. 后天性脑损伤的病例管理:证据基础的系统回顾。
IF 1.5 4区 医学
Brain injury Pub Date : 2025-03-01 Epub Date: 2024-12-10 DOI: 10.1080/02699052.2024.2438785
Rachel Leonard, Mark A Linden, Mark Holloway
{"title":"Case management for acquired brain injury: a systematic review of the evidence base.","authors":"Rachel Leonard, Mark A Linden, Mark Holloway","doi":"10.1080/02699052.2024.2438785","DOIUrl":"10.1080/02699052.2024.2438785","url":null,"abstract":"<p><strong>Background: </strong>Brain Injury Case management involves coordinating and organizing services and systems around people with acquired brain injuries' and their families. This review aimed to answer the question: What is the current available evidence for the use of case management in supporting survivors of ABI?</p><p><strong>Methods: </strong>Searches were conducted in seven databases (Medline (all), CINAHL, Embase, PsychInfo, Scopus, Web of Science, and PubMed), using a search strategy based on key terms: 'case management' and 'brain injury.' Quality of studies was assessed by the Mixed Methods Assessment Tool (MMAT), and the Joanna Briggs Institute (JBI) checklists. Findings were presented narratively.</p><p><strong>Results: </strong>A narrative synthesis of 35 included studies highlighted the challenges of measuring and evaluating the impact of case management for brain injury, vital aspects of case management, such as good communication and relationships, supporting the wider family, and case management across the continuum of care.</p><p><strong>Conclusions: </strong>Case managers play a pivotal role in the support and rehabilitation of people with ABI. The rapid evolution of case management has resulted in some challenges, such as lack of regulatory oversight and governance, and lack of standardization in treatment approaches. Future progression requires collaboration to produce better outcomes for clients and their families.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"337-358"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What are the views of those participating in a trial investigating acute post-traumatic benign paroxysmal positional vertigo? A qualitative study. 参与一项调查急性创伤后良性阵发性位置性眩晕的试验的人有什么看法?定性研究。
IF 1.5 4区 医学
Brain injury Pub Date : 2025-03-01 Epub Date: 2024-12-03 DOI: 10.1080/02699052.2024.2435952
Rebecca M Smith, Bithi Sahu, Caroline Burgess, Jenna Beattie, Abby Newdick, Vassilios Tahtis, Jonathan Marsden, Barry M Seemungal
{"title":"What are the views of those participating in a trial investigating acute post-traumatic benign paroxysmal positional vertigo? A qualitative study.","authors":"Rebecca M Smith, Bithi Sahu, Caroline Burgess, Jenna Beattie, Abby Newdick, Vassilios Tahtis, Jonathan Marsden, Barry M Seemungal","doi":"10.1080/02699052.2024.2435952","DOIUrl":"10.1080/02699052.2024.2435952","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to explore the experiences of patients and healthcare professionals participating in a randomized feasibility trial exploring the management of acute post-traumatic benign paroxysmal positional vertigo (BPPV), and to establish the acceptability and tolerability of BPPV assessment and treatment procedures.</p><p><strong>Methods: </strong>This was a multi-center qualitative study nested within a wider randomized feasibility trial. Purposive sampling was used to gather a cohort of healthcare professionals and patients from three major trauma centres in London, UK. Data were gathered using semi-structured interviews and were analyzed using Framework analysis.</p><p><strong>Results: </strong>Fifteen healthcare professionals and 26 patients participated. Patients and healthcare professionals reported acute BPPV diagnosis was acceptable and practicable. However, divergence was noted regarding views of randomization. Participants proposed several research delivery and protocol modifications for a future trial, including changes to study design and outcome measures.</p><p><strong>Conclusions: </strong>Healthcare professionals and patients participating in a multi-center qualitative study felt post-traumatic BPPV was feasible and acceptable to diagnose and treat acutely. Findings from this study will enhance the content and delivery of a future trial and may assist in influencing the development of clinical practice guidelines.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"400-409"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective effects of puerarin combined with bone marrow mesenchymal stem cells on nerve injury in rats with ischemic stroke. 葛根素联合骨髓间充质干细胞对缺血性脑卒中大鼠神经损伤的保护作用。
IF 1.5 4区 医学
Brain injury Pub Date : 2025-03-01 Epub Date: 2024-11-28 DOI: 10.1080/02699052.2024.2433667
Jiane Chen, Xiaoli Wu, Dongliang Nie, Zhimin Yu
{"title":"Protective effects of puerarin combined with bone marrow mesenchymal stem cells on nerve injury in rats with ischemic stroke.","authors":"Jiane Chen, Xiaoli Wu, Dongliang Nie, Zhimin Yu","doi":"10.1080/02699052.2024.2433667","DOIUrl":"10.1080/02699052.2024.2433667","url":null,"abstract":"<p><strong>Background: </strong>Bone marrow mesenchymal stem cells (BM-MSCs) transplantation shows promise for treating ischemic stroke, but the ischemic environment that follows cerebral infarction hinders the survival of transplanted cells. We aimed to study the effects of puerarin (Pue) in combination with BM-MSCs on cerebral ischemic injury.</p><p><strong>Methods: </strong>After middle cerebral artery occlusion (MCAO) models were prepared by suture-occluded method, rats were randomly allocated to the sham, MCAO, Pue (50 mg/kg), BM-MSCs (2×106), and BM-MSCs+Pue groups. The neurological function, infarct area, levels of inflammation-related factors, brain tissue damage, apoptosis, BrdU, Beclin1, and LC3 levels were then assessed.</p><p><strong>Results: </strong>Pue and BM-MSCs reduced the modified neurological severity score, cerebral infarction area, and serum inflammation-related factor levels for MCAO rats. Furthermore, Pue and BM-MSCs interventions ameliorated brain tissue damage, and repressed apoptosis of brain tissues in MCAO rats. Moreover, Pue or BM-MSCs enhanced BrdU expression, restrained LC3II/LC3I ratio and Beclin 1 expression in MCAO rats' brain tissues. Importantly, the combination of Pue and BM-MSCs exhibited more pronounced effects on aforementioned outcomes.</p><p><strong>Conclusion: </strong>The combination of Pue and BM-MSCs facilitated the recovery of neurological function in rats after cerebral ischemic damage, and the mechanisms may correlate with the repression of neuronal apoptosis, inflammation, and autophagy.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"370-380"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differing clinical characteristics among individuals with concussions sustained at work, in motor vehicle collisions, and sport. 工作、机动车碰撞和运动中持续脑震荡个体的不同临床特征。
IF 1.5 4区 医学
Brain injury Pub Date : 2025-03-01 Epub Date: 2024-12-17 DOI: 10.1080/02699052.2024.2441846
Jacob I McPherson, Andrew Nowak, Haley Chizuk, John J Leddy, Mohammad N Haider
{"title":"Differing clinical characteristics among individuals with concussions sustained at work, in motor vehicle collisions, and sport.","authors":"Jacob I McPherson, Andrew Nowak, Haley Chizuk, John J Leddy, Mohammad N Haider","doi":"10.1080/02699052.2024.2441846","DOIUrl":"10.1080/02699052.2024.2441846","url":null,"abstract":"<p><strong>Purpose: </strong>To compare clinical characteristics in patients with concussions sustained by prevalent, but understudied, mechanisms (work-related concussion [WRC] and motor vehicle collision [MVC]-related concussion) to sport-related concussion (SRC).</p><p><strong>Methods: </strong>Retrospective review of 281 electronic medical records from an outpatient concussion clinic. Time since injury (days), duration of care (days), amount of care (number of visits), and perceived health (Short-Form 12) were collected.</p><p><strong>Results: </strong>The time between injury and clinic presentation was significantly greater in WRC and MVC-related concussion compared to SRC. These groups were also older, had a longer duration of care, required more referrals for outside clinical services, and reported worse perceived mental and physical health versus SRC.</p><p><strong>Conclusion: </strong>These results suggest that clinical courses may be significantly different for individuals with SRC, WRC and MVC-related concussion, and that different management approaches and expectations may be necessary for these groups. Further research is indicated.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"420-426"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The neuroprotective potential of carbazole in traumatic brain injury. 咔唑对创伤性脑损伤的神经保护作用。
IF 1.5 4区 医学
Brain injury Pub Date : 2025-03-01 Epub Date: 2024-12-18 DOI: 10.1080/02699052.2024.2441843
Akashdeep Singh Pathania, Kavita Badhai, Nirmal Singh, Dimple Sethi Chopra, Dhandeep Singh
{"title":"The neuroprotective potential of carbazole in traumatic brain injury.","authors":"Akashdeep Singh Pathania, Kavita Badhai, Nirmal Singh, Dimple Sethi Chopra, Dhandeep Singh","doi":"10.1080/02699052.2024.2441843","DOIUrl":"10.1080/02699052.2024.2441843","url":null,"abstract":"<p><strong>Objective: </strong>To review the neuroprotective potential of carbazole and its derivatives in the management of traumatic brain injury (TBI), focusing on their mechanisms of action, preclinical findings, and potential clinical applications.</p><p><strong>Data sources: </strong>Relevant literature was identified through a comprehensive search of PubMed, Embase, Medline, Web of Science, and the Cochrane Library databases.</p><p><strong>Review methods: </strong>This review includes an analysis of studies investigating the neuroprotective properties of carbazole, emphasizing its anti-apoptotic, antioxidative, neurotrophic, and mitochondrial protective mechanisms. The scope of the review covers preclinical studies and explores future directions for clinical translation.</p><p><strong>Results: </strong>Carbazole compounds demonstrate significant neuroprotective effects by reducing oxidative stress, inhibiting apoptosis, and promoting neuroregeneration in preclinical models of TBI. These compounds also potentially preserve blood-brain barrier integrity and modulate inflammatory responses. However, clinical studies evaluating carbazole-based therapies in human subjects are limited, highlighting a critical gap in translational research.</p><p><strong>Conclusion: </strong>Carbazole and its derivatives are promising therapeutic agents for mitigating secondary damage and enhancing recovery in TBI. Further research is warranted to establish their efficacy and safety in clinical settings and to explore their potential as part of combination therapies for TBI management.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"359-369"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnetic resonance imaging in traumatic brain injury: a survey of clinical practitioners' experiences and views on current practice and obstacles. 外伤性脑损伤的磁共振成像:临床医生的经验和对当前实践和障碍的看法的调查。
IF 1.5 4区 医学
Brain injury Pub Date : 2025-03-01 Epub Date: 2025-01-29 DOI: 10.1080/02699052.2024.2443001
Karen Caeyenberghs, Mervyn Singh, Annalee L Cobden, Elizabeth G Ellis, Liam G Graeme, Priscilla Gates, Alex Burmester, Jade Guarnera, Jake Burnett, Evelyn M Deutscher, Lyndon Firman-Sadler, Bec Joyce, Jacqueline P Notarianni, Christian Pardo de Figueroa Flores, Juan F Domínguez D
{"title":"Magnetic resonance imaging in traumatic brain injury: a survey of clinical practitioners' experiences and views on current practice and obstacles.","authors":"Karen Caeyenberghs, Mervyn Singh, Annalee L Cobden, Elizabeth G Ellis, Liam G Graeme, Priscilla Gates, Alex Burmester, Jade Guarnera, Jake Burnett, Evelyn M Deutscher, Lyndon Firman-Sadler, Bec Joyce, Jacqueline P Notarianni, Christian Pardo de Figueroa Flores, Juan F Domínguez D","doi":"10.1080/02699052.2024.2443001","DOIUrl":"10.1080/02699052.2024.2443001","url":null,"abstract":"<p><strong>Introduction: </strong>Magnetic resonance imaging (MRI) has revolutionized our capacity to examine brain alterations in traumatic brain injury (TBI). However, little is known about the level of implementation of MRI techniques in clinical practice in TBI and associated obstacles.</p><p><strong>Methods: </strong>A diverse set of health professionals completed 19 multiple choice and free text survey questions.</p><p><strong>Results: </strong>Of the 81 respondents, 73.4% reported that they acquire/order MRI scans in TBI patients, and 66% indicated they would prefer MRI be more often used with this cohort. The greatest impediment for MRI usage was scanner availability (57.1%). Less than half of respondents (42.1%) indicated that they perform advanced MRI analysis. Factors such as dedicated experts within the team (44.4%) and user-friendly MRI analysis tools (40.7%), were listed as potentially helpful to implement advanced MRI analyses in clinical practice.</p><p><strong>Conclusion: </strong>Results suggest a wide variability in the purpose, timing, and composition of the scanning protocol of clinical MRI after TBI. Three recommendations are described to broaden implementation of MRI in clinical practice in TBI: 1) development of a standardized multimodal MRI protocol; 2) future directions for the use of advanced MRI analyses; 3) use of low-field MRI to overcome technical/practical issues with high-field MRI.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"427-443"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic significance of serum hsa_circ_0000745 and hsa_circ_0001459 in ischemic stroke and its role in the prognosis of interventional therapy. 缺血性脑卒中血清 hsa_circ_0000745 和 hsa_circ_0001459 的诊断意义及其在介入治疗预后中的作用。
IF 1.5 4区 医学
Brain injury Pub Date : 2025-03-01 Epub Date: 2024-11-27 DOI: 10.1080/02699052.2024.2433668
Gaoyi Li, Tao Peng, Jingquan Zhang
{"title":"Diagnostic significance of serum hsa_circ_0000745 and hsa_circ_0001459 in ischemic stroke and its role in the prognosis of interventional therapy.","authors":"Gaoyi Li, Tao Peng, Jingquan Zhang","doi":"10.1080/02699052.2024.2433668","DOIUrl":"10.1080/02699052.2024.2433668","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to identify hsa_circ_0000745 and hsa_circ_0001459 expression, value as biomarkers in ischemic stroke (IS), and functions in BV2 cells.</p><p><strong>Methods: </strong>RNA sequencing datasets in the GEO database were retrieved. The expression of circulating hsa_circ_0000745 and hsa_circ_0001459 was validated by RT-qPCR. The predictive values of hsa_circ_0000745 and hsa_circ_0001459 in the diagnosis and outcome of acute IS were evaluated using receiver operator characteristic curve analysis. BV2 cells were treated with lipopolysaccharide, followed by hsa_circ_0000745 or hsa_circ_0001459 downregulation and subsequent migration and apoptosis assay. The downstream miR-1287-5p was detected using the luciferase reporter gene assay.</p><p><strong>Results: </strong>Hsa_circ_0000745 or hsa_circ_0001459 were upregulated in acute IS. Hsa_circ_0000745 or/and hsa_circ_0001459 differentiated between healthy control subjects and patients with IS, resulting in areas under curve (AUC) of 0.85 and 0.83, respectively. Hsa_circ_0000745 or hsa_circ_0001459 was positively correlated with serum pro-inflammatory cytokines and the NIHSS (<i>P</i><0.001). Longitudinal and ROC analyses of hsa_circ_0001459 and hsa_circ_0000745 expression levels revealed the 90-day-outcome-predicting potential after stroke. Hsa_circ_0001459 and hsa_circ_0000745 promoted the apoptosis and inhibited the migration of LPS-induced BV2 cells. Hsa_circ_0001459 and hsa_circ_0000745 commonly sponged miR-1287-5p.</p><p><strong>Conclusions: </strong>Hsa_circ_0001459 and hsa_circ_0000745 showed upregulations in IS and might have clinical utility as a diagnostic and outcome-predicting marker.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"381-389"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-concussion changes in the N200 and P300 ERPs are associated with cognitive symptoms and performance. 脑震荡后N200和P300 erp的变化与认知症状和表现有关。
IF 1.5 4区 医学
Brain injury Pub Date : 2025-03-01 Epub Date: 2024-12-04 DOI: 10.1080/02699052.2024.2435947
Patrick S Ledwidge, Lindsey C Hartland, Chloe A Huston, Christa M Jones, Erin Neff, Elizabeth Castro, John P Abt
{"title":"Post-concussion changes in the N200 and P300 ERPs are associated with cognitive symptoms and performance.","authors":"Patrick S Ledwidge, Lindsey C Hartland, Chloe A Huston, Christa M Jones, Erin Neff, Elizabeth Castro, John P Abt","doi":"10.1080/02699052.2024.2435947","DOIUrl":"10.1080/02699052.2024.2435947","url":null,"abstract":"<p><strong>Purpose: </strong>To examine how post-concussion changes to the N200 and P300 event-related potentials (ERPs) are associated with cognitive symptoms and neurocognitive performance.</p><p><strong>Methods: </strong>High-density electroencephalography (EEG) was recorded during a Go/No-Go task from 16 young adults within one month after their concussion and 16 matched controls. Participants were also administered the Cognitive-Linguistic Quick Test (CLQT) and self-reported concussion-like symptoms. Mixed analysis of variance models compared the N200/P300 ERPs between concussion and control groups. Nested linear regressions examined associations between the N200/P300 ERPs and CLQT cognitive domains, cognitive symptom clusters, and total concussion symptoms, with particular interest in within-task changes in the N200/P300 ERPs (e.g. habituation).</p><p><strong>Results: </strong>N200 and P300 ERP amplitudes were associated with individual differences in cognitive outcomes after concussion. For concussion participants only, smaller P300 amplitudes were significantly associated with greater cognitive symptoms. When considering within-task changes in ERPs over repeated trial presentations, reduced habituation of N200 amplitudes was significantly associated with poorer attention and memory CLQT domain scores. Reduced habituation of P300 amplitudes was also associated with greater cognitive symptoms and total symptoms for concussion participants.</p><p><strong>Conclusion: </strong>Within-task changes in ERP dynamics supporting attention and executive control are associated with individual differences in cognitive outcomes after concussion.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"390-399"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterizing supplement use and dietary behaviors in adults with acquired brain injury. 成年后天性脑损伤患者的补品使用和饮食行为特征
IF 1.8 4区 医学
Brain injury Pub Date : 2025-03-01 Epub Date: 2024-12-08 DOI: 10.1080/02699052.2024.2436594
Melanie H Vergeer, Leah J Mercier, Samantha J McIntosh, Chloe Boucher, Robyn F Madden, Jane Shearer, Chantel T Debert
{"title":"Characterizing supplement use and dietary behaviors in adults with acquired brain injury.","authors":"Melanie H Vergeer, Leah J Mercier, Samantha J McIntosh, Chloe Boucher, Robyn F Madden, Jane Shearer, Chantel T Debert","doi":"10.1080/02699052.2024.2436594","DOIUrl":"10.1080/02699052.2024.2436594","url":null,"abstract":"<p><strong>Background: </strong>Acquired brain injury (ABI) can result in persistent symptoms and lasting disability. Supplements are becoming more popular in patients with chronic symptoms; however, little is known about supplementation and dietary behaviors after ABI.</p><p><strong>Methods: </strong>In this cross-sectional observational study, questionnaires were collected from 211 adults with ABI presenting to outpatient brain injury clinics. The temporality of 54 unique supplements and 15 dietary behaviors were surveyed. Sources of information, reasons for use, side effects, and perceived safety were obtained.</p><p><strong>Results: </strong>After ABI, 55% of the participants increased supplement utilization by ≥1 supplement, resulting in 74% consuming supplements (3.8<b>±</b>4.1 unique supplements daily); Vitamin D, multivitamins, magnesium, and omega 3- and/or -6 were most commonly consumed. Healthcare professionals were the main source of information, as reported by 69% of the respondents. The primary reason for supplementation was following a recommendation by a healthcare professional (63%). Supplementation was widely considered safe (83%), and most participants (76%) did not experience side effects. The majority of participants (70%) did not adhere to specific dietary behaviors.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"410-419"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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