BMC Oral Health最新文献

{"title":"Comparison of intraoral scanner accuracy before and after calibration: an in vitro study.","authors":"Mehmet Gümüş Kanmaz, Genta Agani Sabah, Melin Balcı, Müfide Bengü Erden","doi":"10.1186/s12903-025-06584-0","DOIUrl":"10.1186/s12903-025-06584-0","url":null,"abstract":"<p><strong>Background: </strong>Intraoral scanners are an essential part of modern digital dentistry, yet the influence of calibration on their accuracy remains underexplored. This in vitro study aimed to evaluate the effect of calibration on the scanning accuracy of the TRIOS 3 intraoral scanner after a noncalibrated period of 324 days.</p><p><strong>Methods: </strong>Digital impressions of upper and lower full-arch phantom jaw models were obtained before and after calibration using the TRIOS 3 intraoral scanner (3Shape, Copenhagen, Denmark; software version 22.1.1). A total of 20 scans (five before and five after calibration for each jaw) were acquired by a single experienced operator. Reference scans were obtained with an extraoral scanner (E4, 3Shape, Denmark). Linear measurements (intermolar and interpremolar) and three-dimensional superimposition parameters (Absolute Average, Root Mean Square, and (90-10)/2) were used to assess trueness and precision. All measurements were performed using Medit Link software (version 3.3.6; Medit).</p><p><strong>Results: </strong>Assessment of method error demonstrated excellent intrarater reliability for all trueness and precision parameters (ICC > 0.994, P < 0.001). Statistical analyses revealed minor differences in linear measurements and three-dimensional superimposition values before and after calibration, none of which reached statistical significance (P > 0.05). Regarding trueness, the upper jaw showed slightly increased Absolute Average (0.068 ± 0.004) and (90-10)/2 values (0.093 ± 0.006) after calibration compared to before calibration (0.065 ± 0.003 and 0.087 ± 0.006, respectively), while the lower jaw exhibited higher Root Mean Square values after calibration (0.088 ± 0.008) than before (0.076 ± 0.006). Precision results showed a slightly increased Absolute Average (0.029 ± 0.003), Root Mean Square (0.064 ± 0.006) and (90 - 10)/2 (0.036 ± 0.006) values in the upper jaw, and Root Mean Square (0.095 ± 0.010) values in the lower jaw after calibration. Trueness and precision of linear measurements also showed a general decrease after calibration in both jaws, though the differences were not statistically significant (P > 0.05).</p><p><strong>Conclusions: </strong>The findings of this study show that the TRIOS 3 intraoral scanner maintained its accuracy without calibration for up to 324 days, suggesting that occasional deviations from manufacturer-recommended calibration intervals may not compromise scan quality. However, adherence to routine calibration is recommended until further evidence is available.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1186"},"PeriodicalIF":2.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and microbial study of reinforced 3D-printed maxillary denture base resin: a randomized trial.","authors":"Eman Mohamed Ahmed Teama, Hoda Mohamed Amin Rashad, Eman Abd El-Salam Mohamed Shakal, Eman Elsayed Hegazy","doi":"10.1186/s12903-025-06601-2","DOIUrl":"10.1186/s12903-025-06601-2","url":null,"abstract":"<p><strong>Statement of problem: </strong>The 3D-printed denture base resin needed reinforcement.</p><p><strong>Purpose: </strong>To evaluate the effects of adding nano ZrO2 and nano TiO2 on microbial colonization and patient satisfaction with 3D-printed maxillary complete dentures.</p><p><strong>Materials and methods: </strong>Twenty-four patients who needed complete dentures were randomly distributed into three equal groups. Group I: Patients used maxillary complete dentures 3D printed without the addition of any additives. Group II: Patients used maxillary complete dentures 3D after reinforcement by Nano-ZrO₂ (0.4%) by weight. Group III: Patients used maxillary complete dentures 3D printed after reinforcement by Nano-TiO₂ (0.4%) by weight. For microbial evaluation, a cotton swab was taken from the mucosa of the palate and the intaglio surface of maxillary dentures, and microbial colonization was evaluated by calculating the number of colony-forming units of S. aureus on mannitol salt agar plates and C. albicans on Sabouraud's dextrose agar plates after 48 h of incubation at insertion, 6 months, 12 months and 18 months. Patient satisfaction was evaluated 15 days after insertion and at 6, 12, and 18 months. The values of microbial colonization and patient satisfaction were analyzed via repeated-measures ANOVA followed by Tukey's multiple comparison test.</p><p><strong>Results: </strong>No significant differences in microbial colonization were detected among the three groups concerning Staphylococcus aureus in the palatal mucosa. There was a significant difference between Group I, the lowest antimicrobial group, and the other groups, while between Groups II and III, there was no significant difference in the number of S. aureus on the fitting surface of the denture. There were significant differences between Group II, the highest antifungal group, and the other groups at 12 and 18 months concerning Candida albicans in the palate and in the dentures. There was a significant difference in patient satisfaction between Group I, the lowest, and the other groups, whereas there was no significant difference between Groups II and III.</p><p><strong>Conclusion: </strong>Compared with the other groups, the nano-ZrO₂ group presented greater antimicrobial effects until 18 months, whereas the nano-TiO2 group presented antibacterial effects until 18 months and antifungal effects until 6 months. The addition of nano-ZrO₂ and nano-TiO₂ to 3D-printed denture base resin improved the aesthetic, speech, masticatory efficiency, hygiene, and comfort of patients.</p><p><strong>Trial registration: </strong>The trial was registered in the Clinical Trials Registry under the number NCT06921577 on 10/04/2025 (retrospective registration).</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1192"},"PeriodicalIF":2.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors related to oral healthcare utilisation by individuals 45 and older who live in the community: longitudinal National data from the health, aging, and retirement in Thailand project, 2015-2022.","authors":"Supa Pengpid, Karl Peltzer, André Hajek, Razak M Gyasi","doi":"10.1186/s12903-025-06467-4","DOIUrl":"10.1186/s12903-025-06467-4","url":null,"abstract":"<p><strong>Background: </strong>Few studies have longitudinally assessed the prevalence and factors associated with oral healthcare utilisation (OCU) in older adults. This study aimed to estimate the prevalence and factors associated with OCU based on 4-wave national longitudinal data from Thailand.</p><p><strong>Methods: </strong>Analysis was done on four waves of Health, Ageing, and Retirement in Thailand (HART) investigations carried out in 2015, 2017, 2020, and 2022 (analytical baseline sample N = 2775). The number of past 12 months of oral healthcare visits was assessed by self-report. Using the panel data structure of four study waves, the impact of time-dependent regressors on healthcare utilization was estimated using conditional fixed effects (FE) logistic regressions. We used the Andersen model as the theoretical foundation.</p><p><strong>Results: </strong>The prevalence of OCU in the past 12 months at baseline assessment was 7.4%. Regressions showed the importance of need factors (poor self-rated physical health, loneliness, number of chronic conditions, weight loss, meal skipping and wearing dentures), predisposing characteristics (decreasing age), and enabling and disabling resources (private health insurance, Civil Servants Medical Benefit Scheme, Social Security Scheme, or Other Scheme, transitioning to live alone, higher qualify of life or happiness and higher depressive symptoms) in relation to OCU.</p><p><strong>Conclusions: </strong>This longitudinal study improves our knowledge of the factors influencing middle-aged and older individuals' OCU in Thailand.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1176"},"PeriodicalIF":2.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of sterilization on the cutting efficiency of two different rotary NiTi instruments (An In- vitro Study).","authors":"Merna Mamdouh Botros, Kariem Mostafa ElBatouty, Tariq Yehia Abdelrahman","doi":"10.1186/s12903-025-06534-w","DOIUrl":"10.1186/s12903-025-06534-w","url":null,"abstract":"<p><strong>Background: </strong>Dental rotary instruments can be applied under multiple canal conditions. This study assessed the performance of two batches of NiTi dental rotary files-Mani Jizai (Jz) and Dentsply ProTaper Next (PTN)-by evaluating their cutting efficiency.</p><p><strong>Methods: </strong>A total of 80 files (40 from each type), with 8x digital microscope magnification used for defect inspection, were tested half of which before and the other half after sterilization. The sample size was tested in extracted upper molars' distobuccal (DB) roots to assess cutting efficiency by volumetric changes showing removed dentin volume.</p><p><strong>Results: </strong>The Results indicated that the sterilized PTN files performed better at 5 mm, but no significant differences were noted at 10 mm between all file groups. At 15 mm, the performance of sterilized PTN files was inferior to that of non-sterilized Jz files.</p><p><strong>Conclusion: </strong>Sterilization and heat treatment affect file cutting efficiency by volumetric changes, especially at the coronal and apical one-thirds.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1173"},"PeriodicalIF":2.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Pica practices, anemia, and oral health outcomes: a systematic review.","authors":"Brenda A Z Abu, Abigail Morrissey, Yan Wu, Daniel A Castillo, Rachel Becker, TongTong Wu, Kevin Fiscella, Steven Gill, Jin Xiao","doi":"10.1186/s12903-025-06429-w","DOIUrl":"10.1186/s12903-025-06429-w","url":null,"abstract":"","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1183"},"PeriodicalIF":2.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quorum quenching by Est816: a novel approach to control Porphyromonas gingivalis pathogenicity.","authors":"Zelda Ziyi Zhao, Lifeng Guo, Xiangyang Li, Tianfan Cheng, Chun Hung Chu, Jing Zhang","doi":"10.1186/s12903-025-06563-5","DOIUrl":"10.1186/s12903-025-06563-5","url":null,"abstract":"<p><strong>Background: </strong>Porphyromonas gingivalis (P. gingivalis), a keystone pathogen in peri-implantitis, employs quorum sensing (QS) via N-acyl homoserine lactones (AHLs) to regulate biofilm formation and virulence. Quorum-quenching enzymes, such as the AHL-lactonase Est816, offer a promising therapeutic strategy to disrupt microbial pathogenicity. This study investigated the anti-biofilm, anti-virulence, immunomodulatory, biocompatibility, and osteogenic properties of Est816 against P. gingivalis, exploring its therapeutic potential for peri-implantitis management.</p><p><strong>Methods: </strong>P. gingivalis (ATCC 33277) was cultured on titanium discs and treated with Est816 (P. gingivalis + Est816). Biofilm morphology, biomass, viability, and kinetics were assessed using scanning electron microscopy (SEM), crystal violet staining, confocal laser scanning microscope (CLSM), and colony-forming unit (CFU) counting. Exopolysaccharide (EPS) production was quantified via phenol-sulfuric acid assay, while virulence gene expression was analyzed by RT-PCR. Cytotoxicity of Est816 on human oral keratinocytes (HOKs) was assessed using immunofluorescent microscopy. The immunodulatory impact of Est816 on P. gingivalis infected human periodontal ligament stem cells (PDLSCs) was assessed via ELISA and RT-PCR. Osteogenic differentiation of PDLSCs was examined by alizarin red staining.</p><p><strong>Results: </strong>Est816 treatment disrupted biofilm architecture (SEM), reducing biomass (crystal violet: 88% decrease, p < 0.001), viability (CLSM: live/dead ratio 0.3 vs. 5.7 control, p < 0.05), and CFU counts (2.8-log reduction, p < 0.001). EPS production decreased by 44% (p < 0.01), and virulence gene expression was significantly suppressed (rgpA: 80%, kgp: 76%, fimA: 73%, p < 0.01). Est816 exhibited no cytotoxicity toward HOKs and attenuated pro-inflammatory cytokine secretion in PDLSCs (TNF-α: 2.4-fold, IL-1β: 2.3-fold, IL-6: 11-fold, IL-8: 14-fold, reduction, p < 0.05). Furthermore, Est816 alone had no effect on the osteogenic differentiation of PDLSCs; however, it abolished the inhibitory effect of AHLs, significantly enhancing mineralized nodule formation by 1.4-fold (p < 0.001) compared to the AHL-treated control.</p><p><strong>Conclusion: </strong>Est816 exhibited anti-biofilm property, attenuated virulence release in P. gingivalis, and counteracted AHL-mediated suppression of osteoblast differentiation in PDLSCs, highlighting its dual therapeutic role in both pathogen inhibition and host tissue regeneration for peri-implantitis.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1178"},"PeriodicalIF":2.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of dental treatments under nitrous oxide-oxygen inhalation sedation in pediatric patients with dental anxiety: a 10-Year retrospective study.","authors":"Behrang Ghabchi, Özant Önçağ, Sevgi Arabulan, Aslı Aşık, İlhan Uzel","doi":"10.1186/s12903-025-06588-w","DOIUrl":"10.1186/s12903-025-06588-w","url":null,"abstract":"<p><strong>Background: </strong>This study assessed the use of nitrous oxide-oxygen (N₂O-O₂) inhalation sedation in pediatric dental treatments, focusing on patient demographics, general health status, and the types of procedures performed.</p><p><strong>Methods: </strong>This retrospective study analyzed clinical records of 96 pediatric patients (aged 4-12 years) treated at the Pediatric Dentistry Clinic, Ege University, School of Dentistry, under N₂O-O₂ inhalation sedation between 2010 and 2020. The study statistically examined archival data to analyze patient demographics, health status, adverse effects. success rates, and dental procedures performed.</p><p><strong>Results: </strong>In 96 pediatric patients (33 girls, 63 boys) with dental anxiety, 128 sedation applications were performed to conduct 162 dental treatments. The participants were categorized as ASA I and ASA II based on their overall health condition, and their ages spanned from 4 to 12 years. The patients treated under N₂O-O₂ inhalation sedation underwent 52 restorative fillings, 1 vital pulp treatment, 4 endodontic treatments, 103 tooth extractions, 1 impression for space maintainer, and 1 gingival surgery. None of the 128 sedation procedures resulted in reported adverse effects.</p><p><strong>Conclusion: </strong>Dental treatments under N₂O-O₂ inhalation sedation in pediatric dentistry are a safe method used for patients with dental anxiety. These procedures can facilitate the provision of appropriate treatments for uncooperative patients, ultimately leading to improved quality of life.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1171"},"PeriodicalIF":2.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating role of systemic inflammation on the association between periodontitis and gestational diabetes mellitus: a cross-sectional study.","authors":"Jing Cheng, Qi Jiang, Yang Liu, Shengdan Zhang, You Wang, Dai Lin, Bo Cheng","doi":"10.1186/s12903-025-06541-x","DOIUrl":"10.1186/s12903-025-06541-x","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to explore the relationship between periodontitis and gestational diabetes mellitus (GDM) and to ascertain the role of systemic inflammation in mediating this association.</p><p><strong>Methods: </strong>Data from 5,283 women of reproductive age ranging from 20 to 44 years were retrieved from the National Health and Nutrition Examination Survey (NHANES) III (1988-1994) and NHANES 2009-2014 cycles. The female participants were categorized into three groups: non-diabetes, DM, and GDM. Multivariate logistic and linear regression models were employed to assess the correlations between periodontal variables and diabetes status. Additionally, a mediation analysis was performed to explore the role of systemic inflammatory biomarkers.</p><p><strong>Results: </strong>Compared to non-periodontitis, women with periodontitis have a 1.68 times higher risk of having GDM (OR = 1.68, 95% CI: 1.14-2.50). Clinical attachment level (CAL), the continuous periodontal parameter, also presented a significant association with GDM risk (OR = 1.50, 95% CI: 1.25-1.81 per 1-mm increase). Linear regression analyses further revealed that hemoglobin A1c (HbA1c) levels were positively associated with periodontitis (Beta = 0.19, SE = 0.06, p < 0.01) and CAL (Beta = 0.06, SE = 0.03, p < 0.001), respectively. The association between periodontitis and GDM risk was found to be mediated by white blood cell count (WBC), monocyte count, and monocyte-lymphocyte ratio (MLR), with mediation proportions of 5.02%, 5.88%, and 5.20%, respectively. Similar mediation effects were observed for the CAL-GDM association.</p><p><strong>Conclusions: </strong>The present study indicated that periodontitis was associated with GDM among women of childbearing age, with systemic inflammation potentially serving as a partial mediator of this association.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1179"},"PeriodicalIF":2.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between complex root canal morphology of mandibular anteriors and distolingual roots in mandibular first molars in a Turkish population.","authors":"Özge Kurt, Elif Solakoğlu","doi":"10.1186/s12903-025-06515-z","DOIUrl":"10.1186/s12903-025-06515-z","url":null,"abstract":"<p><strong>Background: </strong>This study analyzes Cone Beam Computed Tomography (CBCT) images of mandibular anterior teeth (MATs) in the Turkish population to assess canal configurations, anatomical symmetry, and their correlation with distolingual roots (DLRs) in mandibular first molars (MFMs).</p><p><strong>Methods: </strong>In this retrospective study, CBCT images from 2000 patients were analyzed. A total of 12,000 mandibular teeth including six MATs and MFMs from each patient were evaluated using CBCT imaging. Images meeting inclusion criteria were categorized based on Vertucci's root canal morphology system. The data were classified by gender and symmetry patterns. The relationship between MAT root canal complexity and the presence of DLRs in MFMs was assessed.</p><p><strong>Results: </strong>Type I and Type III canal configurations were the most common in MATs. Complex canals appeared more often in females than in males. Among females, a small portion exhibited a unilateral group, while nearly half had a bilateral group. In males, about half showed a bilateral group, with no unilateral cases observed. More than half of MFMs had DLRs. Unilateral DLRs were seen in a notable number of females and a larger number of males. Bilateral DLRs were present in a smaller number of females and a slightly larger number of males. There was a clear link between DLRs and complex MAT canal configurations. Complications in bilateral MATs occurred more frequently in patients with bilateral DLRs.</p><p><strong>Conclusion: </strong>In the Turkish population, DLRs in MFMs are significantly associated with complex MATs canal configurations. CBCT imaging provides essential insights into root canal anatomy, aiding in the early detection of complex morphologies for optimal endodontic treatment.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1174"},"PeriodicalIF":2.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamins C and E alleviate the deleterious effects of electronic cigarettes on tongue muscles and nerves in rat model.","authors":"Yasmine M Tolba, Raghda A Abou Ayana, Dina A Nagui","doi":"10.1186/s12903-025-06523-z","DOIUrl":"10.1186/s12903-025-06523-z","url":null,"abstract":"<p><strong>Background: </strong>This study evaluated the ultrastructural effects of electronic cigarettes' (EC) exposure in rat lingual nerves and muscles and assessed the therapeutic roles of vitamins C, E, and their combination.</p><p><strong>Methods: </strong>Forty adult male albino rats were allocated into 5 groups.</p><p><strong>Control: </strong>injected saline intraperitoneally, EC group: injected EC-liquid containing nicotine at a dose of 0.75 mg/kg, EC + C group: injected with EC-liquid and then supplemented orally with vitamin C, EC + C group injected with EC-liquid and then supplemented orally with vitamin E, and EC + C&E group: injected with EC-liquid and then supplemented orally with a combination of both vitamins. Transmission electron microscopy (TEM) and oxidative stress biomarkers malondialdehyde (MDA), and superoxide dismutase (SOD) were used to assess tissue damage and antioxidant effects.</p><p><strong>Results: </strong>EC group showed disrupted myelin sheaths, abnormal mitochondria, elevated MDA, and reduced SOD activity, indicating oxidative damage. EC + C group showed muscular recovery but did not significantly improve oxidative markers (p > 0.05) when compared to EC group. EC + E and EC + C&E groups showed regular myelin sheaths, normal mitochondria, and significant improvements in MDA and SOD levels compared to the EC group (p < 0.01).</p><p><strong>Conclusions: </strong>Vitamin E alone or combined with vitamin C effectively mitigates EC-induced oxidative stress and ultrastructural damage in muscular and nerve tissues. Vitamin C alone offers insufficient protection, mostly supporting muscular recovery without significantly improving nerve integrity or oxidative status.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1184"},"PeriodicalIF":2.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}