BMC Oral Health最新文献

{"title":"Adults' dental caries burden through the DMFT index: Tanzanian national pathfinder survey.","authors":"Kasusu Nyamuryekung'e, Hawa Mbawalla, Matilda Mlangwa, Joyce Masalu","doi":"10.1186/s12903-025-06233-6","DOIUrl":"https://doi.org/10.1186/s12903-025-06233-6","url":null,"abstract":"<p><strong>Background: </strong>Dental caries remains the most prevalent chronic disease globally. The DMFT (Decayed, Missing, and Filled Teeth) index is a key metric in oral epidemiology to quantify the prevalence and severity of dental caries. This study aims to assess the dental caries burden among adults in mainland Tanzania using the DMFT index.</p><p><strong>Methods: </strong>A national pathfinder survey was conducted using a cross-sectional design across 14 districts in 13 regions of mainland Tanzania. Site selection followed the World Health Organization's (WHO) basic oral health survey methods, employing a modified stratified-cluster sampling approach. Adult participants completed electronic questionnaires prior to clinical dental examinations. Questionnaires gathered sociodemographic data, self-rated dentition status, tooth brushing practices, whereas clinical dental examination assessed dental caries status using the DMFT criteria. All data collection and dental examinations adhered to WHO standard criteria. Data were analysed using SPSS version 23. Frequencies were calculated to determine the proportions of participants' mean DMFT components. Bivariate associations were analysed using Mann Whitney U-test and Kruskal Wallis to compare DMFT components with sociodemographic characteristics and self-rated dentition status, whereas logistic regression was utilised for multivariate analysis.</p><p><strong>Results: </strong>The survey included 1,386 participants aged 30-34, 35-44, and 50+, with 713 females (51.4%). Nearly half of the participants (49.1%) were aged 50 years or older. The mean DMFT score was 4.63 (SD 5.4), with 76.6% experiencing dental caries. The Missing teeth component accounted for the largest portion of the mean DMFT (52.4%), followed by the Decayed teeth component (45.8%). Only 3.5% of participants with dental caries had tooth fillings. Higher median DMFT scores were observed among females, participants aged 50 or more, with lowest education levels and poor self-rated dentition status. Increased DMFT scores were linked to brushing less than once daily (p < 0.05) and not using a toothbrush daily (p < 0.01).</p><p><strong>Conclusion: </strong>The high dental caries prevalence (76.6%) and sociodemographic disparities highlight the need for an integrated approach combining preventive measures, oral health promotion and improved access to dental services to address this challenge effectively in Tanzania.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"998"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between individuals with unilateral and bilateral carotid artery calcifications and periodontal disease: a cross-sectional study.","authors":"Irem Melike Inan, Berrin Unsal, Sila Cagri Isler, Mujgan Firincioglulari, Dursun Valiyeva, Nurdan Ozmeric","doi":"10.1186/s12903-025-06272-z","DOIUrl":"https://doi.org/10.1186/s12903-025-06272-z","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the association between unilateral and bilateral carotid artery calcifications (CAC) and periodontal disease severity using panoramic radiographs, and assessed the influence of systemic risk factors such as hypertension, diabetes, and smoking.</p><p><strong>Methods: </strong>A retrospective cross-sectional study analyzed 116 radiographs from 87 females and 29 males with CAC. CAC was identified as radiopaque lesions near the C3-C4 intervertebral space. Participants were categorized into unilateral or bilateral CAC groups. Demographic data, medical histories, and periodontal parameters (plaque index, gingival index (GI), bleeding on probing, probing depth (PD), and clinical attachment loss) were recorded. Participants were classified as healthy, gingivitis, periodontitis stage I-II, or stage III-IV. Binomial logistic regression and independent samples t-tests were used.</p><p><strong>Results: </strong>Age and gender were not significantly associated with the type of CAC (p > 0.05). Only PD showed a significant association: an increase in PD was linked to higher odds of unilateral CAC and lower odds of bilateral CAC (p < 0.05). Smoking, diabetes, and hypertension were not significantly associated with the type of CAC (p > 0.05). Unilateral CAC was linked to higher GI, PD, and stage III-IV periodontitis, while bilateral CAC was more common in stage I-II (p < 0.05).</p><p><strong>Conclusion: </strong>The findings suggest a differential association between the severity of periodontitis and the type of CAC. Unilateral CAC may be more strongly linked to advanced periodontal inflammation, possibly reflecting an earlier, inflammation-dominant phase of atherosclerosis. Due to the cross-sectional design and use of panoramic radiographs, causal inferences cannot be drawn. Further longitudinal studies using advanced imaging techniques are needed.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1043"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical effects of clear aligners with different distal coverage designs combined with Class II elastic traction for maxillary first molar distalization: a finite element study.","authors":"Yiyan Zhang, Peiyan Wang, Chunmiao Jiang, Yi Liu, Xiangyu Ma, Yang Liu, Cunhui Fan","doi":"10.1186/s12903-025-06421-4","DOIUrl":"https://doi.org/10.1186/s12903-025-06421-4","url":null,"abstract":"<p><strong>Background: </strong>The sequential distalization of teeth may affect the final efficacy of molar distalization in clear aligner treatment (CAT), necessitating additional anchorage protection for distalized posterior teeth. This study aimed to examine the anchorage protection effects of a distal uncoverage clear aligner (DUCA) and Class II elastic traction on the distalized second molar during maxillary first molar distalization.</p><p><strong>Materials and methods: </strong>Finite element models of maxillary first molar distalization in CAT were constructed. Two different designs of CAs-a distal coverage aligner (DCA) and a DUCA-were utilized for maxillary first molar distalization after the second molar had been distalized by 2 mm. The force value of Class II elastic traction was set to 0, 1, 2, and 3 N. The displacement of the maxillary teeth and CAs was recorded.</p><p><strong>Results: </strong>Significant biomechanical differences were observed between DCA and DUCA. The initial closure of the space between the first and second molars in the DUCA group was mostly due to the first molar distalization. In comparison to DCA, DUCA exhibited less mesial displacement of the second molar and greater anterior anchorage loss. The anchorage loss reduction of the canines caused by Class II traction was the most pronounced, whereas the impact on the second molar was minimal.</p><p><strong>Conclusion: </strong>During first molar distalization in CAT, the anchorage protection effect of Class II elastic traction on the distalized second molar was limited. The utilization of a DUCA can effectively mitigate anchorage loss of second molar. Simultaneously, it is crucial to apply a greater Class II traction force to protect the anterior anchorage.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1033"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CBCT based investigation of furcation groove's prevalence, depth, length and associated dentin thickness in Maxillary First Permanent Premolars in Saudi Sub-population.","authors":"Safia S Shaikh, Muhammad Qasim Javed, Ahmed Ali, Zaina Ahmad, Khawlah Almohimeed, Ayman M Abulhamael, Ra'fat I Farah","doi":"10.1186/s12903-025-06364-w","DOIUrl":"https://doi.org/10.1186/s12903-025-06364-w","url":null,"abstract":"<p><strong>Background: </strong>The study aimed to investigate the furcation groove's (FG) prevalence, depth, length and associated dentin thickness (DT) in Maxillary First Permanent Premolars (MFPM's) in Saudi Sub-population.</p><p><strong>Methods: </strong>The study was a cross-sectional study, conducted at Qassim University, KSA, on 156 CBCT images. The presence of FG, its length, depth, and associated DT at the deepest point were recorded. Measurements were performed independently by two calibrated examiners. Statistical analysis was conducted using SPSS 26, with chi-square tests applied to assess gender- and quadrant-wise differences. The significance level for this study was set to be p < 0.05.</p><p><strong>Results: </strong>Among the studied MFPMs, 71% exhibited FGs on the palatal facet of the buccal root. The mean FG length was 4.16 mm, mean FG depth was 0.56 mm, and mean DT at the deepest point was 0.82 mm. No significant differences were found in FG prevalence based on gender or quadrant. Most grooves were located at the furcation level (75.8%), while the remaining were found below (16.7%) or before (7.5%) the furcation. Correlation analysis revealed a weak negative association between groove depth and dentin thickness (ρ = -0.180, p = 0.049). Multivariable ordinal regression identified male gender as the primary predictor of higher dentin thickness risk categories (OR = 5.12, p < 0.001), while groove morphometric parameters were not significant predictors.</p><p><strong>Conclusions: </strong>The high prevalence of FG in MFPMs and its significant association with reduced DT highlight its clinical importance. These anatomical features increase the risk of complications during endodontic treatment (ET), including strip perforations and vertical root fractures. In order to identify at-risk areas, preoperative CBCT evaluation is essential as this allows for modified treatment strategies to preserve root integrity and improve ET outcomes.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1030"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative assessment of biocompatibility of various fluoride agents in cell culture.","authors":"Bengi Aydınel, Çağla Kayabaşı, Dilşah Çoğulu, Cumhur Gündüz","doi":"10.1186/s12903-025-06496-z","DOIUrl":"https://doi.org/10.1186/s12903-025-06496-z","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study aimed to evaluate the biocompatibility of various fluoride agents using L929 fibroblast and human gingival fibroblast (HGF) cell cultures.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;Five different fluoride agents were included in the study; 1.23% Acidulated Phosphate Fluoride (APF) gel (Sultan Health Care, Engle Wood, USA), 2% Sodium Fluoride (NaF) gel (Sultan Health Care, Engle Wood, USA), 1% Titanium Tetrafluoride (TiF₄) solution (Sigma-Aldrich&lt;sup&gt;®&lt;/sup&gt; Chemie GmbH, Steinheim, Germany), 38% Silver Diamine Fluoride (SDF) solution (Saforide&lt;sup&gt;®&lt;/sup&gt;-J. Morita; Toyo Seiyaku Kasei Ltd/Osaka-Japan), and 5% NaF varnish (Duraphat&lt;sup&gt;®&lt;/sup&gt;, Colgate Oral Pharmaceuticals, New York, NY, USA). Cytotoxicity was evaluated using the real-time xCELLigence system, while apoptotic activity was determined through Annexin V/PI and TUNEL assays. Genotoxicity was assessed using the micronucleus test. The expression levels of the pro-apoptotic marker BAX and the anti-apoptotic marker BCL-2 were quantified using real-time PCR. All experiments were performed in triplicate and independently repeated to ensure reproducibility, with data analyzed using non-linear regression for IC₅₀ determination, one-way ANOVA with Tukey's post hoc test for group comparisons, and chi-square or Fisher's Exact tests for categorical variables (SPSS 25.0); statistical significance was set at p &lt; 0.05.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;NaF gel exhibited the lowest cytotoxicity in L929 fibroblast cell line, while APF gel demonstrated the least cytotoxicity in HGF cells. Both APF and NaF gels significantly induced apoptosis in L929 cells, with no notable apoptotic effects observed in HGF cells treated with these agents. Conversely, TiF₄ solution and NaF varnish consistently induced apoptosis across both cell lines, whereas SDF solution did not elicit significant apoptotic activity. In terms of genotoxicity, TiF₄ solution showed significant genotoxic effects, while SDF solution demonstrated the lowest genotoxic potential. The Bax/Bcl-2 ratios for all fluoride agents tested in the present study were found to be greater than 1, indicating that these agents induce apoptosis through the mitochondrial pathway, with a predominance of pro-apoptotic signals.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Silver Diamine Fluoride, which gained substantial attention especially during the COVID-19 pandemic, has emerged as a highly effective and minimally invasive option for arresting caries and preventing early enamel lesions. With its rapid action and favorable safety profile, SDF solution is increasingly recognized as a superior alternative to commonly used topical fluoride agents, particularly in clinical settings where traditional dental procedures may carry heightened risks or present logistical challenges.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical relevance: &lt;/strong&gt;This study provides critical insights into the biocompatibility profiles of commonly used fluoride agents, offerin","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1009"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of preprocedural mouth rinses (Chlorhexidine, essential oil, and hydrogen peroxide) in reducing bacterial aerosols during dental scaling.","authors":"Soma Hoseyni, Masoumeh Rostamzadeh, Himen Salimizand, Arian Azadnia, Farshad Rahimi, Shabnam Khalifehzadeh","doi":"10.1186/s12903-025-06308-4","DOIUrl":"https://doi.org/10.1186/s12903-025-06308-4","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to compare the efficacy of mouth rinsing with chlorhexidine, essential oil, and hydrogen peroxide mouthwashes in reducing bacterial infection in aerosols produced during dental scaling.</p><p><strong>Materials and methods: </strong>Eighty subjects were randomly assigned to four groups. Ten minutes before treatment, participants rinsed for 1 min with 10 mL of either chlorhexidine, essential oil, hydrogen peroxide, or water. Blood agar plates were used to collect aerosols during the scaling procedure, with plates placed at the patient's chest, dentist's chest, and assistant's chest. Plates were exposed for 30 min during and after treatment, incubated at 37 °C for 48 h, and the total number of colony-forming units (CFUs) was counted and analyzed using SPSS-24 software.</p><p><strong>Results: </strong>The mean age of participants was 35.01 years, with 57.5% female and 42.5% male. A statistically significant difference was observed in the number of bacterial colonies on the patient's chest plates (882.56 CFUs), dentist's chest (99.84 CFUs), and assistant's chest (48.49 CFUs) (p value < 0.001). Chlorhexidine mouthwash significantly reduced bacterial growth compared to the other groups.</p><p><strong>Conclusion: </strong>Rinsing with chlorhexidine mouthwash before dental treatment effectively reduces bacterial contamination in aerosols, thereby lowering the risk of infection for dental personnel and patients.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1004"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of periodontal disease in head and neck cancer patients after radiation therapy: a cross-sectional study.","authors":"Asmaa Abou-Bakr, Enji Ahmed, Hany William, Fatma E A Hassanein","doi":"10.1186/s12903-025-06391-7","DOIUrl":"https://doi.org/10.1186/s12903-025-06391-7","url":null,"abstract":"<p><strong>Background: </strong>Patients with head and neck cancer (HNC) receiving radiation therapy (RT) have complications affecting both general and dental health. While RT is effective against HNC, it negatively impacts oral tissues, including changes in periodontal attachment. This study aimed to evaluate the frequency of periodontal disease among HNC patients after RT in a sample of the Egyptian population, as well as to assess the associated risk factors.</p><p><strong>Materials and methods: </strong>A prospective cross-sectional study was conducted on 189 HNC patients attending a radiation center in Cairo, Egypt. Eligible patients underwent a full periodontal examination including plaque index (PI), bleeding on probing (BOP), clinical attachment level (CAL), and probing pocket depth (PPD). Subsequently, Clinical Oral Dryness Score (CODS), salivary flow rate and body mass index (BMI) were assessed to examine associations with periodontal health.</p><p><strong>Results: </strong>Periodontal disease was diagnosed in 183 (96.8%) HNC patients. Among them, 174 (95.08%) cases were diagnosed as periodontitis and 9 (4.9%) as gingivitis. The distribution of periodontitis different stages was as follows: Stage I was found in 21 (12.07%) cases, Stage II in 30 (17.24%), Stage III in 55 (31.61%), and Stage IV in 68 (39.08%). The correlation between the number of RT fractions and periodontal disease severity was not statistically significant (p = 0.837). However, there was a strong negative correlation between periodontitis stage and both body mass index (BMI) and salivary flow rate. In contrast, strong positive correlations were observed between periodontitis severity and RT dose, plaque percentage, and Clinical Oral Dryness Score (CODS).</p><p><strong>Conclusions: </strong>The frequency of periodontitis in the studied sample of HNC patients post RT was 95.08%, reflecting a notably high burden. The most prevalent periodontitis stage was the severe form (Stage IV). Higher periodontitis severity was found to be positively associated with RT dose, plaque percentage, and CODS, suggesting factors to plan future investigation on preventive care in HNC patients. While causality cannot be inferred due to the study design, these findings could be useful in developing more effective clinical management strategies in future research.</p><p><strong>Trial registration: </strong>The study was retrospectively registered on 29/10/2024 at ClinicalTrials.gov (NCT06667362).</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1008"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin resistance as a mediator between obesity and periodontitis risk.","authors":"Shuai Jiang, Chen Liang, Jing Jing, Mengmeng Wang, Hao Sun, Bingli Zuo","doi":"10.1186/s12903-025-06362-y","DOIUrl":"https://doi.org/10.1186/s12903-025-06362-y","url":null,"abstract":"<p><strong>Background: </strong>Obesity is a well-established risk factor for periodontitis, a chronic inflammatory disease with systemic implications. While diabetes has been proposed as a potential mediator in this relationship, its clinical heterogeneity limits its utility in causal modeling. Insulin resistance, quantified by the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), offers a more mechanistically grounded alternative.</p><p><strong>Objectives: </strong>This study aimed to investigate the associations between obesity, insulin resistance, and periodontitis, with a specific focus on the mediating role of HOMA-IR.</p><p><strong>Methods: </strong>Data from the National Health and Nutrition Examination Survey (NHANES, 2009-2012) including 8,473 participants were analyzed. Obesity was assessed using body mass index (BMI) and waist circumference (WC), and insulin resistance was measured using HOMA-IR. Periodontitis was evaluated using clinical attachment loss and probing depth. Multivariable logistic regression, restricted cubic splines, and mediation analyses were conducted.</p><p><strong>Results: </strong>Both BMI and WC were significantly associated with an increased risk of periodontitis (P < 0.05). HOMA-IR was positively associated with periodontitis risk (P < 0.01). Mediation analysis revealed that HOMA-IR mediated 63.44% of the association between BMI and periodontitis and 36.77% of that between WC and periodontitis. Nonlinear analyses showed no significant nonlinear trends.</p><p><strong>Conclusions: </strong>Insulin resistance, as reflected by HOMA-IR, plays a significant mediating role in the relationship between obesity and periodontitis. These findings underscore the importance of early metabolic regulation in mitigating obesity-related periodontal risk and provide mechanistic insight into the interplay between systemic and oral health.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1015"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related prevalence and correlation of dental and periodontal lesions in second molars adjacent to mesioangular and horizontally impacted mandibular third molars: a CBCT study.","authors":"Yudong Liu, Yang Zhou, Jianfeng He, Zhibin Wei, Yongqi Li, Libin Zhou","doi":"10.1186/s12903-025-06404-5","DOIUrl":"https://doi.org/10.1186/s12903-025-06404-5","url":null,"abstract":"<p><strong>Background: </strong>The management of asymptomatic impacted mandibular third molars (MTMs) remains controversial, particularly due to variations in impaction types and their associated risks. Mesioangular and horizontal impactions are common, yet their effects on adjacent mandibular second molars (MSMs) have not been thoroughly investigated. Clarifying the prevalence and severity of related pathologies and their correlation with age is crucial for clinical decision-making. This study aims to provide epidemiological evidence to support the management of mesioangular and horizontal MTMs.</p><p><strong>Methods: </strong>This study was a retrospective and cross-sectional observational study. CBCT data of 875 pairs of mesioangular and horizontal impacted MTMs and their adjacent MSMs in 643 patients were collected and evaluated by two observers. Prevalence of caries, external root resorption (ERR) and bone loss (BL) of MSMs, percentages of the severity of lesions and their correlations with patient age were calculated. The chi-square test was used to analyze the difference between each impaction group. Spearman rank correlation analysis was applied to analysis the correlations.</p><p><strong>Results: </strong>In all MSMs, the overall prevalence of caries, ERR and BL of MSMs were 20.91%, 15.09%, 27.66% respectively. The overall prevalence of caries, ERR, and BL of MSMs were 27.80%, 14.41% and 35.08% in mesioangular impact group and 6.67%, 16.49% and 12.28% in horizontal impact group. A significant positive correlation was observed between age and the prevalence of caries and BL in the mesioangular impaction group (p < 0.001), whereas age was positively correlated with the prevalence of ERR in the horizontal impaction group (p < 0.001).The severity of caries, BL and ERR were positively correlated with patient age in mesioangular impact group (p < 0.01). The severity of caries and BL were positively correlated with patient age in horizontal impact group (p < 0.05).</p><p><strong>Conclusions: </strong>Mesioangular impacted MTMs are more likely to cause caries and BL in adjacent teeth compared to horizontal impacted MTMs, whereas horizontal impacted MTMs tend to result in more severe ERR. Age plays a significant role in the occurrence and development of these diseases.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"1042"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral microbiome diversity and composition before and after chemotherapy treatment in pediatric oncology patients.","authors":"Egle Immonen, Lauri Paulamäki, Hannaleena Piippo, Atte Nikkilä, Liisa Aine, Timo Peltomäki, Olli Lohi, Mataleena Parikka","doi":"10.1186/s12903-025-06405-4","DOIUrl":"https://doi.org/10.1186/s12903-025-06405-4","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the impact of anticancer treatment on the oral microbiome in pediatric patients and its association with oral mucositis (OM).</p><p><strong>Materials and methods: </strong>A double-blind, randomized trial involving 34 pediatric cancer patients (ages 2-17.99) with solid or hematological malignancies. Mucosal swab samples were collected before and after chemotherapy. Patients underwent two 7-day rinse cycles-one with Caphosol and one with saline-in a randomized order. Bacterial DNA from 110 mucosal swabs was analyzed using 16S rRNA sequencing.</p><p><strong>Results: </strong>Chemotherapy altered bacterial composition. No life-threatening OM cases (WHO grade 4) were observed, but mild to severe OM (grades 1-3) occurred in three patients. In patients without oral lesions, Bergeyella genus was more abundant prior to treatment while Alloprevotella was more abundant in the post-treatment samples, compared to patients with lesions. OM was linked to distinct microbiome profiles, including Stenotrophomonas, Leptotrichia sp., Serratia sp.,Capnocytophaga sputigena, Sphingomonas sp., Parapusillimonas sp., Staphylococcus sp., and Turicibacter genera. Additionally, Burkholderia-Caballeronia-Paraburkholderia (p = 0.013) were more prevalent in the Caphosol group compared to the saline group.</p><p><strong>Conclusions: </strong>These findings indicate that chemotherapy-induced microbiome shifts associate with OM risk, highlighting the potential for microbial markers to predict high-risk patients and support protective strategies.</p><p><strong>Trial registration: </strong>The trial titled \"Supersaturated Calcium Phosphate Oral Rinse (Caphosol®) for the Prevention of Oral Mucositis in Children Undergoing Chemotherapeutic Treatments\" was registered on ClinicalTrials.gov (ID NCT02807337), with the first submission date 2016-06-07.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"981"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}