BMC Pregnancy and Childbirth最新文献

{"title":"Neonatal outcome in late preterm twin gestation: impact of antenatal corticosteroids therapy before 34 weeks.","authors":"Or Eliner, Efrat Dicker-Sagy, Hanoch Schreiber, Gal Cohen, Tal Biron-Shental, Michal Kovo","doi":"10.1186/s12884-025-07533-z","DOIUrl":"10.1186/s12884-025-07533-z","url":null,"abstract":"<p><strong>Background: </strong>The effects of antenatal corticosteroid (ACS) exposure before 34 weeks on neonates born in the late preterm period are a subject of controversy. We aimed to investigate the impact of ACS exposure before 34 weeks on neonates of dichorionic diamniotic (DCDA) twins born in the late preterm period.</p><p><strong>Methods: </strong>This retrospective cohort study included all DCDA twin gestations born at 34.0-36.6 weeks between January 2014 and December 2020 at a single tertiary medical center. Neonatal outcomes were compared between twin gestations treated with ACS before 34 weeks (ACS group) and those not treated with ACS (control group). A sub-analysis examined neonatal outcomes between those treated with ACS within 14 days of delivery and those treated more than 14 days before delivery.</p><p><strong>Results: </strong>A total of 297 twin gestations were included, with 122 in the ACS group and 175 in the control group. Maternal age, BMI, hypertensive disorders and diabetes mellitus did not differ between the groups. ACS was given for suspected preterm birth (85.2%), fetal growth restriction (4.9%), preeclampsia (3.2%), placental abruption (2.4%), and placenta previa-related bleeding (2.4%). Gestational age (GA) at delivery was lower in the ACS group than in the control group (35.06 ± 0.8 weeks vs. 35.49 ± 0.69 weeks, p < 0.001). The ACS group had higher rates of neonatal admission to the 'neonatal intensive care unit' (NICU)-36.1% vs.16.6%, p < 0.001, and small for gestational age (SGA), 7.2% vs. 9.4%, p = 0.004. By multivariable logistic regression analysis ACS treatment was found to be independently associated with SGA birth (OR 1.997, 95% CI 1.225-3.257, p = 0.006). Within the ACS group, neonates who delivered within 14 days of ACS treatment had higher rates of NICU admission compared to those born > 14 days from ACS treatment (p < 0.004).</p><p><strong>Conclusion: </strong>Twin pregnancies that were born in the late-preterm period and were exposed to ACS before 34 weeks, showed increased rates of SGA and neonatal NICU admission. Caution is needed when administering ACS in twin gestations to avoid unnecessary exposure.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"679"},"PeriodicalIF":2.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninvasive prediction of fetal growth restriction using maternal plasma cell-free RNA: a case-control study.","authors":"Yihong Huang, Ruizhi Wang, Lixia Shen, Lingyi Kong, Peisong Chen, Zilian Wang, Zhuyu Li","doi":"10.1186/s12884-025-07824-5","DOIUrl":"10.1186/s12884-025-07824-5","url":null,"abstract":"<p><strong>Background: </strong>Fetal growth restriction (FGR) is a significant concern due to its potential adverse outcomes for both mothers and infants. Cell-free RNA in maternal plasma has been suggested as a potential biomarker for pregnancy complications, but its effectiveness in predicting FGR remains uncertain. This study aimed to assess the predictive value of cell-free RNA profiling from maternal plasma collected during early to mid-pregnancy for FGR.</p><p><strong>Methods: </strong>This case-control study included pregnant women diagnosed with FGR who had non-invasive prenatal test data. Differentially expressed genes (DEGs) between FGR and controls groups were identified through the analysis of cell-free RNA and placental microarray dataset which downloaded from the Gene Expression Omnibus database. The intersection of DEGs from cell-free RNA and placenta was explored to explore hub genes. The least absolute shrinkage and selection operator regression was used to select the hub genes from the cell-free RNA DEGs. The prediction model was then constructed using logistic regression with hub genes and clinical characteristics. The predictive accuracy of model was evaluated using receiver operating characteristic analysis, calibration curves, and decision curve analysis.</p><p><strong>Results: </strong>A total of 39 FGR samples and 133 control samples were included in this study. Among them, 405 cell-free RNA DEGs were identified. BIN2 was identified as the intersecting gene that was up-regulated in both cell-free RNA and FGR placental transcripts. Subsequently, RHOA and OAZ1 were selected by least absolute shrinkage and selection operator regression. The hub genes, including BIN2, RHOA and OAZ1, exhibited positive correlations with each other and were up-regulated in the FGR group. A logistic regression model incorporating the hub genes and clinical characteristics was constructed, achieving the highest classification performance with area under the curve of 0.812 (95% CI: 0.719-0.904) in the training cohort, 0.863 (95% CI: 0.736-0.989) in the validation cohort, and 0.786 (95% CI: 0.513-1.000) in the time test cohort. The calibration curve indicated good calibration of the model, and the decision curve analysis demonstrated practical value in clinical application.</p><p><strong>Conclusions: </strong>An effective prediction model for FGR was developed by integrating maternal plasma cell-free RNA with clinical characteristics, enabling early evaluation of FGR risk.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"702"},"PeriodicalIF":2.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-care practice and associated factors among postpartum mothers at Karat town, Konso zone, southern, Ethiopia: 2022.","authors":"Gebino Aylate Tengo, Samuel Abdu Aliyu, Enatfenta Sewmehone Endalew, Tilahun Nigusie Adafirie","doi":"10.1186/s12884-025-07821-8","DOIUrl":"10.1186/s12884-025-07821-8","url":null,"abstract":"<p><strong>Background: </strong>Every day, at least 700 women die from complications related to pregnancy, childbirth, and the first 42 days of postpartum period. One of the contributing elements to these issues is a lack of focus on self-care practices during the postpartum period. Thus, understanding the relationship between self-care practices and maternal health is crucial for saving mothers' and babies' lives. Therefore, this study was aimed to assess level of postpartum self-care practice and associated factors among mothers at Karat Town, Konso Zone, Southern, Ethiopia, 2022.</p><p><strong>Methods: </strong>A community-based cross-sectional study was conducted on postpartum mothers who gave birth in the last six weeks in Karat Town from August 1 to September 15, 2022. The systematic random sampling was used to select 419 study participants. Data was collected using a pretest structured questionnaire through a face-to-face interview, entered and cleaned using EPI Info version 4.6, and exported to SPSS version 25 for analysis. Bivariable and multivariable logistic regression was employed to assess the association of the variables, and a P-value less than 0.05 was declared as statistically significant.</p><p><strong>Results: </strong>Out of 419 mothers 140(33.4%) were good postpartum self-care practice. Having an antenatal care visit (AOR = 2.82; 95% CI = 1.394-5.709), institutional delivery (AOR = 2.42; 95% CI = 1.18-4.93), accompanying a husband in antenatal care (AOR = 2.41; 95% CI = 1.37-4.24), counseling by healthcare providers during home visits (AOR = 2.28; 95% CI = 1.24-4.19), and healthcare provider counseling at discharge (AOR = 3.25; 95%CI = 1.72-6.13), and knowledge of participants (AOR = 3.61;95%CI = 2.11-6.19) were factors significantly associated with postpartum self-care.</p><p><strong>Conclusion: </strong>This study showed that self-care practices during postpartum period were low. Inspiring mothers to Attending ANC visits, institutional delivery services, accompanied husbands in antenatal care, strengthening provider's health education at discharge and during home visit, and enhancing knowledge of participants are acceptable manner may improve the postpartum self-care practice.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"700"},"PeriodicalIF":2.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12224642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time to death and its predictors among women with uterine rupture admitted to jimma town public hospitals, South West Ethiopia: retrospective cohort study.","authors":"Lidetu Ababa Kenea, Chaltu Fikru Biyana, Buzuneh Tasfa Marine","doi":"10.1186/s12884-025-07817-4","DOIUrl":"10.1186/s12884-025-07817-4","url":null,"abstract":"<p><strong>Background: </strong>Uterine rupture is a public health issue in resource-limited countries, evidenced to account for 36% of maternal deaths in Ethiopia. This problem has not been studied in the study area, and little is known about the survival of women with uterine rupture. Therefore, this study aimed to assess time to death and its predictors among women with uterine rupture admitted to Jimma Town public Hospitals.</p><p><strong>Method: </strong>An institution-based retrospective cohort study was conducted on all 405 eligible women with uterine rupture admitted to Jimma Town Public Hospitals. Data were collected by using structured questions developed in the Kobo toolbox and analyzed using Stata version 17. The Kaplan-Meier curve was used to estimate the median time to death, and a log-rank test was employed to assess statistically significant survival differences between groups. The Cox-proportional hazards model was fitted to identify predictors of the time to death. A hazard ratio with a 95% significance level and a P-value < 0.05 was considered to declare significant variables.</p><p><strong>Results: </strong>From the total of 405 women followed for 4217 person-days, 38(9.4%) of them have died, leading to an incidence rate of 9 per 1000 women-days. The median survival time was 20 days. Hypovolemic shock (AHR: 3.87 (95%CI: 1.75, 8.53)), severe anemia (AHR: 3.56 (95%CI: 1.39, 9.12)), Not having ANC follow-up (AHR: 2.95 (95%CI: 1.02, 8.59)), admission at night time(AHR: 2.89(95%CI: 1.16, 7.76)), labour duration of ≥ 24 h (AHR: 2.69 (95%CI: 1.26, 5.78)) and having urine bladder rupture (AHR: 2.29(95%CI: 1.08, 4.91)) were predictors of time to death.</p><p><strong>Conclusion: </strong>This study highlights the urgent need for improved healthcare interventions to address the issue of maternal death from uterine rupture and mitigate its impact on national maternal mortality rate. Timely and appropriate medical interventions are crucial in addressing the effects of factors such as hypovolemic shock, severe anemia, lack of ANC follow-up, labour duration of ≥ 24 h, night-time admissions, and urine bladder ruptures on maternal time to death when uterine rupture happens.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"703"},"PeriodicalIF":2.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12224810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internet-based pregnancy information seeking in Lebanon: a cross-sectional study.","authors":"Mazen El Jamal, Ali Al Abed, Mustapha El Haj Hassan, Jana Traboulsi, Kassem Hamze, Samir Mansour, Abbas Hoballah, Rana El Haidari","doi":"10.1186/s12884-025-07810-x","DOIUrl":"10.1186/s12884-025-07810-x","url":null,"abstract":"<p><strong>Introduction: </strong>The internet and social media have become integral parts of people's lives, with many individuals using them to fulfill their information needs. Notably, around 90% of pregnant women worldwide use the internet to seek pregnancy-related information and often make decisions based on what they read. This study aimed to: 1) determine the prevalence of internet and social media use for pregnancy-related information seeking among Lebanese women; 2) assess their knowledge of basic pregnancy information; and 3) explore their attitudes towards information obtained from media sources.</p><p><strong>Methods: </strong>A multi-centric cross-sectional study was conducted from December 1, 2023, to March 15, 2024, across 25 primary health care centers throughout Lebanon. Pregnant women aged between 18 and 45 years completed a questionnaire primarily through face-to-face meetings and additionally online using Google Forms. The questionnaire was distributed in two ways: first, by approaching pregnant women at healthcare centers; and second, by contacting pregnant women via phone. The questionnaire, written in Arabic, included general questions about sociodemographic variables and social media use, as well as specific questions regarding knowledge and information-seeking behavior related to pregnancy.</p><p><strong>Results: </strong>A total of 377 pregnant women participated in the study, 74.3% (280) of whom have previous children. Additionally, 73.5% (277) of the participants used the internet to obtain medical information related to pregnancy, with Google being the most utilized platform. The most commonly searched topics were food and nutritional supplements recommended during pregnancy, drugs and practices to be avoided, and common pregnancy symptoms. Non-mothers were more likely than mothers to follow a medical influencer (p = 0.002) and use the internet for pregnancy-related information (p = 0.01). In a univariate logistic regression analysis, not having had a previous abortion (p = 0.04, OR = 0.61), not experiencing financial difficulties in visiting a doctor (p = 0.02, OR = 0.61), and using the internet for pregnancy-related information (p < 0.0001, OR = 2.55) were predictors of good knowledge about pregnancy information.</p><p><strong>Conclusion: </strong>The internet provides easy access to information for pregnant women. Non-mothers are more likely than mothers to use the internet for medical information. Using the internet helps pregnant women gain knowledge about pregnancy-related information.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"697"},"PeriodicalIF":2.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of postnatal care utilization and maternal practices in rural areas of Lao People's Democratic Republic: a community-based cross-sectional study.","authors":"Souphaphone Sadettan, Souphalak Inthaphatha, Vanpheng Phanthanalay, Douangta Leungmylay, Sengthong Seumlamvanh, Bounfeng Phoummalaysith, Kimihiro Nishino, Eiko Yamamoto","doi":"10.1186/s12884-025-07798-4","DOIUrl":"10.1186/s12884-025-07798-4","url":null,"abstract":"","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"699"},"PeriodicalIF":2.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in the choice of anaesthetic techniques for caesarean sections among Turkish citizens and migrants during the COVID-19 pandemic: an interrupted time series analysis.","authors":"Sevim Baltali, Mehmet Baltali, Ayşegül Ercan, Umut Deniz Akdağ, Mehmet Toptaş","doi":"10.1186/s12884-025-07805-8","DOIUrl":"10.1186/s12884-025-07805-8","url":null,"abstract":"<p><strong>Background: </strong>The aim of the study was to examine the impact of the COVID-19 pandemic on changes in the choice of anaesthetic techniques for singleton caesarean sections among Turkish citizens and migrants before, during the first year of the COVID-19 pandemic, and after vaccination.</p><p><strong>Methods: </strong>This single-center, retrospective observational study was conducted at a tertiary care hospital in Istanbul, Turkey. It included data from 9,744 consecutive women-7,083 (72.7%) Turkish citizens and 2,661 (27.3%) migrants-who underwent singleton caesarean sections between March 2018 and March 2023. The primary outcome was the change in monthly utilization rates of neuraxial anaesthesia (NA) during the COVID-19 pandemic. Secondary objectives included caesarean section urgency and neonatal outcomes.</p><p><strong>Results: </strong>During the study period, there was an increasing trend in the number of caesarean sections performed using NA among Turkish citizens and migrants (relative ratio [RR] 1.003, P < 0.001 and RR 1.005, P < 0.01, respectively). Both groups showed a significant immediate increase in the usage rate of NA at the onset of the COVID-19 pandemic (RR 1.095, P < 0.001 and 1.134, P < 0.001, respectively). The introduction of vaccination had no effect on the use of NA (RR 0.970, P = 1.004, and RR 1.000, P = 0.99, respectively). The significant between-group difference in the pre-pandemic usage rate of NA diminished following the onset of the COVID-19 pandemic, with no significant between-group difference observed after vaccination (93.3% vs. 90.9%., P = 0.006, 98.4% vs. 97.1%, P = 0.0; 95.4% vs. 95.2%, P = 0.801, respectively). Category-1 caesarean section events increased throughout the study period (471(10.7%) before COVID-19, 321(17.0%) during the first year, and 700 (20.2%) after vaccination; P < 0.001). There were no significant differences in the incidence of composite adverse neonatal outcomes (stillbirths, Apgar 5-min score < 7) among the three time periods (89(2.0%), 41(2.2%), and 49(1.4%); P = 0.065).</p><p><strong>Conclusion: </strong>During the COVID-19 pandemic, our study revealed a continuation of the upward trend in the use of NA for caesarean sections.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"694"},"PeriodicalIF":2.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing and validating a risk prediction model for caesarean delivery in Northwest Amhara comprehensive specialized hospitals.","authors":"Mulat Ayele, Eyob Shitie Lake, Befkad Derese Tilahun, Gizachew Yilak, Abebaw Alamrew, Getinet Kumie, Tegene Atamenta Kitaw, Biruk Beletew Abate, Getnet Gedefaw Azeze, Nigus Bililign Yimer","doi":"10.1186/s12884-025-07822-7","DOIUrl":"10.1186/s12884-025-07822-7","url":null,"abstract":"","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"701"},"PeriodicalIF":2.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12224388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological conduct and risk of bias in studies on prenatal birthweight prediction models using machine learning techniques: a systematic review.","authors":"Jing Gao, Yujun Yao, Jingdong Xue, Ruiyao Chen, XingYu Yang, Jie Xu, Weiwei Cheng","doi":"10.1186/s12884-025-07727-5","DOIUrl":"10.1186/s12884-025-07727-5","url":null,"abstract":"<p><strong>Objective: </strong>To assess the methodological quality and the risk of bias, of studies that developed prediction models using Machine Learning (ML) techniques to estimate prenatal birthweight.</p><p><strong>Study design and methods: </strong>We conducted a systematic review, searching the PubMed databases between 01/01/2018 and 01/08/2022, for studies that developed fetal weight prediction models using ML. We used the Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD) statement to assess the reporting quality of included publications and the Prediction Model Risk of Bias Assessment Tool (PROBAST) to assess the risk of bias. We measured the overall adherence to the TRIPOD reporting checklist, provided a detailed analysis of the methodological quality of each study, and examined risk of bias in specific domains, including participant, predictor, outcome and analysis.</p><p><strong>Results: </strong>Fourteen studies were included and the adherence to the TRIPOD reporting items ranged from 34.62% to 80.77%, with a median adherence of 63.19%. The studies showed significant variation in their methodological rigor, with a particularly high risk of bias in the selection of participants and predictors. Notably, issues related to missing data, sample size adequacy, performance evaluation, and model validation were prominent across studies. Several studies showed limited model transparency and reproducibility.</p><p><strong>Conclusion: </strong>Methodological quality of the ML-based prediction models for prenatal birthweight estimation was generally poor, with most studies at high risk of bias. There is an urgent need for improvements in the design and reporting of these studies. The adaptation of the TRIPOD and PROBAST statements specifically for ML models should be promoted to enhance transparency and reproducibility, which would facilitate the wider clinical application of ML-based prediction models and reduce research waste.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"696"},"PeriodicalIF":2.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A surveillance-based epidemiological study of renal agenesis in 25 million births in china, 2007-2020.","authors":"Yuyang Gao, Wenli Xu, Wenyan Li, Zhiyu Chen, Qi Li, Zhen Liu, Li Dai","doi":"10.1186/s12884-025-07807-6","DOIUrl":"10.1186/s12884-025-07807-6","url":null,"abstract":"<p><strong>Background: </strong>Renal agenesis (RA), a rare congenital kidney defect, varies in clinical severity. Unilateral renal agenesis (URA) is more prevalent and may cause long-term renal complications, whereas bilateral renal agenesis (BRA) is typically fatal. While epidemiological data on RA is limited in China, understanding its prevalence and associated factors is crucial for public health interventions.</p><p><strong>Methods: </strong>We conducted a prevalence analysis using data from the Chinese Birth Defects Monitoring Network between 2007 and 2020. Prevalence rates of RA, URA, and BRA were calculated and stratified by birth year, maternal age, residence area, geographical region, and infant sex. Temporal trends in prevalence were examined. We also investigated pregnancy outcomes among affected infants, including preterm births, low birth weight, early neonatal deaths, and termination of pregnancy for fetal anomaly (TOPFA). Furthermore, co-occurring congenital anomalies were assessed. Poisson regression analysis was used to assess the distribution of URA and BRA across residential areas and geographic regions and to identify factors associated with their prevalence.</p><p><strong>Results: </strong>Among 25,909,000 births between 2007 and 2020, a total of 5,906 cases of RA were identified (5,020 URA and 780 BRA). The prevalence rates per 10,000 live and still births were 2.28 for RA, 1.94 for URA, and 0.30 for BRA, all showing an increasing trend over the study period. Compared to URA, BRA was significantly associated with a higher proportion of preterm birth, low birth weight, early neonatal death, and TOPFA. Poisson regression analysis revealed a consistent distribution of URA and BRA across residential areas and geographic regions, with higher prevalence observed in urban areas and the eastern and central regions of China. Maternal age < 35 years and female sex were associated with a higher prevalence of URA, while male sex was associated with a higher prevalence of BRA. Both URA and BRA frequently co-occurred with congenital malformations of the circulatory, urinary, and musculoskeletal systems.</p><p><strong>Conclusions: </strong>The study provides the first comprehensive epidemiological assessment of RA in China. The increasing prevalence and distinct differences in the pregnancy outcomes between URA and BRA underscore the importance of timely prenatal diagnosis and appropriate counseling for affected families.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"689"},"PeriodicalIF":2.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}