BMC Pregnancy and Childbirth最新文献

{"title":"The impact of gestational diabetes mellitus on pregnancy outcomes in women with hepatitis B virus: a retrospective cohort study.","authors":"Lan Wang, Huasong Sheng, Chen Jiang, Yiming Chen","doi":"10.1186/s12884-025-07719-5","DOIUrl":"10.1186/s12884-025-07719-5","url":null,"abstract":"<p><strong>Background: </strong>To investigate the impact of hepatitis B virus carriers combined with gestational diabetes mellitus (HBVC & GDM) on pregnancy outcomes in a cohort of pregnant women from Hangzhou, China.</p><p><strong>Methods: </strong>We set-up a retrospective cohort study to analyze data from 12,815 pregnant women who delivered in three Hangzhou tertiary hospitals between 2015 and 2022. Four groups were created according to the presence of HBV and/or GDM as follows: a non-HBVC & GDM group (n = 5,323), a HBVC group (n = 5,508), a GDM group (n = 919) and a HBVC & GDM group (n = 1,065). Univariate analysis was carried out with the Mann-Whitney U test or the chi-squared test; P < 0.05 was used as the screening criterion. Multivariate logistic regression analysis was then performed to investigate the effects of each of the relevant confounders on HBVC, GDM and HBVC & GDM. After adjusting for potential confounding variables, the results were expressed as odds ratios (ORs) and 95% confidence intervals (95% CIs), with P < 0.05 considered as statistically significant.</p><p><strong>Results: </strong>The incidence of HBVC & GDM among pregnant women in Hangzhou, China was 0.96% (95% CI: 0.90-1.02%). The median maternal age of the pregnant women in the HBVC & GDM group was significantly higher than that in the HBVC, GDM and control groups (31.00 vs. 30.00, 30.00, 29.00, P < 0.001). The proportions of low birth weight (4.0% vs. 3.8%, 3.4%, 3.4%) and macrosomia (6.8% vs. 5.4%, 3.7%, 4.3%) in the HBVC & GDM group were significantly higher than in the other three groups, with significant differences between groups (P < 0.05). Multivariate logistic analysis revealed a progressive increase in risk values with increasing maternal age in the HBVC & GDM group (OR<sub>≥ 25&<30</sub>=1.632, OR<sub>≥ 30&<35</sub>=3.257, and OR<sub>≥ 35</sub>=5.611). In addition, the carriage risk of pregnant women over 35 years was approximately two-fold higher than that in the HBVC and GDM groups (5.611/2.251 and 5.611/3.130), respectively. The risk value increased progressively with increasing gravidity (OR<sub>2</sub> = 1.364 and OR<sub>≥ 3</sub>=1.765). The risk of a floating population was as follows: Zhejiang-registered but non-Hangzhou (OR = 2.246) > outside Zhejiang Province (OR = 1.953) > Hangzhou-local (OR = 1). HBVC & GDM also increased the risk of intrahepatic cholestasis of pregnancy (ICP) (OR = 3.143, 95% CI: 2.223-4.445), pre-eclampsia (PE) (OR = 2.017, 95%CI: 1.315-3.095), macrosomia (OR = 1.548, 95% CI: 1.161-2.064), assisted vaginal delivery (OR = 1.501, 95% CI: 1.185-1.901) and Caesarean section (OR = 1.258, 95% CI: 1.035-1.528). HBVC & GDM also reduced the chance of delayed labor (gestational age > 41 week, OR = 0.217, 95% CI: 0.126-0.374).</p><p><strong>Conclusions: </strong>The incidence rates of HBVC and GDM among pregnant women in Hangzhou City are relatively high. When HBVC & GDM co-existed, the risks of ICP, PE and macrosomia increased signific","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"659"},"PeriodicalIF":2.8,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications in hospitalized neonates born to mothers with HDP subtypes: a retrospective cohort study and mediation analysis.","authors":"Qingxuan Li, Tian Wu, Yanxia Mao, Yi Yang, Yi Mu, Jun Tang, Tao Xiong","doi":"10.1186/s12884-025-07778-8","DOIUrl":"10.1186/s12884-025-07778-8","url":null,"abstract":"<p><strong>Background: </strong>Hypertensive disorders in pregnancy (HDP), including four subtypes, are common complications significantly contributing to perinatal morbidity and mortality. Research on the impact of HDP subtypes-preeclampsia/eclampsia (PE/E) and superimposed preeclampsia (SP)-on comprehensive outcomes for hospitalized neonates is relatively limited. Additionally, PE/E and SP often result in shorter gestational age (GA), and the role of GA in the preterm birth-related complications of these HDP subtypes remains unclear.</p><p><strong>Methods: </strong>This retrospective cohort study identified a total of 989 cases (exposed group), including 845 cases of PE/E and 144 cases of SP . We randomly selected 989 normotensive pregnant women from the same period as controls (control group). Adjusted odds ratios and 95% confidence intervals for neonatal outcomes were calculated using logistic regression. Mediation analysis was conducted to investigate the role of GA in the relationship between HDP subtypes and preterm birth-related complications.</p><p><strong>Results: </strong>Both PE/E and SP increased the risk of adverse birth outcomes, including preterm birth, small for gestational age, low birth weight, and asphyxia, as well as hematological complications such as neutropenia, polycythemia, and thrombocytopenia. PE/E and SP also increased the risk of hypoglycemia while decreasing the risk of pathologic jaundice, with no impact on infection complications. Mediation analysis revealed that PE/E increased the risk of intraventricular hemorrhage while reducing the risk of patent ductus arteriosus and retinopathy of prematurity, both through direct effects (the disease of PE/E itself) and indirect effects (via GA). SP increased the risk of neonatal respiratory distress syndrome and intraventricular hemorrhage through indirect effects (via GA).</p><p><strong>Conclusion: </strong>PE/E and SP are key maternal diseases influencing the outcomes of hospitalized neonates, with GA playing an important mediating role in preterm birth-related complications. Early monitoring and management of those mothers and infants are crucial to improving prognosis.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"668"},"PeriodicalIF":2.8,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and patterns of pre-existing multimorbidity in pregnancy in Northern Ireland: a population-based, retrospective study using linked routinely collected healthcare data.","authors":"Lisa Kent, Siang Ing Lee, Megha Singh, Steven Wambua, Katherine Phillips, Utkarsh Agrawal, Amaya Azcoaga-Lorenzo, Colin McCowan, Jonathon Kennedy, Holly Hope, Ngawai Moss, Rachel Plachcinski, Catherine Nelson-Piercy, Mairead Black, Sinead Brophy, Aideen Maguire, Dermot O'Reilly, Krishnarajah Nirantharakumar, Kelly-Ann Eastwood","doi":"10.1186/s12884-025-07771-1","DOIUrl":"10.1186/s12884-025-07771-1","url":null,"abstract":"<p><strong>Background: </strong>Multimorbidity in pregnancy increases health risks to women and babies, and creates challenges for services. The aim of this study was to explore the prevalence and patterns of maternal multimorbidity in a UK population.</p><p><strong>Methods: </strong>This population-based, retrospective study used individual-level, linked, routinely collected health data accessed via The Health and Social Care Northern Ireland Business Service Organisation Honest Broker Service within a Trusted Research Environment following the Five Safes Framework. Pregnancy episodes were ascertained from the Northern Ireland Regional Maternity Service Database and linked via unique Health and Care Number to secondary care diagnoses and primary care medications. Yearly prevalence (2012-2020) of multimorbidity (≥ 2 physical or mental health conditions) and complex multimorbidity (involvement of ≥ 3 organ systems) were calculated for the full cohort and stratified by age, deprivation, body mass index (BMI) and gravida. Cross-sectional analyses of prevalence and exploration of unique combinations of conditions and organ system involvement across strata were performed during a period of stability in detection rates (2014-2019).</p><p><strong>Results: </strong>The annual number of pregnancies ranged from n = 24,403 (2012) to n = 19,504 (2020). Prevalence of maternal multimorbidity ranged from 18.2% (95%CI: 17.7-18.7%) (2012) to 22.8% (95% CI: 22.3-23.4%) (2016) and mostly involved coexistence of physical and mental health conditions (range: 13.0-17.4%). Complex multimorbidity ranged from 4.0% (2012) to 6.1% (2017). The mental health system demonstrated the highest prevalence compared to all other organ systems (range: 18.6-26.2%). Multimorbidity was higher at extremes of maternal age (< 25y:24.15%; 25-34y:21.20%; ≥ 35y:23.39%), and increased with deprivation (least deprived:19.61%; most deprived:25.78%), BMI (healthy:18.37%; obesity III:39.18%), and gravida (first pregnancy:19.18%; ≥ 5 pregnancies:30.69%). Mental health multimorbidity most impacted the youngest group (< 25y:4.60%; 25-34y:1.36%; ≥ 35y:0.85%) and those who were underweight (3.73% vs 1-2% in other categories). Mental health represented the most common organ system involved in multimorbidity (18.6% of the total study population), followed by respiratory (7.3%) and dermatology (7.2%).</p><p><strong>Conclusions: </strong>Multimorbidity impacts over 1 in 5 pregnant women in NI, with complex multimorbidity affecting over 1 in 20. This may present challenges across public health, primary and community care and maternity services which offer support to women with multimorbidity throughout their reproductive journeys, from preconception through to long-term postnatal follow-up.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"666"},"PeriodicalIF":2.8,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of pregnancy health literacy on risk perception in pregnancy and pregnancy anxiety.","authors":"Abdurrahim Uyanik, Gülten Koç, Mesut Ardiç","doi":"10.1186/s12884-025-07792-w","DOIUrl":"10.1186/s12884-025-07792-w","url":null,"abstract":"<p><strong>Background: </strong>Health literacy during pregnancy is essential for maintaining and improving a healthy life. This study aims to examine the effect of health literacy on pregnancy-related anxiety and risk perception during pregnancy.</p><p><strong>Methods: </strong>This was a cross-sectional study. 204 pregnant women (24-37 weeks of gestation) were included in the study. The study data were collected using the descriptive information form, Maternal Health Literacy in Pregnancy Scale, Risk Perception in Pregnancy Scale, and Pregnancy-Related Anxiety Scale. Data were analyzed using Statistical Package for the Social Sciences (SPSS) (IBM SPSS Statistics for Windows, version 26.0. Armonk, NY: IBM Corp.) software and SPSS Amos.</p><p><strong>Results: </strong>The average age of the participants was 28.2; the average age at marriage was 22.76; and the average gestational week was 25.93. 38.7% of the participants were high school graduates. According to the study results, there were significant positive relationships between health literacy and pregnancy anxiety during pregnancy (r =.340, p <.01) and negative relationships between risk perception (r = -.212, p <.05). These findings indicate that while increased health literacy is associated with lower risk perception, it may paradoxically be linked to higher pregnancy-related anxiety.</p><p><strong>Conclusions: </strong>This study has shown that health literacy can reduce risk perception while increasing pregnancy anxiety. This situation suggests that increasing knowledge should be considered together with anxiety management.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"664"},"PeriodicalIF":2.8,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpartum depression and maternal-infant bonding: the mediating role of mentalizing and parenting self-efficacy.","authors":"Weijing Qi, Ziqi Wei, Huicong Lv, Jinping Zhao, Yuanyuan Hu, Yitong Wang, Qing Guo, Jie Hu","doi":"10.1186/s12884-025-07762-2","DOIUrl":"10.1186/s12884-025-07762-2","url":null,"abstract":"","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"667"},"PeriodicalIF":2.8,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptability of the Moyo device for intrapartum fetal heart rate monitoring at a referral hospital in Uganda: a qualitative study.","authors":"Milton W Musaba, Ritah Nantale, Julius N Wandabwa, Agnes Napyo, Albert Ssesanga, Usaama Ssewankambo, Akello Eunice, Kenneth Mugabe, Brendah Nambozo, Faith Oguttu, John Stephen Obbo, Andrew D Weeks, David Mukunya","doi":"10.1186/s12884-025-07756-0","DOIUrl":"10.1186/s12884-025-07756-0","url":null,"abstract":"<p><strong>Background: </strong>The Moyo device is an easy-to-use device that allows continuous electronic fetal heart rate monitoring (FHRM). We explored the acceptability of using the Moyo device for continuous intrapartum FHRM in Eastern Uganda.</p><p><strong>Methods: </strong>Between November 2023 and August 2024, we introduced the Moyo device for continuous intrapartum FHRM among mothers with high-risk pregnancies at Mbale Regional Referral Hospital in Eastern Uganda. We then conducted 34 in-depth interviews with 14 health workers who had used the Moyo device for continuous FHRM and with 20 mothers on whom the Moyo device was used. Participants were purposively selected and interviewed using a semi-structured interview guide. The interviews were audio recorded and transcribed verbatim. We analyzed data using thematic content analysis in Atlas ti.9 software and presented our findings using Sekhon's acceptability model.</p><p><strong>Results: </strong>Participants perceived the Moyo device as a useful and an easy-to-use tool for intrapartum FHRM. Mothers felt involved in monitoring their babies' condition, with the freedom to ambulate during labour. Moyo facilitated early detection of fetal distress, and triage of patients awaiting caesarean section in a very busy setting. The facilitators to its use were: adequate staff training, health education and counselling of mothers about the device, and tool attributes such as accuracy, reliability and being user friendly. The barriers included poor health worker attitudes, risk of cross-infection, short battery life and the device alarms that were perceived as disturbances.</p><p><strong>Conclusion: </strong>The Moyo device was acceptable to both health workers and mothers, with perceived improvements in both obstetric outcomes and birth experience. When introducing the device, careful attention needs to be paid to the training of both staff and the laboring women. Potential success of large scale roll out is supported by participants' positive attitudes toward the Moyo and high perceived effectiveness.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"658"},"PeriodicalIF":2.8,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multilevel analysis of late antenatal care booking and its predictors among pregnant women in extremely high and very high maternal mortality sub-Saharan African countries: evidence from recent demographic and health surveys data.","authors":"Tesfahun Zemene Tafere, Kaleb Assegid Demissie, Getachew Teshale, Misganaw Guadie Tiruneh, Endalkachew Dellie, Demiss Mulatu Geberu, Asebe Hagos, Nigusu Worku, Melak Jejaw","doi":"10.1186/s12884-025-07789-5","DOIUrl":"10.1186/s12884-025-07789-5","url":null,"abstract":"<p><strong>Background: </strong>Late booking of antenatal care is a major contributing factor to the high rate of maternal deaths. Despite the World Health Organization's recommendation for pregnant women to begin their first antenatal care visit within 12 weeks of gestation, delays in initiating antenatal care are common in sub-Saharan Africa. Therefore, this study intended to examine the prevalence of late antenatal care booking and its predictors in extremely high (over 1,000 maternal deaths per 100,000 live births) and very high (between 500 and 1,000 maternal deaths per 100,000 live births) maternal mortality sub-Saharan African countries.</p><p><strong>Methods: </strong>Our analysis utilized secondary data from the most recent Demographic and Health Surveys conducted between 2014 and 2022. A weighted sample of 74,552 women who had given birth within five years preceding the survey and had antenatal care visits for their last child were included. A multilevel mixed-effect logistic regression model was fitted. Statistical significance was declared at a p-value less than 0.05.</p><p><strong>Results: </strong>The pooled prevalence of late antenatal care booking in extremely high and very high maternal mortality sub-Saharan African countries was 70.16% (95% CI: 69.83,70.49). Poor wealth quantile (AOR = 1.71, 95%CI: 1.60,1.82), low community media exposure (AOR = 1.70, 95%CI: 1.63,1.78), grand multiparous (AOR = 1.66, 95%CI:1.52,1.81), no media exposure (AOR = 1.59, 95%CI, 1.52,1.67), married (AOR = 1.53, 95%CI: 1.44,1.63), middle wealth quantile (AOR = 1.41, 95%CI: 1.33,1.51), not autonomous of house-hold decision-making (AOR = 1.28, 95%CI: 1.22,1.34), multiparous (AOR = 1.27, 95%CI, 1.18,1.35), secondary education (AOR = 1.24, 95%CI: 1.16,1.34), family size of 5+ (AOR = 1.24, 95%CI:1.15,1.33), rural residence (AOR = 1.22, 95%CI: 1.15,1.30), big problem of distance (AOR = 1.20, 95%CI: 1.14,1.26), Not working (AOR = 1.17, 95%CI: 1.11,1.23), partner's no formal education (AOR = 1.17, 95%CI:1.08,1.27), age 15-24 years (AOR = 1.16, 95%CI:1.07,1.25), female household head (AOR = 0.85, 95%CI: 0.80,0.91) were significant predictors of late antenatal care booking.</p><p><strong>Conclusions: </strong>This study revealed that on average, seven in ten pregnant women in extremely high and very high maternal mortality sub-Saharan African countries booked antenatal care late. Both individual and community-level factors influenced late antenatal care booking. The study recommends empowering women, improving rural healthcare access, and promoting comprehensive ANC education and community-based interventions to address late ANC booking in extremely high and very high maternal mortality SSA countries.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"656"},"PeriodicalIF":2.8,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of obsessive compulsive behavior and breastfeeding self-efficacy on maternal satisfaction in the postpartum period: a case-control study.","authors":"Sinem Öztürkler, Nursan Çınar","doi":"10.1186/s12884-025-07739-1","DOIUrl":"10.1186/s12884-025-07739-1","url":null,"abstract":"<p><strong>Background: </strong>Mothers with preterm infants are more likely to have perinatal mood disorders than mothers carrying to term, have problems breastfeeding, and may be dissatisfied with the role of being a mother. This study was conducted to investigate and compare the effects of obsessive-compulsive (OCD) behaviour and breastfeeding self-efficacy on satisfaction with the role of motherhood. in the postpartum period in mothers of preterm or term infants.</p><p><strong>Methods: </strong>The descriptive, case-control, analytical study was conducted with 175 mothers of late preterm and 175 mothers of term. The descriptive Information Form, Scale for Obsessive, Compulsive Behaviors of Mothers in the Postpartum Period with regard to Baby Care (OCB-PPBC), The Breastfeeding Self-Efficacy Scale - Short Form (BSES-SF), and The Being a Mother Scale (BaM-13) were used as data collection tools.</p><p><strong>Results: </strong>The BSES-SF score of the mothers of term infants was higher than the mothers of late preterm infants (t=-5.147; p < 0.001), the BaM-13 score and the Child Experience sub-dimension score were lower (t = 1.988; p = 0.048 and t = 2.263; p = 0.024, respectively). A negative correlation was found between BSES-SF scores of mothers of late preterm infants and their Scale for OCB-PPBC scores (r=-0.253, p = 0.001). A negative correlation was also found between BSES-SF and BaM-13 scores of both mothers of late preterm and term infants (r= -0.343, p < 0.001 and r= -0.343, p < 0.001, repsectively). A positive correlation was found between Scale for OCB-PPBC scores and BaM-13 scores of both mothers of late preterm and term infants (r = 0.311, p < 0.001; r = 0.206 and p = 0.006, respectively).</p><p><strong>Conclusion: </strong>We believe that health professionals can contribute to increaseding maternal satisfaction with motherhood by carefully screening mothers to be for OCD behavior related to baby care in the postpartum period, improving mother-infant interaction, care practices and approaches that support maternal attachment, and supporting breastfeeding.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"652"},"PeriodicalIF":2.8,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron status at early pregnancy is associated with infectious respiratory and gastric illness in women receiving routine iron supplementation: the NuPED prospective cohort.","authors":"Caylin Goodchild, Elizabeth A Symington, Jeannine Baumgartner, Lizelle Zandberg, Amy J Wise, Cornelius M Smuts, Linda Malan","doi":"10.1186/s12884-025-07786-8","DOIUrl":"10.1186/s12884-025-07786-8","url":null,"abstract":"<p><strong>Background: </strong>Antenatal iron deficiency (ID) and anaemia, but also elevated ferritin and haemoglobin (Hb) have been associated with morbidity during pregnancy. In South Africa, pregnant women receive routine iron supplementation for anaemia prevention regardless of iron status. Our aim was to assess whether iron status at early pregnancy is associated with infectious morbidity and symptoms during pregnancy.</p><p><strong>Methods: </strong>This prospective cohort was conducted in 250 pregnant women at a public maternal and child hospital in Johannesburg, South Africa. Biomarkers of maternal iron status at < 18 weeks' gestation were measured. Women kept a symptoms diary throughout pregnancy. Associations were determined using multivariable regression models.</p><p><strong>Results: </strong>ID women had 2.6 times greater odds for experiencing gastric illness (OR: 2.642, 95% CI: 1.116, 6.255, p = 0.027). Anaemic women (Hb < 10.5 g/dL) tended to have double the duration of respiratory illness [median 15.5 (5.0, 31.0) days] compared to non-anaemic women [median 8.0 (6.0, 12.1) days], (β: 0.167, 95% CI: -0.007, 0.342, p = 0.060) and had more incidences of vomiting throughout pregnancy (p = 0.028). In the partially adjusted models, iron sufficient erythropoiesis (non-IDE) women tended to have 2.3 times increased odds for respiratory illness (OR: 2.314, 95% CI: 0.939, 5.701, p = 0.068) and there were more incidences of fever during pregnancy in the non-IDE group (p = 0.006).</p><p><strong>Conclusion: </strong>Anaemic and ID pregnant women in this largely overweight population, receiving ~ 55 mg iron daily, experience more and longer infectious morbidity, potentially related to poor iron absorption. However, although presenting with weaker evidence, iron-sufficient erythropoiesis women at early pregnancy receiving the same routine iron supplementation may have twice the risk to contract infectious respiratory illness than IDE women during pregnancy.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"657"},"PeriodicalIF":2.8,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of first-trimester serum levels of β-hCG and PAPP-A as a screening test for fetal development of intrauterine growth restriction.","authors":"Ana Ceballos Medina, Inés Gómez-Acebo, Cristina Clare Gallego de Largy, Jessica Alonso-Molero, Silvia Vilares Calvo, Juan Manuel Odriozola Feu, María Ceballos Medina, Trinidad Dierssen-Sotos","doi":"10.1186/s12884-025-07787-7","DOIUrl":"10.1186/s12884-025-07787-7","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the association between first-trimester serum levels of pregnancy-associated plasma protein-A (PAPP-A) and free beta-human chorionic gonadotropin (β-hCG) and the development of intrauterine growth restriction (IUGR), in order to assess their utility in early screening for improved perinatal outcomes.</p><p><strong>Methods: </strong>A retrospective case-cohort study was conducted at Marqués de Valdecilla University Hospital in 2021, including 119 pregnancies with IUGR and a randomly selected subcohort of 383 pregnancies from the same population. Serum levels of PAPP-A and β-hCG were analyzed both as continuous variables and as categorical variables based on population-specific percentiles (< 10th and < 5th). Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for relevant maternal and obstetric covariates.</p><p><strong>Results: </strong>Lower PAPP-A levels were significantly associated with an increased risk of IUGR, both as a continuous variable (OR = 0.50; 95% CI: 0.34-0.76, p = 0.001) and when categorized below the 10th percentile (OR = 4.01; 95% CI: 1.78-9.01, p < 0.001) and 5th percentile (OR = 4.45; 95% CI: 1.57-12.63, p = 0.005). β-hCG showed no association when analyzed continuously (p = 0.164), but values below the 10th percentile were significantly associated with IUGR (OR = 4.45; 95% CI: 1.97-10.04, p < 0.001). No reliable estimate could be obtained at the 5th percentile due to the small number of cases.</p><p><strong>Conclusion: </strong>Incorporating PAPP-A and β-hCG into first-trimester screening protocols could enable earlier identification of pregnancies at risk of IUGR, facilitating timely interventions and potentially improving maternal and neonatal outcomes. These findings support the clinical utility of these biomarkers in routine obstetric care.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"655"},"PeriodicalIF":2.8,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}