BMC Oral Health最新文献

{"title":"Management of deep carious lesions among Syrian dentists: a cross-sectional study.","authors":"Rashad Alghorani, Mhd Bahaa Aldin Alhaffar, Hussam Milly, Avijit Banerjee","doi":"10.1186/s12903-025-05834-5","DOIUrl":"10.1186/s12903-025-05834-5","url":null,"abstract":"<p><strong>Background: </strong>Deep carious lesions present significant challenges in dental practice, requiring effective management strategies to preserve tooth sensibility and function. This study aimed to assess Syrian dentists 'practices related to deep carious lesions and managing exposed pulps in teeth with reversible pulpitis in permanent teeth. It also examined the impact of dentists' experience and specialization on their choice of techniques and diagnostic tools.</p><p><strong>Methods: </strong>A cross-sectional study was conducted using a self-administered paper-based questionnaire distributed to dentists in Damascus. The questionnaire collected 1- demographic data, 2- clinical decisions before the start of the treatment, and 3- clinical decisions to treat deep carious lesions in different clinical cases and the management of exposed pulps. Data were analyzed to identify trends and differences in practices based on experience and specialization. Data were coded into excel and analyzed using SPSS V.25.</p><p><strong>Results: </strong>The study included responses from 252 dentists. The majority of dentists chose to take radiographs before treatment (69.4%), or do a sensibility test (70.6%). A strong preference for minimally invasive techniques was observed, such as partial caries removal to avoid pulp exposure (71.7%) and the use of hand excavators (53.2%). Dentists with more than 10 years of experience were more likely to work without rubber dam (< 0.001), while endodontists tended to apply rubber dam more than other clinicians (< 0.001). Experienced and specialist dentists were more likely to use rubber dam (p = 0.001) and perform sensibility tests (p = 0.000). The unique context of practicing in Syria, marked by conflict and political sanctions, significantly influenced decision-making of the biomaterials used, with the majority using calcium hydroxide (60.7%) and avoiding other materials, such as MTA and Biodentine, due to cost (31.5%) and availability (9.2%).</p><p><strong>Conclusions: </strong>This study documented the clinical decision among Syrian dentist before and during the treatment of deep carious lesions. Clinical decisions and practices are significantly affected by years of experience and whether the dentist is specialized or not. General dentists and other specialists were less likely to perform vital pulp therapies when pulp exposed in teeth with reversible pulpitis than endodontists. Complementary education of Syrian dentists in the domain of pulps exposed management appears necessary regarding current recommendations.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"440"},"PeriodicalIF":2.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of number and position of tooth loss and quality of life in the Chilean population: a cross-sectional study.","authors":"Andrés Celis Sersen, Jorge Celis-Dooner, Juan Pablo Vargas Buratovic, Claudio Carrasco Mococain, Beatriz Mellado Torres, Francisco Moreno Ferrer, Elizabeth López Tagle, Duniel Ortuno Borroto","doi":"10.1186/s12903-025-05822-9","DOIUrl":"10.1186/s12903-025-05822-9","url":null,"abstract":"<p><strong>Background: </strong>Multiple studies have demonstrated the association between Quality of Life (QoL) and the prevalence of caries, periodontitis, and tooth loss. However, the role of the position and location of tooth loss in impacting QoL remains unclear.</p><p><strong>Aim: </strong>To evaluate the association of tooth loss, including anterior losses, with Health-Related Quality of Life (HRQoL) and Oral Health-Related Quality of Life (OHRQoL) in Chileans aged 15 years and older who participated in the ENS 2016-2017.</p><p><strong>Methods: </strong>In this cross-sectional study we included 5473 individuals enrolled in the last Chilean National Health Survey (ENS 2016-2017). HRQoL was measured using the EQ-5D questionnaire, while OHRQoL was assessed through a general question (GQ/ENS) and five specific questions (SQ/ENS). An analysis of variance test was performed to determine how difference or variation in the number(s) of teeth affected their HRQoL. Odds ratios with corresponding 95% confidence intervals were calculated using multinomial logistic regression to determine how and to what degree anterior tooth loss was associated both with HRQOL and OHRQOL in the study sample.</p><p><strong>Results: </strong>The number of remaining teeth was significantly higher in the 'No problems' group across all EQ-5D dimensions, except Anxiety/Depression. The largest difference was in Self-care, where 'No problems' had a mean of 20.18 compared to 6.43 teeth in the 'Problematic' group. Anxiety/Depression showed higher odds of 'Some problems' with upper anterior tooth loss, while 'Usual Activities' showed higher odds of 'problematic' with lower anterior tooth loss. Participants with an 'Excellent' OHRQoL perception had a mean of 24.32 teeth. Also, upper and lower anterior tooth loss increased the odds of OHRQoL self-perception.</p><p><strong>Conclusions: </strong>Tooth loss was associated with lower HRQoL and OHRQoL in some groups, with more remaining teeth associated with better outcomes, while anterior tooth loss was- linked to worse self-perceived oral health.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"447"},"PeriodicalIF":2.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eating behaviors, oral health care knowledge, and oral hygiene practices among residents in Fujian province, China: a cross-sectional study.","authors":"Mei-Ling Zheng, Fa Chen, Hao Yu, Chang-Yuan Zhang","doi":"10.1186/s12903-025-05747-3","DOIUrl":"10.1186/s12903-025-05747-3","url":null,"abstract":"<p><strong>Background: </strong>There is little literature that focuses on eating behaviors, oral health care knowledge and oral hygiene habits at the same time. People's oral health is affected by a variety of factors. This study investigated the eating behaviors, oral health care knowledge, and oral hygiene practices among residents of Fujian province, China, with different gender, age, and educational attainment.</p><p><strong>Methods: </strong>A self-administered questionnaire was designed and distributed through the online questionnaire platform, Questionnaire Star. After excluding unqualified responses (due to excessively short completion time, conflicting answers, etc.), an Excel database was constructed. Frequency counts (composition ratio) were used to characterize data distribution, and the chi-square test was used to compare self-reported oral health, eating behaviors, oral health care knowledge, and oral hygiene practices across different age, gender, and educational attainment of respondents. Data were analyzed using IBM SPSS (version 26.0), and differences were considered statistically significant at P < 0.05.</p><p><strong>Results: </strong>A total of 10,480 individuals completed the online questionnaire, with 8,254 questionnaires deemed valid, yielding a validity rate of 78.76%. Significant differences were observed in various aspects of eating behaviors among respondents of different age, gender, and educational attainment (P < 0.001), except for the consumption of fruit juice and hard foods. There was a significant difference in self-reported oral health status among respondents by age and education (P ≤ 0.001), while the difference by gender was not significant (P = 0.303). The respondents displayed inadequate oral health care knowledge, with significant disparities among respondents of different age, gender, and educational attainment (P < 0.05). There were also significant differences in oral hygiene practices among respondents of different age, gender, and educational attainment (P < 0.05).</p><p><strong>Conclusions: </strong>Eating behaviors, oral health care knowledge and oral hygiene practices of Fujian residents were related to age, gender and education attainment. Educational attainment was an important factor influencing the eating behaviors, oral health knowledge and oral hygiene practices of the population. Local residents' knowledge of oral health care was generally insufficient.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"446"},"PeriodicalIF":2.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing trends in oral mucosal diseases in China (2016-2024): a cross-sectional study of 316,166 patients with focus on COVID-19 impact and use of chinese patent medicines.","authors":"Peiru Zhou, Xu Zhang, Yifan Chen, Jiakun Fang, Yanhong Meng, Furong Yang, Pan Wei, Hong Hua","doi":"10.1186/s12903-025-05797-7","DOIUrl":"10.1186/s12903-025-05797-7","url":null,"abstract":"<p><strong>Background: </strong>Oral mucosal health is a critical component of overall oral health and impacts an individual's quality of life. Despite variations in prevalence rates of oral mucosal diseases across regions, previous studies often involved small sample sizes with insufficient data analysis. This study addresses the gap by providing a comprehensive analysis of the changing spectrum of oral mucosal diseases in China, with a focus on the impact of COVID-19. It also explores trends in the use of Chinese patent medicines (CPMs) for treatment.</p><p><strong>Methods: </strong>This retrospective, cross-sectional study included 316,166 patients from the Department of Oral Medicine at Peking University School and Hospital of Stomatology between 2016 and 2024. Data on patient demographics, chief complaints, diagnoses, and the use of CPMs were collected and analyzed. Statistical comparisons were made using t-tests and chi-square tests, with significance set at P < 0.05.</p><p><strong>Results: </strong>The average patient age was 49.42 ± 17.92 years, and women were significantly overrepresented (male/female ratio: 0.59). The most frequent diagnoses were oral lichen planus and recurrent aphthous stomatitis, accounting for the top two positions each year. The study found significant differences in disease patterns among age groups, with oral potentially malignant disorders like oral lichen planus becoming more prevalent in older populations. CPMs were used by 52.29% of patients, with similar proportions using topical and systemic treatments. During the COVID-19 pandemic (2020-2022), the number of patients dropped significantly, and an increased prevalence of burning mouth syndrome and oral candidiasis was observed.</p><p><strong>Conclusion: </strong>This study offers the largest amount of valuable epidemiological data on the management of oral mucosal diseases to date in China, underscoring the need for targeted health resource allocation. An important trend was the greater predilection for females and middle-aged and elderly populations. The top three diseases in terms of number of patients were oral lichen planus, recurrent aphthous stomatitis, and oral candidiasis. The treatment data indicated widespread use of CPMs for oral mucosal diseases. The COVID-19 pandemic was associated with a significant decrease in the number of total patients and was also characterized by an increase in the proportion of patients with diseases that have psychosomatic associations. The impact of the COVID-19 pandemic and the widespread use of CPMs warrant further investigation in future studies to ensure evidence-based medical practices.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"444"},"PeriodicalIF":2.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of low-level laser on proliferation, angiogenic and dentinogenic differentiation of human dental pulp stem cells.","authors":"Fatemeh Rezaei, Shahrzad Shakoori, Mahta Fazlyab, Ehsan Esnaashari, Sohrab Tour Savadkouhi","doi":"10.1186/s12903-025-05656-5","DOIUrl":"10.1186/s12903-025-05656-5","url":null,"abstract":"<p><strong>Background: </strong>The aim was to evaluate the effect of single and double doses of low-level laser irradiation on proliferation of human dental pulp stem cells (DPSC) and expression of vascular endothelial growth factor (VEGF) and dentine sialoprotein (DSP).</p><p><strong>Methods: </strong>In this experimental in vitro study, after confirming the stemness of DPSCs, the cells were cultured in Dulbecco's Modified Eagle Medium (DMEM) for MTT assay and VEGF-ELISA and osteogenic medium for DSP-ELISA. The wells containing DPSCs were divided into three main groups and 9 subgroups (n = 7). In groups with single low-level laser, 660-nm diode laser was irradiated at 100 mW and 3 J/cm² energy density for 15 s. In groups with double doses of low-level laser the second identical irradiation was after 48 h. The MTT-assay and ELISA for DSP/VEGF (dentinogenic/angiogenic differentiation) were performed at 1, 7 and 14 days post irradiation. Using the SPSS software 20 (SPSS, Chicago, Ill, USA) with 95% confidence interval (P = 0.05), a two-way ANOVA test with Tukey's post hoc test was used for the effect of LLLI on VEGF and DSP. The One-Way ANOVA was used for of cell proliferation.</p><p><strong>Results: </strong>Higher proliferation rate in both single and double low-level laser was reported. The difference was statistically significant for double doses of low-level laser (P = 0.001, P = 0.020 and P = 0.000 for 1, 7 and 14 days, respectively). Also after one, 7 and 14 days, cells in significant increase in DSP (P > 0.05) and VEGF (P > 0.05) was observed that was significantly higher for double doses of low-level laser.</p><p><strong>Conclusions: </strong>Low level laser enhanced the mitochondrial activity and proliferation of DPSCs. Increased production of DSP/VEGF indicates dentinogenic/angiogenic activity.</p><p><strong>Clinical relevance: </strong>Low level laser increases the proliferation of DPSCs, elevates the production of VEGF (which means better angiogenesis in regenerative treatments) and increases the production of DSP (which means better dentinogenesis in vital pulp treatments).</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"441"},"PeriodicalIF":2.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications of invasive oral procedures in patients with immune-mediated inflammatory disorders treated with biological and conventional disease-modifying antirheumatic drugs or glucocorticoids: a scoping review of the literature.","authors":"Loredana Radoi, Mohamed Kadri, Marjolaine Gosset","doi":"10.1186/s12903-024-05414-z","DOIUrl":"10.1186/s12903-024-05414-z","url":null,"abstract":"<p><strong>Objectives: </strong>By a scoping review, to evaluate whether patients with immune-mediated inflammatory disorders (IMIDs) treated with biological and conventional disease-modifying antirheumatic drugs (b/cDMARDs) and/or glucocorticoids (GCs) experience complications after invasive oral procedures.</p><p><strong>Materials and methods: </strong>Primary search was conducted on PubMed/MEDLINE database, Google Scholar, Embase and Web of Science up to December 31, 2023. The PICO question was \"Does a patient with IMIDs and treated with b/cDMARDs in mono/bi or combination therapies have delayed oral wound healing or infectious complications after an invasive oral procedure?\". To be included, references had to be primary studies written in English or French. Qualitative assessment was performed.</p><p><strong>Results: </strong>From 1,494 initial articles, 59 full-text articles were selected, including 47 case reports and case series, 7 comparative non-randomized studies, 1 randomized clinical trial, 2 case-case studies, 1 case-control study, and 1 prospective cohort study. Most reports involved patients with rheumatoid arthritis on methotrexate and/or anti-TNF. Complications (medication-related osteonecrosis of the jaw, delayed healing, local infection) occurred predominantly after tooth extractions, particularly affecting women, patients over 50 with bisphosphonate use, unhealthy lifestyle habits, or diabetes. They were generally managed with prolonged antibiotic and antiseptic courses, and surgical interventions.</p><p><strong>Conclusions: </strong>Local infectious complication or jaw osteonecrosis could occur post-invasive procedures, especially tooth extractions, in IMIDs patients on b/cDMARDs and/or GCs, often in patients with comorbidities and/or concurrent medications such as bone-modifying drugs.</p><p><strong>Clinical relevance: </strong>It is essential for dentists to be alert to the existence of local or focal infectious complications after tooth extraction in patients with IMIDs on immunosuppressive therapy.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"442"},"PeriodicalIF":2.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do I-PRF adjuvant injections in TMJ arthrocentesis have a cumulative physiological effect? A retrospective cohort study.","authors":"Tahsin Tepecik, Mert Zöngör, Ecem Gedik","doi":"10.1186/s12903-025-05824-7","DOIUrl":"10.1186/s12903-025-05824-7","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to compare the therapeutic outcomes of single versus multiple injectable platelet-rich fibrin (i-PRF) injections after arthrocentesis in patients with temporomandibular joint osteoarthritis (TMJ-OA). The objective was to evaluate and compare TMJ pain and mobility at the 1st, 6th, and 12th months postoperatively.</p><p><strong>Methods: </strong>This retrospective cohort study included 85 female patients (age: 31-73 years, mean ± sd: 54.9 ± 8.8) who underwent arthrocentesis with i-PRF injections from June 2018 to November 2021, diagnosed with osteoarthritis based on the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD). Patients had no prior use of occlusal splint. During follow-up visits, pain was evaluated with a visual analog scale (pVAS) during function and maximum interincisal opening (MIO) was measured to assess jaw mobility. The study included patient follow-up records at four time points: preoperative (T0), 1 month postoperative (T1), 6 months postoperative (T2), and 12 months postoperative (T3). The primary outcome variable was pVAS at T3, secondary outcome variables were pVAS at T1 and T2, and MIO at T1, T2, and T3.</p><p><strong>Results: </strong>No significant differences were found in joint pain or mobility between groups at follow-ups (> 0.05).</p><p><strong>Conclusions: </strong>Both groups showed similar outcomes in terms of pain and mobility over a 12-month period. Increasing the frequency of i-PRF injections does not appear to have an impact on therapeutic outcomes in patients with TMJOA. Given the retrospective design of this study, it is important to evaluate the results with caution.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"445"},"PeriodicalIF":2.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of oxymetazoline-based nasal solutions to remove bacteria-blood debris and eradicate Rothia dentocariosa: an artificial cavity model study.","authors":"Dhiraj Kumar, Morgan Pride, Kaushik Mukherjee, Gaurav Jain, Isha Mutreja, Robert S Jones","doi":"10.1186/s12903-025-05791-z","DOIUrl":"10.1186/s12903-025-05791-z","url":null,"abstract":"<p><strong>Background: </strong>This study evaluated the antibacterial properties of a potential pulpal medicament, a nasal solution with oxymetazoline (NS-OXY, 0.05%), against a dentinal caries pathogen.</p><p><strong>Methods: </strong>Using a disc diffusion susceptibility test (n = 6), Rothia dentocariosa was grown on brain-heart infusion (BHI) agar plates and exposed to OXY (0.05%), benzalkonium chloride (BKC-0.025%), OXY-NS (with OXY-0.05% and BKC), ferric sulfate (20%; ViscoStat), and distilled water (DI). This was followed by exposure of an artificial dental caries model with sheep blood to simulate the clinical pulpotomy procedure. An antibacterial broth inhibition test was conducted by adding the test samples in BHI broth at 37 ± 0.5 °C in an aerobic chamber.</p><p><strong>Results: </strong>In the disc diffusion test, NS-OXY and BKC had the largest zone of inhibition (ZOI) measuring 14.42 mm (± 1.62) and 18.92 mm (± 4.14) respectively, indicating antibacterial activity. Ferric sulfate demonstrated a smaller ZOI, while OXY alone had no ZOI. The antibacterial broth test showed antibacterial effects with stable OD and pH levels for test samples containing BKC (0.025%) and diluted NS-OXY (0.01%) for up to 20 h. DI- and OXY-treated samples showed an increase in OD, indicating an increase in bacterial count and a concurrent drop in pH. BKC treatment statistically (P < 0.05) reduced polyP extracts, which may contribute to blood clot formation. NS-OXY demonstrated antibacterial properties, likely due to the addition of BKC to Rothia dentocariosa. NS-OXY showed concentration dependent biocompatibility with dental pulp stem cells while FS was cytotoxic at the same dilution.</p><p><strong>Conclusion: </strong>These antimicrobial properties, together with OXY's hemostatic effects, suggest the potential off-label use of NS-OXY during a pulpotomy procedure in primary and permanent teeth. This study provides support for potential future clinical trials of repurposing FDA-approved drugs consisting of oxymetazoline and benzalkonium chloride for dental and other similar applications.</p><p><strong>Featured application: </strong>An over-the-counter nasal solution containing oxymetazoline has the potential to be used off-label to manage surgical bleeding from dental pulp exposures and provide antimicrobial properties against Rothia dentocariosa, a model gram-positive bacteria associated with deep dentinal caries.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"448"},"PeriodicalIF":2.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of Rsk2 on TNFα-mediated bone loss in the TMJ and craniofacial skeleton.","authors":"Gina Marie Georgi, Frédéric Bachmann, Julia Luther, Anja Derer, Patrick Heimel, Stefan Tangl, Bärbel Kahl-Nieke, Aaron LeBlanc, Jill Helms, Georg Schett, Christian Hirsch, Reinhard Gruber, Michael Amling, Thorsten Schinke, Till Koehne, Julian Petersen","doi":"10.1186/s12903-025-05779-9","DOIUrl":"10.1186/s12903-025-05779-9","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to investigate the impact of the pro-osteoblastogenic ERK-activated ribosomal S6 kinase (Rsk2) on Tumor necrosis factor (TNF)α-induced bone loss in the craniofacial system, focusing on its role in rheumatoid arthritis (RA). The objective is to understand whether Rsk2, previously shown to have protective effects in long bones against TNFα-induced bone resorption, exhibits similar effects in the craniofacial region.</p><p><strong>Materials: </strong>, and Methods. The study compares mice with TNFα overexpression, Rsk2 knockout mice, and a combination of TNFα, and Rsk2 knockout mice using detailed micro-computed tomography coupled with landmark based morphometric analysis, and classical histology. The overall skull morphology, mandible shape, and the temporomandibular joint were examined. Additionally, histological sections were utilized to examine the synovial membrane.</p><p><strong>Results: </strong>Combining TNFα, and Rsk2 deficiency does not further alter overall skull shape compared to TNFα alone. TNFα overexpression shortens the mandibular ramus, exacerbated by Rsk2 absence. Micro-computed tomography (µCT) reveals significant temporomandibular joint damage from TNFα, independent of Rsk2. However, histological sections show increased synovial membrane thickness with TNFα, heightened in the absence of Rsk2.</p><p><strong>Conclusions: </strong>Rsk2 mitigates TNFα-induced effects on mandibular ramus length in the craniofacial system but has limited impact on the temporomandibular joint, except for synovial membrane thickness. Overall, Rsk2 demonstrates a weaker preventive effect on TNFα-induced craniofacial bone loss compared to its established role in the appendicular skeleton.</p><p><strong>Clinical relevance: </strong>This study highlights regional differences in Rsk2's protective mechanisms, emphasizing the need for further exploration of the underlying mechanisms for these disparities. Understanding these regional differences can be crucial for the development of targeted therapeutic interventions.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"435"},"PeriodicalIF":2.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D modelling and x-ray depth analysis map of the pulp with computer software via digital periapical radiography and cone beam computed tomography.","authors":"Turgut Felek, Samed Satir, Selale Ozel, H Kursat Celik","doi":"10.1186/s12903-025-05801-0","DOIUrl":"10.1186/s12903-025-05801-0","url":null,"abstract":"<p><strong>Objective: </strong>Periapical radiographs (PAR) offer information about the pulp and periodontal health of teeth. However, intraoral radiographs are insufficient for diagnosing buccolingual anomalies and variations such as bifid canals due to their two-dimensional nature. Cone beam computed tomography (CBCT) is the gold standard for 3D imaging in the clinic but requires additional radiation. The aim of this study was to create a software (XPAR) which obtains x-ray depth analysis and 3D modelling of the pulps of single-rooted teeth by converting the grey values in the original radiographs into numerical data.</p><p><strong>Materials and methods: </strong>Two single-rooted teeth were included in the experimental part of the study. Chicken fibula bone was preferred for alveolar bone simulation because it could simulate cortical and trabecular structures due to similarity. A total of four images (60kVp & 70kVp; single alveolar bone & double alveolar bone) were obtained. The aim of this experimental part is to test the repeatability and realism of the algorithm to be created for pulp modelling. Retrospectively, 31 single-rooted teeth with both periapical radiography and cone-beam computed tomography imaging were included in the retrospective part of the study. According to XPAR, depth increase areas were interpreted as root resorption and accessory canal. Depth decrease areas were evaluated as the transformation of the pulp from an elliptical to an oval form, pulp stone, bifid canal formation and the presence of thick alveolar bone. The diagnostic accuracy of XPAR application on pathological and morphological changes was evaluated by comparing the obtained results with CBCT.</p><p><strong>Results: </strong>80% of the analyses diagnosed as bifurcation by XPAR application were supported by CBCT. This rate decreased to 27% in the diagnosis of transitions from elliptical to oval form. A total of 5 and 19 linear formations observed in the form of depth decrease and increase, respectively, were accepted as image errors in XPAR.</p><p><strong>Conclusion: </strong>Buccolingual bifid canal formations and pulp obliterations can be diagnosed with a rate of nearly 50% with the depth decrease finding obtained in XPAR application. Imaging errors caused by deformed detectors are typically observed as linear formations.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"439"},"PeriodicalIF":2.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}