Pulmonary embolism in patients with traumatic brain injury in the United States during 2016-2020.

IF 1.8 4区医学 Q4 NEUROSCIENCES

Brain injury Pub Date : 2025-08-27 DOI:10.1080/02699052.2025.2549941

Carlos Garcia, Armin Karamian, Travis Kotzur, Rajesh Gunaji, Brooke Lajeunesse, Margaret Moran, Paola Martinez, Kevin Chen, Ali Seifi

{"title":"Pulmonary embolism in patients with traumatic brain injury in the United States during 2016-2020.","authors":"Carlos Garcia, Armin Karamian, Travis Kotzur, Rajesh Gunaji, Brooke Lajeunesse, Margaret Moran, Paola Martinez, Kevin Chen, Ali Seifi","doi":"10.1080/02699052.2025.2549941","DOIUrl":null,"url":null,"abstract":"Objectives: This study aims to find the incidence of pulmonary embolism (PE) in traumatic brain injury (TBI) and the impact of comorbidities on the development of PE in the United States.Methods: This is a retrospective study of inpatient subjects from 2016 to 2020 in the United Stateswith TBI collected from the Healthcare Cost and Utilization Project (HCUP). Patients were evaluated for demographics, types of TBI, comorbidities, and complications. Regression statistical analyses were conducted to find the odds of developing PE after TBI.Results: 219,005 TBI cases were included, of which 1,367 developed PE (0.6%). The cohort was mostly white (71%), and males (60%), with a mean age of 61.75 y/o. The patients who developed PE were younger (60.36 vs. 61.76, p < 0.001), had longer hospital stays (18.6 vs. 6.8 days, p < 0.001), and had significantly higher mortality (14% vs. 8%, p < 0.001). In multivariate analysis, having lower DVT (OR 10.16 [9.07-11.39], p < 0.001), upper DVT (OR 2.78 [2.26-3.42], p < 0.001), pneumonia (OR 1.35 [1.21-1.51], p < 0.001), myocardial infarction (OR 1.28 [1.00-1.63], p = 0.049), and sepsis (OR 1.26 [1.08-1.48], p = 0.004), had the highest association with developing PE following TBI.Conclusions: Our data show that the incidence of PE in TBI patients is low; however, it is lethal with longer hospital stay. The risk of PE is higher in those with comorbidities such as paralysis, AIDS/HIV, metastatic cancer, and fluid/electrolyte disorders.","PeriodicalId":9082,"journal":{"name":"Brain injury","volume":" ","pages":"1-10"},"PeriodicalIF":1.8000,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain injury","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/02699052.2025.2549941","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: This study aims to find the incidence of pulmonary embolism (PE) in traumatic brain injury (TBI) and the impact of comorbidities on the development of PE in the United States.

Methods: This is a retrospective study of inpatient subjects from 2016 to 2020 in the United Stateswith TBI collected from the Healthcare Cost and Utilization Project (HCUP). Patients were evaluated for demographics, types of TBI, comorbidities, and complications. Regression statistical analyses were conducted to find the odds of developing PE after TBI.

Results: 219,005 TBI cases were included, of which 1,367 developed PE (0.6%). The cohort was mostly white (71%), and males (60%), with a mean age of 61.75 y/o. The patients who developed PE were younger (60.36 vs. 61.76, p < 0.001), had longer hospital stays (18.6 vs. 6.8 days, p < 0.001), and had significantly higher mortality (14% vs. 8%, p < 0.001). In multivariate analysis, having lower DVT (OR 10.16 [9.07-11.39], p < 0.001), upper DVT (OR 2.78 [2.26-3.42], p < 0.001), pneumonia (OR 1.35 [1.21-1.51], p < 0.001), myocardial infarction (OR 1.28 [1.00-1.63], p = 0.049), and sepsis (OR 1.26 [1.08-1.48], p = 0.004), had the highest association with developing PE following TBI.

Conclusions: Our data show that the incidence of PE in TBI patients is low; however, it is lethal with longer hospital stay. The risk of PE is higher in those with comorbidities such as paralysis, AIDS/HIV, metastatic cancer, and fluid/electrolyte disorders.

查看原文本刊更多论文

2016-2020年美国外伤性脑损伤患者的肺栓塞

目的：本研究旨在了解美国创伤性脑损伤（TBI）肺栓塞（PE）的发生率及合并症对PE发展的影响。方法：这是一项回顾性研究，从医疗成本和利用项目（HCUP）中收集了2016年至2020年在美国住院的TBI患者。对患者进行人口统计学、TBI类型、合并症和并发症的评估。通过回归统计分析发现脑外伤后发生PE的几率。结果：共纳入TBI病例219,005例，其中PE 1,367例（0.6%）。该队列以白人（71%）和男性（60%）为主，平均年龄为61.75岁。发生PE的患者较年轻（60.36 vs. 61.76, p p p p p p p = 0.049），脓毒症（OR 1.26 [1.08-1.48], p = 0.004）与TBI后发生PE的相关性最高。结论：我们的数据显示，TBI患者PE的发生率较低；然而，随着住院时间的延长，它是致命的。合并瘫痪、艾滋病/艾滋病、转移性癌症和体液/电解质紊乱等合并症的患者发生PE的风险更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Brain injury 医学-康复医学

CiteScore

3.50

自引率

5.30%

发文量

148

审稿时长

12 months

期刊介绍： Brain Injury publishes critical information relating to research and clinical practice, adult and pediatric populations. The journal covers a full range of relevant topics relating to clinical, translational, and basic science research. Manuscripts address emergency and acute medical care, acute and post-acute rehabilitation, family and vocational issues, and long-term supports. Coverage includes assessment and interventions for functional, communication, neurological and psychological disorders.