BMC Oral Health最新文献

{"title":"Early postoperative evaluation of an open-source digital workflow for designing custom-made zirconia membranes in maxillary guided bone regeneration.","authors":"Muhammad Ibrahim Sakr, Ahmed Sobhy Salem, Ayman Ahmed Yaseen, Mohamed Abdel-Monem Tawfik, Noha Ahmed Mansour","doi":"10.1186/s12903-025-06592-0","DOIUrl":"10.1186/s12903-025-06592-0","url":null,"abstract":"<p><strong>Background: </strong>Computer-guided surgery has played a crucial role in planning alveolar ridge augmentation. In the last decade, various software programs have been used in computer-guided fabricated nonresorbable membranes, including zirconia membranes, for guided bone regeneration. However, most of these software programs are not free of charge.</p><p><strong>Objectives: </strong>This study aimed to evaluate clinically and radiographically the accuracy of an open-source digital workflow for designing custom-made zirconia membranes for maxillary guided bone regeneration.</p><p><strong>Materials and methods: </strong>Twelve custom-made zirconia membranes were designed for 12 patients with maxillary alveolar defects via the integration of two free open-source software programs (Blue Sky Plan^® and Autodesk Meshmixer^®) via a preoperative cone beam computed tomography scan. All patients underwent maxillary alveolar bone augmentation via the designed membranes and particulate mixtures of 1:1 autogenous and xenogenic bone grafts. The membranes were evaluated intraoperatively and radiographically via an immediate postoperative cone beam computed tomography scan, and the collected data were statistically analysed.</p><p><strong>Results: </strong>All the membranes had accurate intraoperative fits, and there were no significant differences between the virtual and milled (actual) membranes in either the volumetric analysis or the linear horizontal and vertical measurements; the P values were (0.628, 0.226 and 0.239), respectively. The designing time was significantly reduced from 4 h for the first case to 22 min for the final case, while the (mean ± standard deviation) milling time was 28 min ± 11 min, and the (mean ± standard deviation) time of the whole digital workflow including membrane sterilization was 5 h and 20 min ± 1 h and 15 min.</p><p><strong>Conclusion: </strong>Zirconia membranes can be designed with free open-source software with outstanding clinical fit and promising radiographic results. Further research should be performed with larger sample sizes and other rigid Guided Bone Regeneration membrane materials.</p><p><strong>Trial registration number: </strong>NCT06227455.</p><p><strong>Trial first posted date: </strong>26/1/2024 (Retrospectively registered).</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1200"},"PeriodicalIF":2.6,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12275381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental perceptions of ultrasonography in pediatric dental diagnostics: a cross-sectional study.","authors":"Burcin Avci, Sema Kaya","doi":"10.1186/s12903-025-06548-4","DOIUrl":"10.1186/s12903-025-06548-4","url":null,"abstract":"<p><strong>Background: </strong>The use of ultrasonography in pediatric dentistry has gained attention due to its safety, diagnostic versatility, and ability to minimize radiation exposure in children. This study aimed to evaluate parents' knowledge, attitudes, and perceptions regarding the use of ultrasonographic imaging in pediatric dentistry.</p><p><strong>Methods: </strong>This cross-sectional study included the parents of 347 children aged 1 to 13 years who attended the pediatric dentistry clinic of a public dental school in Van, eastern Turkey. Data were collected through face-to-face interviews using a 27-item questionnaire covering parents' demographic characteristics, knowledge, attitudes, and concerns about ultrasonography. Chi-square and correlation analyses were used to evaluate the relationships between variables.</p><p><strong>Results: </strong>Parents' knowledge and attitudes varied significantly by educational level and gender. Those with higher education levels demonstrated greater awareness and positive attitudes toward ultrasonography in dentistry. Female parents showed a greater preference than male parents for using ultrasonography in their children's dental treatment. Correlation analyses revealed strong positive associations among knowledge, attitudes, perceived benefits, and health literacy scores (r = 0.764-0.923, p < 0.001).</p><p><strong>Conclusions: </strong>Although parents generally held positive attitudes toward ultrasonography in pediatric dentistry, their level of knowledge was limited. Educational level and gender significantly influenced parental knowledge and health literacy. These findings highlight the need for targeted educational interventions to support informed participation in dental diagnostics.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1191"},"PeriodicalIF":2.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of periodontitis by three different approaches to non-surgical periodontal debridement- a randomized comparative clinical study.","authors":"Kodikara Mudiyanselage Chathurika Padmakumari, Uthpala Muhandiramge Gunasekara, Ranjith Pallegama, Aruni Tilakaratne","doi":"10.1186/s12903-025-06595-x","DOIUrl":"10.1186/s12903-025-06595-x","url":null,"abstract":"<p><strong>Background: </strong>Non-surgical periodontal therapy (NSPT) is the cornerstone of periodontitis management. This comparative clinical study evaluates the effectiveness of three different non-surgical treatment approaches in three treatment groups, namely, Quadrant-wise Scaling and Root Surface Debridement (Q-Sc + RSD), Full-mouth Disinfection (FMDis), and Full-mouth Debridement (FMDeb).</p><p><strong>Methods: </strong>A total of 45 patients with generalised stage II and III periodontitis were randomly assigned to one of the three treatment groups. Plaque scores (PS), bleeding scores (BS) and probing pocket depths (PD) were recorded at baseline and post-NSPT. Data were analyzed to compare the changes in PS, BS, and PD distribution at baseline and post-NSPT in all three groups.</p><p><strong>Results: </strong>All three treatment approaches resulted in statistically significant reductions in PS, BS, and PD distribution compared to baseline. However, FMDeb and FMDis protocols demonstrated greater reductions in BS and PD distribution compared to the Q-Sc + RSD protocol. Remarkably low BS were observed in all three study groups at the post-treatment evaluation, with statistically significant differences compared to their respective pre-treatment BS.</p><p><strong>Conclusions: </strong>All three treatment approaches were effective in reducing PS, BS, and PD in patients with periodontitis, while FMDeb and FMDis protocols demonstrated superior effectiveness in terms of reduction of BS and PD, compared to the Q-Sc + RSD protocol. Further research with larger sample sizes and longer follow-up periods may be warranted to confirm these findings and evaluate the long-term clinical outcomes of these different debridement approaches of NSPT.</p><p><strong>Clinical trial no: </strong>The UK's Clinical Study Registry ISRCTN13350022, 28/05/2025, retrospectively registered.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1185"},"PeriodicalIF":2.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between latent categories of body image and sleep quality in adolescent orthodontic patients.","authors":"Chen Xu, Ying Zhang, Bin Xiong, Hualun Wang, Mengyao Liang","doi":"10.1186/s12903-025-06571-5","DOIUrl":"10.1186/s12903-025-06571-5","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to identify potential categories of negative body image among adolescent orthodontic patients and further examine the relationship between these categories and sleep quality.To provide evidence for clinical psychological intervention.</p><p><strong>Methods: </strong>A total of 322 adolescent orthodontic patients were randomly selected from six stomatological hospitals in Jiangsu and Zhejiang provinces, China, between June 2024 and February 2025. A field survey was conducted using a general information questionnaire, the Sociocultural Attitudes Towards Appearance Questionnaire-4 (SATAQ-4R), the Pittsburgh Sleep Quality Index (PSQI), and the Body Image Scale (BISS). Data were analyzed using latent profile analysis, χ² tests, and logistic regression.</p><p><strong>Results: </strong>Of the 322 surveys distributed, 311 valid responses were collected, yielding an effective response rate of 96.58%. The average body image score was 29.36 ± 6.13. Latent profile analysis identified three categories of body image: self-acceptance (11.90%, 37 cases), self-negative (60.77%, 189 cases), and self-critical (27.33%, 85 cases). χ² tests revealed significant differences related to gender, being an only child, education level, BMI, and SATAQ-4R scores (P < 0.05). Logistic regression analysis indicated that female gender, self-negative, and self-critical body image types were significant risk factors for poor sleep quality in this population (P < 0.05).</p><p><strong>Conclusions: </strong>Adolescent orthodontic patients exhibit heterogeneous body image perceptions, with negative body image serving as a risk factor for poor sleep quality. Clinical attention should be paid to female and adolescent orthodontic patients with higher appearance anxiety or peer pressure. Early psychological assessment and combined orthodontic-psychological intervention should be used to help improve their body image cognition and sleep quality.​.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1190"},"PeriodicalIF":2.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ensemble learning for microbiome-based caries diagnosis: multi-group modeling and biological interpretation from salivary and plaque metagenomic data.","authors":"Fangqiao Wei, Zailong Wu, Guanghui Li, Xiangyu Sun, Xiangru Shi, Lei Tan, Tianxiang Ai, Long Qu, Shuguo Zheng","doi":"10.1186/s12903-025-06590-2","DOIUrl":"10.1186/s12903-025-06590-2","url":null,"abstract":"<p><strong>Background: </strong>Oral microbiota is a major etiological factor in the development of dental caries. Next-generation sequencing techniques have been widely used, generating vast amounts of data which is underexplored. The advancement of artificial intelligence (AI) technologies has made it possible to mine information from these large datasets. This study aimed to develop AI-driven diagnostic models and identify key microbial features for caries.</p><p><strong>Methods: </strong>We collected raw metagenomic and full-length 16 S rRNA gene sequencing data from previous studies on saliva and plaque to construct a caries AI training dataset comprising nearly 600 samples. Samples were grouped based on age, sequencing and sampling method. Through systematic comparison of seven machine learning architectures, including Logistic Regression, Random Forest, Support Vector Machines, Gradient Boosting, Convolutional Neural Networks, Feedforward Neural Networks, and Transformer models, we developed subgroup-specific caries diagnostic models, with subsequent ensemble learning integration to enhance generalizability.</p><p><strong>Results: </strong>The caries diagnostic model achieved a maximum AUC value of 1 (accuracy of 100%) for children under 6 years old in both saliva and plaque groups. The consistency of top features (species and metabolic pathways) contributing to the models was demonstrated through intra- and inter-group analyses. Key caries-associated species included Streptococcus salivarius, Streptococcus parasanguinis and Veillonella dispar. Veillonella parvula exhibits higher abundance in caries plaque samples, while being elevated in healthy saliva samples. Metabolic pathways like geranylgeranyl diphosphate and fructan biosynthesis were enriched in caries, whereas Bifidobacterium shunt and peptidoglycan biosynthesis were depleted.</p><p><strong>Conclusion: </strong>The current work provided reliable diagnostic models for early childhood caries, and established a robust computational framework for AI-driven microbiome analysis. This study, by focusing on the characteristics of the oral microbiome, offers novel perspectives for data mining and validation of existing data through the application of AI modelling.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1188"},"PeriodicalIF":2.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12272970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bond strength durability of three bioactive restorative materials to silver diamine fluoride treated artificially demineralized dentine.","authors":"Mostafa A Abdelshafi, Hanan A N Soliman, Dina Abdelaziz","doi":"10.1186/s12903-025-06552-8","DOIUrl":"10.1186/s12903-025-06552-8","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to assess the impact of 38% silver diamine fluoride (SDF) treatment regarding microtensile bond strength of three bioactive restorative materials to artificially induced caries-affected dentine after thermocycling; Alkasite restorative material, Glass hybrid restorative (GHR) and Resin modified glass ionomer (RMGI).</p><p><strong>Methods: </strong>A total of 60 artificially demineralized human mid-coronal dentine specimens were randomly allocated into two main groups (n = 30 each): a control group and an SDF-treated group (38% SDF). Each group was additionally split into three subgroups (n = 10) regarding the type of restorative material (Alkasite; Cention N, GHR; EQUIA Forte fil, RMGIC; Fuji II LC). 10,000 cycles of thermal cycling were conducted alternating between 5 ºC - 55 ºC with a dwell-duration of 15 s. µTBS was assessed with the aid of a universal testing machine (Instron Co., Canton, MA-USA) occupied with a 50 kg load cell, operating at 0.5 mm/min cross-head speed till failure. µTBS results, measured in MPa, were collected and statistically analyzed with two- and one-way ANOVA succeeded by Tukey's post hoc test and student's t-test (α = 0.05).</p><p><strong>Results: </strong>There was a significant reduction in µTBS after SDF application in all tested groups (p ≤ 0.05). Cention N recorded the highest bond strength values in both control and SDF-treated conditions, while EQUIA Forte Fil had the lowest.</p><p><strong>Conclusions: </strong>Based on the limitations of this laboratory study, the application of 38% SDF directly preceding restoration with Alkasite, GHR or RMGI resulted in a significant deterioration in bond strength to artificially induced caries-affected dentine.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1193"},"PeriodicalIF":2.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of MMP-8, MMP-20, and TGF-β1 in molar-incisor hypomineralization and assessment of periodontal health.","authors":"Başak Senian Bilgir, Sema Aydınoğlu, İpek Arslan, Mehtap Atak, Oğuz Köse, Dilara Nil Günaçar","doi":"10.1186/s12903-025-06551-9","DOIUrl":"10.1186/s12903-025-06551-9","url":null,"abstract":"<p><strong>Background: </strong>Gingival crevicular fluid (GCF) volume can be used to evaluate periodontal diseases, along with matrix metalloproteinase-8 (MMP-8) and transforming growth factor-beta 1 (TGF-β1) found in GCF. Conversely, matrix metalloproteinase-20 (MMP-20) is implicated in amelogenesis and serves as a potential biomarker for assessing enamel mineralization. In this context, the present study aims to investigate the effect of molar incisor hypomineralization (MIH) on periodontal health and to evaluate the relationship between MIH and GCF volume, as well as GCF biomarkers such as MMP-8, MMP-20, and TGF-β1.</p><p><strong>Methods: </strong>The study was conducted on a total of 40 pediatric patients diagnosed with MIH (Study Group/SG), and 40 pediatric patients healthy for MIH (Control Group/CG). Clinical periodontal measurements (plaque index (PI), gingival index (GI), probing pocket depth (PPD), and GCF volume were performed. Concentrations of MMP-8, MMP-20, and TGF-β1 in GCF were determined using the enzyme-linked immunosorbent assay (ELISA). Mann-Whitney U test and T-test were used for statistical comparisons between groups. Binary Logistic Regression Analysis was performed for independent risk factors affecting MIH status. Finally, the ROC curve was used to determine the optimal cut-off value for MMP-20.</p><p><strong>Results: </strong>PI, GI, PPD, and GCF volume values were significantly higher in the SG than in CG (p < 0.001, p = 0.007, p = 0.001, p = 0.007, respectively). According to binary logistic regression analysis, a one-unit decrease in MMP-20 level increased the risk of MIH four-fold (p < 0.001). However, no significant differences between the groups in terms of MMP-8 and TGF-β1 were observed (p = 0.564, p = 0.088, respectively). Finally, a significant area under the curve (AUC) value was found in determining MIH status for the MMP-20 variable (AUC = 0.948; p < 0.001).</p><p><strong>Conclusions: </strong>Along with the increased tendency for gingivitis in MIH, detecting low concentrations of MMP-20, one of the biomarkers known to be effective in enamel mineralization, in the GCF of patients with MIH is the first information to record in the dental literature.</p><p><strong>Trial registration: </strong>The trial protocol was retrospectively registered under ID NCT06764043 ( https://clinicaltrials.gov/ ); Jan 7, 2025.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1189"},"PeriodicalIF":2.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the current status and influencing factors of oral health-related quality of life in orthodontic patients with fixed appliances from the perspective of self-efficacy.","authors":"Wanying Su, Xiaowen Feng, Cuiyin Peng, Fang Shen, Yanyan Wu, Yun Rao, Anqi Cai, Wei Xiao","doi":"10.1186/s12903-025-06466-5","DOIUrl":"10.1186/s12903-025-06466-5","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the association between self-efficacy and oral health-related quality of life (OHRQoL) in orthodontic patients with fixed appliances, and to identify relevant demographic, behavioral, and psychological factors.</p><p><strong>Methods: </strong>A convenience sampling method was employed to recruit 200 patients attending follow-up visits in the orthodontics department of a tertiary dental hospital in Guangzhou. Data were collected using a demographic questionnaire, the Oral Health Impact Profile (OHIP-14), the Oral Management Self-Efficacy Scale (OMSES), and the Modified Dental Anxiety Scale (MDAS). Pearson correlation analysis was used to examine the associations among oral health-related quality of life, orthodontic self-efficacy, and dental anxiety in patients with fixed appliances. Multiple linear regression analysis was conducted to explore the factors associated with oral health-related quality of life in this patient population. A total of 223 questionnaires were distributed, and 200 valid responses were obtained, resulting in an effective response rate of 89.69%.</p><p><strong>Results: </strong>The mean OHIP-14 score among patients with fixed appliances was 17.83 ± 8.10, with the highest subscale score observed in the domain of psychological discomfort (1.71 ± 0.87). The mean self-efficacy score was 125.40 ± 9.93. Pearson correlation analysis revealed a significant negative correlation between self-efficacy and OHRQoL (r = - 0.221, P < 0.01), and a significant positive correlation between dental anxiety and OHRQoL (r = 0.338, P < 0.001). Multiple linear regression analysis further confirmed that self-efficacy (β = - 1.165, P < 0.05) and dental anxiety (β = 0.335, P < 0.001) were both significant predictors of OHRQoL.</p><p><strong>Conclusion: </strong>The oral health-related quality of life among patients with fixed appliances was moderate, suggesting that further improvement is achievable. Healthcare providers should consider implementing self-efficacy-focused interventions to improve oral health outcomes and enhance quality of life throughout orthodontic care.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1194"},"PeriodicalIF":2.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring ChatGPT's potential in diagnosing oral and maxillofacial pathologies: a study of 123 challenging cases.","authors":"Melek Tassoker","doi":"10.1186/s12903-025-06444-x","DOIUrl":"10.1186/s12903-025-06444-x","url":null,"abstract":"","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1187"},"PeriodicalIF":2.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12272973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silver diamine fluoride: the science behind the action - a narrative review.","authors":"Doaa Jamal, Abdullah AlMushayt, Turki Abujamel, Shatha Bamashmous, Nada Bamashmous, Najlaa Alamoudi","doi":"10.1186/s12903-025-06107-x","DOIUrl":"10.1186/s12903-025-06107-x","url":null,"abstract":"<p><strong>Background: </strong>Silver Diamine Fluoride (SDF) is a caries-arresting agent that gained popularity among clinicians and patients due to its effectiveness within hours of application. However, the exact mechanisms underlying its action are not yet fully understood. This narrative review explores the current knowledge of SDF's role in caries management, focusing on its mechanism of action, application methods, and safety.</p><p><strong>Methods: </strong>A comprehensive search was conducted in PubMed, MEDLINE, ScienceDirect, and Google Scholar. Out of 820 identified studies, 40 were selected based on relevance to SDF's chemical properties and clinical application, following duplicate removal and screening of abstracts and full texts.</p><p><strong>Results: </strong>Although the literature provides insight into SDF's benefits in managing caries, its exact mechanism of action and long-term outcomes remain insufficiently understood. Furthermore, variations in the composition of commercially available SDF products, particularly in silver, fluoride, and pH levels, may significantly affect their clinical performance. This variability raises concerns about consistency in therapeutic outcomes and underscores the need for formulation standardization.</p><p><strong>Conclusion: </strong>Understanding SDF antimicrobial and remineralization mechanisms is essential for optimizing its clinical use in caries management. While current evidence supports its efficacy, further studies are needed to standardize formulations, refine application protocols, and clarify its long-term therapeutic outcomes.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1195"},"PeriodicalIF":2.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}