BMC Oral Health最新文献

{"title":"Multimorbidity patterns of dental caries and obesity/overweight among adults: a systematic review and meta-analysis.","authors":"Su-Tong Yu, Jing-Yi Hua, Yu-Han Zeng, Shi-Yu Yu, Zi-Yu Zhang, Wan-Shu Xiao, Dan-Lin Li","doi":"10.1186/s12903-025-06371-x","DOIUrl":"https://doi.org/10.1186/s12903-025-06371-x","url":null,"abstract":"<p><strong>Background: </strong>Obesity and dental caries may share common dietary and metabolic risk factors, but their association in adults remains unclear. This systematic review and meta-analysis aim to evaluate the impact of obesity/overweight on dental caries in adults.</p><p><strong>Methods: </strong>PubMed, Web of Science, Cochrane Library, and Wiley databases were searched for relevant studies published between January 2000 and January 2025. Observational studies assessing the association between obesity/overweight and dental caries were included. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using random-effects models.</p><p><strong>Results: </strong>Eighteen cross-sectional studies with 270,408 participants were included. The meta-analysis found no significant association between obesity/overweight and dental caries risk (OR = 1.06, 95% CI = 0.98-1.14, P < 0.001). Subgroup analyses showed no significant differences based on BMI classification or geographical region. However, studies that did not adjust for confounders reported a positive association (OR = 1.17, 95% CI = 1.04-1.29, P = 0.036), which disappeared after adjusting for confounders (OR = 1.00, 95% CI = 0.89-1.12, P < 0.001).</p><p><strong>Conclusions: </strong>Obesity/overweight was not significantly associated with dental caries in adults, suggesting that previously observed relationships may be influenced by shared risk factors such as dietary habits, age and socioeconomic status. Future studies should pay attention to potential confounders and adopting prospective cohort designs or Mendelian randomization approaches may help explore causual relationshhips.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1037"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of two different artificial intelligence models in dental implant planning among four different implant planning software: a comparative study.","authors":"Pathompong Roongruangsilp, Walita Narkbuakaew, Pathawee Khongkhunthian","doi":"10.1186/s12903-025-06336-0","DOIUrl":"https://doi.org/10.1186/s12903-025-06336-0","url":null,"abstract":"<p><strong>Background: </strong>The integration of artificial intelligence (AI) in dental implant planning has emerged as a transformative approach to enhance diagnostic accuracy and efficiency. This study aimed to evaluate the performance of two object detection models, Faster R-CNN and YOLOv7 in analyzing cross-sectional and panoramic images derived from DICOM files processed by four distinct dental imaging software platforms.</p><p><strong>Methods: </strong>The dataset consisted of 332 implant position images derived from DICOM files of 184 CBCT scans. Three hundred images were processed using DentiPlan Pro 3.7 software (NECTEC, NSTDA, Thailand) for the development of Faster R-CNN and YOLOv7 models for dental implant planning. For model testing, 32 additional implant position images, which were not included in the training set, were processed using four different software programs: DentiPlan Pro 3.7, DentiPlan Pro Plus 5.0 (DTP; NECTEC, NSTDA, Thailand), Implastation (ProDigiDent USA, USA), and Romexis 6.0 (Planmeca, Finland). The performance of the models was evaluated using detection rate, accuracy, precision, recall, F1 score, and the Jaccard Index (JI).</p><p><strong>Results: </strong>Faster R-CNN achieved superior accuracy across imaging modalities, while YOLOv7 demonstrated higher detection rates, albeit with lower precision. The impact of image rendering algorithms on model performance underscores the need for standardized preprocessing pipelines. Although Faster R-CNN demonstrated relatively higher performance metrics, statistical analysis revealed no significant differences between the models (p-value > 0.05).</p><p><strong>Conclusions: </strong>This study emphasizes the potential of AI-driven solutions in dental implant planning and advocates the need for further research in this area. The absence of statistically significant differences between Faster R-CNN and YOLOv7 suggests that both models can be effectively utilized, depending on the specific requirements for accuracy or detection. Furthermore, the variations in imaging rendering algorithms across different software platforms significantly influenced the model outcomes. AI models for DICOM analysis should rely on standardized image rendering to ensure consistent performance.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"984"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brown tumors of both jaws as the initial manifestation of a case of parathyroid carcinoma: a case with a 2-year follow-up.","authors":"Najmeh Movahhedian, Roya Khorrami, Farhad Ghorbani, Razieh Zare","doi":"10.1186/s12903-025-06370-y","DOIUrl":"https://doi.org/10.1186/s12903-025-06370-y","url":null,"abstract":"<p><strong>Background: </strong>Brown tumors are non-neoplastic giant cell lesions resulting from imbalanced bone metabolism associated with hyperparathyroidism. Although these tumors are infrequently found in the jaw bones, their presence can mimic other bony lesions, making differential diagnosis essential for effective treatment planning.</p><p><strong>Case presentation: </strong>Here, we present a rare case of simultaneous involvement of both jaws by brown tumors in a 37-year-old woman. A comprehensive diagnostic approach including cone beam computed tomographic examination of the jaws, blood biochemistry, scintigraphy (technetium 99 m sestamibi), and biopsy facilitated the identification of underlying parathyroid carcinoma. Notably, the patient experienced spontaneous healing of the extensive brown tumors following endocrine treatment, underscoring the potential for recovery in such cases.</p><p><strong>Conclusion: </strong>This case highlights the essential collaboration between dental and medical professionals in diagnosing complex systemic diseases with oral manifestations, underscoring the dentist's critical role in early detection and improved patient outcomes.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"979"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of two different digital construction techniques of mandibular implant-assisted overdentures on peri-implant bone loss and posterior ridge resorption: a 3-year prospective randomized clinical trial.","authors":"Nermeen El Sayed El Khamisy, Radwa M K Emera, Thuraya Maher Elmanci, Marwa Ahmed Aboelez","doi":"10.1186/s12903-025-06425-0","DOIUrl":"https://doi.org/10.1186/s12903-025-06425-0","url":null,"abstract":"<p><strong>Objectives: </strong>Traditional complete denture (CD) design and fabrication techniques need several clinical and laboratory steps. To improve the qualities of denture base material and get rid of all the problems that come with the conventional fabrication process, novel production methods were approved. In the field of denture manufacture, new materials and computer-aided technology have been explored as potential solutions. So, this study aimed to investigate the effect of two different digital construction techniques of implant-assisted overdentures on peri-implant and posterior mandibular bone resorptions by CBCT.</p><p><strong>Materials and methods: </strong>Twenty patients who received mandibular overdenture constructed by different construction techniques were classified equally and randomly into two groups (n = 10 per group): Group M: received milled mandibular overdenture opposed by maxillary complete denture. Group P: received 3D-printed mandibular overdenture opposed by maxillary complete denture. Peri-implant bone loss and posterior ridge resorption were assessed at baseline (T0), at 1 year(T1), and 3 years(T3) by superimposition of pre and post-treatment CBCT.The Shapiro-Wilk test was used to access data that was not normally distributed. Two distinct groups were compared using the Mann-Whitney test. The Wilcoxon signed-rank test was used to compare paired groups.</p><p><strong>Results: </strong>Regarding vertical bone loss(VBL), Group P recorded higher VBL in comparison to Group M, where the mean was 0.57 ± 0.13, and 0.52 ± 0.12respectively, at T1 and 0.66 ± 0.11, 0.60 ± 0.12 at T3. There was a statistically significant difference at different times of evaluation within the groups where (P < 0.001). Regarding posterior ridge resorption(PRR), Group P recorded higher PRR in comparison to Group M, where the mean was 381 ± 18.5, 333 ± 17.2 respectively at T1and 533 ± 24.9, 478.5 ± 12.3 at T3. There was a statistically significant difference at different times of evaluation within the groups where (P = 0.005).</p><p><strong>Conclusion: </strong>Regarding the preservation of peri-implant alveolar bone and posterior ridge bone, milled implant-assisted complete overdentures may have more favorable clinical outcomes compared to 3D printed implant overdentures in the digitally constructed mandibular overdenture bases retained by two implants.</p><p><strong>Clinical relevance: </strong>Both milled and 3D printed implant overdenture impression techniques can be used for the construction of CAD/CAM-implant retained overdenture base. However, in regarding the peri-implant alveolar bone and posterior ridge bone resorption, milled implant-assisted complete overdentures may have more favorable clinical outcomes compared to 3D printed implant overdentures retained by two implants.</p><p><strong>Clinical trial registry number: </strong>(No.-NCT06720389) (03/12/2024).</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1040"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of in-office bleaching agents on the optical properties of universal resin composites: an in vitro analysis.","authors":"Esra Özyurt, Merve Nezir, Hanife Altınışık, Mediha Büyükgöze Dindar","doi":"10.1186/s12903-025-06417-0","DOIUrl":"https://doi.org/10.1186/s12903-025-06417-0","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to evaluate the surface color stability, transluceny and gloss changes of seven different universal resin composites after bleaching treatment protocol.</p><p><strong>Methods: </strong>Fifty-six disc-shaped specimens were prepared, with eight specimens each of the universal resin composites Filtek Z250 (F), Filtek Universal (FU), Harmonize (H), Vittra Unique (VU), Omnichroma (O), Essentia Universal (EU), Charisma Diamond One (CDO). Prepared specimens were divided into two for color change, translucency, gloss (n = 8). Initial color and gloss measurements and translucency calculations were made on the prepared samples. After measurements, in-office bleaching gel was applied to the specimen surfaces three times, and each application time was 15 min. After the bleaching protocol, the measurements were repeated, and the values were statistically analyzed using the one-way ANOVA, Tukey HSD test, Kruskal-Wallis test, Dunn's test, Paired samples t-test (p < 0.05).</p><p><strong>Results: </strong>Vittra Unique group had statistically significantly higher ΔE values than the FU, H and EU groups (p < 0.05). CDO had significantly higher ΔE than the H group (p < 0.05). O had higher TP values than all other groups for T0 and T1 (p < 0.05). A significant decrease in gloss values ​​was observed after bleaching in all material groups compared to the initial.</p><p><strong>Conclusions: </strong>The organic content of resin composites is an important factor in color stability, with higher molecular weight resins may being less affected by bleaching agents.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1016"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of restorative treatment for symptomatic deep dentin caries on anxiety: the role of personality traits.","authors":"Fikri Öcal, Yasemin Demirtaş Öcal","doi":"10.1186/s12903-025-06413-4","DOIUrl":"https://doi.org/10.1186/s12903-025-06413-4","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to examine the short-term effects of restorative treatment for deep dentin caries on patients' pain, state-trait anxiety, and mood, and to explore how these outcomes are associated with personality traits.</p><p><strong>Methods: </strong>This prospective clinical study included 67 participants (45 female, 22 male; mean age = 30.1 ± 13.2 years) presenting with symptomatic deep dentin caries. State and trait anxiety levels were assessed using the State-Trait Anxiety Inventory (STAI-S, STAI-T), and personality traits were evaluated using the Big Five Inventory (BFI-44). Pain and mood were measured using Visual Analog Scales (VAS-DP, VAS-M) before treatment and at three weeks post-treatment. All participants received indirect pulp capping and/or direct composite restorations. Independent-samples t-tests, Paired-samples t-tests, correlation and simple linear regression analyses were used to assess changes and relationships among variables.</p><p><strong>Results: </strong>A statistically significant decrease was found in state anxiety (STAI-S), pain (VAS-DP), and mood disturbance (VAS-M) scores post-treatment (p < 0.05). Trait anxiety (STAI-T) did not change significantly. Individuals with high neuroticism displayed higher pre-treatment anxiety and pain levels, but also exhibited the greatest post-treatment improvement in mood and anxiety. Regression analyses indicated that neuroticism significantly predicted both state and trait anxiety (R² = 0.139 and R² = 0.255, respectively), while pre-treatment anxiety explained 12.7% of the variance in post-treatment state anxiety.</p><p><strong>Conclusions: </strong>Restorative treatment of deep dentin caries significantly reduces patients' state anxiety, pain, and mood impairment, with the most marked improvements observed in individuals with neurotic personality traits.</p><p><strong>Clinical significance: </strong>Restorative treatment for deep dentin caries not only reduces pain but also alleviates anxiety and improves mood. Considering personality traits, especially neuroticism, may enhance patient comfort and treatment satisfaction.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1007"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthodontic treatment of adult occlusal traumatic periodontitis using a twin block appliance: a case report.","authors":"Chenzhi Li, Xiao Yuan, DaPeng Ren","doi":"10.1186/s12903-025-06461-w","DOIUrl":"https://doi.org/10.1186/s12903-025-06461-w","url":null,"abstract":"<p><p>Malocclusion may lead to the development of occlusal trauma, which can exacerbate periodontal disease. Here, we present a skeletal Class II adult patient with occlusal traumatic periodontitis of upper incisors, who was treated with a two-phased orthodontic treatment. In the first phase, a Twin Block appliance (TBA) was used to increase the vertical dimension of the posterior teeth, to eliminate the anterior occlusal trauma. In addition, TBA also improved mandibular retrusion by forwarding the mandible. In the second phase of fixed orthodontics, occlusion was fine-tuned with infrazygomatic crest (IZC) miniscrews and Class II intermaxillary elastics. At the end of treatment, anterior occlusal trauma was eliminated, periodontal conditions of upper incisors were improved, a stable occlusion and a harmonious profile were obtained. The successful two-phased orthodontic treatment showed that the TBA can effectively eliminate anterior occlusal trauma through restoration of posterior vertical dimension, and can improve mandibular retrusion by forwarding mandible and reconstructing stable occlusion in adult patient.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1044"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet-rich fibrin versus acellular dermal matrix for vertical soft tissue augmentation simultaneously with dental implantation: a 3-month randomized pilot clinical trial.","authors":"Farid Shiezadeh, Amir Moeintaghavi, Zahra Moslehitabar, Moein Khojaste","doi":"10.1186/s12903-025-06394-4","DOIUrl":"https://doi.org/10.1186/s12903-025-06394-4","url":null,"abstract":"<p><strong>Background: </strong>Vertical soft tissue thickness is critical for peri-implant health and aesthetics. Platelet-rich fibrin (PRF) and acellular dermal matrix (ADM) are increasingly used for soft tissue augmentation during dental implantation, but direct comparisons of their efficacy are limited. This study aimed to compare the efficacy of PRF and ADM for vertical soft tissue augmentation, simultaneously with dental implantation.</p><p><strong>Methods: </strong>This pilot randomized controlled clinical trial included 20 patients with thin soft tissue phenotypes (≤ 2 mm) in the posterior mandible. Patients were randomly assigned to the PRF (n = 10) or ADM (n = 10) groups. The primary outcome was gingival thickness measured at baseline and three months postoperatively via a #15 endodontic file and a digital caliper. The Shapiro-Wilk test was used to assess data normality. Data were analyzed via independent and paired t-tests for normally distributed data and Mann-Whitney and Wilcoxon tests for non-normally distributed data. Chi-square tests and Fisher's exact tests used to compare sex distribution between groups. Between-group comparisons at baseline and three months were performed, with significance set at P < 0.05.</p><p><strong>Results: </strong>The baseline gingival thickness did not differ significantly between the groups (P = 0.19). At three months, gingival thickness significantly increased in both the PRF (from 1.66 ± 0.23 mm to 3.30 ± 0.75 mm) and ADM (from 1.52 ± 0.22 mm to 2.58 ± 0.47 mm) groups (P < 0.001 for both). Although the gingival thickness at three months was significantly greater in the PRF group (p = 0.02), the mean soft tissue gain was not significantly different between the groups (P = 0.081).</p><p><strong>Conclusions: </strong>Both PRF and ADM significantly increased gingival thickness three months post-surgery, with PRF resulting in greater overall thickness. These preliminary findings support using PRF and ADM as effective options for vertical soft tissue augmentation during dental implantation. However, given the pilot nature of this study, further research with larger sample sizes and longer follow-up periods is needed to validate these results.</p><p><strong>Trial registration: </strong>This project was registered in the Iranian Registry of Clinical Trials under the ID (IRCT20200914048713N1) and registration date 30/11/2021.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1060"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between periodontitis and blood lipid levels: a cross-sectional study.","authors":"Feiya Zhao, Wei Hu, Yunhong Wu, Yude Ding, Fan Yang","doi":"10.1186/s12903-025-06341-3","DOIUrl":"https://doi.org/10.1186/s12903-025-06341-3","url":null,"abstract":"<p><strong>Background: </strong>Dyslipidemia has been implicated as a risk factor for periodontitis; however, the underlying mechanisms remain poorly understood. This study aims to investigate the correlation between blood lipid levels and periodontitis and to explore the cellular and molecular mechanisms linking dyslipidemia to periodontal disease.</p><p><strong>Methods: </strong>Participants with complete data on serum lipid levels and periodontal examinations were selected from the 2009-2014 National Health and Nutrition Examination Survey (NHANES). Subgroup and logistic regression analyses were performed to assess the associations between periodontal status and lipid profiles, including triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and remnant cholesterol (RC). Single-cell Ribonucleic Acid (RNA) sequencing (scRNA-seq) statistical analysis, cellular metabolic pathway analysis, and CellChat were employed to examine cellular variations and intercellular communication in periodontal tissues with and without periodontitis.</p><p><strong>Results: </strong>A total of 5,342 participants were included in the analysis. Subgroup analyses revealed significant positive associations between elevated levels of TG, TC, and LDL-C and the prevalence of severe periodontitis. Participants in the high TC group had a 55% higher risk of severe periodontitis compared to those in the normal TC group (OR = 1.55, 95% CI: 1.17-2.05). Similarly, the risk of severe periodontitis increased by 50% in the high LDL-C group (OR = 1.50, 95% CI: 1.09-2.06) and by 35% in the high TG group (OR = 1.35, 95% CI: 1.02-1.79). scRNA-seq analysis revealed enhanced lipid metabolism in immune cells, particularly mast cells, within the periodontitis group. These mast cells were found to modulate fibroblast activity through inflammatory signaling pathways such as Interleukin 7 (IL7), Interleukin 15 (IL15).</p><p><strong>Conclusions: </strong>Elevated blood lipid levels are associated with an increased risk of severe periodontitis, potentially mediated by enhanced lipid metabolism in immune cells, particularly mast cells, and their interactions with fibroblasts via inflammatory signaling pathway. These findings suggest the importance of monitoring lipid levels in periodontitis patients with dyslipidemia and highlight potential therapeutic targets for managing periodontal disease in this population.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1055"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment outcomes of pulpotomy in primary molars utilizing 2.25% sodium hypochlorite gel: a randomized controlled trial.","authors":"Mawia Karkoutly, Amirah Alnour, Amjad Abu Hasna, Ok Hyung Nam, Saleh Al Kurdi, Nada Bshara","doi":"10.1186/s12903-025-06438-9","DOIUrl":"https://doi.org/10.1186/s12903-025-06438-9","url":null,"abstract":"<p><strong>Background: </strong>Sodium hypochlorite (NaOCl) gel can be a potential substitute in daily pediatric dentistry practice. Given its high antimicrobial efficacy, NaOCl gel is expected to induce healing and improve pulpotomy treatment outcomes. This study aimed to perform a histological, clinical, and radiographical evaluation of pulpotomy in human primary molars utilizing 2.25% (NaOCl) gel as a medicament, followed by white mineral trioxide aggregate (WMTA) as a base material.</p><p><strong>Materials and methods: </strong>A randomized, second-blinded, split-mouth clinical trial was conducted in cooperative patients aged 8-10 years with 48 carious first primary molars, which were treated by: (I) NaOCl gel group: following hemostasis, teeth were pulpotomized utilizing 2.25% NaOCl gel, and then WMTA paste was applied as a dressing material, and (II) control group: following hemostasis, WMTA paste was applied as a dressing material. Later, each group was sub-divided into three sub-groups (n = 8) according to the time planned for serial extraction: (I) 7 days, (II) 30 days, and (III) 90 days for histological evaluation. In addition, 40 s primary molars in cooperative patients aged 5-10 years indicated for pulpotomy were randomly allocated into two groups for clinical and radiographical evaluation at 3, 6, and 12 months follow-up. Data were analyzed by applying the chi-square test (p < 0.05).</p><p><strong>Results: </strong>NaOCl gel improved odontoblastic integrity and dentin bridge formation (p < 0.001) without increasing pulp necrosis or calcifications. The NaOCl gel group showed a 90% clinical and radiographical success rate at 3, 6, and 12 months of follow-up. In the control group, the clinical success rate was 85% after 3, 6, and 12 months, whereas the radiographical success rate was 100% at 3 months and decreased to 85% after 6 and 12 months.</p><p><strong>Conclusions: </strong>Utilizing 2.25% NaOCl gel as a medicament in human primary molars pulpotomy improved the treatment outcomes of the WMTA.</p><p><strong>Trial registration: </strong>ISRCTN registry, ISRCTN15908457, registered 22 July 2024.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1052"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}