BMC Oral Health最新文献

{"title":"Oral health-related quality of life in patients with type II diabetes mellitus: a systematic review and meta-analysis.","authors":"Joanna Slowik, Lukasz Kaczynski, Marcin Kaczor, Marcin Wnuk","doi":"10.1186/s12903-025-05882-x","DOIUrl":"10.1186/s12903-025-05882-x","url":null,"abstract":"<p><strong>Background: </strong>Our study aimed to comprehensively assess the impact of type II diabetes mellitus (T2DM) on oral health-related quality of life (OHRQoL) based on results from the Oral Health Impact Profile (OHIP-14) questionnaire. A secondary objective was to explore how the potential correlation between the OHIP-14 score and T2DM was affected by demographic and clinical characteristics.</p><p><strong>Methods: </strong>We systematically searched the Medline, EMBASE, CINAHL and Scopus databases on January 24, 2024, for evidence starting from database inception. Studies included in the analysis assessed OHRQoL in T2DM patients. We searched trials both with or without comparisons to healthy controls and presenting OHIP-14 results as a severity of impact, namely, the mean OHIP-14 total score. To assess the difference between diabetic and non-diabetic subjects, we calculated weighted mean differences (WMD) with 95% confidence intervals (CI). A meta-analysis of each summary measure was conducted provided that this outcome was evaluated in at least two studies so that model was selected on the basis of heterogeneity assessment. The quality of the included studies was assessed using the tool developed by The National Heart, Lung, and Blood Institute (NHLBI).</p><p><strong>Results: </strong>Seven studies fulfilled the inclusion criteria (1,457 patients diagnosed with diabetes mellitus and 216 healthy controls). In patients with T2DM, the mean OHIP-14 total score was approximately 2.7 points higher (an indication of greater oral problems) than in healthy persons; WMD = 2.68 (95% CI: 0.47-4.89); p = 0.0176. Significant differences between diabetic and non-diabetic subjects were also observed for almost all domains of the OHIP-14, except handicap. The calculated average OHIP-14 total score was 12.06 (95% CI: 4.93-19.19), which indicated a slight effect on OHRQoL. Age and sex did not appear to be relevant for assessing the impact of diabetes mellitus on OHRQoL.</p><p><strong>Conclusions: </strong>Our findings confirm that OHRQoL in patients with T2DM is significantly lower and may be influenced by functional problems in addition to various physical and psychological limitations. However, the available data are of low quality and a lack of evidence from high-quality studies with matched control groups exists.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"485"},"PeriodicalIF":2.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of post-polymerization methods and varying thicknesses on colour stability and flextural strength of denture base polymers produced with stereolithography (SLA) technique.","authors":"Esra Kul, Saba Ostovar, Seyhan Kahraman, Nuran Yanıkoğlu, Faruk Yeşildal","doi":"10.1186/s12903-025-05868-9","DOIUrl":"10.1186/s12903-025-05868-9","url":null,"abstract":"<p><strong>Background: </strong>Limited information is available on the thickness and post-polymerization procedure of denture base resins produced by stereolithography (SLA). This study aims to assess the impact of varying thickness, post-curing durations, and temperature on the flexural strength and colour stability of 3D-printed denture bases.</p><p><strong>Materials and methods: </strong>A total of 80 rectangular specimens, measuring 65 × 10 × 3 mm and 65 × 10 × 2 mm, were developed using 3D-printed acrylic resin. The 3D-printed groups were further categorised based on their thickness into two groups: 2 mm and 3 mm. Each of these four groups was then subdivided based on the post-curing temperature (60 °C and 80 °C) and post-curing duration (15 min and 60 min). To ensure colour stability, the specimens were placed in an incubator containing a coffee solution at a temperature of 37 degrees Celsius. To evaluate the flexural strength of the specimens, they were placed on a specialised jig with two supports that were 50 mm apart. The jig was securely attached to a universal testing machine. The spectrophotometer was used to measure the colour changes (ΔE00) of the specimens that underwent different post-curing procedures and were immersed in coffee. The data analysis involved the use of ANOVA and Tukey's post hoc tests, with a significance level (α) set at 0.05.</p><p><strong>Results: </strong>The study's findings suggest that the flexural strength values exhibited an upward trend as the post-curing periods increased from 15 to 60 min and the temperatures rose from 40 °C to 80 °C. Group 2 and 4 showed the highest flexural strength (86 MPa and 95 MPa, respectively). Group 2 with less thickness than group 4 exhibited a better color stability and acceptable level of color change with ΔΕ00 = 2.59.</p><p><strong>Conclusions: </strong>The study revealed that the specimens with a thickness of 3 mm, a post-curing period of 60 min, and a temperature of 80 °C exhibited the best flexural strength but the lowest colour stability compared to the other groups. Optimum results can be achieved by increasing the post polymerization time and temperature rather than increasing the thickness of the denture base. Because group 2, which has a thickness of 2 mm and is subjected to the same post-curing period, has acceptable clinical results in terms of both flexural strength and color stability.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"488"},"PeriodicalIF":2.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical effects of probiotics on the treatment of gingivitis and periodontitis: a systematic review and meta-analysis.","authors":"Cristina Benavides-Reyes, Inmaculada Cabello, Antonio Magán-Fernández, Miguel Rodríguez-Barranco, Sıla Nur Usta, Francisco Mesa","doi":"10.1186/s12903-025-05888-5","DOIUrl":"10.1186/s12903-025-05888-5","url":null,"abstract":"<p><strong>Aims: </strong>This study aimed to evaluate the impact of probiotics as an adjunct to periodontal therapy on clinical outcomes in patients with gingivitis and periodontitis through a meta-analysis of available evidence.</p><p><strong>Materials and methods: </strong>A detailed bibliographic search on four databases (PubMed, Scopus, Cochrane and EMBASE) was conducted with a language restriction. The collected data were assessed according to the predefined eligibility criteria and randomized clinical trials reporting the effects of probiotics on plaque index (PI), bleeding on probing (BOP) and pocket probing depth (PPD) compared to control or placebo groups were selected and analysed. The risk of bias assessment was conducted using SYRCLE's RoB- 2 tool. The GRADEpro tool was used to determine the overall quality of evidence.</p><p><strong>Results: </strong>Twenty-four studies (10 about gingivitis and 14 about periodontitis) were included in the meta-analysis. In the gingivitis studies, lower but non-significant PI and BOP were found in the probiotic group. In periodontitis, lower PI (95%-CI [- 0.54; - 0.15], p = 0.001) were reported in the probiotic group, and this difference was greater in studies with longer follow-up. Lower BOP (95%-CI [- 0.58; - 0.05], p = 0.021) was also reported, but this difference was only significant in studies with a shorter follow-up (95%-CI [- 0.86; - 0.11], p = 0.012). Meta-analysis for PPD showed lower, but non-significant, values (95%-CI [- 0.53; + 0.03], p = 0.077). However, this difference became significant when assessing studies with shorter follow-up (95% CI [- 0.77; - 0.07], p = 0.019).</p><p><strong>Conclusions: </strong>The meta-analysis provides evidence suggested that probiotics can serve as a beneficial adjunct to periodontal treatment in patients with periodontitis, particularly in improving clinical outcomes such as plaque index and bleeding on probing. The results from gingivitis studies highlight the need for further investigation to better understand the impact of probiotics in the early stages of periodontal disease. These findings emphasize the importance of future research with standardized protocols and longer follow-up periods to confirm and expand on the clinical utility of probiotics in periodontal therapy.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"490"},"PeriodicalIF":2.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of combined dynamic navigation system and dental operating microscope on the accuracy and efficiency of fiber post removal: an in vitro study.","authors":"Sirinya Kulvitit, Thamasorn Eamtanaporn, Phonkit Sinpitaksakul, Patcharapit Promoppatum, Suppakrit Khrueaduangkham, Thantrira Porntaveetus","doi":"10.1186/s12903-025-05887-6","DOIUrl":"10.1186/s12903-025-05887-6","url":null,"abstract":"<p><strong>Background: </strong>There is limited information concerning the effectiveness of the combined dynamic navigation system (DNS) and dental operating microscope (DOM) technique in fiber post removal. The aim of this study was to assess the effectiveness of the DNS-DOM technique for fiber post removal compared with the freehand technique (FH)-DOM.</p><p><strong>Methods: </strong>In a phantom head-based study, 30 human mandibular teeth were utilized, with 7 mm of fiber post left in obturated canals. Under a DOM, an experienced endodontist, employing an ET18D ultrasonic tip under a rubber dam, removed the fiber posts using either FH or DNS. Pre- and post-operative CBCT scans were taken, and 3D models were reconstructed with Materialise Mimics software. Accuracy (deviation volume, distance, angle, position) and efficiency (procedure time) parameters were analyzed. Normality was assessed with the Shapiro-Wilk test, utilizing the independent samples t-test for normally distributed data and the Mann-Whitney U test for non-normally distributed data.</p><p><strong>Results: </strong>The DNS-DOM and FH-DOM groups demonstrated comparable results in deviation volume, percent deviation volume, maximum deviation distance, deviation angle, and maximum deviation position-all accuracy-related factors. We noted higher deviation and percent deviation volumes in DNS-DOM, which were not significant, compared with FH-DOM in incisors. Conversely, in molars, FH-DOM exhibited higher values than DNS-DOM, suggesting that the free-hand technique may result in less deviation under better visibility. There was a consistent trend of a higher deviation angle for DNS-DOM compared with FH-DOM across all tooth types. DNS-DOM and FH-DOM displayed a higher deviation angle in molars than in premolars and incisors. The distance between maximum deviation points and initial drilling points was smaller in molars compared with incisors and premolars. Regarding efficiency, the DNS-DOM group demonstrated a significantly longer procedure time (8 min) compared with FH-DOM. Fiber post removal time followed a similar trend in both groups, being fastest in molars, followed by premolars and incisors.</p><p><strong>Conclusions: </strong>DNS-DOM showed accuracy comparable to FH-DOM in fiber post removal when performed by an experienced endodontist with appropriate ultrasonic tips. However, DNS-DOM had a longer procedure time, potentially reducing efficiency due to the additional navigation system integration, demanding increased operator operating time.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"482"},"PeriodicalIF":2.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The salivary metabolomics analyses reveal the variable metabolites in distinct staging of periodontitis.","authors":"Lijun Wang, Wen Lu, Wei Ju, Wenxin Yao, Chaowen Shi, Xihu Yang, Wenhao Qian","doi":"10.1186/s12903-025-05792-y","DOIUrl":"10.1186/s12903-025-05792-y","url":null,"abstract":"<p><strong>Objective: </strong>Saliva, which is a critical component of the oral ecosystem, undergoes dynamic changes, particularly during the onset and progression of periodontitis.</p><p><strong>Subjects and methods: </strong>This study used Gas Chromatography-Mass Spectrometry (GC-MS), a reliable and high-throughput tool for metabolomic analysis, to detect salivary metabolic shifts across various stages of periodontitis (T1-T4). We compared differential changes in metabolites between the HC and T1 groups, the T1 and T2 groups, the T2 and T3 groups, and the T3 and T4 groups.</p><p><strong>Results: </strong>By analysing saliva samples from 116 individuals-10 healthy controls (HC) and 106 patients with periodontitis across stages T1 (22 individuals) to T4 (28 individuals), we identified differential metabolites including Glucose, 3-Aminobutanoic Acid, N-(1-Cyclopropylethyl) Aniline, and Methylmalonic Acid. Compared to HC, the metabolites in patients with periodontitis exhibited progressive concentration changes correlating with the severity of the disease. Furthermore, KEGG pathway analysis was used to elucidate the metabolic pathways involved in the development of periodontitis.</p><p><strong>Conclusions: </strong>Our findings demonstrate the potential of salivary metabolites as biomarkers for monitoring periodontitis progression and offer valuable insights into its pathogenesis and potential therapeutic targets.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"480"},"PeriodicalIF":2.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does intra-articular injection of PRP help patients with temporomandibular joint osteoarthritis after joint puncture? a systematic review and meta-analysis of randomized controlled trials.","authors":"Feng Xu, Juanjuan Zhang, Iingzhi Wu, Youfu Xu, Taochun Yu, Jiliang Kang, Feiyan Wu","doi":"10.1186/s12903-025-05826-5","DOIUrl":"10.1186/s12903-025-05826-5","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to conduct a systematic review to evaluate whether intra-articular injection of platelet-rich plasma (PRP) after joint puncture can aid in the recovery of patients with temporomandibular joint osteoarthritis (TMJOA).</p><p><strong>Methods: </strong>We searched PubMed, Cochrane Library, Embase and Web of Science as of March 3, 2024. Retrieved a total of 392 articles. We included all published randomized controlled trials (RCTs). All RCTs, including studies on PRP injection after joint puncture in patients with TMJOA. The primary outcome was pain reduction, and the secondary outcome was the improvement of maximal mouth opening (MMO) and joint sounds. All outcome measures were analyzed by calculating the standardized mean differences (SMDs) and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>A total of 392 articles were retrieved, and ultimately, 6 articles met the inclusion criteria. The study involved 199 TMJOA patients. The results indicated that compared to the control group, PRP injection after joint puncture showed significant improvements in alleviating pain (SMD =-0.99; 95% CI =-1.35 ~-0.63; P <0.00001, I² = 59%) and MMO (SMD = 0.63; 95% CI = 0.30 ~ 0.95; P <0.0002, I² = 54%) among TMJOA patients. However, there was no significant improvement observed in terms of joint sounds (SMD =-0.34; 95% CI = -0.71 ~ 0.02; P = 0.06, I² = 0%) with the PRP.</p><p><strong>Conclusions: </strong>Compared to joint puncture alone, the intra-articular injection of PRP after joint puncture was more effective in relieving pain. At 1-month and 6-month follow-ups, patients in the PRP group showed significant improvements in MMO compared to the control group. However, after 12 months of follow-up, limited evidence indicated significant improvements in MMO and joint sounds.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"475"},"PeriodicalIF":2.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wear volumes of flowable and sculptable resin composite attachments and their correlation with retentive force of clear aligners: a laboratory study.","authors":"Nuttakan Roatkanjanaporn, Janeta Chavanavesh, Chutimont Teekavanich","doi":"10.1186/s12903-025-05852-3","DOIUrl":"10.1186/s12903-025-05852-3","url":null,"abstract":"<p><strong>Background: </strong>Aligner attachment integrity is important for clear aligner retention and overall treatment efficacy. This study aimed to evaluate the wear volume of clear aligner attachments and the retentive force change of clear aligners over a simulated 24-week insertion/removal period, along with their correlation.</p><p><strong>Methods: </strong>Attachments made from Tetric N-Flow (flowable), Beautifil Injectable X (flowable), or Filtek™ Z350 XT (sculptable) resin composites (n = 6 each) were bonded to the first premolars of maxillary dental resin models. Each model underwent a simulated 3-cycle daily insertion and removal of 12 clear aligners, with each aligner tested for 14 days, using a universal testing machine. Attachment wear volume was quantified through 3D scanning and superimposition. Average daily retentive force of aligners was measured. Data were analyzed using mixed-design ANOVA to evaluate differences in retentive force and wear volume among composites, and Pearson's correlation to assess the relationship between wear and retentive force change. Statistical significance was set at p < 0.05.</p><p><strong>Results: </strong>Significant attachment wear was observed primarily in gingival regions, without significant differences in wear volume among the three composites. Retentive force decreased significantly from days 1 to 2 and continued to decline until day 14 (p < 0.01), without significant differences in retentive force among aligners nor composite types. No significant correlation was found between attachment wear volume and the retentive force difference between the 1st and 12th aligners.</p><p><strong>Conclusions: </strong>Despite reductions in attachment volume across all three composites over the 24-week period, no significant change in mean retentive force among aligners was observed. The tested composites demonstrated comparable wear resistance during repeated aligner insertion and removal over 24-week, with stable aligner retentive force, supporting their feasibility for use in clear aligner therapy.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"483"},"PeriodicalIF":2.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of educational video intervention to improve oral health knowledge and beliefs among physicians and nurses.","authors":"Balgis Osman Gaffar, Abdulrahman Alkhaldi, Turki Alshehri, Raand Altayyar, Faraz Ahmed Farooqi, Eman Bakhurji, Jorma I Virtanen","doi":"10.1186/s12903-025-05685-0","DOIUrl":"10.1186/s12903-025-05685-0","url":null,"abstract":"<p><strong>Background: </strong>The most prevalent dental diseases have adverse effects on an individual's general health. To address this public health crisis and oral health disparity, collaborative efforts of health professionals are critical for dental disease prevention and optimal oral health. This study evaluated the effect of an educational video intervention on oral health knowledge, beliefs, and practices of physicians and nurses.</p><p><strong>Methods: </strong>This pre-post interventional study evaluated the immediate effects of a video-based oral health educational intervention given to nurses and physicians in Saudi Arabia. A self-administered questionnaire was distributed to participants to assess their oral health (OH) knowledge, beliefs, and practices of OH care. The study participants (physicians and nurses) were randomly exposed to two intervention groups (video or brochure) after which they responded to a post interventional survey. Means of knowledge and beliefs scores were calculated before and after the intervention. Logistic regression was applied to investigate the factors associated with good knowledge and beliefs after the educational intervention.</p><p><strong>Results: </strong>A total of 213 healthcare providers of whom 56% were physicians participated in this study. Knowledge of OH improved significantly (p < 0.001) after the intervention and was higher among females compared to males (16.86 to 19.54). The physicians showed more improvement post intervention compared to nurses (19.76 vs. 19.30, respectively) (p < 0.001). The overall belief scores for providing OH education did not change significantly post intervention (p = 0.545). Providing OH care to the patients and conducting an OH screening increased moderately after the intervention (44.6-55.4% and 44.6-55.4%, respectively).</p><p><strong>Conclusion: </strong>The video-based intervention was effective in improving the physicians' and nurses' knowledge, beliefs, and likelihood to incorporate OH care in their current practices. Males, Saudis, working in academia and more work experience were significantly associated with greater odds of having good knowledge after the intervention regardless of its type.</p><p><strong>Clinical trial number: </strong>Not Applicable.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"479"},"PeriodicalIF":2.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary lipid metabolism in periodontitis patients with spleen-stomach dampness-heat syndrome.","authors":"Chunting Lu, Yijue Wang, Zhanyu Huang, Keyin Mo, Zejian Li","doi":"10.1186/s12903-025-05847-0","DOIUrl":"10.1186/s12903-025-05847-0","url":null,"abstract":"<p><strong>Background: </strong>Spleen-stomach damp-heat syndrome is one of the most common syndrome types in periodontitis from traditional Chinese medicine theory. However, its pathological mechanism is still uncertain. Tissue metabolism is driven by microbes in the host and its microenvironment. Hostmicrobe-metabolism is an interacting and closely related complex. Lipid metabolomics can find lipid metabolites in disease or healthy state, which is beneficial to explore the metabolic process and change mechanism of lipids that may be involved in organisms in healthy or disease state from the perspective of systems biology.</p><p><strong>Methods: </strong>In this study, 10 patients in the periodontitis group (CP), 10 patients in the periodontitis with spleen-stomach dampness-heat syndrome group (SP) and 10 patients in the healthy group (H) were recruited for participation, whose unstimulated saliva was collected. The differential metabolites between the groups were detected by ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and screened out based on the variable importance in projection (VIP) combined with the P-value and fold change (FC) value of univariate analysis. Finally, KEEG pathway enrichment analysis was performed on these differential metabolites.</p><p><strong>Results: </strong>A total of 1131 metabolites were detected in saliva in this study. 497 metabolites were significantly up-regulated in periodontitis, mainly plasma-membrane-associated lipids, unsaturated fatty acids and oxidized lipids. Compared with the healthy group, the lipid metabolism pathways of periodontitis with or without spleen-stomach dampness-heat syndrome group were mainly characterized by significant enrichment of glycerophospholipid metabolism and unsaturated fatty acid metabolism such as arachidonic acid metabolism.</p><p><strong>Conclusion: </strong>Compared with periodontally healthy patients, periodontitis with or without spleen-stomach dampness-heat syndrome can cause changes in lipid metabolism in saliva samples of patients. These metabolites are mainly plasma membrane lipids, unsaturated fatty acids and oxidized lipids quality. These lipids may be potential biomarkers of periodontitis. The downstream metabolites of unsaturated fatty acids in the saliva samples of patients with periodontitis and spleen-stomach dampness-heat syndrome were abnormal, and the oxidized lipid (±)5-HETE was significantly abnormal. We speculate that this may be related to the increased state of oxidative stress in saliva samples in disease states.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"476"},"PeriodicalIF":2.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of accuracy and membrane perforation in robotic-assisted implant surgery for transalveolar sinus floor elevation: a retrospective case series.","authors":"Tao Yang, Wenjing Yi, Wenan Xu, Xiaojian Xing, Buling Wu","doi":"10.1186/s12903-025-05848-z","DOIUrl":"10.1186/s12903-025-05848-z","url":null,"abstract":"<p><strong>Background: </strong>The potential of the robotic system for transalveolar sinus floor elevation (TSFE) with simultaneous implant placement has not been verified. This study aimed to assess implant placement accuracy and membrane perforation in robotic computer-assisted implant surgery (r-CAIS) for TSFE.</p><p><strong>Methods: </strong>Patients who underwent r-CAIS for TSFE were enrolled in this study. Positioning markers were placed in the patient's oral cavity, and cone-beam computed tomography (CBCT) was performed. Subsequently, the surgical plan was generated using robotic software. After the markers were registered with the robotic arm, TSFE and implant placement were performed using the robotic arm and crestal approach sinus (CAS) kit drills under the control of the surgeons. Deviations between the planned and placed implants were assessed using preoperative and postoperative CBCT data. In addition, perforation of the Schneiderian membrane was evaluated intraoperatively using the Valsalva maneuver and postoperatively using CBCT images.</p><p><strong>Results: </strong>Ten patients were enrolled, and no adverse events occurred during the surgery. The mean global coronal, global apical, and angular deviations were 0.55 ± 0.20 mm (95% confidence interval [CI]: 0.41 to 0.69 mm), 0.56 ± 0.23 mm ( 95%CI:0.40 to 0.73 mm), and 1.38 ± 0.83° ( 95%CI: 0.78 to 1.97°), respectively. No membrane perforation was observed during or after the surgery.</p><p><strong>Conclusions: </strong>Within the limitations of this study, r-CAIS for TSFE showed high accuracy and a low membrane perforation rate.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"474"},"PeriodicalIF":2.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}