Association between late pregnancy A/G ratio and the risk of neonatal admission for neonatal hyperbilirubinemia.

Objective: To investigate the association between late pregnancy A/G (Albumin to globulin) ratio and the risk of admission for neonatal hyperbilirubinemia (NHB).

Methods: This cross-sectional study selected mothers in labor and their newborns delivered at Nanjing Lishui People's Hospital, from January to December 2022. Multivariate logistic regression was utilized to analyze the relationship between late pregnancy A/G ratio and the risk of admission for NHB.

Results: Out of 1432 pregnant women, 15.7% of newborns were admitted for NHB. Outcome 1: Dichotomizing the A/G ratio at 1.29, the risk of NHB admission decreased by 33% (95% CI: 0.46-0.97) for every 0.1 increase in A/G ratio < 1.29. Conversely, when the A/G ratio ≥ 1.29, the risk of NHB admission increased by 16% (95% CI: 1.01-1.32) for each 0.1 increase in A/G ratio. Outcome 2: When A/G ratio was categorized into three groups using thresholds of 1.15 and 1.40, the risk of NHB admission increased by 107% (95% CI: 1.17-3.66) for G1 and 60% (95% CI: 1.16-2.19) for G3, compared to G2.

Conclusion: Late pregnancy A/G ratio is closely associated with the risk of admission for NHB. A/G ratio within different ranges affects the risk of NHB in varying directions and to different extents. Monitoring the A/G ratio may help identify pregnancies at higher risk of NHB.