BMC Oral Health最新文献

{"title":"Assessment of oral hygiene parameters in association to eating behaviors and healthy eating self-efficacy in school-aged children.","authors":"Seda Ceren Gökçek, Sabiha Ceren İlisulu","doi":"10.1186/s12903-024-05296-1","DOIUrl":"10.1186/s12903-024-05296-1","url":null,"abstract":"<p><strong>Background: </strong>Eating behavior are a broad category influenced by a various personal, social, cultural, environmental, and economic factors. The objective of this study was to evaluate the oral hygiene status of school-aged children in relation to their eating behavior and healthy eating self-efficacy.</p><p><strong>Methods: </strong>The study was carried out with the participation of 225 children aged 7-9 years. Parents carried out the Children's Eating Behavior Questionnaire (CEBQ) to assess eating behaviors and provided sociodemographic information. Oral examinations of the children were provided according to plaque index (PI), gingival index (GI), simplified oral hygiene index (OHI-S), dmft and DMFT and, the Healthy Eating Self-Efficacy Scale (HESES) was administered to the children. For statistical analysis, a consistent partial least squares structural equation model (PLS-SEM) technique was utilized.</p><p><strong>Results: </strong>A statistically significant negative correlation was found between the Healthy Eating Self-Efficacy Scale and the PI, GI, OHI-S, dmfs (p < 0.001) and DMFS (p = 0.002). Emotional undereating significantly negatively affected dmfs (p = 0.021), while emotional overeating had a significant positive effect on DMFS (p = 0.036). None of the eating behavior subgroups in children showed a significant relationship with self-efficacy. Additionally, higher self-efficacy (p = 0.001) and food fussiness (p = 0.001) were found in children from high-income families, while emotional overeating (p < 0.001) and desire to drink (p = 0.009) were observed in children from middle-income families.</p><p><strong>Conclusion: </strong>This study reveals a significant relationship between healthy eating self-efficacy and oral hygiene in children. Higher self-efficacy correlates with better oral health, while emotional eating negatively impacts dental outcomes. Socioeconomic factors also play a role, suggesting that interventions should target self-efficacy and emotional eating to improve both eating behaviors and oral health in school-aged children.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"24 1","pages":"1551"},"PeriodicalIF":2.6,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11673282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing submandibular fossa visibility on panoramic images: a comparative CBCT study.","authors":"Ceren Özeren Keşkek, Emre Aytuğar","doi":"10.1186/s12903-024-05364-6","DOIUrl":"10.1186/s12903-024-05364-6","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the variables affecting the visibility of the submandibular fossa (SF) on panoramic images, including SF depth and types, age, gender, presence or absence of tooth, location of mandibular canal, and alveolar bone thicknesses.</p><p><strong>Methods: </strong>Cone beam computed tomography (CBCT) images and conventional panoramic images of 150 patients were analyzed retrospectively. The visibility of the SF on panoramic images was compared with its depth and adjacent alveolar bone thicknesses on CBCT. Predictive variables affecting the SF visibility were identified, and binary logistic regression analysis was performed.</p><p><strong>Results: </strong>Based on CBCT measurements, the SF depth was ≥ 2 mm in 65% of the hemi-mandibles with radiolucent area (26.7%). A significant difference was observed between the SF visibility on panoramic images and its depth, and the lingual cortical bone thickness as measured on CBCT. When the SF was visible and not, the mean SF depth was 2.24 ± 0.97 mm and 1.6 ± 0.8 mm, and lingual cortical bone thickness was 1.27 ± 0.47 mm and 1.53 ± 0.49, respectively. Regression analysis revealed significant associations between SF visibility and gender (Odds ratio (OR) = 3.28, 95% confidence interval (CI): 1.77-6.09), age (OR = 0.96, 95% CI: 0.94-0.98), SF depth (OR = 2.01, 95% CI: 1.43-2.81), and lingual cortical bone thickness (OR = 2.02, 95% CI: 1.30-3.16).</p><p><strong>Conclusions: </strong>A prominent radiolucent SF on panoramic images indicates a deeper fossa and thinner lingual cortical bone, necessitating caution by clinicians during surgical planning.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"24 1","pages":"1556"},"PeriodicalIF":2.6,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11673811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endodontic emergency patients' profile and treatment outcome - a prospective cohort study.","authors":"Sivakami Rethnam Haug, Margrethe Røegh, Inge Fristad","doi":"10.1186/s12903-024-05338-8","DOIUrl":"10.1186/s12903-024-05338-8","url":null,"abstract":"<p><strong>Background: </strong>Toothache is a debilitating condition, often with mild to excruciating pain, swelling, eating difficulties and insomnia. This study aims to delineate the profiles of patients seeking emergency dental care, focusing on the diagnosis, treatment, and outcomes following non-surgical root canal treatment.</p><p><strong>Methods: </strong>This prospective cohort study was conducted from 2012 to 2021 at the Section for Endodontics, Department of Clinical Dentistry, University of Bergen, Norway. A total of 281 emergency patient forms were analyzed. Data registered included patient demographics, dental history, chief complaints, medications used, diagnostic results, treatments provided and outcome.</p><p><strong>Results: </strong>A total of 272 patients (272 teeth) were included in the study. Pain was the predominant complaint (98.5%), where only 57.4% of the patients managed to localize pain to a specific tooth. The mean age of patients was 51.2 years with no significant gender differences. The maxillary right first molar (15.4%) was the most frequent tooth needing treatment. The majority of the patients had experienced pain for three days before they attended the emergency appointment. The most frequently used drug for pain management was paracetamol which was stated to have little effect. Teeth that needed endodontic treatment often had restorations rather than caries. The most frequent diagnoses were pulpitis (26.8%) followed by necrotic pulp (25.4%) and previously root filled teeth (22.8%). Root canal treatment was performed on 60% of the teeth and a success rate of 95% was registered at one-year recall.</p><p><strong>Conclusions: </strong>There was no singular diagnostic cause leading patients to seek an emergency appointment, highlighting the necessity of a thorough diagnostic procedure. Over the counter pain medications have little effect on alleviating dental pain, often resulting in desperate measures of self-medication. 60% of the teeth needing emergency treatment had previous coronal restorations such as fillings or crowns, indicating that conservative treatment does not appear to fully protect against future pulpal disease. The good prognosis of root canal treatment for teeth with acute symptoms supports recommending dentists to attempt root canal treatment rather than opting for tooth extraction.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"24 1","pages":"1557"},"PeriodicalIF":2.6,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11674510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience of primary dental care teams in managing the oral health of oncology patients.","authors":"Callum Wemyss, Ahmed Abdulsalam, Laura Beaton, Kirsten Perry, Claire Scott, Douglas Stirling, Michele West","doi":"10.1186/s12903-024-05203-8","DOIUrl":"10.1186/s12903-024-05203-8","url":null,"abstract":"<p><strong>Background: </strong>Estimates suggest that one in two people will experience cancer in their lifetime. Cancer and the treatment of cancer can have several impacts on oral health. It is therefore important that dental teams are supported in managing this group of patients especially in primary care dental settings, where most of these patients will first present to dental services. The aim of this study was to explore current practice and beliefs about managing patients with, or who have had, cancer in primary dental care settings.</p><p><strong>Methods: </strong>Online focus groups consisting of dental professionals working in primary care dental settings in Scotland, were conducted. Areas explored included cancer types seen, perceived role, challenges, and areas where further support was desired. Data from focus group transcripts were analysed using thematic analysis.</p><p><strong>Results: </strong>Four focus groups were conducted with a total of fifteen participants. Themes identified related to the types of cancers seen in primary care dental settings; communication between dental and medical teams; patient experience; mixed healthcare messages; patient engagement with their healthcare; challenges in treatment planning; apprehension about what can safety managed in primary care; and wider system factors influencing the management of patients with, or who have had, cancer. Areas where support exists but further support is desired were also identified.</p><p><strong>Conclusions: </strong>Challenges appear to exist in the provision of oral healthcare for patients with, or who have had, cancer. This study has indicated several areas where further support could be targeted. The results should be validated by further research.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"24 1","pages":"1554"},"PeriodicalIF":2.6,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11673281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of professional oral health care on the oral health of older people: a systematic review and meta-analysis.","authors":"Saber Azami-Aghdash, Seyedeh Sara Ebadi, Mehran Sardareh, Fatemeh Pournaghi-Azar, Shahin Karami, Seyedeh Narges Pouyan, Naser Derakhshani","doi":"10.1186/s12903-024-05382-4","DOIUrl":"10.1186/s12903-024-05382-4","url":null,"abstract":"<p><strong>Introduction: </strong>In recent years, Professional Oral Health Care (POHC) has received serious attention for improving Oral Health Indicators (OHIs) in older people. Therefore, the present study aims to evaluate the impact of POHC on the oral health of older people through a systematic review and meta-analysis of existing studies and evidence.</p><p><strong>Methods: </strong>Published articles until August 1, 2023, were searched in databases such as Scopus, PubMed, and Web of Science. Manual searches on Google Scholar, reference checks, citation checks, and gray literature were also conducted. Stata software was utilized for meta-analysis using a random-effects model.</p><p><strong>Results: </strong>Out of 488 studies reviewed, 13 articles were included. All studies were conducted in high-income countries, with 11 studies conducted in elderly care centers. The status of dental plaque, oral health, and mucosal plaque in the POHC group was significantly better compared to the control group. The average dental plaque index score was significantly better than before the intervention. Despite improvement in both groups, the tongue coating index did not show statistically significant improvement. Results of other unaudited indicators also indicated a significantly better status in the intervention group than in the control group.</p><p><strong>Conclusion: </strong>Although the results of the current study demonstrated the high effectiveness of professional oral health care, improving almost all OHIs in older people, further well-established studies in this field are still needed.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"24 1","pages":"1558"},"PeriodicalIF":2.6,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11673601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antifungal susceptibility profile of Candida species and uncommon yeasts from drug abusers with oral candidiasis.","authors":"Aynaz Ghojoghi, Sadegh Khodavaisy, Ali Zarei Mahmoudabadi, Mahnaz Fatahinia","doi":"10.1186/s12903-024-05368-2","DOIUrl":"10.1186/s12903-024-05368-2","url":null,"abstract":"<p><p>In Iran, there is limited information regarding the species distribution and antifungal susceptibility profiles of yeast isolates from drug addicts suffering from oral candidiasis (OC). In this study, 104 yeast isolates, including 98 Candida species and 6 uncommon yeasts, were collected from 71 drug abusers with OC. The susceptibility profiles of Candida spp. and uncommon yeasts to amphotericin B (AMB), itraconazole (ITC), nystatin (NYC), fluconazole (FLC), and caspofungin (CAS) were evaluated using the CLSI broth microdilution method. The prevalence of OC in the sampled population was found to be 29%. The susceptibility profile of Candida spp. revealed remarkable sensitivity, with 100% and 99% of isolates susceptible to NYC and AMB, respectively. However, concerning levels of resistance or non-wild-type minimum inhibitory concentrations (MICs) were observed, with 13.2% of Candida isolates showing resistance to FLC, 13.2% to ITC, and 16.3% to CAS. Notably, 35.2% of patients showed mixed yeast species, while 5.1% of Candida isolates exhibited multidrug resistance. The analysis of the uncommon yeast species showed that the overall frequencies of the highest MICs were observed for CAS. Furthermore, within the six non-Candida species identified, Hanseniaspora opuntiae and one isolate of Pichia kluyveri exhibited resistance to FLC and ITC, respectively, while all non-Candida species were susceptible to AMB and NYC. Additionally, one isolate of Pichia kluyveri exhibited simultaneously high MICs to two drugs ITC and CAS. Furthermore, the Hanseniaspora opuntiae isolate showed high MICs to CAS and FLC. The findings from the present study suggest that AMB and NYC can be suitable choices for empiric treatment of both common Candida species and uncommon yeast infections in substance abuse patients.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"24 1","pages":"1555"},"PeriodicalIF":2.6,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11673824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effectiveness of advanced platelet-rich fibrin, photobiomodulation, pentoxifylline, and Alveogyl in the treatment of alveolar osteitis: a randomized controlled clinical trial.","authors":"Alper Yuzbasioglu, Cennet Neslihan Eroglu","doi":"10.1186/s12903-024-05372-6","DOIUrl":"10.1186/s12903-024-05372-6","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Alveolar osteitis is a type of small-scale osteomyelitis of the alveolar bone that occurs after tooth extraction, the etiology of which remains unknown, and alternative methods are being investigated for its treatment. The aim of this study was to compare the effectiveness of advanced platelet-rich fibrin (A-PRF), photobiomodulation (PBM), and Alveogyl (butamben, idoform, eugenol), which have shown success in the treatment of alveolar osteitis, with that of pentoxifylline (PTX) to determine whether PTX could be an alternative treatment for alveolar osteitis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study included 80 healthy volunteers diagnosed with alveolar osteitis in the extraction sockets of their mandibular first, second, and third molars. The patients were divided into four groups, with 20 patients in each group: A-PRF, PBM, PTX, and Alveogyl. After physiological saline irrigation, the patients were treated according to their respective group. The patients were followed up on the 2nd, 4th, 7th, and 14th days. Primary outcomes included pain assessment and the evaluation of soft tissue healing. Pain was assessed via the visual analog scale (VAS), soft tissue healing was evaluated via the Landry Healing Index (LHI), and granulation tissue was measured. Age and sex were used as study variables. The data were analyzed via ANOVA and post hoc tests to compare the treatment groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;There was no statistically significant difference in the mean VAS score between the groups (p &gt; 0.05). However, the degree of reduction in the VAS score increased in the following order: A-PRF, PBM, PTX, and Alveogyl. In the LHI data, there was a statistically significant difference in the mean scores between the groups, with Alveogyl being favored preoperatively and PBM being favored at the 2nd week (p &lt; 0.05). Statistically significant differences were observed in granulation tissue measurements on the preoperative day, as well as on Days 4 and 7, in favor of Alveogyl on Day 4 and PBM on Day 7 (p &lt; 0.05). The greatest increase in granulation tissue scores was observed in the A-PRF group, whereas the greatest change in LHI scores was observed in the PBM group. PTX did not produce a statistically significant difference in soft tissue healing, although there were periods when it showed results similar to those of Alveogyl and PBM. There were significant differences between the VAS score, granulation tissue score and LHI score in terms of age and sex within the time periods followed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The findings of this study indicate that although PTX has similar efficacy in terms of wound healing and analgesic properties to the methods used, it does not offer significant advantages. Compared with other methods, A-PRF and PBM have provided better results in the treatment of alveolar osteitis, particularly regarding pain and soft tissue healing.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Trial registration: &lt;/strong&gt;The stu","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"24 1","pages":"1559"},"PeriodicalIF":2.6,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11673614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of 3D printing orientation on accuracy, properties, cost, and time efficiency of additively manufactured dental models: a systematic review.","authors":"Mohammed Ahmed Alghauli, Sarah A Almuzaini, Rola Aljohani, Ahmed Yaseen Alqutaibi","doi":"10.1186/s12903-024-05365-5","DOIUrl":"10.1186/s12903-024-05365-5","url":null,"abstract":"<p><strong>Background: </strong>The evidence on the effect of printing orientation on dimensional accuracy and properties of resinous dental models is unclear. This systematic review aimed to assess the impact of printing orientation on the accuracy and properties of additively manufactured resinous dental models, besides the cost, material consumption, and time efficiency at different orientations.</p><p><strong>Methods: </strong>A comprehensive web search (PubMed, Scopus, Cochrane) was performed in July 2024 without language restrictions. The included studies were assessed using the modified consort statement for laboratory studies on dental materials. The outcomes were accuracy and surface quality, besides the cost and time efficiency of additively manufactured dental models printed in different directions.</p><p><strong>Results: </strong>Following PRISMA guidelines, 14 records were included. Most records favored horizontally printed models with minor controversies regarding accuracy, material consumption, time, and cost efficiency. While orientation can influence surface quality, it is often more significantly affected by factors such as the printing technology used, the material properties, and the layer thickness.</p><p><strong>Conclusions: </strong>Horizontal orientation has proven to be the most efficient for producing dental models, particularly for single-model manufacturing, due to its superior time and cost savings. However, large-scale and overnight massive production favors the vertical orientation since the platform accommodates twice to triple the models' numbers as horizontal orientation. The majority of studies favor horizontal orientation for its accuracy. Choosing the optimal orientation in additive manufacturing not only ensures precision of dental models, improving the fit of restorations and prostheses, but also leads to significant reductions in production time, material usage, and energy consumption, ultimately minimizing environmental impact.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"24 1","pages":"1550"},"PeriodicalIF":2.6,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11673669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibula flap reconstruction for maxillary stage 3 medication-related osteonecrosis of the jaw from recipient and donor site perspectives: a preliminary single-center study.","authors":"Yuhan Lin, Jin Wang, Yongzhen Lai, Chuanqing Mao, Meng Lu, Chengyong Wang, Qiming Ouyang, Yue He, Weihui Chen","doi":"10.1186/s12903-024-05306-2","DOIUrl":"10.1186/s12903-024-05306-2","url":null,"abstract":"<p><strong>Background: </strong>While the surgical treatment of mandibular stage 3 medication-related osteonecrosis of the jaw (MRONJ) is well-documented, research on maxillary stage 3 MRONJ is limited. Antiresorptive medications can induce MRONJ and atypical femoral fracture (AFF), but their impact on the feasibility of using fibula flaps for reconstruction remains controversial. This study aimed to assess the surgical outcomes and functional recovery of fibula flap reconstruction for maxillary stage 3 MRONJ, considering both recipient and donor site outcomes.</p><p><strong>Methods: </strong>This retrospective study included patients with maxillary stage 3 MRONJ who underwent fibula flap reconstruction. Demographic and clinical features, postoperative complications, long-term outcomes and functional recovery of both recipient and donor sites were analyzed. Long-term outcomes included the survival of fibula flaps, the incidence of fibula graft or tibia fractures, recurrence of MRONJ, and patient survival status. Function assessments focused on speech, swallowing, and ankle joint.</p><p><strong>Results: </strong>Seven patients (two with multiple myeloma, five with bone metastases) were included. Two patients experienced delayed healing at the donor site, both of whom recovered within two months postoperatively. All fibula flaps survived with primary healing. There were no recurrences of MRONJ or fractures of fibula graft or tibia. The mean speech function score was 28.00 ± 12.03, the mean swallowing function score was 2.86 ± 2.79, the mean pain score of donor site was 2.71 ± 2.29, and the mean ankle function score was 94.43 ± 4.35.</p><p><strong>Conclusion: </strong>Fibula flap reconstruction is feasible for maxillary stage 3 MRONJ, yielding satisfactory surgical outcomes and functional recovery.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"24 1","pages":"1553"},"PeriodicalIF":2.6,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11674523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the basement membrane-related genes ITGA7 and its regulatory role in periodontitis via machine learning: a retrospective study.","authors":"Huihuang Ye, Xue Gao, Yike Ma, Shuai He, Zhihui Zhou","doi":"10.1186/s12903-024-05201-w","DOIUrl":"10.1186/s12903-024-05201-w","url":null,"abstract":"<p><strong>Background: </strong>Periodontitis is among the most prevalent inflammatory conditions and greatly impacts oral health. This study aimed to elucidate the role of basement membrane-related genes in the pathogenesis and diagnosis of periodontitis.</p><p><strong>Methods: </strong>GSE10334 was used for identification of hub genes via the differential analysis, protein-protein interaction network, MCC and DMNC algorithms, and evaluation via LASSO regression and support vector machine analysis to identify basement membrane-related markers in patients with periodontitis. Findings were validated by analysis of the GSE16134 dataset and quantitative reverse transcription PCR. The regulatory interplay among lncRNAs, miRNAs, and mRNAs was investigated through multiple databases. Immune infiltration analysis was performed to assess the immune landscape in periodontitis.</p><p><strong>Results: </strong>ITGA7 was identified as a key gene for periodontitis, as supported by machine learning analysis, validation of expression, and receiver operating characteristic analysis from external datasets. Immune infiltration analysis revealed significant associations between ITGA7 expression and the infiltration of numerous immune cells implicated in periodontitis. Additionally, our findings suggest that the expression of the lncRNA LINC-PINT is significantly increased in periodontitis, and that it can modulate ITGA7 expression through hsa-miR-1293.</p><p><strong>Conclusion: </strong>ITGA7 is a potential diagnostic and therapeutic target for periodontitis. The LINC-PINT/hsa-miR-1293/ITGA7 axis and the relationship between ITGA7 and immune infiltration provide new insights into the molecular mechanisms underlying periodontitis and highlight potential avenues for clinical intervention.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"24 1","pages":"1548"},"PeriodicalIF":2.6,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}