BMC Oral Health最新文献

{"title":"In vivo biocompatibility of elderberry-enriched carboxymethyl chitosan in soft tissue and calvaria bone defects.","authors":"Bilge Cansu Uzun Saylan, Gizem Baysan, Osman Yılmaz, Candan Efeoglu, Serap Cilaker Micili, Nevin Ersoy, Mustafa Mahmut Baris, Kaan Orhan, Hasan Havitcioglu","doi":"10.1186/s12903-025-06991-3","DOIUrl":"10.1186/s12903-025-06991-3","url":null,"abstract":"","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1582"},"PeriodicalIF":3.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of artificial intelligence in orthodontic extraction treatment planning: a systematic review and meta analysis.","authors":"SeyedMehdi Ziaei, Dorsa Samani, Mohammadreza Behjati, Ava Ostovar Ravari, Yasaman Salimi, Sina Ahmadi, Sahar Rajaei, Farnoosh Alimohammadi, Soheil Raji, Niloofar Deravi, Haleh Fakhimi","doi":"10.1186/s12903-025-06880-9","DOIUrl":"10.1186/s12903-025-06880-9","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the diagnostic accuracy of artificial intelligence (AI) models in predicting dental extractions during orthodontic treatment planning.</p><p><strong>Method: </strong>A systematic review and meta-analysis were conducted following PRISMA guidelines and registered in PROSPERO (CRD42024582455). Comprehensive searches were performed across PubMed, Scopus, Web Of Science, and Google Scholar up to June 2, 2025. Eligible cross-sectional studies assessing AI-based models against clinical standards were included. Data on model performance were extracted and pooled using a random-effects model. Subgroup and meta-regression analyses were conducted to explore heterogeneity.</p><p><strong>Results: </strong>Seven cross-sectional studies from six countries with a combined sample of 6,261 patients were included. Pooled sensitivity and specificity of AI models were 70% (95% CI: 61-78) and 90% (95% CI: 87-92), respectively, though heterogeneity was high (I² = 96.7% and 93.7%). Convolutional neural networks (CNN)-based models (ResNet and VGG) demonstrated the highest diagnostic performance with no heterogeneity. Meta-regression showed that disease prevalence significantly influenced sensitivity (p = 0.050). Funnel plots revealed asymmetry, suggesting possible publication bias.</p><p><strong>Conclusion: </strong>AI models, particularly CNN-based models, show promising accuracy in predicting the need for orthodontic extractions. Therefore, they can be used to create predictive models for orthodontic extractions to increase accuracy. Due to the high heterogeneity, further large-scale studies are needed to support clinical implementation.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1576"},"PeriodicalIF":3.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review and standardized comparison of health-related quality-of-life instruments available for patients with oral cavity cancer and oropharyngeal cancer.","authors":"Naira Figueiredo Deana, Carolina Ulloa, Francisco Ceballos, Nilton Alves, Rodrigo Mariño, Wilfredo Alejandro González-Arriagada, Carlos Zaror","doi":"10.1186/s12903-025-06984-2","DOIUrl":"10.1186/s12903-025-06984-2","url":null,"abstract":"<p><strong>Background: </strong>To identify HRQoL instruments available for oral cavity cancer (OCC) or oropharyngeal cancer (OC) patients and to summarize the evidence on conceptual model measurement, psychometric and administration properties.</p><p><strong>Materials and methods: </strong>We searched MEDLINE, CENTRAL, EMBASE, and LILACS until April 2023. We included studies evaluating the concept model measurement, psychometric and administration properties of instruments measuring HRQoL in OCC or OC patients. Two researchers assessed each instrument independently, using the Evaluating Measures of Patient-Reported Outcomes (EMPRO) tool. We calculated the overall and seven attribute-specific scores (range 0-100) using the conceptual and measurement model, reliability, validity, responsiveness, interpretability, burden, and alternative forms.</p><p><strong>Results: </strong>We included seven instruments across 42 articles. The overall EMPRO score of these instruments varied between 84.1 and 29.3, with five questionnaires exceeding the threshold score of 50.0. The domains of conceptual and measurement model and interpretability performed best, while responsiveness exhibited the lowest performance.</p><p><strong>Conclusions: </strong>The findings support the use of EORTC QLQ-H&N43, EORTC QLQ-C30, and EORTC QLQ-OH15 as suitable HRQoL instruments for both cross-sectional or longitudinal studies to measure physical, symptomatic, psychological, or social impacts in patients with OCC or OC. FACT-H&N and UW-QoL were deemed appropriate for evaluating HRQoL in cross-sectional studies in these patients.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1584"},"PeriodicalIF":3.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of nomograms for ameloblastoma recurrence prediction: a multinational, two-center study from Seoul, South Korea and Wuhan, China.","authors":"Derong Zou, Hao Lin, Junxu Chen, Tianfu Wu, Hyung Jun Kim, Bing Liu","doi":"10.1186/s12903-025-06965-5","DOIUrl":"10.1186/s12903-025-06965-5","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to construct and validate region-specific nomograms to predict ameloblastoma recurrence and to investigate potential geographic differences in recurrence-related risk factors between South Korea and China.</p><p><strong>Materials and methods: </strong>A total of 816 patients with ameloblastoma treated between 2006 and 2023 were retrospectively analyzed from Yonsei University Dental Hospital (n = 372) and Hospital of Stomatology, Wuhan University (n = 444). Demographic, radiographic, and pathological variables were collected. Logistic regression analysis identified recurrence-associated predictors. Separate nomograms were developed and internally validated for each cohort. Model performance was evaluated using the area under the curve (AUC), calibration curves, and decision curve analysis.</p><p><strong>Results: </strong>The South Korean nomogram incorporated six variables, including pathological type, malignant transformation, surgical method, imaging type, tumor size, and cortical bone destruction (AUC = 0.757). The Chinese model incorporated eight predictors, including sex, root resorption, and number of involved teeth (AUC = 0.787). Calibration and decision curves indicated strong agreement between predicted and observed outcomes and favorable clinical applicability.</p><p><strong>Conclusions: </strong>Both nomograms demonstrated good predictive accuracy and highlighted regional differences in risk factors. These findings support the integration of multicenter data to enhance recurrence prediction in ameloblastoma.</p><p><strong>Clinical relevance: </strong>The developed tools can guide individualized treatment planning and long-term follow-up, aiding clinicians in early identification of high-risk patients and optimizing surgical strategies.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1579"},"PeriodicalIF":3.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel method to define personalized post-orthodontic treatment dental arch form.","authors":"Yingying Su, Jiachao Zhang, Hanyan Ma, Xu Zheng","doi":"10.1186/s12903-025-06993-1","DOIUrl":"10.1186/s12903-025-06993-1","url":null,"abstract":"<p><strong>Background: </strong>The dental arch is a fundamental aspect of orthodontic treatment and has considerable implications in planning and therapy. Since arch forms differ (e.g. tapered, ovoid, square), determination of posttreatment arch form should take each patient's dental arch features into account. This study aims to develop a method to predict optimal post-orthodontic treatment dental arch form.</p><p><strong>Methods: </strong>Mandibular dental casts of 55 patients who underwent non-extraction treatment and presented with functional occlusion according to functional occlusion criteria were selected. The casts were scanned and digitalized, 18 landmarks were collected and the spatial coordinates were utilized to compute tooth size and intermolar width. Several mathematical functions were then used to ensure a best-fitting mandibular arch form, including beta function, polynomial equations and polynomial combined with circle equations.</p><p><strong>Results: </strong>After applying several mathematical functions, we developed a mixed model made of two simple geometrical curves. The anterior segment of the dental arch was fitted with a circle and the posterior segment with a quartic curve; both could be calculated simply using tooth size.</p><p><strong>Conclusions: </strong>The present study presents a new approach to determine an individualized post-orthodontic treatment dental arch form, using the combined width of the lower teeth. The proposed method offers a simple and practical solution that can be easily implemented in clinical practice. These findings hold great promise for digital personalized treatment and the development of customized orthodontic appliances.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1587"},"PeriodicalIF":3.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving aspects of oral care in modern nursing: a systematic review.","authors":"Elham Rasoulian Barzoki, Somayeh Fallah, Samaneh Marofi, Mahla Talebi","doi":"10.1186/s12903-025-07000-3","DOIUrl":"10.1186/s12903-025-07000-3","url":null,"abstract":"<p><strong>Introduction: </strong>Oral care is a critical yet often neglected aspect of nursing, essential for preventing complications like ventilator-associated pneumonia and systemic inflammation. Despite its importance, nurses face challenges due to limited training, time constraints, and inconsistent protocols. The evolving role of nurses in oral care reflects broader healthcare shifts toward interprofessional and patient-centered models. This systematic review examines these dynamics to inform evidence-based improvements.</p><p><strong>Methods: </strong>Following PRISMA guidelines, this systematic review synthesized qualitative, quantitative, and mixed-methods studies from 2015 to 2025, sourced from PubMed, CINAHL, Scopus, Web of Science, Embase, and grey literature. Search terms targeted nurses' roles, perceptions, barriers, and interventions in oral care. Eligible studies involved registered nurses or students in healthcare settings, with data extracted on study characteristics, outcomes, and interventions. Quality was assessed using JBI and MMAT tools, and a narrative synthesis integrated findings via thematic analysis using NVivo.</p><p><strong>Results: </strong>From 2,347 records, 32 studies across 12 countries were included, covering ICUs (n = 12), general wards (n = 8), and nursing homes (n = 5), with sample sizes ranging from 7 to 1,576 participants. Key themes emerged: inadequate knowledge due to limited education, variable attitudes influenced by setting, inconsistent practices lacking standardized tools, and barriers like workload and resource shortages. Enablers included enhanced training, with over 80% of nurses in multiple studies seeking further education, patient empowerment, interdisciplinary collaboration, and policy support. Training programs, such as virtual reality simulations, improved knowledge and confidence, while resource availability enhanced practice quality.</p><p><strong>Conclusion: </strong>Nurses' effectiveness in oral care is hindered by educational gaps, systemic barriers, and inconsistent prioritization, but bolstered by targeted training and resources. These findings can guide nursing curricula and hospital policy reforms to prioritize oral care globally. Comprehensive nursing curricula, evidence-based protocols, and interdisciplinary collaboration are essential to elevate oral care as a core responsibility. Future research should focus on scalable interventions in diverse settings to enhance patient outcomes.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1585"},"PeriodicalIF":3.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tooth-to-white spot lesion YOLO: a novel model for white spot lesion detection.","authors":"Hau Man Chung, Jingjing Ke, Mengdan Zhang, Lixian Kong, Junming Zheng, Lusai Xiang","doi":"10.1186/s12903-025-06936-w","DOIUrl":"10.1186/s12903-025-06936-w","url":null,"abstract":"<p><strong>Background: </strong>To develop a new deep learning model for detecting white spot lesions (WSLs), which are commonly observed in patients undergoing orthodontic treatment, and assess its accuracy.</p><p><strong>Methods: </strong>A total of 653 intra-oral photographs of WSLs were collected and annotated. Our novel model, tooth-to-WSL You Only Look Once (TW-YOLO), and the original YOLOv5 model were fine-tuned and evaluated, with 457 photographs used for training; 130, for validation; and 66, for hold-out testing. Cohen's kappa coefficient between model prediction and orthodontist annotation was used as the primary evaluation metric, and mean average precision (mAP@0.5:0.95), average precision (mAP@0.5) and F1 score were also evaluated. The score-CAM technique was used for explainability analysis.</p><p><strong>Results: </strong>Cohen's kappa coefficient values were 0.76 and 0.62 for TW-YOLO and YOLOv5, respectively. The mAP@0.5 and mAP@0.5:0.95 were 0.78, 0.51 for TW-YOLO and 0.69, 0.45 for YOLOv5, respectively. Explainability analysis suggested that the TW-YOLO model could implicitly learn the distribution pattern of WSLs by shifting more attention toward these regions.</p><p><strong>Conclusion: </strong>Compared to original YOLO model, our novel TW-YOLO model demonstrated improved accuracy. Smaller proportion of small sized object and examine tooth enamel at original resolution contributed to this improvement.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1577"},"PeriodicalIF":3.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of composite consistency and pre-heating on cervical adaptation in class II restorations: a micro-CT evaluation.","authors":"Gülbike Demirel, Özgür Irmak, Arda Buyuksungur, Kaan Orhan, Ivo Krejci, Tissiana Bortolotto","doi":"10.1186/s12903-025-06976-2","DOIUrl":"10.1186/s12903-025-06976-2","url":null,"abstract":"<p><strong>Background: </strong>To compare the cervical adaptation of paste-like bulk-fill resin composites placed with either conventional or pre-heating insertion techniques to that of flowable bulk-fill resin composites.</p><p><strong>Methods: </strong>Six paste-like resin composites (one conventional, five bulk-fill) and five flowable resin composites (one conventional, four bulk-fill) were placed into Class II box-only cavities. Paste-like composites were placed with either conventional insertion or after pre-heating (68 °C). Flowable composites were placed only with the conventional insertion technique; no pre-heating was performed. After cavities were restored, specimens were subjected to thermal aging. Then, ammoniacal silver nitrate (AgNO₃) tracer was used followed by micro-computerized tomography scanning. AgNO₃ penetration volume was calculated. Data was analyzed with 2-way ANOVA followed by Tukey's multiple comparison test (α = 0.05).</p><p><strong>Results: </strong>Pre-heating improved the cervical adaptation of all composites compared to conventional placement (p < 0.05) except for the fiber-reinforced composite. All flowable resin composites showed higher AgNO₃ penetration than their paste-like pre-heated counterparts (p < 0.05). AgNO₃ penetration volume at the cervical margin was significantly lower when paste-like bulk-fill resin composites were pre-heated to 68 °C before they were placed into Class II box-only cavities.</p><p><strong>Conclusions: </strong>Pre-heating significantly enhanced the cervical adaptation of paste-like bulk-fill resin composites, offering superior marginal integrity compared to both their non-heated counterparts and flowable composites.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1578"},"PeriodicalIF":3.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bruxism in implant-supported rehabilitations: a narrative review of clinical complications and management strategies.","authors":"Elnaz Shafiee, Amin Nourizadeh","doi":"10.1186/s12903-025-07005-y","DOIUrl":"10.1186/s12903-025-07005-y","url":null,"abstract":"<p><strong>Background: </strong>Bruxism represents a significant risk factor for complications in implant-supported rehabilitations. Unlike natural teeth cushioned by periodontal ligament, the rigid osseointegrated connection transmits excessive bruxing forces directly to the implant-bone interface and prosthetic components.</p><p><strong>Objective: </strong>This narrative review synthesizes current knowledge regarding bruxism-related complications in implant-supported rehabilitations and evaluates available management strategies.</p><p><strong>Methods: </strong>A comprehensive narrative review was conducted using PubMed/MEDLINE, Embase, Web of Science, Scopus, Cochrane Library, and Science Direct databases covering publications from January 1990 to December 2024. Studies investigating bruxism's relationship with dental implant outcomes, clinical complications, and management strategies were included.</p><p><strong>Results: </strong>Systematic reviews demonstrate that bruxing patients have 2.2-4.7 fold increased implant failure risk compared to non-bruxing patients. Finite element analyses reveal that occlusal splints reduce stress concentration by 33-73% depending on load magnitude. Limited evidence exists regarding the association between bruxism and peri-implant bone loss. Technical complications include prosthetic component fractures, screw loosening, and framework failures. Management strategies include occlusal splint therapy, modified prosthetic designs, strategic implant placement, and comprehensive follow-up protocols.</p><p><strong>Conclusions: </strong>While bruxism significantly increases the risk of complications in implant-supported rehabilitations, successful outcomes are achievable through comprehensive management approaches. Evidence supports the effectiveness of occlusal splints in stress reduction and splinted prosthetic designs for optimal force distribution. However, the relationship between bruxism and implant complications remains complex, requiring standardized diagnostic criteria and evidence-based treatment protocols.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1586"},"PeriodicalIF":3.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the effects of calcium hydroxide-based, calcium silicate-based, and epoxy resin-based sealers on postoperative pain after a single session non-surgical endodontic retreatment: a randomized clinical trial.","authors":"Salih Düzgün, Haydar Albayrak, Hüseyin Sinan Topçuoğlu","doi":"10.1186/s12903-025-06961-9","DOIUrl":"10.1186/s12903-025-06961-9","url":null,"abstract":"<p><strong>Objectives: </strong>This randomized clinical trial aimed to evaluate the effect of calcium hydroxide-based, calcium silicate-based and epoxy resin-based root canal sealers on postoperative pain (PP) after a single session of non-surgical endodontic retreatment of the teeth with chronic apical periodontitis.</p><p><strong>Materials and methods: </strong>Ninety-six participants who had teeth with previously root canal treatment, asymptomatic, a single root and single canal, chronic apical periodontitis, were included in the study and then were randomly allocated to one of three experimental groups. (n = 32 per group).An endodontic specialist performed same retreatment protocols in a single visit. Participants were asked to rate the intensity of PP on a visual analogue scale at 6, 12, 24, and 48 h, and 3, 4,5, 6, and 7 days, and to mark whether they had taken analgesic (400 mg Ibuprofen) during the same periods after retreatment. All statistical analyses were performed using a software program (IBM SPSS Statistics, Version 22), and the significance level was set at P < 0.05.</p><p><strong>Results: </strong>There was no significant difference between the groups in PP and analgesic intake at any of the time intervals evaluated(P > 0.05).A strong positive correlation was observed at 48 h and 96 h when the correlation between PP and analgesic intake was evaluated regardless of the type of root canal sealer. PP level was associated with age, gender, Periapical Index (PAI) score, and jaw type.(P < 0 0.05).</p><p><strong>Conclusions: </strong>Epoxy resin, Calcium silicate, and calcium hydroxide-based root canal sealers resulted in statistically similar postoperative pain levels.</p><p><strong>Clinical significance: </strong>Each of the epoxy resin, calcium silicate, and calcium hydroxide-based root canal filling materials could be used safely in patients when considering PP.</p><p><strong>Trial registration: </strong>ClinicalTrial.gov, NCT06803277, record date: 2025-01-17, retrospectively registered.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1583"},"PeriodicalIF":3.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}