BMC Pregnancy and Childbirth最新文献

{"title":"The effect of virtual reality (VR) glasses and therapeutic touch (TT) on pain, anxiety, and patient satisfaction during intrauterine insemination (IUI) compared to standard care: a single-blind, randomized controlled trial.","authors":"Sümeyye Bal, Neşe Karakaya, Emine Koç, Davut Güven","doi":"10.1186/s12884-025-07435-0","DOIUrl":"10.1186/s12884-025-07435-0","url":null,"abstract":"<p><strong>Background: </strong>Intrauterine insemination (IUI) also found that this experience was associated with anxiety. Therefore, measures must be taken to reduce or eliminate the pain and anxiety associated with it.</p><p><strong>Objectives: </strong>This study investigated the effect of virtual reality glasses (VRG) and therapeutic touch (TT) on pain, anxiety and satisfaction during intrauterine insemination.</p><p><strong>Methods: </strong>A single blind randomized controlled trial design was used. Patients were randomized into three groups: the virtual reality group (VRG, n = 32), the therapeutic touch group (TT, n = 32), and the control group (CG, n = 32). The study was conducted between January and June 2022 in the obstetric outpatient clinics of a public hospital in northern Türkiye. Anxiety was evaluated using the State Anxiety Inventory. Pain, and satisfaction were evaluated using the Visual Analogue Scale [VAS]. \"The study used non-parametric tests for its statistics.\"</p><p><strong>Results: </strong>There was a significant difference in the pain level of the VRG group during IUI was lower than those of CG 3.7 ± 2.7 and TT 3.6 ± 2.9 (p = 0.01). Women were most satisfied with the TT application 9.2 ± 1.1 in the IUI procedure (p = 0.000). Anxiety levels after IUI were lower in the TT 43.0 ± 4.2 and VRG 43.9 ± 4.4 than in CG 49.9 ± 4.0 (p = 0.000).</p><p><strong>Conclusion: </strong>VRG application was effective in reducing pain associated with IUI procedure in women. Although the use of VRG with music reduced the pain associated with IUI more than the TT application, the women left the TT application satisfied.</p><p><strong>Trial registration: </strong>The study was registered at the Clinical Trials.gov website under the code NCT05192330. The first trial registration date was (12/01/2022).</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"361"},"PeriodicalIF":2.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal alcohol consumption during pregnancy and associated factors among pregnant women in Tanzania: evidence from the 2022 Tanzania Demographic and Health Survey.","authors":"Victoria Godfrey, Elihuruma Eliufoo, Immaculata P Kessy, Mussa Bago, Mtoro J Mtoro, Azan Nyundo","doi":"10.1186/s12884-025-07149-3","DOIUrl":"10.1186/s12884-025-07149-3","url":null,"abstract":"<p><strong>Background: </strong>Maternal alcohol consumption remains a significant public health concern. The consumption is associated with an increased risk of miscarriage, stillbirth, and Fetal Alcohol Spectrum Disorders, which can impair fetal growth and lead to low birth weight. This study aims to investigate the prevalence of alcohol use among pregnant women and identify associated factors utilising data from the 2022 Tanzania Demographic and Health Survey and Malaria Indicator Survey (TDHS-MIS).</p><p><strong>Methods: </strong>This analytical cross-sectional survey design utilised secondary data from the 2022 TDHS-MIS. The survey employed a multistage cluster sampling method to generate representative national and sub-national health and health-related indicators between February and July 2022. A total of 1,182 pregnant women were included in the analysis. Data analysis involved descriptive statistics and binary logistic regression using STATA version 18.5 to assess factors associated with maternal alcohol consumption. Adjusted odds ratios (aOR) with 95% confidence intervals (CI) were computed to estimate the strength of the association between independent variables and alcohol use.</p><p><strong>Results: </strong>The mean age of the participants was 27.3 years (standard deviation: 6.9). The overall prevalence of alcohol consumption during pregnancy among pregnant women in Tanzania was 3.9% (95% CI: 2.8-5.4). Factors associated with alcohol consumption were women aged 25-34 (aOR = 5.17, 95%CI: 1.62-16.51) and more than 35 years of age (aOR = 20.89, 95%CI: 6.55-66.62), women who were never married (aOR = 7.89, 95%CI: 2.20-28.25), On the other hand, women living in the western zone (aOR = 0.20, 95%CI: 0.04-0.88).</p><p><strong>Conclusion: </strong>The study reveals a notable prevalence of alcohol consumption during pregnancy in Tanzania. Key demographic factors influencing alcohol use include maternal age, marital status, and prominent regional disparities, notably lower rates in Zanzibar compared to the western zone. These findings highlight the necessity for targeted public health initiatives to educate pregnant women. This was a cross-sectional survey, which limited the causal relationship among the observed factors.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"359"},"PeriodicalIF":2.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of spontaneous abortion and lifestyle with diabetes mellitus in women: a cross-sectional study in UK Biobank.","authors":"Sanwei Liu, Yangping Chen, Aimu Zhang, Xinxiao Chen, Lei Yuan, Binbin Song","doi":"10.1186/s12884-025-07461-y","DOIUrl":"10.1186/s12884-025-07461-y","url":null,"abstract":"<p><strong>Background: </strong>Spontaneous abortion has been associated with higher risk of type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus (GDM), while the evidence remains equivocal. This study aimed to examine the association between spontaneous abortion and the risk of T2DM and GDM, and assesses whether lifestyle factors modified this association.</p><p><strong>Methods: </strong>This cross-sectional study used data from the UK Biobank, recruiting 170 599 ever-pregnant women from 22 assessment centers in England, Scotland, and Wales between 2006 and 2010. History of spontaneous abortion was self-reported and was confirmed by using medical records, categorized as none, 1, 2, or ≥3 spontaneous abortions. The primary outcomes, T2DM and GDM, were ascertained from medical records using ICD-10 codes. Multivariable logistic regression was performed to estimate the adjusted odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for sociodemographic and health factors (e.g., age, ethnicity, cancer, chronic hypertension), reproductive factors (e.g., use of oral contraceptives, use of hormone treatment, hypertensive disorders of pregnancy), and lifestyle score. The lifestyle score was constructed based on smoking status, alcohol intake, physical activity, television viewing time, sleep duration, and diet quality. Effect modification by lifestyle score was assessed using multiplicative interaction terms in the regression models.</p><p><strong>Results: </strong>Among 170 599 ever-pregnant women (mean [SD] age, 56.4 [8.0] years), a history of spontaneous abortion was associated with higher odds of T2DM (OR 1.17, 95% CI 1.10-1.24) and GDM (OR 1.38, 95% CI 1.20-1.60). The odds were higher for recurrent spontaneous abortions (for T2DM: ORs were 1.33 [95% CI 1.14-1.56] for three or more spontaneous abortions, 1.07 [95% CI 0.93-1.23] for two, and 1.09 [95% CI 1.01-1.17] for one compared with none; for GDM: the corresponding ORs were 2.01 [95% CI 1.48-2.71], 1.21 [95% CI 0.90-1.64], and 1.20 [95% CI 1.01-1.42], respectively). The odds of T2DM and GDM higher with less healthy lifestyle behaviors in both categories of spontaneous abortion, although no significant interactions between spontaneous abortion and lifestyle score were observed (P_-interaction>0.05).</p><p><strong>Conclusions: </strong>Spontaneous abortion was associated with higher odds of T2DM and GDM, with a stronger association observed in women who experienced recurrent spontaneous abortions. It is imperative to integrate reproductive history into routine diabetes risk assessment, particularly for women with a history of multiple spontaneous abortions.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"362"},"PeriodicalIF":2.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between prepregnancy BMI and gestational weight gain(GWG) with preeclampsia: a study based on restricted cubic spline.","authors":"Luhan Zhang, Juan Ding, Jiangli Liu, Jing Ma, Rui Shi, Tian Chen, Guifeng Ding","doi":"10.1186/s12884-025-07449-8","DOIUrl":"10.1186/s12884-025-07449-8","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the nonlinear associations between prepregnancy body mass index(BMI), gestational weight gain(GWG), and the risk of preeclampsia(PE) using maternal and infant cohort data, thereby providing a scientific foundation for preventive strategies.</p><p><strong>Methods: </strong>Pregnant women with regular obstetric checkups in Urumqi Youai Hospital were selected as study subjects from January 2020 to June 2024. They were divided into the PE group and the non-PE group. Baseline information and pregnancy outcomes were collected, and logistic regression analysis was employed to ascertain the impacts of diverse factors on the odds of developing PE; the restricted cubic spline was used to test the nonlinear relationship between prepregnancy BMI and GWG with PE.</p><p><strong>Results: </strong>13,294 pregnant women were included in the study, and 559 (4.20%) had PE.The prevalence of PE in underweight, normal-weight, overweight, and obese women was 1.72%, 2.85%, 6.60%, and 16.05%, respectively. However, after adjusting for confounders, only overweight and obesity were significantly associated with elevated PE odds. Logistic regression results showed that the OR was 1.68(95% CI:1.30-2.18) for the comparison between overweight and normal BMI groups, the OR was 3.16(95%CI:2.08-4.79) for the comparison between obesity and normal BMI groups. Restricted cubic spline showed that the association between prepregnancy BMI and the odds of PE showed an inverse L-shaped curve, with an inflection point of 21.5 kg/m²; the association between GWG and the odds of PE showed a J-shaped curve, with a GWG of 10.94-15.90 kg being at the lowest odds for the development of PE. For pregnant women with prepregnancy underweight, the odds of PE were significantly increased when their GWG exceeded 21.63 kg. Similarly, for those with prepregnancy normal weight, a significant elevation in the odds of PE was observed when their GWG surpassed 15.90 kg.</p><p><strong>Conclusion: </strong>There is a non-linear relationship between prepregnancy BMI, GWG, and PE, and prepregnancy weight management and gestational weight monitoring are important for the prevention of PE.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"360"},"PeriodicalIF":2.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning combined with infrared spectroscopy for detection of hypertension pregnancy: towards newborn and pregnant blood analysis.","authors":"Sara Maria Santos Dias da Silva, Marcelo Saito Nogueira, Jaqueline Maria Brandão Rizzato, Simone de Lima Silva, Sheila Cavalca Cortelli, Roger Borges, Herculano da Silva Martinho, Rodrigo Augusto Silva, Luis Felipe das Chagas E Silva de Carvalho","doi":"10.1186/s12884-024-06941-x","DOIUrl":"10.1186/s12884-024-06941-x","url":null,"abstract":"<p><p>Biochemical changes in the cervix during labor are not well understood. This gap in knowledge is significant, as understanding the precise biochemical processes can provide critical insights into the mechanisms of labor and potentially inform better clinical practices for monitoring and managing pregnancy and childbirth. Fourier-transform infrared (FT-IR) spectroscopy as a non-invasive optical technique, it has the potential sensibility to detect biochemical components. This technology operates by meansuring the vibrational energy of molecular composition and structural changes occurring in the tissue. A total of 30 pregnant participants undergoing either spontaneous or induced labor were recruited. We detected several biochemical changes during labor, including a significant decrease in FT-IR spectral features associated with collagen and other extracellular matrix (ECM) proteins, attributed to collagen dispersion. Specifically, the amide I and amide II bands, which are indicative of protein secondary structure, showed marked reductions. Our results have demonstrated that FT-IR spectroscopy is sensitive to multiple biochemical remodeling changes in the cervix during labor. Traditional methods have limitations, either due to their invasiveness or insufficient sensitivity to detect subtle biochemical alterations, therefore, FT-IR spectroscopy may be a valuable noninvasive tool for objective cervical assessment to potentially guide clinical labor management.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"358"},"PeriodicalIF":2.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health related quality of life and associated factors after cesarean delivery among postpartum mothers in Gondar, Ethiopia: a cross-sectional study.","authors":"Daniel Getaneh Damtie, Misganaw Mengie Workie, Mulualem Endeshaw Zeleke, Wubie Birlie Chekol","doi":"10.1186/s12884-025-07478-3","DOIUrl":"10.1186/s12884-025-07478-3","url":null,"abstract":"<p><strong>Background: </strong>Health-related quality of life following cesarean delivery can be compromised due to the physical, mental, and emotional impacts of surgery and anesthesia. Despite the critical nature of the postpartum period after cesarean delivery, it remains under-explored, with most studies focusing on vaginal deliveries and neglecting the unique challenges of cesarean recovery. Therefore, this study aimed to assess health related quality of life and associated factors after caesarean delivery among postpartum mothers in Gondar, Ethiopia.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in public health facilities of Gondar town using the Medical Outcomes Study Short Form-36. Data were collected from 424 postpartum women following cesarean delivery between April and June 2024 through face-to-face interviews, semi-structured questionnaires, and medical chart reviews. Simple random sampling was used, with participants proportionally allocated to each health facility. Data were entered into Epi-data version 4.6 and analyzed using SPSS version 25. Logistic regression models were applied to predict the health-related quality of life.</p><p><strong>Results: </strong>Among 418 post caesarean deliveries, 278 (66.5%) had lower level of health-related quality of life. The mean scores of physical component summary, mental component summary and overall health related quality of life were found 48.22 ± 5.63, 47.62 ± 6.02 and 47.92 ± 4.28 respectively. Factors associated with lower overall health related quality of life were postnatal care less than two (AOR = 2.58, 95% CI = 1.59-4.19), pregnancy complications [AOR 5.32, 95% CI (2.69-10.54)], general anesthesia (AOR = 2.36, 95% CI = 1.08-5.14), perceived pain after discharge (AOR = 2.64, 95% CI = 1.61-4.35) and postpartum depression (AOR = 2.41, 95% CI = 1.22-4.77).</p><p><strong>Conclusion: </strong>Two-thirds of postpartum mothers had low health related quality of life after cesarean delivery. Key factors included inadequate postnatal care, postpartum depression, anesthesia type, pregnancy complications, and perceived pain. We suggest that health care providers need to give particular attention to mothers during the perioperative period and increased postnatal care services to improve maternal well-being.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"355"},"PeriodicalIF":2.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the intolerance of uncertainty scale-12 in a sample of pregnant people.","authors":"Kayla Costello, C Alix Timko, Drew Anderson, Julia M Hormes","doi":"10.1186/s12884-025-07434-1","DOIUrl":"10.1186/s12884-025-07434-1","url":null,"abstract":"<p><strong>Background: </strong>Intolerance of uncertainty (IU) has been proposed as a transdiagnostic mechanism driving anxiety, depression, and eating disorder symptoms. Pregnancy is a time of significant uncertainty, yet few studies have examined the measurement of IU and its impacts on pregnant people. The current study aimed to examine the psychometric performance of two versions of the Intolerance of Uncertainty Scale (IUS-27 and IUS-12) and their associations with psychopathologies common in pregnancy.</p><p><strong>Methods: </strong>This study is a secondary analysis of participants (n = 254) recruited for a larger study of a single-session intervention targeting disordered eating in pregnancy. We examined fit of participant baseline data with IUS-27 and IUS-12 factor structures using confirmatory factor analyses. We also assessed associations between IU and emotion dysregulation and depression and eating disorder symptoms, controlling for age, parity, and perceived social status.</p><p><strong>Results: </strong>The IUS-12 provided superior fit to the data (CFI = 0.95; TLI = 0.93; RMSEA = 0.09) compared to the IUS-27. The IUS-12 was significantly (all p < 0.05) correlated with measures of emotion dysregulation (r = 0.67), depression (r = 0.58), and eating disorders (r = 0.37). Inhibitory IU rather than prospective IU was generally significantly associated with greater psychopathology (ß range = 0.46 - 3.51, p's < 0.01).</p><p><strong>Conclusions: </strong>Results from this study provide initial support for the IUS-12 as a valid measure of IU in pregnant people and suggest that IU is strongly associated with measures of depression, emotion dysregulation, and eating disorder behaviors in this population. Severe psychological distress in pregnancy has been linked to complications in gestation and delivery and overall poor birth outcomes. Clinicians and doctors should consider using the IUS-12 as a general measure of psychological distress among pregnant patients.</p><p><strong>Trial registration: </strong>The trial from which these data were drawn is registered at clinicaltrials.gov, NCT06129461 (registered on November 10, 2023).</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"363"},"PeriodicalIF":2.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomised feasibility tolerability study of aminophylline for the prevention of preterm labour.","authors":"Natasha Singh, Nishel Mohan Shah, Gavin Sooranna, Miriam Bourke, Angela Yulia, Cheryl Battersby, Rachel M Tribe, Mark R Johnson","doi":"10.1186/s12884-025-07488-1","DOIUrl":"10.1186/s12884-025-07488-1","url":null,"abstract":"<p><strong>Background: </strong>Progesterone is known to maintain uterine quiescence as pregnancy advances. Recently, its efficacy in preventing preterm birth has been questioned prompting a search for an alternative treatment option. Cyclic AMP has been shown invitro to act in synergy with progesterone to maintain uterine quiescence.</p><p><strong>Methods: </strong>We undertook an open label randomised feasibility study to test the hypothesis that the addition of aminophylline to the standard of care (SoC) is acceptable and can be tolerated in pregnant women at high risk of spontaneous preterm labour (sPTL). Women at high risk of sPTL, who met the inclusion criteria were invited to participate and randomised to receive the SoC (progesterone alone, n = 33) or treatment with the SoC and aminophylline (n = 37). The main outcome measure was to assess the how many women at high-risk of sPTL tolerated and continued to take aminophylline. Data were analysed using Graphpad Prism 8.0c (Graphpad Software, San Diego, CA, USA).</p><p><strong>Results: </strong>We found that of the addition of aminophylline was well tolerated in 30 of the 33 (91%) of women who continued in the combined arm, without any additional adverse maternal or fetal outcomes. 58% of eligible women agreed to participate in the study. The compliance rate was high at 99.42% +-0.82%. 67% of the women completed the post study questionnaire and all stated their willingness to take aminophylline if it were offered routinely for the prevention of sPTL.</p><p><strong>Conclusions: </strong>The addition of aminophylline to the SoC is acceptable to women at high-risk of sPTL confirming that a randomised trial of aminophylline to reduce preterm delivery in women at high-risk of PTL is feasible.</p><p><strong>Trial registration: </strong>Clinical trial gov NCT03152942. Date of full registration: 15/5/2017. https://clinicaltrials.gov/ct2/show/NCT03152942?cond=NCT03152942%26;draw=2%26;rank=1 .</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"357"},"PeriodicalIF":2.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of breastfeeding self-efficacy in the relationship between perinatal depressive symptoms and exclusive breastfeeding: a longitudinal mediation analysis.","authors":"Li Liu, Shuya Feng, Yu Zhang, Gui Xiao, Mengjia Zhou, Xingxing Li, Ying Li, Chunxiang Qin","doi":"10.1186/s12884-025-07481-8","DOIUrl":"10.1186/s12884-025-07481-8","url":null,"abstract":"<p><strong>Background: </strong>Perinatal depressive symptoms are associated with exclusive breastfeeding; however, the longitudinal mediating process of this relationship remains unclear. Breastfeeding self-efficacy may be an important variable in understanding the complex process involved in their co-occurrence. Therefore, we aimed to explore the role of breastfeeding self-efficacy in the relationship between perinatal depressive symptoms and exclusive breastfeeding using both between- and within-person approaches.</p><p><strong>Methods: </strong>A prospective longitudinal study was conducted from October 2021 to January 2024 at a tertiary hospital in Hunan, China. Depressive symptoms were measured at 36 gestational weeks and 1 week, 6 weeks, 3 months, and 6 months postpartum. Exclusive breastfeeding and breastfeeding self-efficacy were evaluated at the same postpartum intervals. Cross-lagged panel models, random intercepts cross-lagged panel models, and longitudinal mediation models were used to analyze their relationships.</p><p><strong>Results: </strong>A total of 334 participants were included. Longitudinal mediation models revealed that breastfeeding self-efficacy mediated the prospective negative effect of perinatal depressive symptoms on exclusive breastfeeding at the between-person level (b = - 0.017, SE = 0.008, 95% CI (- 0.032, - 0.001), P = 0.036), and suppressed the positive effect of exclusive breastfeeding on depressive symptoms at the within-person level (b = - 0.044, SE = 0.022, 95% CI (- 0.087, 0.000), P = 0.047).</p><p><strong>Conclusions: </strong>Mothers with perinatal depressive symptoms may face challenges in exclusive breastfeeding due to reduced breastfeeding self-efficacy. While increasing exclusive breastfeeding might help reduce depressive symptoms over time, this positive effect can be hindered if breastfeeding self-efficacy remains low. Our findings highlight breastfeeding self-efficacy as a critical target for future interventions.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"356"},"PeriodicalIF":2.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cefazolin versus placebo for surgical antibiotic prophylaxis in low-risk cesarean delivery: a feasibility blinded randomized controlled trial.","authors":"Victoria A Eley, Severine Navarro, Elizabeth Martin, Akwasi Amoako, Gunter Hartel, Christine Woods, Yan Lu, Jeffrey Lipman, Jason Roberts, Mimi Tang, Leonie Callaway","doi":"10.1186/s12884-025-07484-5","DOIUrl":"10.1186/s12884-025-07484-5","url":null,"abstract":"<p><strong>Background: </strong>Pre-incisional antibiotics are recommended for all patients having cesarean delivery, despite emerging concerns regarding effects on the infant. In this feasibility blinded randomized controlled trial we aimed to test research processes in low-risk women receiving cefazolin or placebo prior to elective cesarean delivery.</p><p><strong>Methods: </strong>The trial was prospectively registered (ACTRN12619001705178). Eligible women were aged ≥ 18 and < 40 years, ≥ 37 weeks gestation, at low risk of surgical site infection (SSI) and recruited from a single tertiary centre. We reported proportions of women eligible and consenting; adherence to perioperative infection prevention; blinding adequacy of staff using Bang's blinding index; SSI surveillance and diagnosis according to the Centre for Disease Control definitions and patient reported outcome measures using validated questionnaires up to 90 days.</p><p><strong>Results: </strong>We screened 1651 women, with 1245 (75%) ineligible based on body mass index or presence of diabetes. Of 287 eligible women, 30 were randomized (11%) with 15 in each group. Reasons for non-participation included \"wanting antibiotics\" (68, 27%), \"no reason\" (62, 25%) and lack of research staff (33, 13%). Compliance with perioperative infection prevention occurred in 5 of 7 steps. Spontaneous placental separation occurred in 25 (83%) and Comfeel dressing in 29 (97%). Blinding was adequate for all staff groups. SSI surveillance occurred in 156 of 210 (74%) timepoints. SSI occurred in two patients who received pre-incisional cefazolin and were successfully treated as outpatients. Patient reported outcome questionnaires were completed at 136 of 180 (76%) timepoints. There was no difference in maternal health-related quality of life between the groups.</p><p><strong>Conclusions: </strong>Feasibility was impacted by the high-risk population and patient desire for antibiotics. Adherence to perioperative infection prevention practices were high but incomplete. These study processes could be effectively applied in a larger population, targeting low risk maternity patients.</p><p><strong>Trial registration: </strong>Prospectively registered 4/12/2019 with the Australian New Zealand Clinical Trials Registry (ACTRN12619001705178).</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"353"},"PeriodicalIF":2.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}