BMC Pregnancy and Childbirth最新文献

{"title":"Prenatal diagnosis of mucopolysaccharidosis type I on hepatosplenomegaly and coarse features: a case-report.","authors":"Maxime Agranier, Florence Demurger, Christele Dubourg, Jerome Fromageot, Anne-Sophie Cabaret Dufour, Erika Launay, Magalie Gournay, Charles Lefèvre, Roseline Froissart, Magali Pettazzoni, Paul Rollier","doi":"10.1186/s12884-024-07115-5","DOIUrl":"10.1186/s12884-024-07115-5","url":null,"abstract":"<p><strong>Background: </strong>Mucopolysaccharidosis type I (MPS I - IDUA gene) is a rare autosomal recessive lysosomal storage disorder. Clinical symptoms, including visceral overload, are progressive and typically begin postnatally. Descriptions of hepatosplenomegaly associated with lysosomal pathology are uncommon during the prenatal period. The most prevalent etiologies are infections, anemia, and neoplasms.</p><p><strong>Case presentation: </strong>A pregnant woman at 26.5 gestational weeks was referred to our center for fetal ultrasound findings of hepatosplenomegaly, distinct facial features, and liver, spleen and thymus echogenic spots. Whole exome sequencing after amniocentesis identified two likely pathogenic IDUA gene variants (in trans), raising suspicion of a diagnosis of MPS I. MPS I was confirmed by the deficiency of α-L-iduronidase activity in amniotic cells. A medical pregnancy termination was carried out due to the severe prognosis. After termination of pregnancy, external examination of the fetus confirmed hepatosplenomegaly and coarse dysmorphic features.</p><p><strong>Conclusion: </strong>Lysosomal storage diseases (LSD) are a rare cause of prenatal hepatosplenomegaly, but this has not been described in MPS I according to our literature search. The genetic variants identified in this case prompted early diagnosis through genome-wide studies. This rare presentation of MPS I highlights the expanding role of genomic analyses in diagnosing conditions during pregnancy.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"3"},"PeriodicalIF":2.8,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiotensin II type-1 receptor autoantibodies and effects in neonates of women with preeclampsia.","authors":"Laure Ponthier, Chahrazed El Hamel, Perrine Coste Mazeau, Sophie Martinez, Sarah Wehbe, Rachel Froget, Catherine Yardin, Vincent Guigonis","doi":"10.1186/s12884-024-07102-w","DOIUrl":"10.1186/s12884-024-07102-w","url":null,"abstract":"<p><strong>Background: </strong>Maternal agonistic autoantibodies against the angiotensin II type 1 receptor (AT1-AAs) have been implicated in the pathophysiology of preeclampsia, but their presence in their offsprings and their possible neonatal effects have not been specifically explored. This prospective study aimed to evaluate the presence of AT1-AAs and their potential clinical effects in neonates of AT1-AAs positive mothers.</p><p><strong>Methods: </strong>Women with preeclampsia and their neonates were included. Blood samples were collected in order to search for AT1-AAs.</p><p><strong>Results: </strong>AT1-AA determination was positive in 35 out of 64 of the studied women (54.7%). Thirty one newborns from the group of AT1-AA positive women were included and 22 (71%) were AT1-AA positive. The mothers' and children's AT1-AAs titers were significantly correlated. The 33 newborns from the group of AT1-AA negative women were all negative for AT1-AAs. Regarding the clinical data of newborns (birth weight, percentile of weight, gestational age, Apgar score at five minutes, mechanical or noninvasive ventilation), no significant difference was observed between the children with or without detected AT1-AAs.</p><p><strong>Conclusion: </strong>Even though AT1-AAs are detected in newborns of positive mothers during the first days of life, no specific clinical signs seem to be associated with the presence of these antibodies.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"1"},"PeriodicalIF":2.8,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying psychosocial predictors and developing a risk score for preterm birth among Kenyan pregnant women.","authors":"Anna Larsen, Jillian Pintye, Felix Abuna, Julia C Dettinger, Laurén Gomez, Mary M Marwa, Nancy Ngumbau, Ben Odhiambo, Barbra A Richardson, Salphine Watoyi, Joshua Stern, John Kinuthia, Grace John-Stewart","doi":"10.1186/s12884-024-07058-x","DOIUrl":"10.1186/s12884-024-07058-x","url":null,"abstract":"<p><strong>Background: </strong>Preterm birth (PTB) is a leading cause of neonatal mortality, particularly in sub-Saharan Africa where 40% of global neonatal deaths occur. We identified and combined demographic, clinical, and psychosocial correlates of PTB among Kenyan women to develop a risk score.</p><p><strong>Methods: </strong>We used data from a prospective study enrolling HIV-negative women from 20 antenatal clinics in Western Kenya (NCT03070600). Depressive symptoms were assessed by study nurses using the Center for Epidemiologic Studies Depression Scale (CESD-10), intimate partner violence (IPV) with the Hurt, Insult, Threaten, Scream scale (HITS), and social support using the Medical Outcomes Survey scale (MOS-SSS). Predictors of PTB (birth < 37 weeks gestation) were identified using multivariable Cox proportional hazards models, clustered by facility. We used stratified k-fold cross-validation methods for risk score derivation and validation. Area under the receiver operating characteristic curve (AUROC) was used to evaluate discrimination of the risk score and Brier score for calibration.</p><p><strong>Results: </strong>Among 4084 women, 19% had PTB (incidence rate: 70.9 PTB per 100 fetus-years (f-yrs)). Predictors of PTB included being unmarried (HR:1.29, 95% CI:1.08-1.54), lower education (years) (HR:0.97, 95% CI:0.94-0.99), IPV (HITS score ≥ 5, HR:1.28, 95% CI:0.98-1.68), higher CESD-10 score (HR:1.02, 95% CI:0.99-1.04), lower social support score (HR:0.99, 95% CI:0.97-1.01), and mild-to-severe depressive symptoms (CESD-10 score ≥ 5, HR:1.46, 95% CI:1.07-1.99). The final risk score included being unmarried, social support score, IPV, and MSD. The risk score had modest discrimination between PTB and term deliveries (AUROC:0.56, 95% CI:0.54-0.58), and Brier Score was 0.4672. Women considered \"high risk\" for PTB (optimal risk score cut-point) had 40% higher risk of PTB (83.6 cases per 100 f-yrs) than \"low risk\" women (59.6 cases per 100 f-ys; HR:1.6, 95% CI:1.2-1.7, p < 0.001).</p><p><strong>Conclusion: </strong>A fifth of pregnancies were PTB in this large multi-site cohort; PTB was associated with several social factors amenable to intervention. Combining these factors in a risk score did not predict PTB, reflecting the multifactorial nature of PTB and need to include other unmeasured factors. However, our findings suggest PTB risk could be better understood by integrating mental health and support services into routine antenatal care.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"2"},"PeriodicalIF":2.8,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and internal validation of a prognostic model for predicting tonic-clonic seizures during pregnancy in women with epilepsy.","authors":"Yanru Du, Wenting Huang, Ying Wang, Jiahe Lin, Niange Xia, Zhenguo Zhu, Xinshi Wang, Yuchen Xu, Huiqin Xu","doi":"10.1186/s12884-024-07112-8","DOIUrl":"10.1186/s12884-024-07112-8","url":null,"abstract":"<p><strong>Background: </strong>We aim to develop a model to predict the probability of tonic-clonic seizures in women with epilepsy (WWE) at any point during pregnancy until six weeks postpartum.</p><p><strong>Methods: </strong>We conducted a screening of patients diagnosed with epilepsy and who were pregnant, at a tertiary hospital in China, during the period of 1 January 2010 to 31 December 2020. We then followed up with these patients for at least one year postpartum. A total of 271 eligible patients were included in the cohort. The outcome was the occurrence of a tonic-clonic seizure during pregnancy or within six weeks postpartum. Predictors were screened through univariate analysis, and models were fitted through multivariate logistic regression analysis. Further, we compared the WMU model with the AntiEpileptic drug Monitoring in PREgnancy (EMPiRE) model in terms of discrimination (the area under receiver operating characteristic curve [AUC]), accuracy (GiViTI calibration belt), decision curve analysis (DCA), net reclassification index (NRI), and integrated discrimination improvement (IDI). Finally, we plotted a nomogram of the WMU model.</p><p><strong>Results: </strong>Of the 271 pregnant WWE, 62 patients (22.9%) had the outcome. The WMU model included three predictors: age at the time of pregnancy, admission to hospital for seizures in previous pregnancy, and seizures in the 12 months before pregnancy. Compared to the EMPiRE model, the AUC value of the WMU model was higher (0.76 vs. 0.639, P < 0.05). GiViTI calibration belt showed that the predicted risks of the WMU model were mostly consistent with the observed risks. In terms of DCA, the WMU model revealed the highest net proportional benefit for predicted probability thresholds between 10% and 90%. Additionally, our model exhibited better reclassification performance than the EMPiRE model (NRI: 0.331, P < 0.01 and IDI: 0.129, P < 0.01).</p><p><strong>Conclusion: </strong>We attempted to develop a prognostic model for predicting the risk of tonic-clonic seizures in pregnant WWE. The WMU model showed good performance, but without external validation, it is unclear whether WMU model could be generalized.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"24 1","pages":"887"},"PeriodicalIF":2.8,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11687190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for methotrexate treatment failure in tubal ectopic pregnancy: a retrospective cohort study.","authors":"Linru Fu, Xinyan Liu, Zhao Tian, Zhe Du, Xinyi Wang, Xiuqi Wang, Xiaodong Li, Tao Xu, Zhijing Sun","doi":"10.1186/s12884-024-07122-6","DOIUrl":"10.1186/s12884-024-07122-6","url":null,"abstract":"<p><strong>Background: </strong>Ectopic pregnancy (EP) accounts for approximately 2% of all pregnancies, with tubal ectopic pregnancies (TEPs) being the most common type. Methotrexate (MTX) is a noninvasive and effective medical management option for TEP, but failure rates range from 10 to 36%, posing challenges in clinical practice. Identifying risk factors for MTX treatment failure is crucial to improve patient outcomes and guide clinical decision-making. This study aimed to determine the risk factors associated with MTX failure in TEP patients and support personalized treatment strategies.</p><p><strong>Methods: </strong>This retrospective study included female patients who were diagnosed with TEP at Peking Union Medical College Hospital (PUMCH) between January 2016 and December 2022. Patients received MTX treatment initially, with dosing intervals and protocols varying according to clinical practice. MTX treatment failure was defined as the need for surgery after MTX administration. The study included two groups: patients who failed MTX treatment (n = 91) and those who succeeded in treatment (n = 268). Univariate and multivariate logistic regression analyses were performed to identify significant predictors of MTX treatment failure. A nomogram was developed to visualize the predictive factors.</p><p><strong>Results: </strong>A total of 359 patients were included, with 268 (74.7%) succeeding with MTX and 91 (25.3%) required surgery. Specifically, 282 patients (78.6%) received 1-dose MTX, whereas 77 (21.4%) received 2-dose MTX. Univariate analysis revealed that gravidity, previous EP, gestational age, pretreatment β-human chorionic gonadotropin (β-hCG) level, number of MTX treatments, and presence of a visible yolk sac in ultrasound were significant predictors (all P < 0.05). Multivariate analysis confirmed that higher gravidity (odds ratio (OR) = 1.2487, 95% confidence interval (CI): 1.0103 - 1.5433, P = 0.040) and elevated pretreatment β-hCG levels (OR = 1.0006, 95% CI: 1.0004 - 1.0008, P < 0.001) were independent risk factors. Number of MTX treatments was a significant protective factor (OR = 0.4409, 95% CI: 0.2153 - 0.9025, P = 0.025). The nomogram incorporating these six risk factors was developed.</p><p><strong>Conclusion: </strong>Higher gravidity and elevated β-hCG levels were significant predictors of MTX failure, while more MTX doses provided a protective effect. These findings underscore the importance of personalized MTX treatment strategies to improve outcomes in TEP. However, the limitations of this study, including its retrospective and single-center design, suggest that further prospective multicenter studies are needed to validate these results.</p><p><strong>Trial registration: </strong>The trial is registered at http://www.chictr.org.cn . [registration number: ChiCTR2400081314; registration date: 2024-02-28 (prospectively registered)].</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"24 1","pages":"884"},"PeriodicalIF":2.8,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11686986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vertebral level in pregnancy according to the posterior superior iliac spine: an observational study.","authors":"Ping Li, Dong Luo, Haibo Qu, Xuesheng Li, Linli Luo","doi":"10.1186/s12884-024-07113-7","DOIUrl":"10.1186/s12884-024-07113-7","url":null,"abstract":"<p><strong>Background: </strong>While the line joining the posterior superior iliac spine (PSIS) intersects a relatively stable sacral vertebra, it does not directly facilitate the localization of lumbar interspace or assist in the positioning for neuraxial anesthesia. Our study aimed to explore the potential of the PSIS line as a reference point and to determine its practical applicability in clinical settings.</p><p><strong>Methods: </strong>We consecutively enrolled pregnant women with gestational ages ranging from 24 to 38 weeks scheduled for magnetic resonance imaging (MRI) examination. Two anesthesiologists used ink to mark the PSIS line through visual localization or palpation. Subsequently, an equilateral triangle was constructed with the PSIS line as the baseline, with the vertex intersected the lumbar spine towards the head. Marker capsules were then affixed to the vertex of PSIS-line-based triangle and PSIS line, and MRI was performed with participants in the supine position. The vertebral body or interspinous space intersected by the PSIS line and vertex was recorded.</p><p><strong>Results: </strong>One hundred parturients were analyzed. The PSIS line intersected the L5 vertebral body, L5-S1 interspinous space, S1 vertebral body, S2 vertebral body, and S3 vertebral body in 11, 10, 62, 15, and 2 cases, respectively. Furthermore, the vertex of PSIS-line-based triangle intersected the L2 vertebral body, L2-3 interspinous space, L3 vertebral body, L3-4 interspinous space, and L4 vertebral body in 4, 7, 53, 20, and 16 cases, respectively. No significant correlation was detected between the vertebral levels intersected of the PSIS line and the parameters of height, weight, and gestational age.</p><p><strong>Conclusions: </strong>The PSIS line commonly intersects S1 vertebral body, and vertebral levels intersected of the PSIS-line-based vertex rang from L2 to L4 vertebral body in pregnant women. The PSIS-line-based triangle has potential to aid identification of vertebral levels, which could be applied to neuraxial anesthesia.</p><p><strong>Trial registration: </strong>The study was registered in Chinese Clinical Trials Registry(Ref. ID: ChiCTR-DDD-16010067).</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"24 1","pages":"888"},"PeriodicalIF":2.8,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11686894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of postpartum clinical guideline on maternal outcomes in iranian women: a randomized controlled clinical trial.","authors":"Leila Abdoli Najmi, Sakineh Mohammad-Alizadeh-Charandabi, Shayesteh Jahanfar, Fatemeh Abbasalizadeh, Haniyeh Salehi Poormehr, Mojgan Mirghafourvand","doi":"10.1186/s12884-024-07109-3","DOIUrl":"10.1186/s12884-024-07109-3","url":null,"abstract":"<p><strong>Background: </strong>The postpartum period is a vital time for women, infants, spouses, parents, caregivers and families. Considering the importance of postpartum care and the necessity of using comprehensive and up-to-date clinical guidelines in Iran, this study was designed to implement a indigenized clinical guideline in Iran on maternal outcomes, including maternal functioning, postpartum depression and postpartum specific anxiety (primary outcomes) as well as infant care, maternal health problems, experiencing violence, feeding method and contraception use (secondary outcomes).</p><p><strong>Methods: </strong>This randomized controlled trial was conducted with 272 postpartum women in Taleghani and Alzahra hospitals in Tabriz in 2023. Participants were randomly allocated to intervention and control groups. The intervention group received care and training based on clinical guideline while the control group received routine care and training. Both groups were followed up by telephone at the second and sixth week after delivery. Questionnaires assessing maternal health problems and postpartum depression were completed in the second and sixth weeks and while assessments of maternal functioning, postpartum depression, postpartum specific anxiety, infant care behavior, and experiences of violence were conducted in the sixth week after delivery. ANCOVA, independent-t tests, and Mann-Whitney U tests were used for data analysis.</p><p><strong>Results: </strong>There was no significant difference between the two groups regarding of socio-demographic characteristics (P < 0.05). Additionally, there were no significant differences in the mean score of maternal functioning, anxiety, depression, infant care behavior or experiences of violence after the intervention between the intervention and control groups based on ANCOVA or Mann-Whitney U tests (P < 0.05). However, the rate of infant formula use was significantly lower in the intervention group (12.9%) compared to the control group (23.4%) (P = 0.027). In terms of contraceptive methods used, 24.3% of the intervention group and 22.2% of the control group reported using reliable contraceptive methods )P = 0.035(. Furthermore, 98.5% of participants in the intervention group expressed satisfaction with the education and recommendations provided, compared to 88.2% in the control group (P = 0.002).</p><p><strong>Conclusion: </strong>Providing clinical guideline-based care was associated with increased breastfeeding rates, greater use of reliable contraception methods, and higher levels of maternal satisfaction. However, it did not have a significant impact on other maternal outcomes.</p><p><strong>Trial registration: </strong>Iranian Registry of Clinical Trials (IRCT) IRCT20120718010324N76 Date of registration 27/1/2023. URL: https://trialsearch.who.int/Trial2.aspx?</p><p><strong>Trialid: </strong>IRCT20120718010324N76 DATE OF FIRST REGISTRATION: 27/3/2023.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"24 1","pages":"886"},"PeriodicalIF":2.8,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11687045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment and counselling preferences of postpartum women with and without symptoms of (childbirth-related) PTSD: findings of the cross-sectional study INVITE.","authors":"Rosa Hannele Horstmann, Lara Seefeld, Julia Schellong, Susan Garthus-Niegel","doi":"10.1186/s12884-024-07061-2","DOIUrl":"10.1186/s12884-024-07061-2","url":null,"abstract":"<p><strong>Background: </strong>Post-traumatic stress disorder (PTSD) in the postpartum period is a prevalent yet under-researched mental health condition. To date, many women who suffer from postpartum PTSD remain unrecognized and untreated. To enhance the accessibility of help for these women, it is crucial to offer tailored treatment and counselling services that align with their needs. This study aimed to understand how support preferences differ between women with and without postpartum PTSD, considering the two subgroups of postpartum PTSD: childbirth-related PTSD (CB-PTSD) and general PTSD (gPTSD).</p><p><strong>Methods: </strong>This study used data from the cross-sectional INVITE study, comprising telephone interviews with N = 3,874 women conducted six weeks to six months after childbirth. The City Birth Trauma Scale (City BiTS) was used to assess CB-PTSD, while the Primary Care Posttraumatic Stress Disorder Screen for DSM-5 (PC-PTSD-5) was used to assess gPTSD. Service preferences and preferred modes of service provision were measured with self-developed questionnaires. Analyses of variance were used to identify differences between groups.</p><p><strong>Results: </strong>The support services (family-)midwives and family, friends, or colleagues and the service provision mode as in person communication were preferred most by women across groups. The analyses revealed that women with CB-PTSD had lower overall preferences for services compared to women without postpartum PTSD. Women with CB-PTSD also showed less preference for psychotherapeutic services (e.g. outpatient treatment, inpatient clinics) compared to women without postpartum PTSD. Regarding modes of service provision, women with gPTSD had a higher preference for all service modes compared to women with CB-PTSD and those without postpartum PTSD, with a stronger preference for both direct (e.g. in person, video conference) and delayed communication (e.g. chat, e-mail).</p><p><strong>Conclusion: </strong>This study was the first to explore the support preferences of women experiencing symptoms of postpartum PTSD. Findings suggest that women differ in their preferences, contingent upon the subgroup of postpartum PTSD. According to women's overall preferences, the expansion and further training of (family-)midwife services is recommended. By tailoring support services accordingly to women's preferences, it may be possible to bridge the treatment gap for postpartum PTSD and to improve the well-being of affected women and their families.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"24 1","pages":"885"},"PeriodicalIF":2.8,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11686938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the implementation value of abdominal B-ultrasound combined with cervical cerclage in the prevention and treatment of late recurrent spontaneous abortion.","authors":"Lili Shi, Lei Dong, Yuanying Cui, Dan Bu, Bo Hu","doi":"10.1186/s12884-024-06912-2","DOIUrl":"10.1186/s12884-024-06912-2","url":null,"abstract":"<p><strong>Objective: </strong>To study the implementation value of abdominal B-ultrasound combined with cervical cerclage in the prevention and treatment of recurrent late abortion.</p><p><strong>Methods: </strong>From October 2020 to December 2023, 196 pregnant patients who had a history of late abortions at our institution were chosen. They were divided into groups based on the treatments used. In the observational team, 98 instances received abdominal B-ultrasound along with cervical cerclage, while 98 instances in the controlling team underwent traditional conservative treatment. Vaginal flora, inflammatory factor levels, labor outcomes, uterine artery parameters, and adverse effects were observed in both groups of pregnant women.</p><p><strong>Results: </strong>Comparing the detection of vaginal flora between the two groups, the difference was not statistically significant (P > 0.05); the detection values of WBC, neutrophil percentage and neutrophil absolute value in the observation group were lower than those in the control group (P < 0.05). The recurrent late abortion rate (4.08%) and premature delivery rate (16.33%) were lower than those of the control group, and the full-term delivery rate (79.59%) and total fetal survival rate (93.88%) were higher than those of the control group, and the difference was statistically significant (P < 0.05). The resistance index (RI) and pulsatility index (PI) of pregnant women with abortion were higher than those of live birth pregnant women. The RI and PI of group A (pregnant women with recurrent late abortion) at 7, 12, 24 and 32 weeks of gestation were also higher than those of group B (pregnant women without recurrent late abortion), and the difference was statistically significant (P < 0.05). At 7 weeks of gestation, there was no statistical difference between the observation and control groups in terms of RI and PI (P > 0.05)0.12 By 32 weeks of gestation, the RI and PI were lower in the observation group than in the control group (P < 0.05)0.13 In the observation group, the RI and PI were lower than in the control group (P < 0.05). The incidence of gestational hypertension, gestational diabetes mellitus, and eclampsia were significantly lower in the observation group compared to the control group (P < 0.05).</p><p><strong>Conclusion: </strong>Abdominal ultrasound combined with cervical cerclage reduces the risk of miscarriage by improving the hemodynamic status of the uterus and placenta, and also optimizes the pregnancy environment by reducing the inflammatory response in the uterine cavity, which has important clinical applications in the prevention and treatment of late recurrent spontaneous abortion.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"24 1","pages":"889"},"PeriodicalIF":2.8,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11687003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Newborn morbidities and care procedures at the special newborn care units of Gandaki Province, Nepal: a retrospective study.","authors":"Khim Bahadur Khadka, Nabina Koirala, Olena Ivanova, Ramchandra Bastola, Dela Singh, Kamala Rana Magar, Bidhya Banstola, Ramesh Prasad Adhikari, Vincentas Giedraitis, Deepak Paudel, Guenter Froeschl","doi":"10.1186/s12884-024-07120-8","DOIUrl":"10.1186/s12884-024-07120-8","url":null,"abstract":"<p><strong>Background: </strong>Despite recent improvements in the overall health status of Nepal's population, newborn morbidities and mortalities have remained a challenge. This study explores the situation and care strategies for newborn health problems in the Gandaki Province of Nepal.</p><p><strong>Methods: </strong>This is a retrospective hospital records analysis. A structured questionnaire was employed to collect data on socio-demographic, clinical, and outcome variables in 1,355 newborns admitted to the Special Newborn Care Unit (SNCU) between May 1, 2021, and April 30, 2022, in five hospitals within the Gandaki Province.</p><p><strong>Results: </strong>Among all newborns, 60% were male, and 40% belonged to Janajati indigenous families. The mean age of mothers at the time of delivery was 24.4 years; the average birth weight of babies was 2.8 kg; and the gestational week was 38 weeks. Around 96% of births occurred in healthcare facilities. The average inpatient hospital stay was 4.7 days. The reasons for SNCU admission were newborn sepsis (51%), neonatal hyperbilirubinemia (23%), respiratory distress syndrome (18%), and low birth weight (11%). Approximately 7% of the newborns were found to have died due to various causes, including sepsis, asphyxia, and indirect medical reasons. Female newborns had a 0.45-times (CI: 0.23-0.84) lower risk of mortality compared to male newborns. Underweight newborns had 8.8 times (CI: 4.5-17.2) higher risk of death than newborns with a normal birth weight, even after adjusting for other factors like sex, delivery site, mode of delivery, mother's age, respiratory distress syndrome, neonatal hyperbilirubinemia, neonatal sepsis, and age at admission to SNCU. The most common treatments included injectable antibiotics (73%), intravenous fluids (53%), oxygen delivery (39%), and phototherapy (36%), while 3% received \"Kangaroo Mother Care (KMC)\".</p><p><strong>Conclusions: </strong>The study showed that newborns suffered from multiple health complications such as sepsis, hyperbilirubinemia, or asphyxia, and many newborns received essential medical services from hospitals. Birth weight, sex of the newborn, and respiratory distress syndrome were significantly associated with neonatal mortality. Hospitals should focus on reinforcing KMC, neonatal resuscitation, and early infection control measures.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"24 1","pages":"883"},"PeriodicalIF":2.8,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11686976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}