The key target and role of betel nut in oral squamous cell carcinoma.

IF 2.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

BMC Oral Health Pub Date : 2025-07-19 DOI:10.1186/s12903-025-06558-2

Tianyi Zhang, Haofeng Xiong, Liujun Zeng, Zhimin Yang, Xin Hu, Tong Su

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引用次数: 0

Abstract

Background: Betel nut consumption is closely related to oral cancer. This study aimed to explore the crucial target and role of betel nut in oral cancer.

Methods: We used RNA sequencing and protein-protein interaction networks to screen the key target of betel nut in oral cancer. Enrichment analysis was used to explore the role of betel nut. Immunohistochemical analysis was used to identify the expression trend of the key target, and survival analysis was used to explore the prognostic value of the key target. The animal model of oral cancer was used to verify the key target of betel nut.

Results: Firstly, 1108 genes were differentially expressed in oral cancer under the influence of betel nut, which may be involved in "metabolic pathways." Moreover, TP53 was the key target of betel nut and was upregulated, resulting in poor prognosis in patients with oral cancer. Finally, the differential expression and role of TP53 in oral cancer with betel nut were validated by human and animal samples.

Conclusions: In conclusion, we found that TP53 upregulation may be the crucial biological phenomenon in the oral cancer with betel nut, indicating that TP53 may be the key target of betel nut in oral cancer.

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槟榔在口腔鳞状细胞癌中的作用及作用。

背景：食用槟榔与口腔癌密切相关。本研究旨在探讨槟榔在口腔癌中的重要作用靶点和作用。方法：利用RNA测序和蛋白-蛋白相互作用网络技术筛选槟榔在口腔癌中的关键靶点。利用富集分析探讨槟榔的作用。采用免疫组化分析确定关键靶点的表达趋势，采用生存分析探讨关键靶点的预后价值。通过口腔癌动物模型验证槟榔的关键靶点。结果：首先，在槟榔的影响下，1108个基因在口腔癌中差异表达，可能参与了“代谢途径”。此外，TP53是槟榔的关键靶点，其表达上调，导致口腔癌患者预后不良。最后，通过人和动物样本验证了TP53在槟榔口腔癌中的差异表达及其作用。结论：综上所述，我们发现TP53的上调可能是槟榔治疗口腔癌的关键生物学现象，提示TP53可能是槟榔治疗口腔癌的关键靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Oral Health DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.90

自引率

6.90%

发文量

481

审稿时长

6-12 weeks

期刊介绍： BMC Oral Health is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of disorders of the mouth, teeth and gums, as well as related molecular genetics, pathophysiology, and epidemiology.