BMC Pregnancy and Childbirth最新文献

{"title":"Fetal heart rate evolution patterns associated with umbilical cord abnormalities in term fetuses: a single center population-based study.","authors":"Shota Saji, Yasuyuski Mima, Masaki Yahata, Masato Ishi, Junki Koike, Junichi Hasegawa","doi":"10.1186/s12884-025-07901-9","DOIUrl":"10.1186/s12884-025-07901-9","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to estimate population-based frequencies of various fetal heart rate (FHR) evolution patterns in cases with umbilical cord abnormalities and to identify particular FHR evolution patterns associated with different types of umbilical cord abnormalities.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study. FHR evolution patterns, evaluating the trend of all FHR tracings from admission to delivery, were retrospectively analyzed and classified into five categories: persistent non-reassuring (p-NR), persistent bradycardia, Hon's pattern, reactive-prolonged deceleration (PD), and persistent reassuring. The study included pregnant women who delivered after 37 weeks of gestation. Frequencies of the five FHR evolution pattern categories were stratified by the type of umbilical cord abnormalities.</p><p><strong>Results: </strong>Among 1,195 participants, 1,074 had no cord abnormalities, and 122 had abnormalities. Overall, the prevalence of FHR patterns in cases with the cord abnormality was: 2% p-NR, 3% Hon's pattern, 21% reactive-PD, and 74% persistent reassuring. The frequencies of various FHR evolution patterns did not differ significantly between cases with and without umbilical cord abnormalities. However, when analyzing specific cord abnormalities, velamentous cord insertion showed a higher prevalence of p-NR (7% vs. 1%, p = 0.14) and reactive-PD (40% vs. 17%, p < 0.05) compared with cases without cord abnormality, along with a lower prevalence of persistence reassuring patterns (53% vs. 79%, p < 0.05).</p><p><strong>Conclusion: </strong>Analysis of FHR evolution patterns in a population-based sample demonstrated a higher occurrence of reactive-PD patterns in cases with umbilical cord abnormalities, which result in sudden deterioration of fetal condition during delivery, compared with cases without umbilical cord abnormalities.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"788"},"PeriodicalIF":2.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing patient-level risk factors for evidence-based early diagnosis of maternal sepsis.","authors":"Philip Emeka Anyanwu, Paul Expert, Kate Honeyford, Oluwasomidoyin Bello, Mobolaji Modinat Salawu, Ikeola Adeoye, Ayo Stephen Adebowale, Amen-Patrick Nwosu, Summia Zaher, Peter Ghazal, Adeniyi Francis Fagbamigbe, Magbagbeola David Dairo, Ceire Costelloe","doi":"10.1186/s12884-025-07895-4","DOIUrl":"10.1186/s12884-025-07895-4","url":null,"abstract":"<p><strong>Background: </strong>Maternal sepsis is a leading cause of maternal death, with the burden higher in low- and middle-income countries (LMICs). Early Warning Systems (EWS) combine clinical observations to identify a pattern consistent with an increased risk of clinical deterioration and have been introduced for monitoring sepsis risk. Maternal sepsis risks in LMICs are driven by factors at the health system and patient levels. This study assessed patient-level risk factors -age, health-seeking behaviour, comorbidities and procedures- associated with maternal sepsis in an urban tertiary hospital in Nigeria.</p><p><strong>Methods: </strong>We conducted a retrospective study using health records of 4,510 patients from obstetrics and gynaecology units at a tertiary hospital in southwestern Nigeria from 2016 to 2020. To examine the association between patient-level risk factors and sepsis, we analysed data for the 565 maternal patients with a record of infection using a multiple logistic regression model. We extended the model by introducing interaction terms to assess whether the association between the risk factors and maternal sepsis varied by socio-demographic factors.</p><p><strong>Results: </strong>About one-fifth of the 565 maternal patients with an infection had sepsis. Patients with sepsis had the lowest rate of live birth (29.7%) compared to those with (41.8%) and without (82.1%) an infection. Proportions of stillbirth (intrauterine fetal death) and early neonatal deaths were highest among patients with sepsis (15.3% and 1.8%) compared to those with (13.2% and 2.1%) and without (4.5% and 1.7%) an infection. Antenatal care booking status (OR: 0.17; 95% CI: 0.08-0.38) and having a catheter (OR: 2.60; 95% CI: 1.35-5.01) were significantly associated with maternal sepsis in the adjusted model.</p><p><strong>Conclusion: </strong>Our results suggest that improving access to antenatal care services for pregnant women will substantially reduce the risk of maternal sepsis in the Nigerian population. Guidelines for maternal sepsis management should consider subgroups of patients at higher risk, such as those with urethral catheters.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"782"},"PeriodicalIF":2.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal awareness, attitudes, and practices relating to green spaces and their impact on child health in Sunyani, Ghana.","authors":"Sylvester Kumi Boakye, Leslie Danquah","doi":"10.1186/s12884-025-07856-x","DOIUrl":"10.1186/s12884-025-07856-x","url":null,"abstract":"<p><p>Green Spaces have been demonstrated to hold several benefits for ecosystems and the sustenance of human health. In this hospital-based study in the Bono Region of Ghana, the researchers explore awareness, attitudes, and practices towards green spaces among 420 mothers. A cross-sectional design was employed to elicit primary data using a structured questionnaire. Following this, the study findings revealed that awareness of green spaces was relatively high among mothers; however, their attitudes and practices remained low, highlighting the need for targeted interventions to bridge this gap. The study finds that awareness was high (60%); however, less than a third of respondents exhibited a positive attitude (22%) and good practice (19%), highlighting a gap between knowledge and behavioral adoption. Multivariate regression analysis reveals that awareness was primarily determined by the highest educational level (β = 0.982) and the self-reported amount of greenery and vegetation in the respondent's neighborhood (β = -0.785). Similarly, attitudes were shaped by maternal ethnicity (β = -0.031) and household size (β = -0.116), indicating the role of socio-cultural and demographic factors. Furthermore, practices were influenced by multiple variables, including maternal age (β = 0.051), home ownership (β = 0.165), self-reported greenery in the neighborhood (β = -0.188), and the perceived quality of nearby green spaces (β = -0.059). Given these findings, policies should prioritize educating mothers on the benefits of green spaces while also enhancing accessibility and quality to encourage better utilization. In addition, the planning and establishment of green parks, green spaces, and natural vegetation in the neighbourhood and at community levels should be encouraged and intensified.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"785"},"PeriodicalIF":2.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of antepartum hemorrhage on maternal and perinatal adverse outcomes in Northern Ethiopia: a retrospective cohort study.","authors":"Mamit Gebreslassie Gebrekidan, Meseret Abay Fisseha, Aregawi Gebreyesus Belay, Girmatsion Fisseha Abreha","doi":"10.1186/s12884-025-07829-0","DOIUrl":"10.1186/s12884-025-07829-0","url":null,"abstract":"<p><strong>Background: </strong>Antepartum hemorrhage (APH) complicates 2-5% of all pregnancies and is the main cause of fetal and maternal death. However, little is known about the adverse maternal and perinatal outcomes of antepartum hemorrhage in the Tigray region. Therefore, this study assessed the effects of antepartum hemorrhage on maternal and perinatal adverse outcomes at Ayder Comprehensive Specialized Hospital, Mekelle, Tigray, Ethiopia, in 2024.</p><p><strong>Methods: </strong>An institutional-based retrospective cohort study was conducted among 539 mothers who gave birth between September 2019 and August 2021 at Ayder Comprehensive Specialized Hospital, Tigray, Ethiopia. Mothers who gave birth with and without antepartum hemorrhage were categorized as exposed and nonexposed groups, respectively. A systematic sampling method was used to select participants from medical records. Data were collected through a retrospective review of medical records. A modified Poison regression model with robust standard errors was used to estimate relative risk (RR). An adjusted relative risk (ARR) with 95% confidence interval (CI) and a p-value < 0.05 were considered statistically significant.</p><p><strong>Results: </strong>The incidence of adverse maternal outcomes among mothers with antepartum hemorrhage was 46.1%, compared to 14.2% among mothers without APH. Approximately 57.2% of mothers with APH and 18.9% of those without APH experienced adverse perinatal outcomes. Mothers with antepartum hemorrhage were more likely to experience postpartum hemorrhage (ARR = 3.9, 95% CI: 1.8, 8.8), emergency cesarean section (ARR = 2.9, 95% CI: 2.1, 3.9), preterm birth (ARR = 3.9, 95%CI: 2.8, 5.6), low birth weight baby (ARR = 4.5, 95%CI: 3.0, 6.6), stillbirth (ARR = 3.8, 95%CI: 1.9, 7.4), perinatal death (ARR = 3.7, 95%CI: 2.0, 6.9), admission to the NICU (ARR = 6.7, 95% CI: 3.1, 14.9), low Apgar score at the first minute (ARR = 2.8, 95%CI: 1.8, 4.3), and low Apgar score at the fifth minute (ARR = 3.7, 95% CI: 2.0, 6.8) compared to mothers without APH.</p><p><strong>Conclusion: </strong>Antepartum hemorrhage is associated with an increased risk of adverse maternal and perinatal outcomes; -including postpartum hemorrhage, emergency cesarean section, preterm birth, low birth weight, stillbirth, perinatal death, a low Apgar score and admission to the NICU. Improving access to emergency obstetric care in areas with a high burden of APH should be critical to ensure timely intervention and reduce adverse maternal and perinatal outcomes.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"781"},"PeriodicalIF":2.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-based prediction of preterm birth risk using methylation changes in neonatal cord blood CpG sites.","authors":"Yuxin Feng, Ying Ni, Wenkai Wang, Fen Guo, Liyu Wang, Fan Zhu, Luyao Zhang, Ying Feng","doi":"10.1186/s12884-025-07884-7","DOIUrl":"10.1186/s12884-025-07884-7","url":null,"abstract":"<p><strong>Background: </strong>Preterm birth, defined as delivery before 37 weeks of gestation, is a major cause of neonatal morbidity and mortality. DNA methylation changes at CpG sites have been associated with the risk of preterm birth.</p><p><strong>Objective: </strong>This study aimed to identify differential CpG sites in cord blood and develop predictive machine learning models based on these methylation changes to assess preterm birth risk.</p><p><strong>Methods: </strong>Methylome data from 110 neonatal cord blood samples in the GSE110828 dataset were analyzed to identify CpG sites differing between preterm and full-term births (88 for training, and 22 for testing, respectively). Key CpG sites were selected using Lasso, Elastic Net, and Random Forest. Forty-five predictive models were constructed and evaluated for accuracy, precision, recall, and F1 score.</p><p><strong>Results: </strong>Sixty-six CpG sites showed significant differences between preterm and full-term groups. Four models, including Random Forest with Lasso and Gradient Boosting with Random Forest, achieved optimal predictive performance, each with a validation accuracy of 93.75%.</p><p><strong>Conclusion: </strong>DNA methylation changes at CpG sites in cord blood are associated with preterm birth risk. CpG-based methylation models demonstrate high predictive accuracy and hold promise for early clinical risk assessment.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"784"},"PeriodicalIF":2.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating the impact of maternal anemia on low-birth-weight in Sub-Saharan African countries: propensity score matching analysis.","authors":"Bezawit Melak Fente, Angwach Abrham Asnake, Yohannes Mekuria Negussie, Zufan Alamrie Asmare, Hiwot Altaye Asebe, Beminate Lemma Seifu, Mamaru Melkam, Meklit Melaku Bezie","doi":"10.1186/s12884-025-07923-3","DOIUrl":"10.1186/s12884-025-07923-3","url":null,"abstract":"","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"783"},"PeriodicalIF":2.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unpacking childbirth expenditures: what are the factors driving extreme costs in Serbia?","authors":"Radomir Markovic, Radomir Anicic, Sladjana Benkovic, Bojana Matejic","doi":"10.1186/s12884-025-07889-2","DOIUrl":"10.1186/s12884-025-07889-2","url":null,"abstract":"<p><strong>Background: </strong>Maternity healthcare costs vary widely due to demographic, pregnancy-related, and clinical factors. Understanding the drivers of extreme costs is crucial for optimizing resource allocation and ensuring equitable access to quality maternal healthcare. This study aimed to identify factors associated with extreme hospital childbirth costs in a tertiary-level hospital in Belgrade, Serbia.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on 6,949 women who gave birth in 2019. Maternal age, parity, pregnancy characteristics, delivery method, anesthesia type, perinatal interventions, and comorbidities were analyzed. Costs were categorized as expected or extreme, and multivariate logistic regression identified significant predictors of extreme costs.</p><p><strong>Results: </strong>In our study, 4.1% of mothers required extreme-cost hospitalization and treatment, and these extreme costs were significantly more prevalent among older women, first-time mothers, preterm births, and pregnancies ending in cesarean section. Mothers with extreme costs had a median hospital stay of 23 days compared to 5 days for those with expected costs (p < 0.001). The median total cost of maternity healthcare was 604.3 USD. Women undergoing cesarean delivery had four times higher odds of incurring extreme costs compared to those with spontaneous vaginal delivery.</p><p><strong>Conclusions: </strong>Identifying cost-driving factors in maternity healthcare can improve financial planning and resource distribution in tertiary healthcare settings. Strategies to reduce unnecessary interventions, improve prenatal risk assessment, and optimize hospital stays should be explored to balance cost efficiency with high-quality maternal healthcare.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"780"},"PeriodicalIF":2.8,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remnant cholesterol in early pregnancy as a predictor of gestational diabetes mellitus beyond triglyceride levels: a retrospective cohort study.","authors":"Xiang-Xiang Li, Jia-Yi Zhang, Si-Yuan Chen, Xiao-Fei Wu, Chun-Fang Ma, Hao Shen","doi":"10.1186/s12884-025-07871-y","DOIUrl":"10.1186/s12884-025-07871-y","url":null,"abstract":"<p><strong>Background: </strong>Recent findings suggest remnant cholesterol (RC) may contribute to gestational diabetes mellitus (GDM). This study aimed to explore the link between RC and GDM in early pregnancy to assess RC's risk independently of triglycerides (TG).</p><p><strong>Methods: </strong>We performed a retrospective cohort study involving pregnant women admitted to the Suzhou Ninth Hospital affiliated to Soochow University. Data were obtained from the electronic medical record system. RC (mg/dL) was determined by subtracting high-density lipoprotein cholesterol and low-density lipoprotein cholesterol from total cholesterol. GDM was diagnosed using a 75-g oral glucose tolerance test diagnosed at 24-28 weeks of pregnancy. Various analyses, including logistic regressions, restricted cubic spline (RCS), subgroup, sensitivity, and receiver operating characteristic (ROC) analyses, were performed to evaluate the independent association between RC levels and GDM. We conducted discordance analyses to assess GDM risk in RC versus TG discordant and concordant groups using various cut points. The link between RC and different GDM subtypes was also further examined.</p><p><strong>Results: </strong>Of the 1,361 women studied, 353 (25.9%) developed GDM. After adjusting for multiple variables, RC was linked to a higher risk of GDM, with an odds ratio (OR) of 1.05 and a 95% confidence interval (CI) of 1.02-1.08. Individuals in the highest RC quartile were more likely to develop GDM (OR: 2.27, 95% CI: 1.37-3.74) than those in the lower quartile. Additionally, the adjusted RCS analysis revealed a significant linear-dose-response link between RC and GDM risk (P for all < 0.001; P for nonlinear = 0.357). Various sensitivity and subgroup analyses confirmed the robustness of our results. The discordant low TG and high RC group revealed an association with GDM, whereas the high TG and low RC group did not when compared with the low TG and low RC group. Even after adjusting for variables, the association remained significant. Similar results were observed using varying clinical cut points. In early pregnancy, RC emerged as the strongest diagnostic marker for GDM, with an ROC curve area of 0.687, surpassing other traditional lipid markers. Further analysis revealed a strong connection between early pregnancy RC levels and GDM subtypes marked solely by high fasting glucose.</p><p><strong>Conclusions: </strong>Higher RC levels were linked to GDM independently of traditional risk factors, especially TG levels, and may be more useful in diagnosing specific GDM subtypes.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"779"},"PeriodicalIF":2.8,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal diagnosis and genetic assessment of fetuses with single umbilical artery using chromosomal microarray analysis: a seven-year single-center retrospective study.","authors":"Jianlong Zhuang, Nan Huang, Yu'e Chen, Jialing Wu, Xiaofang Ye, Chunnuan Chen","doi":"10.1186/s12884-025-07886-5","DOIUrl":"10.1186/s12884-025-07886-5","url":null,"abstract":"<p><strong>Background: </strong>The inherited causes behind fetuses with a single umbilical artery (SUA) are still poorly understood, largely because published studies are scarce. In the present research, efforts were made to uncover the genetic factors at play and to assess how SUA influences pregnancy outcome.</p><p><strong>Methods: </strong>A retrospective review was performed on 5,014 pregnant individuals who underwent prenatal diagnostic testing between September 2017 and April 2023. Of these, 123 fetuses were found to have SUA. Amniocentesis was carried out in all affected cases, with samples analyzed via conventional karyotyping and chromosomal microarray analysis (CMA) to detect any chromosomal abnormalities.</p><p><strong>Results: </strong>In the present study, four cases of chromosome aneuploid and two cases of chromosomal structural abnormalities were identified through karyotype analysis, with the chromosomal aberration detection rate being 4.88% (6/123). CMA confirmed every abnormality detected by conventional karyotyping and additionally identified 11 pathogenic copy number variants that had been missed. These novel findings included clinically significant conditions such as Wolf-Hirschhorn syndrome, Xq28 duplication syndrome, 16p13.3 duplication syndrome, 16p11.2 deletion syndrome, and 22q11.21 deletion syndrome. Overall, CMA provided an incremental diagnostic yield of 8.94% (11/123) beyond what karyotyping alone achieved (P = 0.001).</p><p><strong>Conclusion: </strong>CMA markedly improved the identification of clinically relevant genetic alterations in fetuses presenting with a single umbilical artery, especially when the anomaly occurred in isolation. These findings highlight the value of CMA for uncovering the genetic contributors to SUA and advance the characterization of genotype-phenotype relationships in these cases.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"776"},"PeriodicalIF":2.8,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12275279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of exposure to ambient Ozone with sleep quality in pregnant women.","authors":"Yun Huang, Jianing Wang, Yudiyang Ma, Hong Jin, Kun Sun, Yaohua Tian, Jun Zhang","doi":"10.1186/s12884-025-07874-9","DOIUrl":"10.1186/s12884-025-07874-9","url":null,"abstract":"<p><p>No study has investigated the associations between ozone (O₃) exposure and sleep among pregnant women. This study examined the association of O₃ exposure with sleep quality in Chinese pregnant women. We analyzed data in 7,581 pregnant women. Data on O₃ exposure during different periods was obtained from ChinaHighO3 dataset. Maternal sleep quality was evaluated at enrollment using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Multivariable linear regression models were applied to explore relationships between the global score of PSQI and O₃ exposure. Logistic regression models were applied to investigate associations between O₃ exposure and the risk of poor sleep quality and sleep disturbances defined by different PSQI components. After adjusting confounders, PSQI score [and 95% confidence intervals (95%CIs)] increased by 0.24 (0.05, 0.43), 0.44 (0.23, 0.65), and 0.20 (0.12, 0.28), associated with per interquartile range increase in O₃ exposure during 3, 6, and 12 months before pregnancy, respectively. The respective odds ratios (ORs) and 95% CIs of poor sleep quality were 1.11 (0.97, 1.28), 1.27 (1.08, 1.48), and 1.12 (1.06, 1.19). O₃ exposures during different preconceptional exposure windows were associated with an increased PSQI score and a higher prevalence of poor sleep quality, longer sleep latency, and lower sleep efficiency.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"778"},"PeriodicalIF":2.8,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}