Brain injury最新文献_第6页

Understanding factors influencing exercise program adherence for youth with persistent post-concussive symptoms (PPCS). 了解影响有持续性脑震荡后症状（PPCS）的青少年坚持运动计划的因素。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-21 Epub Date: 2024-11-19 DOI: 10.1080/02699052.2024.2428404

Beth J Bollinger, Sara Pd Chrisman, Jordan Sahlberg, Jason A Mendoza, Tonya M Palermo, Chuan Zhou, M Alison Brooks, Frederick P Rivara, Payton Pedersen, Emily Prentice, Colby Hansen

{"title":"Understanding factors influencing exercise program adherence for youth with persistent post-concussive symptoms (PPCS).","authors":"Beth J Bollinger, Sara Pd Chrisman, Jordan Sahlberg, Jason A Mendoza, Tonya M Palermo, Chuan Zhou, M Alison Brooks, Frederick P Rivara, Payton Pedersen, Emily Prentice, Colby Hansen","doi":"10.1080/02699052.2024.2428404","DOIUrl":"10.1080/02699052.2024.2428404","url":null,"abstract":"Background: A significant portion of youth sustain a concussion every year, with around 30% experiencing persistent post-concussion symptoms (PPCS). Research has shown exercising just below the exertion level that provokes symptoms can lead to more rapid recovery. However, youth often struggle to adhere to exercise recommendations following concussion.Methods: We conducted structured qualitative interviews (n = 32) with concussed youth and their parents to examine factors influencing motivation to engage in exercise post-concussion. Questions were framed through the lens of Self-Determination Theory (SDT) and Thematic Analysis was used to code and analyze transcripts.Results: Four primary factors appeared to motivate youth to exercise after receiving a concussion: 1) social support, 2) accountability, 3) goal setting, and 4) structure. Utilizing the lens of SDT, one could theorize that including social support and accountability helped fulfill the need of relatedness, setting goals helped fulfill the need of autonomy, and providing program structure helped fulfill the need for competence.Conclusions: Our results suggest that Self-Determination Theory may be a useful frame for examining exercise adherence post-concussion. Incorporating social support, accountability, goal setting and structure could increase the effectiveness of exercise prescription post-concussion and should be the focus of further study.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"286-299"},"PeriodicalIF":1.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Significant initial hyperglycemia in young children with intracranial hemorrhage related to abuse. 与虐待相关的颅内出血的幼儿显著的初始高血糖。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-14 DOI: 10.1080/02699052.2025.2478417

Melanie M Randall, Christine L S Lee, Colleen Walsh Lang, Luke R Sampson, Brian G Chen, Lance A Brown

{"title":"Significant initial hyperglycemia in young children with intracranial hemorrhage related to abuse.","authors":"Melanie M Randall, Christine L S Lee, Colleen Walsh Lang, Luke R Sampson, Brian G Chen, Lance A Brown","doi":"10.1080/02699052.2025.2478417","DOIUrl":"https://doi.org/10.1080/02699052.2025.2478417","url":null,"abstract":"Introduction: Abusive head injury is more common in younger children, with long lasting physical or neurologic impairments seen in many survivors. There is a close relationship between hyperglycemia and head injury, with hyperglycemia associated with worse outcomes. Our hypothesis is that abusive head injury patients are more likely to have significant hyperglycemia.Methods: This study is a retrospective review of pediatric emergency department patients less than three years with traumatic intracranial hemorrhage. Demographics, laboratory values, and imaging results were recorded.Results: In total, 179 patients were analyzed. The median initial glucose for abuse patients was 164 mg/dL. The median initial glucose for non-abuse patients was 99 mg/dL. Eight patients had glucose levels greater than 300 mg/dL. All of these patients were abuse victims. The initial glucose level was significant for the diagnosis of child abuse, ICU admission, need for neurosurgical intervention, and mortality.Discussion: Young children with intracranial hemorrhage and initial glucose levels greater than 300 mg/dL were all found to be abuse victims. A very high initial glucose can prompt a provider to evaluate for abusive head injury. In cases of a sick infant with glucose greater than 300 mg/dl, the consideration of abuse should play a prominent role in the differential.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-4"},"PeriodicalIF":1.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A child who suffered from HSV encephalitis and AE with positive anti-MOG results: a case report. 儿童患有HSV脑炎和AE，抗mog结果阳性：1例报告。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-14 DOI: 10.1080/02699052.2025.2478431

Xilong Chen, Shixia Yue, Bin Yan, Taining Zhang, Bingying Zhou, Weikai Wang

{"title":"A child who suffered from HSV encephalitis and AE with positive anti-MOG results: a case report.","authors":"Xilong Chen, Shixia Yue, Bin Yan, Taining Zhang, Bingying Zhou, Weikai Wang","doi":"10.1080/02699052.2025.2478431","DOIUrl":"https://doi.org/10.1080/02699052.2025.2478431","url":null,"abstract":"Objective: To investigate the clinical manifestations of a pediatric case involving herpes simplex virus (HSV) encephalitis concurrent with autoimmune encephalitis (AE), which is characterized by a positive anti-myelin oligodendrocyte glycoprotein (MOG) antibody status.Results: A 12-year-old girl initially presented with symptoms of autoimmune encephalitis, including weakness and poor appetite, followed by headache, dizziness, and personality changes, which are indicative of disease progression. Cerebrospinal fluid routine biochemical tests demonstrated abnormal results. Cerebrospinal fluid mNGS results demonstrated human herpesvirus type I, and autoimmune encephalitis antibody tests suggested a positive result for anti-myelin oligodendrocyte glycoprotein (MOG) antibodies (1:100). Brain MRI revealed abnormal signals in the bilateral frontal lobes and dorsal thalamus. Therefore, diagnoses of herpes simplex virus encephalitis and autoimmune encephalitis were determined. After treatment with acyclovir, gamma globulin and hormones, the patient exhibited significant improvement in her symptoms.Conclusions: Children with herpes simplex virus encephalitis combined with autoimmune encephalitis may present with atypical clinical symptoms, and a positive anti-MOG antibody test is rarely observed, with no previous reports on this occurrence. The early detection of the relevant pathogens (in addition to timely reevaluation) can aid in accurate diagnosis. Moreover, antiviral and immunosuppressive therapy may significantly improve symptoms and patient prognosis.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-4"},"PeriodicalIF":1.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Consideration of evidence-based training content to strengthen coach recognition of concussion during youth sports activities. 考虑循证训练内容加强青少年体育运动中教练员对脑震荡的认知。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-11 DOI: 10.1080/02699052.2025.2469706

Ann Guernon, Paul M Wright, Beverly W Henry, Kendra Jorgensen-Wagers, Jennifer A Weaver, Christina Papadimitriou

{"title":"Consideration of evidence-based training content to strengthen coach recognition of concussion during youth sports activities.","authors":"Ann Guernon, Paul M Wright, Beverly W Henry, Kendra Jorgensen-Wagers, Jennifer A Weaver, Christina Papadimitriou","doi":"10.1080/02699052.2025.2469706","DOIUrl":"https://doi.org/10.1080/02699052.2025.2469706","url":null,"abstract":"Objective: To synthesize requirements and recommendations addressing sport-related concussion (SRC).Design: Qualitative study.Setting: Scholastic and non-scholastic athletic programs.Participants/materials: Coaches of youth 18 years and under, select Midwest state SRC laws, cross-section of athletic organizational policies and published concussion guidelines/position statements.Data collection and analysis: Data was collected and analyzed using deductive and inductive qualitative analysis framed around the categories of education and training, removal from play and return to play. Methods for each data source varied based on the nature of the information reviewed.Results: A comprehensive list of 44 elements relevant for youth coaches to strengthen sideline decisions (STRIDES) in recognition of SRC signs during sport.Conclusions: The STRIDES provides synthesized recommendations targeting content relevant to supporting coach recognition of SRC signs. The STRIDES is intended as a guide to develop or refine tools for effective implementation of evidence-based practices for sideline decision makers, such as coaches, who do not have medical professionals available at the time of decision-making. STRIDES is not intended to replace the medical professional but, rather, to support the knowledge and skills of coaches to recognize signs of SRC and make informed decisions about sport participation and referral to a medical professional.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-17"},"PeriodicalIF":1.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of aerobic exercise on concussion-related symptoms: a systematic review of randomized controlled trials. 有氧运动对脑震荡相关症状的影响：随机对照试验的系统回顾

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-10 DOI: 10.1080/02699052.2025.2476494

Anas R Alashram

{"title":"Effects of aerobic exercise on concussion-related symptoms: a systematic review of randomized controlled trials.","authors":"Anas R Alashram","doi":"10.1080/02699052.2025.2476494","DOIUrl":"https://doi.org/10.1080/02699052.2025.2476494","url":null,"abstract":"Background: A concussion is a head injury that temporarily affects the brain and results in various symptoms affecting an individual's functioning. Aerobic exercise has the potential to aid in recovery after traumatic brain injury. This systematic review aims to investigate the effects of independent aerobic exercise on concussion-related symptoms, define the appropriate timing and optimal treatment parameters, and provide future recommendations for future research.Methods: 'PubMed, SCOPUS, CINAHL, MEDLINE, EMBASE, and Web of Science' databases were searched from inception to February 15, 2024. The methodological quality of the studies included was judged using the 'Cochrane Collaboration tool.'Results: In total, nine randomized controlled trials (n = 346), with 45% of participants being females, were involved in this analysis. Seven studies were classified as having 'high' quality, and two were categorized as 'moderate' quality according to the 'Cochrane Collaboration tool.' High-to-moderate-intensity aerobic exercise may improve concussion-related symptoms, especially if administered early in the acute stage of concussion.Conclusions: The evidence supporting aerobic exercise for concussion-related symptoms is promising. Starting aerobic exercise when patients are medically stable might improve concussion-related symptoms. Regular supervised 20-minute high-to-moderate-intensity aerobic exercise sessions, 3-5 times a week in a safe and controlled environment, may alleviate concussion-related symptoms.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanism of HDAC2 regulating Nrf2 acetylation level in neuronal ferroptosis of neonatal rats with hypoxic-ischemic brain injury. HDAC2调控Nrf2乙酰化水平在缺氧缺血性脑损伤新生大鼠神经元铁凋亡中的作用机制

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-10 DOI: 10.1080/02699052.2025.2468309

Xin Liu, Xuwei Tao, Zhen Xiong, Huizhen Wang, Linkong Zeng

{"title":"Mechanism of HDAC2 regulating Nrf2 acetylation level in neuronal ferroptosis of neonatal rats with hypoxic-ischemic brain injury.","authors":"Xin Liu, Xuwei Tao, Zhen Xiong, Huizhen Wang, Linkong Zeng","doi":"10.1080/02699052.2025.2468309","DOIUrl":"https://doi.org/10.1080/02699052.2025.2468309","url":null,"abstract":"Objective: We investigated the mechanism of histone deacetylase 2 (HDAC2) modulating nuclear factor erythroid 2-related factor 2 (Nrf2) acetylation level in neuronal ferroptosis of hypoxic-ischemic brain injury (HIBI) neonatal rats.Methods: The pathological damage and neuronal injury in the hippocampal CA1 region of HIBI neonatal rat models were assessed by HE and Nissl staining. Levels of neuron-specific enolase (NSE), glutathione peroxidase 4 (GPX4), HDAC2, Nrf2, glutathione (GSH), reactive oxygen species (ROS), malondialdehyde (MDA), active Fe2+, Nrf2 acetylation, and nuclear Nrf2 in hippocampal tissues were determined.Results: HIBI induced upregulation of HDAC2 expression, causing hippocampal neuronal ferroptosis in neonatal rats, as evidenced by dissolved hippocampal CA1 region, neuronatrophy, reduced number of neurons, abated NSE and GPX4 levels, decreased NeuN+/GPX4+ cells, diminished GSH level, and increased levels of ROS, MDA and active Fe2+. Inhibition of HDAC2 partially ameliorated neuronal ferroptosis in HIBI neonatal rats. HDAC2 regulated Nrf2 expression and repressed Nrf2 nuclear translocation by mediating Nrf2 deacetylation. Inhibition of Nrf2 partially reversed the ameliorative effect of HDAC2 on neuronal ferroptosis in HIBI neonatal rats.Conclusion: HDAC2 modulated neuronal ferroptosis in HIBI neonatal rats by mediating Nrf2 deacetylation.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-11"},"PeriodicalIF":1.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors impacting mortality and withdrawal of life sustaining therapy in severe traumatic brain injury. 影响重型创伤性脑损伤患者死亡率和停止生命维持治疗的因素。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-04 DOI: 10.1080/02699052.2025.2472197

Varun Mishra, Jennifer Bath, Ellen Harvey, Melissa Martinez, Justin Weppner

{"title":"Factors impacting mortality and withdrawal of life sustaining therapy in severe traumatic brain injury.","authors":"Varun Mishra, Jennifer Bath, Ellen Harvey, Melissa Martinez, Justin Weppner","doi":"10.1080/02699052.2025.2472197","DOIUrl":"https://doi.org/10.1080/02699052.2025.2472197","url":null,"abstract":"Objective: To evaluate the correlation between withdrawal of life-sustaining therapy (WLST) and established prognostic indicators, as well as identify additional factors that may influence the timing of WLST.Methods: This retrospective case-control study examined adult patients admitted between 8/1/18 and 7/31/21 with severe TBI. A case group of 164 individuals who underwent WLST after TBI was matched 1:1 to a control group of 164 individuals with TBI who did not undergo WLST. Clinical indicators of poor prognosis were recorded, and functional recovery of control subjects was evaluated using Glasgow Outcome Scale Extended (GOSE).Results: The study involved 328 individuals (66 ± 19.9 years). Significant findings revealed lower GCS scores and shorter hospital stays in the case group compared to controls. Bilaterally absent pupillary responses were more common in cases (54.8%) and associated with shorter time to WLST and poorer functional outcomes in controls. Palliative care consultations and DNR code status were associated with time to WLST and functional outcomes. Non-geriatric control patients had better functional outcomes at follow-up (GOSE 6.3 ± 1.7) than geriatric patients (3.1 ± 1.5).Conclusions: These findings emphasize the importance of standardized guidelines, objective indicators, and avoiding nihilism in making WLST decisions as many control subjects achieved functional recovery at varying levels of independence.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-8"},"PeriodicalIF":1.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What are the views of those participating in a trial investigating acute post-traumatic benign paroxysmal positional vertigo? A qualitative study. 参与一项调查急性创伤后良性阵发性位置性眩晕的试验的人有什么看法？定性研究。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-01 Epub Date: 2024-12-03 DOI: 10.1080/02699052.2024.2435952

Rebecca M Smith, Bithi Sahu, Caroline Burgess, Jenna Beattie, Abby Newdick, Vassilios Tahtis, Jonathan Marsden, Barry M Seemungal

{"title":"What are the views of those participating in a trial investigating acute post-traumatic benign paroxysmal positional vertigo? A qualitative study.","authors":"Rebecca M Smith, Bithi Sahu, Caroline Burgess, Jenna Beattie, Abby Newdick, Vassilios Tahtis, Jonathan Marsden, Barry M Seemungal","doi":"10.1080/02699052.2024.2435952","DOIUrl":"10.1080/02699052.2024.2435952","url":null,"abstract":"Objective: The purpose of this study was to explore the experiences of patients and healthcare professionals participating in a randomized feasibility trial exploring the management of acute post-traumatic benign paroxysmal positional vertigo (BPPV), and to establish the acceptability and tolerability of BPPV assessment and treatment procedures.Methods: This was a multi-center qualitative study nested within a wider randomized feasibility trial. Purposive sampling was used to gather a cohort of healthcare professionals and patients from three major trauma centres in London, UK. Data were gathered using semi-structured interviews and were analyzed using Framework analysis.Results: Fifteen healthcare professionals and 26 patients participated. Patients and healthcare professionals reported acute BPPV diagnosis was acceptable and practicable. However, divergence was noted regarding views of randomization. Participants proposed several research delivery and protocol modifications for a future trial, including changes to study design and outcome measures.Conclusions: Healthcare professionals and patients participating in a multi-center qualitative study felt post-traumatic BPPV was feasible and acceptable to diagnose and treat acutely. Findings from this study will enhance the content and delivery of a future trial and may assist in influencing the development of clinical practice guidelines.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"400-409"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case management for acquired brain injury: a systematic review of the evidence base. 后天性脑损伤的病例管理：证据基础的系统回顾。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-01 Epub Date: 2024-12-10 DOI: 10.1080/02699052.2024.2438785

Rachel Leonard, Mark A Linden, Mark Holloway

{"title":"Case management for acquired brain injury: a systematic review of the evidence base.","authors":"Rachel Leonard, Mark A Linden, Mark Holloway","doi":"10.1080/02699052.2024.2438785","DOIUrl":"10.1080/02699052.2024.2438785","url":null,"abstract":"Background: Brain Injury Case management involves coordinating and organizing services and systems around people with acquired brain injuries' and their families. This review aimed to answer the question: What is the current available evidence for the use of case management in supporting survivors of ABI?Methods: Searches were conducted in seven databases (Medline (all), CINAHL, Embase, PsychInfo, Scopus, Web of Science, and PubMed), using a search strategy based on key terms: 'case management' and 'brain injury.' Quality of studies was assessed by the Mixed Methods Assessment Tool (MMAT), and the Joanna Briggs Institute (JBI) checklists. Findings were presented narratively.Results: A narrative synthesis of 35 included studies highlighted the challenges of measuring and evaluating the impact of case management for brain injury, vital aspects of case management, such as good communication and relationships, supporting the wider family, and case management across the continuum of care.Conclusions: Case managers play a pivotal role in the support and rehabilitation of people with ABI. The rapid evolution of case management has resulted in some challenges, such as lack of regulatory oversight and governance, and lack of standardization in treatment approaches. Future progression requires collaboration to produce better outcomes for clients and their families.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"337-358"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of puerarin combined with bone marrow mesenchymal stem cells on nerve injury in rats with ischemic stroke. 葛根素联合骨髓间充质干细胞对缺血性脑卒中大鼠神经损伤的保护作用。

IF 1.5 4区医学

Brain injury Pub Date : 2025-03-01 Epub Date: 2024-11-28 DOI: 10.1080/02699052.2024.2433667

Jiane Chen, Xiaoli Wu, Dongliang Nie, Zhimin Yu

{"title":"Protective effects of puerarin combined with bone marrow mesenchymal stem cells on nerve injury in rats with ischemic stroke.","authors":"Jiane Chen, Xiaoli Wu, Dongliang Nie, Zhimin Yu","doi":"10.1080/02699052.2024.2433667","DOIUrl":"10.1080/02699052.2024.2433667","url":null,"abstract":"Background: Bone marrow mesenchymal stem cells (BM-MSCs) transplantation shows promise for treating ischemic stroke, but the ischemic environment that follows cerebral infarction hinders the survival of transplanted cells. We aimed to study the effects of puerarin (Pue) in combination with BM-MSCs on cerebral ischemic injury.Methods: After middle cerebral artery occlusion (MCAO) models were prepared by suture-occluded method, rats were randomly allocated to the sham, MCAO, Pue (50 mg/kg), BM-MSCs (2×106), and BM-MSCs+Pue groups. The neurological function, infarct area, levels of inflammation-related factors, brain tissue damage, apoptosis, BrdU, Beclin1, and LC3 levels were then assessed.Results: Pue and BM-MSCs reduced the modified neurological severity score, cerebral infarction area, and serum inflammation-related factor levels for MCAO rats. Furthermore, Pue and BM-MSCs interventions ameliorated brain tissue damage, and repressed apoptosis of brain tissues in MCAO rats. Moreover, Pue or BM-MSCs enhanced BrdU expression, restrained LC3II/LC3I ratio and Beclin 1 expression in MCAO rats' brain tissues. Importantly, the combination of Pue and BM-MSCs exhibited more pronounced effects on aforementioned outcomes.Conclusion: The combination of Pue and BM-MSCs facilitated the recovery of neurological function in rats after cerebral ischemic damage, and the mechanisms may correlate with the repression of neuronal apoptosis, inflammation, and autophagy.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"370-380"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0