BMC Pregnancy and Childbirth最新文献

{"title":"Clinical impact of early-onset sepsis on outcomes of necrotizing enterocolitis: a retrospective case-control study.","authors":"Wei Feng, Jinping Hou, Xiaohong Die, Zhenhua Guo, Wei Liu, Xuan Zhai, Yi Wang","doi":"10.1186/s12884-026-09219-6","DOIUrl":"https://doi.org/10.1186/s12884-026-09219-6","url":null,"abstract":"<p><strong>Purpose: </strong>Early-onset sepsis (EOS) is a significant issue associated with high morbidity and mortality in newborns, yet it has not received adequate attention among neonatal necrotizing enterocolitis (NEC). This study aimed to investigate the clinical characteristics of NEC patients with EOS and to assess the association between EOS and NEC-related outcomes.</p><p><strong>Patients and methods: </strong>The retrospective case-control study included 196 NEC patients (Bell's stage ≥ II) admitted to a tertiary neonatal intensive care unit from January 2023 to March 2025. Of these, 98 patients with EOS were matched to 98 controls (without EOS) based on birth weight, gestational age, and gender. The medical records of eligible patients were reviewed, and the clinical characteristics were systematically analyzed. Statistical analyses were performed using R software.</p><p><strong>Results: </strong>The cohort included 196 patients, with a median gestational age of 32.1 weeks (IQR: 29.5, 34.4) and a median birth weight of 1615.0 g (IQR: 1227.5, 2050.0). Compared with the controls, cases showed significantly higher inflammatory markers (CRP and procalcitonin), lower platelet count, and higher incidences of hypoproteinemia, shock, and coagulopathy (all P < 0.05). Furthermore, ventilator support, blood transfusion, using of inotropes (dopamine), and Bell stage III were significantly more frequent among cases. Both the rate of surgical intervention [67.35% vs. 22.45%] and mortality [29.59% vs. 8.16%] were markedly elevated in the cases than in the controls. In multivariate conditional Logistic regression analysis, EOS emerged as an independent risk factor for both NEC-related surgical intervention [odds ratio (95% confidence interval) = 3.853 (1.724-8.612)] and death [odds ratio (95% confidence interval) = 5.017 (2.083-12.087)].</p><p><strong>Conclusion: </strong>The clinical characteristics of medical conditions identified in patients with EOS were distinct from those observed in patients without EOS. Moreover, EOS was associated with increased odds of NEC-related surgical intervention and mortality.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of low birth weight with infertility and ART treatment: single-center cohort analysis of 7697 singleton live births.","authors":"Yuanhui Chen, Hongwei Geng, Li Meng, Cuilian Zhang","doi":"10.1186/s12884-026-08980-y","DOIUrl":"https://doi.org/10.1186/s12884-026-08980-y","url":null,"abstract":"<p><strong>Background: </strong>Low birth weight (LBW) significantly influences neonatal prognosis as well as growth and development in adult. This study aimed to explore the increased risk of low birth weight (LBW) in singleton live births in connection with infertility treatment is attributed to patient- and cycle-dependent factors related to infertility or the use of ART procedures.</p><p><strong>Methods: </strong>This was a retrospective cohort study of 7697 patients with singleton live births of IVF/ICSI treatment between January 2016 and December 2020. We explored the increased risk of LBW and patient- and cycle-dependent factors to determine their influence on the likelihood of LBW. To analyze this relationship, we employed both univariate and multivariate logistic regression analyses.</p><p><strong>Results: </strong>LBW occurred in 5.81% out of 7697 singleton live births. The body mass index (BMI), endometrial thickness (EMT), number of transferred embryos, and vanishing multiple pregnancies were significantly associated with the LBW rate according to the univariate logistic regression analysis. After adjusting for confounding factors, overweight (BMI 24-27.9 kg/m²) and obese (BMI ≥ 28 kg/m2) patients had a significantly increased risk of LBW (OR = 1.421, 95% CI: 1.139-1.772, P = 0.002; OR = 1.470, 95% CI: 1.080-2.000, P = 0.014, respectively). and thicker EMT (≥ 8 mm) significantly decreased the LBW rate (P < 0.001). Furthermore, the presence of a multiple pregnancy was found to be correlated with an increased LBW rate (OR = 1.946, 95% CI 1.462-2.589, P < 0.001); the number of transferred embryos was not significantly associated with LBW (OR = 0.119, 95% CI 0.859-1.456, P = 0.405).</p><p><strong>Conclusions: </strong>Maternal BMI, EMT, and vanishing multiple pregnancies are important risk factors for LBW in single infants conceived through IVF. It is essential to consider pre-pregnancy maternal weight, endometrial thickness, and promote the practice of elective single embryo transfer .</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid function changes in pregnant women with thyroid cancer and their association with adverse fetal outcomes: a parallel controlled study.","authors":"Zhi-Fen Hua, Juan Chen, Jiang-Nan Wu, Ting Peng","doi":"10.1186/s12884-026-09222-x","DOIUrl":"https://doi.org/10.1186/s12884-026-09222-x","url":null,"abstract":"<p><strong>Background: </strong>The effects of thyroid hormone replacement or suppression therapy in women with thyroid cancer on thyroid function during pregnancy and subsequent adverse fetal outcomes are still largely unknown. To compare thyroid function at 8 weeks of gestation and its changes during pregnancy between the survivors and controls, and to assess the association of these differences with adverse fetal outcomes.</p><p><strong>Methods: </strong>This was a retrospective cohort-based parallel control study. A total of 140 survivors and 280 controls delivery time-matched controls were extracted from 46,610 singleton pregnant women who received prenatal examinations in a second-level specialized hospital between January 2019 and March 2024. The primary outcomes were birth defects, small for gestational age (SGA, defined as birth weight < 10th percentile by gestational week), preterm birth (< 37 weeks), and neonatal asphyxia (defined as fetuses with a 1 min-Apgar score of < 7). Apgar scores at 1 and 5 min and umbilical arterial blood gas (ABG) indexes were surrogate indicators of neonatal asphyxia.</p><p><strong>Results: </strong>Compared to the control group, FT3 was lower in the survivors, while FT4 was higher. Change of FT3 between 8 and 16 weeks of gestation in survivors was significantly smaller than that in the controls (-0.08 vs. -0.30, P < 0.005). The survivors had an insignificant association with SGA/preterm birth (adjusted OR 2.06, 0.68-6.23, P = 0.20), a slightly higher risk of fetal asphyxia (Peto OR, 6.49; 95% CI: 0.81-52.0; P = 0.078), and a lower 1 min Apgar score (β, -0.10; 95% CI: -0.16 to -0.03;P = 0.004). Change in FT3 between 8 and 16 weeks was associated with SGA/preterm birth (adjusted OR, 4.42, 95%CI: 1.32-14.84, P = 0.016). FT3 at 8 weeks of gestation and its changes between 16 and 32 weeks of gestation were negatively correlated with the umbilical ABG index, with both β of -0.02(p = 0.015 and 0.019, respectively).</p><p><strong>Conclusions: </strong>This study found differences in FT3 and FT4 levels and their changes during pregnancy between the survivors and controls. These differences, especially the changes in FT3 during pregnancy, might suggest a potential biological link, though further studies are needed to establish causality.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A nomogram integrating dynamic total bile acid monitoring, medication history, and curative effect for preterm birth prediction in twin pregnancies with intrahepatic cholestasis of pregnancy.","authors":"Fei Ding, Jia Li, Minjie Zhang, Yanhua Zhao, Shanshan Liang, Qianwen Zhang","doi":"10.1186/s12884-026-09089-y","DOIUrl":"https://doi.org/10.1186/s12884-026-09089-y","url":null,"abstract":"<p><strong>Objective: </strong>Intrahepatic cholestasis of pregnancy (ICP) complicated by twin pregnancy significantly increases the risk of preterm birth, and no tailored predictive tools for gestational age (GA) at delivery have been developed for this specific population to date. This study aimed to develop and validate a twin-specific nomogram with dynamic total bile acid (TBA) monitoring, medication history and curative effect for preterm birth prediction in this population.</p><p><strong>Methods: </strong>A retrospective cohort of 258 twin pregnancies complicated by ICP was enrolled (November 2024-November 2025). The data included demographic, clinical, biochemical (dynamic TBA parameters, liver enzymes), and therapeutic variables (ursodeoxycholic acid (UDCA) usage, combination regimens, TBA response posttreatment). LASSO regression was used to select predictors, which were incorporated into a logistic regression-based nomogram. The model was validated using discrimination (the area under the receiver operating characteristic curve (AUC)), classification accuracy (sensitivity, specificity, PPV, NPV), calibration (Hosmer-Lemeshow test, calibration curves), and clinical utility (decision curve analysis (DCA)).</p><p><strong>Results: </strong>In this cohort, the incidence of preterm birth was 83.3%. The independent predictors of preterm birth included GA at ICP diagnosis, UDCA usage, GA at TBA peak, TBA severity group at peak, predelivery TBA (TBA end), aspartate aminotransferase (AST), and treatment curative effect (all P < 0.05). The discriminatory performance of the nomogram, as measured by the area under the curve (AUC), was 0.812 (95% CI: 0.721-0.903) in the training set and 0.740 (95% CI: 0.590-0.889) in the test set. Calibration curves and Hosmer-Lemeshow tests (training set P = 0.1527; test set P = 0.6991) confirmed good agreement between the predicted and actual outcomes. DCA demonstrated significant net benefits across a clinically relevant risk threshold (0-0.833). The model exhibited high specificity (93.8%) and negative predictive value (85.7%) in the test set.</p><p><strong>Conclusion: </strong>To our knowledge, this is among the first nomograms for preterm birth prediction in twin pregnancies with ICP that integrate dynamic TBA monitoring and therapeutic variables. This model is intended primarily as a low-risk exclusion tool to support clinical monitoring strategies, rather than to guide high-risk prediction or delivery decisions. Notably, the model predicts a composite preterm birth outcome modified by both biological risk and clinical intervention rather than purely spontaneous preterm birth, and its low sensitivity further restricts its utility for high-risk preterm birth prediction. Its clinical utility for this purpose requires further rigorous prospective and future external validation studies.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Living with risk and uncertainty: a qualitative phenomenological study of women's pregnancy and postpartum experiences in Saskatchewan during COVID-19.","authors":"Daniel A Adeyinka, Brandace Winquist, Joanne Sivertson, Leah Thorp, Elora Lake, Mamata Pandey, Barb Sauve, Jessica R Campbell","doi":"10.1186/s12884-026-09224-9","DOIUrl":"https://doi.org/10.1186/s12884-026-09224-9","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic disrupted maternal healthcare globally, yet localized experiences within structurally constrained settings remain underexplored. In Saskatchewan, Canada, pre-existing inequities relating to geography and health care access shaped how women experienced pregnancy and early motherhood during the pandemic. This study explored the lived experiences of women who were pregnant and gave birth during the COVID-19 pandemic, with particular attention to how healthcare disruptions, social restrictions, and structural conditions shaped care experiences, distress, and resilience.</p><p><strong>Methods: </strong>This qualitative interpretive phenomenology study drew on 35 individual interviews and three focus group discussions with a total of 51 women who were pregnant or gave birth between March 2020 and December 2022. Participants were purposively sampled across urban, rural, and northern Saskatchewan. Data were analyzed using reflexive thematic analysis.</p><p><strong>Results: </strong>Four themes were identified: living with pandemic risk and uncertainty; fragmentation of maternal care; emotional toll of isolation; and coping and resilience. Women described heightened fear and moral responsibility, disrupted access to prenatal and postpartum services, depersonalized communication, and limited mental health and lactation support, particularly in rural and northern regions. While virtual care improved accessibility for some women, it often lacked relational and embodied dimensions of care. Family support, trusted healthcare providers, and digital resources facilitated coping and resilience.</p><p><strong>Conclusion: </strong>The pandemic intensified existing inequities in maternal healthcare, revealing vulnerabilities in communication, continuity, and culturally responsive care. Findings underscore the need for equity-oriented emergency preparedness, hybrid models of care, strengthened maternal mental health services, and meaningful involvement of people with lived experience in planning future responses.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lower oxidative balance score is linked to increased miscarriage risk: findings from a case-control study.","authors":"Amir Hossein Faghfouri, Samira Gholami, Amin Moakri-Yamchi, Negar Karimi, Shabnam Vazifekhah","doi":"10.1186/s12884-026-09056-7","DOIUrl":"https://doi.org/10.1186/s12884-026-09056-7","url":null,"abstract":"<p><strong>Background: </strong>Oxidative stress (OS) may play a role in adverse pregnancy outcomes, including spontaneous miscarriage. This study aimed to assess oxidative balance score (OBS), ranging from 0 to 38, and related characteristics in women with spontaneous miscarriage compared to healthy pregnant women.</p><p><strong>Methods: </strong>A case-control study was conducted at Kowsar Women's Hospital in Urmia, Iran, between June 2024 and March 2025. The case group included 152 women with spontaneous miscarriage, and the control group included 300 healthy pregnant women beyond 20 weeks' gestation. OBS, combining dietary and lifestyle antioxidant/pro-oxidant factors, was calculated and analyzed across tertiles.</p><p><strong>Results: </strong>Total OBS was significantly lower in the case group compared to controls (20.25 ± 7.19 vs. 22.45 ± 6.67; p = 0.023), while dietary OBS did not differ significantly (p = 0.15). Lifestyle OBS was lower in the miscarriage group (p < 0.001), with reduced physical activity and higher smoking prevalence. Magnesium, selenium, and vitamin B6 intakes were also significantly lower in the case group (p-values = 0.047, 0.034, 0.042, respectively); However, after applying Bonferroni correction for multiple comparisons (adjusted α = 0.0026), none of the nutrient-level associations remained statistically significant. Higher tertiles of total and lifestyle OBS were associated with lower odds of miscarriage after adjustment for confounders (OR = 0.46, 95%CI (0.21- 0.99) and OR = 0.41, 95%CI(0.19- 0.88), respectively), while dietary OBS remained non-significant.</p><p><strong>Conclusion: </strong>Lower total and lifestyle OBS are associated with an increased risk of spontaneous miscarriage. OBS may serve as a useful marker for miscarriage risk assessment.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the usage preferences and expectations of postpartum women regarding mobile applications developed for the postpartum period.","authors":"Burcu Dişli Oktar, Nazire Bahar, Ümran Oskay","doi":"10.1186/s12884-026-09117-x","DOIUrl":"https://doi.org/10.1186/s12884-026-09117-x","url":null,"abstract":"<p><strong>Background: </strong>The postpartum period is a critical time when women need information and support for both their own health and newborn care. Mobile health applications can significantly improve access to information during the postpartum period. However, the effectiveness of such applications depends on understanding postpartum women's usage preferences and expectations. Existing evidence on postpartum mobile health applications is largely derived from studies conducted in South Asian and East African contexts, highlighting the need for context-specific data from Türkiye. This study aimed to determine the usage preferences and expectations of postpartum women regarding mobile applications developed for the postpartum period.</p><p><strong>Methods: </strong>This descriptive study was conducted with 385 postpartum women in Istanbul, Türkiye. Data were collected between October 2024 and February 2025 using a structured Descriptive Information Form prepared by the researchers. The form included items related to sociodemographic characteristics, obstetric characteristics, and opinions regarding the use of mobile applications during the postpartum period. Data were analyzed using descriptive statistics, chi-square and multivariate logistic regression analysis.</p><p><strong>Results: </strong>Willingness to use mobile applications was significantly associated with age, educational level, income status, parity, and mode of birth. The most frequently requested application content included newborn care (45.5%), common newborn problems and their management (42.9%), and emergency situations related to maternal and newborn health (40.5%). Participants also emphasized the importance of applications providing reliable, clear, and up-to-date information.</p><p><strong>Conclusion: </strong>Postpartum women have specific preferences and expectations regarding mobile health applications designed for the postpartum period. Developing user-centered mobile applications that prioritize newborn care and emergency-related content may support postpartum health services and enhance maternal and newborn health outcomes.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Umbilical cord ulceration associated with placental abruption: a case report.","authors":"Yanqing Peng, Guannan He, Chuanju Zhang, Litao Sun, Jing Zhao","doi":"10.1186/s12884-026-09124-y","DOIUrl":"https://doi.org/10.1186/s12884-026-09124-y","url":null,"abstract":"<p><strong>Background: </strong>Umbilical cord ulceration (UCU) is a rare but potentially fatal obstetric condition characterized by ulcerative disruption of the umbilical cord, often leading to fetal hemorrhage and intrauterine fetal demise. Placental abruption, defined as the premature separation of the placenta from the uterine wall, is another major cause of perinatal mortality. When UCU is complicated by occult placental abruption, the risk of adverse perinatal outcomes increases substantially. These associations highlight the importance of vigilant prenatal surveillance and comprehensive imaging to facilitate early detection and timely intervention.</p><p><strong>Case presentation: </strong>We report a case involving a 33-year-old woman at 37 weeks and 5 days of gestation who presented with abdominal tightness and subjectively reduced fetal movements. Prenatal ultrasound and Color Doppler imaging (CDI) revealed umbilical cord abnormalities, including loss of Wharton's jelly and absent blood flow signals. An emergency cesarean section was promptly performed, resulting in favorable maternal and neonatal outcome. Postoperative pathological examination confirmed the diagnosis of UCU with hemorrhage, complicated by placental abruption.</p><p><strong>Conclusions: </strong>To our knowledge, this is the first reported case of UCU complicated by placental abruption. This case underscores the importance of considering UCU in the differential diagnosis of unexplained fetal distress in late pregnancy. Early recognition and timely intervention guided by prenatal imaging are essential for improving perinatal outcomes.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of second-trimester hematological and biochemical indicators in predicting preeclampsia: a retrospective study.","authors":"Lihua Dong, Fanzhen Hong, Juanyu Ma, Haijie Hong","doi":"10.1186/s12884-026-09206-x","DOIUrl":"https://doi.org/10.1186/s12884-026-09206-x","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Abnormalities in complete blood counts (CBCs), lipid profiles, and plasma glucose levels in the peripheral blood are associated with the development of preeclampsia (PE). However, the predictive value of these indicators for PE in the second trimester remains uncertain. This study aimed to investigate the predictive potential of hematological and biochemical indicators during the second trimester for PE.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective study was conducted involving 388 pregnant women with PE and 500 healthy pregnant women who delivered between January 2022 and June 2025. Basic information, including maternal age, prepregnancy body mass index (BMI), gravidity, and parity, was collected. Blood indicators, including CBCs, lipid profiles and fasting plasma glucose (FPG) levels, were measured at 20-24 weeks of gestation. The derived parameters were calculated from these indicators. Intergroup comparisons, logistic regression and restricted cubic spline analysis were used to evaluate the relationships between these indicators and the risk of PE. A predictive model and corresponding nomogram were subsequently constructed. Receiver operating characteristic (ROC) curve, calibration curve and decision curve analyses were used to evaluate the prediction model.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), white blood cell (WBC), monocyte, lymphocyte, neutrophil, platelet, plateletcrit (PCT), triglycerides (TG), nonesterified fatty acid (NEFA), and FPG levels were elevated in the PE group, while total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels were decreased. The derived parameters, including systemic immune-inflammation index (SII), pan-immune inflammation value (PIV), monocyte-to-HDL-C ratio (MHR), neutrophil-to-HDL-C ratio (NHR), lymphocyte-to-HDL-C ratio (LHR), atherogenic index of plasma (AIP), atherogenic coefficient (AC), Castelli-I, lipoprotein combined index (LCI), and triglyceride-glucose (TyG), were also significantly elevated in the PE group. After adjusting for confounding factors, MHR, NHR, LHR, AIP, AC, Castelli-I, LCI, and TyG were significantly associated with the risk of PE. As these derived parameters increased, the risk of PE also increased. However, the predictive performance of single derived parameters was modest [the areas under the curves (AUCs) ranged from 0.500 to 0.701]. The prediction model included prepregnancy BMI, RBC count, platelet count, NEFA, FPG, LHR, AC, TyG, and parity. This prediction model demonstrated favorable predictive performance and calibration ability, with an AUC of 0.815 (95% CI 0.787-0.843).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Hematological and biochemical indicators in the second trimester may serve as potential markers for PE. Integration of these indicators into routine prenatal care may facilitate early identification of high-risk pregnanc","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: The value of subcutaneous tissue closure and drain in obese women undergo elective caesarean section: a randomized controlled trial.","authors":"Mohamed A Shalaby, Hanan H M Metwally, Ahmed M Maged, Yomna A Bayoumi, Noha Salah","doi":"10.1186/s12884-026-09230-x","DOIUrl":"https://doi.org/10.1186/s12884-026-09230-x","url":null,"abstract":"","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"26 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}