BMC Pregnancy and Childbirth最新文献

筛选
英文 中文
Epidural labor analgesia is a potential risk factor for increased blood loss within two hours after delivery in women with gestational hypertension: a retrospective cohort study. 硬膜外分娩镇痛是妊娠期高血压妇女分娩后2小时内失血增加的潜在危险因素:一项回顾性队列研究。
IF 2.8 2区 医学
BMC Pregnancy and Childbirth Pub Date : 2025-05-06 DOI: 10.1186/s12884-025-07648-3
Weiguo Sun, Liping Zhou, Zhijiang Liang, Jie Jia
{"title":"Epidural labor analgesia is a potential risk factor for increased blood loss within two hours after delivery in women with gestational hypertension: a retrospective cohort study.","authors":"Weiguo Sun, Liping Zhou, Zhijiang Liang, Jie Jia","doi":"10.1186/s12884-025-07648-3","DOIUrl":"https://doi.org/10.1186/s12884-025-07648-3","url":null,"abstract":"<p><strong>Background: </strong>Postpartum hemorrhage remains the leading cause of maternal mortality during childbirth worldwide. Given that pregnant women with gestational hypertension are particularly vulnerable to blood volume reduction, there is currently insufficient evidence to determine whether epidural labor analgesia impacts these patients within the first 2 h postpartum.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted involving 1,903 term parturients with hypertensive disorders of pregnancy admitted to Guangdong Women and Children Hospital between January 2012 and December 2021. Participants were categorized into two groups based on receipt of epidural labor analgesia: the analgesia group (n = 884) and non-analgesia group (n = 1,019). Primary outcomes included early postpartum hemorrhage (PPH) defined as ≥ 300 mL blood loss within 2 h post-delivery and associated risk factors. Statistical analyses were performed using chi-square tests for categorical variables, Mann-Whitney U tests for continuous variables, and multivariate logistic regression to evaluate independent associations between epidural analgesia and PPH.</p><p><strong>Results: </strong>Results showed significantly higher 2-h postpartum blood loss ≥ 300 mL in epidural analgesia vs non-analgesia groups among gestational hypertension patients (54.0% vs 46.0%, P = 0.003). Multivariate analysis identified epidural analgesia as an independent risk factor for postpartum hemorrhage (adjusted OR = 1.304, 95% CI:1.013-1.680, P = 0.039). Obstetric complications including placental adhesion (OR = 2.405) and macrosomia (OR = 2.644) also correlated with hemorrhage risk (all P < 0.05). Birth canal injury demonstrated a protective association (adjusted OR = 0.63, 0.49-0.81, P < 0.001).</p><p><strong>Conclusion: </strong>Epidural labor analgesia may elevate the risk of early postpartum hemorrhage (≤ 2 h) in parturients with gestational hypertension. Clinical practice should prioritize intensive postpartum surveillance and individualized analgesic protocols to balance analgesic efficacy and hemorrhagic risk.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"538"},"PeriodicalIF":2.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Your baby has down syndrome: a reflexive thematic analysis of breaking the news to parents. 你的宝宝患有唐氏综合症:向父母透露消息的反身性主题分析。
IF 2.8 2区 医学
BMC Pregnancy and Childbirth Pub Date : 2025-05-06 DOI: 10.1186/s12884-025-07665-2
Marcela Tenorio D, Johanna Sagner-Tapia, Renata Garibaldi, Vaso Totsika
{"title":"Your baby has down syndrome: a reflexive thematic analysis of breaking the news to parents.","authors":"Marcela Tenorio D, Johanna Sagner-Tapia, Renata Garibaldi, Vaso Totsika","doi":"10.1186/s12884-025-07665-2","DOIUrl":"https://doi.org/10.1186/s12884-025-07665-2","url":null,"abstract":"<p><p>The communication of a Down syndrome diagnosis to mothers is a pivotal moment that can impact their emotional well-being and the subsequent care for their child. This study aimed to explore maternal experiences with receiving a Down syndrome diagnosis. A total of 40 mothers participated, 42.5% received a prenatal diagnosis, 17.5% received the diagnosis during labor and delivery, and 40% received the information at the early postnatal period. Through reflexive thematic analysis, four key themes emerged: (1) About Who and How the News Was Delivered (2), About When the News Was Delivered (3), On Where the News Should Be Delivered (4), parents' positive experiences emerging from this, predominantly, negative episode. Our findings emphasize the need for improved training for healthcare professionals in delivering sensitive diagnoses, with an emphasis on empathy, accurate information, and support resources for families.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"536"},"PeriodicalIF":2.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A plethora of laboratory protocols for vitamin D receptor (VDR) gene variants detection: a systematic review of associations with hypertensive disorders of pregnancy. 维生素D受体(VDR)基因变异检测的大量实验室方案:与妊娠高血压疾病相关的系统综述。
IF 2.8 2区 医学
BMC Pregnancy and Childbirth Pub Date : 2025-05-06 DOI: 10.1186/s12884-025-07510-6
Yakubu Ibrahim, Nurul Iftida Basri, Amilia Afzan Mohd Jamil, Norshariza Nordin
{"title":"A plethora of laboratory protocols for vitamin D receptor (VDR) gene variants detection: a systematic review of associations with hypertensive disorders of pregnancy.","authors":"Yakubu Ibrahim, Nurul Iftida Basri, Amilia Afzan Mohd Jamil, Norshariza Nordin","doi":"10.1186/s12884-025-07510-6","DOIUrl":"https://doi.org/10.1186/s12884-025-07510-6","url":null,"abstract":"<p><strong>Introduction: </strong>Genetic variations in the vitamin D receptor (VDR) gene have been inconsistently linked to hypertensive disorder of pregnancy (HDP) across different populations. This systematic review aims to evaluate the laboratory protocols of VDR detection and association with HDP.</p><p><strong>Methods: </strong>We performed a systematic review using the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guideline and conducted an article search using the Web of Science, PubMed, Scopus, EBSCOhost (MEDLINE and CINAHL) databases. We included all studies involving one or more of the major VDR gene variants (FokI, BsmI, ApaI, and TaqI) and association with HDP.</p><p><strong>Results: </strong>Of the 9 studies evaluated, 6 (67%) studies were reported from Asia, 2 (22%) from Europe, and 1 (11%) from Latin America. Our analysis of VDR variant detection protocols revealed that approximately 6 (67%) studies used polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP), of which 3 (33%) reported a significant association with FokI variant. Two (22%) of studies used TaqMan PCR and found an association with FokI variant. Only 1 (11%) study utilised allele-specific PCR (AS-PCR) for ApaI variant genotyping. For association analysis of the variants with HDP in populations, 4 studies (44%) reported an association with FokI variant in Asians. Two studies (22%) reported BsmI variant in Caucasians. TaqI variant was not associated with HDP in all the populations studied.</p><p><strong>Conclusions: </strong>Our findings suggest an association between VDR genetic variation and HDP across different populations. To enhance consistency in these associations, future studies should use reliable detection methods and strict adherence to quality control measures. This could help in the identification of population-specific biomarkers, prevalent variants, and support personalized management strategies to reduce maternal morbidity and mortality related to HDP.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"539"},"PeriodicalIF":2.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of unintended pregnancy on maternal bonding impairment among Japanese mothers: a longitudinal study from pregnancy to one month postpartum. 日本母亲意外怀孕对母亲关系障碍的影响:一项从怀孕到产后一个月的纵向研究。
IF 2.8 2区 医学
BMC Pregnancy and Childbirth Pub Date : 2025-05-06 DOI: 10.1186/s12884-025-07642-9
Hitoshi Kaneko, Yuya Makino, Mami Nakano, Yuichiro Takahashi, Masako Matsui, Kazuyo Ogawa
{"title":"The effects of unintended pregnancy on maternal bonding impairment among Japanese mothers: a longitudinal study from pregnancy to one month postpartum.","authors":"Hitoshi Kaneko, Yuya Makino, Mami Nakano, Yuichiro Takahashi, Masako Matsui, Kazuyo Ogawa","doi":"10.1186/s12884-025-07642-9","DOIUrl":"10.1186/s12884-025-07642-9","url":null,"abstract":"<p><strong>Background: </strong>Numerous studies have been conducted regarding maternal bonding; however, there is a lack of studies investigating the association with unintended pregnancy. This study aimed to examine the effects of unintended pregnancy on maternal bonding using a longitudinal design from pregnancy to one month postpartum.</p><p><strong>Methods: </strong>Participants were 78 mothers who attended the Department of Obstetrics for prenatal care at 20.5 weeks of gestational age. They responded to the Postpartum Bonding Questionnaire (PBQ) and the Edinburgh Postnatal Depression Scale (EPDS). Furthermore, we asked whether the pregnancy was unintended. At one month postpartum, they responded to the questionnaires again. We performed two-way repeated-measures analysis of variance to assess the effect of group (unintended pregnancy or intended pregnancy) and time (during pregnancy or one month postpartum) on the PBQ and EPDS scores.</p><p><strong>Results: </strong>Mothers who had unintended pregnancies had significantly impaired maternal bonding compared to expected pregnancy mothers, both during pregnancy and one month postpartum. In addition, both unintended and expected pregnancy mothers had significantly decreased impaired maternal bonding at one month postpartum. Regarding depression, mothers with unintended pregnancy had significantly higher EPDS scores than mothers with expected pregnancy, both during pregnancy and one month postpartum.</p><p><strong>Conclusions: </strong>Our findings emphasize that healthcare providers should promptly identify mothers with unintended pregnancies and conduct thorough assessments of mother-infant interactions postpartum.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"540"},"PeriodicalIF":2.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of simultaneous IgM, IgG avidity, and IgA testing in diagnosis of acute toxoplasmosis in pregnant women: a systematic review and meta-analysis study. 评估同时IgM、IgG贪婪度和IgA检测在孕妇急性弓形虫病诊断中的作用:一项系统回顾和荟萃分析研究。
IF 2.8 2区 医学
BMC Pregnancy and Childbirth Pub Date : 2025-05-06 DOI: 10.1186/s12884-025-07580-6
Mostafa Tork, Mitra Sadeghi, Hossein Asgarian-Omran, Bahareh Basirpour, Somayeh Ahmadi, Fatemeh Ghasemzadeh, Shahabeddin Sarvi, Shirzad Gholami, Seyed Abdollah Hosseini, Ahmad Daryani, Sargis A Aghayan
{"title":"Assessment of simultaneous IgM, IgG avidity, and IgA testing in diagnosis of acute toxoplasmosis in pregnant women: a systematic review and meta-analysis study.","authors":"Mostafa Tork, Mitra Sadeghi, Hossein Asgarian-Omran, Bahareh Basirpour, Somayeh Ahmadi, Fatemeh Ghasemzadeh, Shahabeddin Sarvi, Shirzad Gholami, Seyed Abdollah Hosseini, Ahmad Daryani, Sargis A Aghayan","doi":"10.1186/s12884-025-07580-6","DOIUrl":"10.1186/s12884-025-07580-6","url":null,"abstract":"<p><strong>Backgrounds: </strong>Toxoplasma gondii is a relatively common parasite with a global prevalence that can cause toxoplasmosis. This infection usually does not have clear symptoms, so timely and accurate detection plays a major role in the treatment of this disease. This study reviewed Toxoplasma antibodies dependent serologic tests in pregnancy, assessing their diagnostic effectiveness to guide healthcare providers, particularly obstetricians and gynecologists.</p><p><strong>Methods: </strong>In this systematic review and meta-analysis, we utilized four different databases for our search and adhered to the PRISMA guidelines to collect pertinent studies in duration of 2000 to April 2024. After carefully evaluating the inclusion/exclusion criteria list, we ultimately selected 67 qualifying studies for our analysis and subjecting the obtained data to statistical scrutiny.</p><p><strong>Results: </strong>Data analysis revealed that the pooled seroprevalence of IgM anti-T. gondii among pregnant women tested were 2.1% (95% CI = 1.67 to 3.03). Moreover, the weighted seroprevalence rate estimate of low IgG avidity in IgM-positive pregnant women was 30% (95% CI = 28 to 31) and the seroprevalence of IgA in IgM-positive pregnant women was 43% (95% CI = 18 to 70). Combining the IgG avidity test results with those of IgM and IgA can significantly improve the accuracy of diagnosing recent and past Toxoplasma infections.</p><p><strong>Conclusions: </strong>This approach is particularly valuable for pregnant women, as it improves the reliability of serological test outcomes and helps to provide timely treatment and mitigate irreversible complications associated with toxoplasmosis.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"537"},"PeriodicalIF":2.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differences in lymphocyte subsets of spiral artery associated with impaired vascular remodeling in hypertensive disorders of pregnancy. 妊娠高血压疾病中螺旋动脉淋巴细胞亚群与血管重构受损相关的差异。
IF 2.8 2区 医学
BMC Pregnancy and Childbirth Pub Date : 2025-05-06 DOI: 10.1186/s12884-025-07653-6
Ayako Tateishi, Tsutomu Miyamoto, Maki Ohya, Tanri Shiozawa, Hiroyuki Kanno
{"title":"Differences in lymphocyte subsets of spiral artery associated with impaired vascular remodeling in hypertensive disorders of pregnancy.","authors":"Ayako Tateishi, Tsutomu Miyamoto, Maki Ohya, Tanri Shiozawa, Hiroyuki Kanno","doi":"10.1186/s12884-025-07653-6","DOIUrl":"https://doi.org/10.1186/s12884-025-07653-6","url":null,"abstract":"<p><p>Hypertensive disorders of pregnancy (HDP) is assumed to be triggered by incomplete remodeling of the decidual spiral arteries. We examined the lymphocyte subsets and identified immune differences in the spiral arteries between HDP and normal pregnancies, and between remodeled and non-remodeled arteries such as the muscular artery and acute atherosis. One hundred seventy-three patients with HDP diagnosed at our hospital between 2008 and 2017 were included. Patients with a normal course of delivery and patients with premature birth after 34 weeks without pathological changes and abnormalities in the pregnancy course were included in the control group. The infiltrating lymphocytes were evaluated using immunohistochemistry. Acute atherosis was observed in 56 patients (32.4%) of all HDP patients. In patients that presented HDP with acute atherosis, the density of CD8<sup>+</sup> T cells and CD4<sup>+</sup> T cells was higher in the acute atherosis than those in the non-remodeled muscular artery. CD4<sup>+</sup> T cells were more abundant in the non-remodeled muscular artery compared to the remodeled artery. In control patients, the density of CD4<sup>+</sup> T cells was higher in the non-remodeled muscular artery than that in the remodeled artery; there was no difference in the density of CD56<sup>+</sup> natural killer cells. There was no difference in the density of CD3<sup>+</sup> T cells and CD56<sup>+</sup> natural killer cells in the remodeled artery between patients presenting HDP with acute atherosis and control patients. These immune differences may cause changes in local cytokine balance around the spiral artery, contributing to the development of HDP.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"535"},"PeriodicalIF":2.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleeping for two: a cross-sectional study on associations between objectively measured sleep during early to mid-pregnancy and maternal and fetal outcomes and inflammatory biomarker profiles. 两个人的睡眠:一项关于怀孕早期到中期客观测量的睡眠与母婴结局和炎症生物标志物之间关系的横断面研究。
IF 2.8 2区 医学
BMC Pregnancy and Childbirth Pub Date : 2025-05-05 DOI: 10.1186/s12884-025-07634-9
Caitlin Macdonald, Tryfonas Pitsillos, Anna-Karin Wikström, Alkistis Skalkidou, Peter Meerlo, Jocelien Olivier, Jelmer Prins, Inger Sundström Poromaa, Theodora Kunovac Kallak
{"title":"Sleeping for two: a cross-sectional study on associations between objectively measured sleep during early to mid-pregnancy and maternal and fetal outcomes and inflammatory biomarker profiles.","authors":"Caitlin Macdonald, Tryfonas Pitsillos, Anna-Karin Wikström, Alkistis Skalkidou, Peter Meerlo, Jocelien Olivier, Jelmer Prins, Inger Sundström Poromaa, Theodora Kunovac Kallak","doi":"10.1186/s12884-025-07634-9","DOIUrl":"https://doi.org/10.1186/s12884-025-07634-9","url":null,"abstract":"<p><strong>Background: </strong>Pregnant women often experience subjective sleep disturbances shown to be associated with maternal and fetal outcomes. However, subjectively experienced sleep often deviates from objective measurements. Therefore, the aim of this study was to explore the relationship between objectively measured sleep in early to mid-pregnancy and maternal and fetal outcomes and inflammatory biomarkers.</p><p><strong>Methodology: </strong>A total of 1,610 pregnant women aged 18 or older from the Safe Physical Activity in Pregnancy (SPAP) study were recruited during early (week 10-14) to mid-pregnancy (week 16-19). Blood samples were taken and sleep was monitored using an Actiwatch, tracking total sleep time, sleep efficiency, wake after sleep onset, and sleep onset latency for 7 days in early to mid-pregnancy. A combined sleep categorisation was created using total sleep time and sleep efficiency to categorise participants into three sleep quality groups: Good, Intermediate, and Poor. Maternal and fetal outcomes were collected via questionnaires, medical records, and plasma samples were analysed using the Olink cardiovascular paneI Il (n = 407).</p><p><strong>Results: </strong>A total of 1,444 participants were included. The women were categorized as good sleepers (50.4%), intermediate (32.6%), or poor sleepers (17.0%) based on the distribution of the participant's sleep parameters. Poor sleep was more common in women born outside Europe, those with higher pre-gestational BMI, and those with pre-pregnancy diabetes. Sleep groups did not differ in metabolic factors. Poor sleep was associated with an increased likelihood of requiring an emergency caesarean section (AOR = 1.86, 95% CI 1.13-3.05). No significant associations were found for other outcomes such as pre-eclampsia, premature birth, small for gestational age etc. Nine inflammatory biomarkers were significantly lower in poor sleepers, while one marker was higher.</p><p><strong>Conclusion: </strong>Poor sleep in early to mid-pregnancy was more common in pregnant women with pre-pregnancy diabetes, obesity, and those born outside of Europe. Poor sleep was associated with a higher likelihood of emergency caesarean section, but no other maternal or fetal outcomes. An overall trend was observed towards lower levels of inflammatory markers in women that slept poorly; however, additional studies are needed to better understand the immune system's role in the relationship between sleep, maternal health, and maternal and fetal outcomes. Possible mechanisms underlying these associations warrant further research.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"533"},"PeriodicalIF":2.8,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The value of subcutaneous tissue closure and drain in obese women undergo elective caesarean section: a randomized controlled trial. 皮下组织关闭和引流在肥胖妇女择期剖宫产中的价值:一项随机对照试验。
IF 2.8 2区 医学
BMC Pregnancy and Childbirth Pub Date : 2025-05-05 DOI: 10.1186/s12884-025-07579-z
Mohamed A Shalaby, Hanan H M Metwally, Ahmed M Maged, Yomna A Bayoumi, Noha Salah
{"title":"The value of subcutaneous tissue closure and drain in obese women undergo elective caesarean section: a randomized controlled trial.","authors":"Mohamed A Shalaby, Hanan H M Metwally, Ahmed M Maged, Yomna A Bayoumi, Noha Salah","doi":"10.1186/s12884-025-07579-z","DOIUrl":"https://doi.org/10.1186/s12884-025-07579-z","url":null,"abstract":"<p><strong>Objective: </strong>to compare the efficacy and safety of subcutaneous suture reapproximation alone versus suture plus subcutaneous drain or non-closure for the prevention of wound complications in obese women undergoing elective cesarean delivery (CD).</p><p><strong>Methods: </strong>This randomized controlled open label trial was conducted on 352 obese women candidates for elective CD. Participants were randomized into 4 groups: group I (n = 89) were allocated for interrupted closure of subcutaneous tissue with insertion of subrectus drain, group II (n = 88) were allocated for interrupted closure of subcutaneous tissue, group III (n = 88) were allocated for insertion of subrectus drain, group IV (n = 87) were allocated for non-closure of subcutaneous tissue without insertion of subrectus drain The primary outcome parameter was the development of wound complications including seroma, infection and dehiscence. Secondary outcome included postoperative pain assessed by VAS, postoperative fever, time of hospital stay and duration of surgery.</p><p><strong>Results: </strong>There were significant differences between the 4 groups regarding the mean duration of surgery (48.67 ± 2.84, 46.56 ± 4.80, 45.95 ± 4.29, and 41.59 ± 5.08 in combined, sutures only, drain only and none groups, respectively, P < 0.001). Assessment of outcome parameters revealed significant differences between the 4 groups regarding postoperative pain (2.93 ± 1.95, 3.62 ± 2.26, 3.83 ± 2.16, and 3.99 ± 2.032, P = 0.006), postoperative fever (3/68 (3.5%),5/86 (5.8%),3/68 (3.5%),, and 12/86 (14%), P = 0.017) wound infection (4/68 (4.7%),7/86 (8.1%),4/68 (4.7%),, and 13/86 (15.1%), P = 0.035) and wound dehiscence (4/68 (4.7%),6/86 (7%),8/68 (9.3%),, and 16/86 (18.6%), P = 0.011) and highly statistical significant differences regarding wound seroma (4/68 (4.7%),13/86 (15.1%),6/68 (7%),, and 21/86 (24.4%), P < 0.001) and redressing(10/68 (11.6%),17/86 (19.8%),19/68 (22.1%), and 32/86 (37.2%), P < 0.001) 08 in combined, sutures only, drain only and none groups, respectively.</p><p><strong>Conclusion: </strong>The additional use of a subcutaneous drain along with a standard subcutaneous suture reapproximation technique is effective for the prevention of wound complications named seroma, redressing, dehiscence and infection in obese women undergoing CD.</p><p><strong>Trial registration: </strong>NCT04177381 Date of registration: 21/11/2019.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"534"},"PeriodicalIF":2.8,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early prediction of preeclampsia from clinical, multi-omics and laboratory data using random forest model. 使用随机森林模型从临床、多组学和实验室数据中早期预测子痫前期。
IF 2.8 2区 医学
BMC Pregnancy and Childbirth Pub Date : 2025-05-05 DOI: 10.1186/s12884-025-07582-4
Qiang Zhao, Jia Li, Zhuo Diao, Xiao Zhang, Suihua Feng, Guixue Hou, Wenqiu Xu, Zhiguang Zhao, Zhixu Qiu, Wenzhi Yang, Si Zhou, Peirun Tian, Qun Zhang, Weiping Chen, Huahua Li, Gefei Xiao, Jie Qin, Liqing Hu, Zhongzhe Li, Liang Lin, Shunyao Wang, Ruyun Gao, Wuyan Huang, Xiaohong Ruan, Sufen Zhang, Jianguo Zhang, Lijian Zhao, Rui Zhang
{"title":"Early prediction of preeclampsia from clinical, multi-omics and laboratory data using random forest model.","authors":"Qiang Zhao, Jia Li, Zhuo Diao, Xiao Zhang, Suihua Feng, Guixue Hou, Wenqiu Xu, Zhiguang Zhao, Zhixu Qiu, Wenzhi Yang, Si Zhou, Peirun Tian, Qun Zhang, Weiping Chen, Huahua Li, Gefei Xiao, Jie Qin, Liqing Hu, Zhongzhe Li, Liang Lin, Shunyao Wang, Ruyun Gao, Wuyan Huang, Xiaohong Ruan, Sufen Zhang, Jianguo Zhang, Lijian Zhao, Rui Zhang","doi":"10.1186/s12884-025-07582-4","DOIUrl":"https://doi.org/10.1186/s12884-025-07582-4","url":null,"abstract":"<p><strong>Background: </strong>Predicting preeclampsia (PE) within the first 16 weeks of gestation is difficult due to various risk factors, poorly understood causes and likely multiple pathogenic phenotypes of preeclampsia.  OBJECTIVES: In this study, we aimed to develop prediction models for early-onset preeclampsia (EPE) and late-onset preeclampsia (LPE) respectively using clinical data, metabolome and proteome analyses on plasma samples and laboratory data.</p><p><strong>Methods: </strong>We retrospectively recruited 56 EPE, 50 LPE patients and 92 normotensive controls from three tertiary hospitals and used clinical and laboratory data in early pregnancy. Models for EPE and LPE were fitted with the use of patient' clinical, multi-omics and laboratory data.</p><p><strong>Results: </strong>By comparing multi-omics and laboratory test variables between EPE, LPE and healthy controls, we identified sets of differentially expressed biomarkers, including 49 and 33 metabolites, 28 and 36 proteins as well as 5 and 7 laboratory variables associated with EPE and LPE respectively. Using the random forest algorithm, we developed a prediction model using seven clinical factors, seven metabolites, five laboratory test variables. The model yielded the highest accuracy for EPE prediction with good sensitivity (87.5%, 95% confidence interval [CI]: 67.64%-97.34%) and specificity (94.1%, 95% CI: 80.32%-99.28%). We also developed a prediction model that exhibited high accuracy in separating LPE from controls (sensitivity: 66.67%, 95% CI: 43.03%-85.41%; specificity: 94.12%, 95% CI: 80.32%-99.28%) using seven clinical factors, five metabolites and eight proteins.</p><p><strong>Conclusion: </strong>Our study has identified a set of significant omics and laboratory features for PE prediction. The established models yielded high prediction performance for preeclampsia risk from clinical, multi-omics and laboratory information.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"531"},"PeriodicalIF":2.8,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of respectful maternity care on the perception of traumatic birth among mothers in southern Türkiye. 尊重产妇护理对<s:1>基耶省南部母亲创伤性分娩知觉的影响。
IF 2.8 2区 医学
BMC Pregnancy and Childbirth Pub Date : 2025-05-05 DOI: 10.1186/s12884-025-07553-9
Özlem Koç, Süleyman Cemil Oğlak
{"title":"The effect of respectful maternity care on the perception of traumatic birth among mothers in southern Türkiye.","authors":"Özlem Koç, Süleyman Cemil Oğlak","doi":"10.1186/s12884-025-07553-9","DOIUrl":"https://doi.org/10.1186/s12884-025-07553-9","url":null,"abstract":"<p><strong>Background: </strong>Respectful maternity care is a universal right for all reproductive women. The relationship between women and maternity care providers is crucial throughout pregnancy, birth, and postpartum. Qualitative studies suggest that care quality and interactions with healthcare professionals impact women more than medical interventions. This study examines the effect of respectful maternity care on the perception of traumatic birth.</p><p><strong>Methods: </strong>The study was conducted with 540 mothers who had a healthy birth in a public hospital in southern Türkiye between May and August 2024. The data collection process was carried out in two stages. In the first stage, mothers who completed the 24-h postpartum period filled out the Personal Information Form and the Women's Perception of Respectful Maternity Care Scale, and their contact information was obtained. In the second stage, one week after birth, the Birth-Related Trauma Perception Scale was completed through phone interviews with the mothers.</p><p><strong>Results: </strong>Mothers'perceptions of birth-related trauma and respectful maternal care were found to have significant relationships with many sociodemographic and obstetric variables (p < 0.05). The participants'mean respectful maternal care score and mean trauma perception score were 68.55 ± 9.30 and 120.80 ± 14.53, respectively. In addition, a high level of negative correlation was found between birth trauma and respectful maternal care (r = - 0.864; p < 0.001).</p><p><strong>Conclusions: </strong>The study revealed that women exhibited a high perception of psychological trauma and a moderate perception of respectful maternity care. The findings indicate that sociodemographic and obstetric factors play a significant role in shaping women's experiences of both respectful care and birth trauma. Notably, a strong negative correlation was identified between respectful maternity care and the perception of birth trauma.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"532"},"PeriodicalIF":2.8,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信