Elective single morula transfer achieved better clinical outcomes than two cleavage embryos transfer in fresh IVF-ET cycles.

IF 2.7 2区医学 Q1 OBSTETRICS & GYNECOLOGY

BMC Pregnancy and Childbirth Pub Date : 2025-10-21 DOI:10.1186/s12884-025-08153-3

Qing Feng, Juan Liu, Zhiwei Zhou, Jinbao Ma, Yan Song, Zhaoxia Luo, Xiaohui Ye, Lang Shen

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引用次数: 0

Abstract

Background: Assisted reproductive technology (ART) effectively treats infertility yet often results in multiple pregnancies. Optimizing clinical pregnancy rates while minimizing multiples remains challenging. Key considerations for ART providers include embryo transfer timing, number, and developmental stage. While double cleavage-stage and single blastocyst transfers are common, limited data exists on the intermediate strategy of single morula transfer.

Objective: This research aimed to assess whether elective single morula transfer (eSMT) on Day 4 yields clinical outcomes comparable to double cleavage-stage embryo transfer (DCT) on Day 3.

Methods: A retrospective propensity-matched cohort study compared DCT and eSMT in IVF, with 156 matched cases per group. Primary outcomes included clinical pregnancy rate (CPR), live birth rate (LBR), twin pregnancy rate, and preterm delivery rate. Secondary outcomes were abortion rate (AR) and cesarean section rate.

Results: After propensity score matching, no significant differences were observed between DCT and eSMT groups in CPR (75.00% vs. 69.23%), AR (16.24% vs. 14.81%), LBR (59.62% vs. 58.97%), or cesarean rate (51.61% vs. 41.30%) (all P > 0.05). The eSMT group showed significantly lower preterm delivery rates (9.78% vs. 21.51%, P < 0.05) and higher single live birth rates (58.97% vs. 43.59%, P < 0.01).

Conclusion: In patients aged ≤ 35 years, Day 4 single morula transfer demonstrates clinical pregnancy rates comparable to Day 3 double cleavage-stage embryo transfer while reducing twin pregnancy and preterm labor risks, thereby providing a safe individualized treatment strategy.

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在新鲜的IVF-ET周期中，选择性单桑葚胚移植比两个卵裂胚胎移植的临床效果更好。

背景：辅助生殖技术（ART）有效治疗不孕症，但经常导致多胎妊娠。优化临床妊娠率，同时尽量减少多胎仍然具有挑战性。ART提供者的主要考虑因素包括胚胎移植的时机、数量和发育阶段。虽然双卵裂期和单囊胚移植是常见的，但关于单桑葚胚移植的中间策略资料有限。目的：本研究旨在评估第4天选择性单桑葚胚移植（eSMT）是否能产生与第3天双卵裂期胚胎移植（DCT）相当的临床结果。方法：一项回顾性倾向匹配队列研究比较了IVF中的DCT和eSMT，每组156例匹配病例。主要结局包括临床妊娠率（CPR）、活产率（LBR）、双胎妊娠率和早产率。次要结局为流产率（AR）和剖宫产率。结果：倾向评分匹配后，DCT组和eSMT组在CPR （75.00% vs. 69.23%）、AR （16.24% vs. 14.81%）、LBR （59.62% vs. 58.97%）和剖宫产率（51.61% vs. 41.30%）方面无显著差异（均P < 0.05）。结论：在年龄≤35岁的患者中，第4天单桑葚胚移植的临床妊娠率与第3天双卵裂期胚胎移植相当，同时降低了双胎妊娠和早产的风险，从而提供了一种安全的个性化治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Pregnancy and Childbirth OBSTETRICS & GYNECOLOGY-

CiteScore

4.90

自引率

6.50%

发文量

845

审稿时长

3-8 weeks

期刊介绍： BMC Pregnancy & Childbirth is an open access, peer-reviewed journal that considers articles on all aspects of pregnancy and childbirth. The journal welcomes submissions on the biomedical aspects of pregnancy, breastfeeding, labor, maternal health, maternity care, trends and sociological aspects of pregnancy and childbirth.