BMC Oral Health最新文献

{"title":"Association between antiretroviral therapy and dental caries in children and adolescents with HIV: a systematic review and meta-analysis.","authors":"Rubén Aguirre-Ipenza, Anthony Bautista-Pariona, Yolanda Viguria-Chavez, Alejandro Hector Huapaya-Cabrera, Franz Tito Coronel-Zubiate, Sara Antonieta Luján-Valencia, Elda Amaya-Riveros, Heber Isac Arbildo-Vega","doi":"10.1186/s12903-025-06015-0","DOIUrl":"https://doi.org/10.1186/s12903-025-06015-0","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the evidence regarding the association between antiretroviral therapy and dental caries in children and adolescents with HIV.</p><p><strong>Methods: </strong>Searches were conducted in five international databases (PubMed, Scopus, EMBASE, CENTRAL, and LILACS) from the inception of records up to October 2024, including studies that examine the impact of antiretroviral therapy on caries in individuals under 18 years of age. The risk of bias was assessed using the Newcastle-Ottawa Scale. Quantitative synthesis was performed using the inverse variance method or Mantel-Haenszel method, depending on the type of outcome analyzed. Measures of association included odds ratios and mean differences, employing a random-effects model with a 95% confidence interval.</p><p><strong>Results: </strong>A total of 585 studies were identified, of which 17 were selected for qualitative review and 15 were included in the meta-analysis. The meta-analysis revealed a significantly higher risk of dental caries in children and adolescents with HIV undergoing antiretroviral therapy compared to those without the virus (odds ratio of 2.11; 95% CI: 1.41-3.17). Subgroup analysis showed a stronger association in case-control studies and for the DMFT index. The certainty of the evidence according to GRADE was rated as very low.</p><p><strong>Conclusion: </strong>Despite limited certainty, the results suggest that HIV under antiretroviral therapy is associated with a higher risk of dental caries. It is prudent to interpret these results with caution, considering the methodological limitations of the studies. However, given the possible relevance of this association for public health, it is recommended to consider specific dental care protocols for children and adolescents with HIV, as well as the need for preventive strategies integrated into HIV management.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"700"},"PeriodicalIF":2.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Porphyromonas gingivalis outer membrane vesicles augments proliferation and metastasis of oral squamous cell carcinoma cells.","authors":"Yanru Zeng, Yiyang Wang, Xiaona Shi, Yuanhao Zhao, Yue Tang, Shanshan Liu, Xiaofeng Zhu","doi":"10.1186/s12903-025-05937-z","DOIUrl":"https://doi.org/10.1186/s12903-025-05937-z","url":null,"abstract":"<p><strong>Background: </strong>Porphyromonas gingivalis (P. gingivalis) is closely related to Oral squamous cell carcinoma (OSCC), and P. gingivalis outer membrane vesicles (OMVs) is the main pathogenic factor, which is associated with periodontitis, atherosclerosis and other diseases. However, few studies have reported an association between P. gingivalis OMVs and OSCC. The purpose of this study was to establish the clinical relationship between P. gingivalis and OSCC based on clinical samples. Further, the effect of P. gingivalis OMVs on OSCC was observed with cell model in vitro, and the possible molecular mechanism was discussed.</p><p><strong>Methods: </strong>Immunohistochemistry was used to detect the abundance of P. gingivalis in OSCC and its paired paracancer tissues, and to analyze the correlation between P. gingivalis and clinicopathological parameters of patients. P. gingivalis OMVs were isolated to observe its effects on the proliferation and migration of OSCC cell lines. RNA-seq was performed and the expression of differentially expressed genes (DEGs) was detected by real-time quantitative PCR (RT-qPCR) to explore the potential mechnism of P. gingivalis OMVs on OSCC progression.</p><p><strong>Results: </strong>The abundance of P. gingivalis in OSCC was higher than that in para-cancerous tissues, and was positively correlated with the degree of tissue differentiation (P = 0.028), T stage (P < 0.001), and clinical stage (P = 0.011). P. gingivalis OMVs promoted the proliferation and migration of HN6 cells, and promoted the proliferation of CAL27 cells, but had no significant effect on its migration. P. gingivalis OMVs treatment attenuated the expressions of TNFSF15, ZNF292, ATRX, ASPM and KIF20B in CAL27 and HN6 cells.</p><p><strong>Conclusion: </strong>This study suggests that P. gingivalis may be an indicator of poor prognosis for OSCC. P. gingivalis OMVs may down-regulate the expression of TNFSF15, ZNF292, ATRX, ASPM, KIF20B and participate in the occurrence and development of OSCC.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"701"},"PeriodicalIF":2.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of machine learning for the analysis of peripheral blood biomarkers in oral mucosal diseases: a cross-sectional study.","authors":"Huiyu Yao, Zixin Cao, Liangfu Huang, Haojie Pan, Xiaomin Xu, Fucai Sun, Xi Ding, Wan Wu","doi":"10.1186/s12903-025-06095-y","DOIUrl":"https://doi.org/10.1186/s12903-025-06095-y","url":null,"abstract":"<p><strong>Background: </strong>Oral mucosal lesions are widespread globally, have a high prevalence in clinical practice, and significantly impact patients' quality of life. However, their pathogenesis remains unclear. Recent evidences suggested that hematological parameters may play a role in their development. Our study investigated the differences in humoral immune indexes, serum vitamin B levels, and micronutrients among patients with oral mucosal lesions and healthy controls. Additionally, it evaluated a Random Forest machine learning model for classifying various oral mucosal diseases based on peripheral blood biomarkers.</p><p><strong>Methods: </strong>We recruited 237 patients with recurrent aphthous ulcers (RAU), 35 with oral lichen planus (OLP), 67 with atrophic glossitis (AG), 35 with burning mouth syndrome (BMS), and 82 healthy controls. Clinical data were analyzed by SPSS 24 software. Serum levels of immunoglobulins (IgG, IgA, IgM), complements (C3, C4), vitamin B (VB1, VB2, VB3, VB5), serum zinc (Serum Zn), serum iron (Serum Fe), unsaturated iron-binding capacity (UIBC), total iron-binding capacity (TIBC), and iron saturation (Iron Sat) were measured and compared among groups. A Random Forest model was applied to analyze a dataset comprising 319 samples with eight key biomarkers.</p><p><strong>Results: </strong>Significant differences were observed between the oral mucosal diseases groups and controls in the serum levels of VB2, VB3, VB5, zinc, iron, TIBC, and Iron Sat. Specifically, serum levels of VB2 and VB3 were significantly higher in patients compared to controls (*p < 0.05), while levels of VB5, Serum Zn, Serum Fe, TIBC, and Iron Sat were significantly lower (*p < 0.05). No significant differences were found for C3, C4, IgG, IgM, IgA, VB1, and UIBC. The optimized Random Forest model demonstrated high performance, and effectively classified different disease groups, though some overlap between groups was noted. Feature importance analysis, based on the Mean Decrease Accuracy and Gini Index, identified VB2, VB3, Serum Fe, TIBC, and Serum Zn as key biomarkers, indicating their potential in distinguishing oral mucosal diseases.</p><p><strong>Conclusion: </strong>Our study identified significant associations between the contents of VB2, VB3, VB5, Serum Fe, Serum Zn, and other micronutrients and oral mucosal lesions. It suggested that regulating these micronutrient levels could be essential for preventing and curing such lesions. The Random Forest model demonstrated high accuracy (94.68%) in classifying disease groups, emphasizing the potential of machine learning to enhance diagnostic precision in oral mucosal diseases. Future research should focus on validating these findings in larger cohorts and exploring alternative machine-learning algorithms to improve diagnostic accuracy further.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"703"},"PeriodicalIF":2.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare providers' perspectives on the Canadian Caries Risk Assessment Tool implementation in Indigenous pediatric primary care: a qualitative study.","authors":"Olubukola O Olatosi, Robert J Schroth, Daniella DeMaré, Betty-Anne Mittermuller, Maria Manigque, Jeanette Edwards, Maryam S Amin, Alexandra Nicolae, Josée Lavoie, Julianne Sanguins, Prashen Chelikani, Peter D Wong, Jesse Lamoureux, Mary Bertone, Katherine Yerex, Rhonda Campbell","doi":"10.1186/s12903-025-06036-9","DOIUrl":"https://doi.org/10.1186/s12903-025-06036-9","url":null,"abstract":"<p><strong>Background: </strong>Early childhood caries remains a significant public health concern among Indigenous children in Canada. Integrating caries risk assessment (CRA) into primary care settings could improve early detection and intervention.</p><p><strong>Objectives: </strong>This qualitative study explored the barriers to implementing and integrating the Canadian CRA tool into the primary care of First Nations and Métis children in Manitoba, based on the perspectives of non-dental primary care providers (NDPCPs).</p><p><strong>Methods: </strong>Fifty NDPCPs providing care to Indigenous children under six years of age were purposefully selected from ten Indigenous communities in Manitoba, including Winnipeg, Selkirk, St. Laurent, Swan River, Pine Creek, Camperville, and Pine Falls. The study employed an exploratory design, with data collected through eight focus groups and twelve in-depth key informant interviews conducted between April 2023 and September 2024. All interviews were audio-recorded, transcribed verbatim, and analyzed using inductive thematic analysis with NVivo software.</p><p><strong>Results: </strong>Participants included pediatricians, family physicians, public health nurses, nurse practitioners, physician assistants, dietitians, and child development workers, with an average age of 41 years (range: 24-61) and 13 years of practice experience (range: 1-40). Thematic analysis identified four major barriers to integrating the CRA tool: (1) Service provider level - time constraint, scope of practice, documentation/referral pathways, and funding; (2) Community level - oral care not priority, separation of dental and general health, lack of transportation, and healthcare distrust; (3) Caregiver and child level - lack of dental insurance, parental willingness, substituting CRA for dental visit; and (4) Provider training and skills - lack of training on fluoride varnish application and dental screening. Despite these challenges, participants expressed a positive attitude toward receiving training on early childhood caries prevention, fluoride application, and the use of the Canadian CRA tool.</p><p><strong>Conclusion: </strong>This study highlights that NDPCPs in Manitoba recognize the Canadian CRA tool as a valuable resource for improving access to early preventive dental care for First Nations and Métis children. The identified barriers provide critical insights for dental, medical, and allied healthcare providers, offering a foundation for developing strategies, guidelines, and policies to enhance preventive oral health services for Indigenous children in Manitoba.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"708"},"PeriodicalIF":2.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trueness and depth discrepancy of post-space scans using an intraoral scanner: influence of preparation dimensions: an in vitro study.","authors":"Mostafa Shahin Zaki, Cherif Adel Mohsen, Mostafa Elhusseiny Mohamed","doi":"10.1186/s12903-025-06062-7","DOIUrl":"https://doi.org/10.1186/s12903-025-06062-7","url":null,"abstract":"<p><strong>Background: </strong>Intraoral scanning of post spaces offers a potential alternative to conventional impressions, but its effectiveness depends on overcoming limitations influenced by post space dimensions.</p><p><strong>Aim of the study: </strong>This study aimed to evaluate the trueness and depth discrepancy percentage of scanned post spaces with different dimensions using an intraoral scanner.</p><p><strong>Materials and methods: </strong>Twenty single-rooted human maxillary canines were endodontically treated. Teeth were assigned to two post space preparation width groups: N (Ø1.5 mm) and W (Ø1.7 mm) (n = 10 per group). Each width group was further subdivided into two depth subgroups: S (6 mm) and L (10 mm) (n = 5 per subgroup). This resulted in four experimental subgroups: NS (Ø1.5 mm, 6 mm), NL (Ø1.5 mm, 10 mm), WS (Ø1.7 mm, 6 mm), and WL (Ø1.7 mm, 10 mm). Specimens were scanned using the Panda P2 intraoral scanner (IOS), and the obtained STL files were aligned and compared with those from traditional impressions scanned with the InEos X5. Trueness and depth discrepancy percentage were evaluated using reverse engineering software. The data were statistically analysed using a Two-Way ANOVA, followed by multiple pairwise comparisons using Tukey's HSD for each individual factor.</p><p><strong>Results: </strong>Preparation width had no significant effect on trueness (p > 0.05), whereas increasing preparation depth significantly reduced it. Additionally, a greater preparation width significantly decreased the depth discrepancy percentage, while increasing preparation depth led to a significant increase. A statistically significant, very strong positive correlation was observed between RMS and depth discrepancy percentage (r = 0.898), indicating that greater deviations in trueness were associated with increased depth discrepancies.</p><p><strong>Conclusions: </strong>Within the study's limitations, trueness improved by reducing post space depth and remained clinically acceptable for all subgroups. However, increasing depth to 10 mm raised the depth discrepancy beyond the clinically acceptable range, while decreasing width also increased discrepancy.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"702"},"PeriodicalIF":2.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of oral HPV in healthy and lesion-bearing populations in Iran: a systematic review and meta-analysis.","authors":"Mohammadreza Kashefi Baher, Anahita Moscowchi, Saede Atarbashi-Moghadam","doi":"10.1186/s12903-025-06085-0","DOIUrl":"https://doi.org/10.1186/s12903-025-06085-0","url":null,"abstract":"<p><strong>Background: </strong>Human papillomavirus (HPV) is a prevalent sexually transmitted virus associated with various oral lesions. While oral HPV infections are common, there is a lack of comprehensive data on its prevalence in regions like Iran. This study aims to assess the prevalence of oral HPV infection in the Iranian population, comparing healthy individuals to those with oral lesions, including oral squamous cell carcinoma (OSCC), oral potentially malignant disorders (OPMDs), and benign lesions.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted following PRISMA guidelines. A comprehensive search was performed across PubMed, Scopus, and Web of Science, supplemented by manual search using google scholar and observational studies (case-control, cross-sectional, and case series) were included if they reported the prevalence of oral HPV infection in Iran. Data synthesis performed to calculate pooled prevalence rates, subgroup analyses by lesion type, and HPV subtype distribution.</p><p><strong>Results: </strong>Of 85 screened studies, 48 were included in the qualitative synthesis, with 36 focused on lesion-bearing patients and 19 on healthy individuals. The overall prevalence of oral HPV infection was 18.3%, with a higher prevalence in lesion-bearing patients (27.1%) compared to healthy individuals (8.2%). The highest prevalence was observed in patients with OSCC (22.7%) and OPMDs (31.2%). HPV-16 was the most common subtype in both groups. A meta-regression analysis revealed a significant association between female sex and HPV detection. Comparative analysis showed significantly higher odds of HPV detection in individuals with oral lesions (OR = 4.78).</p><p><strong>Conclusions: </strong>Oral HPV infection is significantly more prevalent in individuals with oral lesions, especially for HPV-16 and HPV-18. This highlights the importance of HPV in oral health and underscores the need for multidisciplinary efforts to optimize interventions and reduce HPV-related oral disease burden, particularly in regions like Iran.</p><p><strong>Trial registration: </strong>This study is registered with PROSPERO (Registration No. CRD42025641087).</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"699"},"PeriodicalIF":2.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of oral microbiologic profile in children with Type 1 Diabetes Mellitus versus healthy controls and its relation to oral health status.","authors":"Wedad M Nageeb, Asmaa Ali Emam Abo-Elsoud, Mona Karem Amin, Tarek Mohamed Nabil Mohamed Kamel Mahmoud, Noha El-Sayed Fathi Abdou","doi":"10.1186/s12903-025-06013-2","DOIUrl":"https://doi.org/10.1186/s12903-025-06013-2","url":null,"abstract":"<p><strong>Background: </strong>Oral health is a key indicator of one's overall health and is vitally affected by systemic diseases. A bidirectional relationship is assumed to exist between oral health and Type 1 Diabetes Mellitus. Differences in oral cariogenic microbes and their relation to metabolic control show inconsistent results. Additionally, the relation between diabetes and dental caries is inconclusive. The aim of the present study is to investigate the relation of oral health to microbiologic profile in youngsters with Type 1 Diabetes Mellitus.</p><p><strong>Methods: </strong>Sixty-three children were recruited including 22 diabetic children with poor glycemic control, 18 diabetic children with good glycemic control and 23 non-diabetic children. Oral health status was assessed using Caries Assessment Spectrum and Treatment (CAST) and oral hygiene index simplified (OHIS). Salivary and plaque samples were collected and microbiologically analyzed for identification and live colony counting of Mutans Streptococci, Lactobacilli, and different Candida species. The relation of different oral pathogen types and abundances with caries status and diabetes severity was assessed.</p><p><strong>Results: </strong>Salivary Mutans Streptococci were isolated at the rate of 82.5%, lactobacilli at the rate of 74.6%, C. albicans at the rate of 58.7%, and other Candida species collectively at the rate of 46%. The occurrence of salivary Mutans Streptococci was significantly higher in uncontrolled cases compared to healthy subjects. Salivary C. albicans occurred at a significantly lower frequency among controlled cases. C. dubliniensis and C. tropicalis occurred more frequently in the saliva of children with poor glycemic control. We observed higher counts of plaque Mutans Streptococci in children with poorer oral hygiene and poorer glycemic control. Both salivary and plaque C. albicans counts were higher in worse caries status regardless of glycemic status. Salivary Lactobacillus count appears as a marker of caries status.</p><p><strong>Conclusion: </strong>Although diabetes did not show significant effect on increasing risk of dental caries, the oral microbiologic profile was different among healthy and diabetic children and was affected by the level of glycemic control.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"698"},"PeriodicalIF":2.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the effects of different denture base fabrication techniques and hard relining resin materials on the fixation of immediate provisional hybrid prosthesis to titanium cylinders.","authors":"Burcu Kanat-Ertürk, Cansu Akarsu, Önjen Tak","doi":"10.1186/s12903-025-05862-1","DOIUrl":"https://doi.org/10.1186/s12903-025-05862-1","url":null,"abstract":"<p><strong>Background: </strong>Denture base fabrication techniques and hard relining resins play critical roles in the clinical durability of implant supported immediate provisional hybrid prostheses (IPHPs). This study aimed to investigate the effects of different denture base fabrication techniques and hard relining resins on the fixation of IPHPs to titanium cylinders using a push-out test, and observe the failure types.</p><p><strong>Methods: </strong>A total of 140 denture base acrylic resin specimens (diameter: 24 mm, height: 4 mm) were fabricated using four techniques: milling, 3D printing, injection molding, and conventional heat-polymerization. Holes in 10 mm diameter were drilled at the center of each specimen using an industrial drill. Then, titanium cylinders (Opus Implant) were fixed to the specimens using five hard relining resin materials: acrylic resin-based (Ufi Gel Hard)(UGH), heat-polymerized acrylic resin (Futura Basic Hot)(FBH), autopolymerizing composite resin (Quick Up)(QP), autopolymerizing denture repair resin based on diacrylate (Qu-resin)(QR), and autopolymerizing low shrinkage modelling acrylic resin (Pattern resin LS)(PR) (n = 7). Following 5000 thermal-cycles, a push-out test was performed using a universal testing machine (Test Control Systems). Data were statistically analyzed with two-way analysis of variance (ANOVA) and Tukey post-hoc test (SPSS26, p =.05).</p><p><strong>Results: </strong>Denture base fabrication techniques, hard relining resin materials, and their interactions had significant effects on the push-out forces (p <.001). Statistically significant differences among fabrication techniques were observed only in the QR group (p <.05), where heat-polymerization technique had the highest push-out forces. Among relining materials, PR exhibited the highest values for milling technique (p <.05). For 3D printing, PR (p =.007) and QR (p =.029) showed significantly higher values than UGH. For injection molding, PR was superior to QP (p =.012) and UGH (p =.001). For heat-polymerization technique, QR, PR and QP exhibited the higher values (p <.05). The most common failure type was adhesive failure between titanium cylinders and relining resins (ADHES-ti).</p><p><strong>Conclusions: </strong>Denture base fabrication techniques and relining resin types had significant effects on the push-out force. Conventional heat-polymerization technique provided the most consistent performance, whereas milling and 3D printing required careful selection of relining materials. These results can inform clinical decisions to improve IPHP durability and reduce complications.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"697"},"PeriodicalIF":2.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of preoperative apical periodontitis, treatment indications, and methods in endodontically treated teeth: a retrospective study.","authors":"Hüseyin Gündüz, Züleyha Baş, Aslı Zeynep Kapoğlu Kılıç, Beyda Sevgül Aparı, Pelinsu Şahin","doi":"10.1186/s12903-025-05916-4","DOIUrl":"https://doi.org/10.1186/s12903-025-05916-4","url":null,"abstract":"<p><strong>Background: </strong>This study evaluated the presence of preoperative apical periodontitis (AP) in endodontically treated teeth within a Turkish population, along with its causes, treatment methods, and the effectiveness of preventive and early intervention practices.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 1,440 teeth from 1,055 patients treated at Van Yüzüncü Yıl University between 2021 and 2023. Preoperative panoramic and periapical radiographs and postoperative periapical radiographs were examined. Data recorded included patient demographics, treated tooth location, presence of preoperative AP, coronal restorations, reasons for treatment, treatment methods, and number of missing and endodontically treated teeth. Statistical analyses were performed using Chi-Square, Mann-Whitney U, Kruskal-Wallis, and Spearman correlation tests.</p><p><strong>Results: </strong>The overall incidence of AP was reported as 28.7%. It was more frequently observed in the mandible than in the maxilla and in incisors compared to other tooth groups (p < 0.001). Caries was the primary reason for treatment in molars (81.5%), while periodontal disease was more common in incisors (p < 0.001). As age increased, the number of endodontically treated and missing teeth also rose (p = 0.019; p < 0.001). Teeth with crowns had a lower AP rate, while retreatments due to periodontal disease or previous root canal failures showed higher AP rates (p < 0.001).</p><p><strong>Conclusions: </strong>The high AP rate and the predominance of caries and periodontal disease as treatment causes indicate insufficient application of preventive and early treatments. AP prevalence varied by jaw location, tooth group, coronal restoration and treatment method. This study provides epidemiological data on endodontically treated teeth and their association with AP. These findings emphasize the importance of early diagnosis, preventive measures, and effective treatment planning in preserving tooth survival.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"696"},"PeriodicalIF":2.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis of mini-implant assisted micro-osteoperforation for accelerating canine movement in adult orthodontics.","authors":"Xiaoyan Liu, Jinbing Yu, Kang Liu","doi":"10.1186/s12903-025-05751-7","DOIUrl":"https://doi.org/10.1186/s12903-025-05751-7","url":null,"abstract":"<p><strong>Background: </strong>Traditional orthodontic treatment methods are associated with long treatment durations and patient discomfort. The mini-implant assisted micro-osteoperforation (MOP) has shown great potential in clinical practice, but systematic research on this technology remains limited.</p><p><strong>Methods: </strong>A retrospective analysis of 106 adult patients requiring extraction of both maxillary first premolars were conducted, with patients randomly grouped: experimental group (EG, mini-implant assisted MOP) and control group (CG, conventional orthodontic treatment), with 53 cases in each. Tooth movement distances, root resorption amounts, craniofacial relationship measurement angles (SNA, SNB, ANB), maxillary anterior tooth positions and angles (U1-X, U1-Y, U1-SN), maxillary first molar positions and angles (U6-X, U6-Y, U6-X), and soft tissue angles (NLA) were compared.</p><p><strong>Results: </strong>The distance of canine movement in the EG was (1.89±0.28) mm after 1 month of force application, and (3.67±0.54) mm after 2 months of force application. In the CG, the distance of canine movement was (0.96±0.32) mm after 1 month of force application, and (1.88±0.34) mm after 2 months of force application. The EG suggested visibly greater canine movement distances one month and two months after force application as against the CG, with visibly lower U1-X and U1-Y angles, and visibly lower U6-X and U6-Y angles (P<0.05). No visible distinctions were noted in soft tissue angles between the EG and the CG one month and two months after force application (P>0.05).</p><p><strong>Conclusion: </strong>Compared to existing orthodontic treatment methods, implant-supported mini-screw perforation surgery, as an auxiliary approach to accelerate orthodontic treatment, can significantly accelerate tooth movement without significantly increasing the risk of root resorption, and has minimal impact on craniofacial relationships and soft tissues. This finding provides a new and effective adjunct for orthodontic treatment, with the potential to shorten treatment duration and improve the patient experience in clinical practice, making it of significant importance for advancing the development of orthodontic techniques.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"695"},"PeriodicalIF":2.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}