Brain injury最新文献_第8页

Cerebral ischemia-reperfusion induces the expression of phoenixin receptor (GPR173) and adult neurogenesis marker proteins in the rat striatum. 脑缺血再灌注诱导大鼠纹状体中凤凰素受体（GPR173）和成体神经发生标志蛋白的表达。

IF 1.5 4区医学

Brain injury Pub Date : 2025-05-12 Epub Date: 2024-12-29 DOI: 10.1080/02699052.2024.2443004

Kinga Mordecka-Chamera, Artur Pałasz, Aleksandra Suszka-Świtek, Katarzyna Bogus, Władysław Skałba, Aneta Piwowarczyk-Nowak, John J Worthington, Marta Pukowiec, Veerta Sharma, Łukasz Filipczyk

{"title":"Cerebral ischemia-reperfusion induces the expression of phoenixin receptor (GPR173) and adult neurogenesis marker proteins in the rat striatum.","authors":"Kinga Mordecka-Chamera, Artur Pałasz, Aleksandra Suszka-Świtek, Katarzyna Bogus, Władysław Skałba, Aneta Piwowarczyk-Nowak, John J Worthington, Marta Pukowiec, Veerta Sharma, Łukasz Filipczyk","doi":"10.1080/02699052.2024.2443004","DOIUrl":"https://doi.org/10.1080/02699052.2024.2443004","url":null,"abstract":"Objective: Brain ischemia is considered an extremely potent stress factor at the cellular and molecular level which may lead to massive neuronal death. Alternatively, short brain ischemia and reperfusion (I/R) can actually stimulate neurogenesis, angiogenesis and peptidergic signaling. There is little known about the potential effect of I/R on brain expression of the novel neuropeptide; phoenixin (PNX) and its receptor GPR173.Methods: The study was carried out on adult male Wistar rats divided into seven groups: control, sham operation and 5 ischemic experimental groups across the time course of reperfusion. We examined mRNA and protein expression of GPR173 and neurogenesis markers Musashi-1, doublecortin (DCX), and Sox-2 in the striatum.Results: GPR-173 positive cells were found only in the ischemic hemisphere, where Musashi-1, DCX and Sox-2-positive cells were also observed. Gene expression analysis also showed a significant increase of GPR-173 mRNA level in the I/R striatum in comparison with the control one. Results confirm previous findings suggesting that I/R stimulates adult neurogenesis in the striatum and affects peptidergic signaling in this structure.Conclusions: A very fast occurence of GPR-173 expression revealed in the striatum may potentially be exclusively related to neuroprotective neurochemical changes that occur in this region after I/R.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":"39 6","pages":"457-463"},"PeriodicalIF":1.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acoustic neuromodulation with or without micro-voltage tACS reduces post-concussive symptoms. 有或没有微电压tACS的听神经调节可减少脑震荡后症状。

IF 1.5 4区医学

Brain injury Pub Date : 2025-05-12 Epub Date: 2025-02-06 DOI: 10.1080/02699052.2024.2445709

Catherine L Tegeler, Thaddeus J Haight, Wesley R Cole, Hossam A Shaltout, Y Sammy Choi, Tyler E Harris, Nora Rachels, Paula G Bellini, Michael J Roy, Charles H Tegeler

{"title":"Acoustic neuromodulation with or without micro-voltage tACS reduces post-concussive symptoms.","authors":"Catherine L Tegeler, Thaddeus J Haight, Wesley R Cole, Hossam A Shaltout, Y Sammy Choi, Tyler E Harris, Nora Rachels, Paula G Bellini, Michael J Roy, Charles H Tegeler","doi":"10.1080/02699052.2024.2445709","DOIUrl":"10.1080/02699052.2024.2445709","url":null,"abstract":"Objective: Persistent post-concussive symptoms (PPCS) are common and disruptive, particularly in military service members (SM), yet there are no approved therapies targeting underlying physiological processes. This study was designed to compare acoustic neuromodulation using Cereset Research™ Standard Operating Procedures (CR-SOP), with Cereset Research Cranial Electrical Stimulation (CR-CES), on PPCS.Methods: SM, veterans, or dependents with PPCS (Neurobehavioral Symptom Inventory [NSI] Score ≥23) were randomized to receive 10 sessions of engineered tones linked to brainwaves (CR-SOP) or 5 sessions of CR-CES, which adds intermittent low voltage transcranial alternating current stimulation (tACS) to CR-SOP. Designed to assess non-inferiority between varied doses of CR-SOP and CR-CES, the primary outcome was a change in post-concussive symptoms on the NSI, with secondary outcomes of heart rate variability (HRV) and self-report measures of PTSD, sleep, headaches, and depression.Results: Among study participants (n = 80, 21.3% female, mean age 40.2 [SD 13.2], 4.8 deployments, 3.2 TBIs), mean NSI declined from 45.6 to 29.5 after intervention (p < 0.0001), with gains sustained at 3 months (29.7). No significant between group differences for NSI (CR-SOP: baseline 43.9, post-intervention 26.0, 3-month 27.2, and CR-CES 46.4, 30.7, and 31.1, respectively), and no evidence of inferiority between the groups with respect to NSI. Similar improvements were seen on PCL-5, ISI, HIT-6, and PHQ-9, with no HRV differences between groups.Conclusion: Both acoustic neuromodulation alone (CR-SOP) and a lower dose of CR-SOP, with tACS added (CR-CES), significantly improved PPCS out to 3 months.Registration: ClinicalTrials.gov - NCT03649958.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"496-508"},"PeriodicalIF":1.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of severe traumatic brain injury with human bone marrow mesenchymal stem cell extracellular vesicles: a case report. 人骨髓间充质干细胞胞外囊泡治疗重型颅脑外伤1例。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-21 Epub Date: 2025-01-01 DOI: 10.1080/02699052.2024.2432967

Thomas S Nabity, John T Ransom

{"title":"Treatment of severe traumatic brain injury with human bone marrow mesenchymal stem cell extracellular vesicles: a case report.","authors":"Thomas S Nabity, John T Ransom","doi":"10.1080/02699052.2024.2432967","DOIUrl":"10.1080/02699052.2024.2432967","url":null,"abstract":"Objective: Extracellular vesicles (EVs) derived from regenerative mesenchymal stem cells might safely treat traumatic brain injury (TBI). We evaluated the safety and efficacy of a human bone marrow derived mesenchymal stem cell EVs (hBM-MSC EV) investigational product (IP) in a patient with severe TBI.Design: A single case study employing an IP with a strong safety profile in over 200 patients.Method: The patient was dosed intravenously three times/week in the first week of six successive months. Functional Independence Measure (FIM) and Functional Assessment Measure (FAM) were performed to quantify effects. Safety monitoring was performed every week for nine months.Results: No adverse events occurred. Within eight weeks FIM and FAM scores improved by 48-55% and were sustained for the entire 36 weeks. All specific outcome items assessed by FIM and FAM that were initially low showed sustained improvements ranging from 41% to 233%, with the greatest improvements seen in locomotion, mobility and cognitive function.Conclusion: After moderate improvement with conventional therapy, the substantial improvement observed following introduction of the IP suggests that hBM-MSC EVs may offer a novel and safe means to improve TBI patient outcomes. Appropriate randomized, controlled clinical trials to conclusively evaluate this therapeutic option are indicated.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"330-335"},"PeriodicalIF":1.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Gender matters": the development of infographics to raise awareness and promote gender-transformative care in traumatic brain injury. "性别问题"：制作信息图表，以提高对脑外伤的认识，并促进性别转变护理。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-21 Epub Date: 2024-11-21 DOI: 10.1080/02699052.2024.2429698

Thaisa Tylinski Sant'Ana, Alina Rodrigues, Farrah Schwartz, Angela Colantonio, Tatyana Mollayeva

{"title":"\"Gender matters\": the development of infographics to raise awareness and promote gender-transformative care in traumatic brain injury.","authors":"Thaisa Tylinski Sant'Ana, Alina Rodrigues, Farrah Schwartz, Angela Colantonio, Tatyana Mollayeva","doi":"10.1080/02699052.2024.2429698","DOIUrl":"10.1080/02699052.2024.2429698","url":null,"abstract":"Purpose: To develop a series of infographics providing persons with traumatic brain injury (TBI) and their circle of care with evidence-based information on sex and gender topics in TBI.Materials and methods: We employed an iterative participatory design engaging knowledge users, scientists, and experts in brain injury and patient education. To inform infographic content, we conducted an information needs assessment with knowledge users through semi-structured interviews and referred to our previously published evidence syntheses on TBI topics. We followed principles of graphic design and science communication to create materials reflecting lived experiences of knowledge users.Results: We created a series of infographics with actionable messages and visual representations of evidence-based information. We achieved a Flesch Reading-Ease score of 60.1, corresponding to a Grade 7/8 reading level. The infographics met the color contrast criteria of the Web Content Accessibility Guidelines. Knowledge users found the material useful, visually appealing, and helpful in understanding complex topics.Conclusions: There is value in merging art and science to develop educational materials that meet the unique information needs of knowledge users. Iterative participatory design engaging diverse stakeholders is essential for co-creating knowledge translation tools to improve access to health information and quality of care after TBI.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"300-311"},"PeriodicalIF":1.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical complications and advance medical decision-making in the minimally conscious state. 微意识状态下的医疗并发症和预先医疗决策。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-21 Epub Date: 2024-11-12 DOI: 10.1080/02699052.2024.2425737

Berno U H Overbeek, Willemijn S van Erp, Henk J Eilander, Raymond T C M Koopmans, Jan C M Lavrijsen

{"title":"Medical complications and advance medical decision-making in the minimally conscious state.","authors":"Berno U H Overbeek, Willemijn S van Erp, Henk J Eilander, Raymond T C M Koopmans, Jan C M Lavrijsen","doi":"10.1080/02699052.2024.2425737","DOIUrl":"10.1080/02699052.2024.2425737","url":null,"abstract":"Objectives: Medical complications occur frequently in MCS and influence advance medical decision-making. This study aimed to report on medical complications and advance medical decision-making in a nationwide group of MCS patients.Methods: In this descriptive cross-sectional study, clinical and advance medical decision-making characteristics were collected in a survey, completed by the treating physician.Results: The MCS population consisted of 32 patients: 65.6% traumatic etiology, 68.8% male. Patients had a median of five complications: hypertonia/spasticity (81.3%) and pneumonia (50.0%) occurred most frequently. Most patients had curative goals: three patients had a fully curative treatment scenarios, 29 a curative scenario with ≥ 1 treatment restrictions, two a palliative and two a symptomatic scenario. Conversations about advance medical decision-making were complicated by disputes with next of kin, inability to evaluate medical treatment because of medical instability, next of kin not being ready to discuss medical treatment, or a treatment scenario explicitly based on requests of next of kin.Conclusion: Medical complications are common in MCS patients and advance medical decision making was complicated. This legitimates realization of specialized care across acute, post-acute and long-term care. Further longitudinal research into advance medical decision-making is recommended.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"249-256"},"PeriodicalIF":1.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding 'quality' in adult traumatic brain injury rehabilitation from the perspectives of different stakeholders: a participatory mixed methods study. 从不同利益相关者的角度理解成人脑外伤康复的 "质量"：一项参与式混合方法研究。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-21 Epub Date: 2024-11-16 DOI: 10.1080/02699052.2024.2425743

Carolyn Murray, Anthea Worley, Julie Luker, Susan Hillier

{"title":"Understanding 'quality' in adult traumatic brain injury rehabilitation from the perspectives of different stakeholders: a participatory mixed methods study.","authors":"Carolyn Murray, Anthea Worley, Julie Luker, Susan Hillier","doi":"10.1080/02699052.2024.2425743","DOIUrl":"10.1080/02699052.2024.2425743","url":null,"abstract":"Primary objective: The purpose of this study was to explore how 'quality' is understood for traumatic brain injury (TBI) rehabilitation from the perspectives of the rehabilitation recipients, their families and the providing clinicians.Research design: A participatory study using a mixed-methods, triangulation design.Methods: The study involved 1. a systematic literature search; 2. Individual semi-structured interviews with people with TBI and/or their caregivers and TBI rehabilitation clinicians, and 3. an online consensus process.Outcomes and results: 22 participants (7 people with TBI, 8 caregivers, 7 clinicians) participated in individual interviews. Their transcribed data were coded into broad categories via in-depth reflexive, thematic analysis; these categories were then mapped to 13 quality domains extracted from the literature. The emergent themes were then presented to the individuals, via an electronic consensus tool in two rounds. This resulted in 12 prioritized domains of quality that encompass service features, staff qualities and effectiveness.Conclusion: These evidence-informed and consensus-agreed indicators for quality may help guide both the provision and evaluation of TBI rehabilitation, that is valued and meaningful.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"257-266"},"PeriodicalIF":1.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Responding to the ongoing pandemic-related challenges of individuals with brain injury through the perspective of community-service in Canada: A qualitative study. 通过加拿大社区服务的视角应对脑损伤患者当前面临的与大流行病相关的挑战：定性研究。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-21 Epub Date: 2024-11-16 DOI: 10.1080/02699052.2024.2426683

Ana Paula Salazar, Sophie Lecours, Lisa Engel, Monique A M Gignac, Shlomit Rotenberg, Sareh Zarshenas, Michelle McDonald, Emily Nalder, Carolina Bottari

{"title":"Responding to the ongoing pandemic-related challenges of individuals with brain injury through the perspective of community-service in Canada: A qualitative study.","authors":"Ana Paula Salazar, Sophie Lecours, Lisa Engel, Monique A M Gignac, Shlomit Rotenberg, Sareh Zarshenas, Michelle McDonald, Emily Nalder, Carolina Bottari","doi":"10.1080/02699052.2024.2426683","DOIUrl":"10.1080/02699052.2024.2426683","url":null,"abstract":"Objective: To investigate brain injury (BI) associations' perspectives regarding the impacts of the second year of the COVID-19 pandemic on individuals with BI and BI associations services across Canada.Methods: This qualitative descriptive study included 26 representatives of Canadian BI associations that participated in six online focus groups to discuss the effects of the second year of the pandemic on clients living with BI and on the provision of community services.Results: Findings revealed three main themes: 1) ongoing pandemic-related challenges faced by clients living with BI, including worsening mental health and basic needs insecurities, difficulties faced by clients in adhering to safety measures, and ongoing technological issues; 2) ongoing adaptations to accommodate clients' needs, including offering tailored services, ensuring consistent and transparent safety measures, and providing hybrid services; and 3) developing a sustainable 'new normal' aligned with association mandates and resources by expanding networks and building resilience.Conclusion: The unfolding of the pandemic has brought increased challenges for people with BI and reinforced the need for adapted, clear, and accessible public health information to ensure the safety of vulnerable populations in times of crisis. It is essential to bolster community-based associations that provide direct care to people with BI.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"267-276"},"PeriodicalIF":1.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of influencing factors for postoperative brain injury in patients with cardiac surgery. 心脏手术患者术后脑损伤影响因素分析。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-21 Epub Date: 2024-12-06 DOI: 10.1080/02699052.2024.2430386

Weifang Xu, Xiaolan Ma, Chen Zhang

{"title":"Analysis of influencing factors for postoperative brain injury in patients with cardiac surgery.","authors":"Weifang Xu, Xiaolan Ma, Chen Zhang","doi":"10.1080/02699052.2024.2430386","DOIUrl":"10.1080/02699052.2024.2430386","url":null,"abstract":"Objective: To identify risk factors in people with heart disease prior to undergoing cardiac surgery and to provide a prediction model.Methods: 106 patients who underwent cardiac surgery were selected by convenience sampling method. Case-control study design was used to divide them into control and observation groups according to whether there was postoperative brain injury. General demographic data, perioperative surgery, postoperative recovery, past medical history and preoperative conditions, laboratory test indicators were collected. Univariate and multivariate Logistic regression analyses were performed to select influencing factors. A nomogram model for predicting postoperative brain injury was established.Results: Univariate Logistic regression analysis showed that age, female, stroke, diabetes mellitus, perioperative administration of dexmedetomidine, intraoperative use of cardiopulmonary bypass were related factors for postoperative brain injury(p < 0.05). Multivariate Logistic regression analysis showed that females, history of stroke, and intraoperative use of cardiopulmonary bypass were risk factors, and perioperative administration of dexmedetomidine was protective factor(p < 0.05). Nomogram model was established with an AUC of 0.847 and accuracy of 84.7%.Conclusion: Preoperative stroke history and females are risk factors for brain injury after coronary artery bypass grafting under cardiopulmonary bypass, and perioperative use of dexmedetomidine is protective factor.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"320-329"},"PeriodicalIF":1.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cross-season analysis of S100B as a potential marker of concussion in professional rugby players. S100B作为职业橄榄球运动员脑震荡潜在标志的跨赛季分析。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-21 Epub Date: 2024-12-02 DOI: 10.1080/02699052.2024.2429700

Áine M Kelly, Clíodhna McHugh, James Hale, Joice Cunningham, Noreen Boyle, Oisín Joyce, Brendan O'Connell, Gareth Farrell, Fiona Wilson

{"title":"A cross-season analysis of S100B as a potential marker of concussion in professional rugby players.","authors":"Áine M Kelly, Clíodhna McHugh, James Hale, Joice Cunningham, Noreen Boyle, Oisín Joyce, Brendan O'Connell, Gareth Farrell, Fiona Wilson","doi":"10.1080/02699052.2024.2429700","DOIUrl":"10.1080/02699052.2024.2429700","url":null,"abstract":"Objectives: To investigate the effect of multiple seasons of play on serum S100B concentration in male professional rugby players, while also assessing the acute effects following a season of play and concussion.Methods: A prospective study of professional male rugby players over three seasons (2016/17 to 2018/19) was conducted. Serum sampling was carried out during pre-season, post-season and following a concussion; sustained during match play at a home game (between 2-24hrs), during each season. Serum S100B concentrations were determined by ELISA assay.Results: Fourteen players sustained 24 concussions over three seasons, of which 13 samples (54%) were collected. Pre- and post-season serum S100B remained stable across multiple seasons. S100B concentration increased significantly following concussion compared with pre-season (p = 0.002) and post-season (p = 0.009), reflective in a 3.23-fold-change post-concussion, with no difference found between pre- and post-season values. S100B concentration measured at post-season was not significantly different for players who had a concussion during a season and players who did not.Conclusion: S100B remains stable across multiple seasons of play in professional rugby players. As concussion results in a temporary increase in S100B concentration, returning to pre-season values by post-season, S100B may be a useful diagnostic marker for improving existing management protocols for sports-related concussions.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"312-319"},"PeriodicalIF":1.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dodecafluoropentane improves neuro-behavioral outcomes and return of spontaneous circulation rate in a swine model of cardiac arrest. 十二氟戊烷可改善猪心脏骤停模型的神经行为结果和自发性循环恢复率。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-21 Epub Date: 2024-11-21 DOI: 10.1080/02699052.2024.2427803

Travis W Murphy, Robert J Cueto, Jiepei Zhu, Jacob Milling, Justin Sauter, Muna Oli, Ian T Griffin, Gagan Midathala, J Adrian Tyndall, Bruce Spiess, Kevin K W Wang, Firas H Kobeissy, Torben K Becker

{"title":"Dodecafluoropentane improves neuro-behavioral outcomes and return of spontaneous circulation rate in a swine model of cardiac arrest.","authors":"Travis W Murphy, Robert J Cueto, Jiepei Zhu, Jacob Milling, Justin Sauter, Muna Oli, Ian T Griffin, Gagan Midathala, J Adrian Tyndall, Bruce Spiess, Kevin K W Wang, Firas H Kobeissy, Torben K Becker","doi":"10.1080/02699052.2024.2427803","DOIUrl":"10.1080/02699052.2024.2427803","url":null,"abstract":"Introduction: Dodecafluoropentane emulsion (DDFPe) administration has previously demonstrated improved gas exchange in single-organ perfusion models. This could translate to prevention of brain injury in cardiac arrest.Methods: We induced cardiac arrest in 12 pigs, performing CPR after 5-minute downtime. Pigs were randomly assigned to DDFPe (n = 7) or saline placebo (n = 5) groups. Neurologic injury biomarkers were measured at baseline, after return of spontaneous circulation (ROSC), and every 24 hours in survivors. Blinded Neurological Alertness Score, Neurological Dysfunction Score, and Overall Performance Score was performed in addition to histopathological scoring of parietal and hippocampal sections.Results: One placebo and four DDFPe pigs survived the 96-hour observation period. The odds ratio for ROSC was 7.2 (p = 0.22). Survival odds ratio was 4.6 (p = 0.29). All surviving animals had impaired motor responses that recovered by 72 hours. DDFPe animals showed better neuro-behavioral scores than placebo.Conclusion: The findings of this novel study provide a proof of concept and early signal toward efficacy of intravenous DDFPe in cardiac arrest. The trend toward improved ROSC and functional survival may reflect improved microcirculatory gas exchange in DDFPe animals. Improving gas exchange in brain microcirculation during resuscitation from cardiac arrest may provide a significant therapeutic benefit.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"277-285"},"PeriodicalIF":1.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0