Brain injury最新文献_第4页

The interaction between neck pain and known determinates of delayed return to play among NCAA student-athletes: a CARE consortium study. 颈部疼痛与NCAA学生运动员延迟回归的已知决定因素之间的相互作用：一项CARE联盟研究。

IF 1.8 4区医学

Brain injury Pub Date : 2025-08-27 DOI: 10.1080/02699052.2025.2551163

Kelly M Cheever, Jeffery King, Jianmin Guan, Jordan Gliedit, Steven Broglio, Paul F Pasquina, Joseph B Hazzard, James R Clugston, Luis A Feigenbaum, Christopher M Miles, Thomas A Buckley, Holly J Benjamin, Christina Master, Anthony P Kontos, Nicholas Port, Kenneth Cameron, Jason P Mihalik

{"title":"The interaction between neck pain and known determinates of delayed return to play among NCAA student-athletes: a CARE consortium study.","authors":"Kelly M Cheever, Jeffery King, Jianmin Guan, Jordan Gliedit, Steven Broglio, Paul F Pasquina, Joseph B Hazzard, James R Clugston, Luis A Feigenbaum, Christopher M Miles, Thomas A Buckley, Holly J Benjamin, Christina Master, Anthony P Kontos, Nicholas Port, Kenneth Cameron, Jason P Mihalik","doi":"10.1080/02699052.2025.2551163","DOIUrl":"https://doi.org/10.1080/02699052.2025.2551163","url":null,"abstract":"Background: Acute neck pain following a concussion has been identified as a symptom associated with a delay in symptom resolution and persistent post-concussion symptoms (PPCS), but little is known about the relationship between the presence of acute neck pain and other known risk factors of delayed return to play (RTP) such as sex, sport contact level, and race.Methods: This study reports the findings of a secondary data analysis of a prospective cohort study sample from the Concussion Assessment, Research, and Education (CARE) Consortium. We examined the possible mediating effects of neck pain severity on known factors of delayed RTP (sex, sport contact level, and race) following a suspected concussion.Results: While neck pain was identified as significant predictor of delayed RTP (b = .046, S.E. = .021, Wald χ2(1) = 4.745, p = 0.029), no interaction effect was observed between neck pain and the explored mediating factors of sex, sport contact level, and race.Conclusions: These results suggest that independent of an individual's sex, sport contact level, and/or race, the presence of neck pain following a suspected concussion should be further evaluated and differentially diagnosed to rule out comorbid pathologies that may be contributing to PPCS following a suspected concussion.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-6"},"PeriodicalIF":1.8,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary embolism in patients with traumatic brain injury in the United States during 2016-2020. 2016-2020年美国外伤性脑损伤患者的肺栓塞

IF 1.8 4区医学

Brain injury Pub Date : 2025-08-27 DOI: 10.1080/02699052.2025.2549941

Carlos Garcia, Armin Karamian, Travis Kotzur, Rajesh Gunaji, Brooke Lajeunesse, Margaret Moran, Paola Martinez, Kevin Chen, Ali Seifi

{"title":"Pulmonary embolism in patients with traumatic brain injury in the United States during 2016-2020.","authors":"Carlos Garcia, Armin Karamian, Travis Kotzur, Rajesh Gunaji, Brooke Lajeunesse, Margaret Moran, Paola Martinez, Kevin Chen, Ali Seifi","doi":"10.1080/02699052.2025.2549941","DOIUrl":"https://doi.org/10.1080/02699052.2025.2549941","url":null,"abstract":"Objectives: This study aims to find the incidence of pulmonary embolism (PE) in traumatic brain injury (TBI) and the impact of comorbidities on the development of PE in the United States.Methods: This is a retrospective study of inpatient subjects from 2016 to 2020 in the United Stateswith TBI collected from the Healthcare Cost and Utilization Project (HCUP). Patients were evaluated for demographics, types of TBI, comorbidities, and complications. Regression statistical analyses were conducted to find the odds of developing PE after TBI.Results: 219,005 TBI cases were included, of which 1,367 developed PE (0.6%). The cohort was mostly white (71%), and males (60%), with a mean age of 61.75 y/o. The patients who developed PE were younger (60.36 vs. 61.76, p < 0.001), had longer hospital stays (18.6 vs. 6.8 days, p < 0.001), and had significantly higher mortality (14% vs. 8%, p < 0.001). In multivariate analysis, having lower DVT (OR 10.16 [9.07-11.39], p < 0.001), upper DVT (OR 2.78 [2.26-3.42], p < 0.001), pneumonia (OR 1.35 [1.21-1.51], p < 0.001), myocardial infarction (OR 1.28 [1.00-1.63], p = 0.049), and sepsis (OR 1.26 [1.08-1.48], p = 0.004), had the highest association with developing PE following TBI.Conclusions: Our data show that the incidence of PE in TBI patients is low; however, it is lethal with longer hospital stay. The risk of PE is higher in those with comorbidities such as paralysis, AIDS/HIV, metastatic cancer, and fluid/electrolyte disorders.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-10"},"PeriodicalIF":1.8,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IGF-1 as a biomarker for symptom severity in adolescents with traumatic brain injury. IGF-1作为创伤性脑损伤青少年症状严重程度的生物标志物

IF 1.8 4区医学

Brain injury Pub Date : 2025-08-26 DOI: 10.1080/02699052.2025.2552336

Varun Mishra, Kimberly Rosenthal, Emily Hillaker, Melissa Martinez, Jennifer Bath, William Ide, Joshua Stodghill, Tonja Locklear, Justin Weppner

{"title":"IGF-1 as a biomarker for symptom severity in adolescents with traumatic brain injury.","authors":"Varun Mishra, Kimberly Rosenthal, Emily Hillaker, Melissa Martinez, Jennifer Bath, William Ide, Joshua Stodghill, Tonja Locklear, Justin Weppner","doi":"10.1080/02699052.2025.2552336","DOIUrl":"https://doi.org/10.1080/02699052.2025.2552336","url":null,"abstract":"Objective: This study assessed the relationship between insulin-like growth factor 1 (IGF-1) level and symptom severity in adolescents with traumatic brain injury (TBI), focusing on correlation with post-injury symptom severity, depression, and anxiety.Design: This retrospective observational study included adolescents aged 13-17 years (n = 52) with mild TBI (mTBI, n = 30) or moderate/severe TBI (msTBI, n = 22), based on best Glasgow Coma Scale score recorded in the first 24 h post-injury. Participants were 3-12 months post-TBI with available IGF-1 values and complete Rivermead Post Concussion Symptoms Questionnaire (RPQ-13), Generalized Anxiety Disorder-7 (GAD-7), and Patient Health Questionnaire-9 (PHQ-9) responses. Outcome measures were correlated with IGF-1 z-scores with Kendall's Tau analysis.Results: RPQ-13 and GAD-7 scores were significantly higher in msTBI (p = 0.0472 and p = 0.0085, respectively). IGF-1 z-scores negatively correlated with RPQ-13 scores in mTBI (tau = -0.65, p < 0.0001) and msTBI (tau = -0.85, p < 0.0001), and with GAD-7 scores in mTBI (tau = -0.30, p = 0.0302) and msTBI (tau = -0.39, p = 0.0144). Only msTBI demonstrated a significant negative correlation between IGF-1 z-score and PHQ-9 scores (tau = -0.82, p < 0.0001).Conclusions: Adolescents with msTBI experienced greater post-injury symptom severity and anxiety than those with mTBI. Low IGF-1 levels correlated with greater post-injury symptom severity, anxiety, and depression (msTBI only), supporting IGF-1 as a potential biomarker in adolescent TBI.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-6"},"PeriodicalIF":1.8,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intensive exposure therapy for individuals with persistent concussion symptoms following concussion: a replicated single-case experimental design (SCED) study. 强化暴露疗法对脑震荡后持续性脑震荡症状患者的治疗：一项重复单例实验设计（SCED）研究

IF 1.8 4区医学

Brain injury Pub Date : 2025-08-13 DOI: 10.1080/02699052.2025.2544624

Skye King, Ieke Winkens, Joukje van der Naalt, Caroline M van Heugten, Marleen M Rijkeboer

{"title":"Intensive exposure therapy for individuals with persistent concussion symptoms following concussion: a replicated single-case experimental design (SCED) study.","authors":"Skye King, Ieke Winkens, Joukje van der Naalt, Caroline M van Heugten, Marleen M Rijkeboer","doi":"10.1080/02699052.2025.2544624","DOIUrl":"https://doi.org/10.1080/02699052.2025.2544624","url":null,"abstract":"Introduction: Persistent concussion symptoms (PCS) after mild traumatic brain injury (mTBI) interfere with daily functioning. The study aimed to replicate findings of our previous work showing the efficacy of an intensive exposure therapy for PCS.Method: A replication was conducted with four participants (age M = 25.5, time-since-injury M = 13.25), using a multiple-baseline multi-phase (A-B-C-D-E) single-case experimental design. A randomly assigned baseline (A) preceded the 4-week exposure intervention (B - exploration, C - active exposure, D - booster) conducted by psychologists, with a 4-week follow-up (E). The primary measures, including active avoidance, believability, satisfaction, and symptom experience, were assessed daily on visual analogue scales. Secondary measures of symptom severity, catastrophizing, activity avoidance, anxiety, depression, societal participation and therapeutic alliance were measured across four time points.Results: Significant effects were shown in visual and Tau-U analysis for all participants on all primary measures comparing baseline and intervention phases. For all primary measures, the pooled standardized mean difference (PSMD) was high. Clear improvements were seen on all secondary measures except anxiety.Conclusions: The findings of this study further confirmed the efficacy for this intensive exposure therapy for PCS, adding further evidence for exposure therapy in this patient population. Replication in other samples is needed.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-9"},"PeriodicalIF":1.8,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal trajectories of family functioning following pediatric traumatic brain injury. 儿童创伤性脑损伤后家庭功能的纵向轨迹。

IF 1.8 4区医学

Brain injury Pub Date : 2025-08-10 DOI: 10.1080/02699052.2025.2545989

Felicity Murphy, Cathy Catroppa, Elle Morrison, Edith N Botchway-Commey, Stephen Hearps, Daniel A P Geraghty, Nikita Tuli Sood, Vicki Anderson

{"title":"Longitudinal trajectories of family functioning following pediatric traumatic brain injury.","authors":"Felicity Murphy, Cathy Catroppa, Elle Morrison, Edith N Botchway-Commey, Stephen Hearps, Daniel A P Geraghty, Nikita Tuli Sood, Vicki Anderson","doi":"10.1080/02699052.2025.2545989","DOIUrl":"https://doi.org/10.1080/02699052.2025.2545989","url":null,"abstract":"Objective: To investigate the presence of specific family functioning trajectories in the 7-10 years after pediatric traumatic brain injury (TBI) and explore predictors associated with these trajectories.Methods: One hundred and thirty-seven families of children aged 1-12 years who experienced traumatic brain injury were prospectively recruited from a single site, statewide tertiary pediatric hospital. Assessments of family functioning were undertaken using the Intimacy, Conflict and Parenting Style: Family Functioning Scale at preinjury, 6-months, 12-months, 30-months, and 7-10 years. Group-based trajectory modeling was used to identify latent trajectories of functioning. Associations with child, family, and injury characteristics were explored.Results: We identified four distinct family intimacy profiles, four conflict profiles, and three parenting style profiles. Profiles were characterized by their level of functioning, which remained mostly stable from pre-injury levels across the 7-10 years post-injury. Trajectory membership was not reliably related to characteristics of the child, family, or injury.Conclusions: These findings suggest that, while families operate at different levels of intimacy, conflict, and parenting flexibility, these do not change after a child's TBI. Given the established role of family functioning in shaping recovery outcomes, assessments of pre-injury family functioning may enable identification of families with children at risk for poorer outcomes post-TBI.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-10"},"PeriodicalIF":1.8,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of knowledge and attitude on inappropriate post-concussion behaviors in competitive cyclists. 知识和态度对竞技自行车运动员脑震荡后不当行为的影响。

IF 1.8 4区医学

Brain injury Pub Date : 2025-08-03 DOI: 10.1080/02699052.2025.2539891

Yudai Sasaki, Junji Inoue, Toshihiro Maemichi, Haruo Nakayama, Tsukasa Kumai

{"title":"Impact of knowledge and attitude on inappropriate post-concussion behaviors in competitive cyclists.","authors":"Yudai Sasaki, Junji Inoue, Toshihiro Maemichi, Haruo Nakayama, Tsukasa Kumai","doi":"10.1080/02699052.2025.2539891","DOIUrl":"https://doi.org/10.1080/02699052.2025.2539891","url":null,"abstract":"Objectives: To measure epidemiological data on concussions and examine the association between knowledge and attitudes about concussions and inappropriate post-injury behavior.Design: Descriptive, cross-sectional study.Setting: Online survey.Participants: A total of 365 competitive cyclists in Japan.Main outcome measures: Survey items included participant information, the experience of concussion-like symptoms, concussion knowledge index (CKI) score, concussion attitude index (CAI) score, and inappropriate behavior post-concussion injury.Results: The prevalence of concussion-like symptoms among all competitive cyclists was 45.8%. CKI and CAI scores for all participants were 21.7 ± 3.4 and 10.5 ± 3.4, respectively. No significant differences were identified in CKI and CAI scores based on concussion-like symptom experience. After adjusting for covariates, we found that the risk of 'returning to training without rest after injury' decreased by 20% for each 1-point increase in CKI score. In contrast, the risk of 'returning to training with symptoms remaining' decreased by 13% for each 1-point increase in CAI.Conclusions: An association was found between concussion knowledge and return to competition without a period of rest post-injury, as well as between attitude toward concussion and return to competition with symptoms. Therefore, these findings can contribute to concussion education among cyclists.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-7"},"PeriodicalIF":1.8,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 1.8 4区医学

Brain injury Pub Date : 2025-08-01 Epub Date: 2025-04-27 DOI: 10.1080/02699052.2025.2497702

引用次数: 0

Involvement of physiological reactivity and interoception in emotional experience after a traumatic brain injury. 创伤性脑损伤后情绪体验中生理反应和内感受的参与。

IF 1.5 4区医学

Brain injury Pub Date : 2025-08-01 Epub Date: 2025-04-13 DOI: 10.1080/02699052.2025.2490977

Alice Bodart, Sandra Invernizzi, Laurent Lefebvre, Mandy Rossignol

{"title":"Involvement of physiological reactivity and interoception in emotional experience after a traumatic brain injury.","authors":"Alice Bodart, Sandra Invernizzi, Laurent Lefebvre, Mandy Rossignol","doi":"10.1080/02699052.2025.2490977","DOIUrl":"10.1080/02699052.2025.2490977","url":null,"abstract":"Objective: Emotional experience is based, among other factors, on physiological reactivity (PR) and the awareness of this reactivity corresponding to interoception. After a traumatic brain injury (TBI), patients exhibit reduced PR and interoception, raising questions about the integrity of their emotional experience.Method: To examine this issue, 26 men with moderate to severe TBI (age: 37 ± 11) and 26 healthy male controls (age: 35 ± 14) watched emotional films (amusement, tenderness, anger, disgust). PR was measured via electrodermal activity (EDA) and heart rate variability (HRV). After each film, an emotional evaluation was completed using the Differential Emotional Scale (DES). Interoception was measured through a heartbeat counting (HBC) task and the Multidimensional Assessment of Interoceptive Awareness (MAIA) questionnaire.Results: Compared to controls, TBI participants scored lower on the MAIA Emotional Awareness and Noticing subscales, and exhibited lower EDA and HRV during the anger and tenderness films. However, emotional evaluations and HBC task scores were similar between groups. Positive correlations were found between emotional evaluation and the MAIA scale.Conclusion: These results suggest a dissociation between emotional experience and PR after TBI and decreased interoceptive sensitivity. Since interoception links PR and emotional experience, exploring the impact of reduced interoception on this dissociation could improve our understanding of post-TBI emotional functioning.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"847-858"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"There's a lot that's different, but it's still me": exploring podcast narratives of emotional adjustment after encephalitis. “有很多不同，但它仍然是我”：探索脑炎后情绪调整的播客叙述。

IF 1.5 4区医学

Brain injury Pub Date : 2025-08-01 Epub Date: 2025-04-09 DOI: 10.1080/02699052.2025.2487612

Emma O'Connor, Antigoni Kasinopoulou, Danny O'Donoghue, Jane Sekibo, Eeshvari Morey, Jack Versace, Nicholas Cummins, Thomas Pollak, Ava Easton, Sara Simblett

{"title":"\"There's a lot that's different, but it's still me\": exploring podcast narratives of emotional adjustment after encephalitis.","authors":"Emma O'Connor, Antigoni Kasinopoulou, Danny O'Donoghue, Jane Sekibo, Eeshvari Morey, Jack Versace, Nicholas Cummins, Thomas Pollak, Ava Easton, Sara Simblett","doi":"10.1080/02699052.2025.2487612","DOIUrl":"10.1080/02699052.2025.2487612","url":null,"abstract":"Background: Encephalitis can lead to acquired brain injury (ABI) with neuropsychiatric consequences. Emotional adjustment is important for ensuring positive, long-term outcomes. The transdiagnostic cognitive behavioral therapy (T-CBT) model offers a way of understanding adjustment post-encephalitis but has not yet been tested. We qualitatively assessed whether the T-CBT model accurately captured recovery experiences post-encephalitis and whether experiences differed between infectious and autoimmune encephalitis.Methods: A directed content analysis was used to inductively code spoken experiences of encephalitis survivors (n = 15), as told through public podcasts, and apply a deductive coding framework built from the T-CBT model. A second inductive content analysis was used to explore the podcast interview questions.Results: The T-CBT model broadly captured the experiences of emotional adjustment post-encephalitis. Threat to self-identity and responses to these threats, amongst other contextual factors, were important. An additional major category emerged to capture the impact of encephalitis on close others. No discernible pattern was found between survivors of infectious (n = 6) and autoimmune (n = 6) encephalitis.Conclusions: The T-CBT model with additional systemic factors can help to understand emotional adjustment after encephalitis and provides a rationale for psychological therapy as a treatment during the recovery phase.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"820-833"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-cerebral ischemia energy crisis: the role of glucose metabolism in the energetic crisis. 脑缺血后能量危机：葡萄糖代谢在能量危机中的作用。

IF 1.8 4区医学

Brain injury Pub Date : 2025-08-01 Epub Date: 2025-04-16 DOI: 10.1080/02699052.2025.2492751

Jia-Ting Li, Dian Ou, Yi-Ming Shi, Le Bao, Yan-Ling Li, Ting-Ting Xiong, Yang Bai, Huang Ding

{"title":"Post-cerebral ischemia energy crisis: the role of glucose metabolism in the energetic crisis.","authors":"Jia-Ting Li, Dian Ou, Yi-Ming Shi, Le Bao, Yan-Ling Li, Ting-Ting Xiong, Yang Bai, Huang Ding","doi":"10.1080/02699052.2025.2492751","DOIUrl":"10.1080/02699052.2025.2492751","url":null,"abstract":"Background: Cells universally employ an efficiency-driven metabolic switch mechanism during nutritional changes, growth, and differentiation, transitioning from oxidative phosphorylation (OXPHOS) to glycolysis to ensure survival under hypoxic conditions or high energy demands. In cerebral ischemia, inadequate blood supply causes oxygen and energy deprivation, prompting brain cells to initiate glycolytic reprogramming to meet urgent energy needs. While this adaptation is a temporary solution, it may lead to lactic acidosis, aggravated inflammation, and increased free radical production. Prolonged reperfusion with sustained glycolysis can exacerbate brain cell damage, potentially causing irreversible harm.Objectives: This review systematically examines the dynamic changes in glucose metabolic transport mechanisms and the roles of immediate, early, intermediate, and late responder cells, along with their regulatory factors, in glycolytic reprogramming.Methods: Using a temporal analysis framework based on the body's natural response sequence to pathological events, we elucidate how cells at different stages collaborate to address glucose metabolism reprogramming under pathological conditions.Conclusions: Reversing glucose metabolism reprogramming and inhibiting glycolysis may improve the pathological processes of ischemic stroke, offering potential therapeutic benefits.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"893-903"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0