Brain injuryPub Date : 2025-03-01Epub Date: 2024-12-17DOI: 10.1080/02699052.2024.2441846
Jacob I McPherson, Andrew Nowak, Haley Chizuk, John J Leddy, Mohammad N Haider
{"title":"Differing clinical characteristics among individuals with concussions sustained at work, in motor vehicle collisions, and sport.","authors":"Jacob I McPherson, Andrew Nowak, Haley Chizuk, John J Leddy, Mohammad N Haider","doi":"10.1080/02699052.2024.2441846","DOIUrl":"10.1080/02699052.2024.2441846","url":null,"abstract":"<p><strong>Purpose: </strong>To compare clinical characteristics in patients with concussions sustained by prevalent, but understudied, mechanisms (work-related concussion [WRC] and motor vehicle collision [MVC]-related concussion) to sport-related concussion (SRC).</p><p><strong>Methods: </strong>Retrospective review of 281 electronic medical records from an outpatient concussion clinic. Time since injury (days), duration of care (days), amount of care (number of visits), and perceived health (Short-Form 12) were collected.</p><p><strong>Results: </strong>The time between injury and clinic presentation was significantly greater in WRC and MVC-related concussion compared to SRC. These groups were also older, had a longer duration of care, required more referrals for outside clinical services, and reported worse perceived mental and physical health versus SRC.</p><p><strong>Conclusion: </strong>These results suggest that clinical courses may be significantly different for individuals with SRC, WRC and MVC-related concussion, and that different management approaches and expectations may be necessary for these groups. Further research is indicated.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"420-426"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The neuroprotective potential of carbazole in traumatic brain injury.","authors":"Akashdeep Singh Pathania, Kavita Badhai, Nirmal Singh, Dimple Sethi Chopra, Dhandeep Singh","doi":"10.1080/02699052.2024.2441843","DOIUrl":"10.1080/02699052.2024.2441843","url":null,"abstract":"<p><strong>Objective: </strong>To review the neuroprotective potential of carbazole and its derivatives in the management of traumatic brain injury (TBI), focusing on their mechanisms of action, preclinical findings, and potential clinical applications.</p><p><strong>Data sources: </strong>Relevant literature was identified through a comprehensive search of PubMed, Embase, Medline, Web of Science, and the Cochrane Library databases.</p><p><strong>Review methods: </strong>This review includes an analysis of studies investigating the neuroprotective properties of carbazole, emphasizing its anti-apoptotic, antioxidative, neurotrophic, and mitochondrial protective mechanisms. The scope of the review covers preclinical studies and explores future directions for clinical translation.</p><p><strong>Results: </strong>Carbazole compounds demonstrate significant neuroprotective effects by reducing oxidative stress, inhibiting apoptosis, and promoting neuroregeneration in preclinical models of TBI. These compounds also potentially preserve blood-brain barrier integrity and modulate inflammatory responses. However, clinical studies evaluating carbazole-based therapies in human subjects are limited, highlighting a critical gap in translational research.</p><p><strong>Conclusion: </strong>Carbazole and its derivatives are promising therapeutic agents for mitigating secondary damage and enhancing recovery in TBI. Further research is warranted to establish their efficacy and safety in clinical settings and to explore their potential as part of combination therapies for TBI management.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"359-369"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2025-03-01Epub Date: 2025-01-29DOI: 10.1080/02699052.2024.2443001
Karen Caeyenberghs, Mervyn Singh, Annalee L Cobden, Elizabeth G Ellis, Liam G Graeme, Priscilla Gates, Alex Burmester, Jade Guarnera, Jake Burnett, Evelyn M Deutscher, Lyndon Firman-Sadler, Bec Joyce, Jacqueline P Notarianni, Christian Pardo de Figueroa Flores, Juan F Domínguez D
{"title":"Magnetic resonance imaging in traumatic brain injury: a survey of clinical practitioners' experiences and views on current practice and obstacles.","authors":"Karen Caeyenberghs, Mervyn Singh, Annalee L Cobden, Elizabeth G Ellis, Liam G Graeme, Priscilla Gates, Alex Burmester, Jade Guarnera, Jake Burnett, Evelyn M Deutscher, Lyndon Firman-Sadler, Bec Joyce, Jacqueline P Notarianni, Christian Pardo de Figueroa Flores, Juan F Domínguez D","doi":"10.1080/02699052.2024.2443001","DOIUrl":"10.1080/02699052.2024.2443001","url":null,"abstract":"<p><strong>Introduction: </strong>Magnetic resonance imaging (MRI) has revolutionized our capacity to examine brain alterations in traumatic brain injury (TBI). However, little is known about the level of implementation of MRI techniques in clinical practice in TBI and associated obstacles.</p><p><strong>Methods: </strong>A diverse set of health professionals completed 19 multiple choice and free text survey questions.</p><p><strong>Results: </strong>Of the 81 respondents, 73.4% reported that they acquire/order MRI scans in TBI patients, and 66% indicated they would prefer MRI be more often used with this cohort. The greatest impediment for MRI usage was scanner availability (57.1%). Less than half of respondents (42.1%) indicated that they perform advanced MRI analysis. Factors such as dedicated experts within the team (44.4%) and user-friendly MRI analysis tools (40.7%), were listed as potentially helpful to implement advanced MRI analyses in clinical practice.</p><p><strong>Conclusion: </strong>Results suggest a wide variability in the purpose, timing, and composition of the scanning protocol of clinical MRI after TBI. Three recommendations are described to broaden implementation of MRI in clinical practice in TBI: 1) development of a standardized multimodal MRI protocol; 2) future directions for the use of advanced MRI analyses; 3) use of low-field MRI to overcome technical/practical issues with high-field MRI.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"427-443"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2025-03-01Epub Date: 2024-11-27DOI: 10.1080/02699052.2024.2433668
Gaoyi Li, Tao Peng, Jingquan Zhang
{"title":"Diagnostic significance of serum hsa_circ_0000745 and hsa_circ_0001459 in ischemic stroke and its role in the prognosis of interventional therapy.","authors":"Gaoyi Li, Tao Peng, Jingquan Zhang","doi":"10.1080/02699052.2024.2433668","DOIUrl":"10.1080/02699052.2024.2433668","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to identify hsa_circ_0000745 and hsa_circ_0001459 expression, value as biomarkers in ischemic stroke (IS), and functions in BV2 cells.</p><p><strong>Methods: </strong>RNA sequencing datasets in the GEO database were retrieved. The expression of circulating hsa_circ_0000745 and hsa_circ_0001459 was validated by RT-qPCR. The predictive values of hsa_circ_0000745 and hsa_circ_0001459 in the diagnosis and outcome of acute IS were evaluated using receiver operator characteristic curve analysis. BV2 cells were treated with lipopolysaccharide, followed by hsa_circ_0000745 or hsa_circ_0001459 downregulation and subsequent migration and apoptosis assay. The downstream miR-1287-5p was detected using the luciferase reporter gene assay.</p><p><strong>Results: </strong>Hsa_circ_0000745 or hsa_circ_0001459 were upregulated in acute IS. Hsa_circ_0000745 or/and hsa_circ_0001459 differentiated between healthy control subjects and patients with IS, resulting in areas under curve (AUC) of 0.85 and 0.83, respectively. Hsa_circ_0000745 or hsa_circ_0001459 was positively correlated with serum pro-inflammatory cytokines and the NIHSS (<i>P</i><0.001). Longitudinal and ROC analyses of hsa_circ_0001459 and hsa_circ_0000745 expression levels revealed the 90-day-outcome-predicting potential after stroke. Hsa_circ_0001459 and hsa_circ_0000745 promoted the apoptosis and inhibited the migration of LPS-induced BV2 cells. Hsa_circ_0001459 and hsa_circ_0000745 commonly sponged miR-1287-5p.</p><p><strong>Conclusions: </strong>Hsa_circ_0001459 and hsa_circ_0000745 showed upregulations in IS and might have clinical utility as a diagnostic and outcome-predicting marker.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"381-389"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2025-03-01Epub Date: 2024-12-04DOI: 10.1080/02699052.2024.2435947
Patrick S Ledwidge, Lindsey C Hartland, Chloe A Huston, Christa M Jones, Erin Neff, Elizabeth Castro, John P Abt
{"title":"Post-concussion changes in the N200 and P300 ERPs are associated with cognitive symptoms and performance.","authors":"Patrick S Ledwidge, Lindsey C Hartland, Chloe A Huston, Christa M Jones, Erin Neff, Elizabeth Castro, John P Abt","doi":"10.1080/02699052.2024.2435947","DOIUrl":"10.1080/02699052.2024.2435947","url":null,"abstract":"<p><strong>Purpose: </strong>To examine how post-concussion changes to the N200 and P300 event-related potentials (ERPs) are associated with cognitive symptoms and neurocognitive performance.</p><p><strong>Methods: </strong>High-density electroencephalography (EEG) was recorded during a Go/No-Go task from 16 young adults within one month after their concussion and 16 matched controls. Participants were also administered the Cognitive-Linguistic Quick Test (CLQT) and self-reported concussion-like symptoms. Mixed analysis of variance models compared the N200/P300 ERPs between concussion and control groups. Nested linear regressions examined associations between the N200/P300 ERPs and CLQT cognitive domains, cognitive symptom clusters, and total concussion symptoms, with particular interest in within-task changes in the N200/P300 ERPs (e.g. habituation).</p><p><strong>Results: </strong>N200 and P300 ERP amplitudes were associated with individual differences in cognitive outcomes after concussion. For concussion participants only, smaller P300 amplitudes were significantly associated with greater cognitive symptoms. When considering within-task changes in ERPs over repeated trial presentations, reduced habituation of N200 amplitudes was significantly associated with poorer attention and memory CLQT domain scores. Reduced habituation of P300 amplitudes was also associated with greater cognitive symptoms and total symptoms for concussion participants.</p><p><strong>Conclusion: </strong>Within-task changes in ERP dynamics supporting attention and executive control are associated with individual differences in cognitive outcomes after concussion.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"390-399"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2025-03-01Epub Date: 2024-12-08DOI: 10.1080/02699052.2024.2436594
Melanie H Vergeer, Leah J Mercier, Samantha J McIntosh, Chloe Boucher, Robyn F Madden, Jane Shearer, Chantel T Debert
{"title":"Characterizing supplement use and dietary behaviors in adults with acquired brain injury.","authors":"Melanie H Vergeer, Leah J Mercier, Samantha J McIntosh, Chloe Boucher, Robyn F Madden, Jane Shearer, Chantel T Debert","doi":"10.1080/02699052.2024.2436594","DOIUrl":"10.1080/02699052.2024.2436594","url":null,"abstract":"<p><strong>Background: </strong>Acquired brain injury (ABI) can result in persistent symptoms and lasting disability. Supplements are becoming more popular in patients with chronic symptoms; however, little is known about supplementation and dietary behaviors after ABI.</p><p><strong>Methods: </strong>In this cross-sectional observational study, questionnaires were collected from 211 adults with ABI presenting to outpatient brain injury clinics. The temporality of 54 unique supplements and 15 dietary behaviors were surveyed. Sources of information, reasons for use, side effects, and perceived safety were obtained.</p><p><strong>Results: </strong>After ABI, 55% of the participants increased supplement utilization by ≥1 supplement, resulting in 74% consuming supplements (3.8<b>±</b>4.1 unique supplements daily); Vitamin D, multivitamins, magnesium, and omega 3- and/or -6 were most commonly consumed. Healthcare professionals were the main source of information, as reported by 69% of the respondents. The primary reason for supplementation was following a recommendation by a healthcare professional (63%). Supplementation was widely considered safe (83%), and most participants (76%) did not experience side effects. The majority of participants (70%) did not adhere to specific dietary behaviors.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"410-419"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhancing ischemic stroke management: leveraging machine learning models for predicting patient recovery after Alteplase treatment.","authors":"Babak Khorsand, Atena Vaghf, Vahide Salimi, Maryam Zand, Seyed Abdolreza Ghoreishi","doi":"10.1080/02699052.2025.2472188","DOIUrl":"https://doi.org/10.1080/02699052.2025.2472188","url":null,"abstract":"<p><strong>Aim: </strong>Ischemic stroke remains a leading global cause of morbidity and mortality, emphasizing the need for timely treatment strategies. This study aimed to develop a machine learning model to predict clinical outcomes in ischemic stroke patients undergoing Alteplase therapy.</p><p><strong>Methods: </strong>Data from 457 ischemic stroke patients were analyzed, including 50 demographic, clinical, laboratory, and imaging variables. Five machine learning algorithms - k-nearest neighbors (KNN), support vector machines (SVM), Naïve Bayes (NB), decision trees (DT), and random forest (RF) - were applied for constructing models. Additional feature importance analysis were p to identify high-impact predictors.</p><p><strong>Results: </strong>The Random Forest model showed the highest predictive reliability, outperforming other algorithms in sensitivity (0.97 ± 0.02) and F-measure (0.96 ± 0.02). feature importance analysis identified NIH1C (LOC commands (eye and hand movements)), NIH1B (LOC questions (birthday and age recall)), and NIH_noValue (the absence of any stroke characteristics) as the most influential predictors. Using only the top-ranked features identified from the feature importance analysis, the model maintained comparable performance, suggesting a streamlined yet effective predictive approach.</p><p><strong>Conclusion: </strong>Our findings highlight the potential of machine learning in optimizing ischemic stroke treatment outcomes. Random Forest, in particular, proved effective as a decision-support tool, offering clinicians valuable insights for more tailored treatment approaches.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-7"},"PeriodicalIF":1.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain injuryPub Date : 2025-02-27DOI: 10.1080/02699052.2025.2469705
Nicholas W Sheets, Yan Shen, Jeneva M Garland, David S Plurad, Lori F Harbour, Alessandro Orlando, Samir M Fakhry
{"title":"Methamphetamine and traumatic brain injury outcomes: an analysis of 29,416 patients from the national trauma data bank.","authors":"Nicholas W Sheets, Yan Shen, Jeneva M Garland, David S Plurad, Lori F Harbour, Alessandro Orlando, Samir M Fakhry","doi":"10.1080/02699052.2025.2469705","DOIUrl":"https://doi.org/10.1080/02699052.2025.2469705","url":null,"abstract":"<p><strong>Background: </strong>Methamphetamine (Meth) use is rising in the US. Most research focuses on severe TBI, neglecting milder cases. We evaluated Meth's impact on patient outcomes and hospital resource use across all TBI severities.</p><p><strong>Methods: </strong>This study included National Trauma Data Bank (NTDB) patients from 2017-2019, aged 18-54, with near-isolated TBI, a drug screen, and negative blood alcohol. Meth+ patients were compared to Meth- patients on demographics, injury severity, and outcomes using χ² and Wilcoxon rank-sum tests.</p><p><strong>Results: </strong>Of 29,416 patients with TBI patients, 337 (1%) were Meth+. Meth+ patients had significantly higher ICU admissions (61% vs. 50%, <i>p</i> < 0.001), mechanical ventilation (32% vs. 22%, <i>p</i> < 0.001), and tracheostomy (7% vs. 4%, <i>p</i> < 0.008). Meth+ had longer hospital stays (median 4 vs. 3 days, <i>p</i> < 0.001) and higher cerebral monitor use (8% vs. 5%, <i>p</i> < 0.05). Mortality rates were similar (5% vs. 5%, <i>p</i> = 0.46). Meth+ patients had more preexisting mental health/personality (20% vs. 12%, <i>p</i> < 0.001) and substance use disorders (44% vs. 6%, <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Meth use in patients with near-isolated TBI patients is linked to greater injury severity, increased resource use, and longer hospital stays but does not significantly impact mortality. Targeted interventions are needed to manage clinical challenges and optimize resource utilization.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-8"},"PeriodicalIF":1.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sex differences in work-related traumatic brain injury: a concurrent mixed methods study employing the person-environment-occupation model.","authors":"Chung Hyun Yong, Sarah Trick, Thaisa Tylinski Sant'Ana, Angela Colantonio, Tatyana Mollayeva","doi":"10.1080/02699052.2024.2419948","DOIUrl":"10.1080/02699052.2024.2419948","url":null,"abstract":"<p><strong>Background: </strong>Work-related traumatic brain injury (wrTBI) is considered a critical injury that can be prevented. Few studies have integrated clinical data and workers' injury narratives to inform sex-specific wrTBI prevention.</p><p><strong>Objective: </strong>To examine sex differences in pre-injury factors and provide recommendations for primary prevention of wrTBI.</p><p><strong>Methods: </strong>Concurrent mixed methods study. The Person-Environment-Occupation (PEO) model served as a theoretical framework for qualitative and quantitative data analyses.</p><p><strong>Results: </strong>The sample consisted of 93 workers (51% female, 67% aged over 40) with wrTBI sustained as a result of being struck by/against an object (SBA, 46%), falls (30%), motor vehicle accident (13%), and assault (11%). Qualitative analysis of injury events revealed distinct patterns between male and female workers in the nature and physical/social load of occupational activities performed at the time of injury. Quantitative analysis enriched interpretation of observed sex differences across PEO factors. New insights emerged by stratifying SBA injury cases, revealing sex differences in Environment- and Occupation-related factors unique to workers struck by an object.</p><p><strong>Implications: </strong>Sex- and cause-specific analysis of injury events is essential for surveillance and prevention of wrTBI. Addressing fitness for duty, supervisor-worker relationships, and industry-specific hazards in prevention strategies is essential to ensure workplace safety.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"211-220"},"PeriodicalIF":1.5,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}