BMC Oral Health最新文献

{"title":"Preliminary cytotoxicity assessment of Jaftex vs. chlorhexidine mouthwashes on human gingival fibroblasts and oral squamous cell carcinoma.","authors":"Hamed Saberikia, Mohammad Rashno, Fatemeh Babadi, Vahid Rakhshan","doi":"10.1186/s12903-025-05630-1","DOIUrl":"10.1186/s12903-025-05630-1","url":null,"abstract":"<p><strong>Background and objectives: </strong>Jaftex is a new herbal mouthwash that consists of the aqueous extract of Jaft oak, thymus, and the aqueous extract of Satureja Bachtiarica. Its cytotoxicity remains unknown.</p><p><strong>Methods: </strong>The sample size was determined as 180 specimens as 3 specimens for each of the 60 different combinations of 2 mouthwashes, 2 cell lines, 3 exposure times (24, 48, 72 h), and 5 mouthwash doses. Also, there were 36 positive and negative controls. Jaftex 1% and chlorhexidine 0.2% were sterilized and diluted 1:2, 1:4, 1:8, 1:16, and 1:32 of the original concentration. Each drug dilution was made available in triplicate. OCC and HuGu cells were exposed to these concentrations at 37 °C for 24 h (n = 60), 48 h (n = 60), and 72 h (n = 60). The optical densities (ODs) were measured for each of the 180 experimental specimens and 36 positive and negative specimens. Also the IC50 was calculated. The results were analyzed (α = 0.05).</p><p><strong>Results: </strong>The viability was much higher in the case of Jaftex compared with CHX. The viability was higher in OCC compared to HuGu. All pairwise comparisons between each two dosages were significant (all P values ≤ 0.013) in a way that by reducing the dosage, the viability increased.</p><p><strong>Conclusions: </strong>The toxicity of Jaftex was significantly lower than that of chlorhexidine. Also, the toxicity of both mouthwashes against the HuGu cell line was higher than the OCC-18 cell line. During 24, 48, and 72 h, the mouthwash toxicity increased significantly.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"379"},"PeriodicalIF":2.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro evaluation of cytotoxicity of fixed functional appliances.","authors":"Alper Balat, Hakan Gürcan Gürel, Nazlı Ece Ordueri","doi":"10.1186/s12903-025-05755-3","DOIUrl":"10.1186/s12903-025-05755-3","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to evaluate the cytotoxicity of fixed functional appliances that are commonly used in the treatment of Class II malocclusion caused by mandibular retrognathia, using the MTT cell viability assays [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] (Sigma Chemical Co., Milan, Italy).</p><p><strong>Materials and methods: </strong>The cytotoxicity of five different fixed functional appliances commonly used in orthodontic treatments was assessed. The appliances evaluated included Jasper Jumper (American Orthodontics, Wisconsin, USA), Power Scope (American Orthodontics, Wisconsin, USA), Herbst (American Orthodontics, Wisconsin, USA), Forsus™ Fatigue Resistant Device Kits (3 M, MN, USA), and Twin Force Bite Corrector (Henry Schein Orthodontics, California, USA). Assays were conducted using one appliance from each type, resulting in a total of seven groups. Cytotoxicity testing was performed using the MTT assay on a human gingival fibroblast (HGF) cell line. Data analysis was conducted using the Kruskal-Wallis test with a significance level of p = 0.05.</p><p><strong>Results: </strong>All appliances demonstrated cell viability rates exceeding 90%, categorizing them as non-cytotoxic under ISO 10993-5 standards. Herbst exhibited the highest proliferation index (2.62 ± 1.13), while Power Scope (2.05 ± 1.06) and Jasper Jumper (1.90 ± 1.23) showed the lowest indices. Despite these variations, statistical analysis revealed no significant cytotoxic effects when compared to the control group (p > 0.05). All appliances were confirmed as biologically safe for cell health.</p><p><strong>Conclusion: </strong>The findings demonstrate that all evaluated appliances exhibit a biocompatible interaction with HGF cells, with no evidence of adverse cytotoxic effects. These results support the safe clinical use of these fixed functional appliances in orthodontic treatment.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"375"},"PeriodicalIF":2.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of a carcinoma in situ of the tongue margin, using a Nd:YAG laser, cross-linked hyaluronic acid (xHyA) gel and a porcine pericardium resorbable membrane: a case report.","authors":"Roberta Iaria, Ilaria Giovannacci, Marco Meleti, Jair Carneiro Leão, Paolo Vescovi","doi":"10.1186/s12903-025-05701-3","DOIUrl":"10.1186/s12903-025-05701-3","url":null,"abstract":"<p><strong>Background: </strong>Oral tongue squamous cell carcinoma is the most prevalent cancer of the oral cavity. To date, the mainstay management for carcinoma in situ of the oral cavity is the surgical radical removal of the neoplastic tis-sue. This paper describes a new approach in the management of an in situ carcinoma of the tongue margin, treated surgically by the use of Nd:YAG laser, the application of cross-liked hyaluronic acid (xHyA) gel and the placement of a resorbable porcine pericardium membrane (PPM).</p><p><strong>Case presentation: </strong>The case involves a 49-years old male patient with no history of smoking and alcohol use, who presented a non-homogeneous leukoplakia of the right tongue border. The biopsy revealed high-grade lichenoid dysplasia, corresponding to severe epithelial dysplasia or carcinoma in situ (Tis), characterized by full-thickness dysplasia without stromal invasion.</p><p><strong>Conclusions: </strong>The case shows that the combined use of Neodimium laser surgery, xHyA gel and PPM is a viable option for promoting soft tissue regeneration in the oral cavity, enabling excellent clinical results in terms of healing medium-sized surgical defects. In addition, compared with other options for the reconstruction of surgical defects of the tongue, the clinical use of the association between these two materials has several biological advantages due to the absence of donor sites and high patient tolerability.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"378"},"PeriodicalIF":2.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of microplate spacing on mandibular ramus fracture fixation stability: a biomechanical finite element analysis.","authors":"Ruize Tang, Qing Cui, Shuo Ren, Unurjargal Khadbaatar, Jingxu Li","doi":"10.1186/s12903-025-05746-4","DOIUrl":"10.1186/s12903-025-05746-4","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect of different microplate spacing on the relative displacement of the fractured mandibular ramus during mastication after using double microplates for fixation, using finite element analysis. This study aims to provide a theoretical basis for clinical design of the distance between two microplates.</p><p><strong>Methods: </strong>Finite element models of the mandible, teeth, periodontal membrane, and microplates (Johnson & Johnson, thickness 1 mm) were established. A fracture line was set on the mandibular ramus from the sigmoid notch to the angle of the mandible, corresponding to the type I fracture line of the mandibular ramus. The experiment designed the distance between two microplates into 22 groups, with 2 mm as the initial distance and an increase of 1 mm per step, gradually increasing the distance between the two microplates to 23 mm. Friction contact was set between the two fracture fragments, and the bilateral condyles were fixed. A bite force of 230 N was applied to the bilateral first molars, and the relative displacement between the two fracture fragments under this load was calculated.</p><p><strong>Results: </strong>The results showed that as the distance between the microplates increased, the relative displacement gradually decreased, from 0.46751 mm at a distance of 2 mm to 0.105789 mm at a distance of 23 mm. The relative displacement at a distance of 20 mm was 0.147448 mm, which was below the clinical critical value of 0.15 mm for the direct healing.</p><p><strong>Conclusion: </strong>After using double microplates for fixation of mandibular ramus fractures, the stability of the fracture fixation during mastication increases with the increase in the distance between the two microplates. At a distance of 20 mm, While theoretically capable of achieving the criteria for direct healing, further clinical validation remains necessary.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"376"},"PeriodicalIF":2.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Assessment of two methods for detecting carious dentin: an in vitro study.","authors":"Joel White, Alfa Yansane, Puja Kukreti, Pragati Nahar, Paolo Orobia, Rachel Jensen, Leslie Plack, Ram Vaderhobli, Jonathan Mangum, Larry Jenson","doi":"10.1186/s12903-025-05740-w","DOIUrl":"10.1186/s12903-025-05740-w","url":null,"abstract":"","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"384"},"PeriodicalIF":2.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Necessity of selective neck dissection for T1-2N0 TSCC patients: a retrospective cohort study.","authors":"Guanzheng Chen, Xiangpan Kong, Zhien Feng, Jia Kang, Zhengxue Han, Bo Li","doi":"10.1186/s12903-025-05694-z","DOIUrl":"10.1186/s12903-025-05694-z","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to assess the prognosis of T1-2N0 stage tongue cancer patients who underwent surgery for the primary lesion without elective neck dissection and to identify the risk factors for prognosis.</p><p><strong>Methods: </strong>We retrospectively analyzed early-stage tongue cancer patients in our center. Statistical analyses were performed using SPSS and R software.</p><p><strong>Results: </strong>The study reviewed 168 patients, revealing a 3-year overall survival rate of 90.5%, a 3-year cervical lymph node metastasis-free survival rate of 73.2%, and a 3-year disease-specific survival rate of 89.3%. A depth of invasion of 3 mm showed significant prognostic value for overall survival (P = 0.001), cervical lymph node metastasis-free survival (P = 0.002), and disease-specific survival (P < 0.001). Patients were categorized into four subgroups (thick T1, thin T1, thick T2, and thin T2) to further explore the prognostic significance of depth of invasion across different T stage categories. The combination of T stage and a 3 mm depth of invasion demonstrated significant prognostic value in univariate analysis for overall survival (P = 0.002), cervical lymph node metastasis-free survival (P = 0.010), and disease-specific survival (P < 0.001). COX regression analysis confirmed the statistical significance of T stage combined with a 3 mm depth of invasion for overall survival (OR = 10.653; 95% CI, 2.394 to 47.404; P = 0.002) and lymph node metastasis-free survival (OR = 3.016; 95% CI, 1.365 to 6.667; P = 0.006).</p><p><strong>Conclusions: </strong>The findings highlight depth of invasion and T stage as key prognostic factors in early-stage tongue squamous cell carcinoma. Consideration of elective neck dissection is advised for patients with T2 tumors and a depth of invasion exceeding 3 mm to potentially enhance their prognosis.</p><p><strong>Trial registration: </strong>The current research was registered in Chinese Clinical Trial Registry on April 8, 2021. The trial registration number is ChiCTR2100045188.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"383"},"PeriodicalIF":2.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of edutainment use in video-based learning on oral health education for school-age children: a randomized clinical trial.","authors":"Wanwisa Lekaram, Pattarawadee Leelataweewud, Pornpailin Kasemkhun","doi":"10.1186/s12903-025-05717-9","DOIUrl":"10.1186/s12903-025-05717-9","url":null,"abstract":"<p><strong>Background: </strong>Entertainment platforms have become more popular among children since the COVID-19 outbreak. The entertainment designed for education; \"edutainment\" could be a promising learning tool on oral health education (OHE). This study aimed to evaluate the effectiveness of edutainment use for OHE in school-age children.</p><p><strong>Methods: </strong>A total of 210 students (age range 9.2-10.8 years) were included. The three-arm parallel randomized controlled trial was conducted in three schools, receiving the same contents of OHE with different learning methods; classroom learning (CL), edutainment in video-based learning with and without repetition at a three-month follow-up (EVBL and EVBL-R). The knowledge, behavior, behavioral intention score, and oral health (OH) status; visble plaue (VPI) and gingival index (GI) were evaluated at baseline, immediate post-intervention, 3, and 6 months. Differences within and between groups for knowledge scores and OH status were analyzed by repeated measures and one-way ANOVA, respectively, and for both behavior and behavioral intention scores, Friedman's two-way analysis of variance and Kruskal-Wallis test were analyzed, respectively, at a significant level of 0.05.</p><p><strong>Results: </strong>The knowledge score was significantly higher in CL for two out of three content domains (p = 0.01, p < 0.001) yet immediately improved within all groups (p < 0.001) with the range of 26.58-53.35% vs. 4.12-29.77% of both EVBLs. No significant difference was found in the behavior and behavioral intention scores among groups. EVBL and EVBL-R had significantly improved behavior scores throughout their follow-ups (p = 0.017, p = 0.006) with the range of 1.19-28.13% vs. 1.90-15.16% of CL and had a significant improvement for VPI (p < 0.001) or 32.5-57.08% vs. 36.45-38.79% of CL. There was no significant difference in GI, but it significantly improved only within the EVBL-R group after the repetition.</p><p><strong>Conclusion: </strong>EVBL was comparable to the CL in encouraging positive behaviors, while the CL was preferable for providing core knowledge. EVBL was more applicable to how-to content, and the repetition at least every three months might be able to promote a better OH status.</p><p><strong>Trial registration: </strong>The trial was registered in the Thai Clinical Trials Registry under the number TCTR20240816001 on 16/08/2024 (retrospective registration).</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"381"},"PeriodicalIF":2.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gingival thickness: effects on gingival wound healing.","authors":"Kalia Theodorou, Ai Ni, Dimitris N Tatakis","doi":"10.1186/s12903-025-05593-3","DOIUrl":"10.1186/s12903-025-05593-3","url":null,"abstract":"<p><strong>Background: </strong>Although available evidence indicates that gingival thickness may affect periodontal surgical outcomes, there are no studies on the effect of gingival thickness on gingival excisional wound healing. This prospective study aimed to assess the effect of gingival thickness on the healing of standardized experimental gingival wounds.</p><p><strong>Methods: </strong>Healthy non-smokers with thick or thin gingiva were recruited. Standardized circular buccal gingival excisional wounds were created. Follow-up visits were conducted on postoperative day 3 (D3), 7 (D7), and 14 (D14). Healing Score Index (HSI) and H₂O₂ test were used to assess wound healing and epithelialization, respectively. Digital photographs were obtained to assess wound surface area. Patient-centered outcomes were assessed using custom and OHIP-14 questionnaires.</p><p><strong>Results: </strong>Twenty-six volunteers (24-36 years old) with thin/thick gingiva (n = 13 per group, age- and sex-matched) completed the study. HSI predictably increased from D3 to D14, without significant intergroup differences at any time point (p ≥ 0.99). Wound epithelialization was 0% on D3, 61-69% on D7, and 92-100% on D14, without significant intergroup differences at any time (p ≥ 0.99). Over 95% of the immediate postoperative wound area was closed by D14, without significant intergroup differences at any time (p ≥ 0.25). Although OHIP-14 scores did not differ significantly between groups (p ≥ 0.99), thin group reported more pain after the anesthesia wore off (day of the surgery; p = 0.0391).</p><p><strong>Conclusions: </strong>Within the limitations of the present study, standardized buccal gingival wounds heal predictably within a short period of time, with no evidence that clinically determined gingival thickness has any effects on the wound healing.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"382"},"PeriodicalIF":2.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot study on the application of a digital dental teaching evaluation system in Class II cavity preparation teaching.","authors":"Yuejiao Zhang, Xiaolan Li, Xi Wei, Jiexuan Xiao, Qi Zhang, Sui Mai","doi":"10.1186/s12903-025-05695-y","DOIUrl":"10.1186/s12903-025-05695-y","url":null,"abstract":"<p><strong>Objective: </strong>To explore the feasibility of applying the digital evaluation system in the homogeneous training and qualification evaluation of teaching faculty in the preclinical simulation teaching of G.V. Black Class II cavity tooth preparation in operative dentistry.</p><p><strong>Methods: </strong>Eighteen clinicians who graduated with Ph.D. and were about to participate in the operative dentistry preclinical teaching at the Hospital of Stomatology, Sun Yat-sen University, were selected to practice the G.V. Black Class II cavity tooth preparation of the left mandibular first molar by using the Aizhixing Digital Dental Virtual Teaching Evaluation System DHC210. Through continuous practice and assessment, we evaluated whether there were changes in their examination scores and operation time after practicing with multiple teeth. Meanwhile, we evaluated the condition of Class II cavity tooth preparation before and after practices using Fair Grader 2000, a Dental Digital Teaching Practice Evaluation System, and combined it with questionnaires to examine the teaching effectiveness of this training.</p><p><strong>Results: </strong>As the number of exercises increased, there was a tendency for the result scores of the four tests of Aizhixing to increase (P > 0.05), and the operating time was progressively less (P < 0.05). The results of Fair Grader 2000 showed that dental clinicians who had completed their standardized residency training had higher and more stable scores than those who were ongoing (P < 0.05). The questionnaire survey results showed that it was necessary to apply Aizhixing to Class II cavity tooth preparation teaching activities, which can effectively improve students' theoretical knowledge and the level of cavity preparation skills.</p><p><strong>Conclusion: </strong>The application of the digital real-time evaluation system of Aizhixing and the digital evaluation system help to improve the efficiency and objective assessment of Class II cavity tooth preparation, which provides a certain reference basis for achieving high-quality and homogeneous teaching and reform of oral endodontics.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"372"},"PeriodicalIF":2.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11900384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced or delayed? a retrospective study of skeletal maturation in children with a cleft lip and palate.","authors":"Xiaoyi Wu, Wenying Kuang, Gufeng Liu, Xiao Liu, Shiyu Yuan, Luyi Zhang, Cui Huang, Wenjun Yuan","doi":"10.1186/s12903-025-05715-x","DOIUrl":"10.1186/s12903-025-05715-x","url":null,"abstract":"<p><strong>Background: </strong>The developmental patterns of children with cleft lip and palate (CLP) can affect the therapeutic effects. However, a consensus has not been reached on whether the development of children with CLP is delayed or advanced. We aimed to characterize the developmental patterns of children with CLP by skeletal maturation and to explore the relationship between skeletal maturation and dentition in children with CLP.</p><p><strong>Methods: </strong>This retrospective study included 425 children, aged 4-18 years, categorized into three groups: unilateral cleft lip and palate (UCLP, 157), bilateral cleft lip and palate (BCLP, 134), and non-cleft controls (NCLP, 134). Skeletal maturation stages were assessed using the 5-stage cervical vertebral maturation (CVM) method. Adenoidal and tonsil hypertrophy was also assessed based on cephalometric radiographs. Dentition stages were evaluated based on the eruption of mandibular teeth. Logistic regression models were used to analyze the relationship between CLP and skeletal maturation, adjusting for adenoidal and tonsil hypertrophy and sex. The children were further subgrouped by sex, cleft type, and age to examine developmental patterns and the relationship between skeletal maturation and dentition.</p><p><strong>Results: </strong>In both sexes, children with CLP exhibited delayed skeletal maturation at specific developmental stages compared to NCLP children, but eventually caught up to their non-cleft peers. This delay and subsequent catch-up occurred approximately three years earlier in girls with CLP than in boys. While dentition stages showed a strong correlation with CVM stages, the diagnostic utility of dentition for assessing skeletal maturation was found to be limited.</p><p><strong>Conclusions: </strong>Children with CLP exhibit a delayed onset of the growth spurt, followed by a period of catch-up growth. Additionally, dentition stage should not be used as a surrogate marker for skeletal maturation when evaluating the developmental potential of children with CLP.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"374"},"PeriodicalIF":2.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}