BMC Pregnancy and Childbirth最新文献

{"title":"Predicting peripartum depression using elastic net regression and machine learning: the role of remnant cholesterol.","authors":"Hongxu Chen, Denglan Wang, Juanjuan Shen, Baoyan Guo, Chun Song, Duo Ma, Yan Wu, Guohui Liu, Guangxue Chen, Yan Ni, Tiantian Kong, Fan Wang","doi":"10.1186/s12884-025-07656-3","DOIUrl":"https://doi.org/10.1186/s12884-025-07656-3","url":null,"abstract":"<p><strong>Background: </strong>Traditional statistical methods have dominated research on peripartum depression (PPD), but innovative approaches may provide deeper insights. This study aims to predict the impact factors of PPD using elastic net regression (ENR) combined with machine learning (ML) model.</p><p><strong>Methods: </strong>This longitudinal study was conducted from June 2020 to May 2023, involving healthy pregnant women in the first trimester, followed up until the completion of the assessment in the second trimester. PPD symptoms were assessed using the Edinburgh Postnatal Depression Scale (EPDS). Features with p <.05 from logistic regression were selected and refined using ENR. These features were then used to build six ML models to identify the best-performing one. SHapley Additive exPlanations (SHAP) analysis was employed to enhance model interpretability by visualizing its decision-making process.</p><p><strong>Results: </strong>A total of 608 participants were followed, resulting in 384 valid questionnaires. After excluding incomplete or incorrect baseline data, 325 participants were ultimately included in the study. Among these, 130 were classified as having mild depression, and 32 were classified with major depression. Nineteen features were initially identified as being associated with PPD, with 14 retained after ENR refinement. The random forest (RF) model outperformed the other ML models. SHAP analysis identified the top five predictors of PPD: magnesium (Mg), remnant cholesterol (RC), calcium (Ca), mean corpuscular hemoglobin concentration (MCHc), and potassium (K). Mg, Ca, MCHc, and K were negatively correlated with PPD, while RC showed a positive correlation.</p><p><strong>Conclusions: </strong>The RF model effectively identified associations between exposure factors and PPD. Mg, Ca, MCHc, and K were found to be protective factors, while RC emerged as a potential risk factor, highlighting its potential as a novel biomarker for PPD.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"544"},"PeriodicalIF":2.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decision to delivery interval and predictors for delayed decision to delivery interval among women delivering by emergency caesarean section at a tertiary hospital, Southwestern Uganda: a prospective cohort study.","authors":"Julius Businge, Stuart Turanzomwe, Mathiang Agany Akol, Caxton Kakama, Rogers Kajabwangu, Michael Kanyesigye, Henry Mark Lugobe, Musa Kayondo, Joseph Ngonzi, Onesmus Byamukama","doi":"10.1186/s12884-025-07680-3","DOIUrl":"https://doi.org/10.1186/s12884-025-07680-3","url":null,"abstract":"<p><strong>Background: </strong>Emergency caesarean section (EMCS) is a life-saving procedure carried out with urgency appropriate to the risk posed to the safety of baby and/or the mother. A decision to delivery interval (DDI) is the time from making the decision for cesarean section to delivery of the neonate. Delayed DDI can result in adverse obstetric outcomes and is thus an indicator of poor quality obstetric care. This study aimed to determine the decision to delivery interval and predictors for delayed decision to delivery interval among women delivering by emergency caesarean section at Mbarara Regional Referral Hospital in South western Uganda.</p><p><strong>Methods: </strong>We conducted a prospective cohort study on women delivering by emergency caesarean section. Women with category I or II indications as per the World Health Organization (WHO) guidelines were consecutively enrolled from December 2023 to March 2024. Delayed DDI was defined as DDI interval > 75 min. We performed a modified Poisson regression analysis to determine predictors for delayed DDI.</p><p><strong>Results: </strong>A total of 504 participants were enrolled. The mean age of the respondents was 26.4 (± 5.25) years. Majority 453 (89.9%) were married, 282 (56.0%) unemployed and 271 (53.8%) had been referred in. Overall median decision to delivery interval was 167.5 min. The proportion of women with delayed DDI was 77.2% (95% CI: 73.3-80.8). Predictors for delayed DDI were prior caesarean delivery (aRR 1.15, 95%CI:1.02-1.28), need for stabilisation before surgery (aRR 1.15, 95%CI: 1.01-1.39), need to buy sundries (aRR 1.76, 95%CI: 1.20-2.57), Lack of prior communication to the theatre team (aRR 1.14, 95%CI: 1.03-1.25), unavailability of theatre operating room (aRR 1.23, 95%CI: 1.14-1.32), unavailability of sterile linen (aRR 1.18, 95%CI: 1.03-1.35) and unavailability of anaesthesia provider (aRR 1.40, 95%CI: 1.26-1.55).</p><p><strong>Conclusion: </strong>Majority of the women at MRRH experience delayed DDI and it takes about 3 h to have an EMCS. Women with a prior caesarean section, those who require stabilization before surgery, the need to buy sundries, the lack of operating room, and lack of prior communication to the theatre team, sterile linen and anaesthesia provider are predictors for delayed DDI. We recommend mobilization of resources to address these health system gaps.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"546"},"PeriodicalIF":2.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Provision of recommended antenatal care services in Ethiopia: missed opportunity for screening and counselling.","authors":"Abdulaziz Mohammed Hussen, Martin Heine, Maria Barreix, Rosemary K Muliokela, Tigest Tamrat, Özge Tunçalp, Binyam Tilahun, Diederick E Grobbee, Joyce L Browne","doi":"10.1186/s12884-025-07684-z","DOIUrl":"https://doi.org/10.1186/s12884-025-07684-z","url":null,"abstract":"<p><strong>Background: </strong>Utilisation of Antenatal care (ANC) in Ethiopia has shown a steady increase in the last two decades, from 27% in 2000 to 74% in 2019. While it is encouraging to see more women attending and receiving ANC, attention to ensuring the quality of the ANC services provided to the visiting women is important. Therefore, this study aimed to assess the provision of recommended ANC services and to identify client related factors associated with the provision of the services.</p><p><strong>Methods: </strong>The study was conducted using the 2019 Ethiopian Demographic and Health Survey (EDHS) data. Provision of recommended ANC services was assessed for the EDHS sub-set of 1573 women who had a live birth in the two years preceding the survey and at least one ANC visit. Four components of ANC (i.e. blood pressure measurement, blood and urine test, and counselling on signs of pregnancy complications) were used to measure the provision of recommended ANC services. Bivariable and multivariable analysis was performed to identify client related factors associated with the provision of recommended ANC services. An adjustment was made to account for the complex survey design throughout the analysis (weight, stratification, and clustering).</p><p><strong>Results: </strong>About one in two women (49.7%; 95% CI: 44.6-55.0) reported receiving the four components of ANC during their pregnancy. Having a higher educational level (adjusted Odds Ratio [aOR] = 2.84; 95%CI: 1.15-6.97), being in the middle (aOR = 1.87;95% CI: 1.14-3.06), richer (aOR = 2.56; 95% CI: 1.46-4.49), and richest (aOR = 4.21;95% CI: 1.93-9.21) wealth quintiles, and having two to three (aOR = 5.40;95% CI: 2.00-14.60) and four or more (aOR = 13.45; 95% CI: 4.81-37.58) ANC visits were client related factors associated with the provision of recommended ANC services.</p><p><strong>Conclusion: </strong>Despite the high ANC1 coverage, only one in two women reported receiving the four recommended services. To produce the desired health outcome from ANC utilisation, expanding the coverage should be accompanied by a strong focus on the contents and quality of care. Moreover, regardless of their educational and economic status, all women should receive all components of care as per the recommendations.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"543"},"PeriodicalIF":2.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence, management and outcomes of prolonged second stage of labour in a rural setting in Malawi: a retrospective cohort study.","authors":"Wouter Bakker, Elisabeth van Dorp, Timothy Phiri, Misheck Kazembe, Alfred Nkotola, Jos van Roosmalen, Thomas van den Akker","doi":"10.1186/s12884-025-07392-8","DOIUrl":"https://doi.org/10.1186/s12884-025-07392-8","url":null,"abstract":"<p><strong>Background: </strong>Prolonged second stage of labour may lead to maternal and perinatal complications. Options for clinical management are augmentation with oxytocin, instrumental vaginal birth or second-stage caesarean section. We aimed to describe incidence, management and outcome of prolonged second stage of labour in a rural hospital in Malawi.</p><p><strong>Methods: </strong>Retrospective analysis of medical records and partographs of all women who gave birth in 2015-2016 in a rural mission hospital in Malawi, comparing labour tracings with management protocols. Primary outcomes were incidence of prolonged second stage, instrumental vaginal birth and caesarean section. Furthermore, management and outcomes were assessed. Women arriving in hospital in the second stage of labour were compared to women arriving in an earlier stage of labour.</p><p><strong>Results: </strong>Of all 3,426 women giving birth in the study period, 566 (16.5%) presented while already in the second stage. Based on their partographs, 307 (9.0% of 3426) were diagnosed with prolonged second stage. Of these women, 22 (7.2%) had labour augmented with oxytocin, 31 (10.1%) gave birth by vacuum extraction and 64 (20.9%) by caesarean section. Spontaneous vaginal birth occurred in 212 (69.0%). Women with prolonged second stage had an increased risk of having any complication, postpartum haemorrhage being the commonest. There was no difference in neonatal outcomes between women with or without a documented prolonged second stage. Of the 566 women presenting in the second stage, 538 (95.1%) had spontaneous vaginal births and 38 (6.7%) ended up having prolonged second stage registered in their partographs.</p><p><strong>Conclusion: </strong>Prolonged second stage of labour was relatively common, and perhaps under-diagnosed due to a very sizeable proportion of women arriving whilst already in the second stage, of whom most gave birth spontaneously. Caesarean section occurred twice as often as vacuum extraction, suggesting a role for additional training and decision-making during childbirth to support the use of vacuum extraction.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"542"},"PeriodicalIF":2.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy and weight gain: a scoping review of women's perceptions and experiences with stigma.","authors":"Hima Sasidharan, Ashruti Bhatt, Manasee Mishra","doi":"10.1186/s12884-025-07650-9","DOIUrl":"10.1186/s12884-025-07650-9","url":null,"abstract":"<p><strong>Background: </strong>Weight stigma can impact any woman who considers herself as overweight, regardless of BMI. Pregnant women are at risk of experiencing stigma related to weight which harm their physical and mental health. To support and guide on healthy weight gain during pregnancy, it is important to explore women's perceptions and experiences of weight related stigma. This can inform programs and policies to improve maternal and child health outcomes. A scoping review on this issue will provide valuable insights, identify gaps in current research, and establish a foundation for informed interventions.</p><p><strong>Methods: </strong>A search syntax was created to retrieve the relevant results from PubMed and Google Scholar. A scoping review was undertaken of published peer reviewed research indexed in these databases, which were written in English, and focused only on primary studies. The methodology for this scoping review was based on the framework proposed by Arksey and O'Malley (2005) and the subsequent recommendations provided by Levac et al. (2010).</p><p><strong>Results: </strong>From a total of 3109 articles identified using search terms, 85 articles were included for review. There are four themes in this scoping review: pregnant women's perceptions and experience with healthcare givers; pregnant women's experience with family and friends; pregnant women's experience with other members of society; and pregnant women's experience with the media. Weight stigmatization can hinder the communication between healthcare providers and women leading to misunderstanding and compromising the quality of care. This can prevent women from seeking necessary care. Stigmatizing behavior of friends, family and the perpetuation of stigma in the media influences how women perceive their pregnancy weight gain, intensifies feelings of shame, isolation and negatively impacts women's mental well-being and body image during pregnancy.</p><p><strong>Conclusion: </strong>This scoping review examines the perceptions and experiences of weight stigma among pregnant women, focusing on their interactions with healthcare providers, family and friends, other members of society and stigma perpetuated by the media. The review gives an insight into how weight stigma can heighten women's stress and also leads to the avoidance of essential medical care, which affect the health of both the mother and the child. Addressing stigma from various sources is crucial for the general well-being and health of both women and children.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"541"},"PeriodicalIF":2.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidural labor analgesia is a potential risk factor for increased blood loss within two hours after delivery in women with gestational hypertension: a retrospective cohort study.","authors":"Weiguo Sun, Liping Zhou, Zhijiang Liang, Jie Jia","doi":"10.1186/s12884-025-07648-3","DOIUrl":"https://doi.org/10.1186/s12884-025-07648-3","url":null,"abstract":"<p><strong>Background: </strong>Postpartum hemorrhage remains the leading cause of maternal mortality during childbirth worldwide. Given that pregnant women with gestational hypertension are particularly vulnerable to blood volume reduction, there is currently insufficient evidence to determine whether epidural labor analgesia impacts these patients within the first 2 h postpartum.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted involving 1,903 term parturients with hypertensive disorders of pregnancy admitted to Guangdong Women and Children Hospital between January 2012 and December 2021. Participants were categorized into two groups based on receipt of epidural labor analgesia: the analgesia group (n = 884) and non-analgesia group (n = 1,019). Primary outcomes included early postpartum hemorrhage (PPH) defined as ≥ 300 mL blood loss within 2 h post-delivery and associated risk factors. Statistical analyses were performed using chi-square tests for categorical variables, Mann-Whitney U tests for continuous variables, and multivariate logistic regression to evaluate independent associations between epidural analgesia and PPH.</p><p><strong>Results: </strong>Results showed significantly higher 2-h postpartum blood loss ≥ 300 mL in epidural analgesia vs non-analgesia groups among gestational hypertension patients (54.0% vs 46.0%, P = 0.003). Multivariate analysis identified epidural analgesia as an independent risk factor for postpartum hemorrhage (adjusted OR = 1.304, 95% CI:1.013-1.680, P = 0.039). Obstetric complications including placental adhesion (OR = 2.405) and macrosomia (OR = 2.644) also correlated with hemorrhage risk (all P < 0.05). Birth canal injury demonstrated a protective association (adjusted OR = 0.63, 0.49-0.81, P < 0.001).</p><p><strong>Conclusion: </strong>Epidural labor analgesia may elevate the risk of early postpartum hemorrhage (≤ 2 h) in parturients with gestational hypertension. Clinical practice should prioritize intensive postpartum surveillance and individualized analgesic protocols to balance analgesic efficacy and hemorrhagic risk.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"538"},"PeriodicalIF":2.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Your baby has down syndrome: a reflexive thematic analysis of breaking the news to parents.","authors":"Marcela Tenorio D, Johanna Sagner-Tapia, Renata Garibaldi, Vaso Totsika","doi":"10.1186/s12884-025-07665-2","DOIUrl":"https://doi.org/10.1186/s12884-025-07665-2","url":null,"abstract":"<p><p>The communication of a Down syndrome diagnosis to mothers is a pivotal moment that can impact their emotional well-being and the subsequent care for their child. This study aimed to explore maternal experiences with receiving a Down syndrome diagnosis. A total of 40 mothers participated, 42.5% received a prenatal diagnosis, 17.5% received the diagnosis during labor and delivery, and 40% received the information at the early postnatal period. Through reflexive thematic analysis, four key themes emerged: (1) About Who and How the News Was Delivered (2), About When the News Was Delivered (3), On Where the News Should Be Delivered (4), parents' positive experiences emerging from this, predominantly, negative episode. Our findings emphasize the need for improved training for healthcare professionals in delivering sensitive diagnoses, with an emphasis on empathy, accurate information, and support resources for families.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"536"},"PeriodicalIF":2.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A plethora of laboratory protocols for vitamin D receptor (VDR) gene variants detection: a systematic review of associations with hypertensive disorders of pregnancy.","authors":"Yakubu Ibrahim, Nurul Iftida Basri, Amilia Afzan Mohd Jamil, Norshariza Nordin","doi":"10.1186/s12884-025-07510-6","DOIUrl":"https://doi.org/10.1186/s12884-025-07510-6","url":null,"abstract":"<p><strong>Introduction: </strong>Genetic variations in the vitamin D receptor (VDR) gene have been inconsistently linked to hypertensive disorder of pregnancy (HDP) across different populations. This systematic review aims to evaluate the laboratory protocols of VDR detection and association with HDP.</p><p><strong>Methods: </strong>We performed a systematic review using the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guideline and conducted an article search using the Web of Science, PubMed, Scopus, EBSCOhost (MEDLINE and CINAHL) databases. We included all studies involving one or more of the major VDR gene variants (FokI, BsmI, ApaI, and TaqI) and association with HDP.</p><p><strong>Results: </strong>Of the 9 studies evaluated, 6 (67%) studies were reported from Asia, 2 (22%) from Europe, and 1 (11%) from Latin America. Our analysis of VDR variant detection protocols revealed that approximately 6 (67%) studies used polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP), of which 3 (33%) reported a significant association with FokI variant. Two (22%) of studies used TaqMan PCR and found an association with FokI variant. Only 1 (11%) study utilised allele-specific PCR (AS-PCR) for ApaI variant genotyping. For association analysis of the variants with HDP in populations, 4 studies (44%) reported an association with FokI variant in Asians. Two studies (22%) reported BsmI variant in Caucasians. TaqI variant was not associated with HDP in all the populations studied.</p><p><strong>Conclusions: </strong>Our findings suggest an association between VDR genetic variation and HDP across different populations. To enhance consistency in these associations, future studies should use reliable detection methods and strict adherence to quality control measures. This could help in the identification of population-specific biomarkers, prevalent variants, and support personalized management strategies to reduce maternal morbidity and mortality related to HDP.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"539"},"PeriodicalIF":2.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of unintended pregnancy on maternal bonding impairment among Japanese mothers: a longitudinal study from pregnancy to one month postpartum.","authors":"Hitoshi Kaneko, Yuya Makino, Mami Nakano, Yuichiro Takahashi, Masako Matsui, Kazuyo Ogawa","doi":"10.1186/s12884-025-07642-9","DOIUrl":"10.1186/s12884-025-07642-9","url":null,"abstract":"<p><strong>Background: </strong>Numerous studies have been conducted regarding maternal bonding; however, there is a lack of studies investigating the association with unintended pregnancy. This study aimed to examine the effects of unintended pregnancy on maternal bonding using a longitudinal design from pregnancy to one month postpartum.</p><p><strong>Methods: </strong>Participants were 78 mothers who attended the Department of Obstetrics for prenatal care at 20.5 weeks of gestational age. They responded to the Postpartum Bonding Questionnaire (PBQ) and the Edinburgh Postnatal Depression Scale (EPDS). Furthermore, we asked whether the pregnancy was unintended. At one month postpartum, they responded to the questionnaires again. We performed two-way repeated-measures analysis of variance to assess the effect of group (unintended pregnancy or intended pregnancy) and time (during pregnancy or one month postpartum) on the PBQ and EPDS scores.</p><p><strong>Results: </strong>Mothers who had unintended pregnancies had significantly impaired maternal bonding compared to expected pregnancy mothers, both during pregnancy and one month postpartum. In addition, both unintended and expected pregnancy mothers had significantly decreased impaired maternal bonding at one month postpartum. Regarding depression, mothers with unintended pregnancy had significantly higher EPDS scores than mothers with expected pregnancy, both during pregnancy and one month postpartum.</p><p><strong>Conclusions: </strong>Our findings emphasize that healthcare providers should promptly identify mothers with unintended pregnancies and conduct thorough assessments of mother-infant interactions postpartum.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"540"},"PeriodicalIF":2.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of simultaneous IgM, IgG avidity, and IgA testing in diagnosis of acute toxoplasmosis in pregnant women: a systematic review and meta-analysis study.","authors":"Mostafa Tork, Mitra Sadeghi, Hossein Asgarian-Omran, Bahareh Basirpour, Somayeh Ahmadi, Fatemeh Ghasemzadeh, Shahabeddin Sarvi, Shirzad Gholami, Seyed Abdollah Hosseini, Ahmad Daryani, Sargis A Aghayan","doi":"10.1186/s12884-025-07580-6","DOIUrl":"10.1186/s12884-025-07580-6","url":null,"abstract":"<p><strong>Backgrounds: </strong>Toxoplasma gondii is a relatively common parasite with a global prevalence that can cause toxoplasmosis. This infection usually does not have clear symptoms, so timely and accurate detection plays a major role in the treatment of this disease. This study reviewed Toxoplasma antibodies dependent serologic tests in pregnancy, assessing their diagnostic effectiveness to guide healthcare providers, particularly obstetricians and gynecologists.</p><p><strong>Methods: </strong>In this systematic review and meta-analysis, we utilized four different databases for our search and adhered to the PRISMA guidelines to collect pertinent studies in duration of 2000 to April 2024. After carefully evaluating the inclusion/exclusion criteria list, we ultimately selected 67 qualifying studies for our analysis and subjecting the obtained data to statistical scrutiny.</p><p><strong>Results: </strong>Data analysis revealed that the pooled seroprevalence of IgM anti-T. gondii among pregnant women tested were 2.1% (95% CI = 1.67 to 3.03). Moreover, the weighted seroprevalence rate estimate of low IgG avidity in IgM-positive pregnant women was 30% (95% CI = 28 to 31) and the seroprevalence of IgA in IgM-positive pregnant women was 43% (95% CI = 18 to 70). Combining the IgG avidity test results with those of IgM and IgA can significantly improve the accuracy of diagnosing recent and past Toxoplasma infections.</p><p><strong>Conclusions: </strong>This approach is particularly valuable for pregnant women, as it improves the reliability of serological test outcomes and helps to provide timely treatment and mitigate irreversible complications associated with toxoplasmosis.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"537"},"PeriodicalIF":2.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}