BMC Oral Health最新文献

{"title":"Impact of treatment modalities on stress distribution in maxillary incisors with varying levels of external cervical resorption: a finite element analysis.","authors":"Ayca Yilmaz, Alper Kabakci, Dilek Helvacioglu Yigit","doi":"10.1186/s12903-025-06562-6","DOIUrl":"10.1186/s12903-025-06562-6","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to evaluate the impact of various treatment modalities on the mechanical behaviour of a simulated maxillary central incisor with external cervical resorption (ECR) at different progression levels using finite element analysis (FEA).</p><p><strong>Methods: </strong>A three-dimensional (3D) model of a maxillary central incisor and surrounding tissues was created. The model was modified to include vestibular or palatal ECR defects of varying heights and circumferential angles. The root canal and the resorption defect were restored using gutta-percha and various repair materials. The models underwent simulated oblique loading of 100 N on the palatal surface. Von Mises stresses within the dentin were evaluated through FEA.</p><p><strong>Results: </strong>The mean maximum stress for models with vestibular ECR defects was greater than that for palatinal defects. Complete filling of both the root canal and defect with BioAggregate resulted in the lowest average dentin stresses (5.79 ± 0.11 MPa), while filling the root canal with gutta-percha and the ECR cavity with glass ionomer cement resulted in the highest (6.19 ± 0.05 MPa).</p><p><strong>Conclusions: </strong>From a mechanical standpoint, filling the root canal with gutta-percha and repairing the resorption defect with Biodentine is the appropriate management option when ECR occurs on the vestibular surface.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1544"},"PeriodicalIF":3.1,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated bioinformatics analysis identifies glutathione metabolism-related genes as diagnostic biomarkers for periodontitis.","authors":"Leilei Meng, Haoshu Fang, Wenjie Wen","doi":"10.1186/s12903-025-06858-7","DOIUrl":"10.1186/s12903-025-06858-7","url":null,"abstract":"<p><strong>Background: </strong>Periodontitis affects over 1 billion people globally, with oxidative stress and glutathione depletion playing crucial roles in disease progression. This study aimed to identify glutathione metabolism-related genes as diagnostic biomarkers for periodontitis using integrated bioinformatics approaches.</p><p><strong>Methods: </strong>Weighted Gene Co-expression Network Analysis (WGCNA) was performed on independent datasets. Key genes were identified in combination with GSE16134 dataset differential expression analysis, which were then validated in the GSE10334 dataset. Immune infiltration analysis using CIBERSORT algorithm, consensus clustering for molecular subtyping, and competing endogenous RNA (ceRNA) network construction were conducted to explore regulatory mechanisms. Drug-gene interaction analysis and molecular docking studies identified potential therapeutic compounds. Experimental validation was performed using ligature-induced periodontitis in rats.</p><p><strong>Results: </strong>Three key glutathione metabolism-related genes were identified: GSTA4 and GGT6 (downregulated) and SLC7A11 (upregulated) in periodontitis patients. The diagnostic model achieved superior performance with AUC values exceeding 0.8. Two distinct molecular subtypes were identified based on immune infiltration patterns. ceRNA regulatory network analysis revealed complex interactions involving all three genes. Drug-gene interaction analysis revealed erastin as a potential therapeutic compound targeting SLC7A11. Experimental validation in rat periodontitis confirmed the upregulation of SLC7A11 in periodontal tissues.</p><p><strong>Conclusions: </strong>Our study identifies SLC7A11, GSTA4, and GGT6 as robust periodontitis biomarkers with excellent diagnostic accuracy. The continuous up-regulation and experimental verification of SLC7A11 genes have established them as promising therapeutic targets, laying the foundation for precision medicine in the field of periodontal therapy.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1546"},"PeriodicalIF":3.1,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CBCT: knowledge, attitude, and practice among dentists.","authors":"Matvey Uvarichev, Valeria Sherstneva, Anna Mikheikina, Maria Polyakova, Alexandr Zaytsev, Vladlena Doroshina, Inna Sokhova, Ksenia Babina, Nina Novozhilova","doi":"10.1186/s12903-025-06870-x","DOIUrl":"10.1186/s12903-025-06870-x","url":null,"abstract":"","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1540"},"PeriodicalIF":3.1,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cone-beam computed tomography evaluation of root and canal morphology of maxillary molars in a Chinese kazakh population.","authors":"Shuchun Yang, Chenye Li, Hui Shi, Ming Liu, Xu Wang","doi":"10.1186/s12903-025-06949-5","DOIUrl":"10.1186/s12903-025-06949-5","url":null,"abstract":"<p><strong>Background: </strong>Maxillary molars have a wide range of anatomical variations. The presence of atypical root canal structures, such as the second mesiobuccal (MB2) canal, complicates endodontic procedures. The purpose of this study was to analyze the differences in root and canal morphology of the maxillary first and second molars in a Chinese Kazakh population by using cone-beam computed tomography (CBCT).</p><p><strong>Methods: </strong>The study included 407 patients, examining maxillary first molars (n = 669) and maxillary second molars (n = 693). The number of roots and canals was recorded, and canal configurations were classified using Vertucci's system. The images were independently assessed by two endodontists, with any discrepancies resolved by a professional oral radiologist to achieve consensus. A chi-square test was used to assess the association between MB2 morphologies and demographic variables, including sex, age, and tooth position.</p><p><strong>Results: </strong>Maxillary first and second molars typically exhibited three roots, with MB2 present in 56.0% and 24.3% of cases, respectively. The predominant MB2 canal type was Vertucci type IV, observed in 71.7% and 60.5% of cases, respectively. Among maxillary first molars, age (p = 0.001) and gender (p = 0.038) showed significant differences, while tooth position (p = 0.104) did not. Among maxillary second molars, age (p = 0.822), gender (p = 0.073), and tooth position (p = 0.392) did not show significant differences.</p><p><strong>Conclusions: </strong>This study was the first to examine the occurrence of the MB2 canal in a Chinese Kazakh group. Under the limitations of the study, maxillary first molars showed a higher occurrence of MB2 than maxillary second molars.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1538"},"PeriodicalIF":3.1,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary chromogranin A levels in periodontal health status: a cross-sectional study evaluating clinical and psychological associations.","authors":"Fatma Soysal, Sila Cagri Isler, Zeliha Guney, Gulcin Akca, Berrin Unsal","doi":"10.1186/s12903-025-06912-4","DOIUrl":"10.1186/s12903-025-06912-4","url":null,"abstract":"<p><strong>Backgrounds: </strong>Psychological stress plays a role in the development of periodontal disease by influencing immune function and behavioral responses. Chromogranin A (CgA), a glycoprotein released due to activation of the sympathetic-adrenomedullary system, shows potential as a salivary biomarker for stress-related immune changes. This study aimed to assess salivary CgA levels in individuals with healthy and diseased periodontal conditions while investigating its correlation with clinical periodontal parameters and psychological stress.</p><p><strong>Methods: </strong>This cross-sectional study involved 56 systemically healthy participants classified into groups based on their periodontal condition: periodontal health, gingivitis, Stage II, and Stage III periodontitis. Clinical periodontal parameters were assessed. Psychological stress levels were measured using the Beck Depression Inventory (BDI). Unstimulated saliva samples were collected and analyzed for CgA mRNA expression. Statistical analyses comprised ANOVA, Spearman's correlation, and chi-square tests.</p><p><strong>Results: </strong>Salivary CgA levels were significantly higher in individuals with Stage III periodontitis compared to those with periodontal health, gingivitis, or Stage II periodontitis (p < 0.01). No significant correlation was observed between salivary CgA levels and BDI scores.</p><p><strong>Discussion: </strong>Although salivary CgA levels were significantly elevated in patients with advanced periodontal disease, no direct associations were observed between CgA levels and individual clinical or psychological stress measures. These findings suggest that CgA may reflect systemic stress-related changes associated with disease severity rather than individual psychological status.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1536"},"PeriodicalIF":3.1,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High degree of dental neglect characterizes adult patients hospitalized with severe odontogenic infections: a retrospective cross-sectional study.","authors":"Sofie Holmboe Dahl, Rasmus Søndenbroe, Simon Storgård Jensen, Esben Boeskov Øzhayat, Merete Markvart","doi":"10.1186/s12903-025-06711-x","DOIUrl":"10.1186/s12903-025-06711-x","url":null,"abstract":"<p><strong>Background: </strong>Dental neglect is associated with deteriorated oral health, which can lead to the development of severe odontogenic infections (SOI) eventually requiring hospitalization. The clinical impact of risk factors for dental neglect remains unknown. This study aims to identify signs of dental neglect in patients hospitalized with odontogenic infections with the overall goal of early detection and prevention.</p><p><strong>Methods: </strong>This study is a retrospective cross-sectional analysis of 384 patients previously hospitalized with a SOI. Patients completing the Dental Neglect Scale (DNS) were included. The patients were divided into two groups based on high and low DNS scores, and were compared in terms of clinical, paraclinical, radiographic, and sociodemographic variables using unadjusted and adjusted estimates (chi-square test of independence, independent sample t-test, and binary logistic regression models).</p><p><strong>Results: </strong>A total of 163 patients completed the DNS (response rate 51.7%), of whom 78 patients (47.8%) had a high DNS score. A high DNS score was significantly related to male sex (p ≤ 0.001), to the indication for having teeth extracted during hospitalization (p = 0.007), and having two or more decayed teeth or teeth with apical periodontitis, with an odds ratio of 3.2 (p = 0.025) and 2.9 (p = 0.019), respectively. The score of Decayed, Missing, and Filled Teeth (DMFT) (p = 0.982) and attendance of dental care prior to hospitalization (p = 0.107) was not correlated with the DNS score.</p><p><strong>Conclusions: </strong>Approximately half of all patients hospitalized with SOI have a high degree of dental neglect. From a clinical perspective, the study addresses the potential of using the clinical threshold or the DNS in the early identification of patients at risk of SOI. However, further research on the topic is necessary to define the target of preventing patients at risk of SOI within the healthcare system. Exploring dental neglect in a non-selected study population might elucidate the validity and clinical usability of the threshold.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1545"},"PeriodicalIF":3.1,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of new Barcelona line and traditional method for 3D planning of orthognathic surgery.","authors":"Berat Serdar Akdeniz, Ezgi Ergezen Arık, Seda Öz, Nur Altıparmak, Sıdıka Sinem Akdeniz","doi":"10.1186/s12903-025-06872-9","DOIUrl":"10.1186/s12903-025-06872-9","url":null,"abstract":"<p><strong>Background: </strong>This retrospective study aims to compare the postoperative facial profiles of Class III orthognathic surgery patients planned according to the true vertical line (TVL) by comparing their positions with the Barcelona line (BL) reference specifically focusing on Class III patients with maxillary retrognathism and mandibular prognathism.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 43 skeletal Class III patients undergoing isolated maxillary LeFort I or bimaxillary surgery. Digital planning data were used for preoperative and postoperative (6 months) upper incisor (UI)-BL measurements. Patients were categorized into four groups based on the maxillary incisor position relative to BL: Group 1 (UI > 4 mm behind BL), Group 2 (UI 0-4 mm behind BL), Group 3 (UI 0-4 mm ahead of BL), and Group 4 (UI > 4 mm ahead of BL).</p><p><strong>Results: </strong>In total of 43 patients, those with maxillary retrognathia showed significant postoperative transitions towards a more protrusive position, while those with mandibular prognathism exhibited greater stability. (p = 0.001) CONCLUSION: BL is a reliable reference in digital planning for skeletal Class III patients, particularly in cases of maxillary retrusion, leading to outcomes more aligned with contemporary aesthetic standards. These findings support incorporating BL into orthognathic surgery planning to optimize sagittal positioning and facial harmony.</p><p><strong>Trial registration: </strong>Baskent University Institutional Review Board approved this study (D-KA24/16). All participants provided informed consent prior to inclusion.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1537"},"PeriodicalIF":3.1,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between oral habits and specific malocclusion traits in children: a retrospective cross-sectional study in Italy.","authors":"Marco Severino, Antonella Mattei, Filippo Vena, Arianna Viarchi, Claudia Theodora Truppa, Guido Lombardo, Riccardo Carullo, Debora Cialfi, Lisa Bertini, Stefano Cianetti","doi":"10.1186/s12903-025-06892-5","DOIUrl":"10.1186/s12903-025-06892-5","url":null,"abstract":"","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1534"},"PeriodicalIF":3.1,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12498458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of dental caries among inmates in the Eastern Province of Saudi Arabia: A cross-sectional study.","authors":"Suliman Shahin, Balgis Osman Gaffar, Muhammad Ashraf Nazir, Ibrahim AlHussain, Wazeer Alghamdi, Jehan Alhumaid","doi":"10.1186/s12903-025-06884-5","DOIUrl":"10.1186/s12903-025-06884-5","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Oral health is a neglected aspect of healthcare, especially among prison inmates who face barriers in accessing dental services. Dental caries is a prevalent and preventable disease that affects inmates' general health and quality of life. This study evaluated dental caries and its predictors among inmates in the Eastern Province of Saudi Arabia.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This cross-sectional study was conducted as part of an ongoing oral health program by the College of Dentistry, Imam Abdulrahman Bin Faisal University(IAU), Dammam, targeting inmates in prisons across Dammam, Khobar, Dhahran, Jubail, and AlHasa in the Eastern Province of Saudi Arabia. This prison outreach program is conducted annually from January to April. Male and female inmates who voluntarily consented were included without exclusion criteria. Data collection involved oral examinations using the DMFT index and Simplified Oral Hygiene Index (OHI-S), following World Health Organization's (WHO) criteria, and structured interviews based on the WHO Oral Health Questionnaire for Adults. Calibrated examiners performed the examinations using portable dental units. Statistical analysis included t-tests, ANOVA, Pearson correlation, and multiple linear regression analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The sample consisted of 230 participants with 86.1% males and 13.9% females. In the study, 98.3% of the sample had untreated decay and 99.1% of participants had DMFT score ranging from 1 to 28, with a mean score of 14.41 ± 7.89. About 25.2% of participants never cleaned their teeth using any tool, 23.5% did not use toothpaste, and 23.5% consumed soft drinks several times a day. Dental attendance, defined as being seen by a dentist at prison, within the last year was reported by 37% of participants and 15.2% never received dental care. Most participants (85.2%) reported dental pain during the last year. The study showed a statistically significant correlation between the simplified oral hygiene index and the mean decayed score (r = 0.456, P &lt; 0.001). The mean DMFT of the sample significantly increased with advancing age (P = 0.023). Male participants (15.12 ± 7.94) demonstrated significantly higher mean DMFT score than females (10.03 ± 6.05) (P = 0.001). Similarly, significantly higher DMFT was found in Saudi (15.74 ± 7.91) versus non-Saudi participants (10.45 ± 6.41) (P &lt; 0.001). Those who used toothpaste (12.82 ± 6.95) had significantly lower mean DMFT score than those who did not use toothpaste (19.59 ± 8.58) (P = 0.006). A statistically significant relationship was observed between soft drink consumption and caries experience (P = 0.043).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Untreated decay was highly prevalent among inmates in this study. A statistically significant correlation was found between oral hygiene and caries experience, with advancing age, male gender, Saudi nationality, and frequent soft drink consumption being significantly associated","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1527"},"PeriodicalIF":3.1,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taurodontism and related dental anomalies: influence of maternal, prenatal, and postnatal factors in pediatric patients.","authors":"Ozemre Mehmet Ozgur, Mustuloğlu Seyma, Korkmaz Aynur, Kocak Topbas Nazan","doi":"10.1186/s12903-025-06530-0","DOIUrl":"10.1186/s12903-025-06530-0","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the association between taurodontism and maternal-child characteristics, as well as its relationship with other dental anomalies including hypodontia, hyperdontia, and pyramidal molars.</p><p><strong>Methods: </strong>Panoramic radiographs were obtained from 815 patients aged 9 to 15 years. A total of 62 children with taurodontism and their mothers agreed to participate. Other dental anomalies and taurodontism types were also recorded. Mothers completed a questionnaire that included the mother and child's demographic characteristics and potential etiological factors. The collected data were subjected to statistical analysis.</p><p><strong>Results: </strong>The most common form of taurodontism was hypotaurodontism, most frequently affecting the right maxillary first molar (43.5%). Heart disease (n = 5) was the most frequently observed systemic condition among children with taurodontism. A statistically significant association was observed between the number of taurodontic teeth and the presence of pyramidal molars (p < 0.05). Regression analysis revealed significant associations (p < 0.05) between the presence of more than two taurodontic teeth and several factors, including maternal smoking during pregnancy, a higher number of siblings, female sex, and consanguineous marriage. These findings may assist in identifying at-risk pediatric populations and underscore the importance of considering these variables in the clinical assessment of dental anomalies.</p><p><strong>Conclusions: </strong>Evaluating taurodontism in children with heart disease or pyramidal molars may contribute to early diagnosis and more effective management. The findings of this study highlight the need for increased clinician awareness and further research with larger sample sizes and healthy control groups to better understand the risk factors associated with taurodontism.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1526"},"PeriodicalIF":3.1,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}