BMC Pregnancy and Childbirth最新文献

{"title":"High taurocholic acid concentration induces ferroptosis by downregulating FTH1 expression in intrahepatic cholestasis of pregnancy.","authors":"Wei-Jian Zeng, Hua-Jing Yang, Ying-Jie Gu, Meng-Nan Yang, Meng-Ru Sun, Sheng-Kai Cheng, Yan-Yan Hou, Wei Gu","doi":"10.1186/s12884-025-07143-9","DOIUrl":"https://doi.org/10.1186/s12884-025-07143-9","url":null,"abstract":"<p><strong>Background: </strong>Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disorder associated with pregnancy and is usually diagnosed based on high serum bile acid. However, the pathogenesis of ICP is unclear. Ferroptosis has been reported as an iron-dependent mechanism of cell death. Although the role of Ferritin Heavy Chain 1 (FTH1) in ferroptosis has been extensively studied in various diseases, its mechanism in ICP through ferroptosis is yet to be analyzed.</p><p><strong>Methods: </strong>Placental tissues from patients with ICP and healthy controls were employed to verify the expression of FTH1. Taurocholic acid (TCA)-induced HTR-8/SVneo cells were established as an in vitro model for ICP, and ferroptosis-related experiments were performed. In particular, HTR-8/SVneo cells with or without overexpressing FTH1 and HTR-8/SVneo cells with or without TCA induction were investigated to explore the relationship between FTH1 and ferroptosis during ICP in vitro, respectively.</p><p><strong>Results: </strong>FTH1 was significantly downregulated in the ICP group compared with the control group. Furthermore, FTH1 and ferroptosis-related protein levels were downregulated, while the intracellular iron, reactive oxygen species, and lipid peroxidation levels were upregulated in the TCA-induced HTR-8/SVneo cells. In contrast, ferroptosis was inhibited by overexpression of FTH1 in TCA-induced HTR-8/SVneo cells.</p><p><strong>Conclusions: </strong>A high concentration of TCA in HTR-8/SVneo cells decreased the expression of FTH1. Overexpression of FTH1 could prevent cell death from ferroptosis induced by TCA. Thus, inhibiting the downregulation of FTH1 could be a potential therapeutic target for ICP treatment.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"21"},"PeriodicalIF":2.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of dance on maternal childbirth: a systematic review and meta-analysis.","authors":"Luping Zhang, Ru Yue, Feng Xiao, Fulan Wang, Zhiwei Zhang","doi":"10.1186/s12884-024-07132-4","DOIUrl":"https://doi.org/10.1186/s12884-024-07132-4","url":null,"abstract":"<p><strong>Background: </strong>Previous guidelines have clearly stated that dance is safe and beneficial during pregnancy and for childbirth. However, due to the small sample size of individual studies and different interventions, there were inconsistencies about the effect of dance on maternal childbirth.</p><p><strong>Methods: </strong>We included studies evaluating the effect of dance on women in labor. Risk of bias was assessed using the revised Risk of bias assessment tool for randomized controlled trials (RCTs). Data analyses was performed using Review Manager Software version 5.4.</p><p><strong>Results: </strong>A total of 12 RCTs comprising 1,486 pregnant women were included in the analysis. We found that the rate of natural childbirth and satisfaction with delivery were higher in the dance group than in the control group.The pain at 30 min and at 60 min after the intervention were lower in the dance group than in the control group. Meanwhile, the duration of the first stage, the second stage and the total labor duration was shorter in the dance group than in the control group.However, there were no statistically significant differences in the pain at 90 min after intervention, the duration of the third stage, and the rate of the normal 1-minute Apgar scores > 7 points between the two groups.</p><p><strong>Conclusions: </strong>Dance during labor could reduce labor pain to an extent, shorten the duration of labor, promote natural childbirth, and improve satisfaction with labor, with no adverse effects on neonatal outcomes.</p><p><strong>Trial registration: </strong>The protocol for this review was prospectively registered in the international prospective register of systematic reviews (PROSPERO) under the registration number CRD42022351001.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"20"},"PeriodicalIF":2.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Breastfeeding support as predictors of sustainable breastfeeding practices of nursing mothers with common mental disorders in tertiary hospital nurseries in Nigeria: a cross sectional study.","authors":"Michael Abel Alao, Olayinka Rasheed Ibrahim, Sakiru Abiodun Yekinni, Sikirat Adetoun Sotimehin, Udochukwu Michael Diala, Datonye Christopher Briggs, Aishatu Zaidu Musa, Zainab Oluwatosin Imam, Esther Oluwatoyin Famutimi, Adedeji Abiodun Idris, Adaeze C Ayuk, Kenechukwu Kosisochukwu Iloh, Chioma Laura Odimegwu, Ayomide Toluwanimi Adeyemi, Patricia F Medupin, Yetunde C Adeniyi, Kenechi Ogbodo Nnamani, Olukemi Oluwatoyin Tongo","doi":"10.1186/s12884-024-07126-2","DOIUrl":"https://doi.org/10.1186/s12884-024-07126-2","url":null,"abstract":"","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"23"},"PeriodicalIF":2.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Fetal echocardiographic parameters in pregnancies complicated by diabetes: a case control study.","authors":"Amal Darwish, Maged Abdel-Raouf, Rasha Kamel, Emad Salah, Mai Salah, Ahmed Okasha","doi":"10.1186/s12884-024-07016-7","DOIUrl":"https://doi.org/10.1186/s12884-024-07016-7","url":null,"abstract":"","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"19"},"PeriodicalIF":2.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intervention strategies to prevent mental health problems and improve resilience in employed parents from conception until the child is 5 years of age: a scoping review.","authors":"Neeltje Crombag, Bieke Bollen, Eline Vancoppenolle, Thomas Vandendriessche, Dagmar Versmissen, Martha Paisi, Jill Shawe, Susan Garthus-Niegel, Annick Bogaerts","doi":"10.1186/s12884-024-07043-4","DOIUrl":"https://doi.org/10.1186/s12884-024-07043-4","url":null,"abstract":"<p><strong>Aim: </strong>To understand the extent and type of evidence in relation to the effectiveness of intervention strategies targeting working pregnant women, and their partners, for the prevention of mental health problems (depression, anxiety) and improving resilience, from conception until the child is 5 years of age.</p><p><strong>Methods: </strong>A scoping review was conducted searching Pubmed (including Medline), Embase, Web of Science Core Collection and Scopus. Inclusion criteria were based on population (employed parents), context (from -9 months to 5 years postpartum) and concept (mental health problems, resilience and prevention/ preventative interventions).</p><p><strong>Results: </strong>Of the 17,699 papers screened, 3 full text papers were included. Studies focused on intervention strategies for working parents which showed a relationship with a reduction in mental health problems (depression and/or anxiety). The intervention strategies extracted from the literature referred to 'social support'. Social support provided by both the social and the work environment correlated with prenatal stress and depressive symptoms in the postpartum period, and supports a healthy work-family balance.</p><p><strong>Conclusion: </strong>Social support seems to have a positive association with the reduction of mental health problems. However, there are still important gaps in the literature such as a lack of RCT designs to test effectiveness of interventions and systematic reviews. Findings from this study may provide a roadmap for future research to close these gaps in knowledge.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"17"},"PeriodicalIF":2.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaginal colonization and vertical transmission of Candida species: prevalence and associated factors among pregnant women and their neonates at public health facilities of Northeast Ethiopia.","authors":"Alemu Gedefie, Getnet Shimeles, Hilina Motbainor, Brhanu Kassanew, Chalachew Genet","doi":"10.1186/s12884-024-07103-9","DOIUrl":"https://doi.org/10.1186/s12884-024-07103-9","url":null,"abstract":"<p><strong>Background: </strong>Vaginal colonization by Candida can lead to vulvovaginal candidiasis, which is the second most prevalent vaginal condition globally. It is frequently associated with sepsis and adverse neonatal outcomes in pregnant women. This issue is worsening in Sub-Saharan Africa, including Ethiopia. However, evidence of the existing problem is very scarce yet crucial. Thus, this study aimed to determine the vaginal colonization and vertical transmission of Candida species and their associated factors among pregnant women and their neonates in public health facilities of northeast Ethiopia.</p><p><strong>Methods: </strong>A facility-based cross-sectional study was conducted at selected public health facilities in Dessie town from April 1 to June 30, 2023, among 348 pregnant women and their newborns, using convenience sampling techniques. Socio-demographic, and clinical-related data were collected using a pre-tested, semi-structured questionnaire. Vaginal swab samples from pregnant women and pooled swabs from the external ear, nasal area, and umbilical areas of the newborns were collected and transported using Amies transport media. The samples were inoculated into Sabouraud Dextrose Agar for isolation, followed by inoculation onto a standard CHROM agar Candida plate for species identification, and a germ-tube test confirmed pseudophyphae of C.albicans. Data was entered into Epi Data version 4.6.0 software and exported and analyzed by SPSS version 25.0. A stepwise logistic regression model was used to identify the associated factors. Variables with p < 0.05 and their 95% confidence interval were considered statistically significant.</p><p><strong>Result: </strong>A total of 348 pregnant women attending vaginal delivery were included in the study. The maternal and neonatal colonization rates of Candida species were 14.1% (49/348) and 6.3% (22/348), respectively. The overall proportion of vertical transmission of Candida species was 44.9% (22/49, 95% CI: 41.2, 49.7). Among Candida isolates, 63.3% (31/49) were C. albicans and 36.7% (18/49) were C. krusei. Gestational diabetes mellitus (AOR: 4.2, 95% CI: 1.23-38.6, P = 0.047) and HIV (AOR: 1.58, 95% CI: 1.11-6.12, P = 0.049) were independently associated with maternal colonization of Candida species. Moreover, rural residence (AOR = 3.6, 95% CI: 1.37-9.5, P = 0.010) and maternal age above 28 years (AOR = 2.39, 95% CI: 1.97-5.89, P = 0.048) were independently associated with vertical transmission of Candida species.</p><p><strong>Conclusion: </strong>The findings of this study highlight the need for effective screening and treatment of Candida colonization during antenatal care.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"22"},"PeriodicalIF":2.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mediating role of coping style in the relationship between fear of childbirth and psychological birth trauma among natural childbirth women in China: a structural equation model analysis.","authors":"Ying Wang, Cuiping Liu, Yujie Sun, Yaqing Yuan, Liping Chen","doi":"10.1186/s12884-025-07146-6","DOIUrl":"https://doi.org/10.1186/s12884-025-07146-6","url":null,"abstract":"<p><strong>Background: </strong>Psychological birth trauma represents a significant global public health concern, with an estimated 45% of new mothers reporting such an experience. Researchers mostly focus on the impacts of postpartum mental health issues, such as postpartum post-traumatic stress disorder, minimal attention has been given to the antecedents of psychological birth trauma. This study seeks to investigate the correlation between fear of childbirth and psychological birth trauma among Chinese women who have undergone natural childbirth, as well as the mediating role of coping styles in the association between fear of childbirth and psychological birth trauma.</p><p><strong>Methods: </strong>This cross-sectional study was conducted among 420 women who underwent natural childbirth between June and December 2021 in Shandong Province, China. Data were gathered using the Wijma Delivery Experience Questionnaire, Trait Coping Style Questionnaire, and Impact of Event Scale-Revised. The structural equation model (SEM) was employed to examine the relationships between variables and to develop the final model.</p><p><strong>Results: </strong>The prevalence of psychological birth trauma among women who had experienced natural childbirth was recorded at 10.27%. The mean score and standard deviation of psychological birth trauma, fear of birth, positive coping (PC), and negative coping (NC) among these women were 19.7 ± 12.5, 76.9 ± 21.3, 35.66 ± 7.05, and 28.20 ± 7.99, respectively. Findings indicated that women's fear of childbirth was directly (B = 0.340, p = 0.001) and indirectly (B = 0.124, p = 0.001) linked to women's psychological birth trauma. Additionally, women's PC was negatively associated with psychological birth trauma (B= -0.352, p = 0.001), while NC was positively associated with psychological birth trauma (B = 0.199, p = 0.001).</p><p><strong>Conclusions: </strong>Chinese women who experienced natural childbirth encountered a moderate level of psychological birth trauma. Women's coping style plays a pivotal mediating role in the connection between fear of childbirth and psychological birth trauma. Consequently, interventions aimed at diminishing women's fear of childbirth and enhancing PC skills should be devised and implemented to alleviate women's psychological birth trauma.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"18"},"PeriodicalIF":2.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpected placenta accreta spectrum in an unscarred uterus causing catastrophic post-partum hemorrhage: a case report and review of the literature.","authors":"Priyanka Garg, Shweta Semwal, Romi Bansal","doi":"10.1186/s12884-025-07140-y","DOIUrl":"https://doi.org/10.1186/s12884-025-07140-y","url":null,"abstract":"<p><strong>Background: </strong>Placenta accreta spectrum (PAS) disorder is a fatal condition responsible for obstetric haemorrhage, which contributes to increased feto-maternal morbidity and mortality. The main contributing factor is a scarred uterus, often from a previous cesarean delivery, myomectomy, or uterine instrumentation. The occurrence of PAS in an unscarred uterus is extremely rare, with only anecdotal cases reported so far in the literature. We document one such case of unexpected placenta increta without identifiable risk factors presenting with severe postpartum hemorrhage. The management is often challenging, especially in low-middle-income countries like India with limited access to healthcare, where most cases are identified only at the time of delivery.</p><p><strong>Case presentation: </strong>We narrate a case of a 25-year-old woman of North Indian ethnicity, para 2 live 2, who presented to our emergency in shock with retained placenta and severe postpartum haemorrhage. She had undergone a normal vaginal delivery at 37 weeks and 2 days of pregnancy at a local hospital around 2 h before. The patient had not undergone antenatal checkups or sonography during her pregnancy. Manual removal of the placenta was attempted under anaesthesia, which was unsuccessful. So, keeping the diagnosis of the morbidly adherent placenta in mind and the deteriorating condition of the patient, an emergency laparotomy followed by a supracervical hysterectomy was performed after the conservative methods failed to control the haemorrhage. Simultaneously, she was given four units of packed red cells and fresh frozen plasma in a ratio of 1:1, along with vasopressors and fluid replacement therapy to attain hemodynamic stability. Post-operatively, the patient was shifted to the intensive care unit (ICU) for close monitoring. She was discharged after five days in satisfactory condition. A histopathological examination later on revealed placenta increta.</p><p><strong>Conclusion: </strong>Although very rare, PAS in an unscarred uterus with no other known risk factors is associated with a significant rate of maternal morbidity and mortality. This case highlights the importance of screening for radiological signs of adherent placenta during prenatal visits, even in low-risk populations. Any patient suspected of PAS should be referred to a well-equipped centre for optimal care. Also, young obstetricians should be imparted skill-based training to manage such emergencies with a multidisciplinary team approach.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"14"},"PeriodicalIF":2.8,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of E-learning clinical management of substance-dependent pregnant women on the knowledge and clinical skill performance of midwives: a randomized controlled trial.","authors":"Hasti Heidarian, Manoosh Mehrabi, Parvin Ghaemmaghami, Roksana Janghorban","doi":"10.1186/s12884-024-07130-6","DOIUrl":"https://doi.org/10.1186/s12884-024-07130-6","url":null,"abstract":"<p><strong>Background: </strong>Drug use during pregnancy and post-partum undoubtedly significantly affects maternal and infant morbidity. Healthcare providers, especially midwives who care for pregnant and postpartum women, must possess adequate knowledge and clinical skills to manage their patients appropriately. This study aimed to determine the effect of an e-learning intervention on midwives' knowledge and clinical performance skills in caring for substance-dependent pregnant women during labor and post-partum.</p><p><strong>Methods: </strong>A randomized controlled trial based on e-learning was conducted in Shiraz, Iran. One hundred midwives working in governmental maternity hospitals were recruited and randomly assigned to the intervention (n = 50) or control (n = 50) group through blocked randomization. The intervention group underwent e-learning for 4 weeks on clinical considerations during labor and post-partum of substance-dependent mothers. The control group received no educational intervention from the research group. Pre-test, post-test, and one-month retention tests included a knowledge assessment questionnaire and an objective structured clinical examination test to assess clinical skill performance in both groups. The data were analyzed using SPSS 16 software at a significance level of P < .05. Analysis of variance with repeated measures was used to compare the mean data between and within the groups.</p><p><strong>Results: </strong>A total of 93 midwives with a mean age of 36.78 ± 8.06 years were recruited and randomly assigned to the control group (n = 47) and the intervention group (n = 46). Seven midwives dropped out for different reasons. Immediately after and one month after the intervention, both the level of knowledge and the level of clinical skill performance of the midwives in the intervention group increased compared to those before the intervention (P < .001) and compared to those in the control group (P < .001). The knowledge of the intervention group in the one-month retention test was significantly reduced compared to that immediately after the intervention (P < .001), but clinical skill performance in the intervention group at one month after the intervention was not significantly different from that immediately after the intervention (P = 1.00).</p><p><strong>Conclusions: </strong>E-learning about clinical considerations during labor and post-partum in substance-dependent mothers can be an effective way to improve midwives' knowledge and clinical skill performance. Although knowledge decreased one month after training, clinical skill performance improved.</p><p><strong>Trial registration: </strong>http://www.irct.ir/ , IRCT20180928041164N1 registered November 13, 2018.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"11"},"PeriodicalIF":2.8,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The newborn behavioural observations (NBO) system embedded in routine postpartum care in at-risk families in Iceland: a randomised controlled trial.","authors":"Lisbeth Valla, Kari Slinning, Tore Wentzel-Larsen, Gun-Mette Røsand, Stefanía Birna Arnardóttir","doi":"10.1186/s12884-024-07128-0","DOIUrl":"https://doi.org/10.1186/s12884-024-07128-0","url":null,"abstract":"<p><strong>Background: </strong>The Newborn Behaviour Observation system (NBO) is a flexible relationship-based intervention designed to sensitise parents to their newborn's capacities, to increase parental confidence and foster the bond between parent and infant. The aim of this study was to investigate the effects of an NBO intervention on maternal confidence during the first month postpartum, and on the quality of mother-infant interaction at infant age 4 months in a sample of mothers who exhibit elevated signs of distress or depression during pregnancy and/or describe prior experiences of mental health issues.</p><p><strong>Method: </strong>Pregnant women with current emotional distress and/or a history of anxiety and depression were recruited from a healthcare centre in Reykjavik, between August 2016 and April 2018. The study used a two-group, randomised trial design with six measuring points, in which 54 women were randomly assigned to either the intervention or control group. The intervention group (n = 26) received the NBO in combination with standard care during routine home visits. The control group (n = 28) received the same numbers of home visits with standard care without NBO. Maternal confidence was measured using a parent questionnaire (covering learning outcomes relating to the infant's communicative signals and maternal confidence) administered after each home visit in weeks 2, 3 and 4 postpartum. At 4 months infant age, a free-play situation involving mother-infant interaction was video-recorded in the participants' homes and coded using the Emotional Availability Scale (EAS). Mixed effects models were used to estimate group differences in learning outcomes and maternal confidence across three time points. Two sample t-tests were used to compare the two groups' EAS scores.</p><p><strong>Results: </strong>The mothers in the intervention-group reported significantly higher maternal confidence and increased knowledge about their infant compared to the control group. Adjusted analyses suggest some evidence of a higher EAS non-hostility score in the intervention group (p = .031), but not for the other EAS scale scores (p ≥ .118).</p><p><strong>Conclusion: </strong>Early home visits combining NBO with standard care enhance maternal confidence and the mother's understanding of her infant. The small sample size makes it difficult to conclude whether repeated NBO sessions during the first month increase dimensions of maternal sensitivity in mother-infant interaction at 4 months postpartum.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov ID NCT04739332, Registered 02/01/2021.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"13"},"PeriodicalIF":2.8,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}