BMC Oral Health最新文献

{"title":"Correction: Effect of head orientation on mandibular bone linear measurements in CBCT imaging.","authors":"Rojin Ardalani, Azadeh Torkzadeh, Roshanak Ghafari, Mohammad Javad Saeedi Borujeni","doi":"10.1186/s12903-025-06409-0","DOIUrl":"10.1186/s12903-025-06409-0","url":null,"abstract":"","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"948"},"PeriodicalIF":2.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Childhood Oral Health Impact Scale (ECOHIS) questionnaire: reliability generalization meta-analysis of Cronbach's alpha.","authors":"Kalyana C Pentapati, Deepika Chenna, Vijay S Kumar, Nanditha Kumar, Mithun Pai, Saurabh Kumar","doi":"10.1186/s12903-025-06342-2","DOIUrl":"10.1186/s12903-025-06342-2","url":null,"abstract":"<p><strong>Objective: </strong>To summarise the estimates of Cronbach's α for the Child Impact Section (CIS), Family Impact Section (FIS), and total Early Childhood Oral Health Impact Scale (ECOHIS) and to identify the significant predictors that may influence the pooled estimates.</p><p><strong>Materials and methods: </strong>A systematic search was conducted in PubMed, Scopus, EMBASE, Web of Sciences, Dentistry and Oral Science Source, and CINAHL from inception until 21st November 2024. Included were those reported in English with Cronbach's α values for the ECOHIS or its subscales. Abstracts, conference proceedings, letters to editors, pilot studies, brief communications, and commentary were omitted. Two review authors independently reviewed the title and abstracts and full-text. Data extraction included demographic characteristics, language, study design and setting, sampling, Cronbach's α, and questionnaire item count. COSMIN checklist was used for quality assessment and \"Reliability Generalization Meta-analysis\" (RGMA) was conducted to estimate the internal consistency of ECOHIS questionnaire.</p><p><strong>Results: </strong>Overall, 1,524 publications were retrieved, of which 454 and 304 were available for screening title and abstracts and full texts respectively. Among the included 66 publications, 74 estimates were obtained. The pooled Cronbach's α for the total scale was 0.86 with high heterogeneity (I² = 95.43). No significant impact of moderators was seen on the pooled estimate. Subgroup analysis showed little variation in the pooled estimates for continent, language, study setting, study design, and type of sampling. Only 46 estimates were included for the RGMA of CIS (0.85) and FIS (0.79). No significant effects of moderators were seen on the pooled Cronbach's α for both CIS and FIS. Similarly, subgroup analysis showed little variation in the pooled estimates for the CIS and FIS for various categorical predictors.</p><p><strong>Conclusion: </strong>The pooled Cronbach's α of ECOHIS and its sub-scales were higher than the acceptable benchmark with no effect of moderators.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"947"},"PeriodicalIF":2.6,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral manifestations in patients with chronic hepatitis C.","authors":"Michał Brzdęk, Joanna Gałuszka-Garnuszek, Krystyna Dobrowolska, Kinga Brzdęk, Jakub Janczura, Olga Tronina, Magdalena Kal, Piotr Stępień, Dorota Zarębska-Michaluk","doi":"10.1186/s12903-025-06307-5","DOIUrl":"10.1186/s12903-025-06307-5","url":null,"abstract":"<p><strong>Background: </strong>Hepatitis C virus (HCV) infection, a systemic disease characterized by extrahepatic manifestations (EMs), affects approximately 50 million people worldwide. Recognizing EMs, which may involve multiple organs and systems, is crucial for timely diagnosis and effective antiviral therapy. Purpose of the study was to investigate extrahepatic symptoms occurring in the oral mucosa in HCV-infected patients.</p><p><strong>Methods: </strong>The observational study included 153 consecutive patients with chronic hepatitis C and healthy controls. Data collection encompassed demographic parameters, medical history, laboratory results, and oral examinations, which included evaluation of dry mouth, pain and burning in the mouth and on the tongue, pain in the angles of the mouth, bad breath, gingival bleeding, dysphagia and taste disorders using scales designed for this purpose, clinical and dental examination.</p><p><strong>Results: </strong>Subjective oral symptoms were twice as common in the study group as in controls with the most frequent dry mouth, followed by oral pain, and burning in the mouth. Pathological changes (oral candidiasis, angular cheilitis and lichen planus), were identified in 73.2% of patients, compared to 32% in the control group. Oral hygiene was worse in the study group with a median score of 1.8 compared to 1.1 as assessed by the Oral Hygiene Index scale. The incidence of Mikulicz's aphthae, papillomas, fibromas and sublingual varices did not reach statistically significant differences. The study group had fewer teeth with dental fillings. Additionally, age ≥ 40 years and GT1 infection were identified as independent predictors of oral pathologies in HCV-infected patients.</p><p><strong>Conclusions: </strong>In patients with chronic HCV infection, oral mucosal pathologies were significantly more common compared to controls, with candidiasis, angular cheilitis, and oral lichen planus being the most frequently observed conditions. Subjective symptoms such as dry mouth, oral pain, and burning were also markedly higher in the HCV group. Age ≥ 40 years and GT1b HCV genotype were identified as independent positive predictors of oral mucosal lesions.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"944"},"PeriodicalIF":2.6,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring schoolchildren's perspectives on oral health in a disadvantaged neighbourhood in The Hague - a participatory action research project.","authors":"Alice E Grasveld, Clarissa Calil Bonifácio, Monique H van der Veen","doi":"10.1186/s12903-025-06347-x","DOIUrl":"10.1186/s12903-025-06347-x","url":null,"abstract":"<p><strong>Background and aim: </strong>Dental caries is the most common childhood disease worldwide, including the Netherlands. Children from low socioeconomic backgrounds and migrant communities are at high risk. This study aimed to explore the perspectives of schoolchildren (9-13 years), from a low socioeconomic neighbourhood in The Hague with a high immigrant population, on oral health, oral health behaviours, oral health professionals and dental care, as well as the root causes and the outcomes of oral health problems. A secondary aim was to co-create suitable oral health interventions with the children.</p><p><strong>Methodology: </strong>The study used a Participatory Action Research (PAR) approach involving 9 focus group discussions (FGDs) with 45 children, semi-structured in-depth interviews with 4 children, 3 informal conversations with adult stakeholders (the school's principal, a teacher, and a women's group 'SW mothers' consisting of 24 women), participant observation in the neighbourhood, and food diaries from 7 children. The research team immersed themselves in the community for 8 months. The study comprised three phases with the children: 1) exploring children's perspectives on oral health, 2) identifying root causes and outcomes of oral health problems constructing a 'problem tree', and 3) co-creating solutions. In phase 4 data were analysed using thematic analysis, and findings were structured according to the Fisher-Owens model, highlighting child-level, family-level, and community-level influences on children's oral health.</p><p><strong>Results: </strong>Children demonstrated oral health knowledge, understanding links between diet, oral health, and social status. They reported conflicting perspectives towards dental professionals, who were seen as kind, but also scary, leading to low dental care utilisation. Poverty in the neighbourhood contributed to 'parentification'. Children were often responsible for their own and their siblings' diet and oral health. Although health initiatives existed, cultural traditions and the local unhealthy food environment influenced dietary habits.</p><p><strong>Conclusion: </strong>While children understood the importance of oral health, socioeconomic and cultural factors hindered their ability to act upon their knowledge. Poverty and the local food environment were identified as key challenges. This PAR project raised awareness, empowering children to drive positive change and share knowledge with their community through a self-made YouTube video and folder on toothbrushing, regular dental visits and healthy eating.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"946"},"PeriodicalIF":2.6,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of silver diamine fluoride and nanosilver on salivary bacterial counts in children with early childhood caries: a randomized controlled clinical trial.","authors":"Nour Ammar, Magda M El-Tekeya, Dalia M Talat, Sara Essa, Marwa M Essawy, Jan Kühnisch, Hams Hamed, Nouran Nabil, Samar El Achy, Maha El Tantawi","doi":"10.1186/s12903-025-06325-3","DOIUrl":"10.1186/s12903-025-06325-3","url":null,"abstract":"<p><strong>Background: </strong>Silver diamine fluoride (SDF) is indicated for the management of early childhood caries (ECC). Similarly, nanosilver fluoride (NSF) is effective against caries. However, there are limited comparisons between both agents, especially regarding their antibacterial effect. This randomized controlled clinical trial aimed to compare the effects of SDF and NSF on salivary bacterial counts in children with ECC.</p><p><strong>Methods: </strong>Fifty 4-6-year-olds presenting with active dentin caries (ICDAS code 5) in primary teeth were randomly allocated to two groups. Streptococcus mutans (S. mutans) and Lactobacilli in unstimulated saliva were cultivated on differential media and counted as colony-forming units. Followed by the application of either 38% SDF or NSF. Saliva samples were recollected after one month. The legal guardians completed a detailed questionnaire assessing their child's dental hygiene habits, dental pain experience, and socioeconomic background. Multivariable binary logistic regression was used to assess the effects of both agents on bacterial counts while accounting for confounders.</p><p><strong>Results: </strong>The mean age of participants was 4.8 ± 0.8 years, with the majority (96%, N = 48) presenting with severe ECC. There were no statistically significant differences between the two groups regarding age, sex, dmft score, socioeconomic background, dental hygiene habits, or dental experience. After one month, within-group analysis showed a significant reduction in S. mutans only in the NSF group (p = 0.002) and significant decreases in Lactobacilli counts in both SDF and NSF groups (p < 0.05). However, between-group comparisons revealed no significant differences in the reduction of S. mutans (1.4% and 6.0%, respectively, p = 0.192) or Lactobacilli counts (6.0% and 6.0%, respectively, p = 0.754). Regression analyses revealed non-significant odds of reduced bacterial counts after NSF application compared to SDF.</p><p><strong>Conclusion: </strong>After one application, children with ECC showed significant decrease in salivary bacteria, with no difference between the two agents regarding their antibacterial effect. NSF can serve as a viable option in ECC management in that it provides comparable antibacterial effects to 38% SDF without inducing tooth discoloration. This trial was prospectively registered on the clinicaltrials.gov registry with ID: NCT05221749 on 03/02/2022.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"945"},"PeriodicalIF":2.6,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of tooth brushing behavior with risks of major chronic health outcomes: a scoping review.","authors":"Hee-Jung Park, Nam-Hee Kim, Sun-Jung Shin, Hwa-Young Lee, Jin-Young Jeong","doi":"10.1186/s12903-025-06332-4","DOIUrl":"10.1186/s12903-025-06332-4","url":null,"abstract":"<p><strong>Background: </strong>Oral hygiene behavior has been increasingly recognized as a potential contributor to chronic disease prevention. This scoping review aimed to synthesize existing evidence on the associations between tooth brushing behavior (as a proxy for oral hygiene) and major chronic health outcomes, including cardiovascular events (e.g., myocardial infarction, atrial fibrillation, heart failure), stroke (ischemic, hemorrhagic, and subarachnoid), hypertension (HTN), metabolic syndrome (MetS), and chronic kidney disease (CKD).</p><p><strong>Methods: </strong>A comprehensive literature search was conducted using four databases: Ovid-MEDLINE, EMBASE, CINAHL, and the Cochrane Library. The study selection process followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. Two reviewers independently screened and selected eligible studies and extracted relevant data. A total of 142 full-text articles were assessed for eligibility.</p><p><strong>Results: </strong>Twenty-one studies were included in the final review. Most studies reported that a lower frequency of tooth brushing was associated with a higher risk of cardiovascular events, stroke, HTN, MetS, and CKD. Additionally, several studies suggested that maintaining good oral hygiene in individuals with HTN or diabetes mellitus (DM) may be associated with a reduced risk of cardiovascular complications.</p><p><strong>Conclusion: </strong>Frequent tooth brushing, as a key component of oral hygiene, may be associated with a reduced risk of several chronic health outcomes, particularly cardiovascular and metabolic diseases. However, the current body of evidence is predominantly based on observational studies. Further longitudinal and interventional research is warranted to clarify the directionality and potential causal pathways linking oral hygiene behavior to systemic health outcomes.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"943"},"PeriodicalIF":2.6,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of surface treatments on the adhesion strengths between polyether ether ketone and both composite resins and poly(methyl methacrylate).","authors":"Yongcheng Ge, Ting Zhao, Sizheng Fan, Pengyuan Liu, Xiaoqiu Liu","doi":"10.1186/s12903-025-06305-7","DOIUrl":"10.1186/s12903-025-06305-7","url":null,"abstract":"<p><strong>Background: </strong>This study evaluated the effects of three surface treatments-concentrated H₂SO₄, sodium borohydride (NaBH₄), and their combination-on the shear bond strengths between polyether ether ketone (PEEK) and both composite resins and poly(methyl methacrylate) (PMMA).</p><p><strong>Methods: </strong>PEEK specimens (n = 160) were randomly assigned to composite resin and PMMA groups, each of which was subdivided into normal and aging groups (n = 40), each comprising samples that were pristine (untreated) or treated with dimethyl sulfoxide (DMSO), NaBH₄, or concentrated H₂SO₄ or sequentially treated with NaBH₄ and concentrated H₂SO₄ (n = 8). The shear bond strength (SBS) of the normal and aged specimens were measured. For the normal and treated specimens, the surface and cross-sectional morphologies were analyzed using scanning electron microscopy (SEM), the chemical bond modifications were investigated using X-ray photoelectron and attenuated total reflectance Fourier-transform infrared spectroscopies (XPS and ATR-FTIR, respectively), the mechanical strengths were measured using three-point bending tests, and the cytotoxicities were evaluated using cell-counting kit-8 (CCK-8) assays and 4',6-diamidino-2-phenylindole (DAPI) staining.</p><p><strong>Results: </strong>NaBH₄ etched the PEEK surface, generating a fibrous texture, while concentrated H₂SO₄ produced a surface possessing variously sized pores. Sequential treatment with NaBH₄ and concentrated H₂SO₄ produced dense, permeating pores. XPS confirmed that NaBH₄ reduced carbonyl groups to hydroxyl groups on the PEEK surface. ATR-FTIR spectroscopy confirmed that the silane coupling agent grafted onto the PEEK surface, forming Si-O-C bonds. NaBH₄ and concentrated H₂SO₄ both strengthened the shear bonding between the PEEK and both the composite resins and PMMA (P < 0.05). The specimens sequentially treated with NaBH₄ and 98% concentrated H₂SO₄ possessed the strongest shear bonding (P < 0.05). The aged specimens sequentially treated with NaBH₄ and concentrated H₂SO₄ retained very strong shear bonds. CCK-8 cytotoxicity assays and DAPI staining confirmed that these surface treatments meet oral biocompatibility standards.</p><p><strong>Conclusion: </strong>NaBH₄ introduced chemical bonds to the PEEK surface, while concentrated-H₂SO₄-induced sulfonation enhanced the micromechanical interlocking between the PEEK and both the composite resins and PMMA. These combined physicochemical modifications significantly strengthened the adhesion between the PEEK and both the composite resins and PMMA and effectively strengthened PEEK's bonding.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"940"},"PeriodicalIF":2.6,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and immunopathological assessment of the oral mucosa in coeliac disease: a pilot study.","authors":"Agnieszka Mania-Końsko, Zuzanna Ślebioda, Aleksandra Dańczak-Pazdrowska, Marzena Liliana Wyganowska","doi":"10.1186/s12903-025-06329-z","DOIUrl":"10.1186/s12903-025-06329-z","url":null,"abstract":"<p><strong>Background: </strong>Coeliac disease (CD) is a lifelong immune-mediated systemic disease that develops in genetically predisposed subjects who show intolerance to gluten proteins. Intestinal wall inflammation with villi atrophy results in malabsorption of nutrients and leads to several gastrointestinal and systemic symptoms. High serum levels of anti-endomysial and anti-tissue transglutaminase autoantibodies can be revealed in patients with CD. The aim of the study was to evaluate the presence of IgA, IgG, IgM, and C3 complement deposits in the oral mucosa and its condition in CD patients.</p><p><strong>Methods: </strong>Thirty CD patients underwent complete clinical examination followed by mycologic evaluation, of whom 10 additionally had oral mucosa biopsy. Direct immunofluorescence (DIF) was performed on the oral mucosa specimens using polyclonal rabbit IgG, IgA, IgM, and C3 antibodies. The results were statistically analyzed.</p><p><strong>Results: </strong>The most common complaints included pain due to oral ulcers, xerostomia, and gingival bleeding. Frequently observed comorbidities were anemia, allergy, and thyroid disorders. Common oral mucosal findings included white-coated tongue, linea alba, and atrophic glossitis. Candidiasis was revealed in 13 subjects (43.3%). IgA, IgG, IgM, or C3 deposits in the oral mucosa specimens were shown in none of the patients.</p><p><strong>Conclusions: </strong>Coeliac disease may increase the frequency of white-coated tongue, linea alba, and atrophic glossitis and may promote the development of oral candidiasis. However, there are no evident markers in the CD patients' immunopathologic examination of the oral mucosa specimens.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"942"},"PeriodicalIF":2.6,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Keratinocyte necroptosis promotes the progression of radiation-induced oral mucositis.","authors":"Manqiong Dai, Xingzhu Dai, Yuee Liang, Xiaoyu Li, Huacong Huang, Wanghong Zhao","doi":"10.1186/s12903-025-06278-7","DOIUrl":"10.1186/s12903-025-06278-7","url":null,"abstract":"<p><strong>Importance: </strong>Radiation-induced oral mucositis (RIOM) is a prevalent complication arising from radiation therapy for tumors or combined radiotherapy, but the therapeutic options available remain limited. Understanding its underlying mechanisms is crucial for developing effective interventions.</p><p><strong>Objectives: </strong>To investigate whether keratinocyte necroptosis contributes to RIOM pathogenesis and evaluate the effects of RIPK3/MLKL inhibition.</p><p><strong>Methods: </strong>A mouse model of RIOM was established with varying irradiation doses. Tongue tissues were analyzed via histological staining, immunohistochemistry, and Western blot. In vitro, keratinocytes were irradiated and treated with RIPK3 or MLKL inhibitors. Subsequently, cell viability, necroptosis, and inflammatory cytokine expression were assessed using CCK-8, LDH release, Western blot, flow cytometry and RT-qPCR.</p><p><strong>Results: </strong>In irradiated mouse tongues, p-RIPK3/RIPK3 and p-MLKL/MLKL ratios were significantly elevated (P < 0.01), accompanied by heightened expression levels of IL-1β and IL-6. Similar findings were observed in keratinocytes, which, after 12 Gy irradiation for 2.5 days, reduced cell viability (P < 0.001), enhanced necroptotic marker expression (P < 0.001), and increased inflammatory cytokine levels (P < 0.001). Furthermore, treatment with RIPK3 inhibitor GSK'872 or MLKL inhibitor GW806742X significantly reduced irradiation-induced keratinocyte cell death (P < 0.001), LDH release (P < 0.001) and the expression of inflammatory cytokines (P < 0.01).</p><p><strong>Conclusions: </strong>This study provides evidence that RIPK3/MLKL-mediated necroptosis in keratinocytes contributes to the pathogenesis of RIOM. Inhibiting this pathway reduces cell death and inflammation, suggesting a promising therapeutic target for the treatment of RIOM.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"941"},"PeriodicalIF":2.6,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of implant survival, peri-implant health, and patient satisfaction among three treatment modalities in atrophic posterior mandibles: a randomized clinical study.","authors":"Eman Mohamed Raffat, Mohamed Shady, Ayman Abdel Rahim Elkashty, Moustafa El Syad","doi":"10.1186/s12903-025-06286-7","DOIUrl":"10.1186/s12903-025-06286-7","url":null,"abstract":"<p><strong>Background: </strong>This study assessed the clinical outcomes of fixed and removable implant-assisted prostheses for the rehabilitation of atrophied distal extension mandibular ridges.</p><p><strong>Methods: </strong>Thirty partially edentulous patients with atrophied distal extension mandibular ridges were randomized to three groups (n = 10/group). Group ALF received long implants following alveolar ridge augmentation to support fixed restorations. Group SF received short implants to support fixed restorations. Group OVD received two long implants to support a removable partial denture. The plaque index (MPI), gingival index (MGI), Pocket depth (PD), implant stability (IS), and crestal bone loss (CBL) were assessed: immediately after the prosthesis insertion (T0), six months (T6), and twelve months (T12) later. All groups were assessed for patient satisfaction after 12 months using a visual analogue scale (VAS) survey.</p><p><strong>Results: </strong>Implant survival rates were 89.7%, 91.7%, and 85% in the ALF, SF, and OVD groups (Chi-square = 0.972, log-rank test, p =.673). The ALF and SF groups had significantly greater plaque and gingival scores (P <.05) than the OVD group At T6 and T12. The ALF group exhibited significantly higher PD and IS values (P ˂ 0.05) compared to the OVD group At T6 and T12. The OVD group had the greatest significant CBL values (P <.05) at T6 and T12, whereas the SF group presented the lowest significant values. The ALF and SF groups showed the highest significant satisfaction levels (P <.05) regarding appearance, esthetics, retention, stability, chewing, bolus quality, and occlusion. On the other hand, the OVD group expressed the highest significant satisfaction (P <.05) with surgery, healing, and cleaning.</p><p><strong>Conclusions: </strong>Fixed restorations supported by either short implants or long implants inserted in augmented bone are equally successful in the rehabilitation of the atrophic posterior mandible, with improved patient satisfaction than implant-assisted partial dentures. Nevertheless, the SF group had favorable peri-implant soft tissue health and decreased marginal bone loss compared to the ALF group. Conversely, implant-assisted partial overdentures demonstrated favorable peri-implant soft tissue health and increased patient satisfaction regarding surgery and healing compared to fixed restoration.</p><p><strong>Trial registration: </strong>Current Trial NCT05978115 (28/07/2023) \"Retrospectively registered\".</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"939"},"PeriodicalIF":2.6,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}