BMC Oral Health最新文献

{"title":"Comparative in vitro study on wear resistance and colour stability of 3D-printed, milled, and conventional PMMA denture teeth.","authors":"Yasmine Mahmoud Mohamed Elsharkawy, Hebatallah Tarek Mohamed, Tarek Mohamed Al Sayed El Saeedi, Amany Mostafa Saad Farahat","doi":"10.1186/s12903-025-05983-7","DOIUrl":"https://doi.org/10.1186/s12903-025-05983-7","url":null,"abstract":"<p><strong>Background: </strong>Digital dentures are a promising alternative to the conventional fabrication technique. However, their mechanical and optical properties require further evaluation, so this study aims to compare the wear resistance and colour stability of milled and 3D-printed polymethyl methacrylate denture teeth to conventional teeth. This is essential as too much wear can cause a loss of the vertical dimension of occlusion (VDO), which can compromise the chewing efficiency, esthetics, and even cause the dentures to break.</p><p><strong>Methods: </strong>Mandibular first molars denture teeth were manufactured using three different techniques, which were chosen to be assessed for wear resistance and colour stability. In the first group, conventionally prefabricated mandibular first molars were used; in the second group, the molars were milled from PMMA blocks; in the third group, the molars were fabricated from 3D printing resin (n = 7). The teeth were loaded on the chewing simulator to simulate the intraoral conditions, and then the volumetric changes were evaluated using surface matching software. Teeth were subjected to aging using the thermocycler, and colour stability was evaluated using a spectrophotometer.</p><p><strong>Results: </strong>The null hypothesis was rejected, indicating significant differences between the groups. For wear resistance, the highest mean wear (RMS) value was reported in the conventional group, 1.806 ± 0.085, followed by the printed group, 0.021 ± 0.006, and then the milled group, 0.019 ± 0.005. For colour stability, the highest mean value of colour change (Delta E) was reported in the printed group 2.996 ± 0.445, followed by the conventional group 2.725 ± 0.234, and then the milled group 0.539 ± 0.118.</p><p><strong>Conclusion: </strong>Milled PMMA generally demonstrates better wear resistance and colour stability compared to 3D-printed and conventionally processed PMMA. 3D-printed PMMA exhibits comparable wear resistance to milled PMMA. 3D-printed PMMA demonstrated comparable colour stability to conventional resin.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"656"},"PeriodicalIF":2.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety in periodontally healthy, stage III/IV periodontitis with and without smoking: a cross-sectional study.","authors":"Abhay P Kolte, Rajashri A Kolte, Amruta S Verma, Vrushali N Lathiya, Saquib A Shahab","doi":"10.1186/s12903-025-05996-2","DOIUrl":"https://doi.org/10.1186/s12903-025-05996-2","url":null,"abstract":"<p><strong>Background: </strong>Psychological stress and smoking have been known as pertinent risk factors associated with various inflammatory diseases like periodontal disease. So, the aim of this study was to evaluate and correlate anxiety in Periodontally healthy, Stage III/IV Periodontitis patients with and without smoking.</p><p><strong>Methods: </strong>120 participants included in the study were divided equally into four groups of healthy non-smokers (Group I), healthy smokers (Group II), non-smokers with untreated Stage III or IV periodontitis (Group III) and smokers with untreated Stage III or IV periodontitis (Group IV). The anxiety levels of the patients were assessed using the Zung's self-rating anxiety scale. Socioeconomic status, smoking exposure through a questionnaire and the clinical parameters Probing pocket depth (PPD), Clinical attachment levels (CAL), Gingival index (GI) and Plaque index (PI) were recorded.</p><p><strong>Results: </strong>The clinical periodontal parameters were compared within and across the groups at the four different anxiety levels and depicted a significant increase with the increase in the anxiety levels of the patients. The correlation of CAL with the anxiety score in Group III and Group IV was high positive (r = 0.926 and 0.823) and highly significant. (p-value < 0.0001 respectively). Also, a strong positive association was seen between duration, frequency of smoking and anxiety scores. (r = 0.824 and 0.853 respectively).</p><p><strong>Conclusion: </strong>The anxiety scores showed a positive correlation with PPD and CAL in Group III and IV and it was high positive in smokers.</p><p><strong>Clinical trial registry of india registration number: </strong>CTRI/2023/06/053408.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"654"},"PeriodicalIF":2.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary EGF: EGFR ratio as potential early diagnostic biomarker for oral cancer detection in tobacco chewers: a preliminary cross-sectional study.","authors":"Ruchika Kaul-Ghanekar, Ravi S Kharat, Prerna Raina, Amol Chaudhary, Shraddha Walekar-Ghaisas","doi":"10.1186/s12903-025-05982-8","DOIUrl":"https://doi.org/10.1186/s12903-025-05982-8","url":null,"abstract":"<p><strong>Background: </strong>Tobacco chewing and smoking are major risk factors for oral cancer, with Oral Squamous Cell Carcinoma (OSCC), comprising approximately 90% of cases, especially in South-Central Asia. This study examines the early diagnostic value of salivary Epidermal Growth Factor (EGF) and Epidermal Growth Factor Receptor (EGFR) for OSCC in long-term chewers of tobacco.</p><p><strong>Methods: </strong>This study assessed salivary EGF and EGFR concentrations by Enzyme-Linked Immunosorbent Assay (ELISA), in three groups: Healthy Controls (HC, n = 41), Tobacco Chewers with a 10-years history of tobacco use (TC, n = 41), and newly diagnosed OSCC patients (with tobacco chewing history of more than 10 years) with no prior history of neoplasms or anticancer treatment (OSCC, n = 19). All participants were over the age of 35.</p><p><strong>Results: </strong>Salivary EGF levels were significantly reduced, while EGFR levels were elevated in tobacco chewers (TC) and newly diagnosed OSCC patients compared to healthy controls (HC), with no significant difference observed between TC and OSCC groups. Notably, the EGF: EGFR ratio demonstrated better diagnostic performance for OSCC in TC compared to EGF or EGFR alone. ROC analysis highlighted the potential of these biomarkers as diagnostic tools for OSCC in TC.</p><p><strong>Conclusion: </strong>Salivary EGF: EGFR ratio may serve as an early diagnostic biomarker for OSCC in TC. Reduced EGF and elevated EGFR levels suggest their role in disease progression, warranting further large-scale studies for clinical validation.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"663"},"PeriodicalIF":2.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of survival rate in patients with tongue squamous cell carcinoma: a retrospective single-center study.","authors":"Narges Ghazi, Nasrollah Saghravanian, Kazem Anvari, Shadi Saghafi Khadem, Melika Hoseinzadeh, Reza Barzanouni","doi":"10.1186/s12903-025-05850-5","DOIUrl":"https://doi.org/10.1186/s12903-025-05850-5","url":null,"abstract":"<p><strong>Background: </strong>The tongue squamous cell carcinoma (TSCC) is a highly prevalent form of oral squamous cell carcinoma with poor prognosis and aggressive behavior. The present study aimed to evaluate the association between tumor grade, clinical stage, and survival outcomes in patients with TSCC..</p><p><strong>Methodology: </strong>Patients with a history of having TSCC, complete clinical and demographic data (age and gender), and a through clinical and histopathological follow-up period of six months were included. The overall survival (OS) and disease-free survival (DFS) of the participants were determined.Histopathological grade was assessed as a secondary objective. Kaplan-Meier survival analysis was performed, and data analysis was conducted using the Kaplan-Meier method, log-rank test and a multivariable Cox regression model.</p><p><strong>Results: </strong>A total number of 162 patients were included with the mean age of 59.6 ± 15.7 years. The majority of the patients (53.1%) were women. Most patients were classified as Grade I (37.7%) and Stage I (46.3%). The local recurrence and metastasis rates were 12.3% and 4.3%, respectively. The median OS and DFS of the patients included 46 ± 7.8 months and 36 ± 5.7 months, respectively. Five-year OS and DFS rates of 41.5% and 36%. No significant correlation was found between OS and DFS with patients' gender or histological grade. However, OS and DFS were inversely related to the clinical stage and age, showing statistical significance (P < 0.05). Additionally, OS was significantly influenced by tumor size, lymph node involvement, and metastasis (P < 0.05). Factors such as tumor size, lymph node involvement, clinical stage, and patient age significantly impacted OS (P < 0.05). In contrast, lymph node involvement, clinical stage, and patient age were significantly associated with DFS (P < 0.05).</p><p><strong>Conclusion: </strong>Clinical factors including tumor size, lymph node involvement, clinical stage, and patient age were associated with OS. All these variables were also associated with DFS, except for tumor size. The histopathological grade was not influential on OS or DFS.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"658"},"PeriodicalIF":2.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xerostomia and associated factors among adults with HIV on HAART attending voluntary counseling and testing (VCT) clinics in Dar Es Salaam.","authors":"Lilian Ephrem Mkonyi, Luciana Albert Mmary","doi":"10.1186/s12903-025-05993-5","DOIUrl":"https://doi.org/10.1186/s12903-025-05993-5","url":null,"abstract":"<p><strong>Background: </strong>Adequate saliva quantity and quality are necessary for proper oral function and protection. Xerostomia, or dry mouth, is a common complaint among people living with HIV (PLHIV) which increases their risk of acquiring oral diseases. This study aimed to assess the magnitude of xerostomia and the associated factors in this group of patients.</p><p><strong>Methods: </strong>A descriptive cross-sectional hospital-based study was conducted among 420 PLHIV on highly active antiretroviral therapy (HAART) aged 18 years and above. Informed consent was obtained from the participants during data collection. The xerostomia was assessed using a questionnaire. Pearson's χ² test was used to correlate independent (sociodemographic factors, oral health-related, and HIV-related factors) and dependent variables (xerostomia). Univariate and adjusted multinomial logistic regression were used to determine the odds ratio (OR) of xerostomia.</p><p><strong>Results: </strong>Xerostomia was observed in 36.3% of the respondents. The chi-square test showed a significantly higher proportion of xerostomia among the unemployed (p = 0.014), those who were HIV diagnosed up to five years (p = 0.014), and those having CD4⁺ counts ≥ 500 cells/ mm³ (p = 0.03). In multivariate analysis, higher odds of having xerostomia were found among participants with higher viral load (OR = 2.6; CI = 1.07-6.3), whereas lower odds were found among self-employed participants (OR = 0.48; CI = 0.28-0.82) and employed participants (OR = 0.52; CI = 0.27-0.98).</p><p><strong>Conclusion: </strong>The prevalence of xerostomia is moderately high among PLHIV. Higher viral load and unemployment were the associated factors with xerostomia. Low CD4⁺ counts, duration of HAART use, and HAART regime were not associated with xerostomia.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"655"},"PeriodicalIF":2.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The intersection of cannabis use and oral health among 2SLGBTQI+ youth: a qualitative study protocol.","authors":"Abbas Jessani, Fabio Arriola-Pacheco, Alexia Athanasakos, Karla Kenny, Mario Brondani, Herenia P Lawrence","doi":"10.1186/s12903-025-05906-6","DOIUrl":"https://doi.org/10.1186/s12903-025-05906-6","url":null,"abstract":"<p><strong>Background: </strong>Two-Spirit, lesbian, gay, bisexual, transgender, queer or questioning, intersex, or other sexual orientations and gender identities (2SLGBTQI+) youth face multiple social and structural disparities and barriers that contribute to a sense of mistrust in the provision of healthcare services, including oral health. Cannabis use is also high among 2SLGBTQI+ individuals; however, unknowns exist regarding recreational use and its impact on oral health. Our research aims to explore the intersectionality of 2SLGBTQI+ youth, oral health, and cannabis consumption.</p><p><strong>Methods: </strong>This qualitative study, guided by community-based participatory research and interpretative phenomenological approaches, will recruit consenting 2SLGBTQI+ youth, aged 19 and older, accessing services at Youth Opportunities Unlimited in London, Canada. Approximately 25 to 30 participants will be recruited to complete a one-on-one in-depth interview or focus group to collect information on their perception about the relationships between cannabis use and oral health.</p><p><strong>Discussion: </strong>Recognizing the self-perceived pathways through which cannabis impacts oral health will prompt the development of theories, raise awareness, and support advocacy efforts for and by 2SLGBTQI+ youth, while also providing valuable insights for the community and healthcare providers at large.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"653"},"PeriodicalIF":2.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing PMMA properties: a comprehensive study of nanographene oxide and Boron nitride impact through In-Vitro analysis.","authors":"Hessah Alahmad, Reem Alamir, Mohammad Asadzadeh, Umer Daood, Syed Saad Bin Qasim","doi":"10.1186/s12903-025-05994-4","DOIUrl":"https://doi.org/10.1186/s12903-025-05994-4","url":null,"abstract":"<p><strong>Background: </strong>Polymethylmethacrylate is a commonly used biomaterial in dentistry. Although the material have been used for several years it has some limitations with respect to physical and mechanical properties. Researchers are exploring the potential of novel nanomaterials like nanographene oxide (nGO) and hexagonal boron nitride (hBN) to be used as a reinforcing agent. Therefore, the current investigation sought to evaluated physical, chemical, mechanical and antimicrobial potential of PMMA reinforced with nGO and hBN alone and synergistically as well.</p><p><strong>Methods: </strong>Four different groups were prepared including the control group (G1)0.2.5 wt% nGO was added to the liquid component (G2), 1 wt% hBN was added to the powder component (G3) and 2.5 wt % nGO with 1 wt % hBN combined (G4.) The resulting nanocomposite were characterized using microhardness, flexural and compressive strength analysis, contact angle analysis and degree of conversion was also calculated using Fourier Transform Infrared spectroscopy. The antimicrobial efficacy was assessed against Candida albicans. Statistical analysis was performed to determine the difference between the groups. One-way ANOVA was performed followed by Tukey's post hoc test for multiple comparisons between the groups.</p><p><strong>Results: </strong>The addition of nGO (17.67 ± 2.41 HV) ( p > 0.001) significantly increased the microhardness compared to the unmodified PMMA (15.91 ± 1.57 HV) (p > 0.001).The addition of both, nGO and hBN enhanced hydrophilicity (61.4° ± 2.36) and the surface roughness. Degree of conversion was found to be less than the control specimens for all experimental groups. G2 showed significantly less Candida albicans attachment compared to G1 (p < 0.05).</p><p><strong>Conclusion: </strong>The synergistic effect of nGO and hBN on PMMA shows promise for enhancing wettability and antimicrobial properties. However, the trade-off with lower polymerization conversion and increased roughness needs to be addressed. Future work could focus on optimizing the composition and processing conditions to maximize beneficial properties while minimizing negative impacts on physiochemical, mechanical performance and microbial adhesion.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"659"},"PeriodicalIF":2.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparisons of facial soft tissue characteristics in adult patients with various mandibular divergence patterns.","authors":"Anthony T Macari, Antoine E Hanna, Michelle El Chekie","doi":"10.1186/s12903-025-06054-7","DOIUrl":"https://doi.org/10.1186/s12903-025-06054-7","url":null,"abstract":"<p><strong>Background: </strong>The alignment of craniofacial structures in three dimensions-transverse, vertical, and sagittal-determines facial esthetics. While skeletal and dental factors influence these outcomes, soft tissue characteristics, especially facial soft tissue (FST) thickness, are increasingly recognized as important. However, few studies have examined the impact of vertical facial divergence on soft tissue variation, particularly in the middle and lower thirds of the face.</p><p><strong>Objective: </strong>This study aimed to evaluate the association between vertical facial divergence and facial soft tissue characteristics of lower and upper thirds in adult patients.</p><p><strong>Methods: </strong>A total of 120 non-growing individuals (60 men, 60 women) with an average age of 27.87 years (range: 18-56) seeking orthodontic treatment were included. Participants were stratified into four groups based on mandibular plane inclination to anterior cranial base (MP/SN): Group 1: MP-SN ≤ 27°, group 2: 27°< MP-SN ≤ 32º, group 3: 32°< MP-SN < 37°, and group 4: MP-SN ≥ 37°. Lateral cephalometric radiographs were used to measure FST thickness in the horizontal plane at specific anatomical landmarks, including the base of the forehead, nose, lips, and chin. Additionally, lip length, chin projection, and angular inclinations were assessed. Group comparisons were performed using one-way ANOVA followed by the post-hoc Benferroni test. The strength of the linear relationship between variables was investigated using the Pearson correlation test. Statistical significance was set at p = 0.05.</p><p><strong>Results: </strong>Significant differences in facial soft tissue characteristics were observed across groups. Hyperdivergent individuals (Group 4) exhibited significantly (p < 0.001) increased total facial height (TFH), lower facial height (LFH), and longer upper and lower lips compared to hypodivergent individuals (Group 1). Group 4 also had thinner soft tissue (p < 0.001) at the chin (Gn-Gn' and Me-Me'). Shallower mental sulcus and more obtuse chin angle existed in Group 4. Gender differences were noted in chin extension and throat angle. Positive correlations were found between MP/SN and various soft tissue measurements, including lip length and chin projection. No statistically significant differences were observed among the four groups in the upper face neither in linear nor in angular measurements.</p><p><strong>Conclusions: </strong>Vertical facial divergence significantly influences soft tissue characteristics, particularly in the lower third of the face. Hyperdivergent individuals exhibit increased lip length and reduced chin thickness. Nose length and projection did not differ between the different divergent groups. These findings have clinical implications for orthodontic treatment planning, highlighting the need for individualized approaches based on vertical facial patterns.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"660"},"PeriodicalIF":2.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there a relationship between periodontal conditions and asprosin levels in gingival crevicular fluid, saliva and serum?","authors":"Sedat Tutuş, Abdulsamet Tanık, Osman Fatih Arpağ, Muhittin Önderci","doi":"10.1186/s12903-025-06014-1","DOIUrl":"https://doi.org/10.1186/s12903-025-06014-1","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate the presence of asprosin hormone in the biological fluids of patients with periodontal inflammation and compare it to those with periodontal healthy.</p><p><strong>Materials and methods: </strong>Seventy-five individuals between the ages of 18 to 45, 25 periodontal healthy, 25 with gingivitis, and 25 with periodontitis, were included in the study. Gingival crevicular fluid (GCF), blood serum and saliva were obtained from individuals in each group. Tumour necrosis factor-alpha (TNF-α) and asprosin levels in these fluids were determined using the ELISA. Clinical periodontal measurements were recorded and body mass index was calculated. One-way ANOVA and Bonferroni tests were performed for statistical analysis. Spearman test was used to evaluate correlations. The significance level was determined as p < 0.05.</p><p><strong>Results: </strong>Body mass index values were not different between the groups (p = 0.446). Clinical periodontal measurements were significantly higher in the periodontitis group. Concentrations of TNF-α in GCF, serum and saliva increased significantly in patients with gingivitis and periodontitis (p < 0.001). The higher TNF-α levels were obtained in patients with periodontitis than in individuals with gingivitis (p = 0.001). While asprosin levels were found to be significantly higher in patients with gingivitis and periodontitis (p < 0.001), no significant difference was observed between both groups (p > 0.05). GCF-asprosin levels were positively correlated with the concentrations in serum and saliva in all individuals included in the study (p < 0.05).</p><p><strong>Conclusion: </strong>The periodontal inflammation caused an increase in asprosin hormone in gingival crevicular fluid independently of the type of periodontal disease.</p><p><strong>Trial registration: </strong>This study is registered with number of \"NCT06627972\" in ClinicalTrials.gov website from the date of October 3, 2024.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"651"},"PeriodicalIF":2.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of trabecular bone microstructure and cortical morphology using cone-beam and micro-CT images: impact of tube voltage setting.","authors":"Oğuzhan Baydar, Erinc Onem, Ali Mert, B Guniz Baksi","doi":"10.1186/s12903-025-05855-0","DOIUrl":"https://doi.org/10.1186/s12903-025-05855-0","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of various tube voltage (kV) settings on the accuracy of cone-beam computed tomography (CBCT) images in measuring trabecular microstructure and cortical morphology, using micro-CT (μCT) as the reference.</p><p><strong>Methods: </strong>Ten bone samples of sheep mandibles were scanned using both μCT and CBCT at three different tube voltage settings (80, 85, and 90 kV). Identical regions of interest (ROIs) on trabecular and cortical bones were analyzed in all images. Measurements of trabecular microstructure included bone volume fraction (BV/TV), trabecular thickness (Tb.Th) and space (Tb.Sp), while thickness (Ct.Th) and area (Ct.Ar) of cortical bone were measured to determine cortical morphology. Measurements were compared using paired t-test, while agreement between measurements of two modalities was assessed using Bland-Altman analysis. One-way ANOVA was used to determine differences in measurements of CBCT images at different kVs (p < 0.01).</p><p><strong>Results: </strong>Compared to μCT, CBCT overestimated trabecular parameters and Ct.Th but underestimated Ct.Ar, with high agreement observed between the methods. Significant differences were found for all measurements except BV/TV and Ct.Ar at all kVs. No differences were observed between CBCT measurements at different tube potentials.</p><p><strong>Conclusion: </strong>The tube voltage of CBCT has minimal impact on the measurement accuracy of most microstructural parameters. BV/TV and Ct.Ar measurements may be particularly preferred for bone evaluations using CBCT images.</p>","PeriodicalId":9072,"journal":{"name":"BMC Oral Health","volume":"25 1","pages":"664"},"PeriodicalIF":2.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}