BMC Oral Health最新文献

{"title":"Association of periodontitis, tooth loss, and self-rated oral health with circadian syndrome in US adults: a cross-sectional population study.","authors":"Yibo Li, Yuhao Liu, Tao Yin, Mi He, Changyun Fang, Xiong Tang, Shifang Peng, Yundong Liu","doi":"10.1186/s12903-025-06078-z","DOIUrl":"10.1186/s12903-025-06078-z","url":null,"abstract":"<p><strong>Background: </strong>This study was to investigate associations of periodontitis, tooth loss and self-rated oral health with circadian syndrome.</p><p><strong>Methods: </strong>Data regarding periodontitis, dentition, oral health questionnaire and circadian syndrome of 30-85 years old participants from US National Health and Nutrition Examination Survey 2005-2020 were analyzed. Periodontitis questions for periodontitis and dentition status were validated. Weighted multivariable logistic regression analyses were used.</p><p><strong>Results: </strong>Weighted prevalence of circadian syndrome and stage II-IV periodontitis was 33.29% and 88.87%, respectively. When compared with stage I periodontitis, stage II periodontitis was significantly associated with greater circadian syndrome prevalence after adjustment (odds ratio (OR) and 95% confidence interval (CI): Stage II: 1.35 (1.03, 1.76), P = 0.032; Stage III: 1.30 (0.97, 1.73), P = 0.069; Stage IV: 1.17 (0.82, 1.65), P = 0300). Stage II periodontitis was significantly associated with greater prevalence of lower high-density lipoprotein cholesterol (HDL) and elevated triglycerides and stage III and stage IV periodontitis were significantly associated with greater hypertension prevalence. A 1 tooth increase in the number of missing teeth was associated with a 1% increase in circadian syndrome and its components of obesity, elevated fasting plasma glucose (FPG) and short sleep. Poor or fair self-rated oral health showed a specificity of > 70% for periodontitis and lack of functional dentition. Meanwhile, poor or fair self-rated oral health had relatively higher levels of sensitivity for stage II-IV periodontitis (35%), stage III-IV periodontitis (46%), stage IV periodontitis (60%) and lacking functional dentition (56%). When compared to excellent self-rated oral health, good, fair and poor self-rated oral health were significantly associated with higher circadian syndrome prevalence (OR and 95% CI: Very good: 1.13 (0.97, 1.32), P = 0.120; Good: 1.34 (1.14, 1.57), P < 0.001; Fair: 1.41 (1.16, 1.71), P = 0.001; Poor: 1.63 (1.32, 2.03), P < 0.001). Additionally, participants with worse self-rated oral health had significantly higher prevalence of elevated FPG, hypertension, low HDL, elevated triglycerides, short sleep and depression.</p><p><strong>Conclusions: </strong>Periodontitis, tooth loss and worse self-rated oral health were associated with circadian syndrome in US adults. Self-rated oral health may be a simple question to indicate oral and systemic health.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"713"},"PeriodicalIF":2.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of RAFT-based and conventional bulk-fill composites cured with conventional and high irradiance photocuring: a comparative study.","authors":"Noura Arafa, Dalia I Sherief, Lamia M Elmalawanya, Mohamed S Nassif","doi":"10.1186/s12903-025-06046-7","DOIUrl":"10.1186/s12903-025-06046-7","url":null,"abstract":"<p><strong>Background: </strong>Understanding the impact of advanced photocuring and composite formulations for clinical outcomes and restoration durability. This study evaluated the degree of conversion (DC), polymerization shrinkage strain, and flexural properties (Flexural strength and modulus) of conventional and RAFT-based bulk-fill resin composites cured with conventional and high-irradiance ultra-fast photocuring.</p><p><strong>Methods: </strong>A total of 80 specimens of a RAFT-based bulk-fill resin composite (Tetric PowerFill, TP, Ivoclar Vivadent AG Bendererstrasse 2 9494 Schann/Liechtenstein) and a conventional bulk-fill composite (Tetric N-Ceram, TN, Ivoclar Vivadent AG 9494 Schaan/Liechtenstein) were cured using two protocols: high irradiance ultra-fast mode (2700 mW/cm² for 3 s) and conventional mode (900 mW/cm² for 20 s). The DC was measured using FTIR Spectroscopy(Thermo-Nicolet 67,000, USA), and the polymerization shrinkage strain was quantified with a polyimide-backed electrical resistance strain gauge using a strain meter (PCD-300A Kyowa-Electronic Instruments Co, LTD, Tokyo, Japan). Flexural strength σ_f (MPa) and modulus E_f (MPa) were assessed using 3-point loading in a universal testing machine (Instron 3365, Norwood, MA, USA, with a maximum load capacity of 5 kN) immediately after curing and after thermal aging (10,000 cycles). Results were analyzed using multi-factorial ANOVA with a significance level set at (p ≤ 0.05).</p><p><strong>Results: </strong>The DC for TP showed no significant differences between curing modes, with values of 57.82% in fast mode and 55.3% in conventional mode. Similarly, its mechanical properties remained relatively consistent, with σf measuring 121.66 MPa in fast mode and 137.5 MPa in conventional mode, while the Ef was 6078.50 MPa and 6167.26 MPa, respectively. In contrast, TN exhibited a lower DC in fast curing (50.27%) compared to conventional curing (61.5%). However, its mechanical properties remained nearly unchanged, with σf recorded at 135.34 MPa in fast mode and 137.26 MPa in conventional mode, and Ef at 6356.54 MPa and 6857.2 MPa, respectively. Moreover, TP showed greater resistance to mechanical property degradation after thermal aging compared to TN.</p><p><strong>Conclusions: </strong>The RAFT-based bulk-fill composite performed comparably to the conventional composite in both curing modes while demonstrating greater durability. However, fast curing of the conventional bulk-fill composite resulted in unacceptable properties, underscoring the importance of selecting appropriate materials and curing protocols to ensure long-lasting restorations.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"714"},"PeriodicalIF":2.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and evaluation of a multimedia oral health education software for teenagers.","authors":"Maryam Bakhtiar, Seyed Mohammad Hosseini, Arghavan Behbahanirad, Amirhossein Kamyab, Ali Khani Jeihooni","doi":"10.1186/s12903-025-06083-2","DOIUrl":"10.1186/s12903-025-06083-2","url":null,"abstract":"<p><strong>Background: </strong>Maintaining good oral and dental hygiene is one of the most crucial components of a healthy lifestyle. Health education is implemented through various techniques, such as lectures, movie screenings, printed materials, etc. This study aimed to develop a multimedia teaching instrument for oral and dental health education and assess its effectiveness in raising teenagers' knowledge and satisfaction.</p><p><strong>Methods: </strong>the research's sample size included 70 teenagers, who were chosen randomly. The users were given access to the program before and after using the software, and its efficacy was assessed from their perspective using questionnaires. The data analysis was performed using descriptive statistics indices and analytical tests, SPSS version 26. A significance level of 0.05 was considered.</p><p><strong>Results: </strong>The average age and educational grade of software users were 14.49 years and 8.49 years, respectively. Before using the software, 67.76 ± 19.8% of the questions were answered correctly, while after using the software, 86.85 ± 10.21% of the questions had an accurate response. Before and after utilizing the program, there was an increase of 22.9 ± 17.8% in the mean correct response.</p><p><strong>Conclusion: </strong>Useful training in the mentioned software, along with multimedia content and easy access of teenagers to the training, will facilitate and increase the speed of health education and reduce the time and cost of subsequent oral and dental health disorders.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"712"},"PeriodicalIF":2.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C-shaped root canal systems in the bilateral mandibular first molars: a case report and literature review.","authors":"Rongjing Zhou, Lili Shen, Chengshi Wei","doi":"10.1186/s12903-025-06060-9","DOIUrl":"https://doi.org/10.1186/s12903-025-06060-9","url":null,"abstract":"<p><strong>Background: </strong>Mandibular first molars typically exhibit complex root and canal anatomy. A thorough understanding of their morphological variations is crucial for endodontists to achieve successful root canal treatment. A C-shaped root canal system is a unique anatomical variation characterized by a C-shaped or semi-circular cross-sectional morphology, observed predominantly in mandibular second molars. The prevalence rate of the C-shaped root canal system is approximately 2.7-48.7% in the mandibular second molar, while the condition is rarely seen in mandibular first molars, particularly in bilateral cases.</p><p><strong>Case presentation: </strong>This report details an uncommon case of a C-shaped root canal system in bilateral mandibular first molars: the right molar exhibited a fused root with two separate mesial and two distal canals, while the left molar displayed a single oval mesial canal and a semicolon-shaped distal canal. To our knowledge, this is the first report of the presence of four separate canals within a fused C-shaped root in the mandibular first molar.</p><p><strong>Conclusions: </strong>While C-shaped root variations are detected in mandibular first molars, a thorough knowledge of normal root canal anatomy and associated variations presents a significant challenge for clinicians in terms of successful endodontic treatment.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"711"},"PeriodicalIF":2.6,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical performance of post-and-cores of polyetheretherketone and its composites.","authors":"Biyao Wang, Minghao Huang, Kaige Zhang, Yan Xu, Xinwen Zhang, Liye Shi, Xu Yan","doi":"10.1186/s12903-025-06089-w","DOIUrl":"https://doi.org/10.1186/s12903-025-06089-w","url":null,"abstract":"<p><strong>Background: </strong>Polyetheretherketone (PEEK) and its fiber-reinforced composites have been indicated as ideal post-and-cores materials due to its mechanical properties. However, the laboratory evidences of post-and-cores restored with fiber-reinforced PEEK are lacking.</p><p><strong>Materials and methods: </strong>A total of 120 extracted mandibular premolars were treated endodontically and divided into six groups restored with different post-and-core materials (N = 20): (1) prefabricated quartz fiber-reinforced composite (QFRC), (2) polymer-infiltrated ceramic (PIC), (3) cobalt chromium (CoCr), (4) PEEK, (5) 30% glass fiber-reinforced PEEK (GFR-PEEK), and (6) 30% carbon fiber-reinforced PEEK (CFR-PEEK). Stress distribution was analyzed by finite element analysis (FEA). Then, each group was then divided into two subgroups (n = 10): static loading test and fatigue loading test. The static failure load (SFL) was analyzed by one-way analysis of variance (ANOVA) with least-significant difference (LSD) multiple comparison tests. The fatigue failure load (FFL) and cycles for failure (CFF) were evaluated by Kaplan-Meier survival analysis (P < 0.05).</p><p><strong>Results: </strong>Groups PEEK, GFR-PEEK, and CFR-PEEK exhibited lower maximum peak principal stress and better stress distribution than Group CoCr. The SFL of Groups PEEK and QFRC did not differ from each other, and both were lower than those of Groups CoCr, GFR-PEEK, and CFR-PEEK. In the fatigue loading test, Group CoCr exhibited the best survival; however, with the progression of fatigue, the survival probabilities of Groups PEEK and its composites were close to that of Group CoCr. In all groups apart from Group CoCr, the rate of repairable failure modes was higher than that of irreparable ones.</p><p><strong>Conclusions: </strong>Customized post-and-cores manufactured with PEEK and its fiber-reinforced composites showed superior biomechanical performance, making them potential alternatives for the restoration of massive tooth defects.</p><p><strong>Clinical relevance: </strong>This study provides a theoretical basis for clinicians to select post-and-core materials for different root canal morphology residual roots and helps to reduce the occurrence of complications such as root fracture and post core debonding.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"706"},"PeriodicalIF":2.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robot-assisted extraction of impacted mandibular tooth: a clinical report.","authors":"Mirealimu Miadili, Wenbin Zhang, Yan Zhang, Yiming Gao, Halisha Mutalifu, Xiaoman Li, Jianfei Zhang","doi":"10.1186/s12903-025-06094-z","DOIUrl":"https://doi.org/10.1186/s12903-025-06094-z","url":null,"abstract":"<p><strong>Background: </strong>This clinical report presents the use of a minimally invasive, robot-assisted windowing surgery for the extraction of a median impacted mandibular tooth. The report highlights the precision and safety afforded by robotic assistance in performing complex dental procedures. However, this case report also critically examines the challenges associated with robotic systems, including high costs, prolonged setup times, and the need for specialized training. The financial burden and learning curve associated with robotic-assisted surgery are discussed in the context of their implications for widespread clinical adoption.</p><p><strong>Case presentation: </strong>A 24-year-old male patient, in good general health, was diagnosed with a median impacted mandibular tooth, as confirmed by cone-beam computed tomography (CBCT) scans. Preoperative in vitro simulations utilizing a robotic system were conducted to establish optimal surgical parameters and to validate the surgical approach. The robot-assisted windowing surgery was then performed under local anesthesia. The total operative time was approximately 90 min, with no major complications reported. Postoperative imaging at six months confirmed successful healing, and the patient expressed high satisfaction with the outcome. The case underscores the potential of robotic-assisted surgery to achieve precise outcomes while minimizing surgical trauma.</p><p><strong>Conclusions: </strong>Robot-assisted dental surgery has been demonstrated to be a feasible and precise technique for managing complex cases, such as impacted mandibular teeth. This approach enhances visualization, ensures safety, and improves accuracy, supporting its potential as a minimally invasive alternative in both dental and maxillofacial surgeries. However, this case report also highlights the need for further research to address the financial burden, learning curve, and long-term outcomes associated with robotic-assisted procedures. Future studies should focus on cost-effectiveness, comparative efficacy, and the development of more accessible robotic systems to ensure broader clinical adoption.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"710"},"PeriodicalIF":2.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of canine lingual attachments during maxillary arch distalization with clear aligner: a 4D finite element analysis and in vitro simulator study.","authors":"Bochun Mao, Yajing Tian, Hanzhang Zhou, Yan Gu","doi":"10.1186/s12903-025-06109-9","DOIUrl":"https://doi.org/10.1186/s12903-025-06109-9","url":null,"abstract":"<p><strong>Objective: </strong>During the maxillary premolar distalization process in clear aligner (CA) therapy, anterior aligner misfit and mesial displacement of the molars are two common challenges. This study aims to propose a novel attachment design to address these issues and to investigate the biomechanical effects of varying canine tipping angles during treatment.</p><p><strong>Method: </strong>A dual-methodological approach was employed: 1) A four-dimensional finite element model (4D FEM) incorporating automated staging simulation was developed, utilizing iterative computations for long-term tooth movement prediction and thermal expansion algorithms for CA morphology adaptation; 2) An electromechanical orthodontic simulator (OSIM) was implemented for in vitro validation. The study analyzed three canine inclination groups in FEM simulations versus eleven groups in OSIM experiments, with particular focus on lingual attachment biomechanics. The A t-test was used to compare the forces and moments of each tooth between the groups with the same canine tipping angle.</p><p><strong>Results: </strong>The findings from the 4D FEM analysis demonstrated that distally inclined canines provided greater anchorage during premolar distalization (0.27 mm mesial movement for the first molar in -10° group), while mesially inclined canines contributed to more pronounced anchorage loss (0.34 mm mesial movement for the first molar in 10° group). The use of lingual attachments on canines improved the average distalization efficacy of premolars by 1%, 6%, and 7% in the -10°, 0°, and 10° canine tipping groups, respectively. Similarly, the in vitro orthodontic simulator (OSIM) experiment showed a comparable trend in force and moment variations.</p><p><strong>Conclusion: </strong>Both the 4D FEM and OSIM analyses indicted that during the distalization process of premolars, canine lingual attachment significantly reduces the mesial displacement of molars by alleviating the unfitness of CA at anterior teeth area to enhance anterior anchorage. The efficiency of the attachment increased with the greater mesial tipping of canine. Based on the results of this study, it is clinically recommended to place lingual attachments during premolar distalization when the canine mesially tipped more than 4°.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"707"},"PeriodicalIF":2.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of the size and location of the FOVs for CBCT capture of the TMJ.","authors":"Marc Anton Fuessinger, Maximilian Frederik Russe, Leonard Simon Brandenburg, Marc Christian Metzger, Johannes Schulze, Stefan Schlager, Wiebke Semper-Hogg","doi":"10.1186/s12903-025-06081-4","DOIUrl":"https://doi.org/10.1186/s12903-025-06081-4","url":null,"abstract":"<p><strong>Background: </strong>Osseous pathologies of the temporomandibular joint (TMJ) such as degenerative joint disease, trauma, and deformity contribute to orofacial morbidity and are considered a major factor in temporomandibular dysfunction. Cone beam computed tomography (CBCT) is a recommended diagnostic tool in imaging of osseous tissue pathologies. However, CBCT contributes to patient radiation exposure, and limiting the CBCT field of view (FOV) may reduce it. This study aims to investigate the possibility and clinical applicability of optimizing the size and location of the FOVs for CBCT capture of the TMJ.</p><p><strong>Methods: </strong>Three-dimensional CBCT data sets in which the bilateral positions and dimensions of the TMJs were analyzed. A total of 201 data sets with 402 condyles were mapped in relation to the CBCT device. By transformation into a common coordinate space using the device's chin rest as a joint denominator, we were able to determine the optimal size and location for uni- and bilateral capture of the TMJ for both best-case and worst-case scenarios with regard to patient positioning.</p><p><strong>Results: </strong>The minimal FOVs for unilateral capture were H 28.2 mm × R 22.9 mm in the best-case scenario assuming optimal patient positioning and H 47.0 mm × R 28.3 mm in the worst-case scenario with rotational deviation along the transversal axis. For bilateral capture, we determined the best-case FOV as H 24.9 mm × R 66.5 mm and the worst-case FOV as H 42.8 mm × R 66.7 mm.</p><p><strong>Discussion: </strong>This research yields indication-specific FOVs for both uni- and bilateral imaging of the TMJ. Considering the best clinical practices for CBCT imaging, clinically feasible FOV dimensions in consideration of the technical specifications of common CBCT devices can be suggested. The clinical application of the results may help reducing radiation exposure of patients receiving CBCT imaging of the TMJ. The transferability of the present results to other CBCT devices requires further research.</p><p><strong>Trial registration: </strong>The study is registered in the German Trial Register with the number DRKS00026149, 2024/02/21.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"709"},"PeriodicalIF":2.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients' trajectory from tooth loss to dental rehabilitation and living with implant-supported dentures - a qualitative interview study.","authors":"Gabriele Müller-Mundt, Philipp-Cornelius Pott, Lara Prinz, Simone Schaumann, Meike Stiesch, Nils Schneider, Franziska A Herbst","doi":"10.1186/s12903-025-06072-5","DOIUrl":"https://doi.org/10.1186/s12903-025-06072-5","url":null,"abstract":"<p><strong>Background: </strong>Since their introduction, implant-supported dentures have gained increasing popularity and are associated with high expectations. Nevertheless, as with other invasive procedures, implant treatment involves post-surgical risks as well as the risk of long-term complications. The present study aimed at exploring patients' experiences of the entire trajectory of dental implant-treatment, to reach a profound understanding of the patients' perception of the course of their journey from tooth loss to living with implant-supported dentures.</p><p><strong>Methods: </strong>The single-site study employed an exploratory, qualitative design with semi-structured interviews conducted with patients who had received implant-supported dentures for different indications at least one year prior. Thirty-three patients were consecutively recruited by dentists during regular check-ups from March to September 2023 at a German university dental clinic. Interview data were analyzed using deductive-inductive qualitative content analysis.</p><p><strong>Results: </strong>Of the 33 patients five patients did not return the consent-to-contact form, and one withdrew their consent, resulting in a final sample of 27 patients (82%). The participants held high expectations regarding the function, durability, and - in cases involving visible tooth gaps - aesthetic outcomes of their implants. Key concerns influencing treatment decisions included the need for bone augmentation and transplantation, age-related factors, and procedural risks. Notwithstanding the lengthy, stepwise nature of the treatment process, the considerable symptom burden, and the high financial cost, most patients considered the implant treatment worthwhile and felt well informed. With one exception the majority of participants (96.3%) reported that their implant-supported dentures functioned and appeared similar to their natural teeth. However, while satisfied with their implant-supported denture, two participants (7.4%) experienced persistent suffering due to temporomandibular disorder and persistent pain following treatment. The issue of prolonged facial pain has arguably been overlooked in aftercare of these patients.</p><p><strong>Conclusions: </strong>Dental implants are generally viewed as preferred option for oral rehabilitation. The results underline the importance of comprehensive counselling and after care irrespectively of the complexity of the treatment. While iatrogenic complications and the risk of their chronification are rare, careful attention to these risks remains essential. Further research, encompassing prospective longitudinal studies, is needed, given the risk of recall bias.</p><p><strong>Clinical trial registration: </strong>Does not apply.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"705"},"PeriodicalIF":2.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of dental pulp cells-derived small extracellular vesicles on the properties and behavior of dental pulp cells: an in-vitro study.","authors":"Dina A Hammouda, Alaa M Mansour, Ahmed R Zaher, Mohammed E Grawish","doi":"10.1186/s12903-025-06031-0","DOIUrl":"https://doi.org/10.1186/s12903-025-06031-0","url":null,"abstract":"<p><strong>Background: </strong>Dental pulp cells-derived small extracellular vesicles (DPCs-sEVs) had shown immunomodulatory, anti-inflammatory, and tissue function restorative abilities. Therefore, DPCs-sEVs should be considered as a promising regenerative tool for dentin-pulp complex or whole pulp regeneration. This study aimed to evaluate the effect of DPCs-sEVs on the proliferation rate, migration capability, and expression pattern of DPCs for osteo/odontogenic gene markers in comparison with mineral trioxide aggregate (MTA).</p><p><strong>Methods: </strong>DPCs-sEVs were isolated from rats' incisors by ultracentrifugation technique. Immunophenotypic characterization, morphology, size, and protein concentration of DPCs-sEVs were monitored and analyzed using flow cytometry (FC), transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and bicinchoninic acid assay (BCA). In addition, the TSG101, CD63, and the cytosolic protein syntenin of sEVs markers were immunodetected using Western blotting. Cell cultures of DPCs from the third passage were left untreated and considered as a control (group I), whereas other cultured cells were treated with 50 µg/mL DPCs-sEVs (group II), 0.2 mg/mL MTA extract (group III), or their combination (50 µg/mL DPCs-sEVs + 0.2 mg/mL MTA extract (group IV). 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay, transwell migration assay, and real-time polymerase chain reaction were used for assessing proliferation, migration, and specific gene expression patterns.</p><p><strong>Results: </strong>The DPCs-sEVs increased DPCs proliferation, and MTA enhanced their effects. The viability and proliferative capacity of DPCs treated with 50 µg/mL DPCs-sEVs + 0.2 mg/mL MTA-conditioned medium was significantly higher when compared with the other groups. The cell migration was more prominent in the group treated with 0.2 mg/mL MTA-conditioned medium than in the group treated with 50 µg/mL DPCs-sEVs. DPCs treated with 50 µg/mL DPCs-sEVs + 0.2 mg/mL MTA extract showed a significant increase in the migration ability of DPCs in comparison with other ones. Moreover, the combination group showed the greatest expression of dentin sialophosphoprotein (Dspp), osteocalcin (Ocn), collagen type I (Col1), and runt-related transcription factor 2 (Runx2).</p><p><strong>Conclusion: </strong>MTA and sEVs together could be a powerful combination for regenerative endodontics.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"704"},"PeriodicalIF":2.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}