Does vitamin B12 influence clinical pregnancy outcome in the follicular-phase GnRH agonist protocol?

IF 2.7 2区医学 Q1 OBSTETRICS & GYNECOLOGY

BMC Pregnancy and Childbirth Pub Date : 2025-10-21 DOI:10.1186/s12884-025-08250-3

Xiaoning Wang, Kui Fu, Ying Zhang, Shengfang Jiang, Changjun Zhang

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引用次数: 0

Abstract

Purpose: To investigate whether vitamin B12 levels affect IVF-ET pregnancy outcomes.

Design: Single-center, retrospective, observational study.

Main outcome measures: The primary outcome was the clinical pregnancy rate (CPR).

Results: After adjusting for Age, BMI, AMH, number of oocytes retrieved, cleavage-stage embryos/blastocysts, and the number of transferred embryos, when the vitamin B12 value was ≤358.7 pg/ml, for every 10 pg/ml increase in the vitamin B12 value, the clinical pregnancy rate increased by 4% (OR=1.04, 95% CI=1.00, 1.08, P=0.03).

Conclusion: Within a specific range (≤358.7 pg/mL), serum vitamin B12 levels may modestly contribute to improved clinical pregnancy rates in women undergoing IVF-ET with the follicular-phase GnRH agonist protocol, though further validation is required to confirm its clinical significance.

Trial registration: None.

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在卵泡期GnRH激动剂方案中，维生素B12是否影响临床妊娠结局？

目的：探讨维生素B12水平是否影响IVF-ET妊娠结局。设计：单中心、回顾性、观察性研究。设计：单中心、回顾性、观察性研究。主要观察指标：主要观察指标为临床妊娠率（CPR）。结果：在调整年龄、BMI、AMH、取卵数、卵分裂期胚胎/囊胚数、移植胚胎数等因素后，当维生素B12值≤358.7 pg/ml时，维生素B12值每增加10 pg/ml，临床妊娠率提高4% （OR=1.04, 95% CI=1.00, 1.08， P=0.03）。结论：在特定范围内（≤358.7 pg/mL），血清维生素B12水平可能有助于改善卵泡期GnRH激动剂方案的IVF-ET妇女的临床妊娠率，但需要进一步验证以确认其临床意义。试验注册：无。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Pregnancy and Childbirth OBSTETRICS & GYNECOLOGY-

CiteScore

4.90

自引率

6.50%

发文量

845

审稿时长

3-8 weeks

期刊介绍： BMC Pregnancy & Childbirth is an open access, peer-reviewed journal that considers articles on all aspects of pregnancy and childbirth. The journal welcomes submissions on the biomedical aspects of pregnancy, breastfeeding, labor, maternal health, maternity care, trends and sociological aspects of pregnancy and childbirth.