Áine M Kelly, Clíodhna McHugh, James Hale, Joice Cunningham, Noreen Boyle, Oisín Joyce, Brendan O'Connell, Gareth Farrell, Fiona Wilson
{"title":"S100B作为职业橄榄球运动员脑震荡潜在标志的跨赛季分析。","authors":"Áine M Kelly, Clíodhna McHugh, James Hale, Joice Cunningham, Noreen Boyle, Oisín Joyce, Brendan O'Connell, Gareth Farrell, Fiona Wilson","doi":"10.1080/02699052.2024.2429700","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effect of multiple seasons of play on serum S100B concentration in male professional rugby players, while also assessing the acute effects following a season of play and concussion.</p><p><strong>Methods: </strong>A prospective study of professional male rugby players over three seasons (2016/17 to 2018/19) was conducted. Serum sampling was carried out during pre-season, post-season and following a concussion; sustained during match play at a home game (between 2-24hrs), during each season. Serum S100B concentrations were determined by ELISA assay.</p><p><strong>Results: </strong>Fourteen players sustained 24 concussions over three seasons, of which 13 samples (54%) were collected. Pre- and post-season serum S100B remained stable across multiple seasons. S100B concentration increased significantly following concussion compared with pre-season (<i>p</i> = 0.002) and post-season (<i>p</i> = 0.009), reflective in a 3.23-fold-change post-concussion, with no difference found between pre- and post-season values. S100B concentration measured at post-season was not significantly different for players who had a concussion during a season and players who did not.</p><p><strong>Conclusion: </strong>S100B remains stable across multiple seasons of play in professional rugby players. As concussion results in a temporary increase in S100B concentration, returning to pre-season values by post-season, S100B may be a useful diagnostic marker for improving existing management protocols for sports-related concussions.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"312-319"},"PeriodicalIF":1.5000,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A cross-season analysis of S100B as a potential marker of concussion in professional rugby players.\",\"authors\":\"Áine M Kelly, Clíodhna McHugh, James Hale, Joice Cunningham, Noreen Boyle, Oisín Joyce, Brendan O'Connell, Gareth Farrell, Fiona Wilson\",\"doi\":\"10.1080/02699052.2024.2429700\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>To investigate the effect of multiple seasons of play on serum S100B concentration in male professional rugby players, while also assessing the acute effects following a season of play and concussion.</p><p><strong>Methods: </strong>A prospective study of professional male rugby players over three seasons (2016/17 to 2018/19) was conducted. Serum sampling was carried out during pre-season, post-season and following a concussion; sustained during match play at a home game (between 2-24hrs), during each season. Serum S100B concentrations were determined by ELISA assay.</p><p><strong>Results: </strong>Fourteen players sustained 24 concussions over three seasons, of which 13 samples (54%) were collected. Pre- and post-season serum S100B remained stable across multiple seasons. S100B concentration increased significantly following concussion compared with pre-season (<i>p</i> = 0.002) and post-season (<i>p</i> = 0.009), reflective in a 3.23-fold-change post-concussion, with no difference found between pre- and post-season values. S100B concentration measured at post-season was not significantly different for players who had a concussion during a season and players who did not.</p><p><strong>Conclusion: </strong>S100B remains stable across multiple seasons of play in professional rugby players. As concussion results in a temporary increase in S100B concentration, returning to pre-season values by post-season, S100B may be a useful diagnostic marker for improving existing management protocols for sports-related concussions.</p>\",\"PeriodicalId\":9082,\"journal\":{\"name\":\"Brain injury\",\"volume\":\" \",\"pages\":\"312-319\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-03-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brain injury\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/02699052.2024.2429700\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/2 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain injury","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/02699052.2024.2429700","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/2 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
A cross-season analysis of S100B as a potential marker of concussion in professional rugby players.
Objectives: To investigate the effect of multiple seasons of play on serum S100B concentration in male professional rugby players, while also assessing the acute effects following a season of play and concussion.
Methods: A prospective study of professional male rugby players over three seasons (2016/17 to 2018/19) was conducted. Serum sampling was carried out during pre-season, post-season and following a concussion; sustained during match play at a home game (between 2-24hrs), during each season. Serum S100B concentrations were determined by ELISA assay.
Results: Fourteen players sustained 24 concussions over three seasons, of which 13 samples (54%) were collected. Pre- and post-season serum S100B remained stable across multiple seasons. S100B concentration increased significantly following concussion compared with pre-season (p = 0.002) and post-season (p = 0.009), reflective in a 3.23-fold-change post-concussion, with no difference found between pre- and post-season values. S100B concentration measured at post-season was not significantly different for players who had a concussion during a season and players who did not.
Conclusion: S100B remains stable across multiple seasons of play in professional rugby players. As concussion results in a temporary increase in S100B concentration, returning to pre-season values by post-season, S100B may be a useful diagnostic marker for improving existing management protocols for sports-related concussions.
期刊介绍：
Brain Injury publishes critical information relating to research and clinical practice, adult and pediatric populations. The journal covers a full range of relevant topics relating to clinical, translational, and basic science research. Manuscripts address emergency and acute medical care, acute and post-acute rehabilitation, family and vocational issues, and long-term supports. Coverage includes assessment and interventions for functional, communication, neurological and psychological disorders.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
