Brain injury最新文献

{"title":"Patients' perspectives on causal relations among consequences of acquired brain injury in a neuropsychiatric population: a proof-of-concept network analysis.","authors":"Karen de Waele, Brenda van den Broek, Caroline M van Heugten, Boudewijn A A Bus, Sophie J M Rijnen","doi":"10.1080/02699052.2026.2647400","DOIUrl":"10.1080/02699052.2026.2647400","url":null,"abstract":"<p><strong>Objectives: </strong>To explore perceived causal relations (PCRs) between aspects of mental functioning in individuals with ABI receiving care at a specialized neuropsychiatric facility.</p><p><strong>Methods: </strong>Fourteen individuals with ABI rated perceived causality between seven aspects of mental functioning (as outlined in the Brief International Classification of Functioning, Disability and Health (ICF) Core Sets for Traumatic Brain Injury and for Neurological Conditions for Post-Acute Care) during a guided interview. A visual network of PCRs was constructed based on these ratings, and centrality measures were computed.</p><p><strong>Results: </strong>Network analysis revealed strong PCRs among difficulties in energy and drive functions, emotional, and attention functions. Difficulties in energy and drive, as well as emotional functions, were perceived as central to the network, having the most pronounced influence on other aspects of mental functioning. In contrast, difficulties with attention functions were primarily perceived as caused by difficulties in other aspects of functioning.</p><p><strong>Conclusions: </strong>This study confirms proof-of-concept for the application of PCR methodology in individuals with ABI. Employing a network approach grounded in patients' self-reported perceptions to explore interconnections between consequences of ABI, provides unique insights into the lived experience of ABI. The findings suggest that addressing fatigue and emotional regulation may positively influence other symptoms.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"656-663"},"PeriodicalIF":1.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dutch La Trobe communication questionnaire (LCQ): cognitive pretesting and evaluation of content validity.","authors":"Carmen Verhoeks, Marielle Reijbroek, Brenda van den Broek, Boudewijn Bus, Indira Tendolkar, Jacinta Douglas, Sophie Rijnen","doi":"10.1080/02699052.2026.2647410","DOIUrl":"10.1080/02699052.2026.2647410","url":null,"abstract":"<p><strong>Background: </strong>Cognitive-communication disorders (CCDs) are common after acquired brain injury (ABI) and may adversely impact on different aspects of an individual's life. The La Trobe Communication Questionnaire (LCQ) is developed to measure perceived communicative ability after ABI from different perspectives. To date, no Dutch version of the LCQ is available.</p><p><strong>Objectives: </strong>To cognitively pretest the Dutch LCQ and to evaluate content validity.</p><p><strong>Materials and methods: </strong>The Dutch LCQ was pretested in a sample of 7 individuals with brain injury and 7 close-others using cognitive interviews. We obtained feedback on comprehensibility, comprehensiveness and relevance of the LCQ to evaluate content validity. In addition, participants were asked to rate the relevance of each item of the LCQ on a 5-point rating scale for the construct (i.e. CCDs), the target population (i.e. individuals with ABI), and the context of use (i.e. assessment of CCDs in individuals with ABI).</p><p><strong>Results: </strong>Adjustments were made to 10 questions to improve comprehensibility. All respondents declared that they did not miss key concepts of CCDs in the questionnaire. Mean relevance scores as assigned to the individual items of the LCQ by the respondents were all ≥ 3,5, which means that, according to individuals with brain injury and close-others, all items are relevant for the construct, the target population, and the context of use.</p><p><strong>Discussion: </strong>This study is a step toward improving the identification and management of CCDs in the Netherlands. In addition, the results of this study provide evidence for the content validity of the LCQ.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"664-673"},"PeriodicalIF":1.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractory hyponatremia solved through early cranioplasty after decompressive hemicraniectomy in a traumatic brain injury patient: a case report.","authors":"Maria Teresa Alvarado-Torres, Harold España Arrieta, Juan Sebastian Davidson, Alexandra Ramos-Márquez, Rafael De Avila Mercado","doi":"10.1080/02699052.2026.2632883","DOIUrl":"10.1080/02699052.2026.2632883","url":null,"abstract":"<p><strong>Background: </strong>Hyponatremia is a frequently encountered electrolyte disorder in neurocritical care patients, often associated with various types of brain injuries such as hemorrhages, ischemic events, tumors, infections, surgical procedures, and traumatic brain injury (TBI), among others.</p><p><strong>Case presentation: </strong>Herein, we present a case study of a patient with severe TBI who underwent decompressive craniectomy and subsequently developed persistent hyponatremia during the Intensive Care Unit (ICU) stay. Recognizing the crucial distinction between the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) and Cerebral Salt Wasting (CSW) syndrome is imperative, given the distinct treatment approaches required for each condition. The patient underwent ultra-early cranioplasty, which resulted in the subsequent resolution of hyponatremia and improvement in clinical status.</p><p><strong>Conclusion: </strong>We provide a comprehensive review of the management of hyponatremia in neurocritical patients, underscoring the efficacy of early cranioplasty as a therapeutic intervention.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"631-634"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146257037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progranulin alleviates cerebral ischemia-reperfusion-induced neuronal ferroptosis via regulating p-STAT3/HSPA5 signaling.","authors":"Guilong Su, Binru Li, Wanxing Lu, Zhengxiang Huang, Weidong Nong, Chun Luo","doi":"10.1080/02699052.2026.2638957","DOIUrl":"10.1080/02699052.2026.2638957","url":null,"abstract":"<p><strong>Introduction: </strong>Progranulin (PGRN) exerts neuroprotective effects. However, the roles of PGRN in cerebral ischemia/reperfusion (I/R) injury have not been reported.</p><p><strong>Objective: </strong>This study aimed to investigate the potentials of PGRN in cerebral ischemia injury.</p><p><strong>Methods: </strong>Middle cerebral artery occlusion/reperfusion (MCAO/R) surgery was used to establish mouse cerebral ischemia/reperfusion (I/R) injury model. Neuronal loss was detected using terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay. HT22 cells were exposed to oxygen-glucose deprivation/reoxygenation to establish an in vitro cerebral I/R model. Gene expression was detected using reverse transcription-quantitative PCR, immunofluorescence, and Western blot. Oxidative stress was detected using reactive oxygen species and malondialdehyde assays. Iron metabolism was detected using ferrous iron assay. Neuronal functions were determined using Cell Counting Kit-8 and propidium iodide staining assay. Signal transducer and activator of transcription 3 (STAT3) and heat shock protein family A member 5 (HSPA5) interaction was determined using dual-luciferase reporter and chromatin immunoprecipitation assays.</p><p><strong>Results: </strong>Cerebral I/R injury contributed to neuronal ferroptosis. PGRN was downregulated in cerebral I/R injury in vivo and in vitro, the overexpression of which inhibited oxidative stress and neuronal ferroptosis. PGRN promoted the hyperactivation of STAT3, which transcriptionally upregulated HSPA5 signaling. However, STAT3 knockdown abolished the effects of PGRN overexpression and promoted oxidative stress and neuronal ferroptosis.</p><p><strong>Conclusions: </strong>In summary, PGRN protected neurons from the cerebral I/R injury-induced ferroptosis via activating p-STAT3/HSPA5 signaling. Therefore, PGRN may be a therapeutic target for cerebral I/R injury.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"619-630"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leptin-induced neuroprotection in ischemic stroke: a comprehensive systematic review and meta-analysis elucidating molecular pathways in preclinical animal models.","authors":"Sedigheh Behrouzifar, Habibollah Esmaily","doi":"10.1080/02699052.2026.2636708","DOIUrl":"10.1080/02699052.2026.2636708","url":null,"abstract":"<p><strong>Aim: </strong>This systematic review and meta-analysis critically evaluates preclinical evidence on leptin's efficacy and mechanistic actions in rodent models of focal cerebral ischemia.</p><p><strong>Method: </strong>Comprehensive searches of PubMed, EMBASE, Scopus, and Google Scholar (1995-2024) identified 17 eligible studies (<i>n</i> = 1,383 animals), following PRISMA 2020 guidelines and PROSPERO registration (CRD42023461569). Data extraction and risk of bias assessment (SYRCLE tool) were conducted independently by dual reviewers. Pooled standardized mean differences (SMD) were calculated using a random-effects model.</p><p><strong>Results: </strong>Leptin administration significantly reduced infarct volume (SMD = -2.76; 95% CI: -3.65 to -1.86; <i>p</i> < 0.001) and ameliorated neurological deficits (SMD = -4.37; 95% CI: -5.80 to -2.95; <i>p</i> < 0.001), with pronounced effects in murine models. Mechanistically, leptin mitigated apoptosis - indicated by lowered cleaved Caspase-3 and TUNEL-positive cells - and promoted the upregulation of proteins involved in neuroprotection, including BCL-2, p-STAT, TRPV1, and the leptin receptor.</p><p><strong>Conclusion: </strong>Although this meta-analysis demonstrates the promising neuroprotective properties of leptin, the substantial heterogeneity among studies and the resulting lower certainty of evidence highlight the critical need for future research employing standardized methodologies, rigorous study designs, and sufficient statistical power to validate these findings and support their translation into clinical settings.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"566-584"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147316457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence, microbiology, and clinical impact of ventilator-associated pneumonia in traumatic brain injury: a single-center retrospective study.","authors":"Suleyman Kilinc, Mustafa Said Aydogan, Mehmet Duran, Cem Seyho Yucetas","doi":"10.1080/02699052.2026.2638955","DOIUrl":"10.1080/02699052.2026.2638955","url":null,"abstract":"<p><strong>Objective: </strong>Ventilator-associated pneumonia (VAP) is a frequent complication in patients with traumatic brain injury (TBI) requiring mechanical ventilation. This study aimed to evaluate the incidence, microbiological characteristics, and clinical impact of VAP in mechanically ventilated patients with TBI.</p><p><strong>Methods: </strong>During the 5-year study period, 565 patients with traumatic brain injury were screened; 340 met inclusion criteria and were included in the final analysis, divided into VAP (<i>n</i> = 170) and non-VAP (<i>n</i> = 170) groups. This retrospective observational study included adult patients with TBI who required invasive mechanical ventilation for ≥48 hours between January 2020 and December 2024. Patients with pneumonia at admission were excluded. VAP was diagnosed according to international guideline criteria using clinical, radiological, and microbiological findings. Demographic data, injury severity, microbiological results, and clinical outcomes were analyzed. Independent predictors of VAP and mortality were assessed using multivariate logistic regression and Cox proportional hazards models.</p><p><strong>Results: </strong>Among 340 mechanically ventilated patients with TBI, 170 (50%) developed VAP, with a median onset of 5 days. Gram-negative pathogens predominated, mainly Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae, with multidrug-resistant organisms accounting for 61% of isolates. VAP was associated with longer mechanical ventilation, prolonged intensive care unit stay, and higher mortality. Lower admission Glasgow Coma Scale scores, prolonged sedation exposure, and longer ventilation duration were independently associated with VAP. VAP remained an independent predictor of mortality.</p><p><strong>Conclusions: </strong>VAP is highly prevalent in mechanically ventilated patients with TBI and is associated with adverse clinical outcomes, underscoring the importance of effective prevention strategies.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"614-618"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whiteout sign on dSIR MRI: A case series highlighting symptom-associated white matter changes not observed on standard T₂-FLAIR.","authors":"Joshua P McGeown, Gil Newburn, Paul Condron, Samantha J Holdsworth, Tracy R Melzer, Miriam Scadeng, Eryn E Kwon, Daniel M Cornfeld, Graeme M Bydder","doi":"10.1080/02699052.2026.2637171","DOIUrl":"10.1080/02699052.2026.2637171","url":null,"abstract":"<p><strong>Introduction: </strong>Mild traumatic brain injury (mTBI) is common, and up to half of patients experience persistent symptoms, but conventional neuroimaging typically appears normal. Divided Subtracted Inversion Recovery (dSIR) is a new sequence with high sensitivity to white matter changes that may appear normal on standard imaging.</p><p><strong>Case presentation: </strong>We present a case series of three adolescent males with acute mTBI scanned with both T₂-FLAIR and dSIR. In all cases, T₂-FLAIR images were normal. In two symptomatic cases, dSIR demonstrated a 'whiteout sign,' with bilateral, symmetrical high signal in cerebral and cerebellar white matter. In one case, the whiteout sign was present at 21 hours post-injury and had largely resolved by 64 hours. The third patient showed no abnormality on dSIR, consistent with their asymptomatic clinical presentation. Across all three cases, dSIR findings corresponded to clinical symptom status at the time of scanning.</p><p><strong>Conclusion: </strong>These early observations suggest dSIR may provide a useful imaging marker of secondary brain responses to injury. Further studies are needed to determine the sensitivity, specificity, and clinical value of dSIR in the assessment of mTBI.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"635-642"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A feasibility study of a peer mentoring program for acquired brain injury.","authors":"Richard P G Morris, Blanca de Dios Perez, Shirley Thomas, Neil Coulson, Kathryn Radford","doi":"10.1080/02699052.2026.2634929","DOIUrl":"10.1080/02699052.2026.2634929","url":null,"abstract":"<p><strong>Introduction: </strong>Acquired brain injury (ABI) can lead to difficulties in activities of daily living and reduced participation. Few interventions have explored the treatment impact of peer mentoring for people with ABI. This study explored the feasibility and acceptability of a peer mentoring intervention (PAIRS).</p><p><strong>Methods: </strong>Mixed-methods feasibility study with post-intervention interviews. Feasibility was assessed regarding recruitment, retention, and intervention adherence. Acceptability was assessed through post-intervention interviews with mentors, mentees, carers, and healthcare professionals. Effectiveness was assessed using descriptive statistics on quality of life, mood, and goal attainment. Interviews were analyzed using the framework method.</p><p><strong>Results: </strong>Four mentor-mentee pairs completed an introductory meeting, and between one and six further meetings. Three carers and five healthcare providers were recruited. More resources, such as improved staffing levels, would have improved recruitment rates. Carers showed reductions in carer burden. Interviews showed that participants valued the social contact provided by mentoring and reported some benefits to quality of life and adaptations to the effects of brain injury. However, they experienced difficulties arranging meetings.</p><p><strong>Conclusion: </strong>Peer mentoring was challenging and resource-intensive, suggesting a larger effectiveness study using the methods employed here is not feasible. Future studies should address matching procedures, implementation barriers, and consider alternative outcomes.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"585-597"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-dependent efficacy and safety of hypertonic saline versus mannitol in pediatric traumatic brain injury: a systematic review and meta-analysis.","authors":"Mohammed Alsabri, Shree Rath, Yahya A Mahmoud, Abdalla M Hadhoud, Eslam Abady, Ameer Hassoun, Eric Lusinski","doi":"10.1080/02699052.2026.2634095","DOIUrl":"10.1080/02699052.2026.2634095","url":null,"abstract":"<p><strong>Background: </strong>Traumatic brain injury (TBI) represents a significant cause of morbidity and mortality in children, with secondary injuries such as elevated intracranial pressure (ICP) significantly impacting outcomes. Hyperosmolar therapy is a cornerstone of acute management, with hypertonic saline (HTS) and mannitol as principal agents; however, comparative evidence regarding their efficacy and safety in pediatric populations remains inconclusive.</p><p><strong>Methods: </strong>Comprehensive searches of PubMed, Embase, and CENTRAL were performed up to June 2025. Primary outcomes were ICP reduction and all-cause mortality; secondary outcomes included neurological outcomes, adverse events, ICU/hospital stay, and physiological parameters. Meta-analyses employed random-effects models to pool risk ratios (RR), mean differences (MD), and proportions with 95% confidence intervals (CI).</p><p><strong>Results: </strong>A total of 14 studies, including 680 pediatric patients with TBI, were analyzed. HTS was associated with an increase in serum sodium (mean change 5.47 mEq/L; 95% CI: 1.30-9.64), severe hypernatremia (37%; on resolving heterogeneity rose to 53%), acute kidney injury (2.1%), and acute respiratory distress syndrome (4.5%). Comparative meta-analysis revealed no significant difference in mortality between HTS and mannitol (RR = 0.78; 95% CI: 0.50-1.23) and similar survival rates (RR = 1.05; 95% CI: 0.96-1.14), with high certainty. The pooled mortality rate for HTS was 17% (95% CI: 11%-24%), and survival was 83% (95% CI: 76%-89%). Pooled HTS analyses demonstrated a time-dependent decrease in ICP: 17.35 mmHg at 30 minutes, 9.72 mmHg at 60 minutes, and 8.45 mmHg at 24 hours. No significant differences were found for cerebral perfusion pressure (CPP) at 24 hours, ICU stay, hospital stay, or mechanical ventilation duration.</p><p><strong>Conclusion: </strong>In pediatric TBI, hypertonic saline and mannitol provide comparable efficacy for ICP reduction and mortality, with HTS demonstrating rapid ICP lowering and manageable safety signals. While HTS is generally well tolerated, further high-quality multicenter RCTs with standardized protocols and long-term outcomes are needed to clarify its clinical advantages over mannitol.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"539-557"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"History of TBI increases VA service use frequency among Veterans experiencing homelessness: a national examination.","authors":"Ryan Holliday, Emily R Edwards, Lisa A Brenner","doi":"10.1080/02699052.2026.2635661","DOIUrl":"10.1080/02699052.2026.2635661","url":null,"abstract":"<p><strong>Background: </strong>Veterans experiencing homelessness are clinically complex, often requiring myriad Department of Veterans Affairs (VA) services to manage their health and social service needs. Conditions common among these Veterans, including traumatic brain injury (TBI), may impact their VA service use; nonetheless, examination of the intersection of TBI and service use among Veterans experiencing homelessness remains understudied.</p><p><strong>Method: </strong>Electronic medical record data for 1,088,328 Veterans identified as experiencing homelessness who were accessing Veterans Health Administration (VHA) services from 2005 to 2024 were examined. Crude and adjusted models were conducted to examine VA service use based on documented TBI diagnosis.</p><p><strong>Results: </strong>In total, 12.7% of Veterans experiencing homelessness had a documented TBI diagnosis. TBI diagnosis was associated with increased frequency across all VHA service use settings. Associations appeared most robust in VA rehabilitative, mental health, and emergency service settings.</p><p><strong>Conclusions: </strong>Veterans experiencing homelessness with TBI histories appear to access several VHA services to manage their health and social service needs. Given this, interdisciplinary approaches (e.g. VA Homeless Patient Aligned Care Teams) are likely pragmatic for these Veterans. Further dissemination and evaluation of the utility of brain health-informed care within novel VHA service settings (e.g. justice programs, emergency services) may hold merit.</p>","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"598-602"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147316505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}