BMC Pregnancy and Childbirth最新文献

{"title":"A mitochondrial regulator protein, mitofusin 2, is elevated in the maternal blood of women with preeclampsia.","authors":"Dandan Sun, Haijin Zhang, Yanting Wu, Jiawei Zhou, Ling Ai","doi":"10.1186/s12884-025-07663-4","DOIUrl":"10.1186/s12884-025-07663-4","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the expression of mitofusin 2 (Mfn2) in the placenta and peripheral blood of patients with early-onset preeclampsia (eoPE) and late-onset preeclampsia (loPE), and to evaluate its possibility as a diagnostic and therapeutic target for preeclampsia.</p><p><strong>Methods: </strong>A total of 68 pregnant women with preeclampsia in Jiaxing Maternal and Child Health Hospital from June 2022 to June 2024 were selected, including 32 patients with eoPE and 36 patients with loPE, and 68 term pregnant women as negative controls. Real-time fluorescence reverse transcription (RT-qPCR) was used to determine the expression level of Mfn2 mRNA in placenta and peripheral blood, and the expression of Mfn2 was analyzed; enzyme-linked immunosorbent assay (ELISA) was used to determine the level of Mfn2 in peripheral blood of patients, and the outcomes of pregnant women (placental weight, neonatal birth weight, 1 min Apgar) were recorded. The correlation between the level of Mfn2 in peripheral blood and the severity of preeclampsia and pregnancy outcomes was analyzed.</p><p><strong>Result: </strong>The expression of Mfn2 mRNA in the placenta tissue of the eoPE group was significantly lower than that of the term pregnancy group and the loPE group (P < 0.001), while the expression of Mfn2 in the placenta tissue of the loPE group was only lower than that of the term pregnancy group, with no significant difference(P > 0.05). The expression of Mfn2 mRNA in the peripheral blood of eoPE and loPE was significantly higher than that of term pregnancy group (all P < 0.001). In the peripheral blood, the levels of Mfn2 in eoPE group and loPE group were significantly higher than that of the term pregnancy group (all P < 0.001). The Pearson correlation analysis showed that the expression level of Mfn2 protein in peripheral blood of patients are positively correlated with blood pressure and urinary protein, and negatively correlated with neonatal birth weight and 1 min Apgar score.</p><p><strong>Conclusion: </strong>In early-onset placenta, the expression of Mfn2 is significantly lower than that in full-term pregnancy, while in late-onset eclampsia, it is not, indicating that the abnormal expression of Mnf2 in placenta is related to the occurrence period of preeclampsia and the progression of the disease; Mfn2 in peripheral blood can be used as a biological marker to evaluate the occurrence and progression of preeclampsia.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"567"},"PeriodicalIF":2.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in women's experiences of labour according to type of fetal monitoring: a quantitative analysis of an Australian national survey.","authors":"Kate M Levett, Deborah Fox, Panashe Bamhare, Rebecca Coddington, Kerry L Sutcliffe, Elizabeth Newnham, Vanessa Scarf","doi":"10.1186/s12884-025-07509-z","DOIUrl":"10.1186/s12884-025-07509-z","url":null,"abstract":"<p><strong>Intro: </strong>While monitoring of the fetal heart rate in labour is recommended, few studies have compared women's experiences of different forms of monitoring technologies, their impact on labour and perceived risks and benefits.</p><p><strong>Methods: </strong>The Women's experiences of Monitoring Baby (WOMB) study, an Australian national survey, examined experiences of intrapartum fetal monitoring in labour. This study is one of two quantitative analyses of survey responses received.</p><p><strong>Results: </strong>We received 861 valid responses. The most common form of monitoring across all hospital settings was wired CTG (53% of total). Women who used wired CTG were more likely to be primiparous (OR = 3.220, [95%CI:2.080-4.987], p < 0.001), and give birth at a private hospital (OR = 3.017 [95%CI:1.632-5.576], p < 0.001). Women who were monitored via wired CTG were more likely to use pharmacological pain management, and have an emergency caesarean section (p < 0.001), which remained significant when adjusting for epidural. Women who gave birth vaginally were more likely to have been monitored via intermittent auscultation (OR = 3.582, [95%CI:2.007-6.390], p < 0.001), and to use non-pharmacological techniques such as mobility (p < 0.001) and supportive care (p < 0.01). Of the women monitored via wired CTG 58% felt that monitoring had a negative impact on their labour.</p><p><strong>Conclusion: </strong>This study has substantial implications for research, policy and practice, including the implementation of less invasive and more humanised forms of fetal monitoring. The promotion of freedom of movement and bodily autonomy in labour is essential. This includes implementation of evidence-based practices and information about methods of fetal monitoring that support woman-centred care and optimise physiological processes.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"565"},"PeriodicalIF":2.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'This is like tradition, lie on your back, hold your leg, and push': understanding midwives' perspectives on their choice of labour positions in a Ugandan hospital.","authors":"Zuhaira Husna Fatma, Helle Mölsted Alvesson, Gertrude Namazzi, Josephine Babirye Kyobe, Elizabeth Ayebare","doi":"10.1186/s12884-025-07657-2","DOIUrl":"10.1186/s12884-025-07657-2","url":null,"abstract":"<p><strong>Introduction: </strong>Despite the well-documented benefits of upright positions and mobility during labour and childbirth, the adoption of these remains limited. Offering women choices in labour positions is essential for respectful maternity care. Since midwives play a pivotal role in guiding women through labour, their perspectives are crucial to the effective integration of these practices.</p><p><strong>Aim: </strong>The study aimed to understand midwives' perspectives and reasoning behind their choice of labour positions.</p><p><strong>Methods: </strong>This qualitative study was conducted in a regional referral hospital in eastern Uganda. Twelve midwives were recruited purposively at two different time points in December 2020 and February 2024. A data-driven reflexive thematic analysis was conducted.</p><p><strong>Results: </strong>Midwives' choice of labour positions was based on their understanding of the advantages and disadvantages for mothers and babies. Midwives were only open to changing their practices when they were confident in their knowledge and skills. The availability of resources influenced their perspectives on which positions were most feasible and effective in different situations. The midwives prioritised assessment of the mother's clinical condition rather than her preferences when choosing birth positions.</p><p><strong>Conclusion: </strong>This study highlighted midwives' willingness to support different and, to them, new labour positions when confident in their efficacy and safety. Addressing misconceptions about risks and equipment needs is therefore crucial. The prevailing provider-centric norms in hospitals may shape midwives' approach to care, highlighting the need for supportive environments to foster midwives' confidence in new practices.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"564"},"PeriodicalIF":2.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal plasma extracellular vesicles tsRNA as potential biomarkers for assessing preterm labor risk.","authors":"Xinrui Sun, Ying Feng, Liang Xie, Yilun Wu, Jia Mao, Yi Zhang, Linyu Zhang, Xin Yuan, Jiangping Ni, Xue Xiao, Hanmin Liu, Li Dai, Fang Ma","doi":"10.1186/s12884-025-07672-3","DOIUrl":"https://doi.org/10.1186/s12884-025-07672-3","url":null,"abstract":"<p><strong>Background: </strong>Spontaneous preterm labor (PTL) accounts for approximately 70% of preterm births, posing significant risks to both maternal and neonatal health. Current predictive biomarkers lack sufficient reliability, underscoring the need for non-invasive and dependable indicators. Emerging research indicates that tRNA-derived small RNAs (tsRNAs) are involved in various diseases; however, their potential association with PTL remains underexplored.</p><p><strong>Methods: </strong>Bioinformatics analyses of public GEO datasets (PRJNA415953 and PRJNA428989) were conducted to identify tsRNAs associated with PTL. Validation was performed using plasma extracellular vesicles samples collected at 12 weeks of gestation from PTL patients (n = 45) and healthy controls (n = 38). Functional assays were used to assess the impact of tsRNA1 (tRNA-Gly-GCC-5p-tRF-921) on extravillous trophoblast (EVT) function, including apoptosis, migration, invasion, and endothelial-like tube formation in HTR8/SVneo cells. Transcriptomic sequencing was conducted to identify tsRNA1-mediated pathways, and DNA methylation patterns were predicted based on the transcriptomic data. Statistical significance was determined using Student's t-test.</p><p><strong>Results: </strong>Two tsRNAs, tsRNA1 and tsRNA3 (tRNA-Gly-GCC-5p-tR-half-368), were significantly upregulated in PTL patient samples compared to controls. Overexpression of tsRNA1 impaired EVT function, increased apoptosis, and altered DNA methylation profiles, implicating its critical role in PTL mechanisms.</p><p><strong>Conclusions: </strong>This study identifies tsRNA1 as a key regulator of EVT dysfunction and placental pathology in PTL. The findings provide novel insights into the mechanistic role of tsRNAs in PTL and highlight tsRNA1 as a promising biomarker for early risk stratification and prediction of the condition.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"553"},"PeriodicalIF":2.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Birthing partners - validation of a questionnaire to assess the well-being of support persons.","authors":"Nadine Schmitt, Juliane Lamprecht, Sabine Striebich, Gabriele Meyer","doi":"10.1186/s12884-025-07685-y","DOIUrl":"https://doi.org/10.1186/s12884-025-07685-y","url":null,"abstract":"<p><strong>Background: </strong>There is little research on the well-being of the persons giving support during childbirth and how they feel when doing this. The aim of this study is to validate a questionnaire that assesses the well-being of those support persons during childbirth. This publication focuses on the validation of the questionnaire; the development is described in more detail in a previous publication.</p><p><strong>Methods: </strong>After the questionnaire had been developed, it was sent online to a sample for validation. Subsequently, the internal consistency was determined to assess the reliability and the correlation with an external criterion in order to assess the criterion validity. Known-groups validation was used to assess the construct validity of the questionnaire. Linear regressions were carried out to analyse which variables influence well-being.</p><p><strong>Results: </strong>The results show good reliability and high criterion validity. The known-groups analyses identified group differences between the different birth modes regarding the different domains of well-being of the support persons. Factors influencing well-being are whether it is a first time or repeated support, whether the birthing woman is a primiparous or multiparous woman and whether the birth is vaginal or operative.</p><p><strong>Conclusion: </strong>Our results suggest that this questionnaire adequately captures important aspects of the well-being of support persons during childbirth. The questionnaire is designed for all birth experiences. In the case of negative experience it can be used to assess additional support and counselling and thus potentially promote the mental health of the support persons preventively.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"561"},"PeriodicalIF":2.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of serum neuroserpin levels in pregnant women diagnosed with pre-eclampsia: a prospective case-control study.","authors":"Belgin Savran Ucok, Fahri Burcin Firatligil, Sadun Sucu, Sadullah Ozkan, Dilara Kurt, Kadriye Yakut Yucel","doi":"10.1186/s12884-025-07673-2","DOIUrl":"10.1186/s12884-025-07673-2","url":null,"abstract":"<p><strong>Objective: </strong>Neuroserpin, a serine protease inhibitor, is recognized for its anti-inflammatory and neuroprotective properties. Given the central role of inflammation and neurological involvement in the pathophysiology of preeclampsia, this study aimed to assess maternal serum neuroserpin levels in preeclamptic pregnancies and explore their association with disease severity.</p><p><strong>Design: </strong>Prospective case-control study.</p><p><strong>Setting: </strong>A tertiary referral center in Ankara, Türkiye.</p><p><strong>Population: </strong>Singleton pregnant women with a diagnosis of preeclampsia (n = 44) and gestational age-matched normotensive pregnant women as controls (n = 44).</p><p><strong>Methods: </strong>Participants were assigned to preeclampsia and control groups. Serum neuroserpin levels were quantified using enzyme-linked immunosorbent assay (ELISA). Subgroup analysis was conducted based on the clinical severity of preeclampsia. Statistical analysis included group comparisons, receiver operating characteristic (ROC) curve analysis, and correlation testing.</p><p><strong>Main outcome measures: </strong>The primary outcome was maternal serum neuroserpin level. Secondary outcomes included obstetric and neonatal parameters such as gestational age at delivery, delivery mode, NICU admission, and Apgar scores.</p><p><strong>Results: </strong>Serum neuroserpin levels were significantly reduced in the preeclampsia group compared to controls (p = 0.018). Within the preeclampsia cohort, patients with severe disease exhibited even lower neuroserpin concentrations than those with mild preeclampsia. ROC curve analysis determined a neuroserpin cutoff value of ≤ 22.95 ng/mL for identifying preeclampsia (AUC: 0.647, p = 0.013) and ≤ 14.7 ng/mL for severe preeclampsia (AUC: 0.740, p = 0.007).</p><p><strong>Conclusion: </strong>Reduced maternal serum neuroserpin levels are associated with both the diagnosis and severity of preeclampsia. These findings highlight the potential role of neuroserpin in the disease's inflammatory mechanisms and support its utility as a candidate biomarker in clinical prediction models.</p><p><strong>Clinical trial registration: </strong>Not applicable.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"559"},"PeriodicalIF":2.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring user profiles and preferences for mobile apps promoting active lifestyles during pregnancy and postpartum: cross-sectional study.","authors":"Laura Alves, Cátia Ferreira, Cristiana Mercê, Rita Santos-Rocha","doi":"10.1186/s12884-025-07635-8","DOIUrl":"https://doi.org/10.1186/s12884-025-07635-8","url":null,"abstract":"<p><strong>Background: </strong>The proliferation of mobile health applications (apps) presents promising opportunities for promoting maternal-fetal health outcomes. While numerous pregnancy-related apps exist, their alignment with user needs and evidence-based recommendations remains understudied. This study aimed to analyze the usage profile, characteristics, and preferences regarding mobile apps for promoting a healthy lifestyle during pregnancy and postpartum, with particular emphasis on physical activity.</p><p><strong>Methods: </strong>A cross-sectional retrospective study was conducted using a questionnaire titled \"Active Pregnancy App- Promoting an active and healthy lifestyle during pregnancy and postpartum,\" consisting of 36 questions in digital format via the Google Forms platform. The participants included 235 pregnant or postpartum women, with a mean age of 36 ± 4.67 years, with babies born between 2021 and 2023.</p><p><strong>Results: </strong>Among the women surveyed, 80% engaged in physical activity during pregnancy (39% 1-2 times/week), and 63% in the postpartum period. Walking was the predominant activity (90% of health/wellness activities). Most participants (87%) had never used pregnancy-specific fitness apps, despite 53% using general fitness apps. The majority considered the existence of a specific application for physical activity during pregnancy and postpartum to be important or very important. The main preferences regarding the app were: access to recommendations on an active and healthy lifestyle during pregnancy and postpartum; direct interaction with health and exercise professionals; the ability to record health and clinical parameters, physical activity, and training logs; access to guidelines on postpartum preparation and recovery programs; and workouts to perform at home and outdoors.</p><p><strong>Conclusions: </strong>User perspective is an actual trend for focusing on end users' point of view and preferences, as they are the people for whom the software is designed. The results reinforce and highlight the relevance of building a specific app for physical activity and other lifestyle parameters during pregnancy and postpartum that includes reliable and updated information, allows interaction with health and exercise professionals for monitoring, and enables the recording of progress. These results will be used in the creation and development of the \"Active Pregnancy App\" which can thus better meet the needs and demands of pregnant and postpartum women.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"558"},"PeriodicalIF":2.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relational dimension in mindfulness intervention effects: results of a randomized controlled trial of mindfulness-based childbirth and parenting.","authors":"Heidemarie K Laurent, Katherine L Haigler, Marissa D Sbrilli, Kento Suzuki, Larissa G Duncan","doi":"10.1186/s12884-025-07676-z","DOIUrl":"https://doi.org/10.1186/s12884-025-07676-z","url":null,"abstract":"<p><strong>Background: </strong>Although secular mindfulness interventions draw from contemplative traditions emphasizing relationality, evidence for impacts of such interventions on relational outcomes remains inconsistent. This study was designed to clarify conditions under which mindfulness training can improve relational functioning in a perinatal context where quality of relationship-building carries particularly important consequences for intergenerational health.</p><p><strong>Methods: </strong>We used a randomized controlled trial to test effects of prenatal participation in Mindfulness-Based Childbirth and Parenting (MBCP) vs. community birthing classes on trajectories of anxious birthing-people's individual (dispositional mindfulness, mental health, parenting stress) and relational (mindfulness in parenting, compassion, bonding with the fetus/infant) functioning across pre-intervention, post-intervention, and 3-month postnatal follow-up assessments. Multilevel growth curve models examined both main effects of intervention and moderation by participants' baseline risk and mindfulness dosage.</p><p><strong>Results: </strong>We found a main effect favoring MBCP on parenting stress only. Moderation models revealed significant effects of MBCP in predicted directions on both individual and relational outcomes for birthing-people with lower sociodemographic risk but elevated anxiety at baseline, as well as for those who engaged more with mindfulness practice both during and following the class.</p><p><strong>Conclusions: </strong>This study shows relational benefits of prenatal mindfulness training depend on birthing-people's baseline risk characteristics and practice dosage. Insight into sources of differential impact can guide further targeting and adapting mindfulness interventions to better support well-being in diverse families.</p><p><strong>Trial registration: </strong>This study was registered prospectively at ClinicalTrials.gov ID NCT05241600 (protocol identifier 19,461 starting 12/1/2018 at IL site and identifier 19,138 starting 1/26/2022 at PA site).</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"560"},"PeriodicalIF":2.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Second-trimester anthropometric estimators of cesarean section: the agreement between body roundness index, body mass index, body fat percentage, and waist circumference.","authors":"Anqi Xiong, Yan Huang, Jingyuan Ke, Shiqi Luo, Yunxuan Tong, Li Zhao, Biru Luo, Shujuan Liao","doi":"10.1186/s12884-025-07643-8","DOIUrl":"https://doi.org/10.1186/s12884-025-07643-8","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the relationships between second-trimester anthropometric obesity indicators and cesarean section (CS).</p><p><strong>Methods: </strong>A retrospective study was conducted at West China Second University Hospital, utilizing electronic health records from 15,304 pregnant women who received routine prenatal care and delivered between January 2021 and June 2022. Second-trimester anthropometric indicators, including body roundness index (BRI), body mass index (BMI), body fat percentage (BFP), and waist circumference (WC), were measured using bioelectrical impedance analysis (BIA). Logistic regression models were employed to assess the associations between these indicators and CS risk, with additional subgroup analyses based on maternal age and fetal sex.</p><p><strong>Results: </strong>The mean maternal age was 30.13 years. After adjusting for covariates, BRI (OR 1.22, 95%CI 1.15-1.30), BMI (OR 1.07, 95%CI 1.05-1.08), BFP (OR 1.03, 95%CI 1.02-1.04), and WC (OR 1.02, 95%CI 1.01-1.03) were all significantly associated with CS. Stratified analyses based on maternal age and fetal sex further confirmed these independent associations.</p><p><strong>Conclusion: </strong>Second-trimester BRI, BMI, BFP, and WC were all significantly associated with CS risk, with BRI potentially demonstrating the strongest independent correlation. An integrated approach incorporating BMI and WC is recommended for CS risk, particularly in time-sensitive or resource-limited settings. The effect of anthropometric changes during pregnancy on CS may be explored in the future.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"557"},"PeriodicalIF":2.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New first trimester circulating angiogenic biomarkers in predicting early-onset and late-onset fetal growth restriction: a case-control study.","authors":"Xiaoyi Bai, Wei Li, Wenjing Ding, Oi Ka Chan, Maran Bo Wah Leung, So Ling Lau, Daljit Singh Sahota, Chi Chiu Wang, Tak Yeung Leung","doi":"10.1186/s12884-025-07558-4","DOIUrl":"https://doi.org/10.1186/s12884-025-07558-4","url":null,"abstract":"<p><strong>Background: </strong>First trimester prediction of fetal growth restriction (FGR) remain suboptimal. We aimed to search for new circulating angiogenic biomarkers for improvement.</p><p><strong>Methods: </strong>This case-control study compared 73 singleton pregnancies with early or late-onset FGR based on Delphi consensus and 73 matched normal controls. Their maternal serum samples stored during 11-13 weeks were retrieved for measurement of 36 angiogenic biomarkers by MILLIPLEX^® human angiogenesis magnetic bead panels. Those biomarkers that showed significant differences between the study groups were further analysed with receiver operating characteristic (ROC) curve.</p><p><strong>Results: </strong>In the early-onset FGR group, log₁₀MoM of soluble neuropilin-1 (sNRP-1: 0.08 ± 0.11 vs. 0.00 ± 0.09, P < 0.001) and log₁₀MoM of soluble platelet and endothelial cell adhesion molecule 1 (sPECAM-1: 0.05 ± 0.06 vs. 0.00 ± 0.09, P < 0.05) were significantly higher than the control group, while log₁₀MoM of platelet-derived growth factor AB/BB (PDGF-AB/BB: -0.08 ± 0.13 vs. 0.00 ± 0.16, P < 0.05) and PAPP-A (-0.15 ± 0.28 vs. 0.05 ± 0.23, P < 0.001) were lower. Their combination achieved the highest area under the ROC curve (AUC) of 0.83 (95% CI: 0.74-0.95) with a higher sensitivity than that of PAPP-A alone (61.5% vs. 30.8% at 10% false positive rate, P < 0.001). Concerning the late-onset FGR group, only log₁₀MoMs of sFlt-1 (-0.12 vs. 0.00, P < 0.001) and PAPP-A (-0.07 vs. 0.05, P < 0.05) were lower than the control group, but their AUC was only 0.68 (95% CI:0.59-0.78).</p><p><strong>Conclusions: </strong>Three new first trimester biomarkers, sNRP-1, sPECAM-1 and PDGF-AB/BB are predictive of subsequent development of early-onset FGR.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"562"},"PeriodicalIF":2.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}