BMC Pregnancy and Childbirth最新文献

{"title":"Effect of nutrition education integrating the health belief model and theory of planned behavior during pregnancy on gestational weight gain and birth weight in Southeast Ethiopia using complex analyses.","authors":"Girma Beressa, Susan J Whiting, Tefera Belachew","doi":"10.1186/s12884-025-07284-x","DOIUrl":"10.1186/s12884-025-07284-x","url":null,"abstract":"<p><strong>Background: </strong>The incidence of inadequate or excessive gestational weight gain (GWG) is an indicator of reproductive health problems. However, scientific evidence for the effect of nutrition education during pregnancy on GWG and neonatal birth weight (BW) in urban settings in Ethiopia is sparse. This study aimed to assess the effect of nutrition education during pregnancy on GWG and neonatal birth weight (BW) in urban settings in Southeast Ethiopia.</p><p><strong>Methods: </strong>A community-based two-arm parallel cluster randomized controlled trial was conducted among 447 randomly selected pregnant women attending antenatal care (224 intervention and 223 control) from February to December 2021. Study participants were selected by multistage cluster sampling followed by systematic sampling. Women receiving the intervention received six nutrition education sessions, while women in the control group received standard care. GWG was the difference between the last recorded weight before delivery and the weight recorded during the first trimester. BW was measured within the first hour of delivery. The generalized structural equations model (GSEM) and structural equations model (SEM) were used to examine the direct, indirect, and total effects of nutrition education on GWG and BW via the dietary diversity score (DDS), food security (FS), and knowledge.</p><p><strong>Results: </strong>The GSEM revealed that receiving intervention during pregnancy had a total effect on GWG [(AOR = 2.056, 95% CI: 1.705, 2.695)]. Having dietary diversity had direct and total effects on GWG [(AOR = 1.105, 95% CI: 1.022, 1.196)]. Having food security had a total effect on GWG [(AOR = 1.928, 95% CI: 1.817, 2.052)]. Having fruit and vegetable knowledge had a total effect on GWG [(AOR = 1.971, 95% CI: 1.856, 2.105)]. The SEM revealed that receiving intervention during pregnancy had a direct effect on BW (unstandardized β = 0.144, 95% CI: 0.034, 0.252). Similarly, it revealed that receiving intervention during pregnancy had a direct effect on DDS (β = 0.580, 95% CI: 0.024, 1.038). Likewise, it indicated that receiving intervention during pregnancy had a total effect on increasing BW (β = 0.137, 95% CI: 0.029, 0.243). Nevertheless, there was no statistically observed indirect effect of nutrition education during pregnancy on GWG and BW via mediators.</p><p><strong>Conclusion: </strong>The SEM revealed that receiving nutrition education interventions during pregnancy had a total effect on GWG and direct and total effects on BW. The generalized structural equation modelling (GSEM) and structural equation modelling (SEM) findings show that integrating theory-based nutrition education during pregnancy will improve gestational weight gain (GWG) and birth weight (BW) in Ethiopia.</p><p><strong>Trial registration: </strong>The trial was registered on Pan African Clinical Trials Registry (PACTR202201731802989, retrospectively registered on 24/01/ 2022).</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"196"},"PeriodicalIF":2.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The assessing of clinical relevance of chromosomal microarray analysis in the prenatal diagnosis of fetal growth restriction.","authors":"Peng Li, Wenli Wu, Xiaoyun Zhang, Yuting Li, Miao Liu, Yanping Wang, Dongmei Man, Fengge Wang","doi":"10.1186/s12884-025-07305-9","DOIUrl":"10.1186/s12884-025-07305-9","url":null,"abstract":"<p><strong>Objective: </strong>Chromosomal variations are known to play a role in the etiology of fetal growth restriction (FGR). Here, we intend to investigate the significance of Chromosomal Microarray Analysis (CMA) in the prenatal diagnosis of definite FGR.</p><p><strong>Method: </strong>182 pregnant women with FGR participated in our study, undergoing CMA to identify chromosomal abnormalities. The cohort was categorized into isolated FGR, FGR with ultrasound soft marker abnormalities, and FGR associated with structural malformations.</p><p><strong>Results: </strong>The detection rates of PCNVs in FGR with structural anomalies are significantly higher than those in the isolated FGR group and the FGR group with abnormal ultrasound soft markers (19.0% vs. 2.1%, 19% vs. 1.5%; χ²=9.33, p = 0.005). Compared to FGR with a single system malformation, the diagnostic rate of chromosomal variations in FGR with multiple system malformations is markedly increased (60% vs. 6.3%; p = 0.028). Advanced maternal age, early-onset FGR, and severe FGR do not appear to influence the diagnostic rate of chromosomal variations (p > 0.05).</p><p><strong>Conclusion: </strong>Chromosomal variations pose a significant risk in FGR with structural abnormalities, associated with the number of organ systems involved. Notably, advanced maternal age, early-onset FGR, and severe FGR do not affect the diagnostic rate of chromosomal variations in FGR.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"198"},"PeriodicalIF":2.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetically predicted circulating immune cells and cytokines reveal the causal role of immune factors on female infertility: a two-sample mendelian randomization study.","authors":"Kai-Xuan Dong, Jia-Hang Mo, Jing Yan, Yi Cheng, Hui-Xi Chen, Nai-Xin Xu, Zhi-Yuan Dou, Hong Zhu, Lan Zhu, He-Feng Huang","doi":"10.1186/s12884-025-07318-4","DOIUrl":"10.1186/s12884-025-07318-4","url":null,"abstract":"<p><strong>Objectives: </strong>Previous studies suggested that immune factors may play critical roles in female infertility, but their causal links remain unclear. To address this gap, this study employs the Mendelian randomization (MR) to delineate the causal association between circulating immune factors and female infertility.</p><p><strong>Methods: </strong>This study employed summary-level data from three genome-wide association studies (GWAS) encompassing 731 peripheral immune cell signatures, 41 circulating cytokines, and five female infertility phenotypes to reveal the causal relationship between immune factors and female infertility. Causalities of exposure-outcome pairs were explored mainly using two-sample MR, and comprehensive sensitivity analyses were deployed to validate the reliability of the results. Multi-variable Mendelian randomization (MVMR) was further employed to examine the potential mediating effects between significant exposures.</p><p><strong>Results: </strong>Following false discovery rate (FDR) correction and sensitivity analyses, univariable Mendelian randomization identified distinct causal immune signatures across infertility subtypes. Peripheral levels of Naive CD8br %CD8br, MIP1B and IL17 were causally associated with general female infertility, and higher circulating MIP1B level decreased the risk of ovarian infertility. Furthermore, peripheral levels of CD80 on monocyte and MIP1B were causally associated with a higher risk of tubal infertility, three peripheral immune cell features (CD86 + myeloid DC AC, HLA DR + NK %NK, CD16 on CD14- CD16 + monocyte) were causal for uterine factor infertility, and three cytokines (MIP1B, IL18, IL17) were genetic causes of cervical infertility, vaginal infertility, other or unspecified origin infertility (FIOTHNAS). MVMR further revealed that MIP1B's effects on general female infertility and FIOTHNAS were substantially attenuated upon adjusting for circulating levels of IL17 and IL18.</p><p><strong>Conclusion: </strong>Our results highlight that immune response contributes to female infertility risk through subtype-specific mechanisms, providing clues for following clinical research and treatment.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"195"},"PeriodicalIF":2.8,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaginal bleeding during pregnancy and adverse pregnancy outcomes: a nationwide population-based retrospective cohort study in Iran.","authors":"Mina Tahmasebifard, Sima Afrashte, Mahmoud Hajipour, Behnam Zamani, Shahab Rezaeian","doi":"10.1186/s12884-025-07324-6","DOIUrl":"10.1186/s12884-025-07324-6","url":null,"abstract":"<p><strong>Background: </strong>Vaginal bleeding (VB) as a common pregnancy problem affects approximately one fourth of pregnancies and leads to abortion in 50% of cases. The occurrence of vaginal bleeding during pregnancy heightens the probability of experiencing diverse adverse pregnancy outcomes. The existing scientific research regarding the relationship between vaginal bleeding and adverse pregnancy outcomes in Iranian women is restricted and presents conflicting findings. Consequently, this research examines the association of vaginal bleeding during pregnancy and unfavorable outcomes in Iranian women.</p><p><strong>Methods: </strong>This population based retrospective cohort study was conducted in 11 provinces of Iran. The necessary data were collected using the questionnaires and medical records from 3634 pregnant women. The association between vaginal bleeding and stillbirth, premature birth, low birth weight, premature membrane rupture of the membranes (PPROM), gestational diabetes, and pre-eclampsia was done using univariable and multivariable logistic regression.</p><p><strong>Results: </strong>The prevalence of vaginal bleeding has a declining trend based on BMI and birth cohort of women. Multivariable logistic regression showed that the odds of low birth weight (OR = 1.52, 95%CI: 1.04-2.24), PPROM (OR = 2.12, 95%CI: 1.19-3.76), preterm birth (OR = 1.74, 95%CI: 1.19-2.56), and stillbirth (OR = 2.10, 95%CI: 1.59-2.77) are significantly higher in women who experience vaginal bleeding during pregnancy in compared to women who do not have vaginal bleeding.</p><p><strong>Conclusions: </strong>Although a declining trend of vaginal bleeding was found, these findings indicate an increased risk of stillbirth, preterm birth, and low birth weight due to VB. Educational interventions to prevent adverse pregnancy outcomes among high-risk women are suggested.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"193"},"PeriodicalIF":2.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiencing weight stigma during childbirth increases the odds of cesarean birth.","authors":"Regula A Schwenk, Carmen Wyss, Evelyne M Aubry","doi":"10.1186/s12884-025-07251-6","DOIUrl":"10.1186/s12884-025-07251-6","url":null,"abstract":"<p><strong>Background: </strong>Weight-biased clinical practices and institutional characteristics can have a wide impact on the quality of care provided to women with obesity. This may substantially increase their risks for poor birth outcomes. The current study assessed experienced weight stigma by women during childbirth in maternity care settings in Switzerland. We aimed to identify frequencies, sources, and manifestations of weight-related stigmatization, hypothesizing that such stigma impacts birth outcomes, specifically cesarean birth (CB).</p><p><strong>Methods: </strong>Data from a nationwide cross-sectional online survey was used to investigate the frequencies, sources, and manifestations of experienced weight stigma during childbirth. Binomial logistic regression was applied to predict CB from experienced weight stigma. Mediation analysis assessed the role of experienced weight stigma in the association between body mass index (BMI) and CB.</p><p><strong>Results: </strong>In a total of 1352 women who gave birth in the last five years, women with obesity (BMI ≥ 30 kg/m2) experienced weight stigma more often than their peers with healthy weight (BMI 18.5-24.9 kg/m2). Obstetricians were identified as a major source of weight stigma, accounting for 77.8% of stigmatization experienced by women, compared to stigmatization perceived from nurses (21.7%) and midwives (23.8%). Overall, weight stigma was mostly experienced in the form of dismissive or critical comments towards a woman's figure or weight. Significantly more women with obesity indicated being blamed for weight-related risks during childbirth than their healthy-weighted peers (χ²(2) = 22.2, P < 0.001). An increase in the frequency of experienced weight stigma was related to higher odds of intrapartum CB ([aOR], 1.08; 95% CI, 1.02,1.15; P < 0.05), and it partially mediated the relationship between increased pre-pregnancy BMI and CB (b = 0.07, SE = 0.029; P < 0.05).</p><p><strong>Conclusion: </strong>Women with obesity reported the highest proportion of weight stigmatization during childbirth, experiencing stigma more frequently than women without obesity. This increased frequency of weight stigma was associated with higher odds of CB. Raising awareness among healthcare providers and reducing potential biases and stigmatization may improve care quality and health outcomes for women with obesity.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"191"},"PeriodicalIF":2.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferroptosis-related genes in preeclampsia: integrative bioinformatics analysis, experimental validation and drug prediction.","authors":"Lidan He, Feng Zhan, Xuemei Li, Huijuan Yang, Jianbo Wu","doi":"10.1186/s12884-025-07325-5","DOIUrl":"10.1186/s12884-025-07325-5","url":null,"abstract":"<p><strong>Introduction: </strong>Preeclampsia (PE) is a severe pregnancy complication with limited early diagnostic and therapeutic options. Ferroptosis, an iron-dependent cell death pathway, has emerged as a potential mechanism in PE pathogenesis. This study investigated ferroptosis-related genes (FRGs) in PE to identify diagnostic biomarkers and therapeutic targets.</p><p><strong>Methods: </strong>Differentially expressed genes were identified from GEO databases and intersected with FRGs. Hub genes were selected using RandomForest and LASSO algorithms. Their diagnostic potential was evaluated through ROC analysis. Regulatory networks were constructed using transcription factors, microRNAs and potential drug targets. Hub gene expression was validated through immunohistochemistry, Western blot, and RT-qPCR in placental tissues and hypoxic trophoblasts.</p><p><strong>Results: </strong>We identified 25 ferroptosis-related differentially expressed genes enriched in ferroptosis and HIF-1 pathways. Four hub genes (NDRG1, P4HA1, LDHA, and IDO1) showed high diagnostic efficiency (AUC=0.9182). Immune cell analysis revealed altered levels of plasma cells, CD8+ T cells, Tregs, monocytes, and M2 macrophages in PE, correlating significantly with hub gene expression. We identified 84 mRNA-miRNA and 119 mRNA-TF interactions. Among 19 potential drugs, Tetrahydro-NAD showed promising targeting potential. Experimental validation confirmed elevated expression of NDRG1, P4HA1, and LDHA, and decreased IDO1 in PE tissues and hypoxic conditions.</p><p><strong>Discussion: </strong>This study identified four FRGs as potential PE biomarkers and therapeutic targets, providing new insights into PE pathogenesis through integrated bioinformatics and experimental validation. These findings may facilitate early PE diagnosis and treatment development.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"189"},"PeriodicalIF":2.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"I'm not alone\": perinatal women's experiences in an online self-directed program for perinatal anxiety.","authors":"Light Uchechukwu, Madison P Hardman, Isabelle Hadley, Megan E Gornik, Sarah K Petty, Teaghan A M Pryor, Gillian M Alcolado, Patricia Furer, Kristin A Reynolds","doi":"10.1186/s12884-025-07270-3","DOIUrl":"10.1186/s12884-025-07270-3","url":null,"abstract":"<p><strong>Background: </strong>Anxiety is highly prevalent during pregnancy and postpartum, and access to treatment can be difficult due to a range of barriers (e.g., time, distance, and service availability). Online treatments have the potential to circumvent these barriers and may, therefore, be beneficial for the perinatal population. The present study leveraged qualitative methods to understand participants' perspectives on their use of a six-module online self-directed Cognitive Behavioral Therapy (CBT) program for perinatal anxiety as part of a randomized controlled trial.</p><p><strong>Methods: </strong>A mixed qualitative method design was used for this study. A total of 95 perinatal women were randomized to an intervention or waitlist control condition for an online self-directed program (Overcoming Perinatal Anxiety; OPA). Both waitlist and intervention participants provided open-ended feedback on each module via online surveys. A subset of individuals (n = 20) assigned to the intervention condition completed a virtual qualitative interview about their experiences using the program. Data obtained from open-ended survey questions and qualitative interviews were analyzed using Conventional Content Analysis (open-ended survey) and Reflexive Thematic Analysis (interviews).</p><p><strong>Results: </strong>Open-ended survey data were categorized into three themes, with associated sub-themes: User experience (subthemes: accessibility and modality), Perceptions of content (sub-themes: validating, informative, hopeful, anxiety-inducing, emotionally \"heavy\", and helpful), and Barriers to program engagement (subthemes: lack of time and energy, technical difficulties, challenging and external factors). Qualitative interview data were categorized into the following main themes, with associated subthemes: Tensions in engaging with the self-directed program (subthemes: connecting and multi-tasking, \"finding the time,\" module length and pacing, pen to paper, and \"thanks for the reminder but don't rush me\"), \"I'm not alone,\" (subthemes: relating to the content, sharing anxiety with \"inner circle,\" and voicing a desire to connect with other \"moms feeling the same way\"), and \"I'm managing my anxiety\" (subthemes: \"understanding my anxiety,\" using \"strategies to help with my anxiety,\" \"taking time for myself,\" and moving forward).</p><p><strong>Conclusion: </strong>Findings highlight that online self-directed treatment can be an acceptable and feasible option for perinatal anxiety. Findings show promise for the scalability of OPA to improve access to psychological treatment for perinatal people experiencing anxiety.</p><p><strong>Trial registration: </strong>Clinical Trial Identifier: NCT04844138 (clinicaltrials.gov). Trial registration submitted: [April 5, 2021] accepted: [April 14, 2021].</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"190"},"PeriodicalIF":2.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between fear of childbirth and prenatal depression in pregnant women during pregnancy: a cross-lagged analysis.","authors":"Qian Jing, Jiang Jie, Xu Ke, Yang Liu, Deng Xiumin, Li Xiuchuan, Li Jinzhi","doi":"10.1186/s12884-025-07321-9","DOIUrl":"10.1186/s12884-025-07321-9","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the reciprocal predictive relationship or quasi-causal relationship between fear of childbirth and antenatal depression in pregnant women via cross-lagged modeling.</p><p><strong>Methods: </strong>Pregnant women who attended prenatal examinations at a Grade 3 A hospital in Bengbu City, Anhui Province, from November 2022 to March 2023 were randomly selected as the study subjects. A total of 219 pregnant women were followed up longitudinally three times during pregnancy using the General Information Questionnaire, the Wijma Expectation/Experience of Childbirth Questionnaire, and the Edinburgh Postnatal Depression Inventory, and were then statistically analyzed using a cross-lagged model.</p><p><strong>Results: </strong>The results revealed a positive correlation between maternal fear of childbirth and prenatal depression score on all three measures (r = 0.426, 0.519, 0.420, P < 0.001). Repeated measures ANOVA showed that maternal fear of childbirth tended to gradually increase during pregnancy, while prenatal depression first decreased and then stabilized. The results of the cross-lagged model showed that the T1 and T2 fear of childbirth scores significantly predicted the T2 and T3 prenatal depression scores (β = 0.184, 0.112, P < 0.05). The T1 fear of childbirth score significantly predicted the T2 fear of childbirth score (β = 0.127, P < 0.05), but the T2 fear of childbirth score was not significantly predictive of the T3 fear of childbirth score (β = 0.060, P > 0.05).</p><p><strong>Conclusion: </strong>Fear of childbirth and antenatal depression interact with each other during pregnancy, and this relationship develops dynamically, with fear of childbirth having a more stable and lasting predictive effect on antenatal depression. Maternal mental health status can be assessed early in pregnancy via our pregnancy health care services to guide targeted interventions throughout the perinatal period.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"192"},"PeriodicalIF":2.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment and validation of a nomogram for predicting preterm birth in intrahepatic cholestasis during pregnancy: a retrospective study.","authors":"Wenchi Xie, Landie Ji, Dan Luo, Lili Ye, Qian Li, Landan Kang, Qingquan He, Jie Mei","doi":"10.1186/s12884-025-07320-w","DOIUrl":"10.1186/s12884-025-07320-w","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to develop and evaluate a nomogram for predicting preterm birth in patients with intrahepatic cholestasis of pregnancy (ICP), with a view to assisting clinical management and intervention.</p><p><strong>Methods: </strong>This retrospective observational study included 257 pregnant women with ICP from Sichuan Provincial People's Hospital between January 1, 2022 and July 30, 2024. The routine clinical and laboratory information of these patients were also collected. We used the least absolute shrinkage and selection operator (LASSO) and multivariable logistic regression analysis to investigate the association between clinical and laboratory data and preterm birth in ICP patients. A nomogram was developed to predict the likelihood of preterm birth in ICP patients. The prediction accuracy of the model was evaluated by consistency index (C-index), receiver operating characteristic (ROC) curve, area under the curve (AUC), and calibration curve. Decision curve analysis (DCA) was used to evaluate its applicability in clinical practice.</p><p><strong>Results: </strong>Among the 257 ICP patients, 56 (21.79%) were diagnosed with preterm birth. Cases were randomly divided into a training set (154 cases) and a test set (103 cases). A nomogram was developed to predict preterm birth in ICP patients based on height, twin pregnancy (TP), gestational age at diagnosis (GA at diagnosis), and total bile acid level (TBA) at diagnosis. The calibration curve of the training set was close to the diagonal (C-index = 0.864), and the calibration curve of the test set was also close to the diagonal (C-index = 0.835). These results indicate that the model has a good consistency. The AUC of the training group and the test group were 0.864 and 0.836, respectively, indicating the good accuracy of the model. The DCA reveals that this nomogram could be applied to clinical practice.</p><p><strong>Conclusion: </strong>The combination of TBA level, TP, height and GA at diagnosis is an effective model for identifying preterm birth in ICP patients. These results will help guide the clinical management and treatment of patients with ICP, thereby reducing maternal and infant safety issues caused by preterm birth.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"194"},"PeriodicalIF":2.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-pneumatic anti-shock garment utilization and associated factors in Ethiopia: a systematic review and meta-analysis.","authors":"Gedion Asnake Azeze, Gizachew Ambaw Kassie, Afework Alemu Lombebo, Amelework Gonfa Efa, Yordanos Sisay Asgedom, Berhan Tsegaye Negash, Beshada Zerfu Woldegeorgis, Kirubel Eshetu Haile, Bulcha Guye Adema, Amanuel Yosef Gebrekidan","doi":"10.1186/s12884-025-07299-4","DOIUrl":"10.1186/s12884-025-07299-4","url":null,"abstract":"<p><strong>Background: </strong>The Non-pneumatic Anti-Shock Garment (NASG) serve as a crucial first-aid device designed to apply pressure to the lower body. This device can save women's lives through reducing blood loss and stabilizing the women until definitive treatment is available. Between 2013 and 2015, health institutions in Ethiopia that implemented the NASG reported reduction of 80% in maternal deaths from haemorrhagic shock.So far, a number of studies have been carried out across various regions of Ethiopia to evaluate the extent of Non-pneumatic Anti-Shock Garment. However, the findings have yielded inconsistent conclusions, particularly in developing countries such as Ethiopia. The aim of this study is, therefore, to assess the pooled prevalence of non-pneumatic anti-shock garment utilization and associated factors in Ethiopia.</p><p><strong>Methods: </strong>The Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) checklist was employed in this study. Relevant articles, written in English, were searched in electronic databases like Medline, Embase, Hinari, AJOL, the Web of Science, Google Scholar and SienceDirect. All observational studies completed or published up to May 31, 2023 and reporting on magnitude of non-pneumatic anti-shock garment utilization and its associated factors were included. The first author name, year of publication, region, town, study design, population, sample size, response rate, total cases and prevalence were all extracted using data extraction format. Data were analyzed using STATA V.15 statistical software. We estimated the pooled odds ratio (OR) along with 95% confidence interval (95% CI).</p><p><strong>Results: </strong>In this review, we included eight published papers comprising 2690 study participants. The estimated pooled utilization of non-pneumatic anti-shock garment was 43.2% (95% CI: 35.88, 50.52; I² = 93.5%; P-value < 0.001). In particular, the availability of the NASG at an institution, receiving training on the NASG and having good knowledge regarding NASG utilization were significantly associated with increased odds for NASG utilization.</p><p><strong>Conclusion: </strong>The reported estimates of the level of NASG utilization in Ethiopia have remained poor. The availability of the NASG at an institution, receiving training on the NASG, and having good knowledge regarding NASG utilization were significantly associated with NASG utilization in Ethiopia. Therefore, the current study reinforces the need to implement and to scale up the use of the NASG to prevent excessive blood loss after childbirth.</p><p><strong>Review registration: </strong>Registered in PROSPERO database on April 08, 2023 with registration number of CRD42023412128.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"187"},"PeriodicalIF":2.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}