BMC Pregnancy and Childbirth最新文献

{"title":"The association between visceral fat accumulation caused by high-dose folic acid supplementation in the first trimester and gestational diabetes mellitus: protocol for a nested case-control study in a cohort study.","authors":"Hong Wang, Zhanhui Du, Xueteng Ding, Caiping Xiang, Min Cao, Yanfang Li, Guoju Li","doi":"10.1186/s12884-025-08174-y","DOIUrl":"https://doi.org/10.1186/s12884-025-08174-y","url":null,"abstract":"","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"1126"},"PeriodicalIF":2.7,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of pregnancy complicated by caroli disease.","authors":"Weiwei Wang, Xiaoteng Qiang, Xiufen Cai, Qing Bai","doi":"10.1186/s12884-025-08237-0","DOIUrl":"https://doi.org/10.1186/s12884-025-08237-0","url":null,"abstract":"<p><p>This study reports a rare case of Caroli disease (CD) combined with pregnancy, and analyses and discusses the etiology, differential diagnosis, clinical treatment of CD, and its special characteristics during pregnancy; this study suggests that medical and surgical comorbidities occurring during pregnancy should be given due attention, and the possibility of congenital intrahepatic bile duct structural abnormality should be identified, with a view to providing more insights into the diagnosis of CD and improving the level of obstetricians and gynaecologists' diagnosis and treatment of this rare disease, in order to timely diagnose and aggressively treat it, thereby improving maternal and infant outcomes. This study suggests that the possibility of congenital intrahepatic bile duct structural abnormalities should be identified in order to provide more insights into the diagnosis of CD and to improve the diagnosis of this rare disease by obstetricians and gynaecologists, so that timely diagnosis and proactive treatment can be made to improve the outcome of mother and child.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"1127"},"PeriodicalIF":2.7,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the impact of fetal growth restriction using high-resolution MRI: a comprehensive cortical analysis.","authors":"Shijie Huang, Lingnan Kong, Shuwei Bai, Qi Xu, Kai Zhang, Xuan Zhang, Geng Chen, Meng Zhao","doi":"10.1186/s12884-025-07746-2","DOIUrl":"10.1186/s12884-025-07746-2","url":null,"abstract":"<p><strong>Background: </strong>Fetal Growth Restriction (FGR) is a complex neurodevelopmental condition marked by the failure of a fetus to reach its genetically determined growth potential, leading to significant neurodevelopmental risks. Emerging MR scans exhibit superiority to traditional US-based diagnostic approaches, while quantitative morphological analysis of FGR is still lacking.</p><p><strong>Methods: </strong>This study explores the effects of FGR on fetal brain development using advanced Magnetic Resonance Imaging (MRI) techniques. A comprehensive analysis of 35 brain regions was conducted, focusing on detailed cortical properties such as curvature, sulcal depth, surface area, cortical gray matter volume, and cortical thickness, while distinguishing between the left and right hemispheres. Our comprehensive analysis leverages super-resolution reconstruction, segmentation, and surface reconstruction algorithms to obtain statistical data.</p><p><strong>Results: </strong>Our analysis revealed that (1) FGR equally affected both brain hemispheres; (2) In the absence of differentiation between brain regions, different cortical metrics had no significant effect on FGR; and (3) the most significant cortical metrics were primarily observed in cortical thickness and sulcal depth; (4) a regression model based on only seven key brain regions could effectively predict FGR. The findings demonstrate the value of high-resolution MRI in detecting early biomarkers for FGR, paving the way for improved prenatal care and targeted therapeutic strategies.</p><p><strong>Conclusions: </strong>The findings highlight the importance of high-resolution MRI in identifying early biomarkers for FGR. The study emphasizes the value of advanced cortical analysis in understanding the pathophysiological mechanisms underlying FGR and offers a robust framework for early diagnosis and intervention. These insights could contribute to improved prenatal care and targeted therapeutic strategies, ultimately enhancing outcomes for affected populations.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"1115"},"PeriodicalIF":2.7,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12539115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and predictors of dystocia during the active first stage of labor among mothers at Debre Markos Comprehensive Specialized Hospital, Amhara, Northwest Ethiopia.","authors":"Tirusew Nigussie Kebede, Getnet Azanaw, Muhabaw Shumye Mihret","doi":"10.1186/s12884-025-08192-w","DOIUrl":"10.1186/s12884-025-08192-w","url":null,"abstract":"<p><strong>Background: </strong>Dystocia of the active first stage of labor (AFSOL) significantly contributes to maternal and neonatal morbidity and mortality and is a major driver of rising cesarean delivery rates worldwide. Many determinants of AFSOL are potentially modifiable and context-specific, yet evidence from Ethiopia is limited.</p><p><strong>Objective: </strong>To assess the incidence and predictors of dystocia during the active first stage of labor among laboring women at Debre Markos Comprehensive Specialized Hospital, Northwest Ethiopia, 2022.</p><p><strong>Methods: </strong>A prospective follow-up study was conducted from October 20, 2022, to January 4, 2023, at Debre Markos Comprehensive Specialized Hospital, Northwest Ethiopia. A total of 656 laboring women were enrolled using systematic random sampling. Of these, 1.7% were lost to follow-up because cesarean delivery was performed before the completion of the active first stage of labor for reasons other than protracted or arrested cervical dilation. The remaining 94.5% of participants who completed follow-up were included in the analysis. Data were collected through direct observation, interviews using a pretested structured questionnaire, and medical record review. Data entry was done using Epi-data version 4.2, and analysis was performed with SPSS version 26. Descriptive statistics summarized participants' characteristics, and binary logistic regression was used to identify predictors of dystocia. Results were considered statistically significant at a p-value ≤ 0.05, and associations were reported as adjusted odds ratios (AOR) with 95% confidence intervals (CI).</p><p><strong>Results: </strong>The incidence of AFSOL dystocia was 35.3% (95% CI: 31.9-39.2). Positive predictors included induction of labor (AOR: 2.3; 95% CI: 1.09-4.91), admission with cervical dilation < 4 cm (AOR: 2.7; 95% CI: 1.62-4.63), poor provider support (AOR: 7.3; 95% CI: 4.06-13.39), and caffeine intake ≥ 200 mg/day ( ~ ≥ 3 cups; AOR: 3.4; 95% CI: 1.70-6.84). Protective factors included linseed consumption at labor onset (AOR: 0.25; 95% CI: 0.12-0.51), antenatal care follow-up (AOR: 0.24; 95% CI: 0.09-0.63), and ambulation during labor (AOR: 0.23; 95% CI: 0.09-0.54).</p><p><strong>Conclusion: </strong>The incidence of dystocia during the active first stage of labor is high. ANC follow-up, linseed consumption, and ambulation are protective, whereas caffeine intake, labor induction, early admission, and poor provider support increase risk. Implementing WHO labor care guidelines and promoting evidence-based provider practices may reduce dystocia and unnecessary interventions.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"1116"},"PeriodicalIF":2.7,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12538850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longer commute time is associated with a higher risk of miscarriage: a mixed-effects longitudinal study.","authors":"Ewa Jarosz, Chen Luo, Anna Matysiak","doi":"10.1186/s12884-025-08259-8","DOIUrl":"10.1186/s12884-025-08259-8","url":null,"abstract":"<p><strong>Background: </strong>Long commuting has been linked to some adverse pregnancy outcomes, but its association with miscarriage, one of the most common pregnancy complications, has not been investigated. This study examined whether the frequency and duration of commuting are associated with miscarriage risk.</p><p><strong>Methods: </strong>We used waves 1-11 (2008-2019) of the German Family Panel (Pairfam) and sampled women aged 16-45 who had a male partner, worked for pay, and reported a live birth or a miscarriage during the observation period. Cases of recurrent (3 or more) miscarriages were excluded. The final sample consisted of 579 women who reported 458 live births and 121 miscarriages. The association between commuting and miscarriage was examined using mixed effects logistic regression models, stepwise adjusting for work-related confounders.</p><p><strong>Results: </strong>Commute time longer than 20 min one-way was associated with an increased risk of miscarriage (OR 1.98; CI: 1.00-3.90) compared to commute time under 10 min, in the sample of all commuters. The risk was overall highest for those who commuted daily and for longer than 30 min one-way (OR: 2.28; CI: 1.05-4.98). Commute frequency alone was not associated with an increased risk, but there might be selection into sporadic or no commuting.</p><p><strong>Conclusions: </strong>A longer commute may represent a modifiable risk factor for miscarriage. Reducing commute time through home-based work, transport-related policies, or flexible scheduling to avoid peak hours could help mitigate this risk, particularly for women with an elevated baseline risk. Future studies should explore potential mechanisms linking commuting to adverse pregnancy outcomes, including stress, environmental exposures, and disruptions to circadian rhythms.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"1125"},"PeriodicalIF":2.7,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12542174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elective single morula transfer achieved better clinical outcomes than two cleavage embryos transfer in fresh IVF-ET cycles.","authors":"Qing Feng, Juan Liu, Zhiwei Zhou, Jinbao Ma, Yan Song, Zhaoxia Luo, Xiaohui Ye, Lang Shen","doi":"10.1186/s12884-025-08153-3","DOIUrl":"10.1186/s12884-025-08153-3","url":null,"abstract":"<p><strong>Background: </strong>Assisted reproductive technology (ART) effectively treats infertility yet often results in multiple pregnancies. Optimizing clinical pregnancy rates while minimizing multiples remains challenging. Key considerations for ART providers include embryo transfer timing, number, and developmental stage. While double cleavage-stage and single blastocyst transfers are common, limited data exists on the intermediate strategy of single morula transfer.</p><p><strong>Objective: </strong>This research aimed to assess whether elective single morula transfer (eSMT) on Day 4 yields clinical outcomes comparable to double cleavage-stage embryo transfer (DCT) on Day 3.</p><p><strong>Methods: </strong>A retrospective propensity-matched cohort study compared DCT and eSMT in IVF, with 156 matched cases per group. Primary outcomes included clinical pregnancy rate (CPR), live birth rate (LBR), twin pregnancy rate, and preterm delivery rate. Secondary outcomes were abortion rate (AR) and cesarean section rate.</p><p><strong>Results: </strong>After propensity score matching, no significant differences were observed between DCT and eSMT groups in CPR (75.00% vs. 69.23%), AR (16.24% vs. 14.81%), LBR (59.62% vs. 58.97%), or cesarean rate (51.61% vs. 41.30%) (all P > 0.05). The eSMT group showed significantly lower preterm delivery rates (9.78% vs. 21.51%, P < 0.05) and higher single live birth rates (58.97% vs. 43.59%, P < 0.01).</p><p><strong>Conclusion: </strong>In patients aged ≤ 35 years, Day 4 single morula transfer demonstrates clinical pregnancy rates comparable to Day 3 double cleavage-stage embryo transfer while reducing twin pregnancy and preterm labor risks, thereby providing a safe individualized treatment strategy.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"1121"},"PeriodicalIF":2.7,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12539196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invisible smoke, real threat: can education protect pregnant women from thirdhand smoke exposure? (a protocol study).","authors":"Nooshin Yoshany, Zohreh Karimiankakolaki, Mahsa Khodayarian, Sara Jambarsang, Amir Ghaderi, Zahra Afkhami","doi":"10.1186/s12884-025-08215-6","DOIUrl":"10.1186/s12884-025-08215-6","url":null,"abstract":"","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"1117"},"PeriodicalIF":2.7,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12539110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does vitamin B12 influence clinical pregnancy outcome in the follicular-phase GnRH agonist protocol?","authors":"Xiaoning Wang, Kui Fu, Ying Zhang, Shengfang Jiang, Changjun Zhang","doi":"10.1186/s12884-025-08250-3","DOIUrl":"10.1186/s12884-025-08250-3","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate whether vitamin B12 levels affect IVF-ET pregnancy outcomes.</p><p><strong>Design: </strong>Single-center, retrospective, observational study.</p><p><strong>Design: </strong>Single-center, retrospective, observational study.</p><p><strong>Main outcome measures: </strong>The primary outcome was the clinical pregnancy rate (CPR).</p><p><strong>Results: </strong>After adjusting for Age, BMI, AMH, number of oocytes retrieved, cleavage-stage embryos/blastocysts, and the number of transferred embryos, when the vitamin B12 value was ≤358.7 pg/ml, for every 10 pg/ml increase in the vitamin B12 value, the clinical pregnancy rate increased by 4% (OR=1.04, 95% CI=1.00, 1.08, P=0.03).</p><p><strong>Conclusion: </strong>Within a specific range (≤358.7 pg/mL), serum vitamin B12 levels may modestly contribute to improved clinical pregnancy rates in women undergoing IVF-ET with the follicular-phase GnRH agonist protocol, though further validation is required to confirm its clinical significance.</p><p><strong>Trial registration: </strong>None.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"1120"},"PeriodicalIF":2.7,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12538927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geospatial analysis of preterm and small-for-gestational age births in Washington D.C.","authors":"Alina Peluso, Kate Michel, Kristin L Atkins, Shannon Gopaul-Balser, Tara Gibbons, Rachel K Scott","doi":"10.1186/s12884-025-08039-4","DOIUrl":"10.1186/s12884-025-08039-4","url":null,"abstract":"","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"1123"},"PeriodicalIF":2.7,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12542157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative cystoscopy as a risk stratification tool for massive hemorrhage in placenta accreta spectrum.","authors":"Rosa F Drummond, Mevlut Bucak, Allison S Lankford, Mary Ellen Mangione, Katherine R Goetzinger, Ozhan M Turan","doi":"10.1186/s12884-025-08188-6","DOIUrl":"10.1186/s12884-025-08188-6","url":null,"abstract":"<p><strong>Background: </strong>We aimed to evaluate preoperative cystoscopies performed in the setting of PAS at our institution, and compare their correlation with blood loss, histological diagnosis, and surgical complications.</p><p><strong>Methods: </strong>We performed a retrospective review of patients with suspected PAS who underwent cystoscopy with ureteral stent placement at time of cesarean hysterectomy at a tertiary care center from 2018 to 2024. Inclusion criteria were scheduled cesarean hysterectomy, same surgeon, standardized surgical techniques, and availability of cystoscopy videos for review. Cystoscopies were reviewed for bulging, mucosal hyperemia (MH), MH around ureteral orifices (UOs), bridging blood vessels (BVs) with and without arterial pulsation, and distortion of trigone (DT.) Descriptive statistics were performed to evaluate for associations between cystoscopic variables and severe blood loss (SBL) over two liters, histologic grading, genitourinary tract injuries, REBOA use, and ICU admission. A p value < 0.05 was considered significant.</p><p><strong>Results: </strong>66 cases were included. Bulging was present in 73% of cases, MH in 61%, MH around UOs in 61%, BVs in 42%, arterial pulsation in 24%, and DT in 27%. 17 cases had SBL. The presence of BVs was significantly associated with SBL (n = 12, p = 0.009, OR 4.9 [95% CI: 1.49-16.47.]) DT was significantly associated with high grade lesions (n = 10, p = 0.02, OR 5.1 [95% CI 1.25-20.65]) and cystotomy (n = 8, p = 0.006, OR 6.11 [95% CI 1.67-22.41.]). There was presence of BVs in all cases of transfusion ≥ 4 units of pRBCs, both cases of REBOA use, and the one ICU admission. BVs were always on the lower posterior wall of the bladder.</p><p><strong>Conclusion: </strong>In this study, the finding of bridging blood vessels on the lower posterior wall of the bladder was associated with severe blood loss of over two liters. Preoperative cystoscopy can assist surgeons in identifying patients with low posterior bladder lesions who may benefit from cesarean hysterectomy and prepare for massive blood transfusion or REBOA use, as well as help counsel patients more clearly on expectations.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"1118"},"PeriodicalIF":2.7,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12538983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}