Brain injury最新文献_第8页

Time-to-surgery for traumatic brain injury in the hyperacute period: a systemic review and meta-analysis. 超急性期脑外伤的手术时间：系统回顾和荟萃分析。

IF 1.5 4区医学

Brain injury Pub Date : 2025-02-23 Epub Date: 2024-11-08 DOI: 10.1080/02699052.2024.2425735

Lijian Zhang, Hongfang Zhao, Luxuan Wang, Yanfang Shi, Chunhui Li

{"title":"Time-to-surgery for traumatic brain injury in the hyperacute period: a systemic review and meta-analysis.","authors":"Lijian Zhang, Hongfang Zhao, Luxuan Wang, Yanfang Shi, Chunhui Li","doi":"10.1080/02699052.2024.2425735","DOIUrl":"10.1080/02699052.2024.2425735","url":null,"abstract":"Objective: To study the functional outcomes of traumatic brain injury (TBI) patients who have undergone surgical intervention in the hyperacute phase (<24 h).Data sources: Cochrane Library, PubMed, Embase, Medline and Web of Science databases.Review methods: A meta-analysis of 7 trials involving 237 patients was performed. Patients were categorized into two groups based on time to surgery: within 6 h and within 24 h. Patients were also categorized into developed and developing regions. Effect estimates were calculated using a fixed-effects model and heterogeneity was assessed with Cochrane I² statistic.Results: Our findings revealed that those who underwent neurosurgery in the hyperacute phase of TBI were at risk of adverse outcomes. The odds ratio (OR) was 1.50 (95% CI 1.03-2.19). Subgroup analysis demonstrated that TBI patients who underwent surgery within 6 h were at a greater risk of adverse effects (OR, 1.72; 95% CI, 1.08-2.74). Moreover, a greater risk was observed in developing regions (OR, 2.33; 95% CI, 0.97-5.58).Conclusion: Earlier neurosurgical intervention in the acute phase of TBI might result in higher incidence of adverse events. Surgery would be postponed for TBI patients whose initial GCS score is greater than 8 during the hyperacute period.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"179-186"},"PeriodicalIF":1.5,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of intractable paradoxical herniation by invasive mechanical ventilation with increased positive end-expiratory pressure: a case report. 通过增加呼气末正压的有创机械通气治疗顽固性矛盾性疝气：病例报告。

IF 1.5 4区医学

Brain injury Pub Date : 2025-02-23 Epub Date: 2024-11-01 DOI: 10.1080/02699052.2024.2419379

Shanwen Chen

{"title":"Treatment of intractable paradoxical herniation by invasive mechanical ventilation with increased positive end-expiratory pressure: a case report.","authors":"Shanwen Chen","doi":"10.1080/02699052.2024.2419379","DOIUrl":"10.1080/02699052.2024.2419379","url":null,"abstract":"Objective: Paradoxical herniation (PH) is a rare but potentially life-threatening complication after decompressive craniectomy. The core treatment strategy for PH focuses on increasing intracranial pressure. Here, we present the treatment course of intractable PH in a 59-year-old patient with a traumatic acute subdural hematoma.Methods: The patient underwent two operations to evacuate intracranial hematomas followed by decompressive craniectomy within 48 h. Intractable PH was induced by persistent cerebrospinal fluid leakage due to multiple lumbar punctures. The condition was managed with conventional interventions, such as a supine position, intravenous fluid infusion, and multiple intrathecal saline injections, which have been proven to be inefficient. Owing to his unconsciousness and concurrent severe pneumonia, the patient underwent invasive mechanical ventilation with increased positive end-expiratory pressure (PEEP) to optimize oxygen delivery. PEEP was set at 10 cmH2O with the intention of facilitating alveolar recruitment.Results: Increased PEEP unexpectedly played a role in elevating intracranial pressure and, as a result, led to the complete resolution of PH. The patient gradually recovered and resumed his daily activities.Conclusions: Applying invasive mechanical ventilation with increased PEEP for treating intractable PH can yield a favorable outcome. It represents a novel approach to dealing with such a rare complication.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"241-246"},"PeriodicalIF":1.5,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional network disruptions in youth with concussion using the Adolescent Brain Cognitive Development study. 利用青少年大脑认知发展研究发现脑震荡青少年的功能网络紊乱。

IF 1.5 4区医学

Brain injury Pub Date : 2025-02-23 Epub Date: 2024-10-16 DOI: 10.1080/02699052.2024.2416545

Elena Sheldrake, Eman Nishat, Anne L Wheeler, Benjamin I Goldstein, Nick Reed, Shannon E Scratch

{"title":"Functional network disruptions in youth with concussion using the Adolescent Brain Cognitive Development study.","authors":"Elena Sheldrake, Eman Nishat, Anne L Wheeler, Benjamin I Goldstein, Nick Reed, Shannon E Scratch","doi":"10.1080/02699052.2024.2416545","DOIUrl":"10.1080/02699052.2024.2416545","url":null,"abstract":"Objective: This study aimed to compare psychosocial outcomes and functional neuroimaging among youth with concussion, youth with anxiety, and age- and sex-matched controls.Methods: Using archival data from the Adolescent Brain Cognitive DevelopmentSM Study, we analyzed between-group differences in psychosocial outcomes measured by the Child Behavior Checklist's internalizing and externalizing problem scales, and assessed brain function using resting-state fMRI network-region connectivity (specifically frontoparietal network (FPN) and default mode network (DMN) connectivity with the amygdala).Results: Significant differences in psychosocial outcomes were found across all groups, with the anxiety group reporting the most internalizing problems, followed by the concussion group which significantly differed from controls. Additionally, FPN-amygdala connectivity was significantly reduced in the concussion group only; this reduced connectivity did not predict psychosocial outcomes across groups.Conclusion: This study provided preliminary findings that brain connectivity is reduced exclusively in individuals with concussion. Although disruptions were observed in the concussion group, further investigation is warranted to understand how disruptions may be associated with concussion symptoms. Studies that utilize well-defined control and study groups, and comprehensive cognitive and mental health measures will offer a deeper understanding of the relationship between brain function and psychosocial outcomes.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"199-210"},"PeriodicalIF":1.5,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LIMBIC military and tactical athlete research study: making lemonade 101. LIMBIC 军事和战术运动员研究：制作柠檬水 101。

IF 1.5 4区医学

Brain injury Pub Date : 2025-01-28 Epub Date: 2024-08-23 DOI: 10.1080/02699052.2024.2392251

Jacob E Resch, David X Cifu

{"title":"LIMBIC military and tactical athlete research study: making lemonade 101.","authors":"Jacob E Resch, David X Cifu","doi":"10.1080/02699052.2024.2392251","DOIUrl":"10.1080/02699052.2024.2392251","url":null,"abstract":"The Long-term Impact of Military-relevant Brain Injury Consortium-Military and Tactical Athlete Research Study (LIMBIC MATARS) program established in 2020 is comprised of 22 universities and health systems across the United States. The LIMBIC MATARS Consortium's goal is to increase understanding of the complexities of concussion in collegiate athletes by leveraging extant retrospective and novel prospective data sets through the application of innovative research designs. The manuscripts in this special issue represent findings from clinical data sets based on consensus-derived common data elements collected from the 2015-2016 to 2019-2020 sport seasons that include 1311 cases of collegiate athletes diagnosed with concussion. Using these data, LIMBIC MATARS investigators addressed hypotheses that included (1) factors, including access to athletic trainers, biological sex, and ADHD, that may influence recovery from concussion, (2) predisposing risks associated with reinjury after return-to-sport, such as sport type, and (3) therapeutic targets for intervention including language barriers, physical activity, return-to-learn, and sleep. This commentary introduces the methodology and 10 descriptive studies highlighting initial findings from the Consortium.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"85-87"},"PeriodicalIF":1.5,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding of head injury assessment and return to play processes and associated factors in United States Major League Rugby players. 了解美国橄榄球大联盟球员头部受伤评估和重返赛场过程及相关因素。

IF 1.5 4区医学

Brain injury Pub Date : 2025-01-28 Epub Date: 2024-10-02 DOI: 10.1080/02699052.2024.2408563

Owen M Sheehy, Katherine J Hunzinger, Christine M Baugh, Julie M Stamm

{"title":"Understanding of head injury assessment and return to play processes and associated factors in United States Major League Rugby players.","authors":"Owen M Sheehy, Katherine J Hunzinger, Christine M Baugh, Julie M Stamm","doi":"10.1080/02699052.2024.2408563","DOIUrl":"10.1080/02699052.2024.2408563","url":null,"abstract":"Objectives: Evaluate professional rugby players' self-reported perceived understanding of the head injury assessment (HIA) and return to play (RTP) processes and determine factors related to understanding and trust pertaining to these processes.Methods: An electronic survey measured concepts of interest. A thematic analysis of player understanding was performed, and player statements were coded.Results: 207 U.S. Major League Rugby (MLR) players participated (26.7 ± 3.4 years). HIA and RTP protocol understanding was not correlated with concussion history (p = 0.41). International rugby experience and trust regarding MLR support of the following protocols and opposing team medical staff practices varied in their relationship to HIA understanding. Trust that all MLR teams follow the same protocols was positively correlated with all HIA questions (ps < 0.03). No HIA questions were correlated with trust in their own team's medical staff. All trust questions were significantly correlated with RTP process understanding. Qualitative analysis identified four HIA- and RTP-related themes: education needs, staffing needs, HIA criticisms, and importance of player safety.Conclusion: International playing experience and greater trust in the MLR and league stakeholders were associated with greater player understanding of the HIA and RTP protocols. These results provide insight into the importance of educating players on league-specific concussion protocols.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"99-107"},"PeriodicalIF":1.5,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in depression symptoms over 10 years after TBI; a long-term prospective study. 创伤性脑损伤 10 年后抑郁症状的变化；一项长期前瞻性研究。

IF 1.5 4区医学

Brain injury Pub Date : 2025-01-28 Epub Date: 2024-10-13 DOI: 10.1080/02699052.2024.2413639

Rajiv K Singh, Thomas J Humphries, Jeremy F Dawson, Julia Tiupin-Szulc, Suzanne Mason, Fiona E Lecky

{"title":"Changes in depression symptoms over 10 years after TBI; a long-term prospective study.","authors":"Rajiv K Singh, Thomas J Humphries, Jeremy F Dawson, Julia Tiupin-Szulc, Suzanne Mason, Fiona E Lecky","doi":"10.1080/02699052.2024.2413639","DOIUrl":"10.1080/02699052.2024.2413639","url":null,"abstract":"Objective: Evaluate the prevalence and risk factors associated with depression symptoms at 10 years after traumatic brain injury (TBI) and compare with results at 10 weeks and 1 year.Methods: A large cohort of prospective admissions with TBI were followed up for 10 years. Depression using HADS (Hospital Anxiety and Depression Scale) score > 8 was measured. Several injury and demographic features were examined for association with depression.Results: Over 4 years, 1130 individuals were recruited of whom 916 attended at 1 year; after 10 years, 552 attended and 210 had died. 154 (17%) of the cohort was lost to follow-up. The prevalence of depression at 10 weeks was 56.3% [95%CI 52.2-60.5], at 1 year was 42.4% [95%CI 38.3-46.5] and 10 years 38.4% [95%CI 34.3-42.5]. There was considerable change in individual scores over time in both directions. A multivariable analysis identified the independent predictors of 10-year depression score as lower GCS, social deprivation, female gender, past psychiatric history, alcohol intoxication and unemployment. Age, ethnicity, social support, TBI etiology, CT abnormality and medical comorbidity were insignificant.Conclusions: While the overall level of symptoms at 10-year post-TBI remains high, there is considerable change in individual depression status over time. The predictors identified may allow the targeting of vulnerable sub-populations.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"154-161"},"PeriodicalIF":1.5,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survival and clinical characteristics of patients with disorders of consciousness in a developing country between 2002 and 2018. 一个发展中国家 2002 年至 2018 年意识障碍患者的存活率和临床特征。

IF 1.5 4区医学

Brain injury Pub Date : 2025-01-28 Epub Date: 2024-10-16 DOI: 10.1080/02699052.2024.2409357

Viviana Cornejo-Suil, Gonzalo Rivera-Lillo, Rodrigo Melo-Martínez, Felipe Covarrubias-Escudero, Nicolás Marín-Godoy, Rodrigo Torres-Castro

{"title":"Survival and clinical characteristics of patients with disorders of consciousness in a developing country between 2002 and 2018.","authors":"Viviana Cornejo-Suil, Gonzalo Rivera-Lillo, Rodrigo Melo-Martínez, Felipe Covarrubias-Escudero, Nicolás Marín-Godoy, Rodrigo Torres-Castro","doi":"10.1080/02699052.2024.2409357","DOIUrl":"10.1080/02699052.2024.2409357","url":null,"abstract":"Objective: Describe the survival, sociodemographic and clinical characteristics of subjects with disorders of consciousness in a reference rehabilitation center, in a developing country.Methods: Patients with disorders of consciousness (DoC) caused by acquired neurological injuries, admitted between the years 2002-2018 in a neurorehabilitation center. Extracted data covered demographics, clinical details, survival time, and discharge information. Cox proportional hazard model and Kaplan-Meier analysis were used to reveal, associations with survival.Result: Out of 5064 neurological cases, 159 patients were diagnosed with DoC. The demographic data showed a male dominance (65%), with an average injury age of 42 years. The most common causes were traumatic (41%), anoxic (36%), and vascular (10%), with traffic accidents accounting for 71% of traumatic injuries. The study found that 75% of patients remained in a vegetative state (VS), and 25% in a minimally conscious state (MCS), with an average survival of 2110 days.Conclusion: There were no significant differences in survival days between patients in MCS and VS. Patients with traumatic injuries showed a higher survival rate than those with non-traumatic injuries. Age and etiology were identified as factors associated with a higher risk of death.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"118-125"},"PeriodicalIF":1.5,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rasch analysis of the depression anxiety stress scales-21 (DASS-21) in a mild traumatic brain injury sample. 对轻度脑外伤样本中的抑郁焦虑压力量表-21（DASS-21）进行 Rasch 分析。

IF 1.5 4区医学

Brain injury Pub Date : 2025-01-28 Epub Date: 2024-10-07 DOI: 10.1080/02699052.2024.2411297

Josh W Faulkner, Deborah L Snell, R J Siegert

{"title":"Rasch analysis of the depression anxiety stress scales-21 (DASS-21) in a mild traumatic brain injury sample.","authors":"Josh W Faulkner, Deborah L Snell, R J Siegert","doi":"10.1080/02699052.2024.2411297","DOIUrl":"10.1080/02699052.2024.2411297","url":null,"abstract":"Objective: In this study, we evaluated the psychometric properties of the Depression Anxiety Stress Scales 21 items (DASS-21) in a mild traumatic brain injury (mTBI) sample.Method: Treatment-seeking adults (n = 347) were recruited from outpatient rehabilitation services in New Zealand. Dimensionality, reliability, person separation index, and differential item functioning (DIF) of the DASS-21 were examined using Rasch analysis.Results: Initial analysis of the complete 21-item DASS showed poor overall fit due to problems with individual items. Fit to the Rasch model was excellent when treated as three composite scores. The stress subscale demonstrated adequate model fit, dimensionality and good reliability. For anxiety, fit was not good, reliability was unsatisfactory and DIF was evident on one item. When this item was removed, fit to the model was still inadequate as was reliability. DIF was also evident for depression, but when this item was removed, fit to the model was adequate.Conclusion: The DASS-21 is a psychometrically sound measure of distress and stress for adults seeking treatment following mTBI. Ordinal to interval score conversion tables are provided to increase the precision of measurement. When assessing depression in a mTBI population, a 6-item depression subscale is recommended. Caution is advised in using the DASS-21 anxiety subscale alone.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"136-144"},"PeriodicalIF":1.5,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adverse childhood experiences and brain injury in younger children: Findings from the 2021-2022 National Survey of Children's Health. 年幼儿童的不良童年经历和脑损伤：2021-2022 年全国儿童健康调查的结果。

IF 1.5 4区医学

Brain injury Pub Date : 2025-01-28 Epub Date: 2024-10-09 DOI: 10.1080/02699052.2024.2411292

Jessica Salley Riccardi, Molly Hale

{"title":"Adverse childhood experiences and brain injury in younger children: Findings from the 2021-2022 National Survey of Children's Health.","authors":"Jessica Salley Riccardi, Molly Hale","doi":"10.1080/02699052.2024.2411292","DOIUrl":"10.1080/02699052.2024.2411292","url":null,"abstract":"Purpose: The purpose of this study was to extend on previous research finding by investigating adverse childhood experiences (ACEs) and brain injury in children younger than 12 years old.Methods: A total of 58,601 US children under 12 years old were included in the 2020-2021 National Survey of Children's Health, a self-reported national survey administered to caregivers.Results: ACEs were significantly associated with increased risk for unconfirmed (χ2 (55891, 55904) = 141.84, p < 0.001, R2 = .03) and confirmed brain injury, χ2 (56481, 56494) = 508.28, p < 0.001, R2 = .05 when accounting for demographic characteristics. The association between ACEs and brain injury was not contingent on sports involvement; females not involved in sports had the strongest association between ACEs and brain injury (χ2 (10938, 10951) = 99.40, p < 0.001, R2 = .03) compared to sports-involved females and males. For children under 12 years old with brain injury, the relations between experiencing at least one ACE and health and educational outcomes were significant for all health and educational outcomes (p < 0.001).Conclusions: Caregiver education on and screening for brain injury in families experiencing ACEs would likely support more timely identification and management of co-occurring brain injury in this population. Further research is needed to identify prevention, assessment, and management strategies that would be specifically beneficial to children at risk for co-occurring brain injury and ACEs to improve health and educational outcomes.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"126-135"},"PeriodicalIF":1.5,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Galantamine combined with cognitive rehabilitation on post-stroke cognitive impairment: a proof-of-concept study. 加兰他敏联合认知康复治疗脑卒中后认知障碍：概念验证研究。

IF 1.5 4区医学

Brain injury Pub Date : 2025-01-28 Epub Date: 2024-10-03 DOI: 10.1080/02699052.2024.2409355

Mélanie Planton, Federico Nemmi, Berengère Pages, Jean-François Albucher, Nicolas Raposo, Lola Danet, Patrice Péran, Jérémie Pariente

{"title":"Galantamine combined with cognitive rehabilitation on post-stroke cognitive impairment: a proof-of-concept study.","authors":"Mélanie Planton, Federico Nemmi, Berengère Pages, Jean-François Albucher, Nicolas Raposo, Lola Danet, Patrice Péran, Jérémie Pariente","doi":"10.1080/02699052.2024.2409355","DOIUrl":"10.1080/02699052.2024.2409355","url":null,"abstract":"Purpose: We conducted a proof-of-concept study to evaluate the effects of galantamine treatment versus placebo combined to cognitive rehabilitation (CR) after stroke.Materials and methods: In this 12-week, double blinded, randomized, controlled trial, patients were assigned to either combined approach of galantamine and CR (G-CR) or placebo and CR (P-CR). Primary outcome was the proportion of patients who crossed over from vascular cognitive disorder (VCD) to no-VCD at 12 weeks. Secondary outcomes included changes in cognition, mood, quality of life and the N-back fMRI paradigm, assessed at baseline, 6 and 12 weeks and after an 8-week washout period.Results: Ten patients were allocated to G-RC group, 12 to the P-RC group. After 12 weeks, 40.1% of all patients converted to no-VCD with similar proportions between groups. Both groups showed improvements in episodic and working memory, executive and quality of life after 6 weeks of CR. Decreased depression and anxiety were noted, and all benefits persisted after the washout period. An interaction effect was observed in the right parietal lobule during the N-back task.Conclusions: Interventions lead to improved cognition and distinct cortical reorganization without being able to establish correlation between neural changes and behavioral measures.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"108-117"},"PeriodicalIF":1.5,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0