BMC Pregnancy and Childbirth最新文献

{"title":"The impact of aspirin combined with labetalol on coagulation function and pregnancy outcomes in pre-eclamptic pregnant women.","authors":"Min Zhang, Xiaoxuan Ren, Dianrong Song","doi":"10.1186/s12884-025-07314-8","DOIUrl":"10.1186/s12884-025-07314-8","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to analyze the impact of aspirin combined with labetalol on coagulation function and pregnancy outcomes in women with pre-eclampsia.</p><p><strong>Methods: </strong>A total of 98 pregnant women with pre-eclampsia admitted to our hospital from September 2019 to March 2021 were selected for the retrospective analysis. Patient records were reviewed and divided into a control group (n = 49) who received labetalol and an observation group (n = 49) who received aspirin combined with labetalol. Extracted from the case collection system and observed: clinical efficacy, occurrence of adverse pregnancy outcomes, and adverse reactions.</p><p><strong>Results: </strong>The total effective rate in the observation group was higher than that in the control group. After treatment, the observation group had lower systolic blood pressure, diastolic blood pressure, D-D, Scr, β2-MG, and MA levels compared to the control group, and higher TT, PT and APTT levels. The occurrence rate of adverse pregnancy outcomes such as preterm delivery, intrauterine distress, postpartum hemorrhage, and fetal heart abnormalities was lower in the observation group than in the control group. There were no statistically significant differences in adverse reactions such as nausea, vomiting, hypotension, ocular tremor, and facial flushing between the two groups.</p><p><strong>Conclusion: </strong>Aspirin combined with labetalol has ideal therapeutic efficacy in women with pre-eclampsia. It can enhance the antihypertensive effect, improve the coagulation status of the body, protect renal function, improve adverse pregnancy outcomes, and is considered safe and reliable, deserving adoption.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"215"},"PeriodicalIF":2.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A longitudinal study of the subjective birth experience and the relationship to mental health.","authors":"Sarah Märthesheimer, Carsten Hagenbeck, Martina Helbig, Percy Balan, Tanja Fehm, Nora K Schaal","doi":"10.1186/s12884-025-07348-y","DOIUrl":"10.1186/s12884-025-07348-y","url":null,"abstract":"<p><strong>Background: </strong>A satisfying birth experience has positive effects on the well-being of mother and child. The birth experience depends on subjective expectations and objective birth parameters, and the view of birth can also change over time. However, it is still unclear how birth anxiety and mode of birth affect the different dimensions of the birth experience in the first months after childbirth.</p><p><strong>Methods: </strong>In this prospective longitudinal study, 307 first-time mothers, planning to give birth vaginally, were assessed for fear of childbirth at approximately 34 weeks of gestation and for obstetric information. Postpartum birth experience and psychological stress was evaluated 2 days, 6 weeks and 6 months postpartum using the validated Childbirth Experience Questionnaire which comprises the four dimensions emotional experience, participation, professional support and coping possibilities, and a visual analogue scale for a global birth judgement, supplemented by the Edinburgh postpartum depression scale and the Impact of Event Scale.</p><p><strong>Results: </strong>The individual dimensions of the birth experience changed differently within the first six months. Mixed factorial ANOVAs identified a main effect of fear of childbirth for all four dimensions of the birth experience and the global birth judgment. Mode of birth influenced the dimension participation and the global judgement. For emotional experience, a complex interplay between fear of birth, birth mode and time was revealed. Correlation analyses showed significant associations between the birth experience and the psychological distress symptoms resulting from childbirth.</p><p><strong>Conclusions: </strong>Prepartum fear of childbirth affects all dimensions of the subjective birth experience, even after six months. Birth mode, on the other hand, only affects the global birth judgement and participation. The stable correlations between the different dimensions of the birth experience and maternal mental health highlight the importance of the birth experience for clinical practise.</p><p><strong>Trail registration: </strong>Registered in the German Clinical Trials Register (\"DRKS\") (No. DRKS00022177) on 22 June 2020 ( https://drks.de/search/en/trial/DRKS00022177 ).</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"216"},"PeriodicalIF":2.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatics analysis of shared biomarkers and immune pathways of preeclampsia and periodontitis.","authors":"Fangyi Ruan, Yinan Wang, Xiang Ying, Yadan Liu, Jinghui Xu, Huanqiang Zhao, Yawei Zhu, Ping Wen, Xiaotian Li, Qiongjie Zhou, Hefeng Huang","doi":"10.1186/s12884-025-07277-w","DOIUrl":"10.1186/s12884-025-07277-w","url":null,"abstract":"<p><strong>Background: </strong>Epidemiological evidence indicates that preeclampsia (PE) is associated with comorbidities such as periodontitis (PD). However, the underlying mechanism remains unclear. To enhance our understanding of their co-pathogenesis, this research investigated the shared biomarkers and pathological mechanisms.</p><p><strong>Methods: </strong>We systematically retrieved transcriptomic datasets from the Gene Expression Omnibus database. These datasets encompass a comparative analysis of the periodontium with and without PD and of the placenta with and without PE. Differentially Expressed Genes Analysis and Weighted Gene Go-expression Network Analysis (WGCNA) were used to identify the key crosstalk genes in patients with PD and PE. The functional characterisation of these genes was performed using enrichment analysis. Protein-protein interaction networks and machine learning methods were leveraged to identify shared hub genes. The XG-Boost algorithm was applied to construct diagnostic models to gain insight into disease aetiology. The identified genes were validated by single-cell RNA sequencing to ensure their robustness and biological relevance.</p><p><strong>Results: </strong>A total of 55 key crosstalk genes were identified, which were primarily enriched in immune-related pathways by using limma and WGCNA. Among them, twenty-four shared hub genes were identified using protein-protein interaction analysis and machine learning methods. The diagnostic model constructed using immune-related genes outperformed the other two models (area under the receiver operating characteristic curve [ROC] = 0.7786 and 0.7454 for PE and PD, respectively). Pathways involving these genes were mapped using the Kyoto Encyclopedia of Genes and Genomes analysis. In addition, single-cell RNA sequencing analysis showed that the expression of BIN2, LYN, PIK3AP1, and NEDD9 in neutrophils was significantly downregulated, and LYN in fibroblasts and endothelial cells was consistently upregulated.</p><p><strong>Conclusions: </strong>Shared hub genes and immunologic pathways were identified in PE and PD, characterised by crosstalk between BIN2, LYN, NEDD9, and PIK3AP1, suggesting the pathogenesis of PE and PD, which could pave the way for the development of effective diagnostic, treatment, and management strategies.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"217"},"PeriodicalIF":2.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal brain development in fetal growth restriction using MRI: a systematic review.","authors":"L Meijerink, I M van Ooijen, T Alderliesten, F Terstappen, M J N L Benders, M N Bekker","doi":"10.1186/s12884-024-07124-4","DOIUrl":"10.1186/s12884-024-07124-4","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;This systematic review investigates potential differences in brain development between growth restricted (FGR)-fetuses compared to appropriate for gestational age (AGA) fetuses using MRI.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;PubMed, Embase, Cochrane Library and Web of Science databases were searched from 1985 to 2023. FGR was defined as an estimated fetal weight (EFW) &lt; p10 and/or an abdominal circumference (AC) &lt; p10, or 20% reduction in EFW or AC using a minimum interval of two weeks. Outcomes included volumetrics, biometrics, apparent diffusion coefficients (ADC), &lt;sup&gt;1&lt;/sup&gt;H-MRS-metabolites, and oxygenation of the fetal brain. Risk of bias was assessed using Newcastle-Ottawa Scale (NOS). A meta-analysis was conducted on variables when reported in at least three studies, calculating the mean difference (MD) with a 95% confidence interval (CI).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Twenty-nine studies were included after three-phase screening, 13 used the FGR consensus definition according to the Delphi procedure. Total brain volume and cerebellar volume were significantly reduced in FGR fetuses (n = 183; 74) when compared to AGA fetuses (n = 283; 166) with a MD of -30.84 cm&lt;sup&gt;3&lt;/sup&gt; (p &lt; 0.01) and - 2.24 cm&lt;sup&gt;3&lt;/sup&gt; (p &lt; 0.01). ADC values in the frontal white matter (FWM), occipital white matter (OWM), temporal white matter (TWM), thalami, centrum semiovale (CSO), basal ganglia, pons and cerebellum, significantly lower in growth restricted fetuses (-0.07 × 10&lt;sup&gt;-3&lt;/sup&gt; mm&lt;sup&gt;2&lt;/sup&gt;/s (p &lt; 0.01); -0.06 × 10&lt;sup&gt;-3&lt;/sup&gt; mm&lt;sup&gt;2&lt;/sup&gt;/s (p &lt; 0.01); -0.07 × 10&lt;sup&gt;-3&lt;/sup&gt; mm&lt;sup&gt;2&lt;/sup&gt;/s (p &lt; 0.01); -0.10 × 10&lt;sup&gt;-3&lt;/sup&gt; mm&lt;sup&gt;2&lt;/sup&gt;/s (p &lt; 0.01); -0.06 × 10&lt;sup&gt;-3&lt;/sup&gt; mm&lt;sup&gt;2&lt;/sup&gt;/s (p &lt; 0.01); -0.07 × 10&lt;sup&gt;-3&lt;/sup&gt; mm&lt;sup&gt;2&lt;/sup&gt;/s (p &lt; 0.01); -0.07 × 10&lt;sup&gt;-3&lt;/sup&gt; mm&lt;sup&gt;2&lt;/sup&gt;/s (p &lt; 0.01); -0.02 × 10&lt;sup&gt;-3&lt;/sup&gt; mm&lt;sup&gt;2&lt;/sup&gt;/s (p &lt; 0.01); respectively). &lt;sup&gt;1&lt;/sup&gt;H-MRS showed reduced levels of N-acetyl aspartate (NAA): Choline (Cho) and NAA: Creatine(CR) levels in the frontal lobe and central brain tissue, whilst contradictive findings concerning Cho: Cr and Inositol(Ino): Cho ratios were found. Two studies investigated the cerebral hemodynamic changes in FGR fetuses showing no difference in fractional moving blood volume, similar venous blood oxygenation in the superior sagittal sinus and no difference in T2* in the fetal brain.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;MRI provides additional information on fetal brain development in a growth restricted population. Smaller total brain and cerebellar volumes and lower ADC values in the FWM, OWM, TWM, thalami, CSO, basal ganglia, pons and cerebellum have been observed in FGR. These conclusions are drawn on relatively small sample sizes with high heterogeneity resulting from diverse study populations and MRI techniques. Furthermore, how these findings correlate to long-term neurocognitive abnormalities associated with FGR remains to be elucidate","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"208"},"PeriodicalIF":2.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and correlates of depressive and anxiety symptoms among pregnant women from an urban informal settlement in Nairobi, Kenya: a community-based cross-sectional study.","authors":"Stephen Mulupi, Amina Abubakar, Moses Kachama Nyongesa, Vibian Angwenyi, Margaret Kabue, Paul Murimi Mwangi, Rachel Odhiambo, Joyce Marangu, Eunice Njoroge, Mercy Moraa Mokaya, Emmanuel Kepha Obulemire, Eunice Ombech, Derrick Ssewanyana, Greg Moran, Marie-Claude Martin, Kerrie Proulx, Kofi Marfo, Stephen Lye","doi":"10.1186/s12884-025-07339-z","DOIUrl":"10.1186/s12884-025-07339-z","url":null,"abstract":"<p><strong>Purpose: </strong>Previous research, largely from the Global North, reports high rates of common mental health disorders among women in the antenatal period, but there is paucity of such data in contexts like Kenya. This study investigated the prevalence and correlates of depressive and anxiety symptoms among pregnant women in an urban informal settlement in Kenya's capital - Nairobi.</p><p><strong>Methods: </strong>An analysis of baseline cross-sectional data from a pilot cluster randomized trial of an integrated early childhood development programme. Participants were pregnant women in their third pregnancy trimester (N = 249), residing in an urban informal settlement in Nairobi County. Mental health measures [(Patient health questionnaire (PHQ-9) and generalized anxiety disorder scale (GAD-7)] were administered alongside other sociodemographic, pregnancy, and health-related questionnaires. Linear regression analysis was performed to investigate correlates of antenatal depressive and anxiety symptoms.</p><p><strong>Results: </strong>Participant's mean age was 27.5 years (SD = 5.6). The prevalence of antenatal depressive and anxiety symptoms was 26.9% (95%CI: 21.4-32.4) and 6.4% (95%CI: 3.4-9.4), based on the PHQ-9 and GAD-7 cut-off scores of ≥ 10 respectively. Being married was a significant correlate for decreased depressive and anxiety symptoms. Higher levels of education (secondary or tertiary), history of three or more previous pregnancies, and an experience of moderate-to-extreme pain were significant correlates for elevated depressive symptoms. Similarly, tertiary level of education, history of four or more previous pregnancies, and experiencing pain were significant correlates for elevated anxiety symptoms for the pregnant women. Participants reporting feeling unwell had significantly higher anxiety symptom scores.</p><p><strong>Conclusion: </strong>In this setting, correlates of antenatal depressive and anxiety symptoms cut across demographic, pregnancy and health-related factors with implications for targeted interventions. Findings point to the need for screening of depression and anxiety as part of routine antenatal care. Further research is needed to understand these contextual correlates.</p><p><strong>Trial registration: </strong>This study was part of the integrated early childhood development pilot cluster randomised control trial, retrospectively registered in the Pan African Clinical Trial Registry on 26/03/2021, registration number PACTR202103514565914.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"213"},"PeriodicalIF":2.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal and fetal survival following Ebola, HIV and Malaria co-infection in the first trimester of gestation in resource-limited setting in Democratic Republic of Congo.","authors":"Prince Imani-Musimwa, Emilie Grant, Daniel Mukadi-Bamuleka, Zacharie Tsongo-Kibendelwa, Rigo Fraterne-Muhayangabo, Placide Mbala-Kingebeni, Richard Kitenge-Omasumbu, Olivier Nyakio-Ngeleza, Théophile Barhwamire-Kabesha, Minos Minani-Ndabahweje, Juakali Sihali-Kyolov, Richard Bitwe-Mihanda, Dieudonné Sengeyi-Mushengezi-Amani, Mija Ververs","doi":"10.1186/s12884-025-07265-0","DOIUrl":"10.1186/s12884-025-07265-0","url":null,"abstract":"<p><strong>Background: </strong>Ebola-HIV and malaria co-infection is one of the rare clinical situations that remains complex to manage even in the context of unlimited resources. In pregnancy, each of these infections can compromise maternal and fetal outcomes. The synergy of their effects on maternal immunity are often fatal, and survival is an exception, especially in a context of limited resources, such as in Ebola Treatment Units (ETUs).</p><p><strong>Case presentation: </strong>Our 22-year-old patient, weighing 56 kg and nine weeks pregnant was admitted to the ETU during the 10th outbreak in DRC. She had HIV and had abandoned antiretroviral treatment (ART) seven months before. One month before her admission, her HIV viral load was high with a low CD4⁺ T cell count. She was vaccinated against EVD with rVSV-ZEBOV four days before her symptoms. She appeared generally in ill-health but her vital signs were within normal range. Without ultrasound, the fetal vitality could not be assessed. Laboratory tests confirmed malaria, pregnancy, HIV, and Ebola infection through RT-PCR. She received supportive treatment and a neutralizing monoclonal antibody (mAb114). On the 2nd day, we observed a significant decrease in Ebola viral load. Her clinical evolution improved with no disturbance in many biological parameters. She was negative for Ebola infection on 13th day and was discharged from the ETU after three weeks of admission. After referral to a health facility an ultrasound revealed 12 weeks of gestation and lab results showed a decrease of 47% in HIV viral load with 44% CD4⁺ T cell count increase. She began ART treatment and at 38 weeks gestation, the HIV viral load was undetectable and gave birth by caesarian section to a healthy male newborn. The mother and newborn' s blood, buccal swab and adnexal samples tested negative for Ebola virus and both were discharged 10 days after the delivery.</p><p><strong>Conclusion: </strong>In case of Ebola, HIV and malaria co-infection, maternal and fetal survival remains possible even in the context of resources limited-setting. This case raises questions about the effects of the interactions of these co-infections and/or their antibodies, treatment during immune adaptation of the gravid organism.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"210"},"PeriodicalIF":2.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The traumatic childbirth experience of mothers after emergency cesarean section(EmCS) in China: a descriptive qualitative study.","authors":"Lili Ma, Mei Chan Chong, Wan Ling Lee, Huimin Yang, Yamei Lian","doi":"10.1186/s12884-025-07213-y","DOIUrl":"10.1186/s12884-025-07213-y","url":null,"abstract":"<p><strong>Background: </strong>Emergency cesarean section (EmCS) is an effective means to save the lives of the mother and fetus. Women who undergo EmCS experience sudden physiological changes and high level of psychological stress response due to its complexity, risks, and urgency. They may consider their delivery as traumatic childbirth. This study aims to understand the traumatic childbirth experience among women who underwent EmCS, as well as providing evidence for developing preventive measures in future.</p><p><strong>Methods: </strong>Sixteen women who underwent an EmCS in the past year and experienced traumatic childbirth in a tertiary hospital in Luoyang, Henan Province had participated in semi-structured, in-depth interviews between February and May 2023. Thematic analysis was used to analyze the data.</p><p><strong>Results: </strong>Four themes and ten sub-themes were extracted from the data: Theme 1: Journey from crisis to renewal: the psychological recovery process of women experienced traumatic childbirth after EmCS (stress phase, reaction phase, emotional processing and adjustment phase, and stabilization and reconstruction phase); Theme 2: Empowering mothers and families: addressing the multifaceted needs of comprehensive perinatal health education (insufficient individualized care: diversity and challenges of maternal needs, the gap in spousal involvement in perinatal health education); Theme 3: The barriers between patient-professional communication in healthcare (breaking the silence: needs to address the ineffective communication, beyond the diagnosis: needs for empathy in healthcare); and Theme 4: Limited family support (the forgotten mothers, husbands' emotional absence).</p><p><strong>Conclusions: </strong>This study contributed to our understanding of the childbirth process for women undergoing EmCS. Women in this period experienced a range of negative emotions, they were lacking in sufficient health education, good communication between healthcare professionals and adequate family support. The research findings are valuable for us to identify their difficulties and needs, enabling us to provide assistance.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"209"},"PeriodicalIF":2.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of fear of childbirth and postpartum depression with perceived partner response during pregnancy.","authors":"Bingfen Li, Tong Liu, Di Ma, Jingli Sun, Jinsong Liu","doi":"10.1186/s12884-025-07332-6","DOIUrl":"10.1186/s12884-025-07332-6","url":null,"abstract":"<p><strong>Background: </strong>Fear of childbirth may affect delivery experience and postpartum recovery, and even lead to postpartum depression. Spouses, as the primary caregivers of pregnant women, are an important source of emotional support and have a significant impact on their psychological adjustment. The aim of this study is to explore the association of fear of childbirth and postpartum depression with perceived partner response during pregnancy.</p><p><strong>Methods: </strong>A longitudinal study was conducted at the Northern Theater Command General Hospital from June 2023 to April 2024. 289 pregnant women completed two surveys in total. The questionnaire included the Childbirth Attitude Questionnaire, the Edinburgh Postnatal Depression Scale, and the Perceived Partner Responsiveness Scale. Latent class analysis was used to identify categories of postpartum depression. The moderating effect was analyzed by multiple linear regression analysis, and visualized by simple slope analysis.</p><p><strong>Results: </strong>Postpartum depression was classified into three types: \"Low postpartum depression -Insomnia and sadness group\" (46.5%), \"Moderate postpartum depression -Anxiety and crying group\" (42.6%), and \"High postpartum depression -Emotional suppression group\" (10.9%). The interaction term (fear of childbirth*perceived partner response) has a significant impact on postpartum depression (ΔR² = 0.047, β = 0.226, P < 0.01), indicating a moderating effect. The effect of fear of childbirth on postpartum depression was gradually decreased in the low (Mean-SD), mean, and high (Mean + SD) groups of perceived partner response (P < 0.01).</p><p><strong>Conclusions: </strong>Pregnant women had three characteristics of postpartum depression, and the overall rate was relatively high. The perceived partner response can effectively regulate the association of fear of childbirth and postpartum depression during pregnancy.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"211"},"PeriodicalIF":2.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expectant and new fathers say they need resources and sources of support.","authors":"Derek M Griffith, Emily C Jaeger, Perri Pepperman, Karen A Chustz, Deborah Frazier, Amber Wilson","doi":"10.1186/s12884-025-07290-z","DOIUrl":"10.1186/s12884-025-07290-z","url":null,"abstract":"<p><strong>Objectives: </strong>It is critical to exhaust the range of opportunities to reduce racial inequities in maternal mortality. Developing interventions to optimize how fathers can support mothers during pregnancy and childbirth remains under developed, particularly in the context of racial inequities. In this study, we collected formative data from expectant and new fathers to identify the types of supports and resources they need to promote positive maternal health outcomes.</p><p><strong>Design: </strong>We used a phenomenological thematic approach to analyze data from 80 new fathers in 10 focus groups from five of the six Alliance for Innovation Maternal Community Care Initiative sites across the United States, collected between November 2021 and April 2022. The majority (86.25%) of fathers were Black American and their average age was 33.9 years (range 24-61 years old).</p><p><strong>Results: </strong>Four key themes characterize the types of information and resources expectant and new fathers sought and wanted: (a) baby's development and mother's mental and physical needs; (b) financial needs and family planning; (c) navigating the healthcare and social systems; and (d) mental health resources for both parents. Fathers sought the counsel, advice, and support of a variety of people, but who they asked for support depended on the issue. Expectant and new fathers sought information pertaining to being a breadwinner, fulfilling the father role, being a supportive partner, and general information on caring for a newborn. Most fathers felt that the healthcare system and social service systems lacked information and resources tailored to their needs, and they were generally ill-equipped to consider fathers or support them.</p><p><strong>Conclusion: </strong>Fathers sought information and resources to facilitate their roles as fathers and to enhance their ability to support expectant and new mothers. It is important to hear from fathers and to utilize their feedback to inform social service system changes and other organizational or institutional resources, programs, and policies to optimize their efforts to promote maternal health and to reduce maternal mortality. Expectant and new fathers needed better access to reliable, accurate, and readily-available information to prepare and support them in their new roles, responsibilities, and lives.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"205"},"PeriodicalIF":2.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embryonic and neonatal outcomes following double vitrification/thawing: a systematic review and meta-analysis.","authors":"Arezoo Maleki-Hajiagha, Anahid Shafie, Saeede Rezayi, Mahnaz Marvi, Rana Karimi, Fardin Amidi","doi":"10.1186/s12884-025-07311-x","DOIUrl":"10.1186/s12884-025-07311-x","url":null,"abstract":"<p><strong>Objectives: </strong>This systematic review and meta-analysis aimed to evaluate the impact of double vitrification/thawing (DVT) versus single vitrification/thawing (SVT) on key embryonic and neonatal outcomes.</p><p><strong>Data extraction: </strong>Information sources included systematic search in PubMed, Scopus, and Cochrane databases up to September 7, 2024. Data from each qualifying study were extracted by two reviewers using a standardized electronic data gathering form.</p><p><strong>Data analysis: </strong>Mantel-Haenszel odds ratio (MHOR) and mean difference (MD) with 95% confidence intervals (CI) were calculated using both fixed and random-effects models. Subgroup analyses were based on biopsy status, number of biopsy rounds, extended culture between rounds of vitrification, and embryo transfer strategy.</p><p><strong>Results: </strong>A total of 35 studies involving 46,749 embryo transfer cycles were included. After excluding studies that used slow freezing, 28 studies were included in the meta-analyses. The findings indicated that DVT is associated with significant reductions in cryosurvival rates (MHOR: 0.4; CI: 0.3 to 0.8; P < 0.01), biochemical pregnancy (MHOR: 0.7; CI: 0.6 to 0.8; P < 0.01), clinical pregnancy (MHOR: 0.7; CI: 0.5 to 0.8; P < 0.01), and live birth rates (MHOR: 0.6; CI: 0.5 to 0.7; P < 0.01). Additionally, there was a significant increase in the miscarriage rate (MHOR: 1.4; CI: 1.2 to 1.7; P < 0.01). No significant differences were found in neonatal outcomes.</p><p><strong>Conclusion: </strong>Poor-quality evidence suggests that the transfer of double-vitrified embryos might be associated with significantly lower rates of cryosurvival, pregnancy, and live births; however, it does not appear to affect neonatal outcomes such as birth weight and gestational age at birth. Given the small sample size in some subgroups, the high risk of selection, confounding and missing data biases, and the high level of heterogeneity for some outcomes, these findings should be interpreted cautiously.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"206"},"PeriodicalIF":2.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}