BMC Pregnancy and Childbirth最新文献

{"title":"Missed care in neonatal intensive care unit: effect of electronic reminders.","authors":"Bahrami Fereshteh, Azizzadeh Forouzi Mansooreh, Nematollahi Monirsadat, Kalisch Beatrice, Bagherian Behnaz","doi":"10.1186/s12884-025-07647-4","DOIUrl":"10.1186/s12884-025-07647-4","url":null,"abstract":"<p><strong>Background: </strong>Missed nursing care is a newly defined concept and refers to any aspect of required patient care that is omitted or delayed. This study aimed to determine the effectiveness of electronic reminders on missed care in NICU.</p><p><strong>Method: </strong>This is a two groups (before and after) quasi experimental study. A random sampling technique was employed to collect a sample of 70 nurses among two NICUs in an educational hospital in the south east of Iran. Miss care questionnaire was used to determine Missed care before, immediate, and one month after the intervention. The study intervention includes sending electronic reminders regarding nursing care of NICU hospitalized neonate. Data were analysed using SPSS₂₀ software, descriptive (frequency, percentage, mean, and standard deviation), and analytical statistics. The level of significance was considered as 0.05.</p><p><strong>Results: </strong>The results showed that the mean score of missed care was decreased after intervention in the intervention group (6.74 ± 8.47) rather than the control group (18.57 ± 14.59) (P = 0.001). The highest and the lowest mean score of missed care before and after the intervention was in general care and oxygen therapy domains in both groups. The second time intervention was one month after did not show any significant differences in the two groups. But decreasing in missed care was shown in both groups.</p><p><strong>Discussion: </strong>Using informational technologies like WhatsApp is an easy, low cost and available method which could help nurses decrease missed nursing care. More studies with a longer duration could probably have a greater impact on reducing missed care.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"615"},"PeriodicalIF":2.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From prenatal detection to postnatal evaluation: a retrospective observational ultrasound study of patent urachus with allantoic cyst.","authors":"Lanxin Du, Xinyue Jing, Ying Tang, Houqing Pang, Xiayu Yan, Lu Ye, Hong Luo","doi":"10.1186/s12884-025-07728-4","DOIUrl":"10.1186/s12884-025-07728-4","url":null,"abstract":"<p><strong>Background: </strong>Patent urachus with allantoic cyst (PUAC) is a rare abnormal embryonic development characterized by a prenatal umbilical mass and postpartum bladder prolapse. The current literature is mainly case reports, and there is a lack of consecutively observational studies of this disease.</p><p><strong>Objectives: </strong>This study aims to investigate the impact of the disease on fetal development through a retrospective analysis of prenatal ultrasound progression, pregnancy outcomes, and postnatal follow-up, thereby establishing an evidence-based foundation for prenatal clinical recommendations.</p><p><strong>Materials and methods: </strong>We performed a retrospective analysis of cases identified between January 2012 and December 2022, in which first-trimester sonographic screening demonstrated an umbilical cystic mass with anechoic tubular connections to the fetal bladder. Detailed clinical information about the pregnant individuals, prenatal ultrasonographic changes, genetic outcomes, abdominal appearance of newborns and stillbirths, comorbidities, surgical repair and neonatal follow-up were meticulously recorded and analyzed.</p><p><strong>Results: </strong>Nine cases met the ultrasound inclusion criteria. Except for one lost to follow-up in second trimester, the remaining eight cases were confirmed as PUAC after birth or induction. Serial ultrasonography demonstrated progressive enlargement of the allantoic cysts with advancing gestational age, culminating in rupture during the second or third trimester and subsequent umbilical mass formation. In postnatal analysis, prolapsed bladder was identified as the predominant component of the umbilical mass, with intestinal involvement observed in some cases. Transient or persistent dilatation of the renal pelvis occurred in over 50% of the fetuses. During long-term follow-up, patients were observed to experience abdominal pain, urinary frequency, and urinary tract infections, with one case showing bilateral vesicoureteral reflux. Only one case showed abnormal genetic results, specifically a 17p12 duplication, which can lead to Charcot-Marie-Tooth syndrome Type 1 A (CMT1A).</p><p><strong>Conclusion: </strong>This study highlights that isolated PUAC represents a fetal condition with a favorable prognosis. Dynamic prenatal ultrasound monitoring allows serial documentation of umbilical lesion progression, critically providing assistance for postpartum surgical intervention and prenatal counseling.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"614"},"PeriodicalIF":2.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12108017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colostrum avoidance and associated factors among mothers of children under the age of six months in Sekota Zuria woreda, Waghimra zone, Ethiopia.","authors":"Fitsum Zekarias Mohammed, Mulugeta Desalegn Berie, Abinet Dagnaw Mekuria, Sadat Mohammed Yesuf, Besufekad Mulugeta Urgie","doi":"10.1186/s12884-025-07717-7","DOIUrl":"10.1186/s12884-025-07717-7","url":null,"abstract":"<p><strong>Background: </strong>Early initiation of breastfeeding (EIBF) and exclusive breastfeeding (EBF) are critical practices for ensuring optimal early-life and long-term well-being among human populations, particularly in resource-limited settings. Although Ethiopia enjoys a high rate of breastfeeding (BF) overall, common practices, such as colostrum avoidance, impede the nation from attaining the BF targets set by the World Health Organization (WHO).</p><p><strong>Objective: </strong>To assess colostrum avoidance and its associated factors among mothers of children under the age of six months in the Sekota Zuria Woreda of the Waghimra Zone, Ethiopia, 2022.</p><p><strong>Methods: </strong>A community-based cross-sectional study was conducted between June 26 and July 30, 2022, in the Sekota Zuria Woreda of the Waghimra Zone, Ethiopia. The study included 421 mothers of children under the age of six months, selected using a multistage sampling technique. Once written consent was obtained from all participants, a pretested and reliability-checked questionnaire was employed to interview and gather data. During the analysis, descriptive statistics and logistic regression models were employed to summarize and explore the statistical associations between the dependent and explanatory variables. In the bivariate logistic regression analysis, variables with a P-value of < 0.25 were exported to the multivariate logistic regression model for further analysis. Finally, using a P-value of < 0.05 as an indicator of statistical significance, the Adjusted Odds Ratio (AOR) at 95% Confidence Intervals (CI) was calculated.</p><p><strong>Results: </strong>According to this study, 19.0% (95% CI: 15.0-22.8%) of the mothers in Sekota Zuria Woreda avoided colostrum. In addition, mothers who did not receive Antenatal Care (ANC) (AOR = 2.9, 95% CI: 1.1-7.8), gave birth at home (AOR = 4.6, 95% CI: 2.0-10.8), lacked participation in the Women's Health Developmental Army (WHDA) (AOR = 4.7, 95% CI: 1.9-11.4), gave pre-lacteal feeds (AOR = 3.0, 95% CI: 1.2-7.1), had insufficient knowledge (AOR = 3.0, 95% CI: 1.2-7.6), and had a negative attitude toward colostrum feeding (AOR = 6.5, 95% CI: 3.0-14.2) were more likely to avoid colostrum.</p><p><strong>Conclusions: </strong>In Sekota Zuria Woreda, the prevalence of colostrum avoidance is high, with nearly one in five mothers withholding colostrum from their newborns. This practice is primarily driven by poor utilization of healthcare services, lack of participation in the WHDA, inadequate knowledge, and negative attitudes toward colostrum. Creating an environment that encourages, enables, and supports mothers to utilize healthcare services and participate in the WHDA while also improving their knowledge and attitudes toward colostrum is crucial for decreasing the prevalence of colostrum avoidance in the Woreda.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"605"},"PeriodicalIF":2.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Hypertensive Disorders of Pregnancy (HDP) on maternal and perinatal birth outcomes in Eastern Ethiopia: a prospective cohort study.","authors":"Ebisa Zerihun, Firaol Girma, Nimona Amena, Wubet Tazeb Wondie, Belete Feyera Olkaba, Lemma Mideksa Egu, Solomon Seyife Alemu, Gemechu Gelan Bekele, Belay Tafa Regassa, Meseret Robi Tura, Fekadu Abera Kebede","doi":"10.1186/s12884-025-07707-9","DOIUrl":"10.1186/s12884-025-07707-9","url":null,"abstract":"<p><strong>Background: </strong>Globally, hypertensive disorders of pregnancy are the major causes of maternal and perinatal morbidity and mortality. In low and middle-income countries, including Ethiopia, studies on the effect of hypertensive disorders of pregnancy on maternal and perinatal birth outcomes are limited.</p><p><strong>Objectives: </strong>The aim of this study was to examine the effect of hypertensive disorders of pregnancy on maternal and perinatal birth outcomes in Eastern Ethiopia.</p><p><strong>Methods: </strong>We employed a prospective cohort study design involving 374 pregnant women, equally divided into hypertensive ((n = 187) and normotensive (n = 187). Data were collected face to face using an interviewer-administered questionnaire as well as by reviewing the medical records of the mothers. Data analysis was done in STATA Version 17. Binary logistic regression was run to produce risk ratios (relative risk) and 95% confidence intervals along with their p-values were calculated in the bivariate and multivariable analyses. Significance was declared at a P-value of less than 0.05.</p><p><strong>Results: </strong>Compared with normotensive, women with hypertensive disorder had significantly increased risk of developing preterm birth (cRR = 1.8; 95% CI, 1.5, 2.2), stillbirth (cRR = 1.6; 95% CI, 1.3, 2.02), low birth weight (cRR = 1.9; 95% CI, 1.6, 2.3), and early neonatal death (cRR = 1.7; 95% CI, 1.3, 2.3). Women with hypertensive disorders had 2.6 times (aRR = 2.6, 95% CI; 1.2, 5.7) higher risk of perinatal death, and 1.7 (aRR = 1.7; 95%CI, 1.02, 2.90) times higher risk of cesarean section delivery compared with the normotensive women controlling the other variables.</p><p><strong>Conclusion: </strong>Significant risk of cesarean section delivery, perinatal death, stillbirth, low birth weight delivery, and early neonatal death were reported among women with hypertensive disorders of pregnancy. To minimize the burden of the problem, much has to be done by health care professionals and stakeholders focusing on the identification and proper management of mothers with hypertensive disorders.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"606"},"PeriodicalIF":2.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of maternal isolated oligohydramnios on blood metabolic profile in term neonates: a retrospective observational study.","authors":"Qiuping Yang, Zhirong Deng, Guixian Pan, Congcong Shi, Jie Li, Li Zhou, Ximei Yang, Guiying Zhuang, Bingqing Liu, Jie Song, Yao Cai","doi":"10.1186/s12884-025-07729-3","DOIUrl":"10.1186/s12884-025-07729-3","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to compare the blood metabolism status of newborns with maternal-isolated oligohydramnios (IO) and normal amniotic fluid and investigate the relationship between IO and fetal health.</p><p><strong>Methods: </strong>Blood metabolites of 60 neonates with maternal IO and 60 healthy controls (HC) admitted to The Sixth Affiliated Hospital, Sun Yat-sen University (a discovery set), were analyzed using liquid chromatography-mass spectrometry to identify differential metabolites. Pathway analysis was performed to identify the most enriched metabolic pathways in discovery set. The discriminant metabolites were further verified in an independent set consisting of 50 neonates with maternal IO and 60 HC admitted to The Maternal and Child Health Care Hospital of Huadu.</p><p><strong>Results: </strong>The blood metabolic profile of newborns with IO was significantly different from that of HC. Differential metabolites were mainly enriched in Phe, Tyr and Trp biosynthesis. Levels of Phe, Tyr and Trp were significantly lower in IO neonates which found in the discovery set, and were verified in the validation set.</p><p><strong>Conclusions: </strong>The difference in the blood metabolomics profiles between neonates with maternal IO and HC was mainly in the pathway of Phe, Tyr and Trp biosynthesis. Phe, Tyr, and Trp biosynthesis may be involved in the physiological processes related to the nervous system and digestive system. Continuous attention to changes in blood metabolites in IO neonates and the effect on body growth and development is necessary.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"611"},"PeriodicalIF":2.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value-based evaluation of gestational diabetes mellitus care pathway redesign by using cost and outcome data.","authors":"Maud van den Berg, Julia Spaan, Jacoba van der Kooy, Monique Klerkx, Charlotte Krol, Arie Franx, Kees T B Ahaus, Hilco J van Elten","doi":"10.1186/s12884-025-07576-2","DOIUrl":"10.1186/s12884-025-07576-2","url":null,"abstract":"<p><strong>Background: </strong>Gestational diabetes mellitus (GDM) is a common complication of pregnancy. Implementation of Value-Based Healthcare (VBHC) to GDM care is worthwhile as traditional GDM care is fragmented and fails to meet the needs of women with GDM. Value of care can be improved through optimization and redesign of the care pathway and implementation of an outcome-based payment model. This study was conducted to perform a value-based evaluation of GDM care pathway redesign by using cost- and outcome data.</p><p><strong>Methods: </strong>This study was designed as a single center, prospective, observational cohort study. In January 2022, GDM care was redesigned by substituting GDM care activities from an Internal Medicine Department (IMD) to an Integrated Maternity Care Organization (IMCO) in the Netherlands. Women diagnosed with GDM in 2021 were assigned to a pre-intervention cohort (N = 264) and those diagnosed in 2022 to a post-intervention cohort (N = 407). The impact of the intervention on value of care for women with GDM was evaluated by comparing clinical outcomes, patient-reported experience measures (GDM Responsiveness questionnaire), and costs (Time-Driven Activity-Based Costing) between the cohorts.</p><p><strong>Results: </strong>Referrals to the IMD for GDM decreased by 84.8% (pre-intervention: 100%, post-intervention: 15.2%, p <.001), patient-reported experiences significantly improved (Mean responsiveness pre-intervention: 3.46, post-intervention: 3.63, p: 0.00). Initiation of insulin treatment decreased by 46.8% (pre-intervention: 25.0%, post-intervention: 13.3%, p <.001). Maternal- and neonatal clinical outcomes were not different after redesign. Weighted average costs per GDM treatment were 9.7% lower post-intervention (pre-intervention: €168,37, post-intervention: €151,97).</p><p><strong>Conclusions: </strong>The redesign of GDM care positively impacted value through decreased referrals and improved patient-reported experiences while clinical outcomes remained constant. By de-fragmenting GDM care, cost savings were realized. This study contributes to the improvement of care delivery, particularly in pregnancy and childbirth, by promoting the adoption of comprehensive, value-based evaluations of redesign initiatives and supports the further uptake of VBHC in maternity care.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"608"},"PeriodicalIF":2.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effect of counseling based on Fordyce happiness approach on happiness and childbirth satisfaction among primiparous women.","authors":"Parvin Mohebbi, Azam Maleki, Saeedeh Zenoozian, Elham Bagherinia","doi":"10.1186/s12884-025-07655-4","DOIUrl":"10.1186/s12884-025-07655-4","url":null,"abstract":"<p><strong>Background: </strong>Childbirth satisfaction is one of the important criteria of the quality of midwifery care. The study aimed to evaluate the effect of counseling based on Fordyce happiness approach on happiness and childbirth satisfaction among primiparous women.</p><p><strong>Methods: </strong>This randomized controlled clinical trial was conducted on 80 pregnant women in 2022. These mothers were experiencing their first pregnancy. They were assigned to intervention and control groups by multi-stage sampling. After three weeks (6 counseling sessions) for the intervention group, the Fordyce Happiness Questionnaire and the Mackey Childbirth Satisfaction Scale were used to collect data. Data analysis was performed using SPSS-26 software and the repeated measures analysis of variance (ANOVA) test, the independent t-test, and the chi-square test at 95% confidence level.</p><p><strong>Results: </strong>The mean happiness scores of mothers in the intervention group increased from 45.55 ± 9.76 pre-intervention to 48.2 ± 9.37 immediately post-intervention and 48.05 ± 9.06 during the follow-up period. In contrast, the control group exhibited a decrease in scores, declining from 45.6 ± 10.61 pre-intervention to 43.38 ± 9.33 post-intervention and 42.1 ± 10.43 at follow-up. Statistically significant differences in the mean scores of happiness between the two groups were observed both immediately post-intervention (p = 0.024) and at follow-up (p = 0.008). The intervention group had a mean satisfaction score of 59.58 ± 8.46, while the control group scored 48.72 ± 13.31. The total satisfaction scores differed significantly between the two groups (p = 0.001).</p><p><strong>Conclusion: </strong>Conducting counseling sessions based on Fordyce's happiness approach women was effective in improving happiness and childbirth satisfaction among primiparous women. Integrating this counseling approach into perinatal care services appears to provide mothers with emotional and psychological support.</p><p><strong>Trial registration: </strong>Ethics Committee of Zanjan University of Medical Sciences: IR.ZUMS.REC.1401.174.</p><p><strong>Registry of clinical trials: </strong>IRCT20201113049377N2.</p><p><strong>Registration date: </strong>06/09/2022 ( https://irct.behdasht.gov.ir ).</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"607"},"PeriodicalIF":2.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of pregnant women's breastfeeding myths on their breastfeeding self-efficacy: a cross-sectional study.","authors":"Aynaz Jeddi Yelsouei, Zehra Demet Üst Taşğın","doi":"10.1186/s12884-025-07738-2","DOIUrl":"10.1186/s12884-025-07738-2","url":null,"abstract":"<p><strong>Background: </strong>Myths lead to insufficient milk secretion perception and a sense of failure in mothers and are among the most common reasons for cessation of breastfeeding. Previous studies have revealed that women's beliefs in breastfeeding myths are quite common and that some traditional practices are known by all mothers and applied at low rates. The objective of the present study was to determine the effects of pregnant women's breastfeeding myths on their breastfeeding self-efficacy.</p><p><strong>Methods: </strong>This cross-sectional study was conducted on 483 nulliparous pregnant women in the gynecology and obstetrics outpatient clinics of a hospital in the east of Türkiye between March 29, 2024, and September 30, 2024. The research data were collected using the Information Form, Breastfeeding Myths Scale, and Prenatal Breastfeeding Self-Efficacy Scale. The independent samples t-test, variance, Pearson's and Spearman's correlation analysis, and single regression analysis were used to analyze the data.</p><p><strong>Results: </strong>Pregnant women scored 68.01 ± 17.72 on average on the BMS, and 98.6% had breastfeeding myths at a low level. Pregnant women scored 75.01 ± 14.89 on average on the PBSES. The analysis detected a negative and low-level correlation between the BMS and PBSES scores (p < 0.001).</p><p><strong>Conclusion: </strong>The study found that pregnant women's breastfeeding self-efficacy decreases with an increase in their breastfeeding myths. Breastfeeding myths explain 23% of the change in breastfeeding self-efficacy.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"609"},"PeriodicalIF":2.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between PAI-1 gene - 657 4G/5G polymorphism and preeclampsia in Egyptian women: a case-control study.","authors":"Omali Y El-Khawaga, Afaf M ElSaid, Hwyda Ahmed, Aliaa N El-Daw, Hend A Shalaby, Mohammed F Al-Azzawy, Manar Refaat","doi":"10.1186/s12884-025-07737-3","DOIUrl":"10.1186/s12884-025-07737-3","url":null,"abstract":"<p><p>Pre-eclampsia constitutes a pregnancy disease characterized by hypertension and proteinuria, as well as dysregulation of the coagulation cascade and hypo fibrinolysis that affects many systems. The purpose of this study is to examine the connection between (-657 4G/5G PAI-1) and the danger of preeclampsia in Egyptian females. A case-control study included 140 Egyptian pregnant women with PE along with 100 normotensive women. The study includes extracting genomic DNA from blood, detecting SNP with ARMS-PCR, and assessing metabolic parameters with serum samples. The study discovered significant variations in PAI-1 5G/4G polymorphism between sufferers and the control group in general (P < 0.001), dominant (P = 0.004), and recessive models (P = 0.009). Pre-eclamptic women had lower SOD activity and GSH levels but higher MDA and GPx activities than the normotensive pregnant group. CONCLUSION: This study indicated that the - 657 4G/5G PAI-I mutation is substantially linked to the development of PE in Egyptian women.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"610"},"PeriodicalIF":2.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and validation of a risk prediction model for hypoglycemia in patients with gestational diabetes mellitus.","authors":"Jie-Mei Yang, Li-Zhi Wang, Xiang-Feng Zhao, Qian-Cheng Ye, Cui Wan, Xiu-Zhen Li, Rui-Fen Huang, Rong-Rong Peng, Cai-Xia Liu","doi":"10.1186/s12884-025-07740-8","DOIUrl":"10.1186/s12884-025-07740-8","url":null,"abstract":"<p><strong>Objective: </strong>We explored the prevalence and determinants of hypoglycemia in patients with gestational diabetes mellitus (GDM), and we developed and validated a nomogram prediction model.</p><p><strong>Methods: </strong>We extracted data from the clinical records of 475 patients with GDM attending the tertiary class A specialized hospital in Zhuhai City between December 2021 and June 2023 for a modeling group, and we used data of another cohort of 204 GDM cases for a validation group. We conducted a logistic regression analysis to identify factors associated with hypoglycemia in patients with GDM and generated a risk prediction model presented as a nomogram. The model was validated using data from the patients in the validation group.</p><p><strong>Results: </strong>The prevalence of hypoglycemia in the study population was 25.5%. Our risk prediction model incorporated four predictors, including a fasting oral glucose tolerance test (OGTT) value, the number of fetuses, the presence or absence of intrahepatic cholestasis of pregnancy (ICP), and the blood glucose level self-monitoring frequency. The area under the receiver operating characteristic (ROC) curve was 0.786 for the modeling set and 0.742 for the validation set. The Brier score was 0.155, and the calibration slope was 0.750, demonstrating satisfactory clinical usefulness of the model. Moreover, a decision curve analysis further supported our model's clinical relevance.</p><p><strong>Conclusion: </strong>The prevalence of hypoglycemia in patients with GDM is considerable. Our nomogram prediction model demonstrated good performance for identifying high-risk individuals. The model could serve as a valuable tool for screening and managing hypoglycemia among patients with GDM.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"613"},"PeriodicalIF":2.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}