BMC Pregnancy and Childbirth最新文献

{"title":"Acceptability and factors associated with minimum postpartum stay in public health facilities among mothers in Mekelle: a mixed-methods study.","authors":"Gebretsadik Kiros Lema, Haftamu Ebuy, Ytbarek Tadesse, Mache Tsadik","doi":"10.1186/s12884-025-08242-3","DOIUrl":"10.1186/s12884-025-08242-3","url":null,"abstract":"","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"1053"},"PeriodicalIF":2.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined vaginal progesterone and cervical Pessary effect on preterm birth in Singleton pregnancies with short cervix: a retrospective cohort study.","authors":"Nooshin Eshraghi, Fatemeh Jayervand, Neda Hashemi, Tahmineh Ezazi Bojnordi, Mahtab Motevasselian, Amene Ranjbar, Elahe Ghaderi","doi":"10.1186/s12884-025-08255-y","DOIUrl":"10.1186/s12884-025-08255-y","url":null,"abstract":"<p><strong>Background: </strong>To determine whether the combination of vaginal progesterone and cervical pessary initiated during the second trimester reduces the incidence of preterm birth and enhance neonatal outcomes among women diagnosed with singleton pregnancies and a short cervix.</p><p><strong>Study design: </strong>We conducted a retrospective cohort study involving 322 pregnant individuals with singleton gestations and a sonographically confirmed short cervix (≤ 25 mm), managed at Akbarabadi Hospital, a tertiary referral center. Participants were allocated into two treatment groups: one received both vaginal progesterone (200 mg daily) and an Arabin cervical pessary, and the other received progesterone alone. Primary outcomes included the incidence of spontaneous preterm birth before 34 and 37 weeks of gestation. Secondary outcomes encompassed neonatal morbidity, NICU admission, birth weight, and maternal complications. Comparative analyses were conducted using Cox proportional hazards regression and standard statistical tests, with adjustments for potential confounders.</p><p><strong>Results: </strong>Preterm birth before 34 weeks was significantly lower in the combination group (3.1%) compared to the progesterone-only group (12.4%; p = 0.002). Similarly, births before 37 weeks were reduced (22.4% vs. 37.3%; p = 0.003). The combination group showed better neonatal outcomes, including fewer NICU admissions (34.8% vs. 54.0%; p = 0.012), shorter NICU stays were more frequent in the combination group (66% discharged within 3 days vs. 34% in progesterone-only group; p = 0.012), and a lower need for resuscitation (5.6% vs. 12.4%; p = 0.032). Maternal complications (including postpartum hemorrhage, infection, and ICU admissions) were noticeably lower in the combination group (2.5% vs. 10.6%; p = 0.003).</p><p><strong>Conclusion: </strong>Combining vaginal progesterone with a cervical pessary during mid-pregnancy can significantly reduce the risk of preterm birth and improve outcomes for both mother and baby in singleton pregnancies with a short cervix. These findings support incorporating dual therapy into clinical practice guidelines as an effective approach to preventing preterm birth in high-risk populations. These findings suggest that dual therapy may reduce preterm birth risk, but confirmation in prospective randomized trials is warranted.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"1055"},"PeriodicalIF":2.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12509338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstetric outcomes following artificial and natural cycle frozen embryo transfer in patients with and without endometriosis: a national cohort study.","authors":"Eun Hee Yu, Hyun Joo Lee, Sul Lee, Hyung Joon Yoon, Seung Chul Kim, Jong Kil Joo, Yong Jin Na","doi":"10.1186/s12884-025-08314-4","DOIUrl":"10.1186/s12884-025-08314-4","url":null,"abstract":"<p><strong>Background: </strong>Endometriosis is a common cause of infertility in women of reproductive age, and many affected women require assisted reproductive technology (ART) to conceive. It is also associated with increased risks of adverse obstetric complications. However, the impact of different frozen embryo transfer (FET) protocols on outcomes in this population remains unclear. This study aimed to evaluate obstetric outcomes after FET, comparing endometrial preparation methods in women with and without endometriosis using a nationwide cohort from the Republic of Korea.</p><p><strong>Methods: </strong>We analyzed data from the National Health Insurance Service database (October 2017 to December 2021), including 44,118 singleton pregnancies following in vitro fertilization. The the artificial cycle (AC)-FET and the natural cycle (NC)-FET groups were distinguished based on prescription records, and patients were further categorized into endometriosis and non-endometriosis groups using the ICD-10 code N80. Logistic regression models were used to compare pregnancy and obstetric outcomes between AC-FET and NC-FET, and interaction analyses were conducted to assess whether the effects of FET protocols differed between patients with and without endometriosis.</p><p><strong>Results: </strong>In endometriosis patients, AC-FET did not differ from NC-FET in miscarriage or term birth rates. In non-endometriosis patients, however, AC-FET was associated with higher miscarriage risk and lower term birth rate. For obstetric outcomes, AC-FET increased the risks of threatened abortion, HDP, and placenta previa in endometriosis patients. There was an interaction effect between endometrial preparation methods (AC-FET and NC-FET) and with or without endometriosis on the risks of threatened abortion (P = 0.046), suggesting a stronger association between threatened abortion and AC-FET in women with endometriosis.</p><p><strong>Conclusions: </strong>AC-FET was associated with an increased risk of adverse obstetric outcomes, including threatened abortion, HDP, and placenta previa in endometriosis patients. The additive effect observed for threatened abortion underscores the need for careful monitoring during early pregnancy in this population and supports considering NC-FET for those at high risk of miscarriage.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"1047"},"PeriodicalIF":2.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal stem cells therapy for immune thrombocytopenia in pregnancy: a case report.","authors":"Tong Tong, Lida Wu, Hui Shi, Chen Song, Na Qiao, Shengjiang Tan, Yuchun Gu, Hong Gao","doi":"10.1186/s12884-025-08177-9","DOIUrl":"10.1186/s12884-025-08177-9","url":null,"abstract":"<p><strong>Background: </strong>Immune thrombocytopenia (ITP) during pregnancy poses unique therapeutic challenges due to the risk of maternal hemorrhage, fetal thrombocytopenia, and the safety limitations of standard treatments such as corticosteroids and intravenous immunoglobulin (IVIG). Mesenchymal stem cells (MSCs), particularly those derived from umbilical cord tissue (UC-MSCs), have shown immunomodulatory and hematopoietic supportive properties in refractory ITP, but their use during pregnancy has not been previously reported.</p><p><strong>Case presentation: </strong>We report the case of a 41-year-old woman with a 10-year history of ITP who conceived with a baseline platelet count of 54 × 10⁹/L at 8 weeks of gestation. During pregnancy, she self-initiated UC-MSCs infusions outside guideline-directed care (five courses, 60 × 10⁶ cells/day for three consecutive days per course), followed by two postpartum courses. Platelet counts during pregnancy were maintained between 41-94 × 10⁹/L and rose to 154 × 10⁹/L postpartum. No infusion-related adverse events were observed. The pregnancy was uneventful, with no maternal hemorrhage or fetal growth restriction, and both mother and neonate had favorable outcomes.</p><p><strong>Conclusions: </strong>This report documents the first maternal-fetal outcomes following non-standard UC-MSCs exposure in pregnancy complicated by ITP. While not medically indicated, this case highlights the reality of patient-driven use of experimental therapies and underscores the urgent need for systematic studies to evaluate maternal-fetal safety.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"1038"},"PeriodicalIF":2.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of preeclampsia by evaluating the RI of placental second villi in the third trimester with HR-Flow ultrasound.","authors":"Ye-Ping He, Jun-Lan Xu, Xiu-Feng Yin, Gang Li, Chao Xue, Yi-Feng Luo, Jian-Feng Guo","doi":"10.1186/s12884-025-08162-2","DOIUrl":"10.1186/s12884-025-08162-2","url":null,"abstract":"","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"1054"},"PeriodicalIF":2.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of preconception cannabis use frequency with cannabis use during early pregnancy.","authors":"Kelly C Young-Wolff, Felicia W Chi, Cynthia I Campbell, Monique B Does, Christina N Wysota, Deborah Ansley, Carley Castellanos, Gwen T Lapham","doi":"10.1186/s12884-025-08190-y","DOIUrl":"10.1186/s12884-025-08190-y","url":null,"abstract":"<p><strong>Background: </strong>Cannabis use during pregnancy is increasingly common and is associated with adverse health outcomes for pregnant individuals and their offspring. Identifying preconception factors that are associated with prenatal cannabis use is critical to inform early prevention and intervention. This study tested whether frequency of preconception cannabis use was associated with cannabis use during early pregnancy using data from a large healthcare system with universal screening for cannabis use.</p><p><strong>Methods: </strong>This observational study included pregnant individuals in Kaiser Permanente Northern California (KPNC) who self-reported any cannabis use (daily, weekly, or monthly or less) during the year before pregnancy from 2011 to 2022 (excluding 2020). Prenatal cannabis use was based on self-report and/or a positive toxicology test during the first trimester of pregnancy at entrance to prenatal care (at ~ 8 weeks gestation). Modified Poisson models were fit to assess associations between frequency of preconception cannabis use and prenatal cannabis use, adjusting for covariates.</p><p><strong>Results: </strong>The sample of 40,806 pregnancies from 36,622 unique individuals who self-reported any preconception cannabis use was 65.7% non-White; 27.6% were aged < 25 years. Nearly half (45.1%) screened positive for prenatal use, including 23.7% by self-report and 36.6% by positive toxicology test. Compared to monthly or less preconception cannabis use, daily use (adjusted prevalence ratio [aPR] = 2.66, 95% CI 2.59-2.73) or weekly use (aPR = 1.99, 95% CI 1.93-2.05) was associated with greater risk of prenatal cannabis use. Results were similar when prenatal cannabis use was based on self-report only or on toxicology testing only.</p><p><strong>Conclusions: </strong>Greater frequency of preconception cannabis use was associated with substantially increased risk of prenatal cannabis use. Findings reinforce the need for early harm prevention efforts focused on reducing the frequency of cannabis use among women of reproductive age, including screening, education, and early linkage to intervention.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"1044"},"PeriodicalIF":2.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network connectivity between partner factors, loneliness, and psychological distress in women with unexplained recurrent spontaneous abortion.","authors":"Zhongxuan Huang, Hang Xu, Yizhao Chen, Xingming Zhong, Fan Zhang","doi":"10.1186/s12884-025-08100-2","DOIUrl":"10.1186/s12884-025-08100-2","url":null,"abstract":"<p><strong>Background: </strong>Women experienced unexplained recurrent spontaneous abortion (URSA) are at higher risk of depression, anxiety, and other psychological disorders. Although social support showed a protective effect on the mental health among URSA women, little was known about the change and role of partnership among URSA women.</p><p><strong>Methods: </strong>151 URSA women and 215 women with healthy childbearing history were recruited. Structured questionnaires to assess participants' partnership (partner support and partner strain), loneliness, and mental health. Weighted ordinary least squares models, parallel mediation analysis and network analysis were conducted to address the roles of partnership in the group differences in mental health and loneliness.</p><p><strong>Results: </strong>URSA group reported higher levels of loneliness and psychological distress, which was partially explained by reduced partner support and increased partner strain. Network analysis showed different distributions of edge weights in mental disorder symptoms and partner factors between URSA and control group.</p><p><strong>Conclusions: </strong>The women experienced URSA are more vulnerable to mental disorders that may even jeopardize future reproductive outcomes, where the partnership quality may play a critical role. More efforts should be put into developing support service and intervention programs to improve the relationship quality for URSA couples which may benefit the couple's well-being and future pregnancy in a long term.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"1049"},"PeriodicalIF":2.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The immunological paradox of tubal ectopic pregnancy: unraveling immune tolerance amidst inflammation via single-cell sequencing.","authors":"Suming Xu, Ningxin Zhang, Yaoqin Wang, Xingyu Bi, Yonglian Wang, Xianping Wang, Pengfei Zhu, Xueqing Wu","doi":"10.1186/s12884-025-08232-5","DOIUrl":"10.1186/s12884-025-08232-5","url":null,"abstract":"","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"1045"},"PeriodicalIF":2.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical judgement processes of midwives engaged in in-hospital midwife-led births: a qualitative exploratory study.","authors":"Mami Yamamoto, Aiko Okatsu, Yaeko Kataoka","doi":"10.1186/s12884-025-08132-8","DOIUrl":"10.1186/s12884-025-08132-8","url":null,"abstract":"","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"1041"},"PeriodicalIF":2.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time series and factors associated with prematurity in live births in curitiba, brazil: time series analysis between the years 2000 and 2021.","authors":"Marcelle Fernandes Da Silva Frigotto, Isabela Cristina Santos Freire de Paula, Isabelle Cristina Daniel, Arianny de Macedo Brondani, Angela Leite Mendes, Márcia Helena Baldani, Deborah Ribeiro Carvalho, Juliana Schaia Rocha Orsi, Renata Iani Werneck","doi":"10.1186/s12884-025-08152-4","DOIUrl":"10.1186/s12884-025-08152-4","url":null,"abstract":"<p><strong>Background: </strong>Prematurity stands as the primary cause of mortality among children under the age of five globally, defined as childbirth occurring before the completion of the 37th week of pregnancy. The study aims to examine the historical prevalence and temporal trend of prematurity in Curitiba (PR) from 2000 to 2021, considering factors associated with the mother, child, and pregnancy.</p><p><strong>Methods: </strong>This quantitative, descriptive, and analytical study employs a time series approach, utilizing data from the \"COOSMIC - Curitiba Maternal and Child Health Cohort\" study conducted by the Pontifical Catholic University of Paraná in collaboration with the Curitiba Municipal Health Department. Data sourced from the Live Birth Information System (SINASC) focuses on variables including baby's sex, mother's age, schooling, and marital status, gestational age at delivery, single or multiple pregnancies, and prenatal care. In the first stage, prematurity serves as the dependent variable, while characteristics associated with the mother, child, and pregnancy are treated as independent variables over time/year using the Prais-Winsten regression model. In the second stage, the Poisson Regression model examines the association between Social Determinants of Health (SDH) and preterm births.</p><p><strong>Results: </strong>The analysis reveals an increasing trend in the prevalence of preterm births, with an Annual Significant Rate (ASR) of 2.4% (95%CI = 1.8; 3.0). Rising trends are observed across all stratifications examined, except for women lacking prenatal care visits.</p><p><strong>Conclusion: </strong>Despite the initial low historical prevalence, an upward trend in prematurity is observed. Factors such as maternal age, schooling, marital status, gestational history, and prenatal care are identified as associated factors, highlighting the necessity for targeted interventions.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"1050"},"PeriodicalIF":2.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}