Xiaoning Wang, Kui Fu, Ying Zhang, Shengfang Jiang, Changjun Zhang
{"title":"在卵泡期GnRH激动剂方案中，维生素B12是否影响临床妊娠结局？","authors":"Xiaoning Wang, Kui Fu, Ying Zhang, Shengfang Jiang, Changjun Zhang","doi":"10.1186/s12884-025-08250-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To investigate whether vitamin B12 levels affect IVF-ET pregnancy outcomes.</p><p><strong>Design: </strong>Single-center, retrospective, observational study.</p><p><strong>Design: </strong>Single-center, retrospective, observational study.</p><p><strong>Main outcome measures: </strong>The primary outcome was the clinical pregnancy rate (CPR).</p><p><strong>Results: </strong>After adjusting for Age, BMI, AMH, number of oocytes retrieved, cleavage-stage embryos/blastocysts, and the number of transferred embryos, when the vitamin B12 value was ≤358.7 pg/ml, for every 10 pg/ml increase in the vitamin B12 value, the clinical pregnancy rate increased by 4% (OR=1.04, 95% CI=1.00, 1.08, P=0.03).</p><p><strong>Conclusion: </strong>Within a specific range (≤358.7 pg/mL), serum vitamin B12 levels may modestly contribute to improved clinical pregnancy rates in women undergoing IVF-ET with the follicular-phase GnRH agonist protocol, though further validation is required to confirm its clinical significance.</p><p><strong>Trial registration: </strong>None.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"1120"},"PeriodicalIF":2.7000,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12538927/pdf/","citationCount":"0","resultStr":"{\"title\":\"Does vitamin B12 influence clinical pregnancy outcome in the follicular-phase GnRH agonist protocol?\",\"authors\":\"Xiaoning Wang, Kui Fu, Ying Zhang, Shengfang Jiang, Changjun Zhang\",\"doi\":\"10.1186/s12884-025-08250-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To investigate whether vitamin B12 levels affect IVF-ET pregnancy outcomes.</p><p><strong>Design: </strong>Single-center, retrospective, observational study.</p><p><strong>Design: </strong>Single-center, retrospective, observational study.</p><p><strong>Main outcome measures: </strong>The primary outcome was the clinical pregnancy rate (CPR).</p><p><strong>Results: </strong>After adjusting for Age, BMI, AMH, number of oocytes retrieved, cleavage-stage embryos/blastocysts, and the number of transferred embryos, when the vitamin B12 value was ≤358.7 pg/ml, for every 10 pg/ml increase in the vitamin B12 value, the clinical pregnancy rate increased by 4% (OR=1.04, 95% CI=1.00, 1.08, P=0.03).</p><p><strong>Conclusion: </strong>Within a specific range (≤358.7 pg/mL), serum vitamin B12 levels may modestly contribute to improved clinical pregnancy rates in women undergoing IVF-ET with the follicular-phase GnRH agonist protocol, though further validation is required to confirm its clinical significance.</p><p><strong>Trial registration: </strong>None.</p>\",\"PeriodicalId\":9033,\"journal\":{\"name\":\"BMC Pregnancy and Childbirth\",\"volume\":\"25 1\",\"pages\":\"1120\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-10-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12538927/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMC Pregnancy and Childbirth\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12884-025-08250-3\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Pregnancy and Childbirth","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12884-025-08250-3","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Main outcome measures: The primary outcome was the clinical pregnancy rate (CPR).
Results: After adjusting for Age, BMI, AMH, number of oocytes retrieved, cleavage-stage embryos/blastocysts, and the number of transferred embryos, when the vitamin B12 value was ≤358.7 pg/ml, for every 10 pg/ml increase in the vitamin B12 value, the clinical pregnancy rate increased by 4% (OR=1.04, 95% CI=1.00, 1.08, P=0.03).
Conclusion: Within a specific range (≤358.7 pg/mL), serum vitamin B12 levels may modestly contribute to improved clinical pregnancy rates in women undergoing IVF-ET with the follicular-phase GnRH agonist protocol, though further validation is required to confirm its clinical significance.
期刊介绍：
BMC Pregnancy & Childbirth is an open access, peer-reviewed journal that considers articles on all aspects of pregnancy and childbirth. The journal welcomes submissions on the biomedical aspects of pregnancy, breastfeeding, labor, maternal health, maternity care, trends and sociological aspects of pregnancy and childbirth.
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